bioRxiv preprint doi: https://doi.org/10.1101/567800; this version posted March 5, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Title: Translational products encoded by novel ORFs may form protein-like structures and have biological functions 1† 2† 3† 3† Authors: Chaitanya Erady , David Chong , Narendra Meena , Shraddha Puntambekar , Ruchi 1† 4 5 5 6 Chauhan , Yagnesh Umrania , Adam Andreani , Jean Nel , Matthew T. Wayland , Cristina 7 4 1,2,3 Pina , Kathryn S. Lilley , & Sudhakaran Prabakaran * Affiliations: 1 Department of Genetics, University of Cambridge, Downing Site, CB2 3EH, UK. 2 St Edmund’s College, University of Cambridge, CB3 0BN, UK 3 Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India 4 Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom 5 Downing College, University of Cambridge, CB2 1DQ, UK 6 Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK 7 Department of Haematology, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK *Corresponding author, email:
[email protected]. †These authors contributed equally to the work. 1 bioRxiv preprint doi: https://doi.org/10.1101/567800; this version posted March 5, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract: Translation products encoded by non canonical or novel open reading frame (ORF) genomic regions are generally considered too small to play any significant biological role, and dismissed as inconsequential.