Perspective Australia is responding to the complex challenge of overdiagnosis
An Australian alliance of clinical, consumer, research and public organisations is emerging to tackle overdiagnosis
verdiagnosis is now a health challenge the topic from the National Health and Medical Research recognised across many nations.1 Debates about Council (NHMRC). A Centre for Research Excellence and O its definition continue, but in short, a Program Grant funded by the NHMRC have joined to overdiagnosis happens when health systems routinely form the Wiser Healthcare research collaboration on diagnose people in ways that do not benefit them or that overdiagnosis to produce and translate evidence (www. even do more harm than good.2 Overdiagnosis is wiserhealthcare.org.au). Catalysed by this research and unwarranted diagnosis, leading to harms from the work of others nationally and globally, there is unnecessary labels and treatments and to the waste of increasing recognition of the need for some form of health care resources that could be better spent dealing coordinated national response to develop evidence- with genuine needs. To manage overdiagnosis and the informed strategies that can fairly and safely deal with the sustainability of the health system more broadly, problem of overdiagnosis. As a result, new relationships Ray Moynihan1 reversing the harm of too much medicine is becoming a are being built between clinicians, researchers, Alexandra L health care priority, demanding effective responses in stakeholders and decision makers around this counter- Barratt2 policy and practice. In Australia, a new alliance is intuitive health challenge, and a national response is developing a national plan to deal with this problem. emerging. Rachelle 3,4 Buchbinder While research on the size of the problem continues, a In preparation for a national plan of response, a map of Stacy M Carter5 group convened by the National Cancer Institute in the the possible drivers of overdiagnosis and its potential United States has concluded that “overdiagnosis is solutions was developed from the medical literature Thomas Dakin2 common”,3 and it has been described as a “modern across five interrelated domains.12 As the map shows 6 Jan Donovan epidemic”.4 In 2016, for example, researchers estimated (Box 1), the key drivers include, but are in no way Adam G Elshaug7 that over 500 000 people may have been overdiagnosed limited to: with thyroid cancer across 12 nations over two decades.5 Paul P Glasziou1 An ongoing series of articles6 has raised concerns about cultural beliefs that more tests and treatments are Christopher G overdiagnosis across a wide range of conditions, better; 8 Maher including pulmonary embolism, attention deficit/ financial incentives at the health system level; Kirsten J hyperactivity disorder and pre-diabetes. While technological change enabling identification of 2 McCaffery overdiagnosis is but one driver of the wider problem of smaller and more minor abnormalities; 7 9,10 too much unsafe, ineffective and inappropriate care, Ian A Scott professional fear of missing disease and cognitive early evidence from Australian research suggests that too 13 biases in decision making; and 1 Centre for Research in many people are also receiving diagnoses unlikely to Evidence-Based 8 public expectations that clinicians will “do Practice, Bond benefit them. University, something”. Gold Coast, QLD. Internationally, there are growing numbers of initiatives The recent analysis of the overdiagnosis literature also 2 University of Sydney, to respond to overdiagnosis. The Overdiagnosis Working Sydney, NSW. identified many potential solutions (Box 1), including: 3 Cabrini Institute, Group from the Guidelines International Network is now Melbourne, VIC. tackling the problem of inappropriately widened disease evidence-based public awareness campaigns; 4 Monash University, definitions — regarded as a key driver of the problem Melbourne, VIC. reformed system incentives to reward quality rather (www.g-i-n.net). In August 2018, Danish general 5 University of than quantity; Wollongong, practitioners held the 6th International Scientific Wollongong, NSW. Conference on Preventing Overdiagnosis (www. better management of the problem of expanding 6 Consumers Health fi Forum of Australia, preventingoverdiagnosis.net), while in the United disease de nitions; Canberra, ACT. Kingdom, a standing group from the Royal College better evaluation of the accuracy and utility of 7 Menzies Centre for Health Policy, University of General Practitioners is already addressing diagnostic tests; 9 of Sydney, overdiagnosis. In Québec, Canada, a province-wide plan more professional education about overdiagnosis; Sydney, NSW. to raise awareness about and reduce overdiagnosis is 8 George Institute for 10 and Global Health, being driven by the Québec Medical Association. 15 October 2018 greater promotion of shared decision making. j University of Sydney, Related but separate initiatives include Choosing Wisely, Sydney, NSW. 9 Princess Alexandra which lists overused interventions in over 20 nations Identifying enablers of, and barriers to, these potential Hospital, Brisbane, QLD. (www.choosingwisely.org), and the Right Care Alliance solutions will help meet the inevitable challenges of 10 University of in the United States (https://rightcarealliance.org), which Queensland, implementation, as will analysing strategies rolled
MJA 209 (8) Brisbane, QLD. is working to reduce overuse and is responsible for a out elsewhere. For example, in response to evidence of too 11 RayMoynihan@ landmark series in early 2017. many diagnoses of small lung nodules with a bond.edu.au In Australia, the evidence base regarding the extent, low probability of being cancer, radiologist guidelines in 332 causes and interventions to deal with overdiagnosis is the US recently raised the minimum threshold size for 14 doi: 10.5694/mja17.01138 growing, not least because of recent research funding on routine follow-up of incidentally detected nodules. Perspective
1 Possible drivers and potential solutions to overdiagnosis and related overuse
COIs ¼ conflicts of interest. OD ¼ overdiagnosis. OU ¼ overuse. Source: Figure reproduced, with permission, from Pathirana et al.12 u
A series of preliminary meetings in Australia culminated working with colleges and consumer organisations, with a National Summit on Overdiagnosis held at the while the Royal Australasian College of Physicians is University of Sydney in July 2017. Sixty invited running its EVOLVE initiative (https://evolve.edu.au)to participants came from leading clinical, consumer, identify and reduce clinical interventions that “add research and public organisations with an interest in little or no value to patient care”.15 Atthesametime,the overdiagnosis, with widespread agreement that action Atlas of Healthcare Variation of the Australian was needed. A month after the summit, the Wiser Commission on Safety and Quality in Health Care is Healthcare research collaboration published a short identifying many areas of potential overuse (and Initial Statement to underpin the development of a underuse), and it is developing clinical care standards to National Action Plan to Prevent Overdiagnosis and help manage these issues (www.safetyandquality.gov. Overtreatment in Australia (Box 2), which was publicly au). It is clear that translating these initiatives into endorsed by some of Australia’s most influential health changes in clinical practice and improvements in care organisations. Asserting that overdiagnosis is health outcomes is a complex challenge that requires causing harm and diverting resources from tackling multilevel strategies. underdiagnosis and undertreatment, the Initial Statement reads: “There is need in Australia to identify After the 2017 National Summit and the subsequent the causes of too much medicine, the extent of the release of the statement on overdiagnosis, and problem, and to develop responses to address it”. The considering the broad range of drivers and potential fi statement calls for robust evaluation of strategies to deal solutions identi ed in the mapping process (Box 1), a with this challenge, and affirms a commitment “to range of activities are now underway. In the wider optimise the Australian health system’s safety, efficiency cultural domain, responding to the clear need for more (8) 209 MJA and equity of access”. Endorsement is open to any information and awareness and in consultation with organisation via the NHMRC-funded Wiser Healthcare health consumer groups, a series of accessible information research collaboration on overdiagnosis, which is sheets about overdiagnosis, in different formats across — facilitating this work as part of its commitment to several conditions, are being prepared including, for j research translation. example, thyroid cancer overdiagnosis. The aim is to help 2018 October 15 inform a wider national conversation. At the level of the As is the case internationally, individual organisations in health system, there is bipartisan recognition of the need Australia are already addressing different aspects of the for a comprehensive initiative to ensure that clinical wider problem of too much medicine. Health technology practice aligns with evidence and delivers health assessment agencies, such as the Health Policy Advisory outcomes. The federal government’s Medicare Benefits Committee on Technology (www.inahta.org/members/ Schedule Review Taskforce has identified overdiagnosis healthpact), have been engaged with disinvestment as both a driver of overuse and a downstream strategies, including modifying reimbursement consequence of overtesting, and it is developing a series of 333 processes. More recently, Choosing Wisely has been responses. In the professional domain, accessible Perspective
In the research arena in Australia, many projects are now 2 Initial statement to underpin the development of a National Action Plan to Prevent Overdiagnosis and underway to understand overdiagnosis and investigate Overtreatment in Australia* responses, including: