0.8 exposure exposure Trend UC * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−724: superpathway of L−lysine, L−threonine and L−methionine biosynthesis II 0.4 CD * * * * * * * * * * * * * * * * * * * * * * * PWY−7111: pyruvate fermentation to isobutanol (engineered) CRC * * * * * * * * * * * * * * * * * * * * * * * * * * ILEUSYN−PWY: L−isoleucine biosynthesis I (from threonine) Common * * * * * * * * * * * * * * * * * * * * * * * * * * VALSYN−PWY: L−valine biosynthesis 0 * * * * * * * * * * * * * * * * * * * * * * * * * * * NONMEVIPP−PWY: methylerythritol phosphate pathway I * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−7357: thiamin formation from pyrithiamine and oxythiamine (yeast) * * * * * * * * * * * * * * * * * * * * * * PWY−6163: chorismate biosynthesis from 3−dehydroquinate −0.4 * * * * * * * * * * * * * * * * * * * ARO−PWY: chorismate biosynthesis I * * * * * * * * * * * * * * * * * * * * COMPLETE−ARO−PWY: superpathway of aromatic amino acid biosynthesis * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−3001: superpathway of L−isoleucine biosynthesis I * * * * * * * * * * * * * * * * * * * * * * * * * * * BRANCHED−CHAIN−AA−SYN−PWY: superpathway of branched amino acid biosynthesis −0.8 * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−5103: L−isoleucine biosynthesis III Trend * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PRPP−PWY: superpathway of histidine, purine, and pyrimidine biosynthesis Control−enriched * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * TRNA−CHARGING−PWY: tRNA charging Case−enriched * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * HSERMETANA−PWY: L−methionine biosynthesis III * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PYRIDNUCSYN−PWY: NAD biosynthesis I (from aspartate) Conflict * * * * * * * * * * * * * * * * * * * * * * * PWY0−781: aspartate superpathway * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−5347: superpathway of L−methionine biosynthesis (transsulfuration) Superclass * * * * * * * * * * * * * * * * * * * * * * * * * * HOMOSER−METSYN−PWY: L−methionine biosynthesis I Fermentation * * * * * * * * * * * * * * * * * * * * * * * * * * * MET−SAM−PWY: superpathway of S−adenosyl−L−methionine biosynthesis Generation of Precursor Metabolites and Energy * * * * * * * * * * * * * * * * * * * * * * * * * * * * METSYN−PWY: L−homoserine and L−methionine biosynthesis Inorganic Nutrient Metabolism * * * * * * * * * * * * * * * * * * * * * * * * THISYNARA−PWY: superpathway of thiamin diphosphate biosynthesis III (eukaryotes) * * * * * * * * * * * * * * * PWY−6123: inosine−5'−phosphate biosynthesis I Aminoacyl−tRNA Charging * * * * * * * * * * * * * * PWY−6124: inosine−5'−phosphate biosynthesis II Amino Acid Biosynthesis * * * * * * * * * * * * * * * * PWY−5104: L−isoleucine biosynthesis IV Glycolysis * * * * * * * * PWY−5304: superpathway of sulfur oxidation (Acidianus ambivalens) * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−6151: S−adenosyl−L−methionine cycle I Aromatic Compound Biosynthesis * * * * * * * * * * * * * * * * * * PWY−7196: superpathway of pyrimidine ribonucleosides salvage Carbohydrate Biosynthesis * * * * * * * * * * * * * * * * * * * * * * * * * * * GLYCOLYSIS−E−D: superpathway of glycolysis and Entner−Doudoroff Secondary Metabolite Biosynthesis * * * * * * * * * * * * * * * * * PENTOSE−P−PWY: pentose phosphate pathway * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ANAEROFRUCAT−PWY: homolactic fermentation Cofactor, Carrier, and Vitamin Biosynthesis * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−1269: CMP−3−deoxy−D−manno−octulosonate biosynthesis I Fatty Acid and Lipid Biosynthesis * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−6125: superpathway of guanosine nucleotides de novo biosynthesis II Nucleoside and Nucleotide Biosynthesis * * * * * * * * * * * * * * * * * * * PWY−7220: adenosine deoxyribonucleotides de novo biosynthesis II * * * * * * * * * * * * * * * * * * * PWY−7222: guanosine deoxyribonucleotides de novo biosynthesis II * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * GLYCOLYSIS: glycolysis I (from glucose 6−phosphate) * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−5484: glycolysis II (from fructose 6−phosphate) * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY66−400: glycolysis VI (metazoan) * * * * * * * * * * * * * * * * * * * * * * * * PHOSLIPSYN−PWY: superpathway of phospholipid biosynthesis I (bacteria) * * * * * * * * * * * * * * * * * * * PWY4FS−7: phosphatidylglycerol biosynthesis I (plastidic) * * * * * * * * * * * * * * * * * * * PWY4FS−8: phosphatidylglycerol biosynthesis II (non−plastidic) * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY66−399: gluconeogenesis III * * * * * * * * * * * * PWY−5676: acetyl−CoA fermentation to butanoate II * * * * * * * * * * * * * * * * * * * * P108−PWY: pyruvate fermentation to propanoate I * * * * * * * * * * * * * * * * GLUCONEO−PWY: gluconeogenesis I * * * * * * * * * * * * * * * PWY−5345: superpathway of L−methionine biosynthesis (by sulfhydrylation) * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PANTO−PWY: phosphopantothenate biosynthesis I * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−6168: flavin biosynthesis III (fungi) * * * * * * * * * * * * * * * * * * * * * * * * * * * PWY−4984: urea cycle * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ARGININE−SYN4−PWY: L−ornithine de novo biosynthesis * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * PYRIDOXSYN−PWY: pyridoxal 5'−phosphate biosynthesis I Trend Superclass Streptococcus mitis oralis pneumoniae sp KLE 1755 Clostridium Anaerococcus vaginalis Flavonifractor plautii Ruminococcus gnavus Acidaminococcus intestini Lactobacillus fermentum Streptococcus parasanguinis Veillonella atypica Veillonella parvula Veillonella spp. Citrobacter freundii Citrobacter spp. coli Escherichia Klebsiella pneumoniae Klebsiella spp. Slackia spp. Bacteroides fragilis Bacteroides salyersiae Porphyromonas asaccharolytica Porphyromonas somerae Porphyromonas uenonis Prevotella intermedia Alistipes sp AP11 Granulicatella adiacens Streptococcus anginosus asparagiforme Clostridium hathewayiClostridium Parvimonas micra Parvimonas spp. 1 7 47FAA bacterium Clostridiales 3 1 57FAALachnospiraceae bacterium CT1 7 1 58FAALachnospiraceae bacterium Peptostreptococcus anaerobius Peptostreptococcus spp. colihominis Anaerotruncus spp.Anaerotruncus D16 Ruminococcaceae bacterium Subdoligranulum sp 4 3 54A2FAA 2 44A bacterium Erysipelotrichaceae Megasphaera spp. nucleatum Fusobacterium Bilophila wadsworthia Desulfovibrio desulfuricans Synergistes sp 3 1 syn1 Gemella morbillorum bolteae Clostridium citroniae Clostridium symbiosum Clostridium Peptostreptococcus stomatis moorei Solobacterium Alistipes onderdonkii Ruminococcus torques Bacteroides cellulosilyticus Bacteroides thetaiotaomicron adolescentis Bifidobacterium Bacteroides nordii Bacteroides plebeius Bacteroides stercoris Bacteroides vulgatus ph8 Bacteroidales bacterium laneus Odoribacter Parabacteroides goldsteinii Alistipes putredinis Alistipes senegalensis Alistipes shahii leptum Clostridium Bacteroides pectinophilus siraeum Eubacterium ventriosum Eubacterium Coprococcus catus Roseburia hominis Roseburia inulinivorans Ruminococcus lactaris Ruminococcus sp 5 1 39BFAA Megamonas hypermegale Megamonas spp. Coprococcus comes Roseburia intestinalis Alistipes finegoldii hallii Eubacterium Anaerostipes hadrus 5 1 63FAALachnospiraceae bacterium Ruminococcus bromii Subdoligranulum spp.