SWATI SINGH email: [email protected]

M.Phil., Ph.D. (Department of Zoology, University of )

ACADEMIC QUALIFICATION

Year Qualification Institute 2012 - 17 Ph.D. Zoology Department of Zoology, University of Delhi 2011 - 12 M.Phil. Zoology Department of Zoology, University of Delhi 2009 - 11 M.Sc. Zoology , University of Delhi 2006 - 09 B.Sc. Zoology (Hons.) Miranda House, University of Delhi

ACHIEVEMENTS AND AWARDS

1. ICMR-JRF/SRF, 2011 2. CSIR-UGC-NET, 2015 – Rank 37 3. International Travel award, Department of Biotechnology, 2016 4. International Travel award, Centre for International Co-operation in Science (CICS), 2016 5. Bill and Melinda Gates award, 2016

TEACHING EXPERIENCE

1. August 2018 till date – Assistant Professor, Zoology Department, Hansraj College, University of Delhi 2. 2017 – 2018 – Post doctoral fellow/Research Associate II, IIT Delhi 3. Jan’17 – Nov’17: Assistant Professor, Zoology Department, Miranda House, University of Delhi. 4. Feb’17 – Apr’17: Assistant Professor, Zoology Department, Hindu College, University of Delhi. 5. 2006 - 07: Teacher at Matri Karuna School, Sri Aurobindo Education Society for disadvantaged children.

POSITIONS OF RESPONSIBILITIES

1. Convener, Internal Auditing and Finance, Zoology Department, Hansraj College, University of Delhi 2. Member, Life Science Society, Life Science Department, Hansraj College, University of Delhi, 2019-2020 3. Resource Person and Script writing for class XI and XII Biology text book for video recording of lecture at CIET, NCERT 4. Member, Organizing Committee for National Symposium on "Recent Advances in Immunology", INSA, organized by Miranda House, University of Delhi, 2014. 5. Resource Person for workshop "Understanding proteins: Structure and Function", Miranda House, University of Delhi, 2013. 6. Resource person in Certificate Course in Medical Biotechnology conducted by Miranda House, University of Delhi, 2012-2013

RESEARCH EXPERIENCE

1. 2017-2018 – Research Associate II, Indian Institute of Technology Delhi, “Development of an Affordable, Automated and Field Deployable, Point of Care and Contained System for Rapid Diagnosis of TB Caused by Mycobacterium tuberculosis” 2. 2014 - 16: Senior Research Fellow, Miranda House, University of Delhi “Immunological Profile of Latency Associated Antigens Rv2626c and Rv2032 of Mycobacterium tuberculosis” 3. 2012 - 14: Junior Research Fellow, Miranda House, University of Delhi “Immunological Profile of Latency Associated Antigens Rv2626c and Rv2032 of Mycobacterium tuberculosis” 4. 2011 - 12: Research Fellow (M.Phil.), Department of Zoology, University of Delhi “Genetic Association of Cardiovascular Disease Susceptibility Genes in Granulosa Cells of Women with Polycystic Ovary Syndrome”

TECHNICAL SKILLS

1. Analytical techniques: Flow cytometry, Real Time PCR, Fluorescence microscopy 2. Cell culture: Handling mammalian cell lines (PBMC and THP1), Cloning and gene expression 3. Protein purification: Metal affinity chromatography, SDS–PAGE, Western blot, 4. Bioinformatics: Prediction of promiscuous T cell epitopes using Net MHC 3.4, BIMAS, IEDB and PROPRED, Peptide-HLA docking using CABSDOCK and Hex.

EXTRA CURRICULAR ACHIEVEMENTS

1. 1st Prize, Speed Dissection competition, Miranda House, University of Delhi, 2006 2. 2nd Prize, Inter College Debate competition, Miranda House, University of Delhi, 2006 3. Member of the Editorial Board of school magazine ‘Navchetna’, The Mother’s International School, 2006 4. Senior Diploma in Indian Classical Music, 2004.

LIST OF PUBLICATIONS

1. Swati Singh, Iti Saraav, Sadhna Sharma. Immunogenic potential of latency associated antigens against Mycobacterium tuberculosis. Vaccine (2014), 32: 712-716. ISSN: 0264-410X Impact Factor – 3.616

2. Iti Saraav, Swati Singh, Kirti Pandey, Monika Sharma, Sadhna Sharma. Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a Thl response. Tuberculosis (2017),106: 16-24.ISSN: 1472-9792. Impact Factor – 2.952

3. Swati Singh, Ila Pant. SPY-ing into protein stability. Indian Journal of Microbiology (2011),51(2): 242–243. ISSN: 0046-8991. Impact Factor – 1.143

4. Swati Singh, Kirti Pandey, Monika Sharma, Anil Chaudhry, Sadhna Sharma. Rv2626c and Rv2032 activate TH1 response and downregulate regulatory T cells in Peripheral Blood Mononuclear Cells of Tuberculosis Patients. Comparative Immunology, Microbiology and Infectious Diseases (2019), 62: 46-53. Impact factor – 1.92

5. Iti Saraav, Swati Singh, Sadhna Sharma. Outcome of Mycobacterium tuberculosis and Toll like receptor interaction: Immune Response or Immune Evasion? Immunology and Cell Biology (2014), 92: 741-746. ISSN: 0818-9641. Impact Factor – 4.147

6. Iti Saraav, Swati Singh, Kirti Pandey, Ekta Vishnoi, Monika Sharma, Sadhna Sharma. Cell wall- associated Mycobacterium tuberculosis rRv3083 protein stimulates macrophages through toll-like receptor-2 (TLR2). International Journal of Mycobacteriology (2014). 4: 176. ISSN: 2212-5531. SNIP - 0.105

7. Iti Saraav, Kirti Pandey, Richa Misra, Swati Singh, Monika Sharma, Sadhna Sharma. Characterisation of MymA protein as a Flavin containing monooxygenase and as a target of isoniazid. Chemical Biology and Drug Design (2017),2017 Jan;89(1):152-160. ISSN: 1747-0285. Impact Factor – 2.802

8. Iti Saraav, Kirti Pandey, Monika Sharma, Swati Singh, Prasun Dutta, Anshu Bhardwaj, Sadhna Sharma. Predicting promiscuous antigenic T cell epitopes of M.tuberculosisMymA operon proteins binding to MHC Class I and Class II alleles. Infection, Genetics and Evolution (2016), 44(5), 182-189. ISSN:15671348. Impact Factor – 2.591

9. Kirti Pandey, Monika Sharma, Iti Saraav, Swati Singh, Prasun Dutta, Anshu Bhardwaj, Sadhna Sharma. Analysis of the DosR regulon genes to select cytotoxic T lymphocyte epitope specific vaccine candidates using a reverse vaccinology approach. International Journal of Mycobacteriology (2015), Mar;5(1):34-43. ISSN: 2212-5531. SNIP: 0.105

10. Kirti Pandey, Swati Singh, Parul Bhatt, Medha, Monika Sharma, Anil Chaudhry, Sadhna Sharma DosR proteins of Mycobacterium tuberculosis upregulate effector T cells and down regulate T regulatory cells in TB patients and their healthy contacts. Microbial Pathogenesis (2019), 126: 399-406. Impact factor – 2.332

PAPERS PRESENTED IN INTERNATIONAL / NATIONAL CONFERENCES:

1. 5th Global Forum on TB Vaccine, , 20-23 February 2018.

2. Prediction of Antigenic Promiscuous MHC ClassII Binders of Mycobacterium tuberculosis Capable of Inducing Interferon Gamma. INSCR International conference, University of Delhi, 2017

3. Rv2626c and Rv2032 produce a TH1 response in Tuberculosis patients and their healthy contacts. Keystone symposia S1: Translational Vaccinology for Global Health. London, UK, 2016 (BILL AND MELINDA GATES AWARD WINNER).

4. Latency associated antigens Rv2032 and Rv2626c emerge as good vaccine candidates against Mycobacterium tuberculosis. 26th ECCMID (26th European Congress of Clinical Microbiology and Infectious Diseases), Amsterdam, Netherlands, 2016

5. Reverse immunology-an epitope driven vaccine design using DosR proteins. 10th Symposium on Frontiers in Biomedical Research, Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, 2015.

6. Characterization of MymA protein of Mycobacterium tuberculosis as flavin containing monooxygenase. 10th Symposium on Frontiers in Biomedical Research, Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, 2015.

7. Defining T cell epitopes from DosR regulon proteins of Mycobacterium tuberculosis as potential vaccine candidates, 18th Annual Conference on Vaccine Research, USA, 2015.

8. DosR regulon associated latency antigens as vaccine candidates against Mycobacterium tuberculosis. National Symposium on Recent Advances in Immunology, INSA, New Delhi, 2014. (BEST POSTER AWARD)

9. Latency antigens as vaccine candidates against Mycobacterium tuberculosis. Life Science Symposium Current Advances in Immunobiology and Cancer, BARC, Mumbai, 2013.

10. Mycobacterium tuberculosis Rv3083 (MymA) protein as a ligand for Toll like receptors (TLRs).Immunocon2013, 40th Annual Conference of Indian Immunology Society, UCMS, , 2013.

11. Polycystic Ovary Syndrome and Associated Insulin Resistance in North Indian Population. All Congress of Cytology & Genetics and Fogarty International Workshop, in Collaboration with Indian Institute of Chemical Biology, Kolkata and Fogarty Program at University of California, Berkeley, USA, held at Department of Botany, Magadh University, Bodhgaya, India, 2011.

12. Oil Eating Microbes – A Solution to Oil Spill Cleanup. Poster presented in Indo-Swiss Collaboration in Biotechnology (ISCB) International Conference, held at University of Delhi, Delhi, India, 2011.

13. Indo-Dutch Collaborative Program on Management and Cultural Contexts, University of Delhi and University of Applied Sciences, Utrecht, Netherlands, 2008