www.biovision.com Toll Free: 800-891-9699 (US Only) Toll Free: 800-891-9699 F:T: 408-493-1801 408-493-1800 CA 95035 Blvd, Milipitas, 155 Milipitas S. used to identify biomarkerused to for identify (non-)response for adverse factors and risk reactions. drug be can development the novelKits potencyAssays for therapeutics; ELISA of and identification lead cal and ELISA for your Kits research needs. antibodies These used be for preclini as controls can of solid tumors and hematological malignancies. Several function. antibodies monoclonal have received FDA approval for treatment the of avariety plement-dependent (CDC), cytotoxicity -dependent (ADCC) cellular cytotoxicity regulation or of throughdirect receptor action ofinduction or blockade apoptosis; killing cell by immune-mediated com therapy.cancer Several mechanisms of killing tumor cell by antibodies (mAbs) summarized be can as: Human antibodies based IgG monoclonal (mAbs) for of therapeutics are fastest-growing the category (Mabthera®) (Human) ELISA Kit (VWR Cat. No. TBA) Cat. (Human) (Mabthera®) Rituximab (VWR ELISA Kit Anti-Carcinoembryonic using BioSimTM (C) for No. 76005-706). Cat. curve Standard (Arcitumomab), (VWR IgG1 Human Antibody staining Immunohistochemical and Immunofluorescent (A)(B) Legend: Figure A Featured Antibodies: Biosimilar Antibodies and ELISA Kits momab), IgG1 Human Antibody (Arcitu antigen Anti-Carcinoembryonic Antibody IgG4 Human (Volociximab), 1Integrin 5beta Anti-alpha Antibody (Bevacizumab),Anti-VEGF humanized Product Name Rat Pancreas Rat Human Endometrial Cancer B - Specificity CEA-Scan BioVision Avastin - is pleased to offer research-grade biosimilar research-grade to pleased is offer C Cat. No. Cat. A1096 A1045 A1092 Specificity IgG4 IgG1 IgG1 Size 200 µg 200 µg 200 100 µg 100 - - Product Name Specificity Cat. No. Specificity Size Anti-CD11a (), Human IgG1 Raptiva A1089 IgG1 200 µg Antibody Anti-CD20 (Rituximab), Chimeric Antibody Mabthera A1049 IgG1 100 µg Anti-CD4 (), Human IgG4 - A1091 IgG4 200 µg Antibody Anti-CD40L (Ruplizumab), Human IgG1 Antova A1094 IgG1 200 µg Antibody Anti-CD52 (Campath-1H), Human IgG1 Campath A1105 IgG1 200 µg Antibody Anti-EGFR (Cetuximab), Chimeric Antibody Erbitux A1047 IgG1 100 µg Anti-EGFR (Matuzumab), Human IgG1 - A1090 IgG1 200 µg Antibody Anti-EGFR (Panitumumab), humanized Vectibix A1050 IgG1 100 µg antibody Anti-HER2 (Trastuzumab), humanized Herceptin A1046 IgG1 100 µg Antibody Anti-IL-2R alpha (CD25) (), Hu- Simulect A1098 IgG1 200 µg man IgG1 Antibody Anti-IL-2R alpha (), Human Zenapax A1099 IgG1 200 µg IgG1 Antibody Anti-OX40L (), Human IgG1 Xolair A1088 IgG1 200 µg Antibody Anti-PD-1 (), Humanized Anti- Opdivo A1307 IgG1 100 µg body Anti-PD-1 (), Humanized Keytruda A1306 IgG1 100 µg Antibody Anti-PD-L1 (), Humanized Tecentriq A1305 IgG1 100 µg Antibody Anti-TNF alpha (Humicade), Human IgG4 Humicade A1093 IgG4 200 µg Antibody Anti-TNF alpha (), Human IgG1 Remicade A1097 IgG1 200 µg Antibody Anti-TNF-α (), humanized Humira A1048 IgG1 100 µg Antibody

ELISA Kits for Biosimilar Antibodies:

Product Name Specificity Cat. No. Specificity Size

BioSim™ Adalimumab ELISA Kit Humira E4372 Human 100 Assays

BioSim™ Bevacizumab ELISA Kit Avastin E4373 Human 100 Assays

BioSim™ Cetuximab ELISA Kit Erbitux E4379 Human 100 Assays

BioSim™ Denosumab ELISA Kit Prolia E4380 Human 100 Assays

BioSim™ ELISA Kit Enbrel E4374 Human 100 Assays

BioSim™ ELISA Kit Simponi E4377 Human 100 Assays www.biovision.com www.biovision.com

2 Product Name Specificity Cat. No. Specificity Size

BioSim™ Infliximab ELISA Kit Remicade E4375 Human 100 Assays

BioSim™ Infliximab ELISA Kit Remsima E4378 Human 100 Assays

BioSim™ ELISA Kit Yervoy E4384 Human 100 Assays

BioSim™ Nivolumab ELISA Kit Opdivo E4382 Human 100 Assays

BioSim™ ELISA Kit Xolair E4381 Human 100 Assays

BioSim™ Pembrolizumab ELISA Kit Keytruda E4383 Human 100 Assays

BioSim™ Rituximab ELISA Kit Mabthera E4371 Human 100 Assays

BioSim™ Trastuzumab ELISA Kit Herceptin E4376 Human 100 Assays

ELISA Kits for Anti-drug Antibodies:

Detection Product Name Cat. No. Specificity Size Method

BioSim™ anti-Adalimumab ELISA Kit Humira E4388 Human 100 Assays

BioSim™ anti-Bevacizumab ELISA Kit Avastin E4389 Human 100 Assays

BioSim™ anti-Cetuximab ELISA Kit Erbitux E4391 Human 100 Assays

BioSim™ anti-Denosumab ELISA Kit Prolia E4394 Human 100 Assays

BioSim™ anti-Etanercept ELISA Kit Enbrel E4392 Human 100 Assays

BioSim™ anti-Filgrastim ELISA Kit Neupogen E4399 Human 100 Assays

BioSim™ anti-Golimumab ELISA Kit Simponi E4393 Human 100 Assays

BioSim™ anti-Infliximab ELISA Kit Remicade E4387 Human 100 Assays

BioSim™ anti-Infliximab ELISA Kit Remsima E4390 Human 100 Assays

BioSim™ anti-Ipilimumab ELISA Kit Yervoy E4398 Human 100 Assays

BioSim™ anti-Nivolumab ELISA Kit Opdivo E4396 Human 100 Assays

BioSim™ anti-Omalizumab ELISA Kit Xolair E4395 Human 100 Assays

BioSim™ anti-Pembrolizumab ELISA Kit Keytruda E4397 Human 100 Assays

BioSim™ anti-Rituximab ELISA Kit Mabthera E4385 Human 100 Assays www.biovision.com BioSim™ anti-Trastuzumab ELISA Kit Herceptin E4386 Human 100 Assays Please visit www.biovision.com for a comprehensive overview on these products. 2 3