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Michael Krasny has interviewed a wide range of major political and cultural figures including , , Sherman Alexei, , , Margaret Atwood, , Paul Auster, Richard Avedon, , Alec Baldwin, , , , Wendell Berry, Claire Bloom, , T.S. Boyle, , Ben Bradlee, , Stephen Breyer, Tom Brokaw, David Brooks, Patrick Buchanan, William F. Buckley Jr, , , Michael Chabon, , Hillary Rodham Clinton, Cesar Chavez, , , Billy Collins, Pat Conroy, , Jacques Cousteau, Michael Crichton, Francis Crick, Mario Cuomo, , Marc Danner, Ted Danson, Don DeLillo, Gerard Depardieu, Junot Diaz, Leonardo DiCaprio, Joan Didion, . Jennifer Egan, Daniel Ellsberg, Rahm Emanuel, Nora Ephron, Susan Faludi, Diane Feinstein, , Barney Frank, , Lady Antonia Fraser, Friedman, Carlos Fuentes, John Kenneth Galbraith, Andy Garcia, Jerry Garcia, , Newt Gingrich, , , , Jane Goodall, Stephen Greenblatt, , Sammy Hagar, Woody Harrelson, Robert Hass, Werner Herzog, , , Khaled Hosseini, Patricia Ireland, Kazuo Ishiguro, Molly Ivins, , PD James, Bill T. Jones, , Ashley Judd, Pauline Kael, , , , Alonzo King, Kinnell, Ertha Kitt, , Ray Kurzweil, Jhumpa Lahiri, , , , , Michael Lewis, Maya Lin, , , YoYo Ma, , , Mickey Mantle, Wynton Marsalis, , Mary Matalin, John McCain, George McGovern, Catherine McKinnon, John McWhorter, Russell Means, Lorrie Moore, , , VS Naipaul, , , , Grover Norquist, , Edna O’Brien, Tim O’Brien, Cynthia Ozick, Orhan Pamuk, , , , Ann Patchett, Robin Wright Penn, Michael Pollan, , Francine Prose, , , Ruth Reichl, , , Joan Rivers, Richard Rodriguez, , Isabella Rossellini, Phillip Roth, , Kay Ryan, Paul Ryan, , Carl , , , , , Charles Schultz, Gary Shteyngart, , Tavis Smiley, , , Susan Sontag, Sonia Sotomayor, Eliot Spitzer, Tom Stoppard, , , , Deborah Tannen, , Twyla Tharp, , Paul Theroux, , Archbishop Desmond TuTu, , , Abraham Verghese, Derek Walcott, , , , James Watson, , Gene Wilder, Billy Dee Williams, EO Wilson, Gary Wills, Debra Winger, Naomi Wolfe, Judy Woodruff and .

Michael Krasny has conducted on-stage interviews with Isabel Allende (who also interviewed him on stage), Ann-Margaret, Nicholson Baker, Bellow, David Boies, , Ken Burns, John Cleese, Rich Cohen, , , , Richard Dawkins, EL Doctorow, Shirin Ebadi, , Stephen Jay Gould, , Brian Greene, , John Irving, , Vinod Khosla, Alan King, , Ursula LeGuin, , Robert MacNeill, Bobby McFerrin, Errol Morris, Greg Mortenson, , Joyce Carol Oates, Sandra Day O’Connor, Oz, Michael Pollan, Richard Price, , Condaleeza Rice, Cokie Roberts, Ambassador Dennis Ross, Rabbi Jonathan Sacks, George Schultz, Charles Schwab, Isaac Bashevis Singer, Jane Smiley, , , Gore Vidal, , , , Colson Whitehead, Terry Tempest Williams, Fred Wiseman and (who interviewed him on stage). In 2011 he interviewed authors Jennifer Egan and Vendela Vida at the Herbst Theater in . In 2012 at the Herbst he conducted an on-stage interview with Nobel Laureates George Smoot and Saul Pearlmutter on . In 2015 he interviewed psychiatrist Nora Volkow at the Norse Theater in San Francisco. He also interviewed film producer David Brown for ’s annual professional publishing course (2002) and James Watson and EO Wilson for Conservation International at the estate of Gordon and Betty Moore (2003) as well as John Carroll, the editor of The Times (2003) and Investigative Journalist Seymour Hirsch 2004) for the University of at Berkeley’s Graduate School of Journalism.