Spot on Biotechnology Business 2017/2018

Online Company Company Database Directory www.bio.nrw.de

BIO.NRW Merowingerplatz 1 40225 Düsseldorf, Germany Fon +49 211 385469-9200 Fax +49 211 385469-9220 [email protected] www.bio.nrw.de

Ministry of Economic Affairs, Innovation, Digitization and Energy of the State of North Rhine-Westphalia 40213 Düsseldorf www.wirtschaft.nrw

www.bio.nrw.de Spot on Biotechnology Business 2017/2018

From Mind to Market: Biotechnology Company Directory 2017/2018 North Rhine-Westphalia BIO.NRW

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Editorial

Dear Reader, The degree of efficiency is indicated by the latest OECD statistics on biotech patents. Biotechnology is one of the key technologies According to the survey, no other region in of our century, and North Rhine-Westphalia Europe surpasses North Rhine-Westphalia (NRW) is surely one of the main players when in terms of biotechnology related patents. it comes to developing this technology. In an More precisely, if you look at the list of the interstate comparison, NRW accounts for top ten applicants for European patents, the highest turnover generated by biotech you cannot help noticing that, in the field of companies (€1.64bn) in 2016, with a – quite biotechnology, three out of seven leading remarkable - annual growth of 8.6 per cent. players are based in NRW. North Rhine-Westphalia is home to one in The State Government strongly supports five German biotech companies. biotechnology as one of North Rhine-West- The biotechnology landscape in NRW phalia’s key industries. Conscious of the extends from a strong academic sector great potential of the digital revolution, we and highly renowned research institutes are therefore keen to create an innovation- to dynamic start-ups as well as small and friendly environment with as little red tape medium enterprises and global chemical as possible. This includes solid and efficient and pharmaceutical players. This potent infrastructure to benefit our industries as a mixture of different actors is one of North reliable economical partner in Germany, the Rhine-Westphalia’s key strengths and forms European Union and throughout the world. a network of local industrial sites which span the entire state. In the far west of NRW, the area surround- ing Aachen and Jülich, top level engineering institutions have established a close coop- This type of fundamental research is backed eration with the biotech industry, paving the by a strong pharmaceutical industry, speed- way for further advances in the life sciences. ing up the translation of academic findings The Rhine-Ruhr region, on the other hand, to industrial innovation. specialises in medical biotechnology: From The north-eastern corner of NRW is home Prof Dr Andreas Pinkwart the southern tip, around Rheinbach near to those at the leading edge of nanotech- Bonn down the river Rhine (Bonn, Cologne, nology, with a solid link to technological Minister of Economic Affairs, Innovation, Düsseldorf, Wuppertal) and across to Dort- applications. There are also some highly Digitalization and Energy of the State of mund at the eastern edge of the Ruhr, high- professional business incubators engaging North Rhine-Westphalia end research institutions are busy working in the transfer of specialised technologies on healthcare issues on a molecular level. right across the state.

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Greeting

Dear Reader, 2016, we have been the local host of the BIO-Europe, Europe’s biggest life science the biotech landscape in North Rhine- partnering event, in Cologne, that set up Westphalia (NRW) is in a constant process a new record in attendees and one-to one of growth and development: within in the meetings. We wish this year’s venue and last 10 years the total number of core bio- all attendees a successful networking, but tech companies in NRW more than doubled first of all we would like to welcome you, for from 53 in 2007 to 109 in 2016. In the same the 9th time in a row, at the BIO.NRW booth. time period numerous companies (e.g. I invite everybody to take advantage of our Adhesys, evoxx, DIREVO Biotech AG etc.) offerings and to engage with our state’s were subject of extensive merging & acqui- extensive and excellent biotech community, sition activities of global players, further that we also proudly represent on our just indicating the strength of NRW’s biotech recently completly remastered website. economy. Based on top academic institutions, numerous dynamics start-ups evolve in an environment of successful small and medium sized enterprises and world-wide active global players. The excellence of NRW biotechnological entrepreneurship is the successful development of the biotech also confirmed by facts: NRW is Germany’s start-up scene in NRW. These activities state with the highest turnover of biotech are supported by the region, e.g. through Dr. Bernward Garthoff companies and in no other German state our quarterly held “BIO.NRW Business An- Cluster BIO.NRW more employees are working in the biotech gels Zirkel” or “Business Angel Congress”, industry. taking place annually. A more illustrated Representative for Biotechnology of the Of course, this flourishing landscape did analysis of the key developmental facts German State of North Rhine-Westphalia not just happen to emerge but instead has of this leading European biotech region is been systematically generated within the provided in the 9th annual compendium of last decade. During this time, several state- NRW’s biotech business landscape “Spot of-the-art life science incubators were built on Biotech Business”. across NRW and investors were attracted The NRW biotech community is strongly to the life science hotspot “NRW”. Several connected locally but also internationally. institutional investors, as for example the Collaborations around the world are a key “High-Tech Gründerfonds”, Coparion, the strength. For example, a project on the “NRW.BANK” and others, are headquar- internationalisation of clusters and net- tered along the Rhine in Bonn, Cologne works supported by the federal ministry and Dusseldorf. In addition, a NRW based of education in research (BMBF) was very community of business angels specialized recently initiated by us together with our in life sciences is focussing on young bio- partner country China, aiming to start new tech companies and start-up projects. This B2B collaborations and intensify existing variety of different investors in combination ones. Of course, we welcome any local and with the corporate venture units of the international partners, who are seeking global enterprises strongly contribute to international partnering opportunities.

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Content

Editorial… ……………………………………………………………………………… 5 Company Directory 2017/2018 NRW

Greeting… ……………………………………………………………………………… 7 Non-specific Services… …………………………………………………… 28

Spot on Biotechnology Business… ………………………………… 11 Health and Medicine (including Animal Health)… …… 38

Biotech Landscape……………………………………………………………… 11 Industrial Biotechnology… ……………………………………………… 54

Stimuli for Start-Up‘s… ……………………………………………………… 11 Agrobiotechnology… ………………………………………………………… 60

Academic Biotech Research … ……………………………………… 13 Bioinformatics… ………………………………………………………………… 64

Biotech Business… …………………………………………………………… 15 Other Biotechnologically Active Companies……………… 66

Competence Clusters… …………………………………………………… 21 BIO.NRW Cluster Biotechnology North Rhine-Westphalia… ……………………………………………… 72 Industrial Biotechnology – CLIB2021 ……………………………… 21

Pharmaceutical Biotechnology – BIO.NRW.red … …… 23 Glossary …………………………………………………………………………… 74

From Mind to Market … …………………………………………………… 23 OECD Definition… ……………………………………………………………… 74

Organisation for Economic Co-operation and Biotechnology Map of North Rhine-Westphalia Development (OECD)… …………………………………………………… 74 Life Science Technology Parks and Incubators …… 24 Biotechnology company… ……………………………………………… 74

Biotechnology Map of North Rhine-Westphalia Dedicated biotechnology companies … ……………………… 74 Dedicated and other biotechnologically active companies ……………………………………………………………………… 26 Other biotechnologically active companies… …………… 74

Business Areas of Activity… …………………………………………… 74

Contact BIO.NRW……………………………………………………………… 74

Sources, Literature, Links… …………………………………………… 74

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Spot on Biotechnology Business

Biotech Landscape and chemical industry. Today the state has pace for the powerful pulse of the state’s life also developed into a life sciences hotspot: A science business. Meanwhile biotechnology North Rhine-Westphalia (NRW) is at the heart good reason for many top-level biotechnology is a maturing industry that expands rapidly. of Europe. 160 million people – almost a third companies and research institutes to have Its innovative technologies are applied to of the population of the European Union – live their headquarters here. Numerous suc - major industry branches serving health/ within a day’s drive of Düsseldorf, the state cessful start-up and spin-off companies are medicine, chemistry, food and environment. capital. 31.8 percent (i.e. EUR 180.9 billion in flourishing in NRW alongside a strong chemi- North Rhine-Westphalia has been developing 2015) of the direct foreign investment that cal and pharmaceutical industry that includes its biotechnology hotspot since 1995. More flows into Germany ends up in North Rhine- many well-known household names like than 20 years into the program, over 450 life Westphalia, where some 19.000 international Bayer, Evonik, Henkel, Grünenthal, Johnson science related companies are located here companies control their German and Europe- & Johnson or UCB. This business excellence – among them 129 biotechnology enterprises an operations from. NRW also is the number is endorsed by a dense network of outstand- including several global players (Figure 1). one trading state among Germany’s 16 fed- ing academic institutions, which focus on Major business areas covered are industrial, eral states.1 Summing up the in- and export biotechnology within a broad life sciences nano- and pharmaceutical biotechnology, of NRW the trading volume is EUR 389 billion. landscape. In addition, there is an equally rich and there is a focus on enabling technologies With around EUR 646 billion, NRW generates and robust funding environment to support and supporting services as well. Combining 21.7 % of the German GDP, putting it clearly and promote the industry, including venture the strong technical expertise evolving from at the top of all German federal states. It ac- capital providers and business development these areas has been the key driver for NRW counts for 4.5 percent of the European GDP organizations. as the state is pioneering the field of bio- (EU-28), making it one of the most important Biotechnology in NRW represents an active, economy in Germany. economic regions in Europe. Comparing NRW multi-centric network, which is setting the in an international ranking, it is ahead of sev- Stimuli for Start-Up‘s eral European countries such as Switzerland, Sweden, Poland, and Belgium.1 With 17.7 mil- Many of today’s successful young biotech lion inhabitants of which 8.1 million live in the 109 companies started as university spin-offs. Rhine-Ruhr area, that lists among the top 20 dedicated They took advantage of life science incuba- biotechnology metropolitan areas in the world – NRW is by companies tors and technology centers, whose existence far the most populous German state. Conse- can be pivotal for a start-up company. As quently, the state boasts the highest level of catalysts for regional infrastructure and eco- 20 other infrastructure within Germany including the biotechnologically nomic development, there are approximately country’s densest railway network and seven active companies 60 such centers and incubators in the im- international airports. Handling more than mediate vicinity of universities and basic re- 133 million tons of goods per year, Duisburg is search institutions in NRW. Mostly 20% of all the world’s largest inland port. With over 100 ~345 other life science German start-ups are based in NRW, the high- annual international trade fairs NRW has the related companies est rate of all German states2. They support largest trade fair venue of the world. Colognes technology transfer all the way from mind to “Koelnmesse” is the No.1 venue for more than market. At the time of the editorial deadline 25 different industries. Traditionally, North of this brochure, a total of 155 biotech and life Rhine-Westphalia has been Germany’s most Fig. 1: Life Science Company Landscape in science related companies were incubated by important location for the pharmaceutical North Rhine-Westphalia 25 of these technology centers.3 You will find

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12 BIO.NRW the respective locations of the centers and Fig. 2: Biotechnology is a strongly linked industry the number of biotech companies each of them hosts on the map on page 24. The ser- IDEA MARKET vices these start-up centers provide include renting of affordable laboratory and office Branch Product/Service space, mediating business contacts, consult- ing on funding opportunities, and advising on Energy Raw Materials/ Fuels either founding or relocating a firm. Business- plan competitions are offered as an additional (functionalized) Foods / Fertilizer / Crops / Agriculture chance for support. One technology park Plant Protection that deserves to find special mention here is Proteins / Peptides / Chemicals through Biotech BioCampus Cologne, one of the largest of its Chemical Industry Processes (Enzymes, MO) / Molecular Electronics type in Germany. It houses more than 23,000 square meters of office and laboratory space, Basic/fundamental / Pre-requisite for applied Basic Research including state of the art S1- and S2 labs, reserach and development and industrial production facilities on a site Drug Delivery / (Companion) Diagnostics / Healthcare / Pharma totaling more than 25 hectares. Company Medical Devices / Therapeutics founders, young entrepreneurs and scien- BIOTECHNOLOGY tists all profit from NRW’s highly-networked Facilities / Infrastructure Transport ⁄ Laboratory supply / Materials biotechnology scene.

Engineering Nanotechnology Engineering Laboratory Information Systems / Digital (Biomedical) - IT Academic Biotech Research Healthcare / Biological Computing / Databases

North Rhine-Westphalia is offering Ger - many’s most comprehensive network of aca- Leibniz Institutes (11; 6 with life science activ- found in Aachen, Bonn, Cologne, Düsseldorf, demic institutions consisting of internation- ity). One quarter of all German students are Münster, Bochum, Essen, Dortmund, Biele- ally renowned Universities and Universities taking advantage of this excellent environ- feld, and other cities in the state. In the area of Applied Sciences (71; 25 with life science ment for science and education and are pur- of biotechnology, specializations in cell biol- activity), Max Planck Institutes (13; 6 with suing their studies in NRW, remarkably one ogy, (bio-) medicine, biochemistry, genom- life science activity), Fraunhofer Institutes third of all STEM fields (Science, Technology, ics, proteomics, metabolomics, molecular (14; 5 with life science activity), Helmholtz Engineering and Mathematics) students are biology, systems and synthetic biology, Institutes (4; 4 with life science activity) and studying in NRW. University centers can be analytics/microsystems, bioinformatics and

Fig. 3: Key biotechnology facts; NRW and Germany Annual turnover Total R&D expenditure (Mio. EUR) Percentage of NRW NRW * Germany ** relative to Germany 800 Number of 4,418 24,770 17.8 4 employees 600 750 Turnover Mio 1,765 3,634 48.57 3.6 bn EUR 400 R&D expenditure 368 1,118 32.92 Mio 200 368 Biotechnology 128 623 20.71 active companies 48.57 % 51.43 % 0 * data according to BioDeutschland survey - NRW, ** data according to Ernst & Young GmbH - BioDeutschland survey - Germany NRW Rest of Germany NRW Rest of Germany

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Table 1: Temporal Development Key Figures for the Biotechnology Industry of North Rhine-Westphalia

109 dedicated biotechnology companies in 2016 (95 in 2015, 89 in 2014, 87 in 2013 )

2015 2016 2013 2014 2015 2016 (inputation) (inputation) Number of 3,680 (n=67) 3,758 (n=68 ) 3,983 (n=75 ) 4229 4,044 (n=46) 4418 employees* Turnover* EUR 1.27 bn (n=29) EUR 1.32 bn (n=25) EUR 1.51 bn (n=30) EUR 1.671 bn EUR 1.64 bn (n=28) EUR 1.765 bn R&D EUR 214 m (n=29) EUR 241 m (n=22) EUR 258 m (n=30) EUR 330 EUR 325 m (n=31) EUR 368 m expenditure* based on survey BIOCOM based on survey BioDeutschland

* Data based on survey data as indicated; n means number of companies giving indication process engineering are all on offer. For over basic research to final therapeutics the CIO is Cologne and Bonn as well as their University a decade, NRW has been the leading German currently being expanded for EUR 78 million. Hospitals plus the DZNE in Bonn, Cologne region in stem cell research and development Here, newest research progress is directly has been developed into a world-wide unique with Münster, Bonn and Cologne as hotspots. implemented into individual therapies for the competence center for ageing research. About In the field of plant genetics, the Max-Planck- patient’s well-being. one hour west of Cologne, Europe’s most Institute for Plant Breeding Research, Cologne innovative technology campus is currently deserves to be called the “cradle of plant Fig. 4: Size of Dedicated Biotechnology taking shape: covering 800.000 square me- biotechnology” in Germany as the first plant Companies (Number of Employees) ters, “Campus Melaten” of the RWTH Aachen transformation technologies were developed 2,87% University will house up to 11 technology here. It is now tightly interacting with the clusters, among them the “cluster biomedical newly founded Cluster of Excellence on Plant technology” and take up investments of EUR 1 Science (CEPLAS) that was founded in 2012 22,99% 22,41% billion. Cooperation of academia and industry – an EUR 32 million collaboration of several are creating synergy effects, e.g. the Forschun- universities and research institutes. Recent gszentrum Jülich has a long-standing coop- examples from Cologne emphasize the very eration with Siemens Medical Solutions to de- 24,14% dynamic development of NRW as a research 27,59% velop specialized instruments and techniques location: in May 2013 the all new research for brain research. BIO.NRW offers detailed facilities of CECAD (Cluster of Excellence- information about the academic life science Cellular Stress Responses in Aging-Associated landscape in NRW in its compendium “Spot Diseases) have been opened – an investment on Biotechnology Science”. This brochure is of EUR 85 million. In October 2013 the Max- below 10 10-49 50-99 composed in a similar manner like „Spot on Planck Society opened the new facility of 100-249 more than 250 Biotechnology Business“ and presents a total the Max-Planck Institute (MPI) for Biology of of 227 profiles of research institutes, centers Ageing in immediate vicinity to the new CECAD Additionally several world leading neurosci- and facilities in NRW. Its second issue has been building on the university campus. They offer ence institutes are located in close proximity. released in November 2016. cutting edge infrastructure and technology, Alone in 2013 more than EUR 193 million was incl. laboratory and office space for together invested into the neuroscience research facili- Biotech Business more than 700 international scientists, staff ties of the DZNE (German Center for Neuro- and students. Directly next to the MPI and degenerative Diseases) and the department Biotechnology became one of the most dy- CECAD the Center for Integrated Oncology of the university hospital Bonn. Along with namic business sectors over the last decades. (CIO) is located. To obtain a fast pipeline from the respective institutes of the Universities of Having such a complex industry it is hard to

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16 BIO.NRW find a simple value chain or to separate it from Fig. 5: Areas of activity The real economic impact of biotechnology other, more “static”, industries. Biotechnol- in NRW is therefore higher than these sta- ogy routinely uses other technologies, e.g. 5% tistics reveal. These companies listed here Nanotechnology and Engineering, to improve are at the innovative core of biotechnological 13% products. However, all colors of biotechnology 25% research and development. In contrast to the (green, red, white and blue) are linked to di- 4% business figures of the dedicated biotech verse other branches like the chemical indus- companies – as an example – the 2016 sales try (Figure 2). Looking on single services and 10% of Bayer AG and Evonik Industries AG alone, 24% products makes it obvious, that looking only on 7% both headquartered in NRW, are EUR 46.8 dedicated biotechnology companies reveals a billion and EUR 12.7 billion, respectively. Even minority of the impact biotechnology has on though only a part of their turnover can be the entire industry. For example a recent report assigned to NRW sites and not all products elucidated that the sum of the turnover of the Therapeutica Diagnostica are generated involving biotech processes, the European bioeconomy industry, is more than Drug Delivery Non-specific services key business sectors of both companies are EUR 2.1 trillion (!) and over 3.2 million people Bioinformatics Agrobiotechnology based on biotechnology. These two examples are employed in bio-based industries, under- Industrial biotechnology clearly demonstrate the enormous impact lying the importance of biotechnology on the whole economy.4 Fig. 6: Drug Development Pipeline by Indication Nevertheless, it is crucial to have uniform definition of the core biotech companies to Indication Number of Products monitor the development of the industry. This is especially true for start-ups, as these are the Neoplasms / cancer / oncology 32 innovative center of the community. For this purpose BIO Deutschland e.V., the branch as- Infectious and parasitic diseases 14 sociation of the German biotech industry and organizations, annually carries out a statistical Diseases of the nervous system 10 analysis of the German core biotech companies, allowing a more sophisticated view of the Skin and subcutaneous tissue 5 biotechnology landscape in Germany. It was carried out for the second time in 2017 will Symptoms, signs abnormal clinical and laboratory findings, not elsewhere classified 4 be continued in the next years, facilitating a more comprehensive comparison for all indi- Musculoskeletal system and connective tissue 3 vidual German states over the next years. The framework of the analysis is set by the OECD Diseases of the blood and blood-forming organs; immune disorders 2 definition of a dedicated biotech company and biotech associated companies (see page Mental and behavioural disorders 2 74). Based on this definition, 109 dedicated biotech companies were operating in NRW in Respiratory 2 2016. Their activities were complemented by 20 other companies with a biotechnological Endocrine, nutritional and metabolic diseases 1 commitment, mostly global players in the field of pharmaceuticals, chemicals or seed Digestive system 1 production. Since these companies are active in many diverse areas, their biotech related Other 1 business figures cannot be calculated exactly and are not included in the following statistics. Total 76

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18 BIO.NRW biotechnology has on the overall industry in position of NRW biotech. Together, NRW bio- GmbH (EUR 5 million), financing rounds of NRW and Germany. tech firms are placing the highest investments biotech companies increased to EUR 19.8 According to the latest OECD Biotechno- for R&D of innovative products – nationwide. million in 2015, mostly contributed by PAION logical Statistics report (which – except for Overall, the proportional expenditure, of AG with EUR 9.6 million. Of course, the to- limited “indicator” updates – still is the latest biotech companies based in NRW, for R&D tal amount of non-public investments into published detailed study in the field by the is with 20.9 % of the annual turnover more biotech companies in NRW was much higher OECD), North Rhine-Westphalia is Europe’s than 7 times higher than the mean of all other than these numbers reveal. In addition to the most innovative biotechnology region: It businesses in Germany (average of 2.87 %).9 big community of business angels based in generates more biotech PCT patent applica- The numbers reflect that biotechnology as a NRW, numerous (institutional) investors set tions than any other European region.5 The business sector is in the process of continu- up their business headquarter along the Rhine development of biotech innovations from NRW ous maturation: 45.7 % of all new founded life within the last years. These investors strongly has been constantly increasing: 4,121 biotech science companies are in fact biotech compa- foster young biotech companies. Investment patents have been filed within 4 years by NRW nies (in 1996 17.6 % of all life science companies activities into life science companies are also biotech companies and research facilities of were biotech companies, 27.4% in 2016). How- supported by the state, e.g. through our “BIO. which 4,118 have been published.6 Of the top ever, important factors that reduce the average NRW Business Angel Zirkel” and our annually ten patent applicants in Europe, seven are company age in the industry are new founda- “Business Angel Congress”. biotechnology active companies and three of tions and acquisitions of successful ventures With fourteen new dedicated and one new these, namely Bayer, Henkel and Evonik, are by global players as well as re-orientations other biotech-active companies in NRW in based in NRW.7 of companies. The employee structure reflects 2016 the state’s biotech scene continues The business figures of the 129 NRW bio- the mixture of companies based in NRW; to be one that’s growing at fastest pace in technological actives companies are set into it is divided into four major fractions with Germany. Over the past two years the state comparison with the 623 German biotech similar size and one small fraction; 22.4 % even counts 24 new companies leading to companies. In NRW more than 4,418 people (of of all companies have less than 10 employees, 109 dedicated and 20 other biotech active about 24,770 nationwide) – more than in any 46.6 % have less than 50 employees and 74.1 companies today (Table 2). The amount of other German federal state – were employed % less than 100 employees. 23 % of all com- biotech companies in North Rhine-Westphalia by dedicated biotech companies in 2016 and panies already reached a size of 100 – 250 that are active in multiple branches remained generated a turnover of approximately EUR employees and 2.9 % employ more than 250 constant with 27 percent (Figure 5). These 1.64 billion (EUR 1.76 based on imputation people (Figure 4). biotechnology companies with “nonspecific statistics) (Table 1). According to the national After financing rounds of EUR 17.7 million in business activities” include service providers company survey by Ernest & Young – that is 2015, mostly due to Neuway Pharma GmbH and suppliers for the industry. Germany’s two also based on BioDeutschland data – the NRW (EUR 5.9 million) and NEO New Oncology largest biotech companies with the highest biotechnology active companies generated about 48.6 % of the German biotech annual Fig. 7: Drug Development Pipeline by Phase turnover (EUR 3.63 billion expected for whole n/a Discovery Germany based on imputation statistics) 13 8 8 (Figure 3). Thus, the biotech industry in On the Market Lead optimization NRW is – to a large extend – responsible for 1 1 the economic impact of the German biotech Phase III business as a whole. EUR 368 million – a sig- 1 nificant annual increase by 11.5 % compared Phase II 3 to 2015 (EUR 330 million) – was reinvested Preclinical into R&D projects. 40 Phase I The development of this key business 9 figures underlines that the investments by the dedicated biotech companies in NRW are persistent and will advance the future market

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20 BIO.NRW numbers of employees in Germany7, QIAGEN Table 2: Number of dedicated biotech companies GmbH and Miltenyi Biotec GmbH used to be listed here. As Qiagen has developed into the NRW dedicated NRW biotech active Germany Business Year** field of medical applications, meanwhile the biotech companies companies / %* (active companies) company is accounted as a dedicated biotech 2007 53 496 company in the „health-medicine“sector in 2008 61 501 this survey. QIAGEN began as a spin-off from 2009 68 531 the University of Düsseldorf in 1984. Today, the company employs more than 4,700 ex- 2010 71 538 perts at 29 sites worldwide, and has become 2011 77 552 the leading provider of sample technology 2012 84 565 and a top player in molecular diagnostics especially in cancer detection and prevention. 2013 87 570 Through a number of strategic moves QIA- 2014 89 579 GEN today is one of the leading companies 2015 95 114 / 19.3 590 in biomarker discovery and development (i.e. 2016 109 129 / 20.7 623 companion diagnostics), which is the basis for the company’s redirection to the health * % of Germany total , ** 2007 - 2014 based on survey by BIOCOM; 2015 - 2016 base on survey by BioDeutschland business. Based on the invention of a mag- netic cell separation technology, Miltenyi Bio- sue” (5) increased by 1 (4 products in 2016). characterize the biotechnology landscape in tec was founded 1989 in Bergisch Gladbach The pipeline includes 13 therapeutics (13 North Rhine-Westphalia: Industrial Biotech- near Cologne. Since then, the company has in 2016, Figure 7) in the clinical phases I to nology and Pharmaceutical Biotechnology. expanded to 1,400 employees worldwide who III (17.1%).10 The majority of products (40 – produce and market over 14,000 products for 52.6 %) are preclinical drug candidates. The Industrial Biotechnology – CLIB2021 the global biomedical research community. overall number of products in development It is remarkable that this success has been pipeline slightly increased compared to 2016 CLIB2021 (Cluster Industrial Biotechnology solely achieved by generic growth. The ma- with 72 products (+ 5.5 %). 2021) is an international open innovation jority of dedicated NRW biotech companies With 14.8 percent (not accounting global cluster of large companies, SMEs, academic (47 %; 46 % in 2016) are active in the field of key players) – compared to 10.2 percent of institutes and universities, as well as other health and medicine developing new drugs companies in this sector across Germany stakeholders active in biotechnology and bio- or diagnostics within the pharmaceutical – industrial biotechnology remains a char- economy as a whole. The cluster comprises sector. At the time of the editorial deadline acteristic strength of NRW.11 The underlying over 100 members with a share of about 25 of this brochure the dedicated biotech com- classification refers to companies that de- % international members. The overall goal panies in the field of health and medicine velop enzymes, biomaterials or bioprocesses, of CLIB2021 is to network stakeholders along had developed a drug pipeline of in total 76 which can be applied to facilitate or enable and across value chains and to identify new products and product candidates, remain- large-scale production in the chemical in- opportunities for innovation, projects, and ing mostly constant over the last years. The dustry. The NRW-based companies Henkel business. Through this, the cluster develops detailed distribution by indication lists as and Evonik have been pioneering indus - cross-sectoral biotechnological solutions clear top one category “neoplasms/cancer/ trial biotechnology worldwide and are still for sustainable processes and products. oncology”, with 31 products in pipeline in 2017 its pacesetters. Pertinent project areas are identified by the (2016 - 32 products) (Figure 6). This is fol- CLIB2021 team in conjunction with members lowed by “infectious and parasitic diseases” Competence Clusters in an iterative process. CLIB2021 is a non-profit that increased from 10 (2016) to 14 products association, with its members shaping the in pipeline (2017). “Diseases of the nervous Besides the large number of biotech com- cluster’s interests and activities. The cluster system” (10) increased by 3 compared to panies, which have specialized in enabling coordinates several associated programmes 2016 with 7, and “skin and subcutaneous tis- technologies, two main fields of activity which cover different aspects of bioeconomy,

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22 BIO.NRW and invites members to become involved, red biotechnology.12 And as well in NRW the By the end of 2014 a new series of competi- bring in their own ideas and to generate a real key task of the most dedicated biotech com- tions were published by NRW’s state govern- benefit for their companies or institutions. panies (42% out of 109) is developing drugs ment, focussing on translational research in To this end, CLIB2021 organises a number of or diagnostics methods or find new ways for eight so-called “main markets” (NRW Leit- events throughout the year: the annual CLIB drug delivery.10 marktwettbewerbe), adopting a “two-rounds international conference (CIC), forum events, With a closer look to the overall German funding model”. Each round includes two calls topic-specific workshops, dedicated small medical biotechnology area, respectively for proposals. The results of the two calls in partnering meetings and visits to partners, to biopharmaceuticals, 14 out of 38 newly the first round in the main market “LifeS- sites or meetings in Germany and abroad. approved drugs were biopharmaceuticals in ciences” is published on www.leitmarktagen- In NRW, CLIB2021 is coordinating the regional 2016. 37% of the total is the highest percent- tur.nrw/leitmarktwettbewerbe/lifesciences. innovation network (RIN) “Stoffströme”, which age since the first biopharmaceutical was ap- 19 innovative research projects are funded seeks to improve the exploitation of biomass, proved. 12 And the sales of biopharmaceuticals by 38 Million euros.13 The start of the second wastes, and side streams in the region. This in Germany also increased by 12.4 % in 2016 round will be expected in the last quarter of action is funded by NRW’s Ministry of Culture relative to 2015 and reached a volume of about 2017. Members of the new successful consor- and Science (MKW). Another NRW-based pro- EUR 9.3 billion, which corresponds to 24.8% of tia will expand the sustainable BIO.NRW.red ject is dedicated to improve identification and the total pharmaceutical market in 2016. And network that connects major contributors production of high performance ingredients the biopharmaceutical pipeline is still filled, to medicine, healthcare, the pharmaceutical (HiPerIn) for markets like adhesives, cosmet- 636 compounds are in clinical development.12 industry and red biotechnology in the state. ics, or food and feed. This action is funded by For more than a century, NRW has been the Ministry of Economic Affairs, Innovation, the heartland of Germany’s pharmaceutical From Mind to Market Digitalization and Energy of the State of North industry and has an exceptional standard Rhine-Westphalia. Together with partners in biotechnological and medical education. This chapter provides an overview of 88 of in Germany, Flanders, and the Netherlands, This advantage, combined with the enormous the dedicated and 12 of the other biotechno- CLIB2021 is currently establishing the BioIn- market potential of biopharmaceuticals, gave logical-active companies from North Rhine- novation Growth mega-Cluster (BIG-Cluster). reason for BIO.NRW’s strategic initiative in the Westphalia as classified following the OECD This is supported by the German Federal field of red biotechnology called BIO.NRW.red. guidelines (page 74). For convenience, the Ministry of Education and Research (BMBF) Its starting point was the competition “Bio. companies are grouped in five areas according through a 5-year, 4 million Euro project, started NRW” in 2009, a call for projects announced to their main business: in 2016. It develops cross-border novel value by NRW’s Ministry of Innovation, Science and chains based on lignocellulose and the C1 Research (MIWF) to support the formation Non-specific Services gases CO and CO2 to produce chemicals. It also of consortia between academia and biotech Health and Medicine focuses on cross-border education concepts companies. The focal areas of the successful (including Animal Health) conveying the required competences for the projects were: development of drugs (bio- Industrial Biotechnology establishment of a circular economy. logicals and small molecules), generation of Agri/Agrobiotechnology new methods in diagnostics, establishment of Bioinformatics Pharmaceutical Biotechnology – biomarkers and introduction of new biophar- Other biotechnologically companies BIO.NRW.red maceutical technology platforms – especially based on cell cultures technology. For a more comprehensive directory that in- In the last decades, major milestones in Since 2009 the MIWF announced several cludes all life science and life science related medicine and healthcare have been achieved further calls for proposals in the field of red companies in NRW, please visit our company through pharmaceutical (“red”) biotechnol- biotechnology like “PerMed.NRW” (by the database at www.bio.nrw.de/en/company_da- ogy, namely in the development of drugs, end of 2010), focused on personalised medi- tabase. vaccines and diagnostics. In 2016 we had cine and “Translational Stem Cell Research” BIO.NRW invites you to discover North 365 medical biotechnology companies in (finished in June 2014). These activities Rhine-Westphalia‘s biotechnology commu- Germany. For many years most of the German continue to effectively boost the BIO.NRW. nity! biotech companies are active in the field of red initiative.

23 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Life Science Technology Parks and Incubators

The Netherlands

Q Gronau Weser

Q Bielefeld 6 1 6 Q Münster Q Ascheberg Q Rheda-Wiedenbrueck 2 Ems Rhine

Lippe

Q Bönen Dortmund 9 Essen 6 2 1 Q BochumQ Q Q 2 27 Essen 2 4 3 Q Ruhr Q Q Kempen Nettetal Witten 1 Q Witten Q Wuppertal Düsseldorf Q 12 Q Hilden Q Monheim 10 Q Langenfeld 3 Q Bergisch-Gladbach 7 3 24 Baesweiler 2 Q Köln Q Jülich 2 Herzogenrath 7 Q Q Troisdorf Q Rhine 2Q 9 Aachen Q Bonn2 Rheinbach Q Belgium Germany

24 BIO.NRW

Name City Companies* Homepage Zentrum für Bio-Medizintechnik (ZBMT) 9 1 Aachen www.agit.de TZA -Technologiezentrum am Europaplatz Aachen 2 2 INCA Technologiezentrum GmbH Ascheberg 2 www.inca-technologiezentrum.de

3 its-Internationales Technologie- und Service-Center Baesweiler Baesweiler 7 www.its-center.de Bergisch- 4 Technologiepark Bergisch-Gladbach 3 www.tbg.de Gladbach 5 Technologiezentrum Bielefeld Bielefeld 1 www.technologiezentrum-bielefeld.de

6 BMZ - BioMedizinZentrum Bochum Bochum 6 www.bmz-bochum.de

7 TZR - Technologiezentrum Ruhr Bochum 2 www.chip-tzr.de

8 Bio-Security Bönen 9 www.bio-security.de

9 BMZ - BioMedizinZentrum Dortmund Dortmund 27 www.bmz-do.de

10 Zentrum für Mikro- und Nanotechnologie Dortmund 2 www.mst-factory.de

11 LSC - Life Science Center Düsseldorf Düsseldorf 12 www.lsc-dus.de

12 ETEC - Essener Technologie- und Entwicklungs-Centrum GmbH Essen 1 www.etec.de 13 TPH - Technologie Park Herzogenrath Herzogenrath 7 www.tph.de

14 Technologiezentrum Jülich Jülich 2 www.tz-juelich.de

15 TZN - Technologie- und Gründerzentrum Niederrhein GmbH Kempen 3 wwwtzniederrhein.de

16 BioCampus Cologne Grundbesitz GmbH & Co. KG Köln 24 www.biocampuscologne.de

17 RTZ - Rechtsrheinisches Technologie- und Gründerzentrum Köln Köln 3 www.rtz.de

18 TechnologiePark Köln Köln 2 www.tpk.de

19 Creative Campus Monheim Monheim 10 www.cc-monheim.de www.technologiefoerderung- 20 Technologieförderung Münster GmbH Münster 6 muenster.de 21 CeNTech - Center for Nanotechnology Münster 6 www.centech.de

22 Gründer- und Technologiezentrum Rheinbach Rheinbach 2 www.wfeg-rheinbach.de

23 Forschungs- und Entwicklungs-Zentrum Witten GmbH Witten 4 www.fez.de ZBZ - Zahnmedizinisch Biowissenschaftliches Forschungs- und 24 Witten 2 www.zbz-witten.de Entwicklungszentrum Witten GmbH 25 Technologiezentrum Wuppertal W-tec GmbH Wuppertal 1 www.w-tec.de

Total: 25 155

* Life Science Companies 25 BIO.NRW

Biotechnology Map of North Rhine-Westphalia Dedicated and other biotechnologically active companies

Q The Netherlands Osnabrück Q Gronau Weser Q Greven Q Bad Salzuflen Q Münster Bielefeld Q Q Leopoldshöhe

Q Q Ascheberg Ems Rheda-Wiedenbrück

Rhine Bergkamen Q Bönen Q Lippe Q BottropQ Marl Gelsenkirchen Q Lippstadt Q Duisburg Q Q Q Dortmund Q Moers Q Bochum Essen Q Witten Ruhr Q Q Wuppertal Nettetal Düsseldorf Q Q Erkrath Neuss Q MonheimQ Hilden Mönchengladbach Q Q Q Langenfeld Dormagen Q Q Leverkusen Q Bergisch Gladbach Baesweiler Q Q Köln Q Q Jülich Herzogenrath Niederkassel Q Q Troisdorf Q Würselen Q St. Augustin Q Aachen Rhine Q Bonn

Belgium Germany

26 BIO.NRW

Dedicated companies1, 3 Dr. Bartling GmbH Bielefeld Morphoplant GmbH Bochum p. 48 A2M Pharma GmbH Monheim p. 39 multiBIND biotec GmbH Köln p. 58 Adhesys Medical GmbH Aachen p. 39 MykoMax GmbH Wuppertal p. 61 Affectis Pharmaceuticals AG Dortmund p. 39 Nanospot GmbH Münster Agrojector UG Köln NEO New Oncology GmbH Köln p. 48 AgroProtect GmbH Aachen p. 61 NeraCare GmbH Bönen AiCuris Anti-infective Cures GmbH Wuppertal p. 40 Neuway Pharma GmbH Bonn p. 49 Algiax Pharmaceuticals GmbH Erkrath p. 40 Nexigen GmbH Köln p. 49 aquila biolabs GmbH Baesweiler p. 29 NIPPON Genetics EUROPE GmbH Dueren arrows biomedical Deutschland GmbH Münster p. 40 Orthogen AG Düsseldorf ARTES Biotechnology GmbH Langenfeld p. 29 PAIA Biotech GmbH Köln p. 33 Autodisplay Biotech GmbH Düsseldorf p. 55 PAION AG Aachen p. 49 AxioGenesis AG Köln p. 41 PerkinElmer chemagen Technologie GmbH Baesweiler AyoxxA Biosystems GmbH Köln p. 29 PharmedArtis GmbH Aachen p. 50 Baliopharm GmbH Jülich p. 41 Phytowelt Green Technologies GmbH Nettetal p. 62 BBT Biotech GmbH Baesweiler p. 30 PL BioScience GmbH Aachen p. 34 beniag GmbH Jülich p. 30 PlasmidFactory GmbH & Co. KG Bielefeld p. 34 Bibitec GmbH Bielefeld p. 30 Protagen AG Dortmund p. 50 BioCheck GmbH Münster p. 41 Protagen Protein Services GmbH Dortmund p. 34 BioEcho UG Dormagen p. 42 Protectimmun GmbH Bochum p. 50 Biofrontera AG Leverkusen p. 42 QIAGEN GmbH Hilden p. 51 Bio-Mar GbR Düsseldorf Qithera GmbH Düsseldorf p. 51 Bioreact GmbH Troisdorf QLAYM Healthcare AG Düsseldorf BioSolveIT GmbH Sankt Augustin RheinCell Therapeutics GmbH Düsseldorf bitop AG Witten p. 55 Ridom GmbH Münster p. 65 BSV Bioscience GmbH Baesweiler p. 55 Saaten-Union Biotec GmbH Leopoldshöhe p. 62 Carpegen GmbH Münster p. 42 SanguiBioTech GmbH Witten p. 51 CellAct Pharma GmbH Dortmund p. 43 SAW Instruments GmbH Bonn CellSystems Biotechnologie Vertrieb GmbH Troisdorf p. 31 Scientific Biotech GmbH Köln CEVEC Pharmaceuticals GmbH Köln p. 43 Senzyme GmbH Troisdorf p. 58 Charles River Biopharmaceutical Services GmbH Erkrath p. 31 SeSaM-Biotech GmbH Aachen p. 58 Chembiotech Münster SIT - Soft Intelligent Therapeutics GmbH & Co. KG Dortmund p. 52 Chimera Biotec GmbH Dortmund p. 31 Sividon Diagnostics GmbH Köln p. 52 CIBUS Biotech GmbH Rheda-Wiedenbrück p. 32 Soluventis GmbH Bochum p. 52 Cilian AG Münster p. 43 Squarix GmbH Marl p. 35 CIRES Cell & Immune Dortmund p. 44 Syntab Therapeutics GmbH Würselen p. 53 Colbourne Pharmaceuticals GmbH Niederkassel p. 44 Sysmex Partec GmbH Münster | Görlitz p. 36 Creative Therapeutics GmbH Wuppertal Taconic Biosciences GmbH Köln p. 35 Cube Biotech GmbH Monheim p. 32 Transimmune AG Düsseldorf p. 53 Cygenia GmbH Aachen p. 44 Vivo Science GmbH Gronau p. 35 Cysal GmbH Münster p. 56 W42 Industrial Biotechnology GmbH Dortmund p. 59 Deutsche Saatveredelung AG Lippstadt p. 61 XanTec bioanalytics GmbH Düsseldorf p. 36 DIREVO Industrial Biotechnology GmbH Köln p. 56 Xell AG Bielefeld p. 36 Dynavax GmbH Düsseldorf evoxx technologies GmbH Monheim am Rhein p. 56 Other biotechnologically active companies2, 3 GEN-IAL GmbH Troisdorf p. 32 Genopath GbR Bonn BASF Personal Care and Nutrition GmbH Monheim IIT Biotech GmbH Bielefeld p. 65 Bayer AG Leverkusen p. 67 IMAX Discovery GmbH Dortmund p. 57 Cellex Gesellschaft für Zellgewinnung mbH Köln IMD Natural Solutions GmbH Dortmund p. 57 Evonik Degussa GmbH Essen ImmunoQure AG Düsseldorf p. 45 Evonik Industries AG Essen p. 67 InfanDx AG Köln p. 45 German Seed Alliance GmbH Köln p. 67 Informium AG Bergisch Gladbach Grünenthal GmbH Aachen p. 68 Isoloid GmbH Düsseldorf Henkel AG & Co. KGaA Düsseldorf p. 68 Lead Discovery Center GmbH Dortmund p. 45 Janssen-Cilag GmbH Neuss p. 68 Life & Brain GmbH Bonn p. 46 Kyowa Hakko Europe GmbH Düsseldorf Lonza Cologne GmbH Köln p. 33 Labopharm GmbH Bönen m2p-labs GmbH Baesweiler p. 57 Monsanto Agrar Deutschland GmbH Düsseldorf p. 69 Mares Ltd. Greven p. 46 Octapharma GmbH Langenfeld Matricel GmbH Herzogenrath p. 46 PHARMA WALDHOF GmbH Düsseldorf p. 69 Melema Pharma GmbH Köln p. 47 Succinity GmbH Düsseldorf Metavi Labs GmbH Bottrop p. 47 Syngenta Seeds GmbH Bad Salzuflen p. 69 miacom diagnostics GmbH Düsseldorf p. 47 Taros Chemicals GmbH & Co. KG Dortmund p. 70 Miltenyi Biotec GmbH Bergisch Gladbach p. 33 UCB Pharma GmbH Monheim p. 70 MLM Medical Labs GmbH Mönchengladbach p. 48 W. von Borries-Eckendorf GmbH & Co.KG Leopoldshöhe p. 70 MolekularBiologisches & Biochemisches Labor WeissBioTech GmbH Aschberg

1 List of dedicated biotechnology companies in the fiscal year 2017 1 2 OECD Definition page 74 3 including company sites in NRW that are not headquarters and are therefore not accounted as NRW-based companies in the annual study by “BIO Deutschland e.V.” 27 Non-specific Services

28 BIO.NRW non-specific services

System) is the first easy-to-use and fully Name aquila biolabs GmbH automated solution for the feeding of liq- uids into shake flasks. aquila biolabs is a German company providing innovative technologies for Address Arnold-Sommerfeld-Ring 2 shake flask and bioreactor fermentations. Postal Code/City 52499 Baesweiler Currently, the company offers two main products: CGQ and LIS. E-Mail [email protected] The Cell Growth Quantifier (CGQ) of- Internet www.aquila-biolabs.de fers automated and non-invasive biomass monitoring for various cultivations vessels Employees 10 such as shake flasks, serum bottles or Founded (year) 2014 glass bioreactors. LIS (Liquid Injection

recommendation, international registra- Name ARTES tion, EMA resp. FDA approval and GRAS Biotechnology GmbH certification are achieved in international collaborations. Expression platforms in- Address Elisabeth-Selbert-Str. 9 clude high yield yeasts and E. coli system Postal Code/City 40764 Langenfeld ARTES Biotechnology is an independent for efficient protein production. Our unique technology provider for the pharmaceuti- chimeric virus like particle (VLP) platform Fon +49 2173 27587-0 cal industry. Our business focus is on: METAVAX® is best suited for the develop- Fax +49 2173 27587-77 • vaccine development (VLP technology) ment of highly immunogenic vaccines in E-Mail [email protected] • process development of biopharma- human and animal health. Internet www.artes- ceuticals Our proprietary technologies ensure biotechnology.com • transfer of biosimilar processes freedom-to-operate and reliable, competi- Employees 22 Our technologies have resulted in innovative production of innovative targets mar- Founded (year) 2002 tive products marketed worldwide. WHO keted worldwide.

sis of multiple biomarkers in picogram Name AYOXXA Biosystems GmbH amounts of biological samples, allowing scientists to gain a maximum of high quality and reproducible insights. LUNARIS™ Address Nattermannallee 1 is fully scalable, with integrated, image- Postal Code/City 50829 Köln based quality control and transparent data AYOXXA Biosystems GmbH, based in processing and management, enabling Fon +49 221 222529-0 Cologne (Germany), is an international translational proteomics by addressing all Fax +49 221 222529-11 biotech company focused on the develop- the needs from basic to clinical research E-Mail [email protected] ment of its proprietary beads-on-a-chip and development. Internet www.ayoxxa.com technology for advanced protein analysis. AYOXXA is commercializing and ex - LUNARIS™. AYOXXA’s innovative multiplex panding a portfolio of detection kits cov- Employees 35 protein analysis platform is a fully integrat- ering ophthalmology, model-to-man and Founded (year) 2010 ed system designed for the parallel analy- immuno-oncology applications.

29 non-specific services BIO.NRW

rators, filtration systems, chromatography Name BBT Biotech GmbH and freeze dryers. On the basis of individual needs BBT Biotech GmbH also offers active Address Arnold-Sommerfeld-Ring 28 pharmaceutical ingredients like thrombo- Postal Code/City 52499 Baesweiler lytics (streptokinase, urokinase), fertility hormones (HCG, HMG, FSH), inhibitors Fon +49 2401 93310-0 BBT Biotech GmbH produces freeze-dried (Aprotinin, UTI) and others (Hyaluronidase, Fax +49 2401 93310-90 viable bacteria (probiotics like lactobacilli, Corticotrophin). E-Mail [email protected] bifidobacteria, yeasts) and metabolites not Internet www.bbt-biotech.de only in bulk but also in finished dosage forms to the pharmaceutical and health- Employees 30 food industriy. Founded (year) 1999 The fermenter capacity is up to 18.000 l. The downstream process is based on sepa-

gate with extremely high efficiency within Name beniag GmbH a few minutes. The unique transfer mecha- Address Huthmacherstrasse 20 nism allows manipulation of basically every Postal Code/City 52428 Jülich mammalian cell type and incorporates molecules directly into the cytosol, to guar- Fon +49 2461 616734 antee their immediate bioactivity. beniag +49 15780393499 beniag is a biotechnology company provid- focusses on production and development of Fax +49 2461 613907 ing unique and highly efficient solutions to customer oriented solutions with coopera- E-Mail [email protected] incorporate molecules into living cells and tion partners distributing the product line Internet www.beniag.com tissue in vitro. Based on membrane fusion “Fuse-It” worldwide. as a completely novel and patented trans- Employees < 10 fer mechanism, beniag liposomes offer an Founded (year) 2013 outstanding opportunity for customers to incorporate any type of molecule or aggre-

The entire production and purification Name BIBITEC GmbH process was successfully transferred for large-scale production leading to one of the first successful approvals of a biosimi- Address Universitätsstr. 25 BIBITEC Gesellschaft für Prozessentwick- lar in Europe. Postal Code/City 33615 Bielefeld lung mbH is specialized in the production In 2012 BIBITEC became part of and purification of proteins (e.g. hor - Nordmark Arzneimittel GmbH & Co. KG, Fon +49 521 106-6326 mones, mAbs) derived from mammalian Uetersen. In cooperation with Nordmark Fax +49 521 106-156233 cell cultures. and other validated partners BIBITEC pro- Internet www.bibitec.de One major achievement was an eryth- vides all activities from “gene to product” ropoietin (EPO) project that involved including cell line and process develop- Employees 12 the process development and the GMP- ment, GMP production, fill-and-finish and Founded (year) 2001 compliant production of an EPO biosimilar analytics. for use in phase III clinical trials.

30 BIO.NRW non-specific services

In 2010, we opened our new clean room Name CellSystems laboratories to meet the growing demands Biotechnologie for various 3D tissue models and services. Vertrieb GmbH Today, our portfolio comprises a wide range of products for cell biology research Address Langeler Ring 5 Since its formation CellSystems ® has and in vitro toxicology studies. Postal Code/City 53842 Troisdorf been a reliable partner for the life science community. CellSystems offers highly so- CellSystems is certified ISO 9001:2008. Fon +49 2241 25515-0 phisticated research products, including Fax +49 2241 25515-30 EU validated 3D in vitro skin models for E-Mail [email protected] research and toxicology assays that were Internet www.cellsystems.de developed and are produced at our onsite laboratories. Additionally, CellSystems Founded (year) 1992 offers a wide range of contract services.

global scientific network offering services Name Charles River that span the entire drug development Biopharmaceutical process. This allows us to provide our Services GmbH clients with more flexibility, experience and expertise to maximize resources and Address Max-Planck-Str. 15a optimize results based on their specific Postal Code/City 40699 Erkrath Charles River Biopharmaceutical Services program needs. GmbH is a leading contract service organi- Our services include: cell bank testing; Fon +49 211 9255-300 zation providing innovative and tailor-made analysis and clearance validation of con- Fax +49 211 9255-333 solutions for the quality control of biophar- taminants and impurities (residual DNA, E-Mail [email protected] maceuticals. host cell proteins and endotoxins); safety Internet www.criver.com We operate in full compliance with the studies for viruses and prions; charac - Employees 150 GMP/GLP standards. Our testing facilities terization of the final product, lot release Founded (year) 1993 in Erkrath and Köln, Germany are part of a testing; bioassays and stability studies.

ics, immunogenicity assessment, stability Name Chimera Biotec GmbH testing and biomaker quantification.

Address Emil-Figge-Str. 76a Postal Code/City 44227 Dortmund

Chimera Biotec is the leading provider of Fon +49 231 9742-840 ultra sensitive immunoassay development Fax +49 231 9742-844 and bioanalytical sample testing. Chimera E-Mail [email protected] provides customized services as well as Internet www.chimera-biotec.com target quantification based on in house assays. Chimera Biotec manufactures and Employees 20 markets ultra sensitive Immuno-assays Founded (year) 2000 for pharmacokinetics, pharmacodynam-

31 non-specific services BIO.NRW

industry. Fokus is analysis and product de- Name CIBUS Biotech GmbH velopment to identify e.g. animal species, species of plants, GVO, allergens. Address Amselweg 1 Postal Code/City 33378 Rheda-Wiedenbrück

Fon +49 5242 40556-0 Fax +49 5242 40556-270 E-Mail [email protected] Main activities of the CIBUS Biotech GmbH Internet www.cibus-biotech.de are the development and application of molecular analyses for the examination of Employees 7 processed food, feed, or their single com- Founded (year) 2001 ponents as well as other products from pharmacological, cosmetic, paint or paper

are manufactured in-house and sold to Name Cube Biotech GmbH scientific labs.

Address Alfred-Nobel-Str. 10 Postal Code/City 40789 Monheim Cube Biotech is a provider for protein expression, purification, and crystallization Fon +49 2173 99373-0 services with a focus on the pharmaceuti- Fax +49 2173 99373-99 cally relevant class of membrane proteins. E-Mail [email protected] Our services are complemented by Internet www.cube-biotech.com affinity tag-based and protein-specific chromatography matrices to offer a unique Employees 10 solution. Founded (year) 2012 Dedicated products for protein purification and membrane protein crystallization

genetically modified organism (GMO), al- Name GEN-IAL GmbH lergenes, plant and animal-identity. The laboratory is accredited (DIN EN ISO/IEC Address Heuserweg 13-15 17025) and official cross checking labora- Postal Code/City 53842 Troisdorf tory. We are member in the German official GEN-IAL GmbH is a specialist laboratory working group for method development Fon +49 2241 252-2980 for DNA based food and feed analyses. for GMO detection and quantification. Fax +49 2241 252-2989 GEN-IAL offers services and kits for GMO- We are listed laboratory for the American E-Mail [email protected] , allergene- and animal identity analyses NON-GMO- Project and the German VLOG Internet www.gen-ial.de as well as bacteria- and yeast detection (Verband Lebensmittel ohne Gentechnik and differentiation. We offer training in e.V.) for GMO-free labeling. Employees 10 PCR, contract research, several kits for New: Capturing of microorganism by Founded (year) 1998 DNA-extraction, PCR-kits for beer/wine polymer technology. spoilage bacteria and yeast, pathogenes,

32 BIO.NRW non-specific services

GmbH offers customized services, e.g. Name Lonza Cologne GmbH transfection services, proliferating cell services and cell modification services. Address Nattermannallee 1 The Lonza Cologne site develops, manu- Postal Code/City 50829 Köln factures and markets a comprehensive product portfolio of life-science research Fon +49 221 99199-190 tools around cultured cells, including non- viral gene transfer products for primary E-Mail [email protected] cells and hard-to-transfect cell lines. Internet www.lonza.com/research These products support scientists worldwide, enabling more efficient identi- Employees 108 fication of new targets for pharmaceuticals Founded (year) 1998 and therapies. Additionally Lonza Cologne

Over 30,000 scientific publications and Name Miltenyi Biotec GmbH the manufacture of more than 50,000 cell products for clinical use demonstrate the profound trust scientists and clinicians Address Friedrich-Ebert-Str. 68 have in MACS® Technology. Miltenyi Biotec Postal Code/City 51429 Bergisch Gladbach has been at the forefront of immunology, Miltenyi Biotec develops products and ser- stem cell biology, cancer research, and Fon +49 2204 8306-0 vices that advance biomedical research and neuroscience, as well as the clinical ar- Fax +49 2204 85197 cell therapy. Our technologies inspire scien- eas of hematology, graft engineering, and E-Mail [email protected] tists in basic and translational research, and apheresis, for over 25 years. More than Internet www.miltenyibiotec.com support clinical applications. Our integrated 2,000 employees in 28 countries are pas- www.miltenyi.tv solutions enable sample preparation, cell sionate about our cell and gene therapy Employees 2,000 separation, cell sorting, flow cytometry, cell solutions. Founded (year) 1989 culture, and molecular analysis.

assays are amenable to automation and run Name PAIA Biotech GmbH on standard plate readers or fluorescence microscopes. PAIA Biotech focuses on products for screening applications with Address Gottfried Hagen Str. 60-62 limited sample volume and high throughput Postal Code/City 51105 Köln requirements, e.g. in early cell line development. Fon +49 221 1686 2380 PAIA Biotech GmbH offers assays for the In addition to off-the-shelf products for rapid quantification of antibodies and IgG and IgG fragments PAIA Biotech GmbH E-Mail [email protected] proteins based on its proprietary assay also offers custom assay development. Internet www.paiabio.com technology. It features bead-based im - PAIA Biotech GmbH was founded in 2014 munoassays with fluorescence detection and is based at the RTZ in Cologne. Employees 6 in specially designed 384-well microplates Founded (year) 2014 which drastically simplify the workflow. The

33 non-specific services BIO.NRW

tion of basic research into cell therapy. Name PL BioScience GmbH PL BioScience has a broad expertise con- cerning human platelet lysate as a better BioScience alternative to fetal bovine serum. Address Dennewartstraße 25-27 WE DELIVER CELL SOLUTIONS PL BioScience offers diverse platelet Postal Code/City 52068 Aachen lysates and platelet lysate derived products, e.g. a patent-protected 3D cell culture Fon +49 241 95719-100 system. Fax +49 241 95719-109 PL BioScience is a young, ambitious and E-Mail [email protected] dynamic life science startup offering a Internet www.pl-bioscience.com portfolio of novel products and innovative technologies for human cell expansion in Founded (year) 2015 research and clinical applications. The company aims to accelerate the transla-

Germany. The company offers the pro - Name PlasmidFactory GmbH & Co. KG duction of plasmid and minicircle DNA in several quality grades: Research Grade and Address Meisenstr. 96 ccc Grade for research purposes and pre- Postal Code/City 33607 Bielefeld clinical applications, High Quality Grade as starting material for e.g. GMP production Fon +49 521 2997-350 of RNA and viral vectors and GMP Grade Fax +49 521 2997-355 PlasmidFactory is the leading contract for clinical applications. E-Mail [email protected] manufacturer of plasmid and minicircle Besides production of individual plas- Internet www.plasmidfactory.com DNA and the driving force in the develop- mids and minicircles, In Stock products ment of non-viral vectors for gene therapy that are deliverable immediately “off-the- Employees 16 and genetic vaccination. PlasmidFactory’s shelf”, e.g. reporter genes and AAV Helper Founded (year) 2000 research and development as well as the & Packaging vectors (pDG/ pDP family, complete service are located in Bielefeld, several serotypes) are also provided.

characterization incl. modification of new Name Protagen Protein Services GmbH biological entities as well as biosimilar products. Comprehensive proteome studies and Address Otto-Hahn-Straße 15 differential protein display techniques are Postal Code/City 44227 Dortmund offered in addition for example to support Fon +49 231 9742-6100 Protagen Protein Services (PPS) is a leading up and downstream process optimization of Fax +49 231 9742-6149 contract research organization with an large biotherapeutic production. PPS combines E-Mail contact@ProtagenProtein international customer base in the field of unique expertise in e.g. bioinformatics for Services.com Protein Analytics of biotherapeutics. With protein mass spectrometry with a long track Internet www.ProtagenProtein more than 17 years of experience in busi- record in protein chemistry and protein Services.com ness, PPS is able to offer a comprehensive, analytics. PPS provides you with the full Employees 70 GMP compliant spectrum of state of the range of services, from drug discovery and Founded (year) 1997 art analytical methods, ensure the highest development to release testing and regula- quality for the identification and structural tory compliance under ICH Q6B.

34 BIO.NRW non-specific services

Taconic operates three service laborato- Name Taconic Biosciences GmbH ries and six breeding facilities in the U.S. and Europe and maintains distributor relationships in Asia. Address Neurather Ring 1 Taconic Biosciences is a global provider Postal Code/City 51063 Köln of genetically engineered rodent models and services. Founded in 1952, Taconic Fon +49 221 96453-10 helps the biotechnology and pharma - Fax +49 221 96453-21 ceutical communities acquire, custom E-Mail [email protected] generate, breed, precondition, test, and Internet www.taconic.com distribute highly relevant research models worldwide. Employees 80 Specialists in Precision Research Mod- Founded (year) 1952 els and GEMs Design & Management,

nology. In addition, vivo Science can also Name vivo Science GmbH include immunological tests into standard toxicity studies for a medicinal product. vivo Science will provide GLP and GMP compli- Address Fabrikstr. 3 ant, validated study protocols and will assist Postal Code/City 48599 Gronau you in setting up a customized test program for your special requirements. Fon +49 2562 8170-0 vivo Science is a privately held CRO for pre- Fax +49 2562 8170-19 clinical studies focussing on the immune E-Mail [email protected] system. For years now, all regulatory agen- Internet www.vivoscience.de cies such as FDA or EMA very much enforce the testing of immunotoxicity (ICH-S8) and Employees 20 immunogenicity (ICH-S6) of new drug can- Founded (year) 2001 didates, especially if derived from biotech-

compounds for drug discovery industry and Name Squarix GmbH reagents for life science applications com- biotechnology prising antibodies, metabolic intermediates, fluorescent dyes & probes and different af- Address Elbestr. 10 finity matrices for proteins and cells. Postal Code/City 45768 Marl Moreover, Squarix is a custom producer of polyclonal and monoclonal antibodies Fon +49 2365 915-278 Squarix GmbH is a privately-held primary for biomedical research and offers all type Fax +49 2365 915-254 manufacturer of high purity Discovery of immunoanalytical services in the field of E-Mail [email protected] Chemicals and Immunoreagents. Since antibody technology. Internet www.squarix.de 1992, Squarix produces a broad product line of compounds that include innovative Employees 8 building blocks, reactive intermediates, Founded (year) 1992 natural products and derivatives, screening

35 non-specific services BIO.NRW

immunology, cell biology, microbiology, Name Sysmex Partec GmbH – Branch Office Münster biotechnology, agrosciences, plant breed- (Headquarter: Am Flugplatz ing, aquaculture and in pharmaceutical, 13, 02828 Görlitz) food and beverage industries. Address Otto-Hahn-Str. 32 Postal Code/City 48161 Münster Fon +49 3581 8746-0 Sysmex Partec is the collaboration between Fax +49 3581 8746-70 Partec, a worldwide leading pioneer, devel- E-Mail [email protected] oper and manufacturer of flow cytometry Internet www.sysmex-partec.com systems and Sysmex Corporation, a leading international supplier of in vitro diagnostic Employees 195 worldwide products. Founded (year) 1967 Sysmex Partec products are used in a wide range of applications in healthcare,

Name XanTec bioanalytics GmbH

Address Merowingerplatz 1a Postal Code/City 40225 Düsseldorf

Fon +49 211 9936-4744 XanTec bioanalytics specializes in biosen- Fax +49 211 9936-4746 sors and bio-nanocoatings. The company’s E-Mail [email protected] core competence are bioinert and bioac- Internet www.xantec.com tive nanocoatings for biomedical and bioanalytical applications. Products are SPR Employees 10 biosensor systems, SPR or other biosensor Founded (year) 1997 chips and coated slides for protein and DNA microarrays.

analytical tools for in-depth characteriza- Name Xell AG tion of biological systems and pharmaceutical proteins, guaranteeing optimal solutions Address Alte Verler Str. 1 for our customers’ bioprocesses. Postal Code/City 33689 Bielefeld Based on our proprietary technology, Xell has developed a wide range of customized Fon +49 521 96989-200 as well as commercial high-performance Fax +49 521 96989-201 Xell is an experienced partner for companies culture media, supplements and feeds for E-Mail [email protected] in the biotech and pharmaceutical industry specialized production cell lines includ- Internet www.xell.ag providing them with highly-efficient solu- ing CHO, hybridoma and HEK. Chemically tions in cell culture technology. With years of defined and free of animal components, Employees 26 industry experience, we bring our extensive our products meet or exceed all necessary Founded (year) 2009 expertise in high performance media and quality standards required for GMP manu- feed development, and apply our powerful facturing processes.

36 BIO.NRW non-specific services

37 BIO.NRW

Health and Medicine (including Animal Health)

38 BIO.NRW health and medicine

cept which will then be out-licensed or Name A2M Pharma GmbH partnered. The current lead projects focus on the treatment of Parkinson’s disease and are supported by the Michael J Fox Address Alfred-Nobel-Str.10 Foundation. A small molecular modulator Postal Code/City 40789 Monheim A2M Pharma is a spin-off from Schwarz of lipid rafts is in preclinical development Pharma with the aim of developing the most as an α-synuclein aggregation inhibitor Fon +32 484 26 55 06 promising projects of Schwarz Pharma’s for disease modifying treatment of Par- former R&D pipeline that was abandoned kinson’s Disease and potential for other E-Mail [email protected] for strategic reasons following its merger protein aggregation disorders. The second Internet www.a2m-pharma.com with UCB. lead project focusses on the treatment of This portfolio includes projects in neu- dyskinesias and involves a isorotigotine for Employees 3 rology and pain. A2M Pharma develops transdermal delivery. Founded (year) 2009 these projects until clinical proof of con-

as an adhesive, to seal areas of leakage Name Adhesys Medical GmbH or re-attach tissue, or as a hemostat, to stop bleeding. The company was founded in 2013 in Aachen, Germany. In February 2014, the founders closed a 7-digit seed Address Pauwelsstraße 17 Adhesys Medical develops fully synthetic, investment round with S-UBG, KfW and a Postal Code/City 52074 Aachen biodegradable surgical adhesives. Based group of private investors. In April 2014 the on a polyurethane platform technology team won the Rice Business Plan Compe- Fon +49 241 41250320 two products are currently under devel- tition in Houston, Texas and expanded to opment: The first has been designed for the United States after closing a further Internet www.adhesys-medical.com dermal use, to close a great variety of investment round of $2.7 Mio. with US topical wounds faster, more accurately investors. Employees 13 and with fewer complications. The Second Founded (year) 2013 is designed for use inside the body: either

its programs at late discovery/early de- Name Affectis Pharmaceuticals AG velopment stage. The company is located in Dortmund, Germany, and is looking for academic and industrial collaborations for testing its frontrunner compound. Address Otto-Hahn-Str. 15 Postal Code/City 44227 Dortmund

Fon +49 231 97427000 Affectis is a pharmaceutical company Fax +49 231 97427039 developing novel proprietary drugs for E-Mail [email protected] the treatment of neurodegenerative and Internet www.affectis.com neuroinflammatory diseases based on pioneering findings in the field of P2X7 Founded (year) 2006 receptors. Affectis will partner or license

39 health and medicine BIO.NRW

to MSD), designed to inhibit the viral ter- Name AiCuris Anti-infective Cures GmbH minase of the human cytomegalovirus, achieved positive results in the Phase 3 Address Friedrich-Ebert-Str. 475 study, and Pritelivir, a helicase-primase Postal Code/City 42117 Wuppertal inhibitor, being developed to treat herpes simplex virus type 1 and type 2 infections. Fon +49 202 31763-0 AiCuris is a pharmaceutical company Pritelivir has succesfully completed a Fax +49 202 31763-1177 focused on discovery, research and de- Phase 2 trial in genital herpes. Phase 2 E-Mail [email protected] velopment of novel, resistance-breaking development of a topical formulation for Internet www.aicuris.com antiviral and antibacterial agents for the the treatment of labial herpes is currently treatment of severe and potentially life- ongoing. Further programs are AIC499, a Employees 55 threatening infectious diseases. resistance-breaking gram-negative anti- Founded (year) 2006 The most advanced projects in the com- biotic and AIC649, an immune modulator pany’s pipeline are Letermovir (licensed for the treatment of hepatitis B.

male subjects exposed to AP-325) and shows Name Algiax Pharmaceuticals GmbH a good safety and tolerability profile in healthy volunteers after single and multiple dosing. Address Max-Planck-Str. 15a The human PK profile of AP-325 is compatible Postal Code/City 40699 Erkrath with once-a-day administration and fast onset Algiax Pharmaceuticals GmbH is a biotechnol- of action. A broad patent portfolio covering Fon +49 211 617851-15 ogy company that was established in April major commercial markets is solely owned by Fax +49 211 617851-50 2011. It is dedicated to the discovery and Algiax. The primary indication is neuropathic E-Mail [email protected] development of innovative products in the pain, the secondary indication is spinal cord Internet www.algiax.com field of nervous system disease with a strong injury for which Algiax has an orphan drug des- focus on neuropathic pain. The company’s ignation. Altogether, Algiax is well positioned Employees 6 lead compound AP-325 is currently in clinical to take advantage of the market opportunity Founded (year) 2011 development. The comprehensive Phase I not only in the field of neuropathic pain but program has been finalized (>100 male and fe- also in other unmet medical diseases.

microarrays(GenExpression, Array-CGH, Name arrows biomedical Deutschland GmbH ChIP on chip, DNA-Methylation-Microar- rays), PCR (RT-qPCR) and bioinformatics. In the area of medical diagnostics, the portfolio Address Heisenbergstraße 11 includes routine analysis (testing for all clini- Postal Code/City 48149 Münster cal relevant biomarkers and the complete Fon +49 251 534064-00 arrows biomedical Deutschland carries range of blood analysis), flow cytometry Fax +49 251 534064-01 out contract research and clinical routine (NAVIOS), HPLC analysis, diagnostic micro- E-Mail [email protected] analyses, and also pursues its own R&D arrays, detection of freely circulating tumor Internet www.arrows-biomedical.com projects. The firm’s areas of focus are pri- cells, and chemosensitive analysis. Further- marily in the fields of molecular oncology more, FISH analysis, general microscopy Employees 10 and neurodegenerative disease. Its port- with the Zeiss axio imager M 2 in combina- Founded (year) 2005 folio of molecular analytics includes RNA/ tion with the MetaSystemsSoftware and DNA. Services like RNA/DNA isolation, Pyro- and Sanger sequencing.

40 BIO.NRW health and medicine

and improve drug candidate selection, re- Name Axiogenesis AG duce time and thus increase drug development efficiency. The products encompass Address Nattermannallee 1 hiPSC-derived cardiac (Cor.4U®, vCor.4U Gebäude S20 & FibroCor.4U) and neural cells (Peri.4U, Postal Code/City 50829 Köln Dopa.4U, Astro.4U & CNS.4U). Products in Axiogenesis is the leading provider of com- development include iPSC-derived sensory, Fon +49 221 998818-0 mercial-grade human induced pluripotent cortical and motor neurons as well as ma- Fax +49 221 998818-10 stem cell derived cells, which enable drug tured cardiomyocytes. E-Mail [email protected] development. Validated assays for each As a result of our in-house assay capabil- Internet www.axiogenesis.com cell type have been developed for advanced ity, we can provide expert scientific support drug discovery, disease and tissue mod- in order to facilitate selection and quick Employees 40 eling, safety and toxicology. Our innovative implementation of validated assays and Founded (year) 2001 and proprietary cells and assays accelerate technologies.

ized anti-TNF-receptor antibody, currently in Name Baliopharm GmbH phase I clinical studies, has been proven in head to head comparative, preclinical studies to be more safe and more efficacious as Address Karl-Heinz-Beckurts-Str. 13 state of the art marketed products. Postal Code/City 52428 Jülich Baliopharm is a pharmaceutical company In addition, Baliopharm´s service arm is firstly offering services for the preclinical GLP/GMP certified for analytics needed in Fon +49 2461 6210-855 and clinical development of biopharmaceu- preclinical and clinical studies We perform Fax +49 2461 6216-687 tical compounds and secondly dedicated to all kind of serum analytics needed for the E-Mail [email protected] the development of new innovative biophar- development of biopharmaceutical com- Internet www.baliopharm.com maceutical compounds for the treatment of pounds. We also offer a wide set of cell inflammatory diseases such as rheumatoid based potency assays for new biological Employees 20 arthritis, Morbus Crohn and multiple sclero- as well as for biosimilar products. Founded (year) 2011 sis. Our lead product ATROSAB, a human-

member of Polycheck®. Quantitative evalu- Name BioCheck GmbH ation is performed by picture scanning and calculation by Biocheck Imaging Software. The assay prodedure can be worked Address Vorbergweg 41 Biocheck introduced Polycheck® Platform out manually or fully automated including Postal Code/City 48159 Münster Technology as a tool for medical differential matching with central Laboratory Informa- diagnosis. The multiparameter test device tion Systems (LIS). Fon +49 251 2150-868 enables a serological quantitative allergy Fax +49 251 2150-870 screening on the basis of solid phase Im- E-Mail [email protected] muno-Assay-Technology using monoclonal Internet www.biocheck.de antibody detection; colorcoded devices are presenting different allergen panels. Employees 18 For autoimmune diagnosis a quantitative Founded (year) 1999 screening for disease patterns is new family

41 health and medicine BIO.NRW

developed a revolutionary single-step Name BioEcho Life Sciences GmbH technology for accelerated and simplified DNA and RNA purification processes. We apply this technology in the development of Address Nattermannallee 1 more convenient Liquid Biopsy procedures Postal Code/City 50829 Köln (isolation of circulating nucleic acids), faster NGS workflows, Point-of-Care diagnostics Fon +49 0221 9988 97-0 applications, and selected customization E-Mail [email protected] Founded 2016 by a team of experts in projects. Internet www.bioecho.de genomic sample preparation (extraction & clean-up of nucleic acids) BioEcho Life Employees < 10 Sciences provides a new generation of Founded (year) 2016 kits and reagents for genomic research and molecular diagnostics. BioEcho has

marketed in Europe and now also approved in Name Biofrontera AG the U.S. in combination with the medical lamp Address Hemmelrather Weg 201 BF-RhodoLED® for the treatment of actinic Postal Code/City 51377 Leverkusen keratosis. Biofrontera is the first smaller Ger- man biotech company to obtain centralized Fon +49 214 87632-0 Biofrontera AG is a biopharmaceutical EU and U.S. approval for a medical device/ Fax +49 214 87632-90 company specializing on the development drug it has developed itself. Biofrontera also E-Mail [email protected] of drugs and medicinal cosmetics for the markets a dermatological range of cosmetics. Internet www.biofrontera.com treatment of skin diseases and the regenera- The Belixos® products contain combinations www.biofrontera-us.com tive care of damaged skin. Headquartered in of active herbal substances, relieve itching Leverkusen, Germany, Biofrontera is pub- and redness and are used for the regenerative Employees 130 licly listed on the Frankfurt Stock Exchange care of chronic skin conditions. The Belixos® Founded (year) 1997 (B8F). Biofrontera’s lead product Ameluz® Protect, a daily skincare for sun-damaged is a prescription drug initially approved and skin, complements this cosmetic line.

system that sets new standards in micro- Name Carpegen GmbH biological periodontal diagnostics. A main objective of Carpegen’s research program Address Mendelstr. 11 is to develop and out-license POC/PCR Postal Code/City 48149 Münster systems for diverse applications in medical and non-medical markets. Two joint Fon +49 251 980-2320 Carpegen is a provider of high quality mo- R&D projects related to the development Fax +49 251 980-2321 lecular diagnostics. The company focuses of innovative antibiotic resistance diag- E-Mail [email protected] on developing real-time PCR assays and nostics and water analytics are currently Internet www.carpegen.de point-of-care (POC) diagnostics for the being pursued with financial support of diagnosis of specific infections and the the state of North Rhine-Westphalia and Employees 10 detection of genetic biomarkers. Carpegen the German Federal Ministry for Economic Founded (year) 2001 has developed Carpegen ® Perio Diag- Affairs and Energy. nostics, a powerful real-time PCR based

42 BIO.NRW health and medicine

clinical Phase II study for the treatment Name CellAct Pharma GmbH of refractory biliary tract-, small-cell and non-small cell-lung cancers. European Medicines Agency has grant- Address Otto-Hahn-Str. 15 ed orphan drug designation to CAP7.1 for Postal Code/City 44227 Dortmund the treatment of refractory biliary tract cancers. The recent interim analysis of Fon +49 231 9742-6350 CellAct Pharma GmbH is a venture capital the ongoing phase II study in biliary tract Fax +49 231 9742-6355 backed company focused on the develop- cancer indication resulted in favor of E-Mail [email protected] ment of innovative therapeutics for the CAP7.1 and met the primary objective of Internet www.cellact.eu treatment of cancers with high unmet disease control including partial response need. and stable disease with tumor shrinkages. Employees 7 The small molecule prodrug targeting The program has been recently acquired Founded (year) 2007 Topoisomerase, CAP7.1, is currently in by MundiPharma.

to adherent cell culture systems. CAP-GT Name CEVEC suspension cell lines grow to high cell den- Pharmaceuticals GmbH sities and show a broad viral propagation spectrum. Address Gottfried-Hagen-Str. 60-62 CAP-Go enables the production of re- Postal Code/City 51105 Köln CEVEC is a biotechnology company spe- combinant proteins previously out of reach cialized in the production of biopharma- that are notoriously difficult to express in Fon +49 221 46020-800 ceuticals using unique human cell-based conventional cell lines such as CHO. The Fax +49 221 46020-801 production systems: technology is successfully applied for the E-Mail [email protected] For scalable viral vector production, production of blood coagulation factors, Internet www.cevec.com CEVEC has successfully developed the C1-Inhibitor, other plasma proteins and CAP-GT suspension cell-based platform, high molecular mass proteins like laminins. which enables better scale-up and com- Founded (year) 2003 petitive production costs when compared

Name Cilian AG

Address Johann-Krane-Weg 42 Postal Code/City 48149 Münster

Fon +49 251 6203-114 Fax +49 251 6203-116 Cilian AG is a biotechnology company de- E-Mail [email protected] veloping and marketing a novel expression Internet www.cilian.de system. The company uses a species of Ciliates, a eukaryotic single-cell organism, Employees 14 for the production of vaccines, monoclonal Founded (year) 2001 antibodies and therapeutic enzymes.

43 health and medicine BIO.NRW

CIRES has further great experience in the Name CIRES cell + immune research services GmbH preclinical and clinical development and testing of vaccines and adjuvants. Address BioMedizinZentrum Bochum Universitätsstrasse 136 Postal Code/City 44799 Bochum CIRES is experienced in all kinds of cell Fon +49 234 93696536 culture techniques, ranging from genera- Fax +49 234 93696538 tion of hybridomas, culture of mammalian E-Mail [email protected] cells in general and the culture of lines of Internet www.cires.de transgenic cells. This includes production by Bioreactor technology, purification and Employees 3 labeling of monoclonal antibodies and Founded (year) 2001 development of ELISA tests.

Name Colbourne Pharmaceuticals GmbH

Address Viktoriaweg 7 Postal Code/City 53859 Niederkassel Colbourne Pharmaceuticals develops and Fon +49 2208 770505 produces drugs for the treatment of inborn Fax +49 221 470-5092 errors in metabolism and offers diagnostic E-Mail gschwarz@colbourne- services for molybdenum cofactor defi- pharma.com ciency and sulphite oxidase deficiency. Colbourne Pharmaceuticals provides ser- Employees 6 vices to Alexion Pharmaceuticals Inc. in the Founded (year) 2008 development of cPMP for the treatment of molybdenum cofactor type A deficiency.

enchymal stromal cells. Furthermore, we Name Cygenia GmbH provide biomarkers with clinical relevance Address Franz-Wallraff Str. 158 to address biological aging, acute myeloid Postal Code/City 52078 Aachen leukemia, and aplastic anemia. We are experts in project design and Fon +49 241 53108060 focus on supportive customer advisory Fax +49 241 53108069 Cygenia is the first company to provide service to find the best suitable biomarker E-Mail [email protected] service on epigenetic biomarkers. Epi - for your project. Doing so, we address u.gerstenmaier@cygenia. genetics is a new area of research that particularly scientists in the clinical field. com holds great potential for cellular analysis. Internet www.cygenia.com We have established cell-culture spe - cific biomarkers to analyze replicative Founded (year) 2014 senescence, pluripotency, buccal cell composition, and for classification of mes-

44 BIO.NRW health and medicine

tibodies against key drug targets that are Name ImmunoQure AG involved in preventing a number of human diseases.

ImmunoQure AG is a young biotech Address Königsallee 90 company spearheading the research and Postal Code/City 40212 Düsseldorf development of human-derived antibodies (HD-MABs) for the treatment of human E-Mail [email protected] diseases. Internet www.immunoqure.com Through our unique access to rare patient populations, we are able to identify Founded (year) 2011 patients harboring naturally optimized an-

after delivery. No suitable diagnostic ex- Name InfanDx AG ists today. Thus, ca. half of cases are not treated. Still, up to 15 unnecessary treatments are applied to cure one patient. Address Balthasarstr. 18 InfanDx develops the first test to be Postal Code/City 50670 Köln Develops first diagnostic test to detect applied immediately after birth. The im- perinatal asphyxia (PA, oxygen deficit dur- munology like format uses a small blood Fon +49 221 3008 9783 ing birth) and related braindamage. sample only. Technology origin is metabo- Fax +49 221 2851975 PA is very prevalent in childbirth world- lomics research. E-Mail [email protected] wide with 0.5-4% of births affected. Typi- InfanDx seeks partnerships as. Internet www.infandx.com cal outcome brain damage results in e.g. – pharma-partnering, („companion cerebral palsy/spasticism, blindness etc. diagnostic“, therapy monitoring) Employees < 10 Therapy is available and reimbursed since – manufacturer of point-of-care device Founded (year) 2010 2010, but needs to be started within 6 h – marketing co-operations

ducted in close collaboration with world- Name Lead Discovery Center class academic researchers from LDC’s GmbH broad network including the Max Planck Society, Helmholtz Association and numer- Address Otto-Hahn-Str. 15 ous universities. The LDC team consists of Postal Code/City 44227 Dortmund experts with solid industry experience in Bridging the gap between academic dis- Project Management as well as Screening, Fon +49 231 9742-7002 coveries and pharmaceutical development. Cellular Biology, Pharmacology, Medicinal Fax +49 231 9742-7039 Active in the field of drug discovery, LDC Chemistry and Therapeutic Antibody En- E-Mail [email protected] transforms promising early stage projects gineering. Internet www.lead-discovery.de into marketable assets providing industry LDC has formed alliances with AstraZen- with high-quality leads and biologics with eca, Bayer, Boehringer Ingelheim, Daiichi Employees 70 proof-of-concept in animals. These small Sankyo, Johnson & Johnson, Merck, Quri- Founded (year) 2008 molecule drug discovery projects are con- ent, Roche and SOTIO.

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Products and services include genome and Name Life & Brain GmbH gene expression analysis, industry scale human stem cell-based models of neurologic Address Sigmund-Freud-Str. 25 diseases for compound development as well Postal Code/City 53127 Bonn as electrophysiology services to character- LIFE&BRAIN is a development-stage bio- ize small molecules in target engagement, Fon +49 228 6885-100 medical enterprise serving as commercial efficacy and potency in human and rodent Fax +49 228 6885-101 hub of the University of Bonn Medical models. E-Mail [email protected] Center. Integrating a unique set of expertise Internet www.lifeandbrain.com in Genomics, Transgenics, Cellomics and Neurocognition, we aim at delivering the Employees 40 next generation of products for disease Founded (year) 2002 modeling and prediction, compound development and tissue regeneration.

2) Technology Commercialization – we Name Mares Ltd. identify suitable technologies for industrial clients, facilitate interaction between researchers and client, manage projects Address Münsterstrasse 87 on milestones/budgets in biology and Postal Code/City 48268 Greven At Mares Ltd, we serve two needs: 1) We chemistry. provide services re biologics/Advanced We also identify/develop and commer- Fon +49 2571 9588 001 Therapies/Medical Devices including GMP cialize academic/proprietary technologies, Fax +49 2571 9588 003 audits, Qualified Person (QP) services, QA, e.g. in the biomedical sector with a suc- E-Mail [email protected] qualification, validation and related as well cessful track record for 20 years+ in the Internet www.maresltd.eu as process development, design/execution EU, near east, USA, India, Korea. of aseptic production facilities for biolog- We welcome requests from industry, Founded (year) 2007 ics, tissue engineered products, gene/cell academia and government agencies. therapeutics, vaccines.

engineering and regenerative medicine. Name Matricel GmbH The products serve different medical fields like ACI-Maix and Cartimaix for tissue engineering of articular cartilage and Address Kaiserstr. 100 other orthopedic applications and Remaix Postal Code/City 52134 Herzogenrath Matricel GmbH develops and produces as a dental membrane for guided bone innovative medical class III collagen im- regeneration. Fon +49 2407 5644-0 plants and biomatrices for applications in Matricel´s product Optimaix is dedicated E-Mail [email protected] medicine and biotechnology. for research in 3D cell culture. Matricel has Internet www.matricel.com Matricel´s proprietary technologies are a promising product pipeline in further the key to successfully produce biocom- medical fields like dermal and nerve regen- Employees 28 patible and biodegradable matrices in a eration with customized scaffolds. Founded (year) 2001 wide range of modifications suitable for the cultivation with human cells in tissue

46 BIO.NRW health and medicine

ME-503 is in phase II of clinical develop- Name MELEMA Pharma GmbH ment. Subcutaneous injection leads to a substantial interaction of DC cells with cancer-fighting T cells. ME-503 has Address Nattermannallee 1 demonstrated efficacy in several phases Postal Code/City 50829 Köln I, I/II, and II trials. In melanoma stage IV Is a private clinical stage company founded ME-503 could improve the overall survival Fon +49 221 2823 2520 in September 2013. While legally head- of the patients. In this phase II trial, a pa- Fax +49 221 2823 2522 quartered of the predominantly virtually tient cohort could be defined, where the E-Mail h.lentzen@melemapharma. company in Hamburg, the scientific base one-year survival rate was 62% and the com is in Cologne. median overall survival 14.6 months. We Internet www.melemapharma.de MELEMA is playing in one of the hottest are currently planning a larger controlled areas in oncology: Immunotherapy. Our phase II trial using a biomarker to predict Founded (year) 2013 most exciting development candidate clinical outcome.

Name MetaVì Labs GmbH

Address Eichenkamp 10 Postal Code/City 46244 Bottrop

MetaVì Labs offers an automated cellular Fon +49 2045 4133 708 anaylsis system for multiple assays, in Fax +49 2045 4133 707 which cell movement is analyzed over time, E-Mail [email protected] e.g. chemotaxis, wound healing, angiogen- Internet www.metavilabs.com esis and spheroid growth. Further costum- made solutions are created on demand. Founded (year) 2012

results in less than 30 minutes directly from Name miacom diagnostics GmbH patient samples without need of tedious sample preparation or DNA amplification. Address Merowingerplatz 1a In addition to the world´s only molecular Postal Code/City 40225 Düsseldorf Miacom Diagnostics is specialized in de- diagnostic (MDx) test that identifies all rel- veloping next-level in vitro diagnostic tests evant pneumonia-related bacteria directly Fon +49 211 3015-5795 for the identification of pathogens causing from sputum, miacom offers CE & FDA Fax +49 211 2989-143 acute systemic diseases. Miacom improves cleared multiplex test for sepsis. Our latest E-Mail info@miacom- critical patient care by providing rapid mo- innovation includes a fully automated rapid diagnostics.com lecular diagnostic tools designed for routine ID system that allows high-throughput MDx Internet www.miacom- use to promote more efficient antibiotic testing of several hundred samples per day. diagnostics.com therapies and help healthcare organiza- Since 2014 Fosun Diagnostics, the diagnos- Employees 10 tions reduce costs. Our proprietary Direct tic division of Shanghai Fosun Pharmaceuti- Founded (year) 2006 Multiplex Imaging (DMI) assays deliver cal, is investor by miacom.

47 health and medicine BIO.NRW

USA, we offer seamless central laboratory Name MLM Medical Labs GmbH services for European and North American clinical sites. Address Dohrweg 63 Our lab is on duty 365 days a year to en- Postal Code/City 41066 Mönchengladbach MLM Medical Labs is a Central Laboratory sure valid results with a quick turnaround dedicated exclusively to clinical trials. We time. Fon +49 2161 4642102 offer full laboratory services, including a Our lab services are complemented by Fax +49 2161 4642190 whole range of analytics: standard safety superior logistics and our own MLM As- E-Mail [email protected] profiles, such as blood counts, coagula- sembly Services™ for customized sampling Internet www.mlm-labs.com tion, urinalysis and clinical chemistry, and kits. analyses of biomarkers, drug compounds, Employees 48 metabolites and molecular diagnostic Founded (year) 1993 parameters. With our strategic partner Cenetron Central Laboratories in Austin,

production, protein chemistry, molecular Name Morphoplant GmbH and cell biology, isotope protein labeling/ monitoring and optical biosensor technol- Address Universitätsstr. 136 ogy are available to our experienced and Postal Code/City 44799 Bochum multidisciplinary R&D team. Morphoplant’s proprietary technologies provide our cus- Fon +49 234 7772870 tomers with ultrahydrophilic and osteophilic Fax +49 234 7772870-20 long-term storable metal implant surfaces E-Mail [email protected] Morphoplant GmbH is a bio-/ medtec and solutions for biocoating of a variety of Internet www.morphoplant.de company headquartered at the BioMedizin- implant materials with recombinant growth Zentrum in Bochum and focused on the inte- factors (bone/ vascular). Our outstanding Employees 14 gration of biotech functionalities into medical expertise in surface functionalization, protein Founded (year) 2002 devices. Laboratories equipped with state-of- adsorption, kinetics monitoring and animal the-art technology for recombinant protein testing is also available for contract research..

allows the pathology laboratories to per- Name NEO New Oncology GmbH form Hybrid capture NGS-based molecular diagnostics, thus facilitating them to obtain Address Gottfried-Hagen-Str. 20 reliable and clinically meaningful results Postal Code/City 51105 Köln from single clinical samples. NEO New Oncology GmbH is a molecular NEO New Oncology employs scientists in Fon +49 221 888 238-0 cancer diagnostics company enabling the field of cancer genomics, translational Fax +49 221 888 238-22 pathologists to identify individual tumor medicine, bioinformaticians and special- E-Mail [email protected] profiles and to analyze and interpret ists in diagnostic quality assurance. Since Internet www.newoncology.de therapy-relevant genomic changes. 2016, NEO New Oncology has been a wholly NEO New Oncology´s CE-IVD compliant owned subsidiary of Siemens Healthineers. Employees 45 technology platform NEOonsite combines Founded (year) 2012 reagents for sample preparation with a proprietary bioinformatics pipeline and

48 BIO.NRW health and medicine

partner its CNS Drug Delivery Technology Name NEUWAY Pharma GmbH for application to proprietary compounds of pharmaceutical companies to exploit its therapeutic use in the field of CNS Address Ludwig-Erhard-Allee 2 indications. Postal Code/City 53175 Bonn The company is backed with venture capital from renowned investors and a Fon +49 228 522798-0 strong board. Fax +49 228 522798-99 NEUWAY Pharma GmbH, Bonn, Germany, E-Mail [email protected] is focusing on the preclinical and clinical Internet www.neuway-pharma.com development of innovative therapeutics for treatment of severe orphan brain diseases Employees 16 based on its proprietary CNS Drug Delivery Founded (year) 2014 Platform. The company also intends to

cant challenges to conventional discovery Name Nexigen GmbH approaches. Targets include aberrantly activated intracellular disease pathways in so-called cancer stem cells, for which Address Nattermannallee 1 currently no treatment alternatives exist, Postal Code/City 50829 Köln but which are main drivers of tumor recur- Nexigen GmbH leverages its extensive R&D rence and spread. Fon +49 221 337772-00 experience in peptide therapeutics for the Nexigen was founded in 2007 and is Fax +49 221 337772-29 efficient discovery and rational develop- headquartered at the BioCampus Cologne, E-Mail [email protected] ment of peptide medicines (“NexiTides”) Germany. Internet www.nexigen.de with qualified cellular mechanisms of action. Employees 23 Nexigen’s technologies give access to Founded (year) 2007 high value drug targets which pose signifi-

esthetic drug candidate which is in the final Name Paion AG stage of clinical development for use in pro- cedural sedation in the U.S. Currently, PAION is mainly focusing its business and financial Address Martinstr. 10-12 resources on successfully completing its on- Postal Code/City 52062 Aachen going clinical development program in pro- PAION AG is a publicly listed specialty phar- cedural sedation. Outside the U.S., PAION Fon +49 241 4453-152 maceutical company developing and aiming has so far focused on the development of Fax +49 241 4453-523 to commercialize innovative drugs to be remimazolam in the indication general an- E-Mail [email protected] used in out-patient and hospital basedseda- esthesia. PAION is headquartered in Aachen Internet www.paion.com tion, anesthesia and critical care services. (Germany) with a further site in Cambridge PAION’s lead compound is remimazolam, (United Kingdom). PAION’s vision is to Employees 31 an intravenous, ultra-short-acting and become an acknowledged “PAIONeer” in Founded (year) 2000 controllable benzodiazepine sedative/an- sedation and anesthesia.

49 health and medicine BIO.NRW

RNases or kinases. Since the binder can be Name Pharmedartis GmbH almost anything making it truly scalable. Human payloads should have much less Address Forckenbeckstr. 6 side-effects. We look for partner interested Postal Code/City 52074 Aachen in out-licensing opportunities for these first-in-class products. We develop CFPs to Fon +49 241 6085132-60 treat cancer, inflammation, auto-immune Fax +49 241 6085132-66 and skin diseases. 6 products are in preclini- E-Mail [email protected] Pharmedartis (PMA) develops next genera- cal testing. CFPs for clinical testing can be Internet www.pharmedartis.de tion targeted therapies. This platform tech- produced in Aachen in proprietary system at nology of Human Cytolytic Fusion Proteins a state-of-the-art GMP facility of Fraunhofer Employees 5 (HCFP) has several advantages over well- Society, of which PMA is a spin-off. As a one- Founded (year) 2007 received ADCs. A binder is recombinantly stop-shop we provide full service from gene fused to a payload. This can be proteases, to biopharmaceutical product.

novel biomarkers using its proprietary Name Protagen AG immuno-profiling platform (SeroTag®), and stratification arrays based on biomarker panels (NavigAID) to screen patient serum Address Otto-Hahn-Str. 15 We specialize in Pharma development specimens. Postal Code/City 44227 Dortmund services and novel companion diagnos- We enable: Better disease activity as- tics, in the field of immuno-oncology and sessment, Improved response prediction, Fon +49 231 9742-6301 autoimmune disease. Via co-development Patient monitoring and Early detection of E-Mail [email protected] projects with Pharma and Biotech compa- immune-related adverse events (irAEs). Internet www.protagen.com nies, Protagen enables effective, targeted To find out how Protagen can support immuno-therapeutic development for your therapeutic development project to Employees 17 improved patient care. enable better response prediction, patient Founded (year) 1997 Protagen is at the forefront of im - monitoring and early detection of adverse muno-profiling and the discovery of events contact us now.

tion of natural substances and bacteria Name Protectimmun GmbH with immunomodulatory properties from particular farm environments which are selectively transferred into pharmaceuti- Address Universitätsstr. 136 cal applications. Promising candidates Postal Code/City 44799 Bochum which were successfully tested in proof- of-concept animal models of asthma are Fon +49 234 9766 8275 currently in mid- to late-stage preclinical E-Mail [email protected] Protectimmun GmbH is a biopharma - development. Internet www.protectimmun.de ceutical R&D company focussed on new approaches in the prevention and therapy Employees < 10 of allergic and chronic inflammatory dis- Founded (year) 2007 eases. Our innovative concept for product development is based on the identifica-

50 BIO.NRW health and medicine

visible and ready for analysis. Bioinformat- Name QIAGEN GmbH ics software and knowledge bases interpret data to report relevant, actionable insights. Automation solutions tie these together Address Qiagen Str. 1 in seamless and cost-effective molecu- Postal Code/City 40724 Hilden lar testing workflows. QIAGEN provides these workflows to more than 500,000 Fon +49 2103 29-0 QIAGEN is the leading global provider of customers around the world in Molecular Fax +49 2103 29-22000 Sample to Insight solutions to transform Diagnostics (human healthcare), Applied E-Mail [email protected] biological materials into valuable molecu- Testing (forensics, veterinary testing and Internet www.qiagen.com lar insights. QIAGEN sample technologies food safety), Pharma (pharmaceutical and isolate and process DNA, RNA and proteins biotechnology companies) and Academia Employees > 4,600 worldwide from blood, tissue and other materials. As- (life sciences research). Further informa- Founded (year) 1984 say technologies make these biomolecules tion can be found at www.qiagen.com

survival of cancer patients. Qithera‘s R&D Name Qithera GmbH is based on new molecular findings from RWTH research and is implemented in close collaboration with the Hospital of RWTH Aachen University. By addressing internally validated target Address Columbusstr. 22 Qithera, Düsseldorf, Germany, is a “Busi- molecules that are known to abrogate ag- Postal Code/City 40549 Düsseldorf ness Angel Boost” that was founded by gressive characteristics of cancer (stem) Prof. Edgar Dahl (RWTH Aachen University) cells, Qithera is currently characterizing E-Mail [email protected] together with experienced biotech experts pharmacologically active compounds that Internet www.qithera.com of the BIO.NRW network. suppress tumor spreading. The first indica- The company is developing innovative tion of choice is a clinical important subset Employees < 5 drugs to suppress tumor progression of bladder cancer whose disease manage- Founded (year) 2012 and metastasis with the goal to improve ment has been stagnant for decades.

Name SanguiBioTech GmbH

Address Alfred-Herrhausen-Str. 44 Postal Code/City 58455 Witten

Fon +49 2302 915200 SanguiBioTech GmbH engages research Fax +49 2302 915191 and development of pharmaceutical, medi- E-Mail [email protected] cal and cosmetic products. Many of their Internet www.sangui.de technologies are patented and unique. Employees 6 Founded (year) 1995

51 health and medicine BIO.NRW

binding sites two inactive compounds to Name SIT - Soft Intelligent Therapeutics Biotech cancer cells, where they combine to an ac- GmbH tive product initiating apoptotic processes. Address Otto-Hahn-Str. 15 In parallel SIT develops novel intelligent Postal Code/City 44227 Dortmund and highly specific liposomal payloads on DNA basis for different diseases such e. g. Fon +49 231 9742 7252 Hepatitis B. Fax +49 231 9742 7251 Soft Intelligent Therapeutics (SIT) is a E-Mail [email protected] biotech company focused on personalized Internet www.sit-biotech.com cancer treatments combining maximum efficacy with minimum side effects. The Employees 6 first product candidate of its targeted gene Founded (year) 2010 delivery platform is designed to separately and selectively deliver via two different

first product being EndoPredict®, a breast Name Sividon Diagnostics GmbH cancer test identifying those patients who can be cured with an antihormonal Address Nattermannallee 1 treatment and therefore be spared an ag- Postal Code/City 50829 Köln gressive chemotherapy. It is worldwide the Sividon Diagnostics is a spin-off from first RNA-based diagnostic test for breast Fon +49 221 669561-00 Siemens Healthcare Diagnostics´ former cancer that can be carried out in any well- Fax +49 221 669561-99 research group in Köln. Its management equipped molecular pathology laboratory. E-Mail [email protected] team represents decades of professional ex- Also, Sividon is a member of the European Internet www.sividon.com perience in molecular diagnostics. Sividon study group “RESPONSIFY – Genomebased develops and markets innovative products biomarkers leading to validated molecular Employees 20 to improve the individualized selection diagnostic tests for response prediction in Founded (year) 2010 of therapies in oncology. The company breast cancer”. Since May 31, 2016 Sividon currently focusses on breast cancer, the is part of the Myriad Genetics group.

mune system contact, and reaches reliable Name Soluventis GmbH target organs including poorly vascularized tumor tissue. The targeting of metastases Address Im Lottental 36 is excellent. The frozen Nanocarrier has a Postal Code/City 44801 Bochum long shelf life in ampoules whereas in the organism it is completely eliminated within Fax +49 234 32 29125 two days. Fon +49 234 32 14191 The Soluventis-platform is based on the Soluventis has a portfolio of oncologic E-Mail soeren.schreiber@ most powerful drug delivery system, an siRNAs which significantly improve tumor soluventis.de entirely new type of Nanocarrier charac- reduction and elimination of metastases in Internet www.soluventis.de terized by incomparable high efficacy and xenograft models. In combination with the a very good safety profile. The Soluventis novel drug delivery system we offer a faster Founded (year) 2009 Nanocarrier shields the transported siRNA, and more effective development of clinical microRNA or peptides from blood and im- candidates for pharmaceutical companies.

52 BIO.NRW health and medicine

early out-licensing of product candidates Name Syntab Therapeutics GmbH after completion of the preclinical development. Syntab’s platform technology Address St.-Jobser-Straße 56 enables the chemical synthesis of highly Postal Code/City 52146 Würselen effective drugs against severe diseases such as cancer. The flexibility of the Fon +49 171 6558374 Syntab Therapeutics is committed to the technology is based on the application E-Mail info@syntab-therapeutics. exploration and development of innovative of diverse highly specific binders against com drugs against severe diseases such as can- specific cell surface proteins. Internet www.syntab-therapeutics. cer. Syntab’s synthetic antibodies exhibit Furthermore, the technology has the com all desirable properties of conventional potential to vary the number and specific antibodies while, at the same time, being properties of binders and effectors that Employees < 10 significantly smaller chemically accessible activate the immune system for each drug Founded (year) 2010 molecules. The company strives for the molecule.

ful immunological treatment used for many Name Transimmune AG years, mainly in cutaneous T cell lymphoma (CTCL), graft versus host disease (GVHD) and organ transplant rejection. Transimmune TRANSIMMUNE has created two core technologies; Transim- munization and Transtolerization. These in- Address Königsallee 90 Transimmune AG is developing novel immu- volve protocols for manipulating the immune Postal Code/City 40212 Düsseldorf notherapies based on its unique understand- system that have been reduced to practice ing of the physiologic processes underlying through our mouse-to-man development Fon +49 211 6413 6110 the activation of antigen presenting cells. platform, generating compelling preclinical Fax +49 211 8693 1614 This understanding derives from nearly 30 proof-of-concept data. These technologies E-Mail [email protected] years of research into the mechanism of ac- have the potential to significantly enhance Internet www.transimmune.com tion behind Extracorporeal Photopheresis current ECP practice as well as drive its ap- (ECP), arguably the first FDA-approved cellu- plication more broadly into numerous other Founded (year) 2012 lar immunotherapy. ECP is a highly success- indications.

53 BIO.NRW

Industrial Biotechnology

54 BIO.NRW industrial biotechnology

numerous benefits to biocatalysis, the func- Name Autodisplay Biotech GmbH tionalisation of solid surfaces and screening applications. With its custom-tailored products and Address Merowinger Platz 1a services, Autodisplay Biotech is an ideal Postal Code/City 40225 Düsseldorf partner for leading companies in the chemical, pharmaceutical and biotechnology Fon +49 211 2095 1378 industries. Fax +49 211 9945 9636 Autodisplay Biotech GmbH is a biotechnol- E-Mail [email protected] ogy company commercializing its propri- Internet www.autodisplay-biotech.com etary expression platform for the display of heterologous proteins or peptides on Employees 9 the surface of gram negative bacteria. This Founded (year) 2008 cell surface display technology provides

molecules that are formed by microorgan- Name bitop AG isms and plants. bitop AG produces such extremolytes in an industrial scale in its own facility in Witten according to its proprietary biotechnological production processes. Address Stockumer Str. 28 bitop AG has developed Ectoin®-containing Postal Code/City 58453 Witten medical devices for the symptomatic bitop AG focuses on the development, treatment of cough and cold, allergies, dry Fon +49 2302 914-400 manufacture and marketing of medical de- mucosa, inflammatory skin diseases and Fax +49 2302 914-4010 vices and high quality active ingredients for airway diseases. The marketing and sale E-Mail [email protected] cosmetics. The technological base of bitop of these medical devices is performed by Internet www.bitop.de AG’s business are substances from the class licensees from the pharmaceutical industry. of extremolytes, in particular the compound Currently, bitop’s medical devices are avail- Founded (year) 1993 Ectoin®. Extremolytes are natural protective able in more than 45 countries worldwide.

plied either as API or finished injectables, Name BSV Bioscience GmbH in co-operation with an also GMP approved German license manufacturer. Our main products are: Address Max-Planck-Strasse 12 – Human Chorionic Gonadotrophin (HCG), Postal Code/City 52499 Baesweiler – Human Menopausal Gonadotrophin BSV BioScience GmbH was founded in Oct. (HMG), Fon +49 2401 8047-10 2007 in Baesweiler, near the historical city – Follicle Stimulating Hormone (FSH), Fax +49 2401 8047-198 of Aachen. Since June 2010, the company – Urokinase (UK), Streptokinase and E-Mail [email protected] manufactures and markets biological phar- Ulinastatin (UTI). Internet www.bsvbio.de maceutical active ingredients for different BSV BioScience GmbH is focused on differ- therapeutic areas. ent R&D activities, continuously pursuing Employees 18 One of our key strengths is based on the improvements in the field of API´s and Founded (year) 2007 production of fertility hormones, being sup- finished dosage forms.

55 industrial biotechnology BIO.NRW

for these biomaterials to serve humans Name Cysal GmbH and animals. Cysal’s business strategy aims at out-licensing its technology plat- Address Mendelstraße 11 form to interested companies and/or Postal Code/City 48149 Münster offering its raw materials for incorpora- tion into consumer products for various Fon +49 251 980-2490 The innovative biotechnology company markets. Fax +49 251 980-2499 Cysal GmbH was founded as a spin-out of The main target markets are those for E-Mail [email protected] the University of Münster, Germany. energy food additives and sport nutrition, Internet www.cysal.de Cysal focuses on the production of novel cosmetics and skin care, dental hygiene, biomaterials in the area of biopolymers, clinical nutrition, immunomodulation, Employees 5 peptides, amino acids, and dipeptides on impotence and infertility, as well as in the Founded (year) 2012 an industrial scale at unprecedented low- area of animal feed production, especially cost, and also develops application fields for aquaculture.

supporting the needs of our customers Name Direvo Industrial Biotechnology GmbH and partners for sustainable and profitable processes which are urgently required by Address Nattermannallee 1 the developing BioEconomy. Postal Code/City 50829 Köln At Direvo, we focus on the emerging biomass Fon +49 221 47448-0 conversion industry. We are developing Fax +49 221 47448-111 and marketing biology-based products and E-Mail [email protected] processes utilizing safe and sustainable re- Internet www.direvo.com sources for a world still dominated by fossil raw materials. Our powerful scientific tools Employees 30 unleash the full value of biomass in current Founded (year) 2008 and novel industrial processes. Direvo is committed to deliver the best technologies

pharma industries is offered. Product Name evoxx technologies GmbH development is based on the proprietary technology platform covering the whole Address Alfred-Nobel-Str. 10 value chain from early enzyme and pro- Postal Code/City 40789 Monheim am Rhein cess development to industrial scale pro- evoxx technologies GmbH, a German duction and product deregulation. Fon +49 2173 4099-40 Industrial Biotechnology Company, is evoxx industrial partners and custom- Fax +49 2173 4099-440 focusing on the development and produc- ers benefit from the unique metagenomics E-Mail [email protected] tion of industrial enzymes. As European libraries, the enzyme development skills Internet www.evoxx.com subsidiary of the global enzyme manu- and tech-transfer and production capa- facturer Advanced Enzymes Technologies bilities. evoxx is located on the Creative Employees 35 Ltd. a comprehensive product portfolio Campus in Monheim am Rhein and on Founded (year) 2006 of enzymatic solutions for human nutri- the Biotech Campus Hermannswerder in tion, animal nutrition, bio-processing and Potsdam.

56 BIO.NRW industrial biotechnology

natural product based novel taste modula- Name IMAX Discovery GmbH tors. IMAX discovery is a 50:50 joint venture company between Axxam SpA in Milano, Italy, and IMD Natural Solutions GmbH in Dortmund, Germany. Address Otto-Hahn-Str. 15 Postal Code/City 44227 Dortmund IMAX Discovery is a research driven company, creating new product innovation through the Fon +49 231 9742-6440 generation and development of novel and Fax +49 231 9742-7401 natural flavour compounds for the food and E-Mail [email protected] beverage industry. Using our strong technol- Internet www.imaxdiscovery.com ogy platforms and expertise around taste receptors and natural products IMAX Discovery Founded (year) 2010 generates proprietary product pipelines of

development: AM-1 represents a new Name IMD Natural Solutions (patent pending) all natural antimicrobial GmbH preserving agent well suited to support product specifications for food, beverage Address Otto-Hahn-Str. 15 and personal care applications. AX-1 is Postal Code/City 44227 Dortmund targeting oil preservation via its strong Fon +49 231 9742-7400 IMD Natural Solutions (“INS”) aims to antioxidant profile. INS follows a dual busi- Fax +49 231 9742-7401 develop and commercialize groundbreak- ness model; besides the development of E-Mail info@imd-natural- ing ingredients – with a special focus on preserving agents INS provides Natural solutions.com preserving and anti-microbial agents – de- Product Service as one-stop service part- Internet www.imd-natural- rived from “all” natural sources. The main ner for all needs associated with Natural solutions.com target markets are in the Food & Beverage Product research, development, produc- Employees 10 as well as the Personal Care industries. tion or supply. Founded (year) 2012 Two product candidates are in advanced

tion platform. This technology empowers the Name m2p-labs GmbH biotechnology, chemical and pharmaceutical industry to increase the number and the information content of microbial experiments Address Arnold-Sommerfeld-Ring 2 (aerobic, microaerophilic and strict anaero- Postal Code/City 52499 Baesweiler bic). Experiments can be conducted with m2p-labs is a supplier of microbioreactors high efficiency and good quality at low costs. Fon +49 2401 805-330 for the Life-Science industry. The company Automated fermentation of the whole Fax +49 2401 805-333 focuses on microreaction and automated bioprocess is possible with the RoboLector®, E-Mail [email protected] solutions for screening and bioprocess de- a combination of the BioLector® system with Internet www.m2p-labs.com velopment. The product portfolio comprises a standard liquid handling robot. the BioLector®, the RoboLector® (automa- Employees 36 tion) and the disposable FlowerPlate® (MTP) m2p-labs | The Microbioreactor Company Founded (year) 2005 which provide an intelligent micro fermenta-

57 industrial biotechnology BIO.NRW

chemistry. bioDECONT® and bioCLEANTM Name multiBIND biotec GmbH are the only agents that in addition to the effective killing of microorganisms also Address Gottfried-Hagen-Str. 60-62 accomplish safe and complete decon - Postal Code/City 51105 Köln tamination of genetic material (DNA/RNA). Besides the highly efficient antimicrobial Fon +49 221 2780-211 action and decontamination properties they Fax +49 221 2780-213 multiBIND develops innovative decontami- are nontoxic for humans, non-corrosive and E-Mail [email protected] nation, disinfection and hygiene solutions for free of organic solvents or other hazardous Internet www.multibind.de molecular biology, healthcare and agricul- chemicals. multiBIND pursues a partnering ture. Core technologies are patent-pending strategy for new applications and markets Employees 3 systems to generate new disinfection and from suitable industry sectors. multiBIND Founded (year) 2005 decontamination agents for consumer offers and holds multiple licenses for prod- markets, hospitals, laboratories and agro- ucts and applications.

is on the development of intelligent mix- Name Senzyme GmbH tures of hydrolases, to be used in a most efficient degradation of plant material, Address Gierlichsstr. 6 e.g. in the course of methane production Postal Code/City 53840 Troisdorf from biomass.

Fon +49 2241 9715-2000 Fax +49 2241 9715-2499 E-Mail [email protected] Senzyme GmbH develops and produces Internet www.senzyme.de technical enzymes and other micro- biological products, all of which is well Employees 30 grounded in the company’s substantial Founded (year) 2000 experience in solid-state fermentation using filamentous fungi. Currently, the focus

modelling and simulations, SeSaM-Biotech Name SeSaM-Biotech GmbH tunes enzyme properties like activity, ther- mal resilience, protease resistance, solvent/ pH stability, and substrate/product inhibi- tion. The track record includes proteases, Address Forckenbeckstraße 50 monooxygenases, lipases, cellulases, amyl- Postal Code/City 52074 Aachen ases, phytases, esterases, glucose oxidases, pectinases, isomerases, laccases, and xyla- Fon +49 241 93856979 For companies using enzymes in their nases being applied in the biotechnological E-Mail [email protected] processes or as additives in their products, sectors pharma, chemistry, cosmetics, Internet www.sesam-biotech.com SeSaM-Biotech is the right partner to boost flavors, nutrients, feed, laundry, food/bever- the enzyme’s performance. With a combined ages, biofuel, textiles and paper. All protein Founded (year) 2008 approach of patented mutagenesis technolo- evolution projects are provided as a service gies and rational design by computational with attractive IP ownership agreements.

58 BIO.NRW industrial biotechnology

development – fermentation – DSP – Name W42 Industrial enzyme immobilisation. Since 2005 W42 Biotechnology GmbH GmbH has carried out many successful projects for industrial partners in Europe and P.R. China. Several improved strains Address Otto-Hahn-Straße 15 W42 GmbH is your partner for enzyme are running on industrial scale for produc- Postal Code/City 44227 Dortmund production and process development. tion of technical enzymes. We offer: High performance heterologous Furthermore W42 is working on rational Fon +49 231 9417 8991 protein production in Pichia sp. Wide strain improvement of microorganisms for E-Mail [email protected] range of different strains and promoters the optimisation of industrial production Internet www.w42biotechnology.de – best choice for your project. Methanol of natural compunds (e.g. antibiotics). dependent and Methanol independent Employees 3 high yield protein production. Complete Founded (year) 2005 processes are offered including: strain

59 BIO.NRW

Agrobiotechnology

60 BIO.NRW agrobiotechnology

from pathogens. We developed a patented Name AgroProtect GmbH platform based on antibody fusions which ensures plant protection from fungal and bacterial infections. This alternative approach for controlling plant pathogens and Address Forckenbeckstraße 6 parasites aims at minimising the costs for Postal Code/City 52074 Aachen cultivation of crops thereby reducing the toxic effects of pesticides and toxins for Fon +49 2451 914 8783 It is estimated that plant pathogens are re- human beings. Fax +49 2451 914 8784 sponsible of world-wide losses in the range AgroProtect GmbH licences its propri- E-Mail [email protected] of billions of Euros per year. Therefore, etary technology and offers the genera- Internet www.agroprotect.de there is a strong need to provide effective, tion of pathogen resistant plants as well broad range and environmentally friendly as access to novel resistant cultivars of Founded (year) 2010 approaches to ensure protection of plants several crops.

turf grasses, and different intercrop spe- Name Deutsche Saatveredelung cies. Breeding is run on nine breeding AG (DSV) stations in Europe and two in Canada. We are dedicated to our purpose: Innovation Address Weissenburger Straße 5 for your growth. Seed of new varieties is Postal Code/City 59557 Lippstadt produced and processed mostly in Europe Deutsche Saatveredelung AG is an inter- and sold world-wide. Fon +49 2941 296-0 national plant breeding company with In the framework of several coopera- Fax +49 2941 296-100 headquarters in Germany. The main focus tions in breeding, production, marketing E-Mail [email protected] is on research and development in breed- and sales DSV is partner of several com- Internet www.dsv-seeds.com ing and seed production for different crop petitive enterprises on the national and plant species. international level. Employees 600 Our major products include rapeseed, Founded (year) 1923 wheat, barley, corn/maize, pasture and

ready within the mycological product range Name MykoMax GmbH several self-developed mycorrhiza-inoculi. On short and medium-term the company MykoMax GmbH would development new Address Flieth 39 drugs from medicinal effective mush - Postal Code/City 42327 Wuppertal rooms for the pharmaceutical use. There- by the company uses a self-developed Fon +49 202 3171-320 method for the extraction of the active Fax +49 202 3171-3210 The company MykoMax was created in ingredients in the mushrooms. E-Mail [email protected] October 1999 in the legal form of a limited Internet www.mykomax.de company (GmbH). The enterprise article of the society is the study, development and Employees 3 production of biotechnology products on Founded (year) 1999 the basis of fungi. The company offers al-

61 agrobiotechnology BIO.NRW

Phytowelt offers solutions in plant breed- Name Phytowelt GreenTechnologies GmbH ing to improve plants by protoplast fusion and double haploid production Phytowelt’s Address Kölsumer Weg 33 improvement of biomass production by Postal Code/City 41334 Nettetal this accelerated breeding processes is the basis for the biorefinery concept to Fon +49 2162 77859 be realized in the coming years. The USP Fax +49 2162 89215 Phytowelt operates industrial plant bio- of a poplar breeding collection combined E-Mail [email protected] technology. It is a leading provider for the with the unique fermentation process for Internet www.phytowelt.com identification and expression of genes en- terpenes in E.coli, especially carotinoids is coding plant enzymes with new activities one of the success factors for Phytowelt. Employees 30 for industrial fermentation processes with The raspberry flavour, R-Alpha-Ionone will Founded (year) 1998 a main activity on fatty acids, terpenoids be one of the first products fermentatively and plant P450 enzymes. Additionally produced.

crops is strongly build upon innovation. Name Saaten-Union BIOTEC GmbH Application of tissue culture technolo - gies (doubled haploids, embryo rescue) Address Hovedisser Str. 94 and molecular marker applications are Postal Code/City 33818 Leopoldshöhe routinely used in a wide range of crops and Fon +49 5208 95971-0 for a significant number of breeding traits. Fax +49 5208 95971-96 E-Mail info@saaten-union- biotec.com Internet www.saaten-union- Saaten-Union Biotec offers services and biotec.de contract research in the field of plant Employees 80 breeding (rapeseed, barley, wheat, triti Founded (year) 1984 cale, oat, potato). The development of new varieties of cereals, rapeseed and other

62 BIO.NRW

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BIO Clustermanagement NRW GmbH phone: +49 (0) 211 942 150 49 Merowingerplatz 1 mail: [email protected] 40225 Düsseldorf, Germany web: www.bioclustermanagement.de 63 BIO.NRW

Bioinformatics

64 BIO.NRW bioinformatics

The high-throughput techniques performed Name IIT BioTech - Institut für by Illumina HiSeq and MiSeq or by IonTorrent Innovationstransfer an der PGM can be offered combined with a power- Universität Bielefeld GmbH ful lab & bioinformatic pipeline providing full service tasks like genomic assembly, gap Address Universitätsstr. 25 closure and annotation. University of Bielefeld Furthermore we offer individual solutions Postal Code/City 33615 Bielefeld for the bioinformatic evaluation of project Fon +49 521 106 8763 data. This includes construction of draft- Fax +49 521 106 89041 The Institut für Innovationstransfer GB genomics, storage/care of genome projects, E-Mail [email protected] Biotech (IIT Biotech) offers integrated analysis in resequencing and metagenomics Internet www.iit-biotech.de genomic services. Since some years the and development/customization of analysis- Employees 9 main provided service is the ’next genera- software. Founded (year) 1995 tion sequencing’.

e.g., every European National Health System Name Ridom GmbH Authority (e.g., RKI, RIVM, HPA, Serum Stat- ens) has bought in the last 10 years and is using since then at least one software product from Ridom. Ridom has pioneered typing ef- Address Mendelstr. 11 forts with a software tool for Staphylococcus Postal Code/City 48149 Münster aureus. The company has developed and maintains the worldwide largest sequence- Fon +49 251 490931-50 The Ridom GmbH (Münster, Germany) was based microbial typing database (Ridom Fax +49 251 490931-51 founded January 2003. The company devel- SpaServer). The SPA typing software Ridom E-Mail [email protected] ops software for DNA re-sequencing analysis StaphType is currently used by approximately Internet www.ridom.de for physicians and epidemiologists on routine 400 users in 36 different countries world- basis. The company has in the meantime by its wide. The new Ridom SeqSphere+ software Employees 4 software products a well-recognized name in provides a bacterial typing solution for any Founded (year) 2003 the field of sequence based microbial typing; bacteria, any study type, any lab.

Bioinformatics

65 BIO.NRW

Other Biotechnologically Active Companies

66 BIO.NRW other

principles of sustainable development and Name Bayer AG to its social and ethical responsibilities as a corporate citizen. In fiscal 2016, the Group employed around 115,200 people and had sales of EUR 46.8 billion. Capital expenditures amounted to EUR 2.6 billion, Address Kaiser-Wilhelm-Allee Bayer is a global enterprise with core R&D expenses to EUR 4.7 billion. Postal Code/City 51368 Leverkusen competencies in the Life Science fields These figures include those for the high- of health care and agriculture. Its prod- tech polymers business, which was floated Fon +49 214 30-1 ucts and services are designed to benefit on the stock market as an independent people and improve their quality of life. At company named Covestro on October 6, Internet www.bayer.com the same time, the Group aims to create 2015. value through innovation, growth and high Employees 115,000 earning power. Bayer is committed to the For more information, go to www.bayer.com.

vative prowess and integrated technology Name Evonik Industries AG platforms. Evonik is active in over 100 countries around the world. In fiscal 2015 more Address Rellinghauser Str. 1-11 than 33,000 employees generated sales Postal Code/City 45128 Essen Evonik, the creative industrial group from of around €13.5 billion and an operating Germany, is one of the world leaders in profit (adjusted EBITDA) of about €2.4 Fon +49 201 177 01 specialty chemicals. Profitable growth billion. Fax +49 201 177 3475 and a sustained increase in the value of Evonik innovates and serves the bioec- E-Mail [email protected] the company form the heart of Evonik’s onomy markets. Products are i. a. Biolys®, Internet www.evonik.com corporate strategy. Its activities focus DYNACOLL® Terra, DYNAPOL ® Terra, on the key megatrends health, nutrition, RESOMER®, ThreAMINO®, TrypAMINO®, Employees 33,000 resource efficiency and globalization. and VESTAMID® Terra. Founded (year) 2007 Evonik benefits specifically from its inno-

The main focus is on oilseed rape, potatoes, Name German Seed Alliance corn, sunflower, grasses, peas and cere- GmbH als (especially wheat, barley, rye, oat and triticale). German Seed Alliance coordinates Address Erdmund-Rumpler-Straße 6 all research programs of the group and is Postal Code/City 51149 Köln German Seed Alliance GmbH is an alliance partner of the national and international of four leading German plant breeding scientific community in plant research and Fon +49 2203 9888-20 companies in international agriculture: biotechnology. New varieties are developed Fax +49 2203 9888-229 Deutsche Saatveredelung, Norddeutsche and high quality seeds are produced for dif- E-Mail [email protected] Pflanzenzucht, Nordsaat Saatzucht and ferent climate regions. In sales the first focus Internet www.german-seed-alliance.de SaKa. The company and its shareholders are is on Russian Federation, with innovative internationally experienced enterprises in solutions and wide range of seed products Employees 45 Other Biotechnologically Active Companies the field of plant research and development, combined with professional service and Founded (year) 2008 breeding, seed production and distribution. individual consultancy.

67 other BIO.NRW

long track record of bringing innovative pain Name Grünenthal GmbH treatments and state-of-the-art technologies to patients. By sustainably investing in our R&D above the industrial average, we are Address Zieglerstr. 6 strongly committed to innovation. Postal Code/City 52099 Aachen The Grünenthal Group is present in 32 The Grünenthal Group is an entrepreneurial, countries with affiliates in Europe, Latin Fon +49 241 569-0 science-based pharmaceutical company America and the US. Grünenthal products E-Mail [email protected] specialized in pain, gout and inflammation. are sold in more than 155 countries and Internet www.grunenthal.com Our ambition is to deliver four to five new approx. products to patients in diseases with high 5,500 employees are working for the Employees 5,500 unmet medical need by 2022 and become a Grünenthal Group worldwide. In 2016, Grü- Founded (year) 1946 € 2 billion company. We are a fully integrated nenthal achieved revenues of € 1.4 bn. research & development company with a

wide. In its Laundry & Home Care and Name Henkel AG & Co. KGaA Beauty Care businesses, Henkel holds leading positions in many markets and categories around the world. Founded Address Henkelstr. 67 in 1876, Henkel looks back on more than Postal Code/City 40191 Düsseldorf Henkel operates globally with a well- 140 years of success. balanced and diversified portfolio. The Henkel employs more than 50,000 Fon +49 211 7979 630 company holds leading positions with people globally and reported sales of Fax +49 211 7982 245 its three business units in both indus - 18,7 bn euros in fiscal year 2016. Henkel’s Internet www.henkel.com trial and consumer businesses thanks to preferred shares are listed in the German strong brands, innovations and technolo- stock index DAX. Employees 50,000 gies. Henkel Adhesive Technologies is Founded (year) 1876 the global leader in the adhesives market – across all industry segments world -

and evaluates programmes that improve Name Janssen-Cilag GmbH therapies beyond the mere administration of drugs. Janssen is dedicated to address- Address Johnson & Johnson Platz 1 ing and solving the most important unmet Postal Code/City 41470 Neuss medical needs of our time, including oncology, immunology, neuroscience and Fon +49 2137 9550 infectious diseases. Driven by our commit- Fax +49 2137 955599 Janssen-Cilag is a research-based pharma- ment to patients, we develop sustainable, Internet www.janssen-deutschland.de ceutical company that develops and mar- integrated healthcare solutions by working kets pharmaceutical products and services. side-by-side with healthcare stakeholders, Employees 800 (Germany), The Janssen Pharmaceutical Companies of based on partnerships of trust and trans- 40,000 (worldwide) Johnson & Johnson with worldwide 40,000 parency. More information can be found at Founded (year) 1959 employees develop innovative medicines for www.janssen-emea.com and www.janssen- the treatment of severe chronic conditions deutschland.de

68 BIO.NRW other

conserving more of our world’s natural Name Monsanto Agrar resources such as water and energy. Deutschland GmbH

Address Vogelsanger Weg 91 Postal Code/City 40470 Düsseldorf

Monsanto Company is a leading global Fon +49 211 3675-0 provider of technology-based solutions and Fax +49 211 3675-362 agricultural products that improve farm E-Mail [email protected] productivity and food quality. Internet www.monsanto.de Monsanto remains focused on enabling both small-holder and large-scale farm- Founded (year) 2000 ers to produce more from their land while

an “Excellence company for Training and Name Pharma Waldhof GmbH Talent Management”. Development of new products using cutting-edge technology enables us to apply our high standards and Address Hansaallee 159 quality values into innovative, powerful and Postal Code/City 40549 Düsseldorf Since 70 years, Pharma Waldhof GmbH, lo- well-accepted products designed for existing cated in Düsseldorf/Germany, is active in the and new markets. Our success is based on Fon +49 211 52602-0 unique world of Nucleic Acid Biochemistry. our highly skilled people and pursuit for de- Fax +49 211 52602-60 The last milestones in our long company livering quality value added products serving E-Mail [email protected] history were in 2014 and 2016 the award of the worldwide market in various segments Internet www.pharmawaldhof.de the label “Innovative through Research” by like Pharma APIs and Intermediates; Cos- the “Stifterverband für die deutsche Wis- metics; Nutrition and Diagnostics. Pharma Employees 13 senschaft” and in 2015 the acknowledge- Waldhof belongs to the multi-national Aceto Founded (year) 1974 ment by the “Deutscher Bildungspreis” as Group/USA.

health and quality of life. At the core of Name Syngenta Seeds GmbH our business is innovation, particularly in research and development, combining chemical and biological expertise. Address Zum Knipkenbach 20 We harness our knowledge of agricul- Postal Code/City 32107 Bad Salzuflen Syngenta is one of the world’s leading ture and our understanding of growers to companies in agribusiness with more than develop integrated offers which will drive Fon +49 5222 5308-0 26,000 employees in over 90 countries. We land productivity in a sustainable way. E-Mail internet.marketing@ are dedicated to our purpose: Bringing plant syngenta.com potential to life. Internet www.syngenta.de Through world-class science, global reach and commitment to our customers Employees 150 we help to increase crop productivity, Founded (year) 2000 protect the environment and improve

69 other BIO.NRW

screening/focused library design and Name Taros Chemicals GmbH & Co. KG production, computer aided drug design, medicinal chemistry services engaged in Address Emil-Figge-Str. 76 A hit finding, hit to lead and lead optimiza- Postal Code/City 44227 Dortmund tion works as well as material science and specialty chemistry driven R&D services Fon +49 231 9742-7211 Taros, a privately owned CRO / CMO has including research, design, route scouting, Fax +49 231 9742-7219 been serving the needs of pharmaceutical, process development and non-GMP produc- E-Mail [email protected] chemical and biotech companies since tion & delivery of up to 1.000kg / year of Internet www.tarosdiscovery.com 1999. such performance chemicals. Taros Chemicals covers the full range Taros Chemicals is leading ELF’s chemis- Employees 65 of organometallic chemistry research and try activities since 2013. Founded (year) 1999 production from lab scale size to several hundred Kgs supply per year. This includes

biological pathways involved in severe Name UCB Pharma GmbH UCB Biosciences GmbH diseases. The complexities of severe diseases are beyond the expertise and resources of a single organisation. De - Address Alfred-Nobel-Str. 10 veloping and commercialising innovative Postal Code/City 40789 Monheim UCB is a global biopharmaceutical com- therapies is often the result of strong pany focusing on severe diseases in two partnerships. That is why we value part- Fon +49 2173 4848-48 therapeutic areas – CNS and immunol- nering with leading academic, biotech and Fax +49 2173 4848-41 ogy. UCB also has a selective presence in pharma companies to bring new solutions E-Mail [email protected] primary care. for patients. There is no such thing as Internet www.ucb.com; www.ucb.de UCB is connecting science in new ways, an “average patient”. We are seeking to notably chemistry and biology, so that embed the real needs of specific patient Founded (year) 1928 (Belgium) they can leverage the potential of these populations in our science and innovation

two disciplines, as well as illuminate the process.

C N WvB is nowadays well known for strong

Name W. von Borries-Eckendorf E

GmbH & Co. KG K breeding programs in oilseed rape, barley T Pflanzenzuchtbetrieb E and high yielding wheat varieties.

N R The company based in Lippe is founding

Address Hovedisser Strasse 94 D O member of the Rapool Ring GmbH and the Postal Code/City 33818 Leopoldshöhe O S Saaten-Union Biotec GmbH. R Fon +49 5208 9125-30 F E R Along with other breeding companies, Fax +49 5208 9125-49 Eckendorf is significantly involved in one E-Mail [email protected] of the largest distributors in the German Internet www.wvb-eckendorf.de W. von Borries-Eckendorf is a medium-sized sector of seed. The Saaten-Union GmbH. family-owned company, founded in 1849 by Employees 40 Wilhelm von Borries (1805-1890), a promi- Founded (year) 1849 nent farmer and talented plant breeder. Starting with the “Eckendorfer” fodder beet,

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BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der

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bioprocesses.

Firmenname

optimize and control their

research to better understand,

biotechnological and chemical

in Nordrhein-Westfalen

scientists in pharmaceutical,

fermentations. The company enables

• Laboratory equipment Biotech-Unternehmen

the analysis of shake-ﬂ ask

Subsector

development of laboratory devices for

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

Main Sector

BIO.NRW Description other

Baesweiler, North Rhine-Westphalia, Germany

aquila biolabs GmbH

Datenbanken

Unsere

Wissen

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bioprocesses.

optimize and control their

research to better understand,

biotechnological and chemical

Alle Veranstaltungen www.bio.nrw.de scientists in pharmaceutical,

fermentations. The company enables

• Laboratory equipment

the analysis of shake-ﬂ ask

Subsector

development of laboratory devices for

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

ZENIT GmbH, Mülheim an der Ruhr 09 Konversationen

Main Sector Description

große Chancen auf.

Baesweiler, North Rhine-Westphalia, Germany Industrie. Insbesondere im Bereich der Gesundheitswirtschaft tun sich für NRW-Unternehmen

2017 aquila biolabs GmbH companyJapan und Süd-Korea sinddat wichtige Absatzmärkte und Investitionsstandorteaba für die deutsche se

13. Juli

Marktchancen Japan / Südkorea

RWI4, Düsseldorf 04 Konversationen

Show Details

IngredientsWissenschaftsdatenbank - HiPerIn” durch CLIB2021Firmendatenbank organisiert. Downloads DE | EN Wissenschaftsdatenbank Firmendatenbank Downloads DE | EN

Dieses Forum wird im Rahmen des Projekts “Biotechnological Concepts for High Performance

• Proteomics

2017 Das nächste CLIB Forum befasst sich mit biotechnologischen Innovationen für Beschichtungen.

• Genomics

MS,...

06. Juli OK Newsletter-Anmeldung OK Newsletter-Anmeldung • Diagnostic instrumentation

CLIB-HiPerIn Forum “Biotech Innovations for Coatings” Pyrosequencing ® Technology, HPLC /

Search Clear

• Cell culture ( Microarray s), RT-qPCR / general PCR,

• Bioinformatics include Gene and protein analysis

services oﬀ ered by the company

Cluster Aktuelles Veranstaltungen Standort Finanzierung Kontakt • Biochips CeNTech, Münster 12 Konversationen

Aktuelles Veranstaltungen Standort analysisFinanzierung and bioinformatics. KontaktThe • Analytical services Subsidiary

culture management, HPLC / MS

• Other

Public (listed on stock exchange) Pyrosequencing® technology, cell

05.07.2017, ab 12:30 Uhr im Centrum für Nanotechnolog Subsector

on gene and protein analysis,

ﬁndet am Mittwoch, den „Liquid Biopsy – Vom Analyten über die Analytik zur Anwendung“ 57 Ergebnisse sortiert nach Firmennamen Sortieren nach: Firmenname

Private / independent

is a service laboratory with emphasis

2017

13. Arbeitsplattform des thematischen Schwerpunktes BIO.NRW.red zum Thema

arrows biomedical Deutschland GmbH Biotechnology / R&D Services [select all] Ownership

05. Juli

Main Sector Description 13. Arbeitsplattform „Liquid Biopsy" aquila biolabs GmbH

Biotech- Baesweiler, North Rhine-Westphalia, Germany

0 100.000

Köln, North Rhine-Westphalia, Germany

Employees worldwide arrows biomedical Deutschland GmbH

06 Konversationen San Diego Convention Center, USA Unternehmen Main Sector Description Supplier & Engineering aquila biolabs is a German technology

in Nordrhein- company that focuses on the 50 200

Biotechnology NRW cordially invite you visit us at our booth (4507) in the German Pavilion. development of laboratory devices for

Herzlich Willkommen Employees at domicil Subsector 2017 the analysis of shake-ﬂ ask

The Government of the German State of North Rhine-Westphalia (NRW) and BIO.NRW Cluster Westfalen • Laboratory equipment fermentations. The company enables

19. - 22. Juni

Show Details BIO International Convention 2017 On the market scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical

Phase III research to better understand,

dem (Bundes)land der Biotechnologie CompanyPhase nameII

optimize and control their bioprocesses.

Veranstaltungen

Kommende Phase I

On the market bioprocesses.

optimize and control their

In development Preclinical

research to better understand,

[select all] [select all] Medtech Biotech

biotechnological and chemical Veranstaltungen

Show Detailsscientists in pharmaceutical,

fermentations. The company enables

• Laboratory equipment

AdvancedIndirect (independent Search dealer) the analysis of shake-ﬂ ask

Subsector

development of laboratory devices for

FreeDirect text (own sales force)

company that focuses on the

[select all] Distribution aquila biolabs is a German technology Supplier & Engineering Main Sector

Ares BioscienceDescription GmbH

Alle Nachrichten

MainPhysicians sector / doctors Köln, North Rhine-Westphalia, Germany

Baesweiler, North Rhine-Westphalia, Germany BiotechnologyLarge medtech - Therapeutics and Diag…

Main Sector aquila biolabsDescription GmbH

Large biotech and big Pharma Biotechnology / R&D Services Ares Bioscience GmbH is a

05. bis 06.04.2017 in Hannover Subsector [select all]

Cluster BIO.NRW Biotech Standort NRW Startups & Finanzierung Hospitals biotechnology company which

Biotechnologietage 2017 –

Wachstumskurs Analytical services develops and markets molecular

Consumer (mass market) Subsector Nachbericht - Die Deutschen EU-Darlehen für Biofronteras biology products to life sciences BIO.NRW aktiviert Kooperationen zwischen …ist eine sich dynamisch entwickelnde Technologie BIO.NRW.red als strategische Initative für ein

Biochips • Other market. The company provides PCR

Other

08. Juni 2017

Forschung, Unternehmen, Investoren und Politik aus den in NRW traditionell starken Industrien 05.stabiles Juni und 2017 dauerhaftes Netzwerk aus Experten • Analytical services

Bioinformatics Show Detailsenzymes, restriction enzymes,

[select all] auf Landesebene, national und international. Energie, Stahl und Chemie. der roten Biotechnologie. Customer segments • Synthesis services nucleotides, DNA/RNA modifying

Cell culture enzymes, DNA molecular weight

Forschungsrat markers, products for molecular

• Proteomics

DiagnosticResearch on Instrumentation contract basis BIO.NRW.academy am 3. Mai in Hamm

Millionenförderung vom Europäischen biology, and reagents for

• Genomics

mehr erfahren mehr erfahren mehr erfahren MS,...electrophoresis. Fit für die Zukunft? Max-Planck-Institute feiern

R&D

Genomics • Diagnostic instrumentation Pyrosequencing ® Technology, HPLC /

• Cell culture 09. Juni 2017 06. Juni 2017

( Microarray s), RT-qPCR / general PCR,

Out-licensing

• Bioinformatics

Primary therapeutic areas [select all] Show Detailsinclude Gene and protein analysis

services oﬀ ered by the company • Biochips Manufacturer

analysis and bioinformatics. The Aviv auf Understanding Cardiovascular • Analytical services

In-licensing

culture management, HPLC / MS

• Other Kooperationsscout nimmt Arbeit in Tel

unterzeichnet Memorandum of Conditions originating in the perinatal pe…

Aktuelles Pyrosequencing® technology, cell

Subsector

Other

NRW-Investitions- und Delegation der China Medical City

Congenital malformations, deformations… on gene and protein analysis,

[select all] Business Model is a service laboratory with emphasis 12. Juni 2017 07. Juni 2017

arrows biomedical Deutschland GmbH

Aktuelle Biotechnology / R&D Services

Nachrichten Digestive system arrows biomedical Deutschland GmbH

Main Sector

Köln, North Rhine-Westphalia,Description Germany Wissenschaft und Wirtschaft

BIO.NRW Cluster Diseases of the blood and blood-forming… Diseases of the ear

Diseases of the ear Diseases of the blood and blood-forming…

Wissenschaft und Wirtschaft BIO.NRW Cluster Main Sector Köln, North Rhine-Westphalia,Description Germany

arrows biomedical Deutschland GmbH

Digestive system Biotechnology / R&D Services arrows biomedical Deutschland GmbH

Nachrichten

Aktuelle Business Model [select all] is a service laboratory with emphasis 12. Juni 2017 07. Juni 2017 Congenital malformations, deformations… on gene and protein analysis, Other

NRW-Investitions- und Delegation der China Medical City Subsector Pyrosequencing® technology, cell Conditions originating in the perinatal pe… Aktuelles • Other Kooperationsscout nimmt Arbeit in Tel unterzeichnet Memorandum of In-licensing culture management, HPLC / MS

• Analytical services

Aviv auf Understanding Cardiovascular analysis and bioinformatics. The

Manufacturer • Biochips services oﬀ ered by the company

[select all] Primary therapeutic areas • Bioinformatics Show Detailsinclude Gene and protein analysis Out-licensing • Cell culture ( Microarray s), RT-qPCR / general PCR,

09. Juni 2017 06. Juni 2017 Pyrosequencing ® Technology, HPLC /

R&DGenomics • Diagnostic instrumentation

Max-Planck-Institute feiern Fit für die Zukunft? MS,...electrophoresis. mehr erfahren mehr erfahren mehr erfahren • Genomics

biology, and reagents for ResearchDiagnostic on Instrumentation contract basis

Millionenförderung vom Europäischen BIO.NRW.academy am 3. Mai in Hamm • Proteomics

Innovative biotech companies in North Rhine-Westphalia. BIO.NRW offers free ofmarkers, charge products for molecular a well-or-

Cell culture Forschungsrat enzymes, DNA molecular weight

nucleotides, DNA/RNA modifying

Customer segments [select all] • Synthesis services

Bioinformatics

auf Landesebene, national und international. Energie, Stahl und Chemie. der roten Biotechnologie.

Show Detailsenzymes, restriction enzymes,

Other • Analytical services

market. The company provides PCR

Forschung, Unternehmen, Investoren und Politik aus den in NRW traditionell starken Industrien

08. Juni 2017 05.stabiles Juni und 2017 dauerhaftes Netzwerk aus Experten • Other Biochips

biology products to life sciences BIO.NRW aktiviert Kooperationen zwischen …ist eine sich dynamisch entwickelnde Technologie BIO.NRW.red als strategische Initative für ein ganized and comprehensive database of life science and biotechConsumer (mass market) companiesSubsector resident in North Rhine-

EU-Darlehen für Biofronteras Nachbericht - Die Deutschen

develops and markets molecular Analytical services

Wachstumskurs Biotechnologietage 2017 – biotechnology company which Cluster BIO.NRW Biotech Standort NRW Startups & Finanzierung Hospitals

[select all] Subsector

Ares Bioscience GmbH is a 05. bis 06.04.2017 in Hannover Biotechnology / R&D Services

Large biotech and big Pharma Main Sector

Westphalia. The database currently includes 450 company profiles, contact detailsaquila biolabsDescription GmbHand a summary of BiotechnologyLarge medtech - Therapeutics and Diag…

Baesweiler, North Rhine-Westphalia, Germany

Main sector

Physicians / doctors Köln, North Rhine-Westphalia, Germany Alle Nachrichten Ares Bioscience GmbH Main Sector Description products, services and technologies and is updated frequently several timesSupplier & Engineering per year.aquila biolabs is a German technology Distribution [select all]

company that focuses on the FreeDirect text (own sales force) development of laboratory devices for

Subsector the analysis of shake-ﬂ ask AdvancedIndirect (independent Search dealer)

• Laboratory equipment fermentations. The company enables Show Detailsscientists in pharmaceutical, Veranstaltungen Biotech [select all] Medtech [select all] biotechnological and chemical research to better understand, Preclinical In development

optimize and control their phone: +49 211 38 54 69-9200 • E-Mail: [email protected].

Phase I On the market bioprocesses.

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dem (Bundes)land der Biotechnologie Phase III biotechnological and chemical

in Nordrhein-Westfalen

On the market Show Detailsscientists in pharmaceutical,

BIO International Convention 2017

fermentations. The company enables

19. - 22. Juni Westfalen • Laboratory equipment

the analysis of shake-ﬂ ask

2017 The Government of the German State of North Rhine-Westphalia (NRW) and BIO.NRW Cluster Employees at domicil Subsector

Herzlich WillkommenBiotechnology NRW cordially invite you visit us at our booth (4507) in the German Pavilion. 50 200 development of laboratory devices for in Nordrhein-

company that focuses on the

aquila biolabs is a German technology Supplier & Engineering

Main Sector Description

San Diego Convention Center, USA 06 Konversationen EmployeesUnternehmen worldwide arrows biomedical Deutschland GmbH

0 100.000 Köln, North Rhine-Westphalia, Germany

Biotech- Baesweiler, North Rhine-Westphalia, Germany

13. Arbeitsplattform „Liquid Biopsy" Main Sector aquila biolabsDescription GmbH 05. Juli Ownership [select all] Biotechnology / R&D Services arrows biomedical Deutschland GmbH

is a service laboratory with emphasis

2017 13. Arbeitsplattform des thematischen Schwerpunktes BIO.NRW.red zum Thema Private / independent

57 Ergebnisse sortiert nach Firmennamen Firmenname „Liquid Biopsy – Vom Analyten über die Analytik zur Anwendung“ ﬁndet am Mittwoch, den on gene and proteinSortieren analysis, nach: Subsector 05.07.2017, ab 12:30 Uhr im Centrum für Nanotechnolog Public (listed on stock exchange) Pyrosequencing® technology, cell • Other culture management, HPLC / MS

Subsidiary • Analytical services Veranstaltungen Standort Finanzierung Kontakt Aktuelles analysis and bioinformatics. The

CeNTech, Münster 12 Konversationen Cluster s Veranstaltungen Standort Finanzierung Kontakt Aktuelle • Biochips services oﬀ ered by the company • Bioinformatics include Gene and protein analysis Search Clear • Cell culture ( Microarray s), RT-qPCR / general PCR,

• Diagnostic instrumentation Pyrosequencing ® Technology, HPLC / Newsletter-Anmeldung

CLIB-HiPerIn Forum “Biotech Innovations for Coatings” OK Newsletter-Anmeldung OK MS,... 06. Juli • Genomics 2017 Das nächste CLIB Forum befasst sich mit biotechnologischen Innovationen für Beschichtungen. • Proteomics

Dieses Forum wird im Rahmen des Projekts “Biotechnological Concepts for High Performance Wissenschaftsdatenbank Firmendatenbank Downloads DE EN |

Wissenschaftsdatenbank Firmendatenbank Downloads DE EN Ingredients - HiPerIn” durch CLIB2021 organisiert. | Show Details

RWI4, Düsseldorf 04 Konversationen

13. Juli Marktchancen Japan / Südkorea aquila biolabs GmbH Japan und Süd-Korea sind wichtige Absatzmärkte und Investitionsstandorte für die deutsche 2017 Baesweiler, North Rhine-Westphalia, Germany Industrie. Insbesondere im Bereich der Gesundheitswirtschaft tun sich für NRW-Unternehmen große Chancen auf. Main Sector Description ZENIT GmbH, Mülheim an der Ruhr 09 Konversationen Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, Alle Veranstaltungen biotechnological and chemical research to better understand, optimize and control their bioprocesses.

Show Details Wissen Unsere Datenbanken

aquila biolabs GmbH Baesweiler, North Rhine-Westphalia, Germany

Main Sector Description Supplier & Engineering aquila biolabs is a German technology company that focuses on the development of laboratory devices for Subsector the analysis of shake-ﬂ ask Biotech-Unternehmen • Laboratory equipment fermentations. The company enables scientists in pharmaceutical, in Nordrhein-Westfalen biotechnological and chemical research to better understand, optimize and control their Firmenname bioprocesses.

Show Details Erweiterte Suche

BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der BIO.NRW stellt Ihnen hier kostenlos eine übersichtliche und umfassende Datenbank der Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen Life Science und Biotechnologiefirmen aus Nordrhein-Westfalen zur Verfügung. Die zur Verfügung. Die Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien. Information umfasst Firmenprofile, Kontaktdetails, sowie einer Zusammenfassung der Produkte, Serviceleistungen und Technologien.

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This academic database is the ﬁrst of its kind in Germany and aims to facilitate collaboration between industry and academia. The database is being launched in fall 2010 In unserem Downloadcenter ﬁnden Sie Publikationen, Vorträge und by Venture Valuation and BIO.NRW. There are currently over 1000 working groups in North Präsentationen zum Download. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Rhine Westphalia listed. The organizations are currently in the process of up-dating and Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et complementing their data. magnis dis parturient montes, nascetur ridiculus mus.

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Impressum BIO.NRW folgen

BIO.NRW Cluster Biotechnology North Rhine-Westphalia

North Rhine-Westphalia is situated at Eu- dialogue between all stakeholders in the biotech developments in NRW please visit rope’s geographic and economic center. It field of biotechnology and to encourage www.bio.nrw.de. is the largest of Germany’s 16 federal states, cooperation. and the number one exporter. If classified Further drivers in the field are dynamic local as an independent exporting nation, NRW Biotech Business & Sciences biotechnology initiatives and networks: would rank 19th in the world, on a par with the BIO.NRW compiles comprehensive and Netherlands. current online databases of the academic Bioanalytik-Münster North Rhine-Westphalia’s state govern- institutions and companies active in the life www.bioanalytik-muenster.de ment has established a number of technology sciences in NRW. Free to access and easy- clusters to systematically improve NRW’s to-use, these resources are valuable tools for BioCologne strengths and talents in established industries identifying prospective business partners. www.biocologne.de and up-and-coming fields like biotechnology. More information on www.bio.nrw.de North Rhine-Westphalia’s biotechnol- bio.dortmund ogy cluster BIO.NRW is a central catalyst for Fairs, Exhibitions and Conferences www.wirtschaftsfoerderung-dortmund.de the sustainable development of the state’s Companies and academic institutions can biotech sector. It activates cooperation generate awareness of their activities locally, BioIndustry between business, research, investors and nationally and internationally by being a part www.bioindustry.de policy-makers. The cluster also promotes the of the BIO.NRW common stands on fairs, strengths and achievements of biotechnology exhibitions and conferences. BIO.NRW also BioRiver in the state. organizes a series of workshops and sympo- www.bioriver.de sia, called BIO.NRW.academy. To support young as well as already estab- Bio-Tech-Region OWL lished biotech companies, BIO.NRW offers Support of Young Professionals www.bio-owl.de the following core competencies: BIO.NRW takes a special interest in support- – Individual matchmaking for collabora- ing young professionals in biotechnology. LifeScienceNet Düsseldorf tions and partners For example, we organize conventions where www.lifescience-dus.de – Overview on all up-to-date R&D activi- graduates meet representatives from indus- ties in industry and academia try and academic science. The ‘Business MedLife (Aachen) – Profound knowledge on financing pos- Angel Network – BIO.NRW’ helps financing www.medlife-ev.de sibilities and funding biotech start-ups. In addition, – International promotion and marketing a forum that brings together investment Cluster Industrial Biotechnology for NRW as biotech location institutions, private investors and business www.CLIB2021.com – Direct contacts to decision makers angels and developers provides information about the current NRW biotech scene. Our services include These meetings are a valuable opportunity for start-up companies to receive coaching Technology Transfer and financing. Tech transfer support is a key contribution from BIO.NRW. We organize events, work- To learn more about the Cluster BIO.NRW ing platforms and meetings to promote the and to stay informed about the latest

72 Denmark BIO.NRW

Kiel Hamburg

Bremen Schwerin Netherland Berlin Poland

Magdeburg

Hannover Potsdam

j Düsseldorf

Dresden Belgium Erfurt Frankfurt

Luxembourg Mainz Czech Republic

Saarbrücken

Stuttgart

France München Austria

Switzerland 73 BIO.NRW

Glossary

Organisation for Economic Other biotechnologically active Contact BIO.NRW Co-operation and Development companies (OECD) Dr. Christoph Block … firms that apply biotechnology techniques Head of office BIO.NRW The OECD is a unique forum where the gov- for the purpose of implementing new or sig- Merowingerplatz 1 ernments of 30 democracies work together nificantly improved products or processes. 40225 Düsseldorf, Germany to address the economic, social and environ- This definition excludes end users that Fon +49 211 385469-9202 mental challenges of globalisation. innovate simply by using biotechnol - Fax +49 211 385469-9220 The OECD Biotechnology Statistics, which ogy products as intermediate inputs (for [email protected] brings together the latest available economic instance, detergent manufacturers that www.bio.nrw.de and activity data on biotechnology and in- change a formulation to include enzymes novation, is collected by OECD member and produced by other firms via biotechnology Sources, Literature, Links non-member countries. techniques). The report builds on the extensive work [1] www.nrwinvest.com/fileadmin/user_up- of the OECD and national experts to im - Business Areas of Activity load/downloads/DE-Broschueren/NI- Standortbroschuere-DE-2016.pdf prove the comparability of biotechnology [2] KPMG - Der perfekte Start: Deutscher statistics. – Health/Medicine Startup Monitor 2016 www.oecd.org (including animal health) [3] Analysis by BIO.NRW and BIO Deutschland Development of therapeutics and/or diag- e.V. nostics for the field of human medicine, drug [4] Bio based Industries Consortium - Strategic delivery, human tissue replacement. Innovation & Research Agenda; May 2017 OECD Definitions [5] OECD Biotechnology Statistics 2009, B. van Beuzekom and A. Arundel – Agri/Agrobiotechnology [6] NRW PCT Biotech Patent Analysis by BIO.NRW Biotech focussed on genetically modified [7] Statista Biotechnology company plants, animals or microorganisms, as well [8] Spot on Innovation! ; Deutscher Biotechnol- as non-genetically modified plants grown ogie-Report 2017, Ernst & Young GmbH … is defined as a application of science and using biotechnological procedures for use in [9] http://data.worldbank.org/indicator/ technology to living organisms, as well as agriculture or forestry. GB.XPD.RSDV.GD.ZS parts, products and models thereof, to alter [10] www.biotechgate.com; Venture Valuation, Zurich, CH living or non-living materials for the produc- – Industrial biotechnology [11] The Germany Biotechnology Sector 2017; tion of knowledge, goods and services. Biotechnological products and processes for BIOCOM AG the handling of waste or sewage, for chemical [12] Biotech-Report “Medizinische Biotechnolo- Dedicated biotechnology synthesis, for the extraction of raw materials gie in Deutschland 2017” von vfa bio und companies and energy, etc. BCG; www.vfa-bio.de [13] www.leitmarktagentur.nrw/leitmarktwettbewerbe/lifesciences … are defined as biotechnology active firms – Non-specific application whose predominant activities involve the Equipment or reagents based on biotechno- application of biotechnology techniques to logical principles for research or provision of produce goods or services and/or the per- services in this field (“ancillary industry”). formance of biotechnology R&D. Source: biotechnologie.de

Online Company Company Database Directory www.bio.nrw.de

BIO.NRW Merowingerplatz 1 40225 Düsseldorf,Duesseldorf Germany Germany Fon +49 211 385469-9200 Fon + 49 (0) 2 11 385 469 - 9200 Fax +49 211 385469-9220 Fax + 49 (0) 2 11 385 469 - 9220 [email protected] www.bio.nrw.de

Ministry of EconomicInnovation, Affairs, Science, Innovation, DigitizationResearch and and Technology Energy of ofthe the State ofState North of NorthRhine-Westphalia Rhine-Westphalia 4021340221 DüsseldorfDuesseldorf www.innovation.nrw.de www.wirtschaft.nrw www.exzellenz.nrw.de ‘Excellence NRW’ stands for the cluster strategy in North Rhine-Westphalia, an innovative location for business. The state government www.bio.nrw.de Spot on Biotechnology Business 2017/2018 there wants to improve on its strengths, and systematically strive for excellence in NRW. The goal of the cluster policy is to create an environment that is friendly to innovation, strengthens the competitive edge of the businesses there, and stimulates growth and employment. To find out more about NRW’s cluster strategy and the 16 clusters in the state, just visit: www.exzellenz.nrw.de