Generated by SRI International Pathway Tools Version 25.0, Authors S

Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000328925Cyc: Nitrosopumilus sp. AR Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari phosphate phosphate phosphate

ammonium

RS0102600 PhnD RS0114585 RS0106145

phosphate phosphate ammonium phosphate

Carboxylate NADPH repair (eukaryotes) Degradation an N 6 -L- 7,8-didemethyl- 3-(D-glyceryl) 7,8-didemethyl- enolpyruvoyl- all-trans- a [bis(guanylyl 2,5-diamino-6- an [amino-group an N-terminal- a sulfurated an [amino-group N-acetyl-L- propanoyl CoA threonylcarbamoyladenine 37 8-hydroxy-5- -diphospho- 8-hydroxy-5- 2-diphospho- heptaprenyl sn-glycerol an alkylated DNA 5'-deoxyadenosine L-methionyl-L- F6P 5-MTR-1-P Carbohydrate Biosynthesis molybdopterin) cys GTP carrier protein]- (5-phospho-D- carrier protein]- ATP NADPH degradation I [sulfur carrier] 1-phosphate γ ornithine in tRNA deazariboflavin 5'-guanosine deazariboflavin 5'-guanosine diphosphate cofactor C-terminal-γ- ribosylamino) C-terminal- - alanyl-[protein] biotin acetylornithine/ glutamine-- S-methyl-5- L-asparagine biosynthesis gln Aminoacyl-tRNA Charging glutaminyl-tRNA chaperone]- (L-glutamate 5- pyrimidin- (L-ornithyl)acetylornithine/ succinylornithine fructose-6- thioribose-1- III (tRNA-dependent) gluconeogenesis I propanoyl-CoA DNA-3- N-acetyl-gamma- S-methyl-5'- 2,5-diamino-6- biosynthesis via transamidation dTDP-β-L-rhamnose tRNA (N(6)-L- 2-phospho-L- 2-phospho-L- geranylgeranylglyceryl/ L-cysteine semialdehyde-2- 4(3H)-one -L-glutamatesuccinylornithine type II methionyl family phosphate phosphate acyl-CoA methyladenine glutamyl-phosphate thioadenosine (ribosylamino)- biotin--[acetyl-CoA- biosynthesis threonylcarbamoyladenosine(37) lactate transferase: lactate transferase: heptaprenylglyceryl GTP yl)-L-glutamate family aminopeptidase: transaminase: transaminase isomerase: asp (S)-malate carboxylase glycosylase: reductase: phosphorylase: 4(3H)-pyrimidinone carboxylase] ligase: glu -C(2))- methylthiotransferase: NAR_RS0115490 NAR_RS0115490 phosphate synthase: cyclohydrolase transaminase: NAR_RS0115410 NAR_RS0111360 (isomerizing) mtnA α-D-glucopyranose subunit beta: cysteine NAR_RS0110425 NAR_RS0118950 NAR_RS0118465 5'-phosphate NAR_RS0120550 (R)-NADPHX NAD(P)H-hydrate NAR_RS0119030 NAR_RS0103145 I FolE: folE NAR_RS0111360 : glmS aspartate-- 1-phosphate NAR_RS0104745 2-phospho-L- 2-phospho-L- desulfurase: DNA-3- S-methyl-5'- reductase: type II methionyl acetylornithine/ S-methyl-5- epimerase: GTP N-acetyl-gamma- biotin--[acetyl-CoA- glutamine-- tRNA(Asn) malate tRNA (N(6)-L- lactate transferase: lactate transferase: geranylgeranylglyceryl/ NAR_RS0113715 methyladenine thioadenosine NAR_RS0112400 acetylornithine/ aminopeptidase: succinylornithine thioribose-1- NAR_RS0113615 acyl-CoA cyclohydrolase glutamyl-phosphate carboxylase] ligase: fructose-6- ligase: aspS dehydrogenase: α threonylcarbamoyladenosine(37) NAR_RS0106930 NAR_RS0106930 heptaprenylglyceryl [+ 3 isozymes] glycosylase: an [amino-group phosphorylase: 2,5-diamino-6- succinylornithine NAR_RS0106855 family phosphate dTDP- -D-glucose carboxylase I FolE: folE reductase: NAR_RS0109550 phosphate NAR_RS0105100 NAD(P)H-hydrate -C(2))- methylthiotransferase: phosphate synthase: NAR_RS0119975 carrier protein]- NAR_RS0101225 (ribosylamino)- family transaminase: isomerase: [+ 3 isozymes] gln an L-glutamyl- dTDP-glucose 4,6- subunit beta: NAR_RS0111350 transaminase malate epimerase: NAR_RS0111275 oxidized 3PG- dehydro NAR_RS0116220 a [bis(guanylyl C-terminal-γ- 4(3H)-pyrimidinone transaminase: an N-terminal L- N-acetyl-L-NAR_RS0118940 S-methyl-5-mtnA an L-aspartyl- [tRNA Gln ] dehydratase: rfbB NAR_RS0113290 7,8- an [amino-group (isomerizing) dehydrogenase: NAR_RS0105015 (S)-methylmalonyl- factor 420-0 factor 420-0 ala molybdopterin) (5-phospho- 5'-phosphate NAR_RS0118940 met alanyl-[protein] biotinyl-5'- glutamate 5- thio-D-ribulose [tRNA Asn ] imidazole GMP GMP a DNA containing formate 5-deoxy-α- carrier protein]- Asp-tRNA(Asn) NAR_RS0113700 dTDP-4-dehydro-6- (S)-NADPHX CoA a 2-methylsulfanyl-N 6 -L- 3-heptaprenyl- cofactor an alkylated dihydroneopterin adenylate : glmS glycerol an apurinic/ L-glutamyl)- D-ribose 1- 2,5-diamino-6-reductase: C-terminal-γ- semialdehyde D-glucosamine 1-phosphate Asp-tRNA(Asn) /Glu-tRNA(Gln) deoxy-α-D-glucopyranose methylmalonyl- threonylcarbamoyladenine 37 5'-deoxyadenosine an unsulfurated sn-glycero- chaperone]-S- nucleobase 3'-triphosphate adenine gln phosphate NAD(P)H-hydrate met apyrimidinic site L-glutamate phosphate (5-phospho-NAR_RS0102335 (L-glutamate 5- 6-phosphate /Glu-tRNA(Gln) amidotransferase: dTDP-4- CoA epimerase: in tRNA [sulfur carrier] 1-phosphate sulfanyl-L-cysteine synthase: oxaloacetate dehydratase: D-ribitylamino) semialdehyde-2- amidotransferase: gatB gatA dehydrorhamnose NAR_RS0121680 imidazole hisF hisH NAR_RS0100170 pyrimidin- yl)-L-glutamate sulfite RS0120035 sulfite gatA gatB [+ 3 isozymes] 3,5-epimerase: rfbC [+ 3 isozymes] glycerol [+ 14 isozymes] ATP biosynthesis NAD(P)H-hydrate 4(3H)-one Asp-tRNA(Asn) a 5-phosphooxy- phosphoenolpyruvate [+ 2 isozymes] (R)-methylmalonyl- phosphate pyruvate dehydratase: /Glu-tRNA(Gln) ammonium L-glutamyl- tRNA charging carboxykinase dTDP-4-dehydro- CoA synthase: Gln NAR_RS0107330 α H+transporting [tRNA ] (ATP): pckA β-L-rhamnose a [DNA]-3'- a 5'-phospho- (1S,2R)-1- a peptide with an N-terminal- an N-terminal- a [DNA]-3'- a 5'-phospho- an N-terminal- an N-terminal- 5-deoxy- - + + amidotransferase: methylmalonyl- + + an L-asparaginyl- CAIR H H hisF hisH ADP a 2-oxo carboxylate NAD DL-allothreonine ser C-(indol-3- menadione NADH H an N-terminal L-methionyl-L- L-methionyl-L- 3',5'-ADP sulfite L-methionyl-L- L-methionyl-L- D-ribose 1- two-sector ATPase gatB gatA phosphoenolpyruvate phosphoenolpyruvate dTDP-4- NADPH CoA mutase: hydroxyl [DNA] hydroxyl [DNA] [tRNA Asn ] AMP [+ 14 isozymes] Asp-tRNA(Asn) phe Phe arg Arg yl)glycerol Xaa-L-proline cysteinyl-[protein] threonyl-[protein] seryl-[protein] valyl-[protein] sulfite 5-(carboxyamino) phosphate a 4-phosphooxy- a tRNA a tRNA carboxykinase synthetase: dehydrorhamnose H+transporting two- NAR_RS0120800 S-methyl-5- /Glu-tRNA(Gln) sector ATPase: 3-phosphate imidazole ammonium L-aspartyl- (ATP): pckA NAR_RS0109355 reductase: rfbD 2-oxoacid ferredoxin ATP-dependent NADH-quinone ATP-dependent thioribose-1- His Leu Ala Lys Pro Tyr Gly Trp Ile Cys elongator Met Thr methylmalonyl- phosphoadenylyl- ribonucleotide H+transporting [tRNA Asn ] amidotransferase: his a tRNA leu a tRNA a tRNA ala lys a tRNA pro a tRNA tyr a tRNA gly a tRNA trp a tRNA ile a tRNA cys a tRNA met initiator tRNA met thr a tRNA NAR_RS0102555 serine leucyl type II methionyl type II methionyl peptidyl-tRNA type II methionyl type II methionyl phosphate + + tRNA Met dTDP-β-L-rhamnose CoA mutase: oxidoreductase DNA ligase: tryptophan oxidoreductase: DNA ligase: H H gatB gatA phenylalanine- arginine- NAR_RS0102565 hydroxymethyltransferase: aminopeptidase: aminopeptidase: aminopeptidase: sulfate reductase: hydrolase: aminopeptidase: aminopeptidase: phosphoadenylyl- mutase: purE two-sector ATPase NAR_RS0109370 subunit beta: NAR_RS0109775 synthase: trpB NAR_RS0113325 NAR_RS0120070 isomerase: -tRNA ligase: -tRNA asp Val phosphoenolpyruvate NAR_RS0116490 sulfate reductase: Asp-tRNA(Asn) [+ 3 isozymes] tRNA asp ser a tRNA ser val a tRNA NAR_RS0102570 NAR_RS0103135 NAR_RS0113490 NAR_RS0115410 NAR_RS0115410 NAR_RS0119270 NAR_RS0115410 NAR_RS0115410 5-(carboxyamino) mtnA NAR_RS0117780 ligase: NAR_RS0105685 ATP-dependent NAR_RS0109100 nuoH nuoK ATP-dependent NAR_RS0103440 /Glu-tRNA(Gln) histidine- glu glu leucine- alanine-- lysine- proline-- tyrosine-- glycine- tryptophan-- isoleucine-- cysteine-- methionine- methionine- threonine-- NAR_RS0102575 succinyl-CoA serine leucyl type II methionyl type II methionyl phosphoadenylyl- peptidyl-tRNA type II methionyl type II methionyl imidazole a tRNA enolase: DNA ligase: DNA ligase: S-methyl-5- + + amidotransferase: NAR_RS0117785 argS -tRNA -tRNA tRNA ligase: -tRNA tRNA ligase: tRNA ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: NAR_RS0102580 2-oxoacid ferredoxin tryptophan NADH-quinone sulfate reductase: phosphoadenylyl- ribonucleotide H RS0110515 H an L-glutaminyl- NAR_RS0104995 NAR_RS0120070 hydroxymethyltransferase: aminopeptidase: aminopeptidase: aminopeptidase: NAR_RS0109775 hydrolase: aminopeptidase: aminopeptidase: thioribose-1- gatA gatB Gln aspartate-- ligase: hisS ligase: leuS NAR_RS0113895 ligase: lysS NAR_RS0115650 NAR_RS0115920 ligase: glyS NAR_RS0117775 valine--tRNA ligase: NAR_RS0119660 NAR_RS0120670 ligase: metG ligase: metG NAR_RS0121125 asn tRNA Asn gln a tRNA Gln oxidoreductase synthase: oxidoreductase: NAR_RS0103440 sulfate reductase: mutase: purE [tRNA ] phenylalanine- arginine- serine- enolase: [+ 2 isozymes] NAR_RS0116210 NAR_RS0104880 NAR_RS0106855 NAR_RS0106855 NAR_RS0110920 NAR_RS0106855 NAR_RS0106855 phosphate tRNA(Asn) NAR_RS0117970 ATP subunit beta: NAR_RS0121170 NAR_RS0104780 NAR_RS0116490 Asp-tRNA(Asn) -tRNA ligase: -tRNA histidine- glutamate- leucine- alanine-- lysine- proline-- tyrosine-- glycine- -tRNA tryptophan-- isoleucine-- cysteine-- methionine- methionine- threonine-- NAR_RS0113595 AIR isomerase: NAR_RS0101610 ligase: ligase: aspS -tRNA -tRNA -tRNA tRNA ligase: -tRNA tRNA ligase: tRNA ligase: -tRNA ligase: tRNA ligase: valine--tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: NAR_RS0114300 trpB nuoH nuoK a reduced /Glu-tRNA(Gln) 2-oxobutanoate [DNA] NMN a peptide with an N-terminal L- an N-terminal L- [DNA] an N-terminal an N-terminal 5-deoxy-D-mtnA NAR_RS0101615 argS [+ 3 isozymes] ligase: hisS ligase: gltX ligase: leuS NAR_RS0105315 ligase: lysS NAR_RS0107155 NAR_RS0102900 ligase: glyS serS NAR_RS0101620 NAR_RS0101495 NAR_RS0110710 NAR_RS0109450 ligase: metG ligase: metG NAR_RS0109165 2-phospho-D-glycerate AMP acetaldehyde a proteinogenic PAPS Asn H O c-type amidotransferase: gly D-glyceraldehyde an N-terminal met met asn tRNA met met ribulose 1- 2 degradation II amino acid cysteinyl-[protein] threonyl-[protein] L-seryl-[protein] L-valyl-[protein] APS RS0117065 cytochrome gatB gatA an acyl-CoA CO H + a reduced ferredoxin 3-phosphate trp NAD + menadiol L-proline phosphate an oxidized an L-methionyl- 2,3-bisphosphoglycerate- 2 an L-phenylalanyl- an L-arginyl- an L-aspartyl- an L-histidyl- an L-glutamyl- an L-leucyl- an L-alanyl- an L-lysyl- an L-prolyl- an L-tyrosyl- an L-seryl- an L-tryptophanyl- an L-valyl- an L-isoleucyl- an L-cysteinyl- an L-methionyl- an L-threonyl- an L-asparaginyl- an L-glutaminyl- Glycolysis [iron-sulfur] cluster O c-type a glycyl-[tRNA Gly ] [elongator independent 2-oxobutanoate 2 an L-asparaginyl- [tRNA Phe ] [tRNA Arg ] [tRNA asp ] [tRNA His ] [tRNA Glu ] [tRNA Leu ] [tRNA Ala ] [tRNA Lys ] [tRNA Pro ] [tRNA Tyr ] [tRNA ser ] [tRNA Trp ] [tRNA Val ] [tRNA Ile ] [tRNA Cys ] [initiator tRNA Met ] [tRNA Thr ] [tRNA Asn ] [tRNA Gln ] cytochromea reduced tRNA Met ] phosphoglycerate 2-oxoacid ferredoxin H O c-type [tRNA Asn ] glycolysis I (from 2 mutase: apgM oxidoreductase subunit cytochrome glucose 6-phosphate) beta: NAR_RS0114300 dehypoxanthine an N 3 -methyladenine a tRNA a guanine 34 a nucleoside 6-carboxy-5,6,7,8- an N-terminal- an [RNA]-3'- a [protein]-L- RS0104225 an oxidized [+ 2 isozymes] a polycistronic succinate preQ O-ureido-L- an L-aspartyl- N-formyl- an L-cysteinyl- futalosine SAM in DNA precursor with 1 in tRNA RNA asp Asn tetrahydropterin L-methionyl- Cys ribonucleoside- methionine O c-type D-glucopyranose tRNA precursor triphosphate dITP [tRNA ] [tRNA ] 2 2-oxoacid ferredoxin a 5' extension homoserine 7-carboxy-7- L-glutamate glycyl-[protein] 3'-phosphate peptide- 3-phospho-D-glycerate Asp-tRNA(Asn) RNA 3'- Na + RS0119205 cytochromeNa + 6-phosphate oxidoreductase subunit RdgB/HAM1 family non- methionine Nucleoside and Nucleotide Biosynthesis /Glu-tRNA(Gln) deazaguanine phosphate phosphoglycerate beta: NAR_RS0105685 dehypoxanthine succinyl-CoA synthetase: DNA-3- queuine tRNA- DNA-directed canonical purine NTP synthase QueE: (S)-S-oxide propanoyl-CoA tRNA- RNase P subunit: argininosuccinate amidotransferase: N-formylglutamate type II methionyl peptidyl-tRNA cyclase: rtcA kinase: pgk futalosine NAR_RS0110725 methyladenine ribosyltransferase: RNA polymerase: pyrophosphatase: rdgB NAR_RS0103375 reductase UMP biosynthesis III intron NAR_RS0102405 synthase: gatB gatA amidohydrolase: aminopeptidase: hydrolase: RNA 3'- pyrimidine deoxyribonucleotides de novo biosynthesis I NAR_RS0110730 glycosylase I: NAR_RS0102285 RdgB/HAM1 family non- MsrA: msrA Na + RS0111000 Na + superpathway of inosine-5'-phosphate biosynthesis III phosphoglycerate acyl-CoA thioesterase: lyase: cyclase: mqnC NAR_RS0111580 NAR_RS0118965 7-carboxy-7- NAR_RS0111710 NAR_RS0115410 NAR_RS0119270 Polyprenyl Biosynthesis succinyl-CoA synthetase: NAR_RS0106640 ribonuclease queuine tRNA- canonical purine NTP Asp-tRNA(Asn) phosphate adenosine nucleotides kinase: pgk NAR_RS0112490 endA dehypoxanthine [+ 17 isozymes] deazaguanine N-formylglutamate peptide- UDP CTP NAR_RS0119640 P protein ribosyltransferase: argininosuccinate pyrophosphatase: rdgB /Glu-tRNA(Gln) type II methionyl peptidyl-tRNA an [RNA]-3'-cyclase: rtcA gln de novo biosynthesis I AIR acyl-CoA thioesterase: futalosine DNA-3- synthase QueE: amidohydrolase: methionine hydrogencarbonate adenosylcobalamin- triose- F6P [+ 3 isozymes] NAR_RS0119645 component 4: NAR_RS0112445 synthase: amidotransferase: aminopeptidase: hydrolase: ribonucleoside- trans, trans-farnesyl 13-DPG cyclase: mqnC methyladenine dIMP NAR_RS0116425 (S)-S-oxide + + geranyl diphosphate phosphate NAR_RS0102250 NAR_RS0112265 NAR_RS0111335 gatA gatB NAR_RS0118695 NAR_RS0106855 NAR_RS0110920 2',3'- Na RS0110160 Na IMP 5-(carboxyamino)imidazole dependent ribonucleoside- diphosphate glycosylase I: RNA an L-asparaginyl- 7-carboxy-7- reductase asp CDP biosynthesis isomerase: DHAP fructose 1,6- a 3'-half-tRNA a 5'-half-tRNA a tRNA intron cyclophosphate ribonucleotide synthase: diphosphate reductase: type II propanoate cyclic NAR_RS0115235 a 7-aminomethyl-7- Asn deazaguanine glutamine- biosynthesis molecule with molecule with [tRNA ] MsrA: msrA NAR_RS0121725 NAR_RS0102425 adenosylcobalamin- tpiA glyceraldehyde- bisphosphatase: with a 2',3'-cyclic 5'-deoxyadenosine dehypoxanthine met phosphate succinyl-CoA deazaguanosine 34 an N-terminal a protein-L- hydrolyzing ADP an uncharged guanine canavaninosuccinate formate Cys IPP IPP NAR_RS0109765 a 5'-OH end a 2',3'-cyclic phosphate and a tRNA fragment glu met cys a tRNA methionine- 2+ 2+ carbamoyl- adenylosuccinate 5-(carboxyamino)imidazole [+ 3 isozymes] dependent ribonucleoside- triose- 3-phosphate triose- futalosine an apurinic site tRNA in tRNA glycyl-[protein] Zn RS0102525 Zn dUDP isopentenyl- prenyltransferase: phosphate end a 5'-hydroxyl 3-methyladenine (S)-S-oxide phosphate synthetase: ribonucleotide synthase: diphosphate reductase: phosphate dehydrogenase: phosphate [+ 3 isozymes] within DNA NAR_RS0102425 diphosphate NAR_RS0121045 isomerase: NAR_RS0108465 terminus synthase NAR_RS0101320 NAR_RS0108565 nucleoside-diphosphate isomerase: β Delta-isomerase: prenyltransferase: tpiA -D-fructose 1,6- acetate Nucleoside small kinase: NAR_RS0112970 [+ 3 isozymes] D-glyceraldehyde tpiA 2+ 2+ adenylosuccinate NAR_RS0113575 NAR_RS0109230 DHAP bisphosphate conversion and Nucleotide Zn RS0112155 Zn subunit: carA N5-CAIR geranyl 3-phosphate a guanine 34 N-acetyl-L- a cytidine D-glucopyranose a peptide with a protein-L- synthetase: nucleoside-diphosphate dCDP triose- to acetyl-CoA dethiobiotin a sulfurated a tetrahydrofolate (R)-mevalonate queuine (2E,6E)-farnesyl an N-modified canavaninosuccinate acetyl-CoA isopentenyl- diphosphate Degradation SAM ser in tRNA IPP glutamate 5- 56 in tRNA 3',5'-ADP 6-phosphate an N-terminal methionine- carbamoyl- NAR_RS0118250 5-(carboxyamino)imidazole kinase: NAR_RS0104505 phosphate [sulfur carrier] diphosphate aminoacyl-[tRNA] XTP dGDP nucleoside-diphosphate diphosphate acetate S-methyl-5'- semialdehydeN-acetyl-gamma- tRNA (cytidine(56) 3'(2'),5'-bisphosphate inositol-3- acetyl-CoA L-methionine (R)-S-oxide phosphate isomerase: peptide- 2+ 2+ ribonucleotide mutase: purE dUTP kinase: NAR_RS0112970 Delta-isomerase: acetate--CoA thioadenosine RdgB/HAM1 family non- -2'-O)- nucleotidase CysQ: phosphate carboxylase ribonucleotide- Ca RS0106790 Ca synthase tpiA hydroxymethylglutaryl-CoA queuine tRNA- argininosuccinate glutamyl-phosphate methionine adenylo-succinate superpathway of guanosine 5-(carboxyamino)imidazole dUTPase: NAR_RS0102870 nucleoside-diphosphate NAR_RS0104975 ligase: acs degradation II biotin serine di-trans,poly-cis- canonical purine NTP methyltransferase: NAR_RS0103310 synthase: biotin carboxyl: diphosphate (glutamine- reductase, degradative: ribosyltransferase: peptidyl-tRNA lyase: argH reductase: type II methionyl (R)-S-oxide nucleotides de novo biosynthesis I ribonucleotide mutase: purE dUTPase: NAR_RS0115890 kinase: NAR_RS0104505 DMAPP PRPP biosynthesis acetate--CoA S-methyl-5'- synthase hydroxymethyltransferase: decaprenylcistransferase: pyrophosphatase: rdgB NAR_RS0112430 NAR_RS0107120 NAR_RS0104750 reductase hydrolyzing) NAR_RS0112700 NAR_RS0102285 hydrolase: NAR_RS0118950 3'(2'),5'-bisphosphate aminopeptidase: reductase adenylosuccinate asp D-glyceraldehyde ligase: acs thioadenosine BioB: bioB NAR_RS0103135 uppS argininosuccinate RdgB/HAM1 family non- tRNA (cytidine(56) inositol-3- NAR_RS0104755 subunit beta: : carB carA CAIR dUMP dCTP S-methyl-5'- NAR_RS0119270 N-acetyl-gamma- nucleotidase CysQ: NAR_RS0115410 MsrB: msrB Ca 2+ RS0115340 Ca 2+ lyase: purB prenyltransferase: D-ribose 5- 3-phosphate acetyl-CoA biotin serine hydroxymethylglutaryl-CoA queuine tRNA- di-trans,poly-cis- lyase: argH canonical purine NTP -2'-O)- phosphate NAR_RS0111825 IMP thioadenosine peptidyl-tRNA glutamyl-phosphate NAR_RS0116365 acetyl-CoA type II methionyl thymidylate synthase: NAR_RS0121045 phosphate synthase hydroxymethyltransferase: reductase, degradative: ribosyltransferase: decaprenylcistransferase: pyrophosphatase: rdgB methyltransferase: synthase: [+ 3 isozymes] peptide- ribose-phosphate type II phosphorylase: hydrolase: reductase: carboxylase biotin aminopeptidase: carbamoyl phosphoribosylaminoimidazolesuccinocarboxamide NAR_RS0100205 pyrimidine deoxyribonucleotide phosphorylation prenyltransferase: BioB: bioB NAR_RS0116210 NAR_RS0102060 NAR_RS0112445 uppS XMP NAR_RS0102300 AMP NAR_RS0115620 GDP methionine asp AMP pyrophosphokinase: prs carboxyl carrier 2+ 2+ phosphate IMP dehydrogenase: synthase: purC NAR_RS0109230 glyceraldehyde- NAR_RS0118465 NAR_RS0110920 L-canavanine fumarate NAR_RS0111350 a 2'-O- NAR_RS0106855 (R)-S-oxide Co Co thymidylate synthase: N-acetylglutamyl- 56 protein subunit: CorA guaB dTMP dCMP ribose-phosphate 3-phosphate S-methyl-5'- methylcytidine Ins(3)P reductase Mg 2+ Mg 2+ phosphoribosylaminoimidazolesuccinocarboxamide NAR_RS0107365 geranyl 34 adenylate kinase: pyrophosphokinase: prs dehydrogenase: an unsulfurated a 5,10- + a queuosine di-trans,octa-cis phosphate in tRNA NAR_RS0113300 aspartate IMP dehydrogenase: synthase: purC dTMP kinase: tmk diphosphate thioadenosine biotin 5'-deoxyadenosine met gly HMG-CoA NADH H an uncharged MsrB: msrB NAR_RS0114035 dTMP β-D-fructose 1,6- PRPP NAR_RS0108465 [sulfur carrier] methylenetetrahydrofolate guanine in tRNA -undecaprenyl an N-modified malonyl-CoA a [protein]-L- carbamoyltransferase guaB dTMP kinase: tmk phosphorylase: tRNA met a peptide adenylate kinase: dTDP dCDP prenyltransferase: bisphosphate diphosphate amino acid methionine Co 2+ Co 2+ regulatory subunit: dTMP kinase: tmk NAR_RS0101225 CorA NAR_RS0121045 2+ 2+ NAR_RS0105615 XMP SAICAR dTMP kinase: tmk nucleoside-diphosphate fructose 1,6- 13-DPG 5-MTR-1-P Mg Mg NAR_RS0102550 nucleoside-diphosphate prenyltransferase: kinase: NAR_RS0112970 kinase: NAR_RS0112970 bisphosphatase: [+ 3 isozymes] adenylosuccinate dTDP NAR_RS0109230 + 5 5-amino-4- 5-(2-hydroxyethyl) (2R,3S)-3- succinate a reduced ADP glutamine- NAR_RS0109765 coenzyme M Na N -methyltetrahydromethanopterin PRPP F6P diphosphate H O β 2-oxoglutarate ectoine H O urea 5-aminoimidazole nucleoside-diphosphate nucleoside-diphosphate phosphoglycerate imidazolecarboxyamide 2 -alanine arg 2 -4-methylthiazole isopropylmalate asp L-citrulline semialdehyde factor 420 lyase: purB nucleoside-diphosphate (R)-pantoate GTP ITP dADP 2+ 2+ hydrolyzing GMP ribonucleotide biosynthesis I kinase: NAR_RS0104505 kinase: NAR_RS0104505 (2E,6E)-farnesyl [+ 3 isozymes] kinase: pgk 4-methyl-5(B- 3-isopropylmalate NAD-dependent NADPH- Mg RS0113525 Mg N-carbamoyl- adenosylcobalamin- kinase: NAR_RS0112970 diphosphate pyruvoyl-dependent RdgB/HAM1 family non- synthase: guaA AICAR phosphoglycerate hydroxyethyl) dehydratase: succinate- ribonucleotide- dependent L-aspartate dependent dTTP dCTP F6P tetrahydromethanopterin S- adenine fructose-6- ectoine arginine decarboxylase: urease: canonical purine NTP [+ 2 isozymes] PRPP nucleoside-diphosphate Tetrapyrrole Biosynthesis kinase: pgk C1 Compound Utilization RdgB/HAM1 family -thiazole NAR_RS0114330 argininosuccinate semialdehyde diphosphate F420 ribonucleoside- methyltransferase subunit phosphoribosyltransferase: phosphate phosphopantothenate/ hydroxylase: NAR_RS0110785 GTPase NAR_RS0118405 pyrophosphatase: rdgB formate-- amidophosphoribosyltransferase: kinase: NAR_RS0104505 and Assimilation non-canonical monophosphate leuD leuC leuD dehydrogenase: reductase reductase: 2+ 2+ Cofactor, Carrier, and Vitamin Biosynthesis A: NAR_RS0115895 NAR_RS0118470 aldolase: fsa pantothenate synthetase: thpD arginine decarboxylase, HflX: hflX NAR_RS0118410 synthase: Mg RS0104925 Mg diphosphate GMP phosphoribosylaminoimidazolecarboxamide NAR_RS0122095 dTTP 3-phospho- purine NTP biosynthesis RdgB/HAM1 family non- NAR_RS0102315 subunit beta: npdG tetrapyrrole biosynthesis formaldehyde oxidation NAR_RS0102720 pyruvoyl-dependent: [+ 5 isozymes] ureC 3-isopropylmalate NAR_RS0118965 reductase: ligase: NAR_RS0121480 amidophosphoribosyltransferase: siroheme biosynthesis D-glycerate tetrahydromethanopterin S- adenine fructose-6- pyrophosphatase: ectoine protein: canonical purine NTP NAR_RS0111825 cob(II)yrinate a,c- D-glucopyranose I (from glutamate) VII (THF pathway) phosphopantothenate/ NAR_RS0119550 dehydratase: argininosuccinate NAD-dependent NADPH- (S)-dihydroorotate NAR_RS0102425 formate-- NAR_RS0108150 flavin biosynthesis II (archaea) [2Fe-2S] iron-sulfur adeninyl adenosylcobamide adenosylcobalamin biosynthesis demethylmenaquinol- methyltransferase subunit phosphoribosyltransferase: phosphate rdgB hydroxylase: NAR_RS0112760 pyrophosphatase: rdgB [+ 3 isozymes] 5-phospho-β- diamide biosynthesis I factor 420 biosynthesis I (archaea) 6-phosphate pantothenate synthetase: 4-methyl-5-(2- NAR_RS0105715 synthase: succinate- dependent a metal a metal [+ 3 isozymes] cluster biosynthesis biosynthesis from from adenosylcobinamide-GDP I 8 biosynthesis II 2,3-bisphosphoglycerate- A: NAR_RS0102875 NAR_RS0101220 aldolase: fsa thpD agmatine H + RS0106715 phosphoribosylaminoimidazolecarboxamide adenine salvage (early cobalt insertion) glu uroporphyrinogen-III formaldehyde [+ 5 isozymes] NAR_RS0115740 phosphate ammonium CO IMP leuD leuC leuD NAR_RS0111335 semialdehyde ADP F420 cation cation D-ribosylamine independent GDP 2 phosphooxyethyl) dihydroorotate ligase: NAR_RS0108820 adenosylcobinamide-GDP all-trans- (2S)-2- dehydrogenase: reductase: phosphoribosylamine- ARP glutamate- uroporphyrinogen-III C- phosphoglycerate thiazole dehydrogenase dADP uroporphyrinogen-III GTP L-cysteine desulfurase 5,6-dimethylbenzimidazole 1,4-dihydroxy- octaprenyl D-glyceraldehyde isopropylmalate NAR_RS0112420 npdG -tRNA methyltransferase: cobA + dihydroxyacetone FAICAR -glycine ligase: purD uroporphyrinogen-III mutase: apgM methyl-CoM Na THMPT AICAR + 5-hydroxyectoine succinate electron GDP adenine 6-naphthoate diphosphate ligase: gltX a 5,10- 3-phosphate phosphate H (R)-pantothenate L-arginino- an oxidized a metal a metal phosphoribosylamine- adenine C-methyltransferase: 5-amino-6-(D- an L-glutamyl- uroporphyrinogen-III C- [+ 2 isozymes] succinate RS0105355 transfer subunit: nucleoside- GTP cysteine methylenetetrahydrofolate succinate factor 420 cation cation ribitylamino) [tRNA Glu ] methyltransferase: cobA NAR_RS0111815 diphosphate kinase: -glycine ligase: purD cobA desulfurase: α menaquinone UTP and CTP de cyclohydrolase IIa: uracil--L- -ribazole 5'-phosphate precorrin-1 2-phospho- bifunctional 5,10- [+ 3 isozymes] NAR_RS0112970 nucleoside- adenosylcobalamin- novo biosynthesis uroporphyrinogen-III NAR_RS0112390 sufS biosynthesis glutamyl-tRNA GAR adenine deaminase: adenine tyrosine 4- adenine ribotide D-glycerate methylenetetrahydrofolate pyridin-1-ium-3,5- a DNA containing a uridine 38- an [RNA]-3'- β-D-glucose PRPP nucleoside- diphosphate kinase: dependent C-methyltransferase: [+ 3 isozymes] adenosylcobinamide-GDP decarboxylase: reductase: uroporphyrinogen-III C- a [LarE]-L-cysteine cob(II)alamin PRPP quinolinate a ribonucleoside precorrin-8x superoxide DHAP 2-iminosuccinate agmatine a metal a metal orotate UMP NAR_RS0102150 phosphoribosyltransferase: GTP hydroxyphenyl phosphate dehydrogenase/5,10- dicarboxylate mononucleotide an apurinic/ 40 in tRNA ribonucleoside- 6-phosphate ser a tRNA sec RS0105070 diphosphate kinase: NAR_RS0112970 ribonucleoside- IMP phosphoribosylglycinamide cobA ribazoletransferase: cobS NAR_RS0106555 NAR_RS0104710 methyltransferase: cobA enolase: ATP ATP ATP diphosphate ATP cation cation UMP kinase: pyrH adenine deaminase: NAR_RS0118470 cyclohydrolase IIa: an S-sulfanyl-[L- transferase methenyltetrahydrofolate a tRNA precursor apyrimidinic site selenate tRNA pseudouridine 2',3'- ribonucleotide- precorrin-8X NMN inositol-3- NAR_RS0104505 diphosphate formyltransferase: precorrin-1 adenosylcobinamide-GDP menaquinone [+ 3 isozymes] uroporphyrinogen-III C- NAR_RS0104995 CTP orotate nucleoside- UMP kinase: pyrH NAR_RS0112605 NAR_RS0102345 cysteine desulfurase] CofH: cofH adenosylcobinamide- cyclohydrolase: synthase Pus10: cyclophosphateRNA 2',3'-cyclic diphosphate methylmutase: phosphate reductase: NAR_RS0119690 adenine 2-amino-5- ribazoletransferase: cobS biosynthesis methyltransferase: cobA enolase: ATP-dependent carboxylating superoxide quinolinate agmatinase: phosphoribosyltransferase: diphosphate kinase: UDP uroporphyrinogen-III GDP (S)-4-amino-5- NAR_RS0110695 NAR_RS0106425 phosphodiesterase: reductase NAR_RS0116755 synthase: dATP NAR_RS0102425 phosphoribosylglycinamide phosphoribosyltransferase: formylamino-6- 5-amino-6-(D- decarboxylase: NAR_RS0113595 sacrificial sulfur cob(I)yrinic acid endonuclease III: nicotinate-nucleotide dismutase: synthase speB serine- a metal a metal NAR_RS0113445 NAR_RS0104505 C-methyltransferase: ribazoletransferase: bis(guanylyl molybdopterin) oxopentanoate precorrin-2 CCA tRNA sulfate tRNA pseudouridine thpR subunit beta: precorrin-8X nicotinamide- NAR_RS0107120 RS0115245 nucleoside-diphosphate formyltransferase: NAR_RS0101220 (5-phospho-D- ribitylamino) adenosylcobalamin 5'-phosphate NAR_RS0114985 bifunctional 5,10- transferase LarE: larE a,c-diamide NAR_RS0116505 diphosphorylase: nadC NAR_RS0100385 NadA: nadA agmatinase: -tRNA cation cation orotate [+ 3 isozymes] hypoxanthine cobA uracil--L- cobS cofactor sulfurylation glutamate-1- phosphoenol methylenetetrahydrofolate adenosyltransferase: nucleotidyltransferase: cca adenylyltransferase: sat synthase Pus10: RNA 2',3'-cyclic NAR_RS0111825 methylmutase: nucleotide inositol-3- ligase: kinase: NAR_RS0112970 NAR_RS0110680 ribosylamino) an S-sulfanyl-[cysteine ATP-dependent endonuclease III: carboxylating [+ 3 isozymes] speB phosphoribosyltransferase: uroporphyrinogen-III tyrosine 4- adenosylcobinamide- semialdehyde bifunctional precorrin- pyruvate dehydrogenase/5,10- NAR_RS0121650 CCA tRNA sulfate NAR_RS0114855 phosphodiesterase: NAR_RS0103625 adenylyltransferase: phosphate serS nucleoside-diphosphate pyrimidin- NAR_RS0103520 38- a 2'- [+ 3 isozymes] GTP desulfurase]-[disordered- 2,1- 2 dehydrogenase/ sacrificial sulfur adenylyltransferase: sat nicotinate-nucleotide a pseudouridine an [RNA]-3'- NAR_RS0115810 synthase: NAR_RS0104840 kinase: NAR_RS0104505 FGAR AMP C-methyltransferase: 4(3H)-one hydroxyphenyl GDP cys demethylmenaquinol-8 methenyltetrahydrofolate [+ 3 isozymes] nucleotidyltransferase: cca thpR deoxyribonucleoside hydrogenobyrinate quinolinate a metal a metal dGDP CMP phosphorylation form scaffold aminomutase: sirohydrochlorin phosphoenolpyruvate transferase LarE: larE diphosphorylase: nadC 40 in tRNA ribunucleoside- hydrogen [+ 2 isozymes] NAR_RS0115620 RS0113665 cobA protein] complex transferase ribazoletransferase: cyclohydrolase: 5'-diphosphate O putrescine urea cation cation UTP phosphoribosylformylglycinamidine cysteine hemL ferrochelatase: synthetase: a 3'-terminal a 5'-phospho- 2'-phosphate peroxide 2 an L-seryl- orotidine 5'- CofH: cofH cobS adenosylcobalamin 4-amino-2-methyl-5- NAR_RS0119675 a tRNA adenosine 5'- Ins(3)P precorrin-2 Coα-[α-(adenin- NAR_RS0106300 adenosylcobalamin unsaturated sugar [DNA] [tRNA sec ] phosphate nucleoside- CTP synthase (glutamine synthase: purS purL CMP 5-amino-5-(4- desulfurase: diphosphomethylpyrimidine NAR_RS0109355 pyridin-1-ium-3-carboxylate-5- triphosphate containing a phosphoselenate 2-phospho- 9-yl)]-Coβ- 5-aminolevulinate a 5,10- a [LarE]-dehydroalanine NaMN + diphosphate kinase: hydrolyzing): pyrG phosphoribosylformylglycinamidine 2,5-diamino-6- hydroxybenzyl)- sufS biosynthesis I bifunctional precorrin- thiocarboxylate mononucleotide 3' CCA end NAD IMP bifunctional L-lactate adenosylcobamide methenyltetrahydrofolate a metal RS0113670 a metal orotidine 5'- NAR_RS0112970 CTP synthase (glutamine synthase: purL purQ purS (5-phospho-D- a [cysteine desulfurase]- 6-(D-ribitylimino) [+ 3 isozymes] 2 dehydrogenase/ pyruvate D-ribose RS0118545 D-ribose CDP precorrin-2 5'-phosphate AIR NADP biosynthesis porphobilinogen bifunctional 5,10- cation cation phosphate nucleoside- hydrolyzing): pyrG ribosylamino) S-sulfanyl-[disordered- -5,6-dihydrouracil 2-phospho-L-lactate an [L-cysteine sirohydrochlorin FGAM dehydrogenase/ phosphomethylpyrimidine synthase: hemB methylenetetrahydrofolate decarboxylase: diphosphate kinase: nucleoside-diphosphate pyrimidin- form scaffold 7,8-didemethyl- guanylyltransferase: desulfurase]-S- ferrochelatase: a [protein]-N 6 - a tRNA precursor α-D-glucopyranose a uridine 55 3-deoxy-D-arabino- D-glyceraldehyde an N-terminal D-ribulose L-arginino- D-ribose 5- + L(or D)-O- CTP sirohydrochlorin synthase ThiC: thiC + porphobilinogen dehydrogenase/5,10- NAD a 5-L-glutamyl- coenzyme A a peptide with a ppGpp Asx NAR_RS0101310 NAR_RS0104505 kinase: NAR_RS0112970 4(3H)-one protein] complex 8-hydroxy-5- cofC sulfanyl-L-cysteine thioredoxin NAD NAR_RS0114735 acetyl-L-lysine an amino acid with a 5' CTP 1-phosphate in tRNA heptulosonate 3-phosphate L-alanyl-[S18 5-phosphate succinate a tRNA asp phosphate a metal a metal phosphoribosylformylglycinamidine ferrochelatase: 2,5-diamino-6- cysteine α α cysteine phosphomethylpyrimidine NAD(+)/NADH kinase: synthase: hemB methenyltetrahydrofolate [peptide] leader sequence tRNA pseudouridine ribulose-phosphate phosphoserine RS0113915 orotidine 5'- nucleoside-diphosphate deazariboflavin 2-phospho-L-lactate Co -[ -(adenin- bis(guanylyl pathway extension and a bifunctional (p)ppGpp 7-phosphate3-dehydroquinate type II protein of phosphoserine ribose-5- cation cation cyclo-ligase: NAR_RS0115315 NAR_RS0106300 (ribosylamino)- desulfurase: β desulfurase: synthase ThiC: thiC NAR_RS0105810 sirohydrochlorin Macromolecule Modification cyclohydrolase: synthase Pus10: ribosomal protein 3-epimerase: phosphate dGTP kinase: NAR_RS0104505 synthase subunit guanylyltransferase: 7-yl)]-Co - molybdopterin) porphobilinogen short 3' extension synthetase/guanosine- synthase: glyceraldehyde- 30S ribosome] phosphatase phosphate phosphoribosylformylglycinamidine 4(3H)-pyrimidinone sufS sufS an oxidized HMP-P NAR_RS0110695 NAD-dependent CoA pyrophosphatase: glucose-1-phosphate NAR_RS0106425 S18-alanine N- NAR_RS0113505 argininosuccinate decarboxylase: bifunctional CofG: cofG cofC adenosylcobamide cofactor NAD(+)/NADH kinase: gamma- signal peptidase I: 3',5'-bis(diphosphate) 3'- NAR_RS0114970 3-phosphate aspartate-- SerB: serB isomerase cyclo-ligase: NAR_RS0106735 CTP 5'-phosphate [+ 3 isozymes] thioredoxin hydroxymethylbilane bifunctional precorrin- N 6 -L-threonylcarbamoyladenosine 37 deacylase: NAR_RS0111295 cytidylyltransferase: acetyltransferase: lyase: argH NAR_RS0118260 precorrin-2 an S-sulfanyl-[cysteine 7,8-didemethyl- L-lactyl-2- [+ 3 isozymes] bifunctional NAR_RS0114425 bifunctional 5,10- glutamyltransferase: ggt RNase P subunit: NAR_RS0112840 tRNA pseudouridine pyrophosphohydrolase: dehydrogenase: ribulose-phosphate tRNA(Asn) phosphoserine RpiA: rpiA a metal a metal reductase: + 2 dehydrogenase/ NAR_RS0116125 NAR_RS0103965 3-dehydroquinate RS0105065 AIR dehydrogenase/ 8-hydroxy-5- diphospho- a [bis(guanylyl NADP synthase: hemC -modified tRNA biosynthesis methylenetetrahydrofolate CoA pyrophosphatase: synthase Pus10: NAR_RS0113085 NAR_RS0108465 rimI 3-epimerase: argininosuccinate ribose-5- cation cation NAR_RS0112400 desulfurase]-S- hydroxymethylpyrimidine sirohydrochlorin gamma- NAR_RS0102405 signal peptidase I: synthase: an N-terminal N ligase: aspS phosphatase UMP sirohydrochlorin deazariboflavin 5'-guanosine molybdopterin) hydroxymethylbilane dehydrogenase/5,10- NAD-dependent NAR_RS0119010 glucose-1-phosphate NAR_RS0114855 [+ 2 isozymes] NAR_RS0104900 lyase: argH phosphate sulfanyl-[disordered- thioredoxin- kinase/ glutamyltransferase: ggt [+ 3 isozymes] NAR_RS0104380 55 13-DPG [+ 3 isozymes] SerB: serB 2,5-diamino-6- cofactor [bis-MGD cofactor synthase: hemC ferrochelatase: deacylase: cytidylyltransferase: a pseudouridine GDP NAR_RS0106540 -acetyl-L-alanyl- D-xylulose ferrochelatase: form scaffold disulfide phosphomethylpyrimidine thr methenyltetrahydrofolate isomerase (ribosylamino)- 2-phospho-L- chaperone]-S- chaperone]- NAR_RS0106300 NAR_RS0103050 rfbF in tRNA 3-dehydroquinate [S18 protein of 5-phosphate serine NAR_RS0114735 protein] complex adenosylcobalamin reductase: kinase: thiD threonylcarbamoyl- cyclohydrolase: an α-(5-L- RpiA: rpiA a metal a metal 4(3H)-pyrimidinone lactate transferase: sulfanyl-L-cysteine bis-MGD preuroporphyrinogen bifunctional precorrin- a tRNA precursor 3',5'-ADP 4'-phosphopantetheine 30S ribosome] arg fumarate an L-aspartyl- D-ribulose RS0106650 D-ribulose salvage from cobalamin trxB AMP synthase: NAR_RS0119675 glutamyl)- a peptide with a short a tRNA fragment a leader sequence a peptide cation cation sirohydrochlorin 5'-phosphate NAR_RS0115490 2 dehydrogenase/ 2''-O-acetyl- α [tRNA Asx ] 5-phosphate HMP-PP uroporphyrinogen- NAR_RS0101360 10 CDP- -D-glucose Amino Acid Biosynthesis 5-phosphate reductase: thioredoxin- an N - nicotinamide a [protein]-L-lysine amino acid 3' extension 2-phospho-L- cob(I)alamin III synthase: sirohydrochlorin threonylcarbamoyl- ADP-ribose sirohydrochlorin NAR_RS0102335 a [cysteine disulfide formyltetrahydrofolate Fatty Acid and Lipid Biosynthesis 3,4- 2,5-diamino-6- lactate transferase: NAR_RS0106190 ferrochelatase: AMP synthase: L-histidine biosynthesis cobaltochelatase: dihydroxy-2- desulfurase]-(S- sulfo-bis(guanylyl reductase: pyridoxal 5'-phosphate biosynthesis II NAR_RS0114735 formyltetrahydrofolate L-isoleucine L-leucine biosynthesis L-tryptophan biosynthesis L-phenylalanine NAR_RS0116760 (5-phospho- NAR_RS0106930 uroporphyrinogen- NAR_RS0118215 diphthamide butanone-4- sulfanyl) -[disordered- molybdopterin) trxB (L-threonylcarbamoyl) deformylase: 3-methyl-2- a 5,10- (7,8-dihydropterin- a 2'- a uridine 65 a double 4-hydroxy-3- 7-carboxy-7- a [protein]- biosynthesis I biosynthesis I D-ribitylamino) 2 2-methylbutanoate a uracil in DNA APS biosynthesis I (archaea) biotin-carboxyl carrier sirohydrochlorin phosphate form scaffold cob(II)alamin cofactor III synthase: siroheme adenylate NAR_RS0112940 oxobutanoate methylenetetrahydrofolate 6-yl)methyl 4-aminobenzoate a tRNA precursor deoxyribonucleoside [DNA] in tRNA stranded DNA octaprenylbenzoate 13-DPG thr deazaguanine L-tyrosine PRPP (from threonine) 3-methyl-2- acyl-CoA hydrolysis pyrimidin- oxidized aldehydo-D-ribose D-glyceraldehyde gln GTP ATP an L-histidine- protein assembly cobaltochelatase: synthase: protein] complex NAR_RS0114630 tRNA (adenosine(37)-N6)- formyltetrahydrofolate diphosphate 5'-triphosphate tRNA pseudouridine DNA topoisomerase UbiD family 7-cyano-7- phosphate adenylyl-sulfate oxobutanoate gln chorismate 4(3H)-one factor 420-0 cob(I)yrinic acid a reduced 5-phosphate 3-phosphate type II threonine protein-tyrosine- 2-isopropylmalate [translation a [biotin a 2,3,4-saturated NAR_RS0103630 ribB threonylcarbamoyltransferase deformylase: synthase Pus10: VI subunit B: decarboxylase: glyceraldehyde- adenylate/guanylate adenylate/guanylate deazaguanine kinase: cysC ATP thr chorismate a,c-diamide thioredoxin uroporphyrinogen-III 3-methyl-2-oxobutanoate acetate--CoA uracil-DNA ammonia-lyase: phosphatase: synthase: elongation factor 2] carboxyl-carrier fatty acyl CoA cobalt- complex transferase NAR_RS0104475 dihydropteroate DNA: NAR_RS0106425 NAR_RS0118310 NAR_RS0102255 3-phosphate cyclase domain- cyclase domain- synthase: adenylyl-sulfate phosphoribosyltransferase: threonine anthranilate synthase: diphthamide mutase: pheA acyl-CoA 3,4- adenosyltransferase: pyridoxal 5'- hydroxymethyltransferase: ligase: acs ribonuclease Z: rnz glycosylase: NAR_RS0121715 NAR_RS0102950 hisG NAR_RS0111375 biosynthesis protein]-L-lysine sirohydrochlorin subunit TsaD: tsaD synthase: NAR_RS0103140 tRNA pseudouridine DNA topoisomerase UbiD family dehydrogenase: containing protein: containing protein: NAR_RS0103390 kinase: cysC ammonia-lyase: NAR_RS0109075 prephenate thioesterase: dihydroxy-2- 5-amino-6-(5- a [cysteine desulfurase]- NAR_RS0121650 phosphate Amine and Polyamine formate panB acetate--CoA ribonuclease Z: rnz NAR_RS0110420 threonine protein-tyrosine- [+ 4 isozymes] enzyme biotin--[acetyl-CoA- an oxidized 5-methylbenzimidazolyl tRNA (adenosine(37)-N6)- NAR_RS0119000 NAR_RS0103175 synthase Pus10: VI subunit B: decarboxylase: NAR_RS0108465 NAR_RS0102985 NAR_RS0102985 7-cyano-7- PAPS ATP NAR_RS0121715 (2S)-2- NAR_RS0102250 butanone-4- phospho-D- [scaffold protein- [+ 3 isozymes] synthase: Biosynthesis 3-methyl-2-oxobutanoate ligase: acs [+ 3 isozymes] D-glyceraldehyde ammonia-lyase: phosphatase: Dph2: dph2 carboxylase] ligase: factor 420 adenosylcobamide biosynthesis threonylcarbamoyltransferase [+ 3 isozymes] [+ 5 isozymes] NAR_RS0114855 NAR_RS0101260 NAR_RS0112485 [+ 6 isozymes] [+ 6 isozymes] deazaguanine phosphoribosyltransferase: threonine isopropylmalate anthranilate PRPP prephenate phosphate (2Fe-2S)] complex cob(II)alamin- pdxT pdxS hydroxymethyltransferase: a pseudouridine 65 a negatively NAR_RS0108575 NAR_RS0115990 NAR_RS0120550 acyl-CoA ribitylamino)uracil from adenosylcobinamide-GDP Aromatic Compound 2-octaprenylphenol 3-phosphate cyclic-GMP cyclic-AMP synthase: a [protein]- hisG ammonia-lyase: diphthamide dehydratase: synthase: [corrinoid ectoine biosynthesis complex transferase panB a single-stranded in tRNA supercoiled DNA 2-oxobutanoate 3-isopropylmalate biotin--[acetyl-CoA- thioesterase: cobalt-factor III 5-methylbenzimidazole 4-aminobenzoate pyridoxal 5'- Biosynthesis subunit TsaD: tsaD (2S)-2- mature tRNA oligoribonucleotide an apyrimidinic uracil NAR_RS0116440 L-tyrosine NAR_RS0108575 dehydratase: biosynthesis pheA NAR_RS0112490 ribB adenosyltranferase] biosynthesis phosphate Amino Acid Degradation diphosphate 7,8- 1-(5-phospho-β-D-ribosyl)-ATP (2Z)-2-aminobut- anthranilate carboxylase] ligase: a 2,3,4-saturated an N 6 -L- methylbutanoyl-CoA AMP [DNA] site in DNA preQ enzyme prephenate 1-deoxy-L- a [co-chaperone]- a reduced chorismate biosynthesis dihydropteroate 0 2-enoate NAR_RS0105715 phosphoribosyltransferase: trpD NAR_RS0109550 synthase: asp 37 a 2-[(3S)-3-amino-Dph2: dph2 dehydratase: fatty acid glycero-tetrulose from 3-dehydroquinate threonylcarbamoyladenine 2-dehydropantoate a tetrahydrofolate leuD leuC leuD anthranilate a [biotin carboxyl- ARP [scaffold protein- factor 420 5-methylbenzimidazole chorismate pdxS pdxT aspartate kinase: L-methionine degradation 3-carboxypropyl]-L- pheA 4-phosphate in tRNA 3-isopropylmalate phosphoribosyltransferase: trpD carrier protein]-N (2Fe-2S)] complex cob(I)alamin- ribotide phosphate aminodeoxychorismate/ NAR_RS0117120 I (to L-homocysteine) histidine-[translation 6 3-dehydroquinate dehydratase: 3-phenyl-2- -biotinyl-L-lysine cobalt-precorrin-3 [corrinoid anthranilate synthase [+ 3 isozymes] elongation factor 2] 6,7-dimethyl-8- adenosylcobinamide- PLP a 2'- 32 N-acetyl-D- 1-(5-phospho-β-D-ribosyl)-AMP NAR_RS0114330 oxopropanoate adenosyltranferase] component II: type I 3- L-aspartyl- 7,8- an [eIF5A- an (S)-2- a uridine 4-hydroxybutanoyl- a [protein]-L- (2Z,4E)-2- 2-iminobutanoate N-(5-phosphoribosyl)-anthranilate ribityllumazine GDP met pyruvate spermidine deoxyribonucleoside DHAP an adenine in DNA mannosamine an L-glutamyl- cob(I)yrinic acid NAR_RS0121190 dehydroquinate 4-phosphate dihydroneopterin precursor]-lysine halocarboxylate [DNA] in tRNA CoA β-isoaspartate Gln hydroxyhexa- asp asp leuD leuC leuD a [chaperone-ATP]- archaeosine methionine [tRNA ] phosphoribosyl-AMP long-chain fatty synthase: a,c-diamide ribazoletransferase: dehydratase: aroD 3'-triphosphate 5'-triphosphate 3-hydroxy-5- tRNA pseudouridine DNA adenine 4-hydroxybutyryl- 6-phosphateN-acylneuraminate- protein-L- 2,4-dienedioate a [biotin carboxyl- [co-chaperone]- aminodeoxychorismate/ biosynthesis I adenosyltransferase: Asp-tRNA(Asn) 4-oxalocrotonate aspartate aspartate cyclohydrolase: hisI 2-isopropylmaleate acid activation NAR_RS0112385 adenosyltransferase: cobS type I 3- aspartate- phosphonooxypentane- synthase Pus10: methylase: CoA dehydratase: 9-phosphate isoaspartate(D- a diphthine-[translation carrier-protein [scaffold protein- anthranilate synthase NAR_RS0116780 pyruvate, phosphate deoxyhypusine HAD family /Glu-tRNA(Gln) tautomerase: dehydrogenase: ammonia-lyase: phosphoribosyl-AMP cobalt-precorrin-4 6,7-dimethyl-8- NAR_RS0121650 adenosylcobinamide- dehydroquinate semialdehyde DNA: 2,4-dione thiolase: lsrF NAR_RS0106425 NAR_RS0101695 NAR_RS0112830 synthase: aspartate) O- elongation factor 2] dimer]-N 6 - (2Fe-2S)] complex component II: preQ dikinase: NAR_RS0120845 6-pyruvoyltetrahydropterin synthase: hydrolase: amidotransferase: NAR_RS0102465 NAR_RS0119155 NAR_RS0119035 cyclohydrolase: hisI 3-isopropylmalate 1-(2-carboxyphenylamino)-1- phe a long-chain ribityllumazine dehydrogenase: 0 methionine 3-hydroxy-5- tRNA pseudouridine DNA adenine 4-hydroxybutyryl- methyltransferase: 2-oxobutanoate biotinyl-L-lysine [+ 3 isozymes] GDP NAR_RS0109080 cytidylyl molybdenum dehydratase: aroD tRNA synthase: NAR_RS0101490 NAR_RS0107115 NAR_RS0103945 NAR_RS0103140 N-acetyl-β-NAR_RS0104000 gatB gatA 4-oxalocrotonate aspartate aspartate 1-(5-phospho-β-D-ribosyl)- dehydratase: deoxy-D-ribulose 5-phosphate diphthine-- fatty acid synthase: adenosylcob(III) 4-amino-4- 3-dehydroshikimate asd adenosyltransferase: pyruvate, phosphate phosphonooxypentane- synthase Pus10: methylase: CoA dehydratase: NAR_RS22715 acetyl-CoA acyl-CoA ribazoletransferase: cofactor sulfurylation guanosine(15) 6-pyruvoyltetrahydropterin NAR_RS0103175 neuraminate a protein L-β- [+ 3 isozymes] tautomerase: dehydrogenase: ammonia-lyase: 5-[(5-phosphoribosylamino) acetolactate NAR_RS0105715 ammonia ligase: synthetase: NAR_RS0102350 alamin-[corrinoid cobS deoxychorismate aspartate- NAR_RS0103650 dikinase: NAR_RS0109355 [+ 3 isozymes] 2,4-dione thiolase: lsrF NAR_RS0114855 NAR_RS0117695 NAR_RS0104370 an L-glutaminyl- indole-3-glycerol- carboxylase biotin transglycosylase synthase: NAR_RS0117975 [+ 5 isozymes] 32 6 9-phosphate isoaspartate shikimate 3-hydroxy-2,4- a pseudouridine an N -methyladenine Gln NAR_RS0112210 NAR_RS0111080 NAR_RS0111270 methylideneamino]imidazole- synthase leuD leuC leuD NAR_RS0114845 NAR_RS0111445 adenosyltranferase] Coα-[α-(5- cytidylyl molybdenum semialdehyde SAM an (S)-2- α [tRNA ] (3E)-2-oxohex- phosphate synthase: carboxylase subunit: cobalt- a [chaperone- TgtA: tgtA a halide anion dioxopentyl crotonyl-CoA -methyl ester oxaloacetate fumarate 4-carboxamide large subunit: 3-isopropylmalate diphthine-- 6,7-dimethyl-8-(1- an [2Fe-2S] coenzyme A biosynthesis cob(I)yrinic acid methylbenzimidazolyl)]- cofactor (trioxo) dehydrogenase: aroE dehydrogenase: propane- an [eIF5A- hydroxycarboxylate in tRNA in DNA 3-enedioate NAR_RS0121180 L-serine biosynthesis I NAR_RS0104750 a long-chain[+ 2 isozymes] precorrin-5A ADP]-[disordered- tRNA phosphoenolpyruvate H + (6R)-6-pyruvoyl- phosphate 1-(5-phosphoribosyl)-5- NAR_RS0109865 dehydratase: ammonia ligase: a [carboxyl-carrier D-ribityl)lumazine cluster protein I (prokaryotic) a,c-diamide Coβ-adenosylcobamide shikimate asd diphosphate 1,3-diamine precursor]- [DNA] indole-3-glycerol- fatty acyl-CoA form scaffold guanosine(15) AMP 5,6,7,8- triphosphate [(5- phosphoribosylamino) 6 5'-phosphate dehydrogenase: aroE deoxyhypusine [+ 2 isozymes] NAR_RS0114330 phosphate synthase: NAR_RS0106415 protein dimer]-N riboflavin synthase: protein] complex (R)-4'- adenosyltransferase: 4-aminobenzoate an [MCD cofactor L-aspartate 4- tetrahydropterin methylideneamino]imidazole-4- a diphthamide- 3-phospho- transglycosylase (S)-2-aceto-2- leuD leuC leuD NAR_RS0109090 -carboxybiotinyl- NAR_RS0112375 phosphopantothenate NAR_RS0121650 chaperone]-MCD semialdehyde carboxamide isomerase: hisA [translation D-glycerate cobalt- bifunctional shikimate preQ atTgtA: tgtA hydroxybutanoate (2R,3S)-3- L-lysine riboflavin synthase: [+ 3 isozymes] cysteine 0 SAH (1S,2R)-1-C-(indol-3- elongation factor 2] precorrin-5B phosphopantothenoylcysteine α α diaminobutyrate- position 15 of a 3,5,7,9,11,13,15- GDP-α-D- 1-(5-phosphoribosyl)-5- ketol-acid isopropylmalate NAR_RS0102360 Co -[ -(5- desulfurase: shikimate kinase: a proteinogenic an (S)-2- (2E,6E)-farnesyl 2-phosphoglycolate adenosyl-cob(III) pyridoxamine precorrin-6B a negatively DNA with lesion UDP yl)glycerol 3-phosphate an [Fe-S cluster decarboxylase/ adenosylcobalamin -2-oxoglutarate an archaeal tRNA adenosylhomocysteinase: a 5-methyltetrahydrofolate L-homocysteine leukotriene-C4 isobutanoate protoheme hepta-oxo- mannose [(5- phosphoribosylamino) reductoisomerase: 3-phosphooxypyruvate cobalt-precorrin- methylbenzimidazolyl)]- sufS NAR_RS0106525 amino acid halocarboxylate diphosphate GTP yrinate a,c-diamide 5'-phosphate supercoiled DNA ribonucleotide- riboflavin biosynthesis phosphopantothenate-- β transaminase: ectB NAR_RS0120690 hexadecanoyl-[PKS-acp] phosphoglycolate cobyric acid pyridoxamine 5'- precorrin-6Y C5,15- DNA excinuclease GDP-mannose methylideneamino]imidazole-4- ilvC tryptophan synthase: 5B (C(1))- Co -adenosylcobamide factor 420 [+ 3 isozymes] aldo/keto diphosphate chaperone]-ATP cysteine ligase CoaBC: coaBC diaminobutyrate- adenosylhomocysteinase: reductase: bifunctional (p)ppGpp phosphatase: synthase: phosphate oxidase: methyltransferase topoisomerase: ABC subunit C: dehydrogenase: carboxamide isomerase: hisA ketol-acid NAR_RS0121170 trpB methyltransferase: polyglutamylation a [cytidylyl molybdenum shikimate 3-phosphate HAD family reductase (2S)-2-isopropyl- -2-oxoglutarate archaeosine at NAR_RS0109435 methionine synthase: gamma- acetate--CoA ligase: acs protoheme IX NAR_RS0121050 synthetase/guanosine- NAR_RS0107290 NAR_RS0102180 NAR_RS0120925 (decarboxylating) NAR_RS0102455 NAR_RS0110620 NAR_RS0116820 phosphoribulosylformimino- reductoisomerase: tryptophan synthase: NAR_RS0116770 bifunctional cofactor chaperone]- S-adenosyl- hydrolase: subunit beta: 3-oxosuccinate oxidized 3-phosphoshikimate 1- transaminase: ectB position 15 of NAR_RS0118995 glutamyltransferase: ggt acetate--CoA ligase: acs farnesyltransferase: 3',5'-bis(diphosphate) 3'- phosphoglycolate cobyric acid [+ 2 isozymes] subunit CbiT: cbiT [+ 6 isozymes] excinuclease GDP-mannose AICAR-phosphate ilvC trpB NAR_RS0109100 L-homoserine cobalt-precorrin- phosphopantothenate phosphopantothenoylcysteine cytidylyl molybdenum L-methionine NAR_RS0103945 9-hydroxy-3,5,7,11,13,15-[+ 3 isozymes] NAR_RS0111825 O-phospho- factor 420-0 carboxyvinyltransferase: an archaeal tRNA L-homocysteine methionine synthase: cyoE pyrophosphohydrolase: phosphatase: synthase: [+ 3 isozymes] a relaxed DNA ABC: uvrB uvrA dehydrogenase: biosynthesis 5B (C(1))- biosynthesis III (archaebacteria) decarboxylase/ dipyrromethane coenzyme cofactor (sulfo-dioxo) biosynthesis L-2,4- gamma- hexaoxohexadecanoyl- PLP (R)-2,3-dihydroxy- indole ser L-serine FMN biotin biosynthesis from aroA NAR_RS0111310 [+ 3 isozymes] NAR_RS0113085 NAR_RS0100885 NAR_RS0112575 precorrin-8x NAR_RS0119755 NAR_RS0103685 [+ 3 isozymes] methyltransferase: phosphopantothenate-- cofactor biosynthesis F420-0:L- diaminobutanoate glutamyltransferase: ggt [PKS-acp] GDP-α-D- imidazole glycerol 3-methylpentanoate phosphoserine 8-amino-7-oxononanoate I met isobutanoyl-CoA a (2R)-2- pppGpp DNA without dUDP NAR_RS0103640 3-methyl-2-oxobutanoate (R)-4'- cysteine ligase CoaBC: coaBC glutamate 3-phosphoshikimate 1- diphosphate a halide anion glycolate adenosylcobyrate mannuronate phosphate dihydroxy-acid 4-methyl-2- asp phosphatase an apo- methionine diaminobutyrate AMP hydroxy fatty acid lesion tryptophan synthase: 3-methyl-2-oxobutanoate phosphopantothenoyl- ligase: cofE carboxyvinyltransferase: a tetrahydrofolate α γ synthase: hisH hisF dehydratase: oxopentanoate aspartate kinase: SerB: serB cobalt- [hydroxymethylbilane (8S)-8-amino-7-oxononanoate adenosyltransferase: acetyltransferase: NADH repair (eukaryotes) met an -( -L-glutamyl) ferroheme o NAR_RS0121170 trpB hydroxymethyltransferase: L-cysteine aroA leukotriene-D4 imidazole glycerol ilvD branched-chain NAR_RS0117120 precorrin-6A synthase]-L-cysteine adenosylmethionine--8- coenzyme NAR_RS0116780 ectA L-citrulline degradation -L-amino acid tryptophan synthase: phosphoserine FAD panB bifunctional F420-0:L- 5-enolpyruvoyl- phosphate dihydroxy-acid amino acid [+ 3 isozymes] amino-7-oxononanoate diaminobutyrate trpB NAR_RS0109100 L-aspartyl- phosphatase 3-methyl-2-oxobutanoate phosphopantothenoylcysteine a [hydroxymethylbilane glutamate methionine shikimate 3-phosphate NADH synthase: hisF hisH transaminase: transaminase: bioA acetyltransferase: 2503 dehydratase: 4-phosphate SerB: serB synthase] ES adenosyltransferase: L-citrulline adenine an (R)-2- adenine 1518 / UDP-N-acetyl- dCDP NAR_RS0117110 hydroxymethyltransferase: decarboxylase/ 2 ligase: cofE a proteinogenic glutathione [DNA] carbamoyl pyridoxine histidinol precorrin-3B ilvD adenosylmethionine--8- oxidized chorismate ectA L-ornithine 1519 L-homocysteine α-D-glucosamine glu cobalt- panB phosphopantothenate-- intermediate NAR_RS0103650 ornithine in 23S rRNA halocarboxylate adenine in 16S rRNA ATP 5'-phosphate glu [+ 2 isozymes] aspartate- ser hydroxymethylbilane amino-7-oxononanoate factor 420-1 synthase: aroC amino acid phosphate ribosomal RNA UDP-N- histidinol precorrin-3B C(17)- ribonucleotide- AICAR D-erythro-1-(imidazol-4- (3S)-3-methyl-2- trp precorrin-6B 2-dehydropantoate cysteine ligase CoaBC: coaBC SAM (2S)-4-acetamido- carbamoyltransferase: methionine synthase: pyridoxamine 5'- glutamate racemase: semialdehyde synthase: hemC transaminase: bioA hydroxymethylpyrimidine chorismate small subunit acetylglucosamine dehydrogenase: hisD methyltransferase: gamma- diphosphate yl)-glycerol 3-phosphate oxopentanoate thiamine diphosphate 2-aminobutanoate argF Dna2/Cas4 domain- HAD family NAR_RS0118995 sulfate phosphate oxidase: NAR_RS0116550 leu dehydrogenase: bifunctional (7R,8S)-diaminononanoate salvage synthase: aroC 23S rRNA methyltransferase 2-epimerase (non- NAR_RS0116765 glutamyl kinase: reductase imidazoleglycerol- branched-chain L-valine biosynthesis biosynthesis hydroxymethylbilane ectoine (R)-NADHX carbamoyl phosphate gamma- containing protein: hydrolase: ornithine methionine synthase: adenylyltransferase: sat NAR_RS0120925 histidinol glutamate racemase: asd phosphopantothenoylcysteine (adenine(2503)-C(2) A: rsmA hydrolyzing): NAR_RS0104980 subunit beta: phosphate amino acid II (Bacillus) synthase: hemC 4-amino-2-methyl-5- synthase: glutamyltransferase: ggt carbamoyltransferase: N 6 -dimethyladenine 1518 NAR_RS0111310 sulfate [+ 2 isozymes] dehydrogenase: hisD [+ 3 isozymes] NAR_RS0103480 decarboxylase/ a [hydroxymethylbilane dethiobiotin synthase: bioD oxidized chorismate NAD(P)H-hydrate )-methyltransferase NAR_RS0102620 NAR_RS0103945 NAR_RS0117345 γ-L-glutamyl NAR_RS0111825 dehydratase: transaminase: aspartate- cobalt-precorrin-7 pyrimidinemethanol ectC glutamine-hydrolyzing gamma- argF /N 6 -dimethyladenine 1519 adenylyltransferase: sat PLP precorrin-4 pyruvate HMP-PP phosphopantothenate-- synthase] ES dethiobiotin synthase: bioD factor 420-2 bifunctional epimerase: RlmN: rlmN met his D-glt 5-phosphate [+ 3 isozymes] semialdehyde (R)-pantoate 3 carbamoyl-phosphate APS [+ 2 isozymes] NAR_RS0102030 NAR_RS0117110 L-threonine cysteine ligase CoaBC: coaBC hydroxymethylpyrimidine ectoine NAR_RS0113615 glutamyltransferase: ggt a 2'- in 16S rRNA UDP-N-acetyl-α- acetolactate dehydrogenase: intermediate synthase small a (2R)-2- CDP imidazoleglycerol- [+ 2 isozymes] biosynthesis hydroxymethylbilane dethiobiotin kinase/ synthase: NAD(P)H-hydrate deoxyribonucleoside [DNA] a halide anion D-mannosamine synthase asd subunit: carA a 2-methyladenine 2503 hydroxy fatty acid phosphate large subunit: thiamine 4'-phosphopantetheine synthase: hemC phosphomethylpyrimidine ectC epimerase: 5'-deoxyadenosine met an α-(γ-L-glutamyl) 3'-monophosphate L-citrulline ile L-aspartate 4- biotin synthase BioB: bioB carbamoyl-phosphate in 23S rRNA L-cysteinylglycine dehydratase: L-homoserine NAR_RS0109865 cobalt-precorrin-8 phosphate hydroxymethylbilane kinase: thiD ectoine (S)-NADHX NAR_RS0105015 -L-amino acid semialdehyde pantetheine- biotin synthase BioB: bioB synthase (glutamine- NAR_RS0112725 homoserine kinase: [+ 2 isozymes] thiamine- (R)-4-phosphopantoate synthase: hemC HMP-P phosphate a [hydroxymethylbilane NAD(P)H-hydrate hydrolyzing): carB carA 3-(imidazol-4-yl)-2- NAR_RS0116445 (S)-2-acetolactate homoserine phosphate adenylyltransferase: synthase] ES 9-mercaptodethiobiotin bifunctional dehydratase: an N 10 - an (R)-2- nicotinate adenine a [protein]- homoserine kinase: dehydrogenase: phosphopantothenate/ 4 an L-methionyl- a ribonucleoside D-ribofuranose oxopropyl phosphate kinase: thiL NAR_RS0117745 carbamate hypoglycin A glutathione a uridine in tRNA a single precorrin-4 his a [protein] Ser/Thr a DNA segment NADH D-glycerate a protein ketol-acid pantothenate synthetase: intermediate hydroxymethylpyrimidine NAR_RS0100170 [initiator tRNA Met ] formyltetrahydrofolate halocarboxylate triphosphate dinucleotide L-tyrosine NAR_RS0103395 NAR_RS0107355 thiamine- biotin synthase BioB: bioB tRNA dihydrouridine stranded DNA precorrin-4 C(11)- serine/threonine recombinase RecA: NAD+ synthase: NAD(+)/NADH kinase: ribokinase: histidinol-phosphate O-phospho- reductoisomerase: NAR_RS0102720 3'-dephospho- hydroxymethylbilane kinase/ NAD(P)H-hydrate L-histidine N(alpha)- D-glycerate TrkA-N domain- proteasome L-glutamine homoserine cobyrinate phosphate biotin synthase BioB: bioB synthase DusB: dusB methyltransferase: cobM protein kinase: NAR_RS0121620 NAR_RS0120675 NAR_RS0105810 NAR_RS0121150 transaminase: hisC L-homoserine ilvC CoA synthase: hemC phosphomethylpyrimidine dehydratase: methyltransferase: egtD dehydrogenase: containing protein: subunit beta: biosynthesis I dehydrogenase: kinase: thiL phosphopantothenate/ HAD family NAR_RS0103080 recombinase RecA: ribokinase: histidinol-phosphate threonine hydroxymethylbilane kinase: thiD NAR_RS0107330 methionyl-tRNA gamma- tRNA dihydrouridine DNA primase: precorrin-4 C(11)- L-histidine N(alpha)- NAD+ synthase: NAD(+)/NADH kinase: NAR_RS0114285 NAR_RS0105900 NAR_RS0100185 ketol-acid NAR_RS0100195 pantothenate synthetase: biotin hydrolase: NAR_RS0108680 NAR_RS0109140 a [protein]- transaminase: hisC synthase: thrC thiamine synthase: hemC CO formyltransferase: glutamyltransferase: ggt synthase DusB: dusB NAR_RS0111410 methyltransferase: cobM methyltransferase: egtD [+ 3 isozymes] a DNA segment NAR_RS0109445 NAR_RS0114425 [+ 7 isozymes] reductoisomerase: NAR_RS0115740 2 NAR_RS0103945 hydroxypyruvate D-ribofuranose glu diphosphate a holo- HMP-PP NADH NAR_RS0104015 a 5,6-dihydrouridine in tRNA [+ 4 isozymes] precorrin-5 a [protein] (L-serine/L- NAD + NADPH L-tyrosine [+ 2 isozymes] ilvC L-homoserine cob(II)yrinate gamma- hercynine in reverse 5-phosphate a peptide L-histidinol phosphate type I (2R)-2,3- (R)-4'-phosphopantothenate coenzyme A [hydroxymethylbilane glutamyltransferase: ggt threonine) phosphate orientation phosphate glutamate- a,c-diamide synthase] an (S)-2- thr dihydroxy-3- an N-formyl- a halide anion -ammonia hydroxycarboxylate ssDNA/pppN(pN) methylbutanoate L-methionyl- a tetrahydrofolate hybrid ligase: glnA n -1 dihydroxy-acid L-proline [initiator tRNA met ] hypoglycin B L-cysteinylglycine [+ 3 isozymes] dehydratase: degradation I histidinol gln ilvD histidinol pro pyridin-1-ium-3-carboxylate-5- 4a-hydroxy-N 10 - a single (2S)- γ-glutamyl- a supercoiled a [protein]- dihydroxy-acid a [LarE]-L-cysteine glycyl-glycine glutathione N-methylhydantoin precorrin-2 citrate a cytosine in DNA an aliphatic amine D-glycerate dehydrogenase: hisD dehydratase: proline thiocarboxylate mononucleotide formyltetrahydrofolate stranded DNA an acyl phosphate ethylmalonyl-CoA isopropylamide duplex DNA L-histidine histidinol ilvD dehydrogenase: 4a-hydroxytetrahydrobiopterin deoxyribonuclease N-methylhydantoinase: precorrin-2 C(20)- aconitate hydratase: DNA (cytosine-5-)- acylphosphatase: copper amine methylmalonyl- D-glycerate ATP-dependent histidine kinase: ferredoxin: dehydrogenase: hisD NAR_RS0117855 dehydratase: IV: NAR_RS0116665 NAR_RS0120360 methyltransferase: cobI NAR_RS0101575 methyltransferase: NAR_RS0116890 oxidase: CoA epimerase: dehydrogenase: helicase: NAR_RS0120590 3-methyl-2- (S)-1-pyrroline- ATP-dependent sacrificial gamma- NAR_RS0105825 NAR_RS0117980 deoxyribonuclease N-methylhydantoinase: precorrin-2 C(20)- aconitate hydratase: dcm NAR_RS0114540 NAR_RS0121680 NAR_RS0114285 NAR_RS0100810 [+ 2 isozymes] oxobutanoate 5-carboxylate sulfur transferase LarE: larE glutamyltransferase: ggt acylphosphatase: histidinal 4a-hydroxytetrahydrobiopterin IV: NAR_RS0103540 NAR_RS0108825 methyltransferase: cobI NAR_RS0117810 a 5-methylcytosine NAR_RS0103760 [+ 3 isozymes] N-(γ-L-glutamyl) a single a [protein]- branched-chain ATP-dependent sacrificial gamma- an aldehyde (2R)- hydroxypyruvate N-phospho- Detoxification dehydratase: a 5'-phosphooligonucleotide N-carbamoylsarcosine precorrin-3A D-threo-isocitrate in DNA a carboxylate -L-alaninol stranded DNA histidinol amino acid sulfur transferase LarE: larE glutamyltransferase: ggt NAR_RS0101485 ethylmalonyl-CoA L-histidine dehydrogenase: hisD transaminase: an N 10 -formyl- L-glutamate-5- histidinol NAR_RS0117110 arsenate γ 7,8-dihydrofolate semialdehyde a [LarE]-dehydroalanine pyridin-1-ium-3,5- -L-glutamyl- L-cysteinylglycine dehydrogenase: hisD [+ 2 isozymes] detoxification bisthiocarboxylate mononucleotide glycylglycine II (glutaredoxin) his val arsenate a (6S)-5- α-D-mannose D-glucosamine a uridine 13 2'-deoxycytidine (3Z)-hex- a [protein]-L- cytidine arsenate FMNH 3-methylbutanoate uroporphyrinogen-III oxaloacetate GDP-β-L-fucose methylglyoxal (R)-mevalonate 2 ω glu reductase ArsC: formyltetrahydrofolate 1-phosphate 6-phosphate in tRNA cytidine deaminase: 3-en-1-ol proline ( = 180) cytidine deaminase: 5,10- uroporphyrinogen-III C- phosphomannomutase: phosphoglucosamine tRNA pseudouridine citrate (Si)-synthase: CHAT domain- peptidylprolyl GDP-L-fucose mevalonate NAR_RS0114605 NAR_RS0105710 NAR_RS0105710 glyoxalase: methenyltetrahydrofolate methyltransferase: cobA NAR_RS0101435 mutase: glmM synthase Pus10: NAR_RS0110595 containing protein: isomerase: synthase: kinase: mvk [+ 3 isozymes] 5,6-dimethylbenzimidazole acetate--CoA ligase: acs synthetase: uroporphyrinogen-III C- phosphomannomutase: phosphoglucosamine NAR_RS0106425 cytidine deaminase: citrate (Si)-synthase: NAR_RS0102780 NAR_RS0103910 cytidine deaminase: NAR_RS0104535 mevalonate arsenite NAR_RS0105990 synthase: bluB acetate--CoA ligase: acs NAR_RS0111300 methyltransferase: cobA NAR_RS0118060 mutase: glmM [+ 2 isozymes] NAR_RS0114325 NAR_RS0119775 [+ 8 isozymes] GDP-4-dehydro- NAR_RS0114325 kinase: mvk α 13 (3Z)-hex-3- 5,6-dimethylbenzimidazole [+ 3 isozymes] precorrin-2 D-mannopyranose -D-glucosamine a pseudouridine 2'-deoxyuridine citrate a [protein]-L- α-D-rhamnose uridine (R)-lactate (R)-5- synthase: bluB a 5,10- 6-phosphate 1-phosphate in tRNA en-1-yl acetate proline (ω = 0) phosphomevalonate methenyltetrahydrofolate 3-methylbutanoyl-CoA diphosphate AMP arsenite D-erythrose dialurate 5,6-dimethylbenzimidazole 4-phosphate

a dicarboxylate a dicarboxylate a dicarboxylate

sodium sodium phosphonate an amino an amino an amino an amino an amino phosphonate bicarbonate bicarbonate phosphite acid acid acid acid acid

RS0114590 RS0106150 PhnE PhnD RS0119500 RS0118720 RS0110030 RS0103010 RS0116075

sodium sodium phosphonate phosphonate an amino an amino bicarbonate bicarbonate phosphite a dicarboxylatean amino a dicarboxylatean amino a dicarboxylatean amino acid acid acid acid acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.