34TH GENERAL ANNUAL MEETING OF THE BELGIAN HEMATOLOGY SOCIETY

Final Programme 1-2 FEBRUARY 2019 Dolce La Hulpe,

www.bhs.be SCIENTIFIC COMMITTEE - STRIVING TO OUTSMART BHS BOARD MEMBERS AND FUNCTIONS CANCER. TOGETHER. Nathalie Meuleman President Marie-Christiane Vekemans Vice President Benjamin Bailly Councilor Educational affairs Samantha Benghiat Councilor Educational affairs Dimitri Breems Councilor Scientific affairs/Patient affairs Kristel Buvé Councilor Clinical affairs Barbara Cauwelier Treasurer Anne De Weweire Councilor Scientific affairs Chantal Doyen Councilor Patient affairs Ann Janssens Webmaster Veerle Labarque Pediatric liaison Dominiek Mazure Secretary Sophie Servais Councilor Educational affairs Cécile Springael Councilor Committees Ivan Van Riet Councilor Scientific affairs/Board representative JACIE committee Anke Verlinden Councilor Clinical affairs/Board representative Nurses committee

At AbbVie, we build bonds with haematologists, oncologists, patients, payers, advocacy groups, health authorities, and other pharmaceutical BHS Society Management Office companies, because we know that advancing the science of this Congress Care devastating disease is not something that one person, or even one P.O. Box 440 company, can do alone. 5201 AK ’s-Hertogenbosch The Netherlands Together we can conduct research that deepens our understanding of the [email protected] disease and its pathways, to ultimately develop new molecules that make www.congresscare.com a transformational improvement in cancer care.

people. passion. possibilities. www.bhs.be 3 AbbVie sa/nv – BE-ONCO-180003 (v1.0) – Jan 19

ABV-Onoc Ad A5 (SH 9396 + SH 10209).indd 1 15/01/19 15:08

www.bhs.be www.bhs.be

4 5

L. Buedts L.

a joint KU and LYSA study on circulating cell-free DNA cell-free circulating on study LYSA and Leuven KU joint a

Unraveling the landscape of copy number aberrations in Hodgkin lymphoma: lymphoma: Hodgkin in aberrations number copy of landscape the Unraveling 13:45

A. De Becker De A.

hematological malignancies hematological

after myeloablative or nonmyeloablative conditioning in patients with with patients in conditioning nonmyeloablative or myeloablative after

transplantation with coinfusion of third-party mesenchymal stromal cells cells stromal mesenchymal third-party of coinfusion with transplantation

A pilot study to assess the feasibility of unrelated umbilical cord blood blood cord umbilical unrelated of feasibility the assess to study pilot A 13:30

Chairs: Dimitri Breems & Chantal Doyen Chantal & Breems Dimitri Chairs:

Selected oral abstracts oral Selected 15.00 - 13.30

Lunch and Commented Poster Walk 1 Walk Poster Commented and Lunch 13.30 - 12.30

Dr. Reuben Benjamin, King’s College , London Hospital, College King’s Benjamin, Reuben Dr.

lymphoma

Patient management before, during and after CAR-T treatment in aggressive aggressive in treatment CAR-T after and during before, management Patient 12.00

Prof. Catherine Thieblemont, Hôpitaux Universitaires Saint-Louis, Paris Saint-Louis, Universitaires Hôpitaux Thieblemont, Catherine Prof. 

Clinical overview of anti-CD19 CAR-T cell therapy in DLBCL in therapy cell CAR-T anti-CD19 of overview Clinical 11.30

Chair: Prof. Peter Vandenberghe, UZ Leuven UZ Vandenberghe, Peter Prof. Chair:

President BHS BHS President

“CAR-T cell approaches in Aggressive B Cell Lymphoma” Cell B Aggressive in approaches cell “CAR-T

Nathalie Meuleman Nathalie

Gilead by sponsored 1 session Satellite 12.30 - 11.30

On behalf of the board, the of behalf On

Prof. Julien Haroche, Hôpital de la Pitié Salpêtrière, Paris, France Paris, Salpêtrière, Pitié la de Hôpital Haroche, Julien Prof.

Histiocytoses: inflammatory or neoplastic diseases? neoplastic or inflammatory Histiocytoses:

I wish you an inspiring congress! congress! inspiring an you wish I

Chairs: Marie-Christiane Vekemans & Dominiek Mazure Dominiek & Vekemans Marie-Christiane Chairs:

Special lecture 1: 1: lecture Special 11.30 - 11.00

great enthusiasm that we will welcome them once again on Friday. on again once them welcome will we that enthusiasm great

For several years the “Nurse symposium” has become a must at our meeting and it is with is it and meeting our at must a become has symposium” “Nurse the years several For

Coffee break break Coffee 11.00 - 10.30

the commented poster walk and the awards for young researchers. young for awards the and walk poster commented the

Prof. Laure Bindels, Louvain Drug Research Institute, Brussels Brussels Institute, Research Drug Louvain Bindels, Laure Prof.

Lecture”. Research is once again highlighted during the selected oral presentations, presentations, oral selected the during highlighted again once is Research Lecture”.

The gut microbiota gut The 10.00

to cure chronic lymphocytic leukemia by Professor Michael Hallek during the “Pierre Stryckmans Stryckmans “Pierre the during Hallek Michael Professor by leukemia lymphocytic chronic cure to

Prof. Thierry VandenDriessche, Vrije Universiteit Brussel, Brussels Brussels Brussel, Universiteit Vrije VandenDriessche, Thierry Prof.

histiocytosis, Acute myeloid leukemia, pregnancy and cancer and the discussion of the possibility possibility the of discussion the and cancer and pregnancy leukemia, myeloid Acute histiocytosis,

Gene therapy for haemophilia: recent preclinical and clinical advances advances clinical and preclinical recent haemophilia: for therapy Gene 09.30

We will also taste of high quality clinical topics as multiple myeloma and belgian guidelines, guidelines, belgian and myeloma multiple as topics clinical quality high of taste also will We

Chairs: Barbara Cauwelier & Ivan Van Riet Van Ivan & Cauwelier Barbara Chairs:

discussed: gene therapy in haemophilia and the impact of gut microbiota. gut of impact the and haemophilia in therapy gene discussed:

Advances in laboratory technology technology laboratory in Advances 10.30 - 09.30

In the third edition of the “Advances in laboratory technology” session, two major topics will be be will topics major two session, technology” laboratory in “Advances the of edition third the In

presentation on ethical implications of incidental findings in next generation sequencing. generation next in findings incidental of implications ethical on presentation

Prof. Marie-Christiane Vekemans, Cliniques universitaires Saint Luc (UCL), Brussels (UCL), Luc Saint universitaires Cliniques Vekemans, Marie-Christiane  Prof.

This year, we will continue the success story of the “Ethics and Economy” session with a special special a with session Economy” and “Ethics the of story success the continue will we year, This

Belgian treatment guidelines 2019 for multiple myeloma multiple for 2019 guidelines treatment Belgian

Meuleman Nathalie & Doyen Chantal Chairs:

developments in the field. the in developments

Highlight 1: 1: Highlight 09.30 - 09.00

approach, current recommendations for the treatment of hematologic diseases as well as new new as well as diseases hematologic of treatment the for recommendations current approach,

We have selected several high-level scientific presentations which will cover the diagnostic diagnostic the cover will which presentations scientific high-level several selected have We

Prof. Nathalie Meuleman, President BHS BHS President Meuleman, Nathalie Prof.

Welcome Welcome 09.00 - 08.45

34 the to Welcome . Hulpe La Dolce in BHS the of Meeting Annual General

th

Registration Registration 08.00 Dear colleagues, Dear

FRIDAY 1 FEBRUARY 2019 2019 FEBRUARY 1 FRIDAY

PROGRAM GENERAL ANNUAL MEETING MEETING ANNUAL GENERAL PROGRAM INTRODUCTION Canopée Auditorium Canopée

www.bhs.be www.bhs.be 6

7

Congress dinner (additional registration necessary) registration (additional dinner Congress 19.00

Reception 19.00 - 18.00

Prof. Michael Hallek, University Hospital Cologne, Köln, Germany Germany Köln, Cologne, Hospital University Hallek, Michael Prof.

Is there a curing menu for chronic lymphocytic leukemia? lymphocytic chronic for menu curing a there Is

Introduction by: Prof. Ann Janssens, UZ Leuven, Leuven Leuven, UZ Janssens, Ann Prof. by: Introduction

Chairs: Nathalie Meuleman & Marie-Chrisitane Vekemans Marie-Chrisitane & Meuleman Nathalie Chairs:

Pierre Stryckmans Lecture: Stryckmans Pierre 18.00 - 17.00

Congress dinner (additional registration necessary) registration (additional dinner Congress 19.00

Presentation by Prof. Pascal Borry, UZ Leuven, Leuven Leuven Leuven, UZ Borry, Pascal Prof. by Presentation

Introduction by Prof. Veerle Labarque, UZ Leuven, Leuven Leuven, UZ Labarque, Veerle Prof. by Introduction

Reception + Commented Poster Walk 2 Walk Poster Commented + Reception 19.00 - 18.00

Ethic, legal and social implications of next generation sequencing generation next of implications social and legal  Ethic,

Ethics and Economy: Economy: and Ethics 16.00

Prof. Michael Hallek, University Hospital Cologne, Köln, Germany Germany Köln, Cologne, Hospital University Hallek, Michael Prof. Canopée Auditorium Canopée

Is there a curing menu for chronic lymphocytic leukemia? lymphocytic chronic for menu curing a there Is

Coffee break Coffee 16.00 - 15.30 Introduction by: Prof. Ann Janssens, UZ Leuven, Leuven Leuven, UZ Janssens, Ann Prof. by: Introduction

Chairs: Nathalie Meuleman & Marie-Chrisitane Vekemans Marie-Chrisitane & Meuleman Nathalie Chairs:

Dr. Anne Sonet, CHU UCL (Godinne), Yvoir (Godinne), Namur UCL CHU Sonet, Anne Dr.

Pierre Stryckmans Lecture: Lecture: Stryckmans Pierre 18.00 - 17.00 The use of antifungal drugs in immunocompromised patients immunocompromised in drugs antifungal of use The 14.30

Dr. Toine Mercier, UZ Leuven, Leuven Leuven, UZ Mercier, Toine Dr. Prof. Pascal Borry, UZ Leuven, Leuven Leuven, UZ Borry, Pascal Prof. by Presentation 

Fungal infections: who? what? where? and why? and where? what? who? infections: Fungal 14.30

Prof. Veerle Labarque, UZ Leuven, Leuven Leuven Leuven, UZ Labarque, Veerle Prof. by Introduction 

Ethic, legal and social implications of next generation sequencing generation next of implications social and legal Ethic, Prof. Marie-Madeleine Dolmans, Cliniques universitaires Saint Luc (UCL), Brussels (UCL), Luc Saint universitaires Cliniques Dolmans, Marie-Madeleine Prof.

Chairs: Kristel Buvé & Samantha Benghiat Samantha & Buvé Kristel Chairs: Fertility preservation before cancer treatment cancer before preservation Fertility 14.00

Ethics and Economy: Economy: and Ethics 17.00 - 16.00

Anneleen Vanhellemont, UZ Leuven, Leuven Leuven, UZ Vanhellemont, Anneleen

Adherence to oral anticancer drugs anticancer oral to Adherence 13.30

Coffee break break Coffee 16.00 - 15.40

Lunch 13.30 - 12.30

Prof. Ann Janssens, webmaster BHS webmaster Janssens, Ann Prof.

new? something Website: 15.40 - 15.30 Dr. Dominik Selleslag, AZ St. Jan Brugge, Brugge Brugge, Jan St. AZ Selleslag, Dominik Dr.

Haploidentical stem cell transplantation: state of the art anno 2019 anno art the of state transplantation: cell stem Haploidentical 11.45

the Netherlands the

Michele Landeloos, UZ Leuven, Leuven Leuven, UZ Landeloos, Michele

Prof. Gert Ossenkoppele, Amsterdam University Medical Center, Amsterdam, Amsterdam, Center, Medical University Amsterdam Ossenkoppele, Gert  Prof.

Interprofessional teamwork: a necessity? a teamwork: Interprofessional 11.30

Future in acute myeloid leukemia leukemia myeloid acute in Future

Bailly Benjamin & Breems Dimitri Chairs:

Prof. Barbara De Moerloose, UZ Gent, Gent Gent, UZ Moerloose, De Barbara Prof.

leukemia Special lecture 2 lecture Special 15.30 - 15.00

Hurdies and challenges of CART-therapy in children with acute lymphoblastic lymphoblastic acute with children in CART-therapy of challenges and Hurdies 11.00

M. Colard M.

Coffee break break Coffee 11.00 - 10.30

Erythropoietin modulates red blood cells elimination cells blood red modulates Erythropoietin 14:45

Johan De Munter/ Marijke Quaghebeur, UZ Gent, Gent Gent, UZ Quaghebeur, Marijke Munter/ De Johan E. Bollaert E.

Adolescents/young adults and their caregiver on the onco-hematology ward onco-hematology the on caregiver their and adults Adolescents/young 09.45 induced by daunorubicin in acute myeloid leukemia cell lines. cell leukemia myeloid acute in daunorubicin by induced

Overexpression of miR-15a-5p confers chemoresistance by inhibiting autophagy autophagy inhibiting by chemoresistance confers miR-15a-5p of Overexpression 14:30

Patrick Desmet, the patient perspective patient the Desmet, Patrick

L. Fenwarth Fenwarth L. Wanting to have children and being a haemophilia patient haemophilia a being and children have to Wanting

Results from the Randomized ALFA-0702 Study ALFA-0702 Randomized the from Results Noémie Colasuonno, the patient perspective patient the Colasuonno, Noémie

with Acute Myeloid Leukemia with Complex or Micro-Complex Karyotype: Karyotype: Micro-Complex or Complex with Leukemia Myeloid Acute with Living with haemophilia: from toddler till young adult woman! adult young till toddler from haemophilia: with Living 09.00

Clofarabine-Based Consolidation Improves Relapse-Free Survival of Patients Patients of Survival Relapse-Free Improves Consolidation Clofarabine-Based 14:15

Martine Heylens Chair Nurses committee Nurses Chair Heylens Martine

F. Gelders F.

Welcome 09.00 - 08.45

lymphoproliferative disorder lymphoproliferative

Renal allograft function following treatment of post-transplant post-transplant of treatment following function allograft Renal 14:00 Registration 08.00

2019 FEBRUARY 1 FRIDAY

PROGRAM NURSE MEETING MEETING NURSE PROGRAM Baobab Auditorium Baobab

www.bhs.be www.bhs.be

8 9

Simultaneous translation will be available for the Nurse meeting. Nurse the for available be will translation Simultaneous

TRANSLATION

meeting of the Belgian Hematology Society. Hematology Belgian the of meeting

A technical and pharmaceutical exhibition will be organized in conjunction with the annual annual the with conjunction in organized be will exhibition pharmaceutical and technical A

EXHIBITION

Ethics and Economy. and Ethics

Election results and Closing Remarks Remarks Closing and results Election 13.00 Accreditation for the General Annual Meeting is pending with specific accreditation for for accreditation specific with pending is Meeting Annual General the for Accreditation

ACCREDITATION

Presentations projects PACE Awards 2018 Awards PACE projects Presentations

Presentations projects PACE Awards 2017 Awards PACE projects Presentations before the end of January. of end the before

Awards for best oral and poster presentations presentations poster and oral best for Awards 13.00 - 12.30 Only regular members are allowed to vote. Information on e-voting will be send to members members to send be will e-voting on Information vote. to allowed are members regular Only

ELECTIONS OF BOARD MEMBERS BOARD OF ELECTIONS

Dr. Pauline Brice, Hôpitaux Universitaires Saint-Louis, Lariboisière, Paris, France Paris, Lariboisière, Saint-Louis, Universitaires Hôpitaux Brice, Pauline Dr.

Managing Hodgkin lymphoma in transplantation ineligible patients patients ineligible transplantation in lymphoma Hodgkin Managing 12.00 All refunds will be made after the congress. the after made be will refunds All

Dr. Rakesh Popat, University College London Hospital, London, United Kingdom United London, Hospital, London College University Popat, Rakesh Dr. administration costs. After this date no refunds will be given. be will refunds no date this After costs. administration

Therapeutic options for penta-refractory and high risk multiple myeloma patients. myeloma multiple risk high and penta-refractory for options Therapeutic 11.30 Cancellations made before 8 January 2019 will be refunded less 35 euro to cover cover to euro 35 less refunded be will 2019 January 8 before made Cancellations

Satellite session 3 sponsored by Takeda by sponsored 3 session Satellite 12.30 - 11.30 Cancellations and refund requests must be submitted in writing to the congress secretariat. secretariat. congress the to writing in submitted be must requests refund and Cancellations

CANCELLATION

Coffee break break Coffee 11.30 - 11.00

Payment of your 2018 membership fee should be settled before January 1st, 2019! 1st, January before settled be should fee membership 2018 your of Payment

s Netherland the Amsterdam, Ziekenhuis, Leeuwenhoek entitled to register for the GAM at the discounted member registration fee. fee. registration member discounted the at GAM the for register to entitled

Prof. Frederik Amant, UZ Leuven, Leuven, Belgium and Antoni Van Van Antoni and Belgium Leuven, Leuven, UZ Amant, Frederik  Prof. Only approved 2018 BHS members (and membership applications before December 1st) are are 1st) December before applications membership (and members BHS 2018 approved Only

efficacious? PLEASE NOTE PLEASE

Cancer treatment for haematological malignancies during pregnancy: safe? safe? pregnancy: during malignancies haematological for treatment Cancer 10.30

Prof. Michel De Vos, UZ Brussel, Brussels Brussel, UZ Vos, De Michel Prof. * MD hematologists, MD specialists, Senior scientists, MD trainees, PhD students PhD trainees, MD scientists, Senior specialists, MD hematologists, MD *

 offered? be can

Fertility preservation for young patients with cancer: who is at risk and what what and risk at is who cancer: with patients young for preservation Fertility 10.00 Non-member 55,00 EUR 45,00 EUR

Chairs: Veerle Labarque & Sophie Servais Sophie & Labarque Veerle Chairs: member associate BHS 40,00 EUR 35,00 EUR

Highlight 2: Pregnancy and Cancer and Pregnancy 2: Highlight 11.00 - 10.00 Nurse Meeting Nurse

Foundation Trust, Bristol, United Kingdom United Bristol, Trust, Foundation meeting* GAM Non-member 300,00 300,00 EUR 250,00 EUR

Prof. David Marks, University Bristol, National Health Service Service Health National Bristol, Hospitals University Marks, David Prof.  students) PhD trainees, (MD member junior BHS 100,00 100,00 EUR 75,00 EUR

lymphoblastic leukemia with an antibody-drug conjugate antibody-drug an with leukemia lymphoblastic scientists) Senior specialists, MD 150,00 150,00 EUR 125,00 EUR

Management considerations in treating relapsed or refractory acute acute refractory or relapsed treating in considerations Management 09.30 BHS member (MD hematologists, hematologists, (MD member BHS

Saint-Quentin, Le Chesnay, France Chesnay, Le Saint-Quentin, General Annual Meeting Annual General

Prof. Sylvie Castaigne, Centre Hospitalier de Versailles, Université de Versailles Versailles de Université Versailles, de Hospitalier Centre Castaigne, Sylvie  Prof. FEES and on-site on-site and 22/12/2018

Moving beyond 7+3 for treatment of first line acute myeloid leukemia myeloid acute line first of treatment for 7+3 beyond Moving 09.00

Before After 22/12/2018 After

Chair: Prof. Johan Maertens, UZ Leuven UZ Maertens, Johan Prof. Chair:

Satellite session 2 sponsored by Pfizer Pfizer by sponsored 2 session Satellite 10.00 - 09.00 REGISTRATION FOR THE GENERAL ANNUAL MEETING 2019 MEETING ANNUAL GENERAL THE FOR REGISTRATION

GENERAL ASSEMBLY - (access for BHS members only) members BHS for (access - ASSEMBLY GENERAL 09.00 - 08.30 Registration via website www.BHS.be website via Registration

SATURDAY 2 FEBRUARY 2018 2018 FEBRUARY 2 SATURDAY

GENERAL INFORMATION GENERAL MEETING ANNUAL GENERAL PROGRAM Canopée Auditorium Canopée

www.bhs.be www.bhs.be

10 11

Simultaneous translation will be available for the Nurse meeting. Nurse the for available be will translation Simultaneous

TRANSLATION

meeting of the Belgian Hematology Society. Hematology Belgian the of meeting

A technical and pharmaceutical exhibition will be organized in conjunction with the annual annual the with conjunction in organized be will exhibition pharmaceutical and technical A

EXHIBITION

and Economy. and

Accreditation for the General Annual Meeting is pending with specific accreditation for Ethics Ethics for accreditation specific with pending is Meeting Annual General the for Accreditation

ACCREDITATION

before the end of January. of end the before

Only regular members are allowed to vote. Information on e-voting will be send to members members to send be will e-voting on Information vote. to allowed are members regular Only

ELECTIONS OF BOARD MEMBERS BOARD OF ELECTIONS

All refunds will be made after the congress. the after made be will refunds All

costs. After this date no refunds will be given. be will refunds no date this After costs.

Cancellations made before 8 January 2019 will be refunded less 35 euro to cover administration administration cover to euro 35 less refunded be will 2019 January 8 before made Cancellations

Cancellations and refund requests must be submitted in writing to the congress secretariat. secretariat. congress the to writing in submitted be must requests refund and Cancellations

CANCELLATION

Payment of your 2018 membership fee should be settled before January 1st, 2019! 1st, January before settled be should fee membership 2018 your of Payment

entitled to register for the GAM at the discounted member registration fee. fee. registration member discounted the at GAM the for register to entitled

Only approved 2018 BHS members (and membership applications before December 1st) are are 1st) December before applications membership (and members BHS 2018 approved Only

PLEASE NOTE PLEASE

* MD hematologists, MD specialists, Senior scientists, MD trainees, PhD students PhD trainees, MD scientists, Senior specialists, MD hematologists, MD *

THE BHS GAM 2019 APP IS SPONSORED BY: SPONSORED IS APP 2019 GAM BHS THE

Non-member 55,00 EUR 45,00 EUR

member associate BHS 40,00 EUR 35,00 EUR

Nurse Meeting Nurse

meeting* GAM Non-member 300,00 300,00 EUR 250,00 EUR

students) PhD trainees, (MD member junior BHS 100,00 100,00 EUR 75,00 EUR

scientists) Senior specialists, MD 150,00 150,00 EUR 125,00 EUR

BHS member (MD hematologists, hematologists, (MD member BHS

General Annual Meeting Annual General

3. In case the App is already installed on your mobile device, please install the update the install please device, mobile your on installed already is App the case In 3. FEES and on-site on-site and 22/12/2018

2. After completion: install BHS GAM 2019 into the BHS Events App Events BHS the into 2019 GAM BHS install completion: After 2. Before After 22/12/2018 After

1. Download the BHS Events App Events BHS the Download 1.

downloaded the BHS Events App yet, you will need to download that App first. App that download to need will you yet, App Events BHS the downloaded 2019 MEETING ANNUAL GENERAL THE FOR REGISTRATION

The APP can be downloaded from the App Store and Google Play store. If you have not not have you If store. Play Google and Store App the from downloaded be can APP The

Download instructions Download www.BHS.be website via Registration

BHS EVENTS APP EVENTS BHS INFORMATION GENERAL BHS CORPORATE MEMBERS 2019 NOTES

PLATINUM

GOLD

SILVER

Bronze

BHS GAM EXHIBITORS 2019 Incyte Jazz Macopharma Mallinckrodt Merck Sharp & Dohme Sandoz Servier Shire SOBI

12 www.bhs.be www.bhs.be 13 NOTES

THE TOUGHEST WE CANCERS ARE MUST BE RESISTANT. PERSISTENT.

AT AMGEN ONCOLOGY, WE ARE FACING CANCER’S TOUGHEST CHALLENGES.

35 years of innovation by unlocking the world’s best science

10 oncology therapies providing targeted treatment and supportive care

1 mission to serve patients through our commitment to oncology

With a heritage in pioneering groundbreaking therapies, Amgen Oncology is working to solve the tough cancer mysteries so that you can be R.E. Amgen nv/sa Telecomlaan 5-7 1831 Diegem - BL-P-NPS-0617-051415(2) 14 www.bhs.be Creation date: 30th of October 2018 better armed against today’s fi ercest cancers. BHS Society Management Office

Congress Care P.O. Box 440 5201 AK ’s-Hertogenbosch The Netherlands [email protected] www.congresscare.com

www.bhs.be