Rabbit Anti-Human TJP2 (Phospho-Tyr1118) Polyclonal Antibody (CABT-L4155) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Rabbit Anti-Human TJP2 (Phospho-Tyr1118) polyclonal antibody (CABT-L4155) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview This antibody detects endogenous levels of ZO-2 only when phosphorylated at Tyr1118.

Specificity Target Modification: Phospho. Modification Sites: Human: Y1118; Mouse: Y1095; Rat: Y1093

Target Human ZO-2 (Phospho-Tyr1118)

Immunogen The antiserum was produced against synthesized phospho-peptide derived from human ZO-2 around the phosphorylation site of Tyr1118.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse, Rat

Purification Affinity Purified

Conjugate Unconjugated

Applications WB, ELISA

Molecular Weight 133 kDa

Preparation The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Format Liquid

Concentration Lot specific

Buffer Rabbit IgG in PBS (Phospho-without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.

Preservative 0.02% Sodium Azide

Storage Stable at -20°C for at least 1 year.

Ship Wet ice

Warnings For research use only.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Keywords TJP2;tight junction protein 2;ZO2;X104;PFIC4;DFNA51;DUP9q21.11;C9DUPq21.11;tight junction protein ZO-2;zona occludens 2;zonula occludens protein 2;Friedreich ataxia region gene X104 (tight junction protein ZO-2);

GENE INFORMATION

Gene Name TJP2 tight junction protein 2 [ Homo sapiens (human) ]

Official Symbol TJP2

Synonyms Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2

Entrez Gene ID 9414

UniProt ID Q9UDY2

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]