In PubMed the search strategy will be:

((“Heart Defects, Congenital”[Mesh] OR “Congenital Heart Defect”[tw] OR “Congenital Heart

Defects”[tw] OR Heart Abnormalit*[tw] OR Aortic Coarctation*[tw] OR “Coarctation of the

Aorta”[tw] OR “Coarctation of Aorta”[tw] OR “ARVD-C”[tw] OR “Arrhythmogenic Right

Ventricular Cardiomyopathy”[tw] OR “Arrhythmogenic Right Ventricular

Dysplasia-Cardiomyopathy”[tw] OR “Barth Syndrome”[tw] OR “Cor Triatriatum”[tw] OR

“Subdivided Left Atrium”[tw] OR “Subdivided Left Atriums” OR Triatrial Heart*[tw] OR “Cor

Triatriatum Sinistrum”[tw] OR “Coronary Vessel Anomalies”[tw] OR “Coronary Vessel

Anomaly”[tw] OR Crisscross Heart*[tw] OR “Criss cross Heart”[tw] OR “Criss cross Hearts”[tw]

OR Dextrocardia*[tw] OR “Patent Ductus Arteriosus”[tw] OR “Patency of the Ductus

Arteriosus"[tw] OR Ebstein Anomal*[tw] OR Ebstein's Malformation*[tw] OR Ebstein

Malformation*[tw] OR Ebsteins Malformation*[tw] OR Ebstein's Anomal*[tw] OR Ebsteins

Anomal*[tw] OR “Ectopia Cordis”[tw] OR “Eisenmenger's Complex”[tw] OR “Eisenmenger

Complex”[tw] OR Eisenmenger's Syndrome*[tw] OR Eisenmengers Syndrome*[tw] OR

Eisenmenger Syndrome*[tw] OR “Heart Septal Defect”[tw] OR “Heart Septal Defects”[tw] OR

Atrial Isomerism*[tw] OR “Hypoplastic Left Heart Syndrome”[tw] OR “Isolated Noncompaction of the Ventricular Myocardium”[tw] OR LEOPARD Syndrome*[tw] OR “Cardio Cutaneous

Syndrome”[tw] OR Lentigines Syndrome*[tw] OR “Levocardia”[tw] OR Marfan Syndrome*[tw]

OR Marfan's Syndrome*[tw] OR Noonan Syndrome*[tw] OR “Tetralogy of Fallot”[tw] OR

“Fallot's Tetralogy”[tw] OR “Fallot Tetralogy”[tw] OR “Fallots Tetralogy”[tw] OR “Transposition of Great Vessels”[tw] OR “Great Vessels Transposition”[tw] OR “Transposition of Great

Arteries”[tw] OR “Great Arteries Transposition”[tw] OR “Dextro-Looped Transposition of the

Great Arteries”[tw] OR “Dextro Looped Transposition of the Great Arteries”[tw] OR

“Double-Outlet Right Ventricle”[tw] OR “Taussig-Bing Anomaly”[tw] OR Tricuspid Atresia*[tw]

OR “Tricuspid Valve Atresia”[tw] OR “Tricuspid Valve Atresias”[tw] OR “Absent Right

Atrioventricular Connection”[tw] OR “Trilogy of Fallot”[tw] OR “Fallot Trilogy”[tw] OR

“Fallot's Trilogy”[tw] OR Turner Syndrome*[tw] OR Turner's Syndrome*[tw] OR Turners

Syndrome*[tw] OR “Bonnevie Ullrich”[tw] OR “Congenital Heart Disease”[tw] OR “Congenital

Heart Diseases”[tw] OR “Congenital Cardiac Defect”[tw] OR “Congenital Cardiac Defects”[tw]

OR Naxos disease*[tw] OR “Holt Oram syndrome”[tw] OR “heart hand syndrome”[tw] OR “congenital heart block”[tw] ) AND ("Smoking"[Mesh] OR Smok*[tw] OR Tobacco*[tw] OR

Nicotiana*[tw] OR cigar*[tw] OR cannab*[tw]) AND (“Pregnancy”[Mesh] OR Pregnan*[tw] OR

Gestat*[tw] OR Gravidit*[tw] OR “child bearing”[tw] OR “childbearing”[tw]))

In EMBASE the strategy will be:

((“congenital heart disease”/exp OR “congenital heart disease” OR “congenital heart diseases” OR

“congenital cardiac disease” OR “congenital cardiac diseases” OR “congenital cardiac distress”

OR “congenital cardiac distresses” OR “congenital heart distress” OR “congenital heart distresses” OR “congenital heart failure” OR “congenital heart failures” OR “heart congenital disease” OR “heart congenital diseases” OR “neonatal cardiopathy” OR “persistent truncus arteriosus” OR “congenital heart block” OR “congenital cardiac block” OR “congenital cardial block” OR “congenital heart malformation” OR “congenital heart malformations” OR “congenital heart anomaly” OR “congenital heart anomalies” OR “congenital heart defect” OR “congenital heart defects” OR “heart right ventricle dysplasia” OR “arrhythmogenic heart right ventricle dysplasia” OR “arrhythmogenic right ventricular cardiomyopathy” OR “arrhythmogenic right ventricular dysplasia” OR “cardiomyopathy, arrhythmogenic right ventricular” OR “Naxos disease” OR “Naxos diseases” OR “right ventricular cardiomyopathy” OR “right ventricular dysplasia” OR “Holt Oram syndrome” OR “atriodigital syndrome” OR “heart hand syndrome”

OR “LEOPARD syndrome” OR “cardiocutaneous syndrome” OR “cardiomyopathic lentiginosis”

OR “lentiginosis profuse” OR “lentigines syndrome” OR “cardiomyopathic lentiginosis” OR

“McKusick Kaufman syndrome” OR “congenital heart block” OR “congenital cardiac block” OR

“congenital cardial block”) AND (“smoking”/exp OR smok* OR Tobacco* OR Nicotiana* OR cigar* OR cannab*) AND (“pregnancy”/exp OR pregnan* OR “child bearing” OR “childbearing”

OR gestat* OR gravidit*))

In WEB of SCIENCE the strategy will be:

((“Congenital Heart Defect” OR “Congenital Heart Defects” OR “Heart Abnormality” OR “Heart

Abnormalities” OR “Aortic Coarctation” OR “Aortic CoarctationS” OR “Coarctation of the

Aorta” OR “Coarctation of Aorta” OR “ARVD-C” OR “Arrhythmogenic Right Ventricular

Cardiomyopathy” OR “Arrhythmogenic Right Ventricular Dysplasia-Cardiomyopathy” OR “Barth Syndrome” OR “Cor Triatriatum” OR “Subdivided Left Atrium” OR “Subdivided Left Atriums”

OR “Triatrial Heart” OR “Triatrial Hearts” OR “Cor Triatriatum Sinistrum” OR “Coronary Vessel

Anomalies” OR “Coronary Vessel Anomaly” OR “Crisscross Heart” OR “Criss cross Heart” OR

“Criss cross Hearts” OR “Dextrocardia” OR “Patent Ductus Arteriosus” OR “Patency of the

Ductus Arteriosus" OR “Ebstein Anomaly” OR “Ebstein Anomalies” OR “Ebstein's

Malformation” OR “Ebstein's Malformations” OR “Ebsteins Malformation” OR “Ebsteins

Malformations” OR “Ebstein's Anomaly” OR “Ebstein's Anomalies” OR “Ebsteins Anomaly” OR

“Ebsteins Anomalies” OR “Ectopia Cordis” OR “Eisenmenger's Complex” OR “Eisenmenger

Complex” OR “Eisenmenger's Syndrome” OR “Eisenmengers Syndrome” OR “Eisenmenger

Syndrome” OR “Heart Septal Defect” OR “Heart Septal Defects” OR “Atrial Isomerism” OR

“Atrial Isomerism” OR “Hypoplastic Left Heart Syndrome” OR “Isolated Noncompaction of the

Ventricular Myocardium” OR “LEOPARD Syndrome” OR “Cardio Cutaneous Syndrome” OR

“Lentigines Syndrome” OR “Levocardia” OR “Marfan Syndrome” OR “Marfan's Syndrome” OR

“Noonan Syndrome” OR “Tetralogy of Fallot” OR “Fallot's Tetralogy” OR “Fallot Tetralogy” OR

“Fallots Tetralogy” OR “Transposition of Great Vessels” OR “Great Vessels Transposition” OR

“Transposition of Great Arteries” OR “Great Arteries Transposition” OR “Dextro-Looped

Transposition of the Great Arteries” OR “Dextro Looped Transposition of the Great Arteries” OR

“Double-Outlet Right Ventricle” OR “Taussig-Bing Anomaly” OR “Tricuspid Atresia” OR

“Tricuspid Valve Atresia” OR “Tricuspid Valve Atresias” OR “Absent Right Atrioventricular

Connection” OR “Trilogy of Fallot” OR “Fallot Trilogy” OR “Fallot's Trilogy” OR “Turner

Syndrome” OR “Turner's Syndrome” OR “Turners Syndrome” OR “Bonnevie Ullrich” OR

“Congenital Heart Disease” OR “Congenital Heart Diseases” OR “Congenital Cardiac Defect”

OR “Congenital Cardiac Defects” OR “Naxos disease” OR “Holt Oram syndrome” OR

“atriodigital syndrome” OR “heart hand syndrome” OR “congenital heart block” OR “congenital cardiac block” OR “congenital cardial block”) AND (Smok* OR Tobacco* OR Nicotiana* OR cigar* OR cannab*) AND (Pregnan* OR Gestat* OR Gravidit* OR “child bearing” OR

“childbearing”))