ICBDD 14 Annual Symposium Brochure.Pdf
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FOURTEENTH A N N U A L S Y M P O S I U M Institute of Chemical Biology & Drug Discovery “Frontiers of Chemical Biology and Drug Discovery: Nucleic Acid-Based Medicine” ........................................................................................................................ Thursday, October 8, 2020 Via Zoom ......................................................................................................................... Distinguished Speakers Dr. George Calin, The University of Texas MD Anderson Center Dr. Richard Gregory, Harvard University Dr. Lin He, University of California, Berkeley Dr. Jingfang Ju, Stony Brook University Dr. Adrian Krainer, Cold Spring Harbor Laboratory Dr. Vivek Mittal, Weill Cornell Medicine Dr. Jennifer Petter, Arrakis Therapeutics Poster Sessions Poster Awards Stony Brook University/SUNY is an affirmative action, equal opportunity educator and employer. 10090247 From the Director ICB&DD’s History and Mission The primary objective of the he ICB&DD was established in 2004 with Stony Institute of Chemical Biology & Brook University’s institutional support as well Drug Discovery (ICB&DD) is to as the NYSTAR Faculty Development Award. One establish and sustain a world- of ICB&DD’s strengths is that it has been founded by class “Center of Excellence” in reorganizing existing exceptional talents on campus, and chemical biology and drug thus the core of the institute is a well proven entity with discovery at Stony Brook University. The rapid and an excellent track record. ICB&DD is open to a wide range impressive advancements in of collaborative research programs with pharmaceutical chemical biology during the and biotechnology industrial firms. Members of ICB&DD last decade have clearly are from the departments of Chemistry, Pharmacological demonstrated that solutions for a vast majority of Sciences, Medicine, Molecular Genetics and medical problems rely on the understanding of the Microbiology, Biochemistry and Cellular Biology, molecular basis of diseases, therapeutic targets, drug Physiology and Biophysics, Applied Mathematics and actions, and drug resistance. ICB&DD promotes highly Statistics, Oral Biology and Pathology, Cancer Center, productive interdisciplinary and collaborative research Center for Structural Biology, Center for Infectious among chemists, biologists, medicinal chemists, pharmacologists, and physicians to tackle major Diseases, and Brookhaven National Laboratory. In biomedical problems to find solutions including the addition, ICB&DD has two core laboratories located in the discovery of novel therapeutic drugs and innovative Chemistry Building: Analytical Instrumentation diagnostic tools. Laboratory and Discovery Chemistry Laboratory. Iwao Ojima, Director, Institute of Chemical Biology ICB&DD has three major programs: Structural and & Drug Discovery Computational Biology Program, Infectious Diseases Dr. Iwao Ojima received his B.S., M.S., and Ph.D. (1973) degrees Research Program, and Cancer Research Program. In from the University of Tokyo, Japan. He joined the Sagami Institute addition, ICB&DD has two strategic Research of Chemical Research and held a position of Senior Research Laboratories on Cancer Stem Cell Research and Anti- Fellow until 1983. He joined the faculty at the Department of inflammatory Research. ICB&DD collaborates with the Chemistry, State University of New York at Stony Brook first as Stony Brook University Cancer Center to develop a Associate Professor (1983), was promoted to Professor (1984), Cancer Therapeutics Program. ICB&DD integrates the Leading Professor (1991), and then to Distinguished Professor existing strengths at Stony Brook University in the basic (1995). He served as the Department Chairman from 1997 to 2003. He has been serving as the founding Director for the Institute of medical sciences as well as medicinal chemistry and Chemical Biology and Drug Discovery (ICB&DD) from 2003. He brings in complementary expertise from outside to has a wide range of research interests in synthetic organic and explore drug discovery and development. At present, medicinal chemistry as well as chemical biology, including ICB&DD focuses on drug discovery in therapeutics for discovery and development of anticancer agents, antimicrobials, cancer, infectious diseases, neurodegenerative diseases and targeted drug delivery systems. His awards and honors include and inflammation. Arthur C. Cope Scholar Award (1994), E. B. Hershberg Award for Important Discoveries of Medicinally Active Substances (2001), the Medicinal Chemistry Hall of Fame (2006), ACS Award for Through ICB&DD connections, a number of collaborative Creative Work in Fluorine Chemistry (2013), and E. Guenther research teams have been created and research Award in the Chemistry of Natural Products (2019) from the proposals have successfully acquired grants from NIH and American Chemical Society; the Chemical Society of Japan Award other funding agencies. (Total grant funding > 61M). (1999); Outstanding Inventor Award (2002) from the Research Currently, there are 11 ongoing ICB&DD-designated Foundation of the State University of New York; Elected Fellow of projects (Total funding: $21M). J. S. Guggenheim Memorial Foundation, the American Association for the Advancement of Science, the New York Academy of Sciences, the American Chemical Society and the National Academy of Inventors. ICB&DD 14th Annual Symposium Thursday, October 8, 2020 via Zoom Join Zoom Meeting https://stonybrook.zoom.us/j/92056653486?pwd=UlRIb00weWFSZzFFSEVjZFRGZy85UT09 Meeting ID: 920 5665 3486 Passcode: 300041 “Frontiers of Chemical Biology and Drug Discovery: Nucleic Acid-Based Medicine” 9:15 am to 9:30 am Opening Remarks Dr. Jingfang Ju, Professor of Pathology, Stony Brook University Renaissance School of Medicine. Chair, Symposium Organizing Committee Dr. Kenneth Kaushansky, Dean, Stony Brook University Renaissance School of Medicine Dr. Iwao Ojima, Distinguished Professor and Director, Institute of Chemical Biology and Drug Discovery, Stony Brook University 9:30 am to 10:15 am Moderator: Dr. Chia-Hsin (Lori) Chan Dr. George A. Calin, Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Center “About Chomsky, Non-codingRNAs and Cancer Therapy” 10:15 am to 11:00 am Moderator: Dr. Jingfang Ju Dr. Richard I. Gregory, Professor and Chairman, Department of Pediatrics Stem Cell Biology, Harvard Medical School “Role of the Epitranscriptome in Gene Regulation and Cancer” 11:00 am to 11:45 am Moderator: Martin Kaczocha Dr. Jingfang Ju, Professor, Department of Pathology, Stony Brook University Renaissance School of Medicine “Development of miRNA Based Platform Technology for Cancer Therapeutics” 11:45 am to 1:00 pm Lunch and Poster Session via Zoom 1:00 pm to 1:45 pm Moderator: Adam Rosebrock Dr. Lin He, Professor, Department of Molecular & Cell Biology, University of California, Berkeley “Friends or Foes, Retrotransposons in Mammalian Preimplantation Development” 1:45 pm to 2:30 pm Moderator: Elizabeth Boon Dr. Adrian Krainer, St. Giles Foundation Professor, Cold Spring Harbor Laboratory (CSHL) and Deputy Director of Research at CSHL Cancer Center “From Base Pairs to Bedside: Antisense Modulation of RNA Splicing” 2:30 pm to 3:30 pm Student Poster Session via Zoom 3:30 pm to 4:15 pm Moderator: John Haley Dr. Vivek Mittal, Professor of Cardiothoracic Surgery and Director, Neuberger Berman Foundation Lung Cancer Laboratory, Weill Cornell Medicine “Metastasis Suppressor miRNAs in Triple Negative Breast Cancer” 4:15 pm to 5:00 pm Moderator: Peter Tonge Dr. Jennifer C. Petter, Founder and CSO, Arrakis Therapeutics “Drugging RNA with Small Molecules” 5:00 pm to 5:05 pm Closing Remarks: Dr. Martin Kaczhocha 5:05 pm to 5:10 pm Announcement of Poster Awards: Dr. Chia-Hsin (Lori) Chan 5:10 pm to 5:30 pm Short Presentations by the Award Winners Speakers Dr. George A. Calin received both his Dr. Richard I. Gregory is a Professor in M.D. and Ph.D. degrees at Carol Davila the Department of Biological Chemistry University of Medicine in Bucharest, and Molecular Pharmacology at Harvard Romania. After working in cytogenetics Medical School, and the Department of as an undergraduate student with Dr. Pediatrics Stem Cell Biology Chair. He is Dragos Stefanescu in Bucharest, he principal investigator in the Stem Cell completed a cancer genomics training in Program, Division of Hematology/ Dr. Massimo Negrini’s laboratory at the Oncology at Boston Children’s Hospital. University of Ferrara, Italy. In 2000 he He is also co-Director and executive became a postdoctoral fellow at Kimmel committee member of the Harvard Cancer Center in Philadelphia, PA, and while working in Dr. Initiative for RNA Medicine (HIRM), faculty member of the Carlo Croce’s laboratory, Dr. Calin was the first to discover the Dana–Farber/Harvard Cancer Center, and principal faculty link between microRNAs and human cancers, a finding member of The Harvard Stem Cell Institute (HSCI). The considered a milestone in microRNA research history. He is laboratory’s research on RNA regulatory mechanisms has led to presently a Professor in the Experimental Therapeutics and several breakthrough findings and is funded in part by an Leukemia Departments at M. D. Anderson Cancer Center in Outstanding Investigator R35 award from the National Cancer Houston and studies the roles of microRNAs and other non- Institute. Current research is focused on RNA modifications, coding RNAs in cancer initiation and progression and