Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York Tuesday, Track One Track Two Track Three Track Four Track Five Track Six Track Seven November 29 Villard - 2nd floor Drawing Rm - 3rd floor Holmes 1 - 4th floor Holmes 2 - 4th floor Louis - 4th floor Kennedy 1 - 4th floor Kennedy 2 - 4th floor Registration – Villard Foyer, 2nd Floor Public & Private Company 7:30 Private Company Track Continental Breakfast – Reid Salon, 2nd Floor Track Public companies presenting in this track will be available for networking in the Reid Room, 2nd floor at a hosted table for up to 2 hours following their presentation.

Endo Pharmaceuticals Gen-Probe Incorporated Osiris Therapeutics, Astex Pharmaceuticals, 8:00 - 8:30 Johnson & Johnson (JNJ) AmSurg Corp. (AMSG) 8:10 Colibri Heart Valve, LLC Holdings Inc. (ENDP) (GPRO) Inc. (OSIR) Inc. (ASTX)

Allon Therapeutics, Inc. Fresenius Medical Care Wright Medical Group, AVI Biopharma, Inc. 8:30 Precision Dynamics Inc. 8:30 - 9:00 Theravance Inc. (THRX) Sequenom Inc. (SQNM) (NPC) AG (FMS) Inc. (WMGI) (AVII) 8:50 Cardiocore Lab, Inc.

Gilead Sciences, Inc. Medicis Pharmaceutical MedAssets, Inc. New American 9:00 - 9:30 Medtronic,,() Inc. (MDT) NuVasive,,( Inc. (NUVA ) 9:10 SurModics Inc. (()SRDX) (GILD) C(MRX)Corp. (MRX) (MDAS) Therapeu tics, Inc.

Curaspan Health Group, 9:30 Cardica Inc. (CRDC) Thoratec Corporation Masimo Corporation AcelRx Pharmaceuticals, Nektar Therapeutics Inc. 9:30 - 10:00 (THOR) (MASI) Inc. (ACRX) (NKTR) Vascular Solutions Inc. 9:50 (VASC)

Becton, Dickinson and Hill-Rom Holdings, Inc. Rochester Medical Emergent BioSolutions, NDS Surgical Imaging, 10:00 - 10:30 Evolving Landscape for Micromet, Inc. (MITI) 10:10 Company (BDX) (HRC) Corp. (ROCM) Inc. (EBS) LLC Treatment of MS Panel Co-Moderators: REVA Medical, Inc. 10:30 CardioFocus, Inc. David Amsellem and Ian ArthroCare Corporation The Spectranetics Trius Therapeutics, Inc. (RVA.AX) 10:30 - 11:00 Santarus Inc. (SNTS) Somaiya (ARTC) Corporation (SPNC) (TSRX) OraSure Technologies Inc. 10:50 AngioScore, Inc. (OSUR) Celgene Corporation , Inc. AngioDynamics Inc. 11:00 - 11:30 Steris Corp. (STE) 11:10 BioHorizons, Inc. Metabolex, Inc. (CELG) Inc. (VRTX) (ACOR) (ANGO)

Salix Pharmaceuticals, Nxstage Medical, Inc. Array BioPharma Inc. 11:30 Sonitus Medical Inc. Pearl Therapeutics, Inc. 11:30 - 12:00 QIAGEN N.V. (QGEN) Conceptus, Inc. (CPTS) Ltd. (SLXP) (NXTM) (ARRY) 11:50 EBR Systems, Inc. Chimerix, Inc. 12:00 Visit the Reid Salon-2nd floor or Holmes Foyer-4th floor to pick-up a boxed lunch Pacira Washington Update: Seattle Genetics Inc. Natus Medical Inc. Alphatec Holdings, Inc. 12:00 - 12:30 Pharmaceuticals, Inc. 12:10 Cellnovo Limited CardioDx, Inc. Provider and Payor (SGEN) (BABY) (ATEC) (PCRX) Outlook for Medical 12:30 Inogen, Inc. XDx, Inc. Technology Alnylam

ScheduleforTuesday,November29,2011Page1of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York Tuesday, Track One Track Two Track Three Track Four Track Five Track Six Track Seven November 29 Villard - 2nd floor Drawing Rm - 3rd floor Holmes 1 - 4th floor Holmes 2 - 4th floor Louis - 4th floor Kennedy 1 - 4th floor Kennedy 2 - 4th floor Technology Alnylam Quality Systems, Inc. Peregrine Pharmaceuticals 12:30 - 1:00 Moderator: Thom ResMed Inc. (RMD) Pharmaceuticals, Inc. Revance Therapeutics, (QSII) Inc. (PPHM) 12:50 GetWellNetwork, Inc. Gunderson (ALNY) Inc.

Regeneron Inc. DURECT Corporation 1:00 - 1:30 Pharmaceuticals Inc. DexCom, Inc. (DXCM) Affymetrix, Inc. (AFFX) 1:10 Regulus Therapeutics, LLC PatientKeeper, Inc. (BAX) (DRRX) (REGN) Anthera Novo Nordisk A/S Genomic Health, Inc. Insulet Corporation 1:30 Flexion Therapeutics, Inc CVRx, Inc. 1:30 - 2:00 VCA Antech, Inc. (WOOF) Pharmaceuticals, Inc. (NOVOB DC) (GHDX) (PODD) (ANTH) 1:50 GlobeImmune, Inc. DFine, Inc.

Volcano Corporation Infinity Pharmaceuticals, Symmetry Medical Inc. Derma Sciences Inc. OncoMed 2:00 - 2:30 China Healthcare Market: 2:10 Ulthera Inc. (VOLC) Inc. (INFI) (SMA) (DSCI) Pharmaceuticals, Inc. Opportunities and Challenges 2:30 PerfectServe, Inc. Topera, Inc. IPC The Hospitalist Co. AMAG Pharmaceuticals, Aastrom Biosciences, 2:30 - 3:00 Moderator: Hao Zhou Omnicell, Inc. (OMCL) (IPCM) Inc. (AMAG) Inc. (ASTM) 2:50 e+CancerCare Lutonix Inc.

Pacific Biosciences of 3:00 - 3:30 Algeta ASA (ALGETA NO) Zoll Medical Corp. (ZOLL) Novavax, Inc. (NVAX) Zogenix, Inc. (ZGNX) 3:10 Suture Express, Inc. California, Inc. (PACB) 3:30 Home Solutions, Inc. Pulmonx Corporation Allscripts Healthcare Pernix Therapeutics Tranzyme, Inc. 3:30 - 4:00 Greatbatch, Inc. (GB) Exelixis, Inc. (EXEL) KnowledgePoint360 Solutions, Inc. (MDRX) Holdings, Inc. (PTX) (TZYM) 3:50 Vertos Medical, Inc. Group, L.L.C. Patterson Companies Inc. ZIOPHARM Oncology, Integrated Diagnostics 4:00 - 4:30 Quidel Corp. (QDEL) Ardea Biosciences (RDEA) Cutera, Inc. (CUTR) 4:10 TyRx Pharma, Inc. (PDCO) Inc. (ZIOP) Incorporated Obagi Medical Products, Kips Bay Medical, Inc. 4:30 Precision Therapeutics, Avantis Medical Systems, 4:30 - 5:00 Incyte Corporation (INCY) Exactech Inc. (EXAC) Athersys, Inc. (ATHX) Inc. (OMPI) (KIPS) Inc. Inc.

The follow company is participating in one-on-one meetings only. Contact your Piper Jaffray representive if interested. Myriad Genetics, Inc. (MYGN)

Key: Biotech companies Speciality Pharma companies Med Tech companies Tools & Diagnostic companies Services companies China companies

PIPER JAFFRAY HEADQUARTERS ARE LOCATED IN MINNEAPOLIS, MINNESOTA, WITH OFFICES ACROSS THE U.S. AND IN LONDON, ZURICH AND HONG KONG. Piper Jaffray Companies is a leading, global middle market investment bank and asset management firm. Securities brokerage and investment banking services are offered in the United States through Piper Jaffray & Co., member SIPC and FINRA; in Europe through Piper Jaffray Ltd, authorised and regulated by the Financial Services Authority; and in Hong Kong through Piper Jaffray Asia Limited, Piper Jaffray Asia Securities Limited, and Piper Jaffray Asia Futures Limited, all of which are registered with the Hong Kong Securities and Futures Commission. Asset management products and services are offered through three separate investment advisory affiliates registered with the U.S. Securities and Exchange Commission: Advisory Research, Inc.; Fiduciary Asset Management Inc.; and Piper Jaffray Investment Management LLC.

© 2011 Piper Jaffray Companies. 800 Nicollet Mall, Minneapolis, Minnesota 55402-7020.

ScheduleforTuesday,November29,2011Page2of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York

Panel details for Tuesday, November 29, 2011:

10:00 - 11:00 a.m. Panel Discussion - Evolving Landscape for Treatment of MS

Co-Moderators: David Amsellem and Ian Somaiya, Senior Research Analysts, Piper Jaffray & Co.

Panelists: Stephen Krieger, MD, Assistant Professor in the Department of Neurology at Mount Sinai Medical Center in New York, NY Claire Riley, MD, Assistant Professor at the Yale School of Medicine at Yale University and attending neurologist at the Yale Neurology MS and Neuroimmunology Center in New Haven, CT

12:00 - 1:00 p.m. Panel Discussion - Washington Update: Provider and Payor Outlook for Medical Technology

Moderator: Thom Gunderson, Senior Research Analyst, Piper Jaffray & Co.

Panelists: John Kelliher, Managing Director, Marwood Group* Randel Richner, Founder & President, Neocure Group LLC Dr Barry Straube, Director, Marwood Group*

* a Rep t a h rese ost nta ed t tive able s fro for m t up he to 2 2:00 - 3:00 p.m. Mar ho woo urs Panel Discussion - China Healthcarde GMarket: Opportunities and Challenges foll rou owi p w ng t ill b he p e av ane Moderator: Hao Zhou, Senior Research Analyst, Pipera Jilaaffray & Co. l di ble scu for ssio netw n. ork Panelists: ing in th Friedhelm Blobel, Ph.D., CEO of SciClone Pharmaceuticals, Inc. (SCLN) e Re id R James Huang, Senior Managing Partner, KPCB China oom , 2n d fl oor

ScheduleforTuesday,November29,2011Page3of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York PIPER JAFFRAY HEADQUARTERS ARE LOCATED IN MINNEAPOLIS, MINNESOTA, WITH OFFICES ACROSS THE U.S. AND IN LONDON, ZURICH AND HONG KONG. Piper Jaffray Companies is a leading, global middle market investment bank and asset management firm. Securities brokerage and investment banking services are offered in the United States through Piper Jaffray & Co., member SIPC and FINRA; in Europe through Piper Jaffray Ltd, authorised and regulated by the Financial Services Authority; and in Hong Kong through Piper Jaffray Asia Limited, Piper Jaffray Asia Securities Limited, and Piper Jaffray Asia Futures Limited, all of which are registered with the Hong Kong Securities and Futures Commission. Asset management products and services are offered through three separate investment advisory affiliates registered with the U.S. Securities and Exchange Commission: Advisory Research, Inc.; Fiduciary Asset Management Inc.; and Piper Jaffray Investment Management LLC.

© 2011 Piper Jaffray Companies. 800 Nicollet Mall, Minneapolis, Minnesota 55402-7020.

ScheduleforTuesday,November29,2011Page4of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York Wednesday, Track One Track Two Track Three Track Four Track Five Track Six Track Seven November 30 Villard - 2nd floor Drawing Rm - 3rd floor Holmes 1 - 4th floor Holmes 2 - 4th floor Louis - 4th floor Kennedy 1 - 4th floor Kennedy 2 - 4th floor Piper Jaffray Senior Analyst Med Tech Breakfast Roundtable Public & Private Company 6:30 - 7:25 Hosted by: Kevin Ellich, Thom Gunderson, Matt Miksic, Bill Quirk, Brooks West and Hao Zhou Private Company Track Location: Louis Room, 4th floor, NY Palace. RSVP to your Piper Jaffray representative. Track Registration – Villard Foyer, 2nd Floor 7:30 Continental Breakfast – Reid Salon, 2nd Floor Public companies presenting in this track will be available for Questcor St. Jude Medical, Inc. Team Health Holdings, ISIS Pharmaceuticals Inc. networking in the Reid 8:00 - 8:30 Cepheid (CPHD) Pharmaceuticals, Inc. (STJ) Inc. (TMH) (ISIS) Room, 2nd floor at a (QCOR) hosted table for up to 2 hours following their presentation. TearLab Corporation 8:30 IDEV Technologies, Inc. (TEAR) 8:30 - 9:00 Inc. (AGN) Illumina, Inc. (ILMN) Cyberonics, Inc. (CYBX) Healthways, Inc. (HWAY) InTouch Technologies, 8:50 Inc.

Boston Scientific Cerner Corporation Arena Pharmaceuticals, Pathwork Diagnostics, 9:00 - 9:30 Akorn, Inc. (AKRX) MannKind Corp. (MNKD) 9:10 superDimension, Ltd. Corporation (BSX) (CERN) Inc. (ARNA) Inc.

Novadaq Technologies Integra LifeSciences 9:30 Acceleron Pharma, Inc. Watson Pharmaceuticals, Human Genome Computer Programs And Inc. (NVDTF) 9:30 - 10:00 Holdings Corporation Endologix Inc. (ELGX) Inc. (WPI) Sciences, Inc. (HGSI) Systems Inc. (CPSI) EnteroMedics, Inc. (IART) 9:50 Baxano, Inc. (ETRM) "CapSite 2011 Health Information Exchange PANEL: A Revolution in 10:00 - 10:30 AtriCure, Inc. (ATRC) MEDNAX, Inc. (MD) Nanosphere, Inc. (NSPH) (HIE) Study Findings" 10:10 PDI, Inc. (PDII) VBI Vaccines the treatment of Gino Johnson, SVP & GM Hepatitis C of CapSite Co-Moderators: SuperNova Diagnostics, Ian Somaiya and 10:30 NeoMend, Inc. Sinovac Biotech Ltd. Inc. 10:30 - 11:00 Ted Tenthoff Abaxis Inc. (ABAX) XenoPort, Inc. (XNPT) ICU Medical, Inc. (ICUI) (SVA) IRIS International Inc. 10:50 Metabolon, Inc. (IRIS)

UnitedHealth Group, Inc. Neurocrine Biosciences , Inc. Achillion Pharmaceuticals, IntegraMed America Inc. National Research Corp. 11:00 - 11:30 11:10 Signature Diagnostics AG (UNH) Inc. (NBIX) (JAZZ) Inc. (ACHN) (INMD) (NRCI)

Chelsea Therapeutics 11:30 LipoScience, Inc. , MWI Veterinary Supply, HeartWare International International Ltd (CHTP) 11:30 - 12:00 Tornier N.V. (TRNX) Inc. (ALXN) Inc. (MWIV) Inc. (HTWR)

11:50 Benefitfocus.com, Inc. 12:00 Visit the Reid Salon-2nd floor or Holmes Foyer-4th floor to pick-up a boxed lunch ScheduleforWednesday,November30,2011Page5of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York Wednesday, Track One Track Two Track Three Track Four Track Five Track Six Track Seven November 30 Villard - 2nd floor Drawing Rm - 3rd floor Holmes 1 - 4th floor Holmes 2 - 4th floor Louis - 4th floor Kennedy 1 - 4th floor Kennedy 2 - 4th floor

Advisory Board Co. Rigel Pharmaceuticals IntelliPharmaCeutics BG Medicine, Inc. STAAR Surgical Company 12:00 - 12:30 KEYNOTE: The Heart 12:10 Imprivata, Inc. (ABCO) (RIGL) International Inc. (IPCI) (BGMD) (STAA) Failure Continuum William Abraham, MD, Director, Div. of 12:30 PharmAthene, Inc. (PIP) HEALTHCAREfirst Inc. Cardiovasular Medicine, MAKO Surgical Corp Æterna Zentaris Inc. MedQuist Holdings, Inc. 12:30 - 1:00 MethylGene Inc. (MYG) The Ohio State University (MAKO) (AEZS) (MEDH) Accuray Incorporated 12:50 Healthland, Inc. (ARAY)

Amylin Pharmaceuticals, BioDelivery Sciences Shanghai Kinetic Medical 1:00 - 1:30 bioMerieux (BIM FP) ABIOMED, Inc. (ABMD) Inhibitex, Inc. (INHX) 1:10 TEI Biosciences, Inc. Inc. (AMLN) International, Inc. (BDSI) Co. Ltd.

Oxygen Biotherapeutics, 1:30 Intrexon Corporation Teva Pharmaceutical Mesoblast Limited (MSB Inc. (OXBT) 1:30 - 2:00 DynaVox Inc. (DVOX) Morphosys AG (MOR GR) TranS1 Inc. (TSON) Industries Limited (TEVA) AU) HMS Holdings Corp. 1:50 AngioChem Inc. (HMSY)

ViroPharma Incorporated Avanir Pharmaceuticals GenMark Diagnostics, Omeros Corporation Omthera 2:00 - 2:30 , Ltd. (COV) Medivation, Inc. (MDVN) 2:10 (VPHM) (AVNR) Inc. (GNMK) (OMER) Pharmaceuticals, Inc. CONMED Corporation Merit Medical Systems, Exact Sciences 2:30 Intersect ENT Inc. MEDISISS 2:30 - 3:00 POZEN Inc. (POZN) Curis Inc. (CRIS) (CNMD) Inc. (MMSI) Corporation (EXAS) 2:50 Heat Biologics, Inc. K2M Inc. Impax Laboratories, Inc. China Kanghui Holdings Fluidigm Corporation Dune Medical Devices 3:00 - 3:30 Tengion, Inc. (TNGN) 3:10 VertiFlex, Inc. (IPXL) (KH) (FLDM) Corporation RedBrick Health 3:30 OptiMedica Corporation Hansen Medical, Inc. Orthofix International NV SciClone Pharmaceuticals, InVivo Therapeutics Corporation 3:30 - 4:00 Insite Vision Inc. (INSV) (HNSN) (OFIX) Inc. (SCLN) Holdings Corp. (NVIV) iScience Interventional, Concert Pharmaceuticals, 3:50 Inc. Inc.

Complete Genomics, Inc. Company to be 4:00 - 4:30 CryoLife, Inc. (CRY) NuPathe, Inc. (PATH) Celsion Corp. (CLSN) 4:10 Intuity Medical, Inc. (GNOM) announced - Hao Zhou

Technical Research Discussion Craig Johnson, Sr Analyst, MELA Sciences, Inc. Sunshine Heart Inc. (SHC 4:30 - 5:00 Nuvo Research Inc. (NRI) Medgenics, Inc. (MEDG) Technical Research, (MELA) AU) Piper Jaffray & Co.

The follow company is participating in one-on-one meetings only. Contact your Piper Jaffray representive if interested. Myriad Genetics, Inc. (MYGN)

Key: Biotech companies Speciality Pharma companies ScheduleforWednesday,November30,2011Page6of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York Wednesday, Track One Track Two Track Three Track Four Track Five Track Six Track Seven November 30 Villard - 2nd floor Drawing Rm - 3rd floor Holmes 1 - 4th floor Holmes 2 - 4th floor Louis - 4th floor Kennedy 1 - 4th floor Kennedy 2 - 4th floor Med Tech companies Tools & Diagnostic companies Services companies China companies

PIPER JAFFRAY HEADQUARTERS ARE LOCATED IN MINNEAPOLIS, MINNESOTA, WITH OFFICES ACROSS THE U.S. AND IN LONDON, ZURICH AND HONG KONG. Piper Jaffray Companies is a leading, global middle market investment bank and asset management firm. Securities brokerage and investment banking services are offered in the United States through Piper Jaffray & Co., member SIPC and FINRA; in Europe through Piper Jaffray Ltd, authorised and regulated by the Financial Services Authority; and in Hong Kong through Piper Jaffray Asia Limited, Piper Jaffray Asia Securities Limited, and Piper Jaffray Asia Futures Limited, all of which are registered with the Hong Kong Securities and Futures Commission. Asset management products and services are offered through three separate investment advisory affiliates registered with the U.S. Securities and Exchange Commission: Advisory Research, Inc.; Fiduciary Asset Management Inc.; and Piper Jaffray Investment Management LLC.

© 2011 Piper Jaffray Companies. 800 Nicollet Mall, Minneapolis, Minnesota 55402-7020.

ScheduleforWednesday,November30,2011Page7of8 Schedule as of: November 23, 2011 Schedule is subject to change. 23rd Annual Piper Jaffray Health Care Conference Tuesday, November 29 - Wednesday, November 30, 2011 New York Palace Hotel, New York

Panel details for Wednesday, November 30, 2011:

10:00 - 11:00 a.m. Panel Discussion - A Revolution in the treatment of Hepatitis C

Co-Moderators: Ian Somaiya and Ted Tenthoff, Senior Research Analysts, Piper Jaffray & Co.

Panelists: Melissa Palmer, MD, Clinical Professor; Medical Dir - NYU Hepatology Associates Plainview, NYU Gastroenterology Associates Andrew Pearlman, President & CEO, Medgenics, Inc. Sam Waksal, PhD, CEO, Kadmon Pharmaceuticals LLC Steve Worland, CEO & Director, Anadys Pharmaceuticals, Inc.

PIPER JAFFRAY HEADQUARTERS ARE LOCATED IN MINNEAPOLIS, MINNESOTA, WITH OFFICES ACROSS THE U.S. AND IN LONDON, ZURICH AND HONG KONG. Piper Jaffray Companies is a leading, global middle market investment bank and asset management firm. Securities brokerage and investment banking services are offered in the United States through Piper Jaffray & Co., member SIPC and FINRA; in Europe through Piper Jaffray Ltd, authorised and regulated by the Financial Services Authority; and in Hong Kong through Piper Jaffray Asia Limited, Piper Jaffray Asia Securities Limited, and Piper Jaffray Asia Futures Limited, all of which are registered with the Hong Kong Securities and Futures Commission. Asset management products and services are offered through three separate investment advisory affiliates registered with the U.S. Securities and Exchange Commission: Advisory Research, Inc.; Fiduciary Asset Management Inc.; and Piper Jaffray Investment Management LLC.

© 2011 Piper Jaffray Companies. 800 Nicollet Mall, Minneapolis, Minnesota 55402-7020.

ScheduleforWednesday,November30,2011Page8of8