Supplementary Table 3: differentially expressed in HUH7 Cells after treatment with 10-3 M lidocaine. p <0.01; FC> 1.5 (FC: Fold-change; Lido: Lidocaine; Ctrl: Control)

UniqueID Name Accession UGCluster

Homo sapiens adenomatous polyposis coli (APC), transcript variant 3, mRNA A_23_P70213 [NM_000038] NM_000038 Hs.158932 Homo sapiens zinc finger 114 A_23_P368779 (ZNF114), mRNA [NM_153608] NM_153608 Hs.511883 Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-gamma, mRNA A_33_P3284345 [NM_004495] NM_004495 Hs.453951 Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-gamma, mRNA A_23_P315815 [NM_004495] NM_004495 Hs.453951 Homo sapiens aldo-keto reductase family 1, member B15 (AKR1B15), mRNA A_33_P3380992 [NM_001080538] NM_001080538 Hs.729418

Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) A_23_P93641 (AKR1B10), mRNA [NM_020299] NM_020299 Hs.116724 602418110F1 NIH_MGC_92 Homo sapiens cDNA clone IMAGE:4537298 5', A_21_P0011982 mRNA sequence [BG391804] BG391804 Hs.130011 Homo sapiens cDNA FLJ37411 fis, clone A_33_P3687198 BRAMY2028682. [AK094730] AK094730 Hs.26605 Homo sapiens ChaC, cation transport regulator homolog 1 (E. coli) (CHAC1), A_33_P3376965 transcript variant 1, mRNA [NM_024111] NM_024111 Hs.155569 Homo sapiens ankyrin repeat and SOCS box containing 2 (ASB2), transcript A_23_P205370 variant 2, mRNA [NM_016150] NM_016150 Hs.510327 A_33_P3279526 Homo sapiens solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 A_33_P3242623 (SLC7A11), mRNA [NM_014331] NM_014331 Hs.390594

Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) A_24_P129341 (AKR1B10), mRNA [NM_020299] NM_020299 Hs.116724 Homo sapiens fucosyltransferase 1 (galactoside 2-alpha-L- fucosyltransferase, H blood group) A_23_P107963 (FUT1), mRNA [NM_000148] NM_000148 Hs.69747 Homo sapiens cDNA FLJ30901 fis, clone A_33_P3480395 FEBRA2005778. [AK055463] AK055463 Homo sapiens organic solute transporter A_23_P436284 beta (OSTBETA), mRNA [NM_178859] NM_178859 Hs.534533 BROAD Institute lincRNA (XLOC_012981), lincRNA A_21_P0009686 [TCONS_00026908] PREDICTED: Homo sapiens hypothetical LOC284561 (LOC284561), miscRNA A_33_P3672756 [XR_112106] XR_112106 Hs.504540 Homo sapiens uncharacterized LOC442028 (LOC442028), non-coding A_21_P0011933 RNA [NR_037597] NR_037597 Q2VCE5_HUMAN (Q2VCE5) UCA1 A_21_P0009781 protein, partial (98%) [THC2492330] GU357550 BROAD Institute lincRNA (XLOC_004924), lincRNA A_21_P0004422 [TCONS_00010403] BROAD Institute lincRNA (XLOC_l2_013149), lincRNA A_21_P0013105 [TCONS_l2_00025502] BROAD Institute lincRNA (XLOC_l2_014504), lincRNA A_21_P0013514 [TCONS_l2_00028188] Homo sapiens hydroxysteroid (17-beta) dehydrogenase 14 (HSD17B14), mRNA A_23_P78762 [NM_016246] NM_016246 Hs.18788

PREDICTED: Homo sapiens hypothetical LOC100506860, transcript variant 1 A_19_P00316341 (LOC100506860), miscRNA [XR_108813] XR_108813 Homo sapiens harakiri, BCL2 interacting protein (contains only BH3 domain) A_23_P25194 (HRK), mRNA [NM_003806] NM_003806 Hs.87247 12 open reading frame 39 [Source:HGNC Symbol;Acc:28139] A_23_P2414 [ENST00000256969] AK311217 Hs.130692 Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding A_33_P3363188 RNA [NR_033856] NR_033856 Hs.632789 Homo sapiens transmembrane protein A_33_P3304372 144 (TMEM144), mRNA [NM_018342] NM_018342 Hs.176227 Homo sapiens urothelial associated 1 (non-protein coding) A_32_P200238 (UCA1), non-coding RNA [NR_015379] NR_015379 Hs.644234 Homo sapiens lactate dehydrogenase B (LDHB), transcript variant 1, mRNA A_23_P53476 [NM_002300] NM_002300 Hs.446149 Homo sapiens asparagine synthetase (glutamine-hydrolyzing) (ASNS), A_23_P145694 transcript variant 2, mRNA [NM_001673] NM_001673 Hs.489207 Homo sapiens annexin A3 (ANXA3), A_23_P121716 mRNA [NM_005139] NM_005139 Hs.480042

PREDICTED: Homo sapiens hypothetical LOC100506860, transcript variant 1 A_19_P00316340 (LOC100506860), miscRNA [XR_108813] XR_108813 Homo sapiens prosaposin-like 1 (/pseudogene) (PSAPL1), mRNA A_33_P3382999 [NM_001085382] NM_001085382 Hs.662523 Homo sapiens tripartite motif containing A_33_P3354451 31 (TRIM31), mRNA [NM_007028] NM_007028 Hs.493275

Homo sapiens serum amyloid A4, A_23_P87238 constitutive (SAA4), mRNA [NM_006512] NM_006512 Hs.1955 Homo sapiens chromosome 1 open reading frame 54 (C1orf54), mRNA A_23_P74778 [NM_024579] NM_024579 Hs.91283 Homo sapiens kelch domain containing A_23_P6535 7B (KLHDC7B), mRNA [NM_138433] NM_138433 Hs.137007 Homo sapiens argininosuccinate synthase 1 (ASS1), transcript variant 1, A_23_P31921 mRNA [NM_000050] NM_000050 Hs.160786 A_21_P0013618 BC090887 HUMTS11 ts11 control protein {Homo sapiens} (exp=-1; wgp=0; cg=0), A_21_P0013512 partial (34%) [THC2568453] BROAD Institute lincRNA (XLOC_l2_014191), lincRNA A_21_P0013475 [TCONS_l2_00027739] Homo sapiens lactate dehydrogenase B (LDHB), transcript variant 2, mRNA A_33_P3231432 [NM_001174097] NM_001174097 Hs.446149 Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 A_23_P67381 (SULT2A1), mRNA [NM_003167] NM_003167 Hs.515835 BROAD Institute lincRNA (XLOC_l2_005692), lincRNA A_21_P0011522 [TCONS_l2_00010603] A_24_P178444 BROAD Institute lincRNA (XLOC_l2_014505), lincRNA A_21_P0013513 [TCONS_l2_00028187] Homo sapiens cDNA clone A_33_P3777165 IMAGE:3831619. [BC022164] BC022164 Hs.596176 Homo sapiens CAP-GLY domain containing linker protein family, member 4 A_33_P3232458 (CLIP4), mRNA [NM_024692] NM_024692 Hs.122927 Homo sapiens UL16 binding protein 1 A_33_P3422802 (ULBP1), mRNA [NM_025218] NM_025218 Hs.653255 Homo sapiens family with sequence similarity 129, member A (FAM129A), A_24_P233786 transcript variant 2, mRNA [NM_052966] NM_052966 Hs.518662 Homo sapiens WD repeat domain 33 (WDR33), transcript variant 2, mRNA A_24_P102920 [NM_001006622] NM_001006622 Hs.554831 Homo sapiens solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 (SLC6A12), A_23_P76386 transcript variant 1, mRNA [NM_003044] NM_003044 Hs.437174 Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 1, A_23_P17065 mRNA [NM_004591] NM_004591 Hs.75498 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), A_23_P163402 mRNA [NM_000499] NM_000499 Hs.72912 Homo sapiens signal peptide, CUB domain, EGF-like 1 (SCUBE1), mRNA A_33_P3230990 [NM_173050] NM_173050 Hs.133995 Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2), transcript variant 2, mRNA A_23_P75811 [NM_001012662] NM_001012662 Hs.502769 Homo sapiens ChaC, cation transport regulator homolog 1 (E. coli) (CHAC1), A_33_P3376971 transcript variant 1, mRNA [NM_024111] NM_024111 Hs.155569 Homo sapiens family with sequence similarity 47, member E (FAM47E), transcript variant 2, mRNA A_32_P83811 [NM_001242936] NM_001242936 Hs.720509 Homo sapiens uncharacterized LOC100128822 (LOC100128822), non- A_32_P6172 coding RNA [NR_027387] NR_027387 Hs.647112 Homo sapiens nitric oxide synthase trafficker (NOSTRIN), transcript variant 1, A_23_P79360 mRNA [NM_052946] NM_052946 Hs.189780 Homo sapiens glucosaminyl (N-acetyl) transferase 3, mucin type (GCNT3), A_23_P420209 mRNA [NM_004751] NM_004751 Hs.194710 Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), transcript variant 5, A_23_P21134 mRNA [NM_004083] NM_004083 Hs.505777 Homo sapiens reticulocalbin 1, EF-hand calcium binding domain (RCN1), mRNA A_23_P203299 [NM_002901] NM_002901 Hs.97887 Homo sapiens syntaxin 3 (STX3), A_23_P139143 transcript variant 1, mRNA [NM_004177] NM_004177 Hs.180711 Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9), transcript variant 2, A_23_P11984 mRNA [NM_201649] NM_201649 Hs.442590 Homo sapiens Jun dimerization protein 2 (JDP2), transcript variant 1, mRNA A_23_P117582 [NM_130469] NM_130469 Hs.196482

PREDICTED: Homo sapiens hypothetical LOC100507660 (LOC100507660), A_21_P0014482 miscRNA [XR_110029] XR_110029 Hs.475364 Homo sapiens phosphoenolpyruvate carboxykinase 2 (mitochondrial) (PCK2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA A_33_P3268532 [NM_001018073] NM_001018073 Hs.75812 Homo sapiens argininosuccinate synthase 1 (ASS1), transcript variant 1, A_33_P3234580 mRNA [NM_000050] NM_000050 Hs.160786 Homo sapiens potassium voltage-gated channel, subfamily G, member 3 (KCNG3), transcript variant 1, mRNA A_32_P800799 [NM_133329] NM_133329 Hs.352633 Homo sapiens chromosome 6 open reading frame 1 (C6orf1), transcript A_23_P81993 variant 1, mRNA [NM_178508] NM_178508 Hs.381300 Homo sapiens RAS protein activator like A_23_P79069 3 (RASAL3), mRNA [NM_022904] NM_022904 Hs.136979 Homo sapiens sestrin 2 (SESN2), mRNA A_23_P35082 [NM_031459] NM_031459 Hs.469543 Homo sapiens lymphocyte cytosolic protein 1 (L-plastin) (LCP1), mRNA A_23_P204847 [NM_002298] NM_002298 Hs.381099 Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9), transcript variant 2, A_33_P3402615 mRNA [NM_201649] NM_201649 Hs.442590 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA A_23_P81399 [NM_003900] NM_003900 Hs.310781 Homo sapiens folliculin (FLCN), transcript A_23_P414308 variant 2, mRNA [NM_144606] NM_144606 Hs.31652 Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding A_21_P0010773 RNA [NR_033856] NR_033856 Hs.632789 Homo sapiens cDNA FLJ42199 fis, clone THYMU2034374, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 2, mRNA. A_33_P3393582 [AK124193] AK124193 Homo sapiens solute carrier organic anion transporter family, member 4C1 A_32_P154342 (SLCO4C1), mRNA [NM_180991] NM_180991 Hs.127648 Homo sapiens uncharacterized LOC401431 (LOC401431), non-coding A_32_P146659 RNA [NR_027040] NR_027040 Hs.556998 Homo sapiens SH2 domain containing 5 (SH2D5), transcript variant 1, mRNA A_24_P686965 [NM_001103161] NM_001103161 Hs.591522 Homo sapiens 6-phosphofructo-2- kinase/fructose-2,6-biphosphatase 2 (PFKFB2), transcript variant 2, mRNA A_24_P413669 [NM_001018053] NM_001018053 Hs.282702 Homo sapiens adaptor-related protein complex 1, mu 2 subunit (AP1M2), mRNA A_23_P78543 [NM_005498] NM_005498 Hs.18894 Homo sapiens sphingomyelin phosphodiesterase, acid-like 3B (SMPDL3B), transcript variant 2, mRNA A_23_P160881 [NM_001009568] NM_001009568 Hs.123659 Homo sapiens phosphoenolpyruvate carboxykinase 2 (mitochondrial) (PCK2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA A_23_P128817 [NM_004563] NM_004563 Hs.75812 Homo sapiens PR domain containing 8 (PRDM8), transcript variant 1, mRNA A_33_P3342126 [NM_020226] NM_020226 Hs.373642 Homo sapiens 6-phosphofructo-2- kinase/fructose-2,6-biphosphatase 2 (PFKFB2), transcript variant 1, mRNA A_33_P3300635 [NM_006212] NM_006212 Hs.282702 Homo sapiens solute carrier family 7 (amino acid transporter light chain, L system), member 5 (SLC7A5), mRNA A_24_P335620 [NM_003486] NM_003486 Hs.513797 Homo sapiens zinc finger protein 165 A_23_P93269 (ZNF165), mRNA [NM_003447] NM_003447 Hs.535177 Homo sapiens phosphoglycerate dehydrogenase (PHGDH), mRNA A_23_P85783 [NM_006623] NM_006623 Hs.487296 Homo sapiens protein kinase, cAMP- dependent, regulatory, type II, beta A_23_P42975 (PRKAR2B), mRNA [NM_002736] NM_002736 Hs.433068 Homo sapiens tribbles homolog 3 (Drosophila) (TRIB3), mRNA A_23_P210690 [NM_021158] NM_021158 Hs.516826 Homo sapiens adrenergic, beta-1-, A_33_P3310189 receptor (ADRB1), mRNA [NM_000684] NM_000684 Hs.99913 Homo sapiens fragile histidine triad gene (FHIT), transcript variant 1, mRNA A_33_P3216601 [NM_002012] NM_002012 Hs.655995 AF179597 connexin 59 {Homo sapiens} (exp=-1; wgp=0; cg=0), partial (10%) A_32_P214340 [THC2681034] Homo sapiens activating 3 (ATF3), transcript variant 4, A_24_P33895 mRNA [NM_001040619] NM_001040619 Hs.460 Homo sapiens inhibin, beta E (INHBE), A_24_P141707 mRNA [NM_031479] NM_031479 Hs.632713 BROAD Institute lincRNA (XLOC_006815), lincRNA A_21_P0005704 [TCONS_00014726] Homo sapiens seryl-tRNA synthetase (SARS), transcript variant 2, non-coding A_21_P0000629 RNA [NR_034072] NR_034072 Homo sapiens chromosome 6 open reading frame 115 (C6orf115), mRNA A_32_P160972 [NM_021243] NM_021243 Hs.600861 Homo sapiens lipase, endothelial (LIPG), A_24_P125469 mRNA [NM_006033] NM_006033 Hs.465102 Homo sapiens stanniocalcin 2 (STC2), A_23_P416395 mRNA [NM_003714] NM_003714 Hs.233160 Homo sapiens sulfiredoxin 1 (SRXN1), A_23_P320113 mRNA [NM_080725] NM_080725 Hs.516830 Homo sapiens sterol O-acyltransferase 2 A_23_P25475 (SOAT2), mRNA [NM_003578] NM_003578 Hs.656544 Homo sapiens prostaglandin reductase 1 (PTGR1), transcript variant 2, mRNA A_23_P157809 [NM_012212] NM_012212 Hs.584864 Homo sapiens bestrophin 1 (BEST1), A_23_P104996 transcript variant 1, mRNA [NM_004183] NM_004183 Hs.712676 full-length cDNA clone CS0DI053YO09 of Placenta Cot 25-normalized of Homo A_21_P0012185 sapiens (human) [CR614803] CR614803 Hs.561040 A_33_P3416414 Homo sapiens ceramide synthase 1 (CERS1), transcript variant 2, mRNA A_33_P3408320 [NM_198207] NM_198207 Hs.412355

prostaglandin reductase 1 [Source:HGNC A_33_P3396444 Symbol;Acc:18429] [ENST00000374313] AK309450 Hs.584864 centriolin [Source:HGNC A_33_P3257558 Symbol;Acc:1858] [ENST00000373844] A_24_P221485 Homo sapiens insulin receptor substrate A_24_P154037 2 (IRS2), mRNA [NM_003749] NM_003749 Hs.442344 Homo sapiens vesicle amine transport protein 1 homolog (T. californica) (VAT1), A_24_P152527 mRNA [NM_006373] NM_006373 Hs.514199 Homo sapiens interferon-related developmental regulator 1 (IFRD1), transcript variant 2, mRNA A_24_P137897 [NM_001007245] NM_001007245 Hs.7879 Homo sapiens kelch domain containing A_24_P117410 7B (KLHDC7B), mRNA [NM_138433] NM_138433 Hs.137007 Homo sapiens RAB3A interacting protein (rabin3)-like 1 (RAB3IL1), mRNA A_23_P75800 [NM_013401] NM_013401 Hs.13759 Homo sapiens tyrosyl-tRNA synthetase A_23_P379550 (YARS), mRNA [NM_003680] NM_003680 Hs.213264 Homo sapiens open reading frame 32 (C3orf32), mRNA A_23_P144005 [NM_015931] NM_015931 Hs.561182 Homo sapiens basic helix-loop-helix family, member e41 (BHLHE41), mRNA A_23_P139500 [NM_030762] NM_030762 Hs.177841 hh82d09.y1 NCI_CGAP_GU1 Homo sapiens cDNA clone IMAGE:2969297 5', A_21_P0004512 mRNA sequence [AW630386] AW630386 Hs.566332 Homo sapiens N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 2, A_33_P3316456 mRNA [NM_001200050] NM_001200050 Hs.496969 Homo sapiens NK3 homeobox 1 (NKX3- A_33_P3239347 1), mRNA [NM_006167] NM_006167 Hs.55999 Homo sapiens lipin 1 (LPIN1), mRNA A_32_P52609 [NM_145693] NM_145693 Hs.467740 Homo sapiens RAB32, member RAS family (RAB32), mRNA A_24_P303480 [NM_006834] NM_006834 Hs.287714

PREDICTED: Homo sapiens hypothetical LOC100507056 (LOC100507056), A_21_P0014214 miscRNA [XR_108886] XR_108886

Homo sapiens cartilage oligomeric matrix A_24_P264943 protein (COMP), mRNA [NM_000095] NM_000095 Hs.1584 Homo sapiens ADP-ribosylation factor- A_23_P138271 like 8A (ARL8A), mRNA [NM_138795] NM_138795 Hs.497399 Homo sapiens zinc finger protein 205 (ZNF205), transcript variant 1, mRNA A_24_P56689 [NM_003456] NM_003456 Hs.592088

Q58MP6_9CAUD (Q58MP6) A_19_P00322207 Dioxygenase, partial (8%) [THC2619587] AK093219 Hs.500498 Homo sapiens Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy- terminal domain, 2 (CITED2), transcript A_33_P3213374 variant 1, mRNA [NM_006079] NM_006079 Hs.82071 Homo sapiens uncharacterized serine/threonine-protein kinase SgK494 A_23_P415633 (SGK494), mRNA [NM_001174103] NM_001174103 Hs.729077 Homo sapiens uncharacterized LOC728730 (LOC728730), non-coding A_19_P00322118 RNA [NR_037875] NR_037875 Hs.655344 BROAD Institute lincRNA (XLOC_007506), lincRNA A_19_P00319099 [TCONS_00016118] A_33_P3333523 Homo sapiens MON1 homolog B (yeast) A_33_P3308626 (MON1B), mRNA [NM_014940] NM_014940 Hs.513743 Homo sapiens histone cluster 1, H1a A_23_P70448 (HIST1H1A), mRNA [NM_005325] NM_005325 Hs.150206 Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), mRNA A_23_P14986 [NM_000196] NM_000196 Hs.1376 Homo sapiens forkhead box B1 (FOXB1), A_23_P140527 mRNA [NM_012182] NM_012182 Hs.160375 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant A_33_P3383866 1, mRNA [NM_016381] NM_016381 Hs.707026 Homo sapiens chromosome 1 open reading frame 229 (C1orf229), mRNA A_24_P831309 [NM_207401] NM_207401 Hs.456511 Homo sapiens apolipoprotein A-IV A_23_P87036 (APOA4), mRNA [NM_000482] NM_000482 Hs.1247 PREDICTED: Homo sapiens ovostatin homolog 2-like (LOC728715), mRNA A_21_P0011089 [XM_003119524] XM_003119524 Homo sapiens small nucleolar RNA, H/ACA box 3 (SNORA3), small nucleolar A_21_P0000265 RNA [NR_002580] NR_002580 Hs.731297 Homo sapiens ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), transcript variant 1, mRNA A_33_P3278649 [NM_203468] NM_203468 Hs.123036 Homo sapiens dual specificity phosphatase 6 (DUSP6), transcript A_23_P139704 variant 1, mRNA [NM_001946] NM_001946 Hs.298654 PREDICTED: Homo sapiens ovostatin homolog 2-like (LOC728715), mRNA A_21_P0011087 [XM_003119524] XM_003119524 Homo sapiens docking protein 3 (DOK3), transcript variant 2, mRNA A_32_P121085 [NM_001144875] NM_001144875 Hs.720849 Homo sapiens NK1 homeobox 2 (NKX1- A_24_P256155 2), mRNA [NM_001146340] NM_001146340 Hs.712041 602018404F1 NCI_CGAP_Brn67 Homo sapiens cDNA clone IMAGE:4154136 5', A_33_P3635136 mRNA sequence [BF346224] BF346224 Hs.659987 (prosome, macropain) 26S subunit, non-ATPase, 5 [Source:HGNC A_33_P3305243 Symbol;Acc:9563] [ENST00000373903] AK001065 Homo sapiens dickkopf homolog 1 (Xenopus laevis) (DKK1), mRNA A_23_P24129 [NM_012242] NM_012242 Hs.40499 AGENCOURT_6611325 NIH_MGC_106 Homo sapiens cDNA clone IMAGE:5485440 5', mRNA sequence A_33_P3495962 [BM918074] BM918074 Hs.681779 Homo sapiens neuropeptide B (NPB), A_33_P3419970 mRNA [NM_148896] NM_148896 Hs.708916 Homo sapiens zinc finger protein 25 A_23_P381577 (ZNF25), mRNA [NM_145011] NM_145011 Hs.499429 Homo sapiens c- binding protein (MYCBP), transcript variant 1, mRNA A_23_P201655 [NM_012333] NM_012333 Hs.591506 Homo sapiens small Cajal body-specific RNA 8 (SCARNA8), guide RNA A_21_P0000354 [NR_003009] NR_003009 Hs.689635 Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), A_33_P3409062 transcript variant 1, mRNA [NM_003332] NM_003332 Hs.515369

sprouty homolog 1, antagonist of FGF signaling (Drosophila) [Source:HGNC A_33_P3268910 Symbol;Acc:11269] [ENST00000505319] Homo sapiens uncharacterized LOC100506124 (LOC100506124), non- A_21_P0014934 coding RNA [NR_045375] NR_045375 Homo sapiens phenylethanolamine N- methyltransferase (PNMT), mRNA A_23_P100642 [NM_002686] NM_002686 Hs.1892 PREDICTED: Homo sapiens ovostatin A_21_P0011085 (OVOS), mRNA [XM_001715897] XM_001715897 Hs.568152 A_23_P25069 XM_003119524 Hs.434604 Homo sapiens uncharacterized LOC145837 (LOC145837), non-coding A_32_P46594 RNA [NR_026979] NR_026979 Hs.410126

PREDICTED: Homo sapiens hypothetical LOC100506696, transcript variant 1 A_21_P0001711 (LOC100506696), miscRNA [XR_108329] XR_108329 Hs.23459 Homo sapiens tensin 1 (TNS1), mRNA A_33_P3209491 [NM_022648] NM_022648 Hs.471381 Homo sapiens tubulin, beta pseudogene 5 (TUBBP5), non-coding RNA A_33_P3241779 [NR_027156] NR_027156 Hs.513833

PREDICTED: Homo sapiens hypothetical LOC100506966 (LOC100506966), A_21_P0014213 miscRNA [XR_108881] XR_108881 Homo sapiens uncharacterized LOC388692 (LOC388692), non-coding A_21_P0010562 RNA [NR_027002] NR_027002 Homo sapiens solute carrier family 1 (glutamate transporter), member 7 A_23_P325562 (SLC1A7), mRNA [NM_006671] NM_006671 Hs.104637 Homo sapiens S100 calcium binding protein A4 (S100A4), transcript variant 1, A_23_P94800 mRNA [NM_002961] NM_002961 Hs.654444 Homo sapiens transmembrane protein A_24_P121956 86B (TMEM86B), mRNA [NM_173804] NM_173804 Hs.135215 Homo sapiens stimulated by retinoic acid gene 6 homolog (mouse) (STRA6), transcript variant 5, mRNA A_33_P3307500 [NM_001142620] NM_001142620 Hs.24553

Homo sapiens RNA, 5.8S ribosomal 1 A_33_P3399064 (RN5-8S1), ribosomal RNA [NR_003285] NR_003285 Hs.631413 Homo sapiens uncharacterized LOC389332 (LOC389332), non-coding A_33_P3368945 RNA [NR_024418] NR_024418 Hs.127680 Homo sapiens WD repeat domain 54 A_23_P68072 (WDR54), mRNA [NM_032118] NM_032118 Hs.643480 Homo sapiens tubulin, beta 8 class VIII (TUBB8), transcript variant 1, mRNA A_32_P16315 [NM_177987] NM_177987 Hs.532659 Homo sapiens organic solute transporter A_24_P385732 alpha (OSTalpha), mRNA [NM_152672] NM_152672 Hs.630585 Homo sapiens uncharacterized LOC284276 (LOC284276), non-coding A_33_P3387766 RNA [NR_015417] NR_015417 Hs.390287 PREDICTED: Homo sapiens similar to hCG1645807 (LOC100127987), mRNA A_33_P3374253 [XM_001717762] XM_001717762 Hs.336526 Homo sapiens complement component 8, alpha polypeptide (C8A), mRNA A_23_P46639 [NM_000562] NM_000562 Hs.93210 Homo sapiens stimulated by retinoic acid gene 6 homolog (mouse) (STRA6), transcript variant 8, mRNA A_33_P3307495 [NM_001199042] NM_001199042 Hs.24553 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA- DQB1), transcript variant 1, mRNA A_33_P3424222 [NM_002123] NM_002123 Hs.409934 Homo sapiens coiled-coil domain containing 64B (CCDC64B), mRNA A_33_P3335590 [NM_001103175] NM_001103175 Hs.513285 Homo sapiens KIAA1984 (KIAA1984), A_33_P3326730 mRNA [NM_001039374] NM_001039374 Hs.728796 Homo sapiens insulin-like growth factor binding protein 1 (IGFBP1), mRNA A_23_P42868 [NM_000596] NM_000596 Hs.642938 BROAD Institute lincRNA (XLOC_013949), lincRNA A_21_P0010313 [TCONS_00029224] Homo sapiens claudin 14 (CLDN14), A_23_P91512 transcript variant 1, mRNA [NM_144492] NM_144492 Hs.660278 Homo sapiens natriuretic peptide B A_23_P62752 (NPPB), mRNA [NM_002521] NM_002521 Hs.219140 Homo sapiens FXYD domain containing ion transport regulator 2 (FXYD2), A_23_P161769 transcript variant b, mRNA [NM_021603] NM_021603 Hs.413137 Homo sapiens natriuretic peptide B A_33_P3362008 (NPPB), mRNA [NM_002521] NM_002521 Hs.219140 Supplementary Table 3: Genes differentially expressed in HUH7 Cells after treatment with 10-3 M lidocaine. p <0.01; FC> 1.5 (FC: Fold-change; Lido: Lidocaine; Ctrl: Control)

Parametric p- Symbol FC Lido/Ctrl value

APC 3,95E-05 10,20

ZNF114 5,31E-05 3,33

NRG1 0,0015578 3,03

NRG1 0,0014302 2,86

AKR1B15 0,0023018 2,78

AKR1B10 0,0043253 2,78

XLOC_l2_008381 0,004752 2,63

LOC283454 0,0002596 2,56

CHAC1 0,0001191 2,56

ASB2 0,0009985 2,56 0,0011524 2,50

SLC7A11 1,37E-05 2,50

AKR1B10 0,0026272 2,44

FUT1 0,0003572 2,44

FLJ30901 0,0001318 2,33

OSTBETA 0,0013149 2,33

XLOC_012981 0,0093612 2,27

LOC284561 0,0004976 2,22

LOC442028 0,0005223 2,22

XLOC_012981 0,0036228 2,22

XLOC_004924 0,0059534 2,22 XLOC_l2_013149 2,20E-05 2,17

XLOC_l2_014504 0,0002196 2,13

HSD17B14 0,0006839 2,08

LOC100506860 0,0004978 2,08

HRK 0,0002003 2,04

C12orf39 0,0025176 2,04

FLJ43315 0,0001932 2,00

TMEM144 4,71E-05 2,00

UCA1 0,0082536 2,00

LDHB 0,0015323 2,00

ASNS 0,0003055 2,00

ANXA3 0,0043253 2,00

LOC100506860 0,0012345 2,00

PSAPL1 7,38E-05 1,96

TRIM31 0,0006696 1,96

SAA4 0,0014941 1,92

C1orf54 0,0021625 1,92

KLHDC7B 0,0001419 1,92

ASS1 0,0004986 1,92 FLJ35024 9,07E-05 1,92

XLOC_l2_014504 0,0004251 1,92

XLOC_l2_014191 0,0001581 1,92

LDHB 0,0029131 1,89 SULT2A1 0,0011277 1,89

XLOC_l2_005692 0,0018033 1,89 0,0004576 1,85

XLOC_l2_014505 0,0002741 1,85

FLJ31715 0,0004593 1,82

CLIP4 3,59E-05 1,82

ULBP1 0,0064033 1,79

FAM129A 4,08E-05 1,79

WDR33 0,0057484 1,79

SLC6A12 0,0036891 1,79

CCL20 5,64E-05 1,79

CYP1A1 0,0001601 1,79

SCUBE1 2,33E-05 1,75

SLC3A2 0,004307 1,75

CHAC1 0,0007024 1,72

FAM47E 0,0029301 1,72

LOC100128822 4,00E-05 1,72

NOSTRIN 0,0003161 1,72

GCNT3 0,0072662 1,72

DDIT3 0,0005194 1,72

RCN1 6,17E-05 1,72

STX3 0,0011097 1,72 SLC6A9 0,0071664 1,72

JDP2 0,0020155 1,72

LOC100507660 0,0039398 1,72

PCK2 0,0001502 1,69

ASS1 0,0007637 1,69

KCNG3 0,0003228 1,69

C6orf1 0,0001339 1,69

RASAL3 0,0041784 1,69

SESN2 0,0003196 1,69

LCP1 0,0083381 1,69

SLC6A9 0,0001034 1,67

SQSTM1 0,0009104 1,67

FLCN 0,0001144 1,67

FLJ43315 8,64E-05 1,67

CCNDBP1 0,0021686 1,64

SLCO4C1 0,0043492 1,64

LOC401431 0,0040702 1,64

SH2D5 0,0003161 1,64

PFKFB2 0,0001293 1,64

AP1M2 0,008582 1,64 SMPDL3B 0,0043176 1,64

PCK2 0,0001367 1,64

PRDM8 0,0068259 1,61

PFKFB2 0,0010184 1,61

SLC7A5 0,004005 1,61

ZNF165 0,0096105 1,61

PHGDH 0,0068671 1,61

PRKAR2B 0,0048075 1,61

TRIB3 0,0005198 1,61

ADRB1 0,000506 1,59

FHIT 0,0021493 1,59

0,0037186 1,59

ATF3 0,0024765 1,59

INHBE 0,0011664 1,59

XLOC_006815 0,0096694 1,59

SARS 0,0003757 1,59

C6orf115 0,0008872 1,56

LIPG 0,000269 1,56

STC2 0,0040631 1,56

SRXN1 0,0001985 1,56

SOAT2 0,0029526 1,56

PTGR1 0,001941 1,56

BEST1 0,0099014 1,56 XLOC_l2_009139 0,0058523 1,56 0,0013523 1,54

CERS1 0,0008516 1,54

PTGR1 0,0015697 1,54

CNTRL 0,0036612 1,54 0,0004041 1,54

IRS2 0,0006368 1,54

VAT1 0,0032074 1,54

IFRD1 0,0019251 1,54

KLHDC7B 0,0050273 1,54

RAB3IL1 0,0008282 1,54

YARS 0,0009951 1,54

C3orf32 0,0012868 1,54

BHLHE41 0,0002134 1,54

XLOC_004430 0,0013589 1,54

NPL 0,000349 1,52

NKX3-1 0,001908 1,52

LPIN1 0,0004476 1,52

RAB32 0,000398 1,52

LOC100507056 0,00943 1,52

COMP 0,0023043 1,49

ARL8A 0,0008954 1,49

ZNF205 0,0094506 0,67

Q58MP6 0,0088165 0,67 CITED2 0,0031812 0,66

SGK494 0,0068137 0,66

LOC728730 0,0088979 0,66

XLOC_007506 0,0037176 0,66 0,0007345 0,66

MON1B 0,003111 0,66

HIST1H1A 0,0076272 0,66

HSD11B2 0,0002408 0,66

FOXB1 0,0058018 0,66

TREX1 0,0014251 0,65

C1orf229 0,0077046 0,65

APOA4 0,0014015 0,65

XLOC_l2_003293 0,0062412 0,65

SNORA3 0,0015181 0,65

ENTPD2 0,006361 0,65

DUSP6 0,0001413 0,65

LOC728715 0,0031391 0,65

DOK3 0,003084 0,64

NKX1-2 0,0018633 0,64

0,0003137 0,63

PSMD5 0,0020211 0,63

DKK1 0,0098536 0,63

SNORA71A 0,0065683 0,63 NPB 0,0033692 0,62

ZNF25 0,0039266 0,62

MYCBP 0,0099764 0,62

SCARNA8 0,0072226 0,62

TYROBP 0,0003732 0,62

SPRY1 0,0080391 0,62

LOC100506124 0,006424 0,62

PNMT 0,0007093 0,61

XLOC_l2_003293 0,0062614 0,61 0,0018646 0,61

LOC145837 0,0051128 0,61

XLOC_000527 0,0034013 0,59

TNS1 0,0033914 0,59

TUBBP5 0,0023481 0,58

LOC100506966 0,0004884 0,58

LOC388692 0,0039489 0,58

SLC1A7 0,0064578 0,57

S100A4 0,0038536 0,56

TMEM86B 0,0001402 0,55

STRA6 0,0016025 0,55

RN5-8S1 0,003712 0,54

LOC389332 6,00E-05 0,54

WDR54 0,0047812 0,53 TUBB8 0,0002478 0,52

OSTalpha 0,0086079 0,52

LOC284276 0,009533 0,50

0,0063609 0,48

C8A 0,0002928 0,47

STRA6 0,0022769 0,46

HLA-DQB1 0,0004535 0,46

CCDC64B 0,0028626 0,44

KIAA1984 0,0081098 0,43

IGFBP1 0,0049247 0,39

XLOC_013949 0,000155 0,36

CLDN14 0,000838 0,34

NPPB 0,0009664 0,34

FXYD2 0,0002262 0,34

NPPB 0,0009594 0,33