The Syllabus of the Discipline Clinical Pharmacology Has Been Developed

The syllabus of the discipline clinical pharmacology has been developed in accordance with the Federal state educational standard of higher education (FSES HE) for the specialty 31.05.01 General medicine with the account of the guidelines of the sample basic educational program of higher education of the specialty 31.05.01 General medicine

1. Objective and goals of the discipline The objective of teaching the discipline. The main objective of teaching clinical pharmacology is to teach the future doctor: 1. individualization of the pharmacotherapy choice on the basis of knowledge of pharmacodynamics, pharmacokinetics, interactions and side effects of drugs, on the one hand, and features of the disease, changes in drugs metabolism in the patient's body, on the other hand; 2. methods for monitoring the efficacy and safety of drugs. Аttention is paid to the ethical aspects of the doctor-patient relationship in pharmacotherapy, the culture of the doctor’s behavior in the treatment process, and the legal and ethical issues of new drugs testing.

Goals of teaching the discipline. The main goals are the formation of knowledge, skills and abilities of pharmacological support for the treatment of diseases, based on the study of the following sections of clinical pharmacology: 1. Pharmacokinetics of main groups of drugs. 2. Pharmacodynamics of main groups of drugs. 3. Features of local and systemic use of drugs. 4. Features of pharmacotherapy in renal dysfunction. 5. Features of pharmacotherapy in liver dysfunction. 6. Basics of combined pharmacotherapy. 7. Side effects of drugs and their prevention. 8. Algorithms of pharmacotherapeutic strategies for the correction of diseases.

2. Position of the discipline in the structure of the educational program and re- quirements to the planned outcomes of teaching the discipline

The discipline clinical pharmacology is referred to the basic part of the educational program.

The process of studying the discipline provides gaining the planned outcomes of mastering the educational program and is aimed at forming the following competencies:

Competency Logical connection with disciplines on Code Definition the curriculum GPC-4 Able and ready to implement Nursing; bioethics; propedeutics of internal ethical and deontological diseases; general surgery; dermatovenere- principles in professional ac- ology; neurology; faculty therapy; faculty tivities surgery; urology; obstetrics and gynecology; otorhinolaryngology; ophthalmology; endocrinology; phthisiology; psychiatry, medical psychology; hospital therapy. occupational disease; polyclinic therapy, physiotherapy; traumatology, orthopedics; hospital surgery; neurosurgery; infectious diseases; anesthesiology, resuscitation, intensive care; dentistry; oncology, radiation therapy; pediatric surgery; childhood infectious diseases; clinical immunology; surgical diseases; tropical diseases; obstetric and gynecological care. GPC-5 Is able and ready to analyze Propedeutics of internal diseases; general the results of one’s own ac- surgery; dermatovenereology; neurology; tivity to avoid professional faculty therapy; faculty surgery; urology; mistakes obstetrics and gynecology; otorhinolaryngology; ophthalmology; endocrinology; phthisiology; psychiatry, medical psychology; hospital therapy. occupational disease; polyclinic therapy, physiotherapy; traumatology, orthopedics; hospital surgery; neurosurgery; infectious diseases; anesthesiology, resuscitation, intensive care; forensic Medicine; oncology, radiation therapy; clinical pathology; pediatric surgery; childhood infectious diseases; clinical immunology; surgical diseases; tropical diseases; obstetric and gynecological care.

GPC-6 Is ready to maintain medical Nursing; propedeutics of internal diseases; documentation general surgery; public health and healthcare; dermatovenereology; neurology; faculty therapy; faculty surgery; urology; obstetrics and gynecology; otorhinolaryngology; ophthalmology; endocrinology; phthisiology; psychiatry, medical psychology; hospital therapy. occupational disease; polyclinic therapy, physiotherapy; traumatology, orthopedics; hospital surgery; neurosurgery; infectious diseases; anesthesiology, resuscitation, intensive care; dentistry; forensic Medicine; oncology, radiation therapy; clinical pathology; pediatric surgery; childhood infectious diseases; genetics, medical ecology; clinical immunology; surgical diseases. GPC-8 Is ready to apply pharma- Pharmacology; pharmacology in cardiol- ceuticals and other sub- ogy. stances and their combina- tions in medical practice for solving the professional tasks

PC-8 Capable of determining Propedeutics of internal diseases; general the tactics of managing pa- surgery; dermatovenereology; neurology; tients with various nosologi- faculty therapy; faculty surgery; urology; cal forms obstetrics and gynecology; otorhinolaryngology; ophthalmology; endocrinology; phthisiology; psychiatry, medical psychology; hospital therapy. occupational disease; polyclinic therapy, physiotherapy; traumatology, orthopedics; hospital surgery; neurosurgery; infectious diseases; anesthesiology, resuscitation, intensive care; dentistry; oncology, radiation therapy; pediatric surgery; clinical immunology; surgical diseases; gerontology and geriatrics in internology, topical issues of geriatric endocrinology; pharmacology in cardiology; sexually transmitted infections; inno- vative technologies in aesthetic dermatol- ogy; formation of professional compe- tences of a general practitioner / family doctor; palliative care for patients.

PC-20 Ready for analysis and pub- Faculty Therapy; faculty surgery; obstet- lic presentation of medical rics; gynecology; hospital therapy. occupa- information based on evi- tional disease; polyclinic therapy, physio- dence-based medicine therapy; hospital surgery; fundamentals of scientific work in medicine; Russian lan- guage as a means of professional commu- nication of a doctor; methodological problems of scientific research in medicine; training communicative competence of the doctor. PC-21 Able to participate in scien- Philosophy; medical informatics; public tific research health and healthcare, health economics; fundamentals of scientific work in medicine; methodological problems of scientific research in medicine

Contents of competencies (stages of competency formation) Stages of formation and indicators of attaining the Code of Definition of competency the com- the compe- Is proficient in (Has petency tency Knows Is able to practical experience in) GPC-4 Able and - moral, ethi- - put into - skills in the implementa- ready to im- cal and deon- practice ethi- tion of medical deontology plement ethi- tological cal and de- and medical ethics cal and deon- norms, rules ontological - skills to implement and tological and principles principles of protect one’s own rights principles in of profes- professional and the rights of patients professional sional and activity activities medical be- - apply the havior main ethical - the main documents ethical docu- of interna- ments of in- tional organ- ternational or- izations, do- ganizations, mestic and domestic and international international professional professional medical as- medical asso- sociations ciations - rights and obligations of patients and health care workers

- ways to communicate and interact with different age categories of patients, parents, col- leagues GPC-5 Is able and - the basis for - to analyze - the skills of analyzing the ready to ana- analyzing the the results of results of one’s medical lyze the re- results of one’s own activity and making con- sults of one’s one’s own ac- activity to clusions own activity tivity to avoid avoid medi- - the skills of applying the to avoid pro- professional cal mistakes methods of evidence- fessional mis- mistakes - to analyze based medicine in as- takes - normative diagnostic sessing the state of health documenta- and curative of adult population, the action concern- measures activity of medical institu- ing the re- cording to tions and in scientific re- sponsibility medical doc- searches of medical in- umentation - has the experience in an- stitutions and (case his- alyzing the data from med- medical per- tory) taking ical documents to verify sonnel for im- into consid- the diagnosis proper treat- eration the ment, profes- current pro- sional and of- cedures for ficial miscon- medical as- ducts sistance, - theoretical clinical rec- questions of ommenda- gathering, tions (treat- storing, seek- ment proto- ing, pro- cols) for cessing, and medical as- spreading sistance con- medical infor- sidering mation medical as- - potential sistance mistakes in standards medical prac- - to solve tice of various professional profile tasks inde- - the basis of pendently evidence- with the use

based medi- of all availa- cine ble informa- tive re- sources and to assess the results of one’s professional activity - to assess possible effects of professional mistakes GPC-6 Is ready to - principle - to fill in - the skills of drawing up maintain types of med- medical doc- medical documentation in- medical doc- ical documen- umentation, cluding computer version umentation tation, used in including - the skills of drawing up medical insti- computer working plans and reports tutions, in- version on work performed cluding while - to work managing pa- with per- tients sonal data of - rules of patients and drawing up information medical docu- which is mentation considered the medical confidential- ity - to draw up working plans and reports on work performed GPC-8 Is ready to - classifica- - to adminis- - the skills of administer- apply phar- tion and basic ter proper ing, applying, and as- maceuticals characteris- therapeutic sessing the effects of me- and other tics of phar- treatment ac- dicinal preparations in substances maceuticals, cording to management, rehabilita- and their pharm dy- the syn- tion and prevention of dif- combina- namics and dromes de- ferent diseases and patho- tions in med- pharm kinet- tected and logical conditions ical practice ics taking into

for solving consideration diagnosis - the skills of writing out the profes- age-related made prescriptions for medicinal sional tasks features - to give rea- preparations - indications sons for - the skills of rational and contrain- pharmaceu- pharm therapy dications for tical therapy using phar- in the patient maceuticals, with basic their side-ef- pathologic fects syndromes - general prin- and urgent ciples of pre- conditions scription for- -to write out malization prescriptions and composi- for pharma- tion of official ceuticals for medicinal definite dis- formulae eases and pathological processes PC-8 Capable of - tactics of - determine - skills of determining the determining managing pa- the tactics of tactics of maintaining and the tactics of tients with patients’ developing a treatment managing various noso- management plan for a disease or condi- patients with logical forms with various tion, taking into account various noso- - modern nosological the diagnosis, age and clin- logical forms methods of forms ical picture in accordance drugs admin- - draw up a with the existing medical istration, treatment care procedures, clinical medical de- plan for the guidelines (treatment pro- vices and disease and a tocols) on the issues of medical nutri- patient's medical care, taking into tion in case of condition, account the standards of diseases and taking into medical care patients’ con- account the ditions in ac- diagnosis, cordance with the patient's current medi- age, the clin- cal care pro- ical picture cedures, clini- of the dis- cal guidelines ease in ac- (treatment cordance protocols) on with the ex- medical care isting medi- issues, taking into account cal care pro- medical care cedures, standards clinical rec- - mechanism ommenda- of drugs, tions (treat- medical de- ment proto- vices and cols) on the medical nutri- issues of tion action, medical medical indi- care, taking cations and into account contraindica- the standards tions to their of medical use; compli- care cations caused by their use - modern methods of non-pharmacological treatment of diseases and conditions in accordance with the current medical care procedures, clinical guidelines (treatment protocols) on the issues of medical care, taking into account the standards of medical care - mechanism of action of non-drug treatment; medical indications and

contraindications to its appointment; side effects, complications caused by its use PC-20 Ready for - the basis of - to work in- - presentation skills of an analysis and the analysis of dependently independent point of view, public scientific and with the public speech, moral and presentation medical infor- sources of ethical argumentation, dis- of medical in- mation, tak- scientific cussion and round table formation ing into ac- and medical meetings based on count demon- information - skills of public presenta- demonstra- strative medi- - to make re- tion of medical infor- tive medicine cine, modern ports (report mation based on demon- theoretical sections), lit- strative medicine and experi- erature re- mental meth- views, re- ods of scien- ports on the tific research topic or its in medicine section (task - basic re- stage) quirements - to use sci- for the public entific and presentation medical in- of medical information, formation domestic and foreign experience, to put into practice knowledge and skills in the presentation of medical information based on demonstrative medicine PC-21 Able to par- - the methods - to partici- - skills of participation in ticipate in of organizing pate in the the solution of individual performance scientific re- scientific re- of scientific research and applied research search and as- research, to search tasks sessing the re- solve the - methods of statistical liability of the tasks set in processing of research re- obtained re- it, and evalu- sults sults ate the relia- - principles of the main la- - modern the- bility of the boratory equipment opera- oretical and obtained tion empirical data - the basics of using methods of - to formu- demonstrative medicine scientific re- late a scien- when conducting research search tific hypoth- - the funda- esis, to de- mentals of termine the statistical goals and methods ap- objectives of plication in scientific ac- biomedical tivity research - to apply - the role of modern the- various mod- oretical and eling methods empirical re- in the study- search meth- ing of patho- ods, make logical pro- calculations cesses, their on the re- capabilities, sults of their limitations usage, carry and perspec- out statisti- tives cal pro- - safety regu- cessing of lations when the data conducting - to plan and scientific re- participate in search carrying out (in compli- ance with the relevant rules) scientific experi- ments, process and analyze the results of ex- periments

- to use basic laboratory equipment, to plan laboratory research

3. Topics of the discipline and competencies formed during their study

Name of the topic of the Contents of the topic Code of the competency discipline Evidence-based medicine. GPC- 4, GPC-5, GPC-6 Definition. Formulary drug GPC-8, PC-8, PC-20, supply system, its goals. For- Evidence-based medi- PC-21. mulary Therapeutic Commit- cine. Formulary treat- tee. The concept of pharmaco- ment of diseases. economics and pharmacoepi- Pharmacoeconomics. demiology. Methods of phar- Pharmacoepidemiology. macoeconomic analysis. Principles of clinical research planning. Clinical pharmacology. Defi- GPC- 4, GPC-5, GPC-6 nition. Subject and goals. GPC-8, PC-8, PC-20, Basics of clinical phar- Pharmacokinetics of drugs. PC-21. macology. Principles of Basic laws, parameters. The rational use of drugs. concept of pharmacodynamics. Methods of assessing drug PK and PD. Age aspects of clinical Features of pharmacotherapy GPC-8, PC-8, PC-20, pharmacology. Drug In- in children age, with diseases PC-21. teractions. Problems of of the liver and kidneys. combined pharma- Basics of combined cotherapy. pharmacotherapy. The Pharmacogenetics. concept of pharmacogenetics. Classification of undesirable GPC- 4, GPC-5, GPC-6, effects of drugs. Definitions of GPC-8, PC-8, PC-20, Adverse drug reactions main side effects (drug over- PC-21. (side effects of drugs). dose, immediate negative Principles of rational pharmacological action, sec- use of drugs in lactating ondary side effects, idiosyn- and pregnant. crasy, drug allergy, teratog- enous action). Mechanisms of development, pathogenesis

and clinical picture of side effects. Prevention and treatment of side effects manifesta- tions. Features of pharmacotherapy during pregnancy and lactation. Drug safety categories on the FDA system. Pharmacodynamics and the GPC- 4, GPC-5, GPC-6, pharmacokinetics, side ef- GPC-8, PC-8, PC-20. fects, indications and contraindications to drugs affecting the secretory function of gas- Clinical pharmacology trointestinal tract; antimicrobi- of agents affecting the als; antacids; alginates; tissue digestive organs. The regeneration stimulants; gas- principles of modern tro-and hepatoprotectors; pharmacotherapy. choleretics; antispasmodics, prokinetics; enzymes; antie- metics; laxatives; drugs used in diarrhea. The choice of the above medicines for gastrointestinal diseases treatment. Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, macodynamics, side effects, GPC-8, PC-8, PC-20. approaches to the use, indications and contraindications to drugs used in ischemic heart Clinical pharmacology disease: nitrates and syd- of antianginal drugs, li- nonimine; beta blockers; cal- pid-lowering drugs and cium channel blockers; inhibi- antithrombotic agents. tors of If-channels; potassium The principles of channel activators; myocardial modern cytoprotectors. Pharmacody- pharmacotherapy of namics and the pharmacoki- coronary heart disease. netics, side effects, indications and contraindications to poli- pidemcs, antithrombotic drugs. Rational combination therapy. Clinical pharmacology Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, of drugs used to treat macodynamics, side effects, GPC-8, PC-8, PC-20. heart failure. Clinical approaches to the use, indica- pharmacology of anti- tions and contraindications to arrhythmic drugs. drugs used in CHF: ACE in- Principles of modern pharmacotherapy of hibitors, diuretics, cardiac gly- circulatory failure and cosides, beta-blockers, sar- arrhythmias. tans. Rational combination therapy. Algorithm for treatment of patients with CHF. Pharmacodynamics and pharmacokinetics, side effects, indications and contraindications to antiarrhythmic drugs, beta-blockers, antiadrenergic drugs, calcium channel blockers. Algorithms of arrhythmias treatment. Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, macodynamics, side effects, GPC-8, PC-8, PC-20. approaches to the use, indications and contraindications to antihypertensive drugs: beta- Clinical pharmacology blockers, diuretics, calcium of antihypertensive channel blockers, angiotensin drugs. Principles of converting enzyme inhibitors, modern pharmacother- angiotensin receptor antago- apy of arterial hyperten- nists, agonists of central imid- sion. azolin receptors, alpha adre- noblockers,direct renin inhibitors. Rational combination of antihypertensives. Treatment of hypertensive crisis. Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, macodynamics, side effects, GPC-8, PC-8, PC-20. indications and contraindications to bronchodilators (beta- Clinical pharmacology adrenergic agonists, of drugs used in pulmo- methylxanthines, inhibitors of nology . Principles of bronchoconstriction atropino- modern pharmacother- voy group) and drugs for anti apy of bronchial asthma farmakoter and FDI (stabi- and COPD. lizers of mast cell membranes antileukotriene drugs, gluco- corticoids ) . For patients with bronchial asthma , COPD . Clinical pharmacology Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, of anti-inflammatory macodynamics, side effects, GPC-8, PC-8, PC-20. drugs, cytostatics and indications and contraindica- immunostimulants.

Principles of modern tions to glucocorticoid hor- pharmacotherapy of mones, salicylic acid deriva- rheumatic diseases. tives, pyrazolone derivatives, indole derivatives, phenyla- cetic acid derivatives; alka- noic acid derivatives, aminoquinoline derivatives, coxibs, oxycams; other COX inhibitors. Pharmacotherapy algorithm for rheumatic diseases . Pharmacokinetics and phar- GPC- 4, GPC-5, GPC-6, macodynamics, side effects, GPC-8, PC-8, PC-20. indications and contraindications to natural penicillins, streptomycin, chlorampheni- col, tetracycline, semisyn- Clinical pharmacology thetic penicillins, cephalo- of antibacterial drugs. sporins carbapenems , mac- Principles of modern rolides, aminoglycosides, gly- pharmacotherapy of the copeptides , quinolones , sul- infectious process. fonamides, metronidazole, ni- trofurans , antigungal drugs, antiviral drugs. Rules of combined antibiotic therapy. Al- gorithms of antibacterial treatment in the infectious process.

4. Plan of studying topics of the discipline (in academic hours)

Forms of Applied current ac- teaching ademic technolo- achieve- Individual Total gies, means ment as- Contact work work (self- hours and meth- sessment instruction) ods of teach- and inter- Name of topic of the ing mediate at- discipline testation

including In- To- prac- lec- Tradi- ter- tal tical tures clas- tional ac- ses tive Evidence-based medi- 6 2 4 2 8 PC, PL T, I, ACC cine. Formulary treat- CD, ment of diseases. CH, Pharmacoeconomics. SSRW, Pharmacoepidemiology. SRW Basics of clinical phar- 7 2 5 2 9 PC, PL T, I, ACC macology. Principles of CD, rational use of drugs. CH, SSRW, SRW, Age aspects of clinical 5 1 4 2 7 PC, PL T, I, ACC pharmacology. Drug In- CD, teractions. Problems of CH, combined pharma- SSRW, cotherapy. Pharmacogenetics. SRW, Adverse drug reactions 6 1 5 2 8 PC, PL T, I, ACC (side effects of drugs). CD, Principles of rational CH, use of drugs in lactating SSRW, and pregnant. SRW, Clinical pharmacology 8 8 1 9 PC, PL T, I, ACC, of agents affecting the CD, Pr. digestive organs. The CH, principles of modern SSRW, pharmacotherapy. SRW, ST

Clinical pharmacology 7 1 6 5 12 PC, PL T, I, ACC, of antianginal drugs, li- CD, Pr. pid-lowering drugs and CH, antithrombotic agents. SSRW, The principles of modern SRW, pharmacotherapy of ST coronary heart disease. Clinical pharmacology 7 1 6 5 12 PC, PL T, I, ACC, of drugs used to treat CD, Pr. heart failure. Clinical CH, pharmacology of anti- SSRW, arrhythmic drugs. Principles of modern SRW, pharmacotherapy of ST circulatory failure and arrhythmias. Clinical pharmacology 6 6 5 11 PC, PL T, I, ACC, of antihypertensive CD, Pr. drugs. Principles of CH, modern pharmacother- SSRW, apy of arterial hypertension. SRW, ST Clinical pharmacology 7 1 6 5 12 PC, PL T, I, ACC, of drugs used in pulmo- CD, Pr. nology . Principles of CH, modern pharmacother- SSRW, apy of bronchial asthma and COPD. SRW, ST Clinical pharmacology 6 6 3 9 PC, PL T, I, ACC, of anti-inflammatory CD, Pr. drugs, cytostatics and CH, immunostimulants. SSRW, Principles of modern pharmacotherapy of SRW, rheumatic diseases. ST Clinical pharmacology 5 1 4 4 9 PC, PL T, I, ACC, of antibacterial drugs. CD, Pr., DCH Principles of modern CH, pharmacotherapy of the SSRW, infectious process. SRW, ST Credit-test 2 2 2 Т, Pr., С Total: 72 10 62 36 108

4.1. Applied teaching technologies, means and methods of teaching PL* problem CD** case discussion lecture PC** practical CH** Filling in a case history class ST** Solving SSRW** students'scientific research work (compilation of an in- situa- formational review of literature on the proposed tional topics) tasks SRW** student research work

4.2. Forms of current academic achievement assessment and intermediate attestation

ACC analysis of clinical cases (clin- I assessment based on interview re- ical analysis) sults (oral survey) Т testing DCH defense of case history Pr. assessment of the development of practical skills (skills, possessions)

5. Educational, methodical and informational support of the discipline

5.1. Main literature:

1. Wirfs MJ. The APRN’s Complete Guide to Prescribing Drug Therapy 2018. New York, NY: Springer Publishing Company; 2017. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1521652&lang=ru&site=ehost-live 2. Methodical textbook of clinical pharmacology for self-traning of the students of pharmaceutical faculty [Текст] / N. G. Philippenko. - Kursk : KSMU, 2002. - 37 p. 3. Methodical textbook of clinical pharmacology for self-training of 5-th year medical students [Текст] / G. S. Mal. - Kursk : KSMU, 2002. - 20 p. 4. Клиническая фармакология [Электронный ресурс] : учебник / под ред. В. Г. Кукеса, Д. А. Сычева. - 5-е изд., испр. и доп. - М. : ГЭОТАР-Медиа, 2017. – 1024с. - – URL: http://www.studentlibrary.ru/book/ISBN9785970441961.html 5. Клиническая фармакология и фармакотерапия в таблицах, схемах и алгорит- мах (разделы: доказательная медицина, формулярная система лечения забо- леваний, основы клинической фармакологии, кардиология): учеб. пособие для врачей, клин. интернов, ординаторов, аспирантов, студентов мед. и фар- мацевт. вузов / Н. Г. Филиппенко [и др.] ; Курск. гос. мед. ун-т. - 2-е изд. - Курск : Изд-во КГМУ, 2009. - 164 с. : ил. (электронная версия в библиотеке КГМУ). – URL: \\10.0.0.151\fulltext\Издания КГМУ\Филиппенко Н.Г\Клин. фармакология .pdf

5.2. Additional literature:

1. Aaronson E, Venkatesh A, Antonsen E, Walls RM, Adler J. Emergency Medicine Evidence : The Practice-Changing Studies. Philadelphia, Pa: Wolters Kluwer Health; 2015. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1473187&lang=ru&site=ehost-live 2. Arnett DK, Shah S. Cardiovascular Genetics and Genomics in Clinical Practice. New York: Demos Medical; 2015. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=881028&lang=ru&site=ehost-live 3. Amyes SGB. Antibacterial Chemotherapy : Theory, Problems, and Practice. Ox- ford: OUP Oxford; 2010. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=405993&lang=ru&site=ehost-live 4. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. [Place of publication not identified]: Wolters Kluwer Health; 2016. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1857599&lang=ru&site=ehost-live 5. Murrell KE. Urinary Tract Infections : Epidemiology, Pathogenesis and Preven- tion. New York: Nova Science Publishers, Inc; 2014. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=710389&lang=ru&site=ehost-live 6. Rao R, Suster S, Moran C. Pulmonary Pathology. New York: Demos Medical; 2014. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=699490&lang=ru&site=ehost-live 7. Riddell RH, Jain D, Bernstein CN, Guha S, Lewin K. Lewin, Weinstein and Rid- dell’s Gastrointestinal Pathology and Its Clinical Implications. Vol Second edition. Philadelphia, PA: Wolters Kluwer Health; 2014. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1473063&lang=ru&site=ehost-live

8. Steinberg BA, Cannon CP. Evidence-Based Cardiology. Vol 4th ed. Philadelphia: Wolters Kluwer Health; 2015. – URL: http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1473054&lang=ru&site=ehost-live 9. Бронхообструктивный синдром - индивидуальный выбор лекарственной те- рапии в соответствии с протоколами ведения больных. Принципы фармако- терапии аллергических заболеваний [Электронный ресурс] : учеб.-метод. по- собие / Н. Г. Филиппенко, С. В. Поветкин, С. И. Корнеева ; Курск. гос. мед. ун-т. - Электрон. текстовые дан. - Курск : КГМУ, 2015. - 1 эл. опт. диск (CD- ROM) (электронная версия в библиотеке КГМУ). – URL:: ftp://fulltext.kursksmu.net/fulltext/Electron_publications_KSMU/2015/17674.7z 10. Выбор противоинфекционной фармакотерапии в клинике внутренних болез- ней. Протоколы ведения больных [Электронный ресурс] : учеб.-метод. посо- бие / Н. Г. Филиппенко, С. В. Поветкин, О. В. Левашова ; Курск. гос. мед. ун- т. - Электрон. текстовые дан. - Курск : КГМУ, 2015. - 1 эл. опт. диск (CD- ROM) (электронная версия в библиотеке КГМУ). – URL: ftp://fulltext.kursksmu.net/fulltext/Electron_publications_KSMU/2015/17673.7z 11. Клиническая фармакология и фармакотерапия в таблицах, схемах и алгорит- мах (разделы: пульмонология, аллергология): учеб. пособие для врачей, клин. интернов, ординаторов, аспирантов, студентов мед. и фармацевт. вузов / Н. Г. Филиппенко, С. В. Поветкин ; Курск. гос. мед. ун-т. - Курск : Изд-во КГМУ, 2009. - 90 с. : ил. (электронная версия в библиотеке КГМУ). – URL:: ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2009/FilippenkoNG/Filippen- koNG_Klin_farmakol_2009.pdf 12. Рациональная фармакотерапия заболеваний мочевыводящих путей у бере- менных и кормящих женщин: научное издание / Н. Г. Филиппенко, С. В. По- веткин, А. А. Корнилов [и др.]; под ред. Н. Г. Филиппенко ; Курск. гос. мед. ун-т; Ком. здравоохранения Курской обл. - Курск : Изд-во КГМУ, 2012. - 52 с. - (Конспект практическому врачу). - Библиогр.: с. 51-52(20 назв.). (элек- тронная версия в библиотеке КГМУ). – URL: ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2012/463/463.pdf

13. Современные алгоритмы фармакотерапии аритмий [Электронный ресурс] : мультимедийное учеб. пособие / С. В. Поветкин [и др.] ; Курск. гос. мед. ун- т, каф. клин. фармакологии. - Электрон. текстовые дан. - Курск : КГМУ, 2017. - 1 эл. опт. диск. (электронная версия в библиотеке КГМУ). – URL: ftp://fulltext.kursksmu.net/fulltext/Electron_publica- tions_KSMU/2017/0321702430.7z

5.3. Periodicals:

1. Клиническая фармакология и терапия. 2. Рациональная фармакотерапия в кардиологии. 3. Кардиоваскулярная терапия и профилактика. 4. Российский кардиологический журнал. 5. Пульмонология.

5.4. Electronic information support and professional databases:

1. Guidelines of the European Society of Cardiology in English. Electronic resource: https://www.escardio.org/Guidelines 2. Guidelines of the European Respiratory Society in English. Electronic resource: www.ers-education.org/guidelines.aspx 3. Guidelines of the World Society of Gastroenterology in English. Electronic resource: http://www.worldgastroenterology.org/guidelines/global-guidelines 4. Guidelines of the European Antirheumatic League in English. Electronic resource: https://www.ncbi.nlm.nih.gov/pubmed/?term=guidelines%20EULAR 5. Cochrane Collaboration. Electronic resource: http://www.cochrane.org 6. Cochrane Library. Electronic resource: http://www.thecochraneli- brary.com/view/0/index.html 7. Consultant Plus https://kurskmed.com/department/library/page/Consult- ant_Plus

8. Database of international scientific citation index "WEB OF SCIENCE". Electronic resource: http://www.webofscience.com 9. Full-text database "Medline Complete". Electronic resource: http://search.ebscohost.com/ 10. World Health Organization. Electronic resource: http://www.who.int/

6.Material-technical support of the discipline

No. Names of special rooms and Equipment of special rooms and rooms for in- List of licensed program support. Requisites of rooms for individual work dividual work confirming document 1. Russian Federation, 305004, Classroom for lecture-type classes (210 m): spe- Kursk, Semyenovskaya str.76, 2nd cialized furniture (sections of chairs, lecturers' trib- entrance, 4th floor, conference une); technical training tools that serve to present room information to a large audience ( multimedia pro- jector, laptop). 2. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 1st individual consultations, current control and in- entrance, 2nd floor, study room №1 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (personal computer, multifunctional printer); visual aids, providing thematic illustrations. 3. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 2nd individual consultations, current control and in- entrance, 3rd floor, study room №2 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (laptop, MFP); visual aids, providing thematic illustrations. 4. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 1st individual consultations, current control and in- entrance, 3rd floor, study room №3 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (laptop, MFP); providing thematic illustrations. 5. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 2nd individual consultations, current control and in- entrance, 5th floor, study room №4 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (laptop, MFP); visual aids, providing thematic illustrations.

6. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 1st individual consultations, current control and in- entrance, 3rd floor, study room №5 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (laptop, TV); visual aids, providing thematic illustrations. 7. Russian Federation, 305004, Learning room for seminar classes, group and Kursk, Semyenovskaya str.76, 1st individual consultations, current control and in- entrance, 3rd floor, study room №6 termediate attestation: specialized furniture (educational furniture, cabinets); technical training equipment and demonstration equipment (laptop, MFP); visual aids, providing thematic illustrations. 8. Russian Federation, 305004, Rooms for independent work of students, 1. The program for creating tests - Adit Testdesk , Kursk, Semyenovskaya str.76, 2nd equipped with computer equipment and the contract number 444 from 06/22/2010 entrance, 4th floor, display class ability to connect to the Internet and provide ac- 2. The program for the organization of distance cess to the organization’s electronic information learning - ISpring Suite 7.1, contract number 652 and educational environment: specialized furni- from 09/21/2015 ture, technical equipment (personal computers). 3. Office software package - Microsoft Win Office Pro Plus 2010 RUS OLP NL , contract No. 548 dated August 16, 2010 4. Operating system - Microsoft Win Pro 7, contract No. 904 of 12/24/2010 5. Antivirus - Kaspersky Endpoint Security, contract number 832 of 10/15/2018 6. Office software package - MyOffice Education, contract number 733 of 09/17/2018 7. Office software package - MyOffice Standard, contract No. 733 dated 09/17/2018 8. Library Automation System IRBIS 64, Contract No. 865 dated 10.22.2018 9. Web service for video conferencing - Imind , contract number 632 from 08.27.2018 9. Russian Federation, 305004, Premises provided for the provision of medical Kursk, Semyenovskaya str.76, ad- care to patients, including those associated with mission department medical interventions, equipped with specialized

equipment and (or) medical products: tonometer, stethoscope, stetofonendoskop, medical ther- mometers, stadiometer medical, antishock kit, set for emergency preventive and therapeutic measures . 10. Russian Federation, 305004, Premises provided for the provision of medical Kursk, Semyenovskaya str.76, car- care to patients, including those associated with diology department medical interventions, equipped with specialized equipment and (or) medical products: 6-channel ECG Cardiovit AT-2, 3-channel ECG Cardimax FX -7102, Holter ECG Valenta , stethoscope, express - measuring instrument of blood glucose con- centration portable PCG "Satellite Express Z834", pulse oximeter, medical thermometer, wheel chair, rubber band, antishock set, tonometer , ne- gatoscope. 11. Russian Federation, 305004, Premises provided for the provision of medical Kursk, Semyenovskaya str.76, de- care to patients, including those associated with partment of functional and ultra- medical interventions, equipped with specialized sound diagnostics equipment and (or) medical products: ECG 6- channel Cardiovit AT-2, ECG 3-channel Cardimax FX- 7102, Holter ECG Valenta, SMBP MNSDP, VEM Valenta, Reograf Valenta, ultrasound scanner VIVID 7, ultrasound scanner SonoScape

7. Assessment tools

Questions for the oral part of the credit-test

1. Pharmacotherapy. Subject and tasks. The basic principles of modern drug therapy. 2. The concept of drugs bioavailability. The main directions of increasing the bioavailability of drugs. 3. The absorption of drugs. General patterns. Factors affecting absorption and ways to optimize it. 4. Transport, distribution of medicinal substances in the human body and the influence of various factors on them. 5. General patterns of biotransformation of medicinal substances in the human body and their determining factors. 6. General patterns of excretion of medicinal substances in the human body and their determining factors. 7. General rules for taking medication depending on the diet. 8. Features of pharmacokinetics of drugs in childhood. 9. Features of pharmacokinetics of drugs in the elderly and senile age. 10. The concept of physical and chemical incompatibility of drugs. 11. Formulary system for providing medicinal products. 12. General patterns of combined pharmacotherapy. 13. Evidence-based medicine. 14. Side effects of drugs. 15. Adverse drug reactions. Allergic reactions. Reasons, ways of prevention and treatment. 16. Adverse drug reactions caused by the direct pharmacological action of drugs. 17. Pharmacoepidemiology and pharmacoeconomics. 18. The general concept of clinical pharmacology. Pharmacokinetics and pharmacodynamics of drugs. 19. Pharmacogenetics. 20. Characteristics of beta-blockers.

21. Modern principles of medicinal treatment of pyelonephritis, cystitis. 22. Characteristics of angiotensin-converting enzyme inhibitors. 23. Modern principles of drug treatment of osteoarthritis deformans. 24. Characterization of antagonists of angiotensin receptors. 25. Modern principles of drug treatment of rheumatoid arthritis. 26. Characteristics of diuretics. 27. Modern principles of drug treatment of gastritis. 28. Characteristics of calcium channel blockers. 29. Modern principles of drug treatment of gastric ulcer and duodenal ulcer. 30. Characteristics of nitrovasodilators. 31. Modern principles of medicinal treatment of bronchial asthma. 32. Characteristics of antiarrhythmic drugs. 33. Modern principles of drug treatment of pneumonia. 34. Characteristics of bronchodilating agents. Adrenomimetics. 35. Modern principles of drug treatment of circulatory failure. 36. Characteristics of bronchodilating agents. M-cholinolytics. 37. Modern principles of drug treatment of arterial hypertension. 38. Characteristics of antisecretory anti-ulcer agents. Blockers of H2-histamine receptors. 39. Modern principles of drug treatment of COPD. 40. Characteristics of antisecretory anti-ulcer agents. Proton pump inhibitors. 41. Modern principles of medicinal treatment of ischemic heart disease. 42. Characteristics of aminoglycosides, tetracyclines. 43. Modern principles of pharmacotherapy of supraventricular and ventricular tachycar- dias. 44. Characteristics of penicillins. 45. Modern principles of pharmacotherapy of acute myocardial infarction. 46. Characteristics of cephalosporins, carbapenems. 47. Modern principles of pharmacotherapy of chronic cholecystitis. 48. Characteristics of macrolides, glycopeptides.

49. Modern principles of pharmacotherapy of chronic pancreatitis. 50. Characteristics of glucocorticosteroid hormones. 51. Modern principles of pharmacotherapy for GERD. 52. Ways to increase the effectiveness of pharmacotherapy in patients with impaired elimination of drugs. 53. Characteristics of nonsteroidal anti-inflammatory drugs. 54. Modern principles of pharmacotherapy of irritable bowel syndrome. 55. Characteristics of choleretic and enzyme preparations. 56. Modern principles of pharmacotherapy of atrial fibrillation. 57. Characteristics of cytostatic agents. 58. Modern principles of pharmacotherapy extrasystole. 59. Characteristics of quinolones and monobactams. 60. Modern principles of pharmacotherapy of gout

Bank of profession-oriented situational problems for the credit-test

Problem № 1. Diagnosis: Congenital heart disease: IVS defect. CHF1 FC. Per os Parenterally

Tab. Hydrochlorothiazidi 25mg in the morning Aethylmethylhydroxypyridini succinas 1ml + i/v Tab. Losartan 50 mg in the evening Inosini 200mg

Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №2 Diagnosis: CHD: stable angina pectoris, FC II. CHF III FC. Per os Parenterally Tab. Metoprololi 100 mg 1 time per day

Furosemidi 40mg Tab. Acidi acetylsalicylici 150mg three times + i/v Nitroglycerini 1ml 1% a day

Tab. Enalaprili 10 mg 2 times a day Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №3 Diagnosis: CHD: PICS. CHF IV FC. Recurrent cardiac asthma. Per os Parenterally

Tab. Isosorbidi mononitras 40 mg 2 times a day Furosemidi 80mg + Tab. Spironolactoni 50mg in the morning Sol. Nitroglycerini 1% 1ml + Tab. Simvastatini 40 mg 2 times a day 200ml isotonic solution

Questions. 1. Are indicated doses, routes of administration, time of reception correct?

2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №4 Diagnosis: COPD, bronchitic variant. Resp. insufficiency 3. Per os Parenterally

Carbocisteini 2 capsules 3 times a day Prednisoloni 60mg+

Amoksiklavi 500mg 3 times a day Fluticasone 500 mg 2 times per day by in- + halation 200ml isotonic solution Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №5 Diagnosis: Bronchial asthma, mixed, severe course, without exacerbation. Per os Parenterally

Tab. Montelukast 10mg in the morning Prednisoloni 120mg

+ i/v Tab. Bromhexin 8 mg 4 times a day Sol. Aminophyllini 2,4% 5ml

1-2 Fenoteroli 200 ug dose (inhaled) at attacks

Problem №6 Diagnosis: Duodenal ulcer, exacerbation. Per os Parenterally

S. Cerucali 1,0 T. Omeprazoli 20mg x 2 p \ day Platiphyllini hydrotartratis 1,0 - 0,2% / i/m in a T. Clarithromycini 500mg x 2p \ day single syringe

Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible?

3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №7 Diagnosis: Stomach ulcer. H. pylory revealed resistance to clarithromycin. Per os Parenterally

T. Omeprazoli 20mg x 2 p \ day S. Drotaverini 2 ml i/m in one syringe T.Metronidazoli 500mg x 3p \ g S. Cerucali 1,0 Bismuth dicitratis 120mg x 4p \ d

Problem №8 Diagnosis:Chronic pyelonephritis, worsening. CKD 1. Per os Parenterally

Cefazolini 1000mg tab. Diclophenaci 50 mg 2 times a day + Kanamycin 500 mg drip 2 t / d tab. Furosemidi 40mg in the morning + 200.0 0.9% NaCl solution

Problem №9 Diagnosis: Acute bacterial rhinosinusitis. Per os Parenterally tab. Loratadine 10 mg 1 time per day Cefotaximi 1000mg + tab. Acetylcysteini 200 mg 2 times a day Clarithromycini 1000mg (dissolved in 1 cup water) 3 times per day in one set Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible?

Problem №10 Diagnosis: Nosocomial pneumonia is the lower lobe of the left lung, severe course.

Per os Parenterally

tab. Diclophenaci 100 mg 1 time per day Levofloxacini 500mg + Ceftriaxone 1000mg / drip tab. Ambroxoli 30mg 3 times per day + 200.0 0.9% NaCl solution Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №11 Diagnosis: CHD: Stable angina IIIFC. CHF II FC.

Per os Parenterally Tab. Nifedipini 0,01 Sol. Nitroglycerini 1% -1.0 ml per 200ml 0,9% 1tabl. 3 times a day before meals. NaCl / drip (5-7 drops per minute). Tab. Isosorbidi mononitrati 0,05 in the morning every day. Sol. Furosemidi 40 mg / i/v Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №12 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4. Hypertensive crisis. CHF IIIFC.

Per os Parenterally Tab. Telmisartani 40mg Sol. Enalaprilati 1,25mg 1tabl. 1 in the morning every day. / drip in 200.0 ml 0,9% Nacl.

Tab. Bisoprololi 5mg Sol. Furostmidi in 40mg / jet. 1tabl. 1 in the morning every day.

Problem №13 Diagnosis: Gestational hypertension. Heart rate of 120-130 beats per minute at rest. Pregnancy 28 weeks. Per os Parenterally Tab. Enalaprili 5mg Sol. Cordaroni 450 mg / drip 200.0 5% glu- 1tabl. 2 times a day. cose.

Tab. Bisoprololi 2,5 mg Sol. Enalaprilati 1,25mg 1tabl. morning. / drip in 200.0 ml 0,9% Nacl.

Problem №14 Diagnosis: OA of the knee, IIIst. Secondary synovitis. Chronic gastritis with hypersecretion syndrome. Per os Parenterally

T. Meloxicami 15 mg during meals x 1p \ d S. Aflutopi 1 ml Almagel 1d.l x 3times a day for 30 minutes S.Diclophenaci 3.0 ml in \ m. before a meal In one syringe Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №15 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4.CHF II FC. Atherosclerosis of the lower extremities. Per os Parenterally Tab. Betaxololi 20mg Sol. Enalaprilati 1,25mg / drip in 200.0 ml ½ tab. morning 0,9% Nacl.

Tab. Perindoprili 10 mg Sol. Furosemidi 40mg / i/v. 1 tab. morning

Tab. Amlodipini 10mg 1 tab. in the morning every day. Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №16 Diagnosis: CHD: Acute myocardial infarction anterior left ventricular wall. CHF FC II. Per os Parenterally Tab. Metoprololi succinati 200mg Sol. Nitroglycerini 1% -1.0 ml per 200ml 0,9% Table 1. 1 time per day in the morning. Nacl / drip (5-7 drops per minute).

Tab. Acetylsalicylici acidi 75 mg Sol. Dalteparini sodiumi 10000ME subcutan. 1 tabl. evening. every 12 hours.

Problem №17 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4.CHF II FC. Atherosclerosis of the lower extremities. Per os Parenterally Tab. Betaxololi 10mg Sol. Enalaprilati 1,25mg ½ tab. morning / drip in 200.0 ml 0,9% Nacl.

Tab. Perindoprili 10 mg Sol. Furosemidi 40mg i/v.

Tab. Amlodipini 5 mg 1 tabl. in the morning every day. Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №18 Diagnosis: Acquired pneumonia of the lower lobe of the left lung. Per os Parenterally Tab. Amoxicillini 500 mg Sol. Cefotaximi 1g 2 times a day i/m. 1tabl. 3 times a day. Sol. Gentamicini 80 mg 2 times a day i/v. Tab. Ambroxoli 30mg 1 pill 3 times a day. Questions. 1. Are indicated doses, routes of administration, time of reception correct? 2. Are drugs chemically compatible? 3. Are drugs pharmacologically compatible? 4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism, excretion of drugs? 5. Suggestions for optimization of treatment (exclude, replace).

Problem №19 Boy P ,, 16 years. Carried out routine vaccination. After administration of the vaccine, appeared after 2 weeks temperature up to 39 degrees, skin rashes, joint pain, muscle weakness, increased peripheral lymph nodes, nephritis phenomenon.

1) What type of side effect occurs? 2) What is the mechanism of this side effect? 3) Name drugs with similar side effects. 4) What is the principle of providing emergency care? 5) Suggestions for optimizing treatment.

Problem №20 Diagnosis: Chronic pyelonephritis, worsening. Pregnancy 15 weeks. Per os Parenterally

Kanefron 2p 3 times a day S. Cefotaximi 1g x 2t \ d i\ m Tabl. Furagini 0,05 S. Gentamicini 1,0 ml x 2t \ d i\ m 2 tabl. 3 times a day after meals

Base of typical test tasks for the credit-test (complete base of test tasks is kept at the department and in the testing center)

1. PROVIDE YOUR ANSWER

DUAL-CHAMBER MODEL OF DRUG DISTRIBUTION IS CHARACTERIZED BY:

() drug accumulation in any organ or tissue

() drug, once in the central chamber, then enters into the peripheral chamber

() uniform distribution of drug in the body

2. PROVIDE YOUR ANSWER

FIRST STAGE OF TRANSFORMATION OF DRUGS IN THE BODY

() breeding

() absorption

() distribution

() adsorption

() metabolism

3. PROVIDE YOUR ANSWER

THIRD STAGE OF TRANSFORMATION OF DRUGS IN THE BODY

() metabolism

() adsorption

() absorption

() breeding

() distribution

4. SPECIFY THE APPROPRIATE

CLASS OF RECOMMENDATIONS CHARACTERISTIC IIA class a distinct preponderance of data on the use and effectiveness class I less obvious preponderance of data on the benefits and effi- ciency class IIB a high level of evidence or general agreement about the benefit, use and effectiveness of the pro- cedure and the method of treatment IV class diagnostic methods or treatment, for which there is evidence and/or general agreement about inefficiency

5. SPECIFY THE APPROPRIATE

LEVELS OF EVIDENCE CHARACTERISTIC C data descriptive studies, cross- sectional, expert agreement A small randomized trials B multicenter studies

SELECT THE CORRECT ANSWER FROM A LIST

CHAPTER OF CLINICAL PHARMACOLOGY, STUDIED STAGE OF PASSING THE MEDICAMENT OF THE ORGANISM CALLED ______.

7. PROVIDE YOUR ANSWER

ALDOSTERONE ANTAGONISTS ARE:

() mannitol

() indapamide

() eplerenone

() hydrochlorothiazide

() torasemide

8. PROVIDE YOUR ANSWER

DRUGS THAT CAN BE ADDED IN CHF IN PATIENTS WITH THE INEFFECTIVENESS OF MAXIMUM DOSES OF BETA-BLOCKERS FOR THE NORMALIZATION OF HEART RATE IN SINUS RHYTHM:

() amlodipine

() trimetazidine

() eplerenone

() torasemide

() ivabradine

9. SPECIFY THE APPROPRIATE GROUP OF DRUGS DRUGS ACEI fosinopril angiotensin II receptor blocker betaxolol selective beta-blocker candesartan

10. SPECIFY THE APPROPRIATE GROUP OF DRUGS DRUGS angiotensin II receptor blocker bisoprolol ACEI telmisartan selective beta-blocker zofenopril

11. SPECIFY THE APPROPRIATE CLASSES OF ANTIARRHYTHMIC DRUGS DRUGS II propranolol Ia lidocaine novokainamid propafenone

12. PROVIDE YOUR ANSWER

IA ANTIARRHYTHMIC DRUGS CLASS IS ...

() diltiazem

() quinidine

() etatsizin

() sotalol

() mexiletine

13. PROVIDE YOUR ANSWER

WHAT TYPE OF ADVERSE REACTIONS IS REFLEX NEGATIVE EFFECTS OF DRUGS RELATED TO:

() idiosyncrasy

() toxic effect

() secondary

() direct side effects

() intolerance

14. PROVIDE YOUR ANSWER

WHAT TYPE OF ADVERSE REACTIONS IS DYSBIOSIS RELATED TO:

() direct side effects

() intolerance

() idiosyncrasy

() secondary

() toxic effect

15. SPECIFY THE APPROPRIATE GROUP OF DRUGS DRUGS cytostatics dexamethasone glucocorticosteroids krizanol mercaptopurine

16. SPECIFY THE APPROPRIATE GROUP OF DRUGS DRUGS immunostimulants T-activin

4-aminoquinoline derivatives Plaquenil

17. PROVIDE YOUR ANSWER

DRUG INTERACTIONS BEFORE THE INTRODUCTION OF BODY CALLED:

() pharmaceutical

() pharmacodynamic

() pharmacokinetic

() antagonism

18. SPECIFY THE APPROPRIATE

INTERACTIONS DEFINITION antagonism effect of the combination is less than that of one or more components synergy combination effect is the action of one of the components indifference effect of the combination is greater than the effect of each component separately

19. SPECIFY THE APPROPRIATE

GROUPS OF DRUGS DRUGS drugs forming the protective sucralfate film drugs which inhibit acid secre- carbenoxolone tion almagel omeprazole

20. SPECIFY MULTIPLE CORRECT ANSWER PROTON PUMP INHIBITORS:

[] lansoprazole

[] omeprazole

[] famotidine

[] metoclopramide

[] de-nol

21. PROVIDE YOUR ANSWER

MODE OF IVABRADINE ACTION:

() increasing slow calcium current into the cell

() blockade slow calcium channels of the cell membrane

() increase in the activity of beta-receptors of the vascular wall of the coronary arteries

() If-channel blockade

() relaxation of smooth muscles in the vascular wall due to the formation of nitric oxide

22. PROVIDE YOUR ANSWER

NICORANDIL IS ...

() potassium channel activator

() blocker of late sodium ion current

() If-channel inhibitor

() beta-blocker

() prolonged nitrate

23. SPECIFY THE APPROPRIATE

GROUPS OF DRUGS DRUGS aminoglycosides gentamicin tetracyclines amikacin doxycycline

24. SPECIFY THE APPROPRIATE

DISEASE THE DRUG OF CHOICE exacerbation of COPD in pa- levofloxacin tients younger than 65 years COPD exacerbation with risk amoxicillin / clavulanate factors for infection with P. ae- ruginosa COPD exacerbation in patients amoxicillin older than 65 years

25. SPECIFY THE APPROPRIATE

GLUCOCORTICOSTEROIDS DURATION OF ACTION hydrocortisone long dexamethasone medium prednisolone short

26. SPECIFY MULTIPLE CORRECT ANSWER Beta-adrenergic agonist (long-acting)

[] ketotifen

[] salmeterol

[] formoterol

[] omalizumab

[] tiotropium bromide

27. SPECIFY THE APPROPRIATE MODE OF ACTION DRUGS cholesterol absorption inhibition lovastatin inhibition of HMG-CoA reduc- ezetimibe tase modification utilization of free nicotinic acid fatty acids

28. SPECIFY THE APPROPRIATE GROUP OF DRUGS DRUGS fibrates pravastatin statins colesevelam anion exchange resins gemfibrozil

29. PROVIDE YOUR ANSWER

CORRECTION FOR DYSLIPIDEMIA WITH NONALCOHOLIC FATTY LIVER DISEASE DESIGNATE:

() tiazolididions

() statins

() gepatoprotectors

() antioxidants

() vitamin complexes

30. SPECIFY THE APPROPRIATE CLINICAL CONDITION CHOICE OF THERAPEUTIC FORM exacerbation of chronic pancrea- tablets enzyme titis pain syndrome exocrine insufficiency encapsulated enzyme