H5N1 avian influenza: Timeline of major events 25 January 2012

Early Events

Date Events in Animals Events in Humans 1996 Highly pathogenic H5N1 virus is isolated from a farmed goose in Guangdong Province, China. 1997 Outbreaks of highly pathogenic H5N1 are Human infections with avian influenza reported in poultry at farms and live H5N1 are reported in Hong Kong. animal markets in Hong Kong. Altogether, 18 cases (6 fatal) are reported in the first known instance of human infection with this virus. Feb 2003 Two human cases of avian influenza H5N1 infection (one fatal) are confirmed in a Hong Kong family with a recent travel history to Fujian Province, China. A third family member died of severe respiratory disease while in mainland China, but no samples were taken.

Subsequent Events

Date Events in Animals Events in Humans 25 Nov A fatal human case of avian influenza 2003 H5N1 infection occurs in China in a 24-year-old man from Beijing and is attributed to SARS. This case is retrospectively confirmed in August of 2006 (as the 20th human case in China). 12 Dec Republic of Korea first reports H5N1 in 2003 poultry. Outbreaks continue through September 2004. Dec 2003 Two tigers and two leopards, fed on fresh – Jan chicken carcasses, die unexpectedly at a zoo in 2004 Thailand. Subsequent investigation identifies a

H5N1 virus similar to that circulating in poultry. This is the first report of influenza causing disease and death in big cats. 8 Jan Viet Nam first reports H5N1 in poultry. 2004 Outbreaks continue to be reported on a regular basis.

1 This timeline is periodically updated. The last update was on: 25 January 2012

11 Jan Viet Nam identifies H5N1 as the 2004 cause of human cases of severe respiratory disease with high fatality. Sporadic human cases are reported through mid-March. 12 Jan Japan first reports H5N1 in poultry, outbreaks 2004 continue in commercial poultry through March 2004. 19 Jan Hong Kong reports H5N1 in a dead wild bird 2004 (first report in birds since poultry outbreak in 1997) 23 Jan Thailand first reports H5N1 in poultry. By the Thailand reports two laboratory- 2004 end of January, 32 provinces (throughout the confirmed cases of human infection north and several in the south) report outbreaks with H5N1. Sporadic human cases are in many types of poultry, including fighting reported through mid-March. cocks, and outbreaks continue to be reported throughout the year. The virus appears closely related to the isolates from human cases in Viet Nam. Thailand prohibits vaccination of poultry. 24 Jan Cambodia first reports H5N1 in poultry. 2004 27 Jan Lao PDR first reports H5N1 in poultry. 2004 1 Feb Investigation of a family cluster of 2004 H5N1 cases, which occurred in Viet Nam in early January, cannot rule out the possibility of limited human-to- human transmission. 2 Feb Indonesia first reports H5N1 in poultry in 11 2004 provinces. Outbreaks continue to be reported. Vaccination is allowed. 4 Feb China first reports H5N1 in poultry. During 2004 February-March, 16 mainland provinces are

affected, and approx. 9 million poultry culled. Government-subsidized vaccination initiated. 20 Feb A report from Thailand confirms that a domestic 2004 cat was infected with H5N1 after eating an infected pigeon.1 18 Mar Research2 2004 Case studies of 10 patients in Viet Nam point to close contact with infected poultry as the probable source of infection in most cases, but conclude that, in two family clusters, limited human-to-human transmission within the family cannot be ruled out. Jun/Jul China reports recurrence of H5N1 in poultry. 2004 Outbreaks continue to be reported in Indonesia, Viet Nam and Thailand. 8 Jul 2004 Research3 Research identifies the dominant Z genotype in poultry, considers possible role of wild birds in spread, and concludes that H5N1 has found a new ecological niche in poultry, but is not yet 2 This timeline is periodically updated. The last update was on: 25 January 2012

fully adapted to this host. 13 Jul Research4 2004 Research shows that H5N1 has become progressively more lethal for mammals and can kill wild waterfowl, long considered a disease- free natural reservoir. Jul 2004 Research5 A case report is published indicating atypical human H5N1 infection in Thailand (from March 2004), with fever and diarrhoea but no respiratory symptoms. The report suggests that the clinical spectrum of disease may be broader than previously thought. 12 Aug Viet Nam reports 3 new human cases, 2004 all fatal (first cases since February).

Dates of hospital admission are from 19 July to 8 August. 19 Aug Malaysia (peninsular) first reports H5N1 in 2004 poultry. Outbreaks and positive avian

surveillance samples continue to be reported through September 2004. 20 Aug Research6 2004 Chinese researchers report preliminary findings of H5N1 infection in pigs. No evidence suggests that pig infections are widespread, and the finding appears to have limited epidemiological significance. 2 Sep Research7 2004 Research shows that domestic cats experimentally infected with H5N1 develop severe disease and can spread infection to other cats. Prior to this research, domestic cats were considered resistant to disease from all influenza A viruses. 7 Sep A 4th fatal human case is reported in

2004 Viet Nam. 9 Sep Thailand confirms its third fatal case

2004 of human infection. 28 Sep Thailand confirms 2 further human

2004 cases. 4 Oct Thailand confirms its 4th human case. 2004 18 Oct Two healthy Hawk-Eagles smuggled from 2004 Thailand are seized at Brussels International Airport. HPAI H5N1 is isolated. 20 Oct A second outbreak of HPAI H5N1 in zoo tigers 2004 in Thailand occurs. It is attributed to tigers having been fed fresh chicken carcasses and

whole chickens. Altogether, 147 tigers out of a population of 441 die or are euthanized. No virus is detected in birds in zoo or local area. 25 Oct Thailand confirms its 5th human case. 3 This timeline is periodically updated. The last update was on: 25 January 2012

2004 29 Oct Research8 2004 Research confirms that domestic ducks can act as silent reservoirs, excreting large quantities of highly pathogenic virus yet showing few if any signs of illness. 3 Nov Hong Kong SAR reports H5N1 in a dead wild

2004 bird (last report January 2004). Dec 2004 Poultry outbreaks continue in Indonesia, Thailand, and Viet Nam and possibly also in Cambodia and Lao PDR. Reported outbreaks continue more or less continuously in Indonesia through August 2006, in Thailand through November 2005, and in Viet Nam though December 2005. 30 Dec Viet Nam confirms a new case. 2004 6 Jan Viet Nam confirms 2 further cases. 2005 14 Jan Hong Kong reports H5N1 in one wild bird as Total number of human cases in Viet 2005 part of routine surveillance. Nam rises to 6. Sporadic cases continue to be reported over the coming months, making Viet Nam the hardest hit country. 27 Jan Research9 2005 Research concludes that a girl in Thailand probably passed the virus to at least her mother in September 2004, causing fatal disease. This is the first published account of probable secondary human transmission, resulting in severe disease, of any avian influenza virus. 2 Feb Cambodia confirms its first human

2005 case, which is fatal. 17 Feb Research10 2005 Research retrospectively identifies at least one fatal atypical case in Viet Nam (from Feb 2004), presenting with diarrhoea and encephalitis, but normal chest X-rays. 29 Mar Cambodia confirms its 2nd human

2005 case, also fatal. 12 Apr Cambodia confirms its 3rd human

2005 case, also fatal. 30 Apr Wild birds begin dying at Qinghai Lake in 2005 central China, where hundreds of thousands of migratory birds congregate. Altogether, 6,345

birds from different species die in the coming weeks. This is the first reported instance of any HPAI causing mass die-offs in wild birds. 4 May Cambodia confirms its 4th human

2005 case, also fatal. 4 This timeline is periodically updated. The last update was on: 25 January 2012

8 Jun China reports poultry outbreak in Xinjiang 2005 Autonomous Region. Reports continue from several provinces, through February 2006. 26 Jun Japan reports LPAI H5N2 in poultry, which 2005 continues to be detected through April 2006. Source remains unconfirmed, though one rumour suggests the strain was introduced via improperly prepared vaccine. 30 Jun A WHO investigative team finds no 2005 evidence that H5N1 has increased its

transmissibility in humans in Viet Nam. 6 Jul 2005 Research11 Research on viruses isolated from dead birds in Qinghai Lake suggests the outbreak was caused by a new H5N1 variant that may be more lethal to wild birds and experimentally infected mice.

7 Jul 2005 The Philippines reports LPAI (likely an H9) in poultry. 14 Jul Research12 2005 Research on viruses isolated from dead birds in Qinghai Lake demonstrates transmission of the virus among migratory geese and suggests that the virus may be carried along winter migratory routes. 15 Jul H5N1 is detected in three captive Owston’s palm 2005 civets that died in late June in a Vietnamese wildlife preserve. This is the first reported

infection of this species with the virus. The civets were not fed chicken and the source of infection remains unknown. 21 Jul Indonesia confirms its first human 2005 case. Infection in two other family members is considered likely, but cannot be laboratory confirmed.

Subsequent investigation is unable to determine the source of infection. Virus has been circulating in poultry in Indonesia since February 2004. 23 Jul Russia reports first outbreaks of H5N1, in 2005 poultry in the Novosibirsk region. Dead migratory birds are reported in the vicinity of

outbreaks. From 23 July- 22 December 2005, a total of 62 sites in 10 regions are confirmed as HPAI H5N1-positive. 29 Jul Kazakhstan reports first H5N1 in poultry in 2005 areas adjacent to Siberia. Dead migratory birds are reported in the vicinity of outbreaks. 2 Aug Indonesia reports H5N1 in poultry and pigs 2005 during surveillance in the region where the

recent human cases lived (Tangerang district, Banten province, West Java). 10 Aug China reports additional outbreaks in several 2005 provinces through February 2006. Vaccination is initiated in affected regions using an H5N2 5 This timeline is periodically updated. The last update was on: 25 January 2012

monovalent inactivated vaccine. Mongolia reports deaths in 89 migratory birds at two lakes in Northern Mongolia. H5N1 is subsequently identified in 4 of the birds. 16 Sep Indonesia confirms its 2nd case. 2005 22 Sep Indonesia confirms its 3rd case. 2005 29 Sep Indonesia confirms its 4th case. 2005 Research13 Research describes the clinical features of H5N1 infection and reviews recommendations for the management of cases. Oct 2005 Research14 Research on the evolution of human and animal viruses circulating in Asia in 2005 suggests that several amino acids located near the receptor- binding site are undergoing change, some of which may affect antigenicity or transmissibility. 6 Oct Highly pathogenic H5N1 is first reported in Research15, 16 2005 poultry in Turkey. Research describes reconstruction of the lethal 1918 pandemic virus, concludes that this virus was entirely avian, and finds some similarities with H5N1. 7 Oct Highly pathogenic H5N1 is first reported in 2005 poultry in Romania. Reports continue through July 2006. 10 Oct Indonesia confirms its 5th human

2005 case. 20 Oct Taiwan, China reports the detection of highly Thailand confirms its 18th human 2005 pathogenic H5N1 in a cargo of exotic songbirds case (the first human case in Thailand smuggled from mainland China. since October 2004. 21 Oct Croatia first reports H5N1 in wild birds 2005 (migratory swans). H5N1 continues to be

reported in wild birds on routine surveillance, through April 2006. 23 Oct The United Kingdom reports highly pathogenic 2005 H5N1 in an imported parrot, held in quarantine, that died 3 days earlier. 24 Oct Thailand confirms its 19th human 2005 case, and Indonesia confirms its 6th and 7th human cases. 9 Nov Viet Nam confirms its 65th human 2005 case (its first human case since July 2005). 11 Nov Kuwait detects highly pathogenic H5N1 in a 2005 single migratory flamingo, marking the first report of this disease in the Gulf region.

6 This timeline is periodically updated. The last update was on: 25 January 2012

17 Nov China confirms its first two human 2005 cases, from Hunan and Anhui

provinces (does not include the case in 2003, confirmed retrospectively). 24 Nov China confirms its third human case, 2005 from Anhui province. Sporadic cases

continue to be reported in the coming weeks. 2 Dec Ukraine reports its first H5N1 outbreak in 2005 domestic birds in Crimea. Outbreaks continue to be reported through February 2006. 26 Dec Turkey reports a new outbreak in poultry in the 2005 eastern province of Igdir. Through April 2006, additional outbreaks are reported in primarily backyard poultry in 11 of the country’s 81 provinces. Wild birds are also reported to be infected. Control measures include culling of poultry in Iraqi Kurdistan and all backyard poultry in Iran within 10 km of the Turkish border. Vaccination is prohibited. Jan 2006 By the end of 2005, Indonesia has Qinghai Lake-like H5N1 viruses are reportedly confirmed a total of 20 cases in isolated from cats in Northern Iraq.17 humans. 5 Jan Turkey confirms its first two human 2006 cases. Sporadic cases continue to be reported in the coming weeks, but rapidly end. Viruses are similar to those currently circulating in birds. 20 Jan Hong Kong reports H5N1 in a dead wild bird 2006 (first report since January 2005), and H5N1 reports in wild birds (and in 2 chickens) continue through March 2006. These viruses all belong to H5N1 genotype V, which has previously been recorded in southern China, Japan and South Korea. 30 Jan Iraq confirms its first human case, in 2006 a 15-year-old girl in Sulaimaniyah (onset date 9 January 2006). 1 Feb Iraq reports its first outbreak of H5N1, in 2006 backyard flocks in same village where human case detected. 3 Feb Bulgaria first reports H5N1 in wild birds

2006 (swans). 8 Feb Nigeria first reports H5N1 in poultry. This is the 2006 first report of the virus in Africa. Outbreaks in

poultry and ornamental birds are reported through March 2006. 9 Feb Greece first reports H5N1 in wild birds (swans). 2006 Additional reports in wild birds through March 2006. 11 Feb Italy first reports H5N1 in wild birds. 2006

12 Feb Slovenia first reports H5N1 in a wild bird (swan). A total of 48 dead wild birds are 7 This timeline is periodically updated. The last update was on: 25 January 2012

2006 reported through March 2006. 13 Feb Iran first reports H5N1 in wild birds (swans) China confirms its 12th case and 8th 2006 found dead on routine surveillance. fatality. Some human cases have Russia reports H5N1 outbreaks (at large occurred in areas with no reported commercial farms) in the Caucasus region, near outbreaks in poultry. the border with Azerbaijan. Further outbreaks Indonesia confirms its 25th case and are reported in backyard poultry, pigeons, and 18th fatality. wild birds in Tyva Republic, Altaj, Tomsk, Omsk and Novosibirsk regions through July 2006. (first outbreak reported since October 2005) 14 Feb Germany first reports H5N1 in wild birds 2006 (swans). Reports of H5N1 in wild birds on

routine surveillance continue through April 2006. 17 Feb Egypt reports its first H5N1 in domestic poultry Iraq confirms its second human case. 2006 (since 1965). Outbreaks continue to be reported through December 2006. France first reports H5N1 in a wild duck (followed by additional reports in other wild birds). 18 Feb India first reports H5N1 in domestic poultry. 2006 Reported outbreaks continue through April 2006. Austria first reports H5N1 in wild birds (swans). Austria continues to find H5N1 in some wild birds on routine surveillance, until April 2006. 19 Feb Malaysia reports H5N1 in a flock of free-range 2006 poultry (last reported September 2004). Outbreaks reported through March 2006. 20 Feb Bosnia-Herzegovina and Slovakia each first

2006 report H5N1 in wild birds (migratory swans). 21 Feb Hungary first reports H5N1 in wild birds 2006 (swans). Research18 Studies of H5N1 viruses show that multiple genetically and antigenically distinct sublineages of the virus are now established in poultry in parts of Asia. Poultry-to-poultry transmission is thought to sustain endemicity of the virus in this region. H5N1 virus is isolated from apparently healthy migratory birds in southern China, suggesting that migratory birds can carry the virus over long distances. 23 Mar West Bank/Gaza Strip first reports H5N1 in

2006 poultry. Outbreaks reported through April 2006. 24 Feb Azerbaijan first reports H5N1 in migratory 2006 birds. H5N1 is later also confirmed in poultry. Georgia first reports H5N1in wild birds (swans). 25 Feb France first reports H5N1 in a single turkey 2006 farm, marking the first appearance of this disease

in domestic poultry in the EU. Had previously been identified in wild birds in France. 27 Feb Niger first reports H5N1 in domestic poultry 8 This timeline is periodically updated. The last update was on: 25 January 2012

2006 (area near border with affected states of northern Nigeria) Pakistan first reports H5N1 in poultry. Outbreaks are reported through July 2006. 28 Feb Germany reports H5N1 infection in a dead 2006 domestic cat on the Isle of Ruegen. Two more cats on the Island are found to be infected in March. Cats are thought to have been exposed by eating infected birds. 1 Mar Serbia-Montenegro first reports H5N1 in wild 2006 birds (swans). Switzerland first reports H5N1 in a dead wild bird. Additional wild birds are reported positive in March and April from various locations throughout the country on routine surveillance. 6 Mar Poland first reports H5N1 in wild birds (swans).

2006 Reports continue through May 2006. 7 Mar Albania first reports H5N1 in poultry 2006 (chickens).

Austria reports H5N1 in 3 domestic cats in an animal shelter. 9 Mar Germany reports H5N1 infection in a stone 2006 marten on the Isle of Ruegen, marking the first documented infection of this species with an avian influenza virus. Myanmar reports H5N1 in poultry (first since 1996). 11 Mar Cameroon first reports H5N1 in domestic

2006 ducks. 13 Mar Serbia-Montenegro first reports H5N1 in Iraq has its third human case, in a 3- 2006 poultry (1 rooster). Had been previously reported year- -old boy (case retrospectively in wild birds. confirmed in September, 2006) 14 Mar Denmark first reports H5N1 in a wild bird. Azerbaijan confirms its first human 2006 Reports in wild birds continue through May of cases (onset dates from mid-February 2006. 2006). 15 Mar Afghanistan first reports H5N1 in poultry and a

2006 crow. 16 Mar Israel first reports H5N1 in poultry. 2006 Sweden first reports H5N1 in 36 dead wild birds tested in February and March (no increase in overall wild bird mortality) 17 Mar Khazakstan reports H5N1 in wild birds (first 2006 since August 2005) Sweden first reports HPAI H5 (no N type given) in poultry in a game bird holding within the surveillance zone set up in response to detection of H5N1 in wild birds. 20 Mar Egypt confirms its first human case 2006 in a 30-year-old woman from Qalubiya (onset early March 2006). 23 Mar Cambodia reports its first outbreak in poultry Research19, 20 2006 since December 2004. Outbreaks continue to be Two research groups publish findings 9 This timeline is periodically updated. The last update was on: 25 January 2012

reported through fall 2006. that may help explain why the H5N1 Jordan first reports H5N1 in poultry. virus does not easily infect humans or – like normal seasonal influenza – spread readily by coughing or sneezing. Whereas human influenza viruses attach themselves to molecules in cells lining the nose and throat, avian viruses prefer to bind to molecules located deep in the lungs. Such findings are consistent with the clinical picture of H5N1 infection, in which most patients present with symptoms of infection in the lower respiratory tract, with rapid progression to pneumonia. 27 Mar Czech Republic first reports H5N1 in a wild 2006 bird (swan). Reports in wild swans continue through May 2006.

Sweden detects H5N1 in a wild mink in southern Sweden in an area where wild birds cases have been detected. 3 Apr Burkina Faso first reports H5N1 in poultry

2006 (guineafowl). 5 Apr Germany first reports H5N1 in poultry, in 2006 turkeys on a single farm (previously reported in wild birds). 6 Apr Cambodia confirms its 6th human 2006 case in a 12-year-old boy from Prey United Kingdom first reports H5N1 in a single Vang (onset date 29 March 2006) wild bird (swan). (first human case in Cambodia since April 2005). 12 Apr Indonesia confirms its 31st human 2006 case in a 23-year-old man from West Java (onset date 20 March 2006). 13 Apr Egypt confirms its 12th human case in 2006 a 18-year-old woman from Minufiyah (onset date 5 April 2006). 17 Apr Sudan first reports H5N1 in poultry (both 2006 intensive and backyard systems). Additional outbreaks reported through October 2006. 19 Apr China confirms its 17th human case in China reports H5N1 in wild aquatic and other 2006 an 21-year-old man from Hubei birds in Qinghai and Tibet regions. (onset date 1 April 2006). Côte d’Ivoire first reports H5N1 in poultry and Indonesia confirms its 32nd human a wild bird. Outbreaks continue to be reported case in a 24-year-old man from through July 2006. Banten (onset date 29 March 2006). 24 Apr Djibouti reports its first case of H5N1 in

2006 poultry. 27 Apr China confirms its 18th human case in 2006 an 8-year-old girl from Sichuan (onset date 16 April 2006). 4 May Mongolia reports H5N1 in dead wild birds on Egypt confirms its 13th human case in 2006 routine surveillance through June 2006 (last a 27-year-old woman from Cairo report August 2005). (onset date 15 April 2006).

10 This timeline is periodically updated. The last update was on: 25 January 2012

8 May Indonesia confirms its 33rd human 2006 case in a 30-year-old man from Jakarta (onset date 17 April 2006) 9 May Ukraine first reports HPAI H5 in wild birds

2006 (previously reported in poultry) 12 May Djibouti confirms its first human case 2006 in a 2-year-old girl from Arta (onset date 23 April 2006). 18 May Denmark reports its first outbreak of H5N1 Egypt confirms its 14th case in a 75- 2006 HPAI in domestic poultry (was previously year- -old woman from Al Minya reported in wild birds). An outbreak of H5N2 (onset date 11 May 2006). LPAI was also reported during this period. Indonesia reports the largest family cluster in any country to date, with 7 confirmed cases (the 34th through 39th and the 42nd) from 4 households in the Karo district of North Sumatra. The index case (unconfirmed) develops symptoms on 24 Apr, the last case dies on 22 May. Cases include the index case’s 2 sons, (aged 15 and 17 years), her 10-year-old nephew, her 2 brothers (aged 25 and 32 years), her 28-year-old sister, and this sister’s 18- month-old daughter. Disease does not spread beyond the extended family. Limited human to human transmission can not be ruled out. Viruses do not show any significant genetic mutations or reassortment. Indonesia also confirms its 40th human case, in a 38-year-old woman from East Java (onset date 2 May 2006). 19 May Indonesia confirms its 41st human 2006 case in a 12-year-old boy from East Jakarta (onset date 7 May 2006). 29 May Indonesia confirms its 43rd – 48th 2006 human cases in an 18-year-old man from East Java (onset date 6 May 2006), a 10-year-old girl and her 18- year–old brother from West Java (both with onset date 16 May 2006), a 39-year-old man from Jakarta (onset date 9 May 2006), a 43-year-old man from Jakarta (onset date 6 May 2006), and a 15-year-old girl from West Sumatra (onset date 17 May 2006). All 6 cases are unrelated to the family cluster in Karo, North Sumatra. 4 Jun China reports its first cases in poultry since 2006 February 2006. Outbreaks reported from various provinces through October 2006. 6 Jun Indonesia confirms its 49th human 2006 case in a 15-year-old boy from West Java (onset date 26 May 2006). 9 Jun Hungary reports its first H5N1 in poultry 11 This timeline is periodically updated. The last update was on: 25 January 2012

2006 (previously reported in wild birds). 15 Jun Ukraine reports H5N1 in poultry (first report Indonesia confirms its 50th human 2006 since February 2006), first reported in wild birds case in a 7-year-old girl from Banten in May 2006. (onset date 26 May 2006). China confirms its 19th human case, 16 Jun in a 31-year-old man from Guandong 2006 (onset date 3 June 2006). 20 Jun Indonesia confirms its 51st human 2006 case in a 13-year-old boy from Jakarta (onset date 9 June 2006). 30 Jun Research21 2006 The first analysis of epidemiological data on all 205 laboratory-confirmed H5N1 cases officially reported to WHO from Dec 2003 to 30 Apr 2006 is published by WHO. Indonesia confirms its 52nd human 4 Jul 2006 case in a 5-year-old boy from East Java (onset date 8 June 2006). 7 Jul 2006 Spain first reports H5N1 in a single wild shore

bird (grebe) in northern region. 14 Jul Indonesia confirms its 53rd human 2006 case in a 3-year-old girl from Jakarta (onset date 23 June 2006). 20 Jul Indonesia confirms its 54th human 2006 case in a 44-year-old man from Jakarta (onset date 24 June 2006). 26 Jul Thailand confirms its 23rd human Thailand reports two H5N1 outbreaks in poultry 2006 case in a 17-year-old boy from Phichit (in Phichit and Nakhon Phanom provinces). in northern Thailand (onset date 15 These are the first reported in more than 8 July 2006) (the first human case in months. Poultry vaccination remains prohibited. Thailand in 2006). 27 Jul Lao PDR reports H5N1 in poultry (first reported

2006 since January 2004) 3 Aug H5N1 is detected in a captive zoo swan in 2006 Germany (previously reported in both wild and domestic birds) 30 Aug Viet Nam reports H5N1 in unvaccinated duck 2006 flocks and market ducks on routine surveillance.

Ducks did not show clinical signs. (First report since December 2005) 7 Aug Thailand confirms its 24th human 2006 case in a 27-year-old man from Uthai

Thani in central Thailand (onset date 24 July 2006). 8 Aug China retrospectively confirms its 2006 20th human case in a 24-year-old man from Beijing (onset date 25 November 2003) who died. This case becomes the first confirmed case of HPAI H5N1 infection in the present outbreak. The case was initially

12 This timeline is periodically updated. The last update was on: 25 January 2012

attributed to SARS. Indonesia confirms its 55th human case in a 16-year-old boy from West Java (onset date 26 July 2006), and becomes the country with the most human deaths (n=43) from H5N1 HPAI infection, surpassing Viet Nam. A system for unified H5N1 nomenclature, developed by the WHO/OIE/FAO Evolution Working Group, is posted on the WHO website (http://www.who.int/csr/ disease/avian_influenza/guidelines/ nomenclature/en/index.html) and the OFFLU website (www.offlu.net). 9 Aug Indonesia confirms its 56th human 2006 case in an 17-year-old girl from Jakarta (onset date 28 July 2006). 14 Aug Indonesia confirms its 57th human 2006 case in an 17-year-old boy from West

Java (Cikelet/Garut Cluster) (onset date 26 July 2006). 14 Aug The USA detects LPAI H5N1 in wild mute China confirms its 21st human case in 2006 swans in Michigan. a 62-year-old man from the Uygur Autonomous Region in north-western China (onset date 19 June 2006). 17 Aug Indonesia confirms its 58th human 2006 case in an 9-year-old girl from West

Java (Cikelet/Garut Cluster) (onset date 1 August 2006). 21 Aug Indonesia confirms its 59th human 2006 case in an 35-year-old woman from West Java (Cikelet/Garut Cluster) (onset date 8 August 2006). In this cluster, there was no evidence of human to human transmission, poultry deaths were possibly linked with live chickens returning to village from live animal market, and there were possible additional human cases that were not confirmed. 23 Aug Indonesia confirms its 60th human 2006 case in an 6-year-old girl from West Java (onset date 6 August 2006). 2 Sep The USA detects LPAI H5N1 in wild ducks in 2006 Pennsylvania and Maryland.

8 Sep Indonesia confirms its 61st human 2006 case in an 14-year-old girl from South Sulawesi (onset date 18 June 2006). Due to revisions to the WHO case definition, two cases are retrospectively confirmed in Indonesia: The 62nd in an 8-year-old girl from Banten (onset date 24 June 2005) and the 63rd in a 45-year-old 13 This timeline is periodically updated. The last update was on: 25 January 2012

man from central Java (onset date 25 November 2005). 14 Sep Indonesia confirms its 64th human 2006 case in a 5-year-old boy from West Java (onset date 4 March 2006)and (through follow up testing) its 65th human case in a 27-year-old male from West Sumatra (onset date 28 May 2006) (brother of 15-year-old girl; was possible human to human transmission). 25 Sep Indonesia confirms its 66th human 2006 case in an 11-year-old boy from East Java (onset date 16 September

2006)and its 67th human case in a 9- year-old boy from Jakarta (onset date 13 September 2006). 27 Sep Indonesia confirms its 68th human 2006 case in a 20-year-old man from West Java (onset date 17 September 2006). 27 Sep Thailand confirms its 25th human 2006 case, in a 59-year-old man from Nong Bua Lam Phu Province in Northeastern Thailand (onset date 14 July 2006). 3 Oct Indonesia confirms its 69th human 2006 case in a 21-year-old woman from

East Java (onset date 19 September 2006) (the sister of the 66th case). 11 Oct Egypt confirms its 15th human case, 2006 in a 39-year-old woman from Gharbiya (onset date 30 September 2006) (the first human case since May 2006). 16 Oct Indonesia confirms its 70th human 2006 case in a 67-year-old woman from West Java (onset date 3 October 2006), its 71st human case in a 11- year-old boy from Jakarta (onset date 2 October 2006), and its 72nd human case in a 27-year-old woman from Central Java (onset date 8 October 2006). 30 Oct Research22 2006 A surveillance study of H5N1 isolates from poultry in southern China confirms that subtypes continue to emerge and their relative prevalence continues to change. 13 Nov Indonesia confirms its 73rd human 2006 case in a 35-year-old woman from Banten (onset date 7 November 2006)

and its 74th human case, in a 30 month old boy from West Java (onset date 10 November 2006). 22 Nov Republic of Korea reports H5N1 in poultry 14 This timeline is periodically updated. The last update was on: 25 January 2012

2006 (first since September 2004). Outbreaks continue to be reported. 10 Dec China confirms its 22nd human case 2006 in a 37-year-old man from Anhui (onset date 10 December 2006) (retrospectively confirmed on 10 January 2007). 14 Dec In an effort to contain the disease, live animal 2006 markets in Beijing, China are permanently closed. 19 Dec Viet Nam reports H5N1 in unvaccinated poultry 2006 (first report since August 2006). Outbreaks

become widespread in the southern part of the country. 27 Dec Egypt confirms its 16th, 17th, and 18th 2006 human cases in an extended family in Gharbiyah (onset dates 9-15 December 2006). The isolated viruses had a genetic mutation, linked in laboratory testing to moderately reduced susceptibility to oseltamivir. WHO does not change treatment recommendations. 8 Jan Indonesia confirms its 75th human 2007 case, in a 14-year-old boy from West

Jakarta (onset date 31 December 2006). 9 Jan Indonesia confirms its 76th human 2007 case, in a 37-year-old woman from Banten (onset date 1 January 2007). 12 Jan Indonesia confirms its 77th human 2007 case, in a 22-year-old woman from Banten (onset date 3 January 2007). 13 Jan Japan reports H5N1 in poultry (first since

2007 March 2004). 15 Jan Indonesia confirms its 78th human 2007 case, in a 27-year-old woman from South Jakarta (onset date 6 January Hong Kong reports H5N1 in dead wild birds 2007) and its 79th human case, in a (first since January 2006). 18-year-old boy from Banten (onset date 10 January 2007) (son of the 76th case). 16 Jan Thailand reports H5N1 in poultry during routine 2007 intensive surveillance (first since July 2006). Vaccination remains prohibited. 17 Jan Viet Nam reports continued H5N1infection in

2007 farmed and village poultry th 22 Jan Egypt confirms its 19 human case, 2007 in a 27-year-old woman from Beni Sweif (onset date 9 January 2007). 22 Jan Indonesia confirms its 80th human 2007 case, in a 32-year-old woman from

West Java (onset date 8 January 2007).

15 This timeline is periodically updated. The last update was on: 25 January 2012

24 Jan Hungary reports H5N1 in poultry (first since

2007 June 2006). st 25 Jan Indonesia confirms its 81 human 2007 case, in a 6-year-old girl from Central Java (onset date 8 January 2007). 26 Jan Russia reports H5N1 in poultry (first report

2007 since July 2006). 27 Jan The United Kingdom reports H5N1 on a 2007 commercial turkey farm (first ever report in

poultry, reported in wild birds in April 2006). Only a single outbreak occurs. 28 Jan In an effort to curb virus spread, Indonesia 2007 institutes a poultry ban for the entire island of Java, and bans backyard poultry in 9 provinces. 31 Jan Nigeria confirms its first human case, 2007 in a 22-year-old woman from Lagos (onset date 8 January 2007). 1 Feb Pakistan reports H5N1 in poultry (first since

2007 July 2006). th 6 Feb Egypt confirms its 20 human case, 2007 in a 17-year-old girl from Fayoum (onset date 25 January 2007). 23 9 Feb Research 2007 The second WHO analysis of epidemiological data on WHO- confirmed human cases of avian influenza A (H5N1) infection, 25 November 2003 – 24 November 2006 is published by WHO. 9 Feb Turkey reports H5N1 in backyard poultry (first

2007 report since April 2006). st 15 Feb Egypt confirms its 21 human case, 2007 in a 37-year-old woman from Fayoum (onset date 10 February 2007). nd 19 Feb Egypt confirms its 22 human case, 2007 in a 5-year-old boy from Sharkia (onset date 14 February 2007). 20 Feb Ongoing H5N1 outbreaks in poultry in several

2007 states of Nigeria are reported by FAO. 24 19 Feb Lao PDR reports H5N1 in poultry (first reported

2007 since July 2006). 22 Feb Afghanistan reports H5N1 in backyard poultry

2007 and farms (first report since March 2006). Lao PDR confirms its first human 26 Feb Kuwait reports H5N1 in poultry in backyards, case, in a 15-year-old girl from 2007 on farms, and in a zoo (first report in birds since Vientiane (onset date 10 February November 2005. First ever report in poultry). 2007). rd 28 Feb Myanmar reports H5N1 in poultry (first report Egypt confirms its 23 human case, 2007 since April 2006). in a 4-year-old girl from Dakahlea (onset date 25 February 2007). China confirms its 23rd human case, in a 44-year-old woman from Fujian (onset date 18 February 2007). 6 Mar China reports H5N1 in poultry (first report since

2007 September 2006).

16 This timeline is periodically updated. The last update was on: 25 January 2012

th 12 Mar Egypt confirms its 24 human case, 2007 in a 4-year-old boy from Dakahlea (onset date 7 March 2007). 16 Mar Lao PDR confirms its second human case, in a 42-year-old woman from 2007 Vientiane Province (onset date 26 February 2007). th 19 Mar Egypt confirms its 25 human case, 2007 in a 10-year-old girl from Aswan (onset date 13 March 2007). th 20 Mar Egypt confirms its 26 human case, 2007 in a 2-year-old boy from Aswan (onset date 15 March 2007).

China confirms avian influenza H9N2 infection in a 9-month-old girl with mild signs of disease. th 26 Mar Egypt confirms its 27 human case, 2007 in a 3-year-old girl from Aswan (onset date 22 March 2007). No epidemiological link is evident among the three recent cases from Aswan. 27 Mar During high level talks in Jakarta, Indonesia announces that it will 2007 resume sharing H5N1 AI virus with the international community. th 28 Mar Egypt confirms its 28 human case, 2007 in a 6-year-old girl from Qena, and its 29th human case, in a 5-year-old boy from Menia. (both had onset date 26 March 2007) th 29 Mar China confirms its 24 human case, 2007 in a 16-year-old boy from Anhui (onset date 17 March 2007). 30 Mar Bangladesh reports H5N1 in poultry (first ever

2007 in Bangladesh). th 2 Apr Egypt confirms its 30 human case, 2007 in a 4-year-old boy from Qena (brother of the 28th case), its 31st human case, in a 7-year-old boy from Sohag (both with onset date 26 March Saudi Arabia reports H5N1 in poultry (first 2007), and its 32nd human case, in a 4- ever in Saudi Arabia) year-old girl from Qalyoubia (onset date 29 March 2007).

According to the Ministry of Health in Indonesia, cases of H5N1 infection in humans continue to occur. th 10 Apr Cambodia confirms its 7 human 2007 case, in a 13-year-old girl from Kampong Cham (onset date 2 April 2007) (first human case since March 2006).

Egypt confirms its 33rd human case, in a 2-year-old girl from Menia (onset date 3 April 2007) and its 34th human case in a 15-year-old girl from Cairo (onset date 30 March 2007). 12 Apr Cambodia reports H5N1 in village poultry (first

2007 report in poultry since August 2006).

17 This timeline is periodically updated. The last update was on: 25 January 2012

3 May Ghana reports H5N1 in poultry (first ever in

2007 Ghana). 16 May WHO retrospectively confirms 15 2007 human cases and 13 deaths in Indonesia, bringing the total confirmed human cases to 96, with 76

deaths. Cases had onset dates between 25 January and 3 May 2007, and had been initially confirmed by the Indonesian Ministry of Health. 23 May A resolution on international sharing of influenza viruses is reached at the 2007 WHO World Health Assembly in Geneva. 24 May Viet Nam reports multiple outbreaks in 2007 unvaccinated poultry (primarily ducks) from several provinces throughout the country. Indonesia confirms its 97th human case, in a 5-year-old girl from Central Bangladesh reports multiple outbreaks in Java (onset date 8 May 2007). poultry from additional provinces throughout the country. 25 May The United Kingdom Health 2007 Protection Agency reports at least 4 human infections with low pathogenic

avian influenza H7N2. The cases are associated with reported H7N2 infections in poultry. th 30 May China confirms its 25 human case, in a 19-year-old soldier stationed in 2007 Fujian province (onset date 9 May 2007). th 31 May Indonesia confirms its 98 human case, in a 45-year-old man from 2007 Central Java (onset date 17 May 2007). 2 Jun Malaysia reports its first outbreak in poultry

2007 since March, 2006 (in village chickens). th 6 Jun Indonesia confirms its 99 human case, in a 16- year-old girl from 2007 Central Java (onset date 21 May 2007). th 11 June Egypt confirms its 35 human case, 2007 in a 10-year-old girl from Qena (onset date 1 June 2007). th 12 Jun Egypt confirms its 36 human case, 2007 in a 4-year-old girl from Qena (onset date 7 June 2007) (no epidemiological link between these two most recent Egyptian cases). th 15 Jun Indonesia confirms its 100 human 2007 case, in a 27- year-old man from Riau (onset date 3 June 2007). 22 Jun Czech Republic reports its first outbreak ever in 2007 poultry (in commercial turkeys).

Togo reports its first outbreak ever in poultry (in commercial chickens). th 25 June Egypt confirms its 37 human case, 2007 in a 4-year-old boy from Qena (onset date 20 June 2007). 18 This timeline is periodically updated. The last update was on: 25 January 2012

Indonesia confirms its 101st human case, in a 3- year-old girl from Riau (onset date 18 June 2007). 26 Jun Germany reports H5N1 in wild birds found 2007 dead (first reports since detected in commercial poultry in April 2006). 29 Jun Viet Nam confirms it first human 2007 cases since November, 2005, in a 29- year-old man from Vinh Phuc (onset Czech Republic reports H5N1 in a dead mute date 10 May 2007) and a 19-year-old swan (first in wild birds since May 2006). man from Thai Nguyen (onset date 20 May 2007). No epidemiological link between these two cases has been identified. There have been 95 human cases in Viet Nam since 2003. 5 Jul 2007 France reports H5N1 in wild swans found dead (first report since detected in commercial turkeys in February 2006). Germany reports H5N1 in a dead domestic 6 Jul 2007 goose nd 11 Jul Indonesia confirms its 102 human 2007 case, in a 6-year-old girl from Banten (onset date 23 June 2007). 15 Jul Bangladesh Ministry of Agriculture reports 2007 continued H5N1 outbreaks in commercial and backyard poultry. th 25 Jul Egypt confirms its 38 human case, 2007 in a 25-year-old woman from Damietta (onset date 20 July 2007). 26 Jul India reports H5N1 in backyard poultry (first

2007 report since April 2006). July 2007 In a letter published in Emerging Infectious Diseases, a HPAI H5N1 virus was detected by PCR in a common teal in Damietta governorate in the Nile Delta region, Egypt, in December 2005. The sample was collected through routine sampling of wild migratory birds prior to the detection of the first outbreaks in poultry (in February 2006) (http://www.cdc.gov/eid/content/13/7/1120.htm). rd 14 Aug Indonesia confirms its 103 human 2007 case, in a 29-year-old woman from Bali (onset date 3 August 2007). 25 15 Aug Research 2007 A study describing the epidemiology of 54 human cases of H5N1 infection in Indonesia is published.

Conclusions included that 76% of cases were associated with poultry contact, and the source of infection was not identified in 24% of cases. th 16 Aug Indonesia confirms its 104 human 2007 case, in a 17-year-old woman from Banten (onset date 9 August 2007). th 23 Aug Indonesia confirms its 105 human 2007 case, in a 28-year-old woman from Bali (onset date 14 August 2007). 30 Aug The WHO criteria for accepting

2007 confirmed cases of A(H5) infection 19 This timeline is periodically updated. The last update was on: 25 January 2012

are amended. 31 Aug Based on amended acceptance 2007 criteria, Viet Nam retrospectively confirms its 96th through 100th cases, in a 28-year-old woman from Ha Nam (onset date 3 June 2007), a 29-year- old man (onset date 30 May 2007)

and a 15-year-old boy (onset date 27 July 2007) from Thanh Hoa, and a 20-year-old man (onset date 2 June 2007) and a 22-year-old woman (onset date 20 July 2007) from Ha Tay. 07 Sept Russia reports H5N1 in poultry (first report

2007 since January 2007). th 10 Sept Indonesia confirms its 106 human 2007 case, in a 33-year-old man from Riau (onset date 25 August 2007). 15 Sept China reports H5N1 in commercial ducks in

2007 Guandong (first report since May 2007). th 2 Oct Indonesia confirms its 107 human case, in a 21-year-old man from 2007 Jakarta (onset date 18 September 2007). th 8 Oct Indonesia confirms its 108 human 2007 case, in a 44-year-old woman from Riau (onset date 1 October 2007). 11 Oct Viet Nam reports H5N1 in unvaccinated ducks

2007 in Tra Vinh (first report since August 2007). th 12 Oct Indonesia confirms its 109 human case, in a 12-year-old boy from 2007 Banten (onset date 30 September 2007). 26 15 Oct According to FAO , H5N1 has caused recent 2007 outbreaks in poultry in 19 districts in Bangladesh and 4 districts in Indonesia, and in commercial poultry in Ogun, Nigeria (in September). 24 Oct Myanmar reports H5N1 in commercial poultry

2007 in Bago (first report since August 2007). th 25 Oct Indonesia confirms its 110 human 2007 case, in a 5-year-old girl from Banten (onset date 14 October 2007). th 31 Oct Indonesia confirms its 111 human 2007 case, in a 3-year-old boy from Banten. Viet Nam reports H5N1 in unvaccinated poultry Both this case and the 110th case in 3 additional provinces. became ill on 14 October, but no epidemiological link between them has been identified. th 5 Nov Indonesia confirms its 112 human 2007 case, in a 30-year-old woman from Banten (onset date 23 October 2007). th 12 Nov Indonesia confirms its 113 human 2007 case, in a 31-year-old man from Riau (onset date 31 October 2007). 13 Nov UK reports H5N1 in a flock of free-range

2007 turkeys in England (first since January 2007).

20 This timeline is periodically updated. The last update was on: 25 January 2012

19 Nov Saudi Arabia reports H5N1 in commercial

2007 chickens in four areas of Ar Riyad. 22 Nov Pakistan reports H5N1 in commercial, poultry 2007 in the North West Frontier (first outbreak in poultry since July 2007). 23 Nov Myanmar reports H5N1 in backyard poultry in

2007 a new province (Shan state) 27 Nov Romania reports H5N1in backyard poultry in 2007 Tulcea (first outbreak in poultry since May 2006). 3 Dec Poland reports H5N1 in young turkeys in 2007 Mazowieckie (first outbreak ever in poultry, last H5N1 reported in a wild swan in May 2006).

Egypt retrospectively reports 579 outbreaks of H5N1 in birds from 23 March 2006 through 24 November 2007. th 4 Dec China confirms its 26 human case, 2007 in a 24-year-old man from Jiangsu (onset date 24 November 2007). 5 Dec Benin reports highly pathogenic avian influenza (not confirmed as H5N1) in poultry in Cotonou 2007 and Adjara (first HPAI outbreak ever reported in Benin). Later reported as H5N1by FAO.27 th 9 Dec China confirms its 27 human case, in a 52-year-old man from Jiangsu 2007 (onset date 3 December 2007), who is the father of the 26th case. 12 Dec Russia reports H5N1 in poultry in Rostovskaya 2007 (first outbreak in poultry since September 2007). Pakistan reports additional H5N1 outbreaks in Indonesia confirms its 114th human commercial poultry in North West Frontier and case, in a 28-year-old woman from Punjab provinces. Banten (onset date 1 December 2007). Poland reports H5N1 in birds in a second province (Warminsko-Mazurskie).

th 13 Dec Indonesia confirms its 115 human 2007 case, in a 47-year-old man from Banten (onset date 2 December 2007). 14 Dec Myanmar confirms its first human 2007 case, in a 7-year-old girl from Shan State (onset date 21 November 2007). 15 Dec Pakistan informs WHO of 8 people 2007 in the North West Frontier Province that have tested positive for H5N1 in the national reference laboratory. These are the first suspected human

cases ever reported in Pakistan. The presence of virus was confirmed in samples from one of these patients, a 25-year-old man from Peshawar (onset date 21 November). 27 17 Dec According to FAO , H5N1has continued to 2007 cause outbreaks in poultry in areas of Indonesia (Bali, Java, Sulawesi, Sumatra) and Viet Nam (Tra Vinh, Cao Bang, Quang Tri) in November and December. th 26 Dec Indonesia confirms its 116 human case, in a 24-year-old woman from 2007 Jakarta (onset date 14 December 2007). 21 This timeline is periodically updated. The last update was on: 25 January 2012

Egypt confirms its 39th human case, in a 25-year-old woman from Beni Sweif (onset date 23 December 2007). This is the first case confirmed by Egypt since July 2007. st 28 Dec Viet Nam confirms its 101 human 2007 case in a 4-year-old boy from Son La (onset date 7 December 2007). The last case confirmed by Viet Nam had an onset of July 2007. Egypt confirms its 40th human case in a 50-year-old woman from Domiatt (onset date 24 December 2007) and its 41st human case in a 22-year-old woman from Menofia (onset date 26 December 2007). 29 Dec Myanmar reports ongoing outbreaks of H5N1

2007 in backyard poultry in Shan state. 31 Dec Benin reports H5N1 in poultry in two new

2007 provinces (Dangbo and Porto Novo) 3 Jan Israel reports H5N1 in birds in a petting zoo in

2008 Haifa (first outbreak since March 2006) nd 2 Jan Egypt confirms its 42 human case 2008 in a 25-year-old woman from Dakahlia (onset date 26 December)

and its 43rd human case in a 36-year- old woman from Menofia (onset date 26 December 2007). 4 Jan China reports H5N1 in poultry in Xinjiang (first 2008 outbreak reported in this province since September 2006) 7 Jan Viet Nam reports H5N1 in poultry in 4 2008 provinces (Tra Vinh, Cao Bang, Thai Nguyen, and Quang Tri). th 11 Jan Indonesia confirms its 117 human 2008 case, in a 16-year-old girl from West Java (onset date 30 December 2008) 15 Jan India reports H5N1 in backyard and commercial 2008 poultry in West Bengal State (first since July 2007). Indonesia confirms its 118th human

case, in a 32-year-old woman from Egypt reports widespread H5N1 outbreaks in Banten (onset date 3 January 2008) backyard and commercial poultry (including in vaccinated poultry) in 17 governorates during December and early January. 16 Jan Iran reports H5N1 in backyard poultry in

2008 Mazandaran (first since February 2006). Indonesia confirms its 119th human 21 Jan Ukraine reports H5N1 in poultry in Crimea case, in an 8-year-old boy from 2008 (first since June 06). Banten (onset date 7 January 2008). 22 Jan Germany reports ongoing outbreaks of H5N1 in 2008 backyard birds in Brandenburg.

Turkey reports H5N1 in backyard poultry in Zonguldak (first report since February 2007). th 23 Jan Thailand reports H5 in poultry in Nakhon Indonesia confirms its 120 human 2008 Sawan and Phichit (first reports since March case, in a 30-year-old man from 2007). Banten (onset date 13 January 2008).

22 This timeline is periodically updated. The last update was on: 25 January 2012

nd 24 Jan Viet Nam confirms its 102 human 2008 case in a 34-year-old man from Tuyen Quang (onset date 10 January 2008). st 29 Jan Indonesia confirms its 121 human 2008 case in a 31-year-old woman from Jakarta (onset date 18 January 2008), its 122nd human case in a 9-year-old China reports H5N1 in poultry in the Tibet boy from West Java (onset date 16 Autonomous Region (first report in this province January 2008), 123rd human case in a since March 2007). 32-year-old man from Banten (onset date 17 January 2008), and its 124th human case in a 23-year-old woman from Jakarta (onset date 19 January 2008). 2 Feb Pakistan reports outbreaks of H5N1 on 2008 commercial farms in Sindh (Karachi)(first reports since November 2007). th 5 Feb Indonesia confirms its 125 human case in a 29-year-old woman from 2008 China retrospectively reports H5N1 in two wild Banten (onset date 22 January 2008), birds in Tuen Mun Park, Hong Kong SAR and its 126th human case in a 38-year- (detected in November and December 2007). old woman from Jakarta (onset date 24 January 2008). 6 Feb United Kingdom continues to report sporadic deaths due to H5N1 in mute swans in southern 2008 England (detected in November and December 2007). 11 Feb According to FAO28, Indonesia continues to

2008 experience outbreaks of H5N1 in poultry. th 12 Feb Indonesia confirms its 127 human 2008 case in a 15-year-old girl from Jakarta (onset date 2 February 2008) 13 Feb Laos reports H5N1 in poultry in Luang Namtha

2008 (first report since February, 2007) rd 15 Feb Viet Nam confirms its 103 human 2008 case, in a 40-year-old man from Hai Duong (onset date 2 February 2008). 17 Feb Saudi Arabia reports H5N1 in poultry in Ar 2008 Riyad, outbreaks dated from Oct 07 through Jan 08. 18 Feb Nigeria reports H5N1 in poultry in Anambra

2008 (first report since March 2006). China confirms its 28th human case, 20 Feb Pakistan reports new H5N1 outbreaks in poultry in a 22-year-old man from Hunan 2008 in North West Frontier province. (onset date 16 January 2008). th 21 Feb Indonesia confirms its 128 human 2008 case in a 16-year-old man from Central Java (onset date 3 February 2008), and its 129th human case in a 3-year-old boy from Jakarta (onset date 3 February 2008). Viet Nam confirms its 104th human case in a 27-year-old man from Ninh Binh (onset date 3 February 2008) th 22 Feb China confirms its 29 human case, in a 41-year-old man from Guanxi 2008 Autonomous Region (onset date 12 February 2008). 25 Feb Viet Nam continues to report outbreaks of 23 This timeline is periodically updated. The last update was on: 25 January 2012

2008 H5N1 in poultry from several provinces. China reports H5N1 in poultry in a new province, Guizhou (first report from this province since January 2006). China confirms its 30th human case, 26 Feb Turkey reports H5N1 in poultry in a new in a 44-year-old woman from 2008 province, Sinop. Guangdong (onset date 16 February).

Viet Nam confirms its 105th human Pakistan reports new H5N1 outbreaks in poultry case, in a 23-year-old-woman from in Sindh province. Phu Tho (onset date 14 February). th 28 Feb Egypt confirms its 44 human case in 2008 a 4-year-old girl from Minea (onset date 21 February). 1 Mar Myanmar reports AI-seropositive ducks 2008 detected during surveillance in Shan State (serotype not reported). th 4 Mar Egypt confirms its 45 human case in 2008 a 26-year-old woman from Fayoum (onset date 24 February). th 5 Mar Egypt confirms its 46 human case in 2008 a 11-year-old boy from Minea (Hospitalization date 26 February). 9 Mar According to the Ministry of Fisheries and 2008 Livestock in Bangladesh, 47 districts have now had confirmed outbreaks of H5 infection in birds.

According to the Department of Animal Husbandry, Dairying, and Fisheries in India, additional H5 infection in birds has been confirmed in West Bengal. 10 Mar Pakistan reports new H5N1 outbreaks in poultry

2008 in North West Frontier Province. th 11 Mar Egypt confirms its 47 human case in 2008 a 8-year-old boy from Fayoum (Hospitalization date 3 March 2008). 16 Mar China reports H5N1 in poultry at a live animal market in Guangdong 2008 Viet Nam confirms its 106th human

case, in an 11-year-old boy from Ha According to FAO, HPAI is still being detected Nam (onset date 4 March). in poultry on three islands of Indonesia, Bali, Java, and Sumatra. 29 18 Mar Turkey reports H5N1 in backyard poultry in

2008 Edirne 30 25 Mar Research 2008 A study is published describing the epidemiological association between the

presence of H5N1 virus and duck populations, human populations, and rice production in Viet Nam and Thailand. 28 Mar India reports additional outbreaks in backyard

2008 poultry in West Bengal 31 Mar Switzerland reports H5N1 in a healthy wild bird 2008 in Luzern Canton (first report in country since June 2006). 1 Apr Viet Nam continues to report outbreaks of

2008 H5N1 in poultry from several provinces. 2 Apr Republic of Korea reports H5N1 in poultry in Indonesia confirms its 130th human 2008 Cholla-Bukdo (first report in country since June case, in a 15-year-old boy from West 24 This timeline is periodically updated. The last update was on: 25 January 2012

2007) Java (onset date 19 March 2008), its 131st human case in a 11-year-old girl from West Java (onset date 19 March 2008) and its 132nd human case in a 21-month old girl from West Sumatra (onset date 17 March 2008). There has been no epidemiological link identified among the cases. 3 Apr Pakistan confirms two additional 2008 cases in a family cluster in North West Frontier Province in Oct-Nov 2007, suggesting limited human to human transmission likely occurred.

These additional cases were confirmed serologically according to WHO criteria, and brings the cumulative number of human cases in Pakistan to 3. Egypt confirms its 48th human case in 8 Apr India reports H5N1 in backyard poultry in a new a 19-year-old man from Beheira 2008 province, Tripura. (onset date 30 March 2008). 11 Apr Russian Federation reports H5N1 in village 2008 poultry in Primorskiy Kray (first report since December, 2007). th 15 Apr Republic of Korea reports H5N1 in poultry in Egypt confirms its 49 human case in 2008 two new provinces (Cholla-Namdo and a 30-year-old woman from Cairo Ch’ungch’ong-Bukdo) (onset date 2 April 2008). th 17 Apr Egypt confirms its 50 human case in 2008 a 2-year-old boy from Sharkia (onset date 13 April 2008). 23 Apr Viet Nam continues to report outbreaks of

2008 H5N1 in poultry from several provinces. 24 Apr Bangladesh reports 156 outbreaks in commercial or backyard poultry in 6 provinces 2008 from 28 Dec 2007 through 14 Apr 2008 (Dhaka, Chittagong, Khulna, Rajshashi, Barasil, Sylhet) 29 Apr Japan reports H5N1 in 4 dead/ill wild swans in 2008 Akita prefecture (first report of H5N1 in birds in Japan since January 2007). rd 30 Apr Indonesia confirms its 133 human 2008 case in a 3-year-old boy from Central Java (onset date 14 April). 13 May Japan reports H5N1 in wild swans in Hokkaido

2008 prefecture. 20 May Republic of Korea reports outbreaks in poultry

2008 in 10 provinces. 28 May Bangladesh confirms it first human 2008 case, in a 16-month-old boy from Komalapur, Dhaka (onset date 27 Jan

2008). The case was identified retrospectively as part of seasonal influenza surveillance activities. 1 Jun Japan reports H5N1 in wild swans in Aomori

2008 prefecture. 3 Jun India reports H5N1 in backyard birds in West

2008 Bengal province United Kingdom reports highly pathogenic 6 Jun avian influenza H7N7 in a commercial flock of 25 This timeline is periodically updated. The last update was on: 25 January 2012

2008 chickens in England. 11 Jun Bangladesh reports H5N1 in commercial

2008 poultry in Dhaka 16 Jun According to FAO, HPAI remains endemic in Indonesia on the islands of Java, Sumatra, Bali, 2008 and South Sulawesi and sporadic outbreaks are reported from other areas. 31 th 19 Jun Indonesia confirms its 134 human 2008 case in a 16-year-old girl from DKI Jakarta (onset date 7 may 2008) and

135th human case, in a 34-year-old woman from Banten (onset date 26 May 2008). 20 Jun China reports H5N1 in poultry in Guandong 2008 (first report of H5N1 in birds in Guandong since March 2008). 26 Jun Pakistan reports outbreak of H5N1 in commercial poultry in North West Frontier 2008 province (first report of H5N1 in birds in Pakistan since March 2008). 7 Jul 2008 Egypt reports outbreaks in 9 governorates (Gharbiyah, Minufiyah, Kafr Ash Shaykh, Daqahliyah, Sharqiyah, Minya, Jizah, Suhaj, and Luxor) in commercial and backyard poultry, and

poultry in live bird markets, from 7 Feb to 14 Jun, 2008. In this report, the national veterinary Services (GOVS) declares H5N1 to be endemic in Egypt. 14 Jul Viet Nam reports 15 outbreaks in poultry in 9 2008 provinces throughout the country (Can Tho City, Ha Tinh, Kien Giang, Long An, Nghe An, Quang Ngai, Son La, Tra Vinh, Vinh Long)(first report of H5N1 in Viet Nam since April, 2008). 24 Jul Nigeria reports H5N1 infection in poultry in 4 states (Kebbi, Gombe, Katsina, and Kano). The 2008 two live bird market cases were detected through routine surveillance. 25 Jul FAO reports H5N1 in Indonesia, in village

2008 poultry in Bengkulu province32 25 Aug Benin reports H5 virus in chickens in a live 2008 animal market in Lokassa. These cases were detected as part of routine surveillance and training (first report of H5 in Benin since Dec, 2007). th 10 Sept Indonesia confirms its 136 human 2008 case in a 38-year-old man from Banten province (onset date 4 July

2008) and 137th human case, in a 20- year-old man from Banten (onset date 20 July 2008). 14 Sept Laos reports H5N1 in poultry in Luangprobang 2008 and Oudomxay provinces (first report of H5N1 in Laos since February, 2008). 18 Sept Togo reports H5N1 in poultry in the Région 2008 Maritime (first report of H5N1 in Togo since July 2007). 30 Sept Viet Nam reports 9 H5N1 outbreaks in poultry 2008 in 6 provinces throughout the country (Ben Tre, Ca Mau, Dong Thap, Kien Giang, Nghe An, and 26 This timeline is periodically updated. The last update was on: 25 January 2012

Quang Ngai) from July –April 2008. 10 Oct Germany reports H5N1 in poultry on a farm in 2008 Sachen (first report of H5N1 in Germany since January 2008) 15 Oct Russian Federation retrospectively reports two 2008 outbreaks from 2007, in February in Moskovskaya and in December in Rostovskaya. 10 Nov Laos reports H5N1 in backyard chickens in one 2008 additional province (Xayabury)

Thailand reports H5N1 in backyard poultry in Sukhothai province (first report of H5N1 in Thailand since January 2008) 11 Nov Thailand reports an additional H5N1 outbreak

2008 in poultry in a new province, Uthai Thani 20 Nov Bangladesh reports H5N1 in commercial poultry in Rajshahi district from September, 2008 2008 (First report of H5N1 in Bangladesh since June 2008). 27 Nov Viet Nam reports H5N1 in Nghe An province. 2008 28 Nov India reports H5N1 in village poultry in Assam 2008 province (First report of H5N1 in India since May 2008) 1 Dec Lao PDR retrospectively reports H5N1 in Luangnamtha province from February 2008 2008 (more recent outbreaks were reported in October, 2008) 3 Dec Bangladesh Ministry of Fisheries and Livestock 2008 reports a new H5N1 outbreak in poultry in Rajshahi district (Rangpur sub-district). th 9 Dec Indonesia confirms its 138 human 2008 case in a 9-year-old girl from Riau province (onset date 7 November 2008) and 139th human case in a 2- year-old girl from East Jakarta province (onset date 18 November 2008). 11 Dec India reports additional H5N1 outbreaks in 2008 backyard and commercial poultry in several districts of Assam province. th 12 Dec Cambodia confirms its 8 human 2008 Hong Kong (China SAR) reports an H5N1 case in a 19- year-old man from outbreak in commercial poultry in Yuen Long Kandal province (onset date 28 (first report of H5N1 in commercial poultry in November 2008). This is the first Hong Kong since 2002). non-fatal case of human H5N1 infection in Cambodia. st 16 Dec Egypt confirms it 51 human case, in a 16-year-old girl from Assuit 2008 Governorate (onset date, 8 December 2008). 17 Dec India reports H5N1 outbreaks in backyard 2008 poultry in a new province, West Bengal province.

Bangladesh reports H5N1 outbreaks in commercial poultry in a new district, Dhaka district. China reports H5N1 outbreaks in poultry in 19 Dec Jiangsu province (first outbreak reported by 27 This timeline is periodically updated. The last update was on: 25 January 2012

2008 China since June, 2008, in Guangdong)

According to the Update on the Avian Influenza Situation (Issue No. 182) in Cambodia, ducks were confirmed H5N1 positive in Kandal province33 (first outbreak reported by Cambodia since April 2007). 29 Dec Viet Nam reports an H5N1 outbreak in poultry

2008 in a new province, Thai Nguyen province. 2 Jan The H5N1 virus continues to cause outbreaks in 2008 poultry in Assam and West Bengal provinces in India. 4 Jan The Bangladesh Ministry of Fisheries and 2009 Livestock reports new H5N1 outbreaks in poultry in Rajshahi district. st 7 Jan China confirms its 31 human case, 2009 in a 19-year-old woman from Beijing Viet Nam reports an H5N1 outbreak in poultry (onset date 24 December 2008). in a new province, Thanh Hoa province (outbreak detected after confirmation of human Viet Nam confirms its 107th human case). case, in a 8-year-old girl from Thanh Hoa province (onset date 27 December 2008). nd 14 Jan Egypt confirms it 52 human case, in a 21-month-old girl from 6th October 2009 governorate (onset date 9 January 2009). 15 Jan According to FAO, in Indonesia, HPAI remains endemic on Java, Sumatra, and Sulawesi 2009 Islands with sporadic outbreaks reported from other areas. 34 16 Jan Nepal reports an H5N1 outbreak in backyard 2009 poultry in Mechi province (first ever report of H5N1 from Nepal. nd 19 Jan China confirms its 32 human case, 2009 in a 27-year-old woman from Shandong province (onset date 5 January 2009), its 33rd human case, in a 2-year-old girl reported from Shanxi province who was likely exposed in Hunan province (onset date 7 January 2009), and its 34th human case, in a 16-year-old man who sought care in Hunan province and who was likely exposed in Guizhou province (onset date 8 January 2009).

21 Jan India reports H5N1 outbreaks in poultry in a

2009 new province, Sikkim Bangladesh reports H5N1 outbreaks in poultry 22 Jan Indonesia confirms its 140th case, in a in a new district, Chittagong (last report from 2009 29- year-old woman from Banten this district in April 2008) province (onset date 11 December

2008) and its 141st case, in a 5-year- FAO reports outbreaks of H5N1 in Egypt, in old girl from West Java province backyard poultry in Assuit and Fayoum (onset date 23 December 2008). governorates. rd 26 Jan Egypt confirms its 53 human case, 2009 in a 2-year-old girl from Manofia governorate.

28 This timeline is periodically updated. The last update was on: 25 January 2012

th 27 Jan China confirms its 35 human case, 2009 in a 31-year-old woman from Xinjiang Autonomous Region (onset date 10 January 2009), its 36th human case, in a 29-year-old man from

Guizhou province (onset date 15 January 2009), and its 37th human case, in a 18-year-old man from Guanxi province (onset date 10 January 2009). China confirms its 38th human case, 2 Feb India reports additional H5N1 outbreaks in in a 21-year-old woman from Hunan 2009 backyard poultry in new areas of West Bengal province (onset date 23 January province 2009). 3 Feb Bangladesh reports additional H5N1 outbreaks 2009 in backyard poultry in Rajshahi province.

Viet Nam reports H5N1 outbreaks in poultry in Ca Mau province (first outbreak in this province since September 2008). th 5 Feb Egypt confirms its 54 human case, 2009 in a 2-year-old boy from Suez governorate. 6 Feb Viet Nam reports additional H5N1 outbreaks in 2009 poultry in Ca Mau province and new outbreaks in Soc Trang and Nghe An provinces. th 9 Feb Egypt confirms its 55 human case, in a 18-month-old boy from Menia 2009 governorate (onset date 6 February 2009). 10 Feb China reports an H5N1 outbreak in poultry in 2009 Xinjiang Autonomous Region (first outbreaks in this region since December 2007)

Bangladesh reports an additional H5N1 outbreak in a commercial poultry farm in Dhaka district. th 11 Feb Viet Nam confirms its 108 human case, in a 23-year-old woman from 2009 Quang Ninh province (onset date 28 January 2009). 13 Feb FAO reports outbreaks of H5N1 in Egypt, in 2009 backyard poultry in Sharkia, Beheira, Helwan, and Fayoum governorates.

Hong Kong China SAR reports H5N1 in wild migratory and local birds as well as commercial poultry on the coast. 16 Feb Viet Nam reports new or ongoing H5N1 outbreaks in commercial and village poultry in 2009 Bac Ninh, Ca Mau, Hau Giang, Quang Ninh, Quang Tri, and Soc Trang provinces. th 18 Feb Viet Nam confirms its 109 human case, in a 32-year-old man from Ninh 2009 Binh province (onset date 5 February 2009). 19 Feb India reports additional outbreaks in backyard

2009 poultry in West Bengal province. 20 Feb Nepal reports a second H5N1 outbreak in

2009 backyard poultry in Mechi province. 29 This timeline is periodically updated. The last update was on: 25 January 2012

22 Feb Viet Nam reports new or ongoing H5N1 2009 outbreaks in poultry in Bac Lieu, Khanh Hoa, Ninh Binh, and Quang Ninh, provinces. 26 Feb Lao PDR reports a new outbreak of H5N1 in 2009 poultry in Phongsaly province (first report from Lao PDR since October, 2008) 26 Feb Bangladesh reports ongoing H5N1 outbreaks in backyard poultry and commercial farms in 2009 Dhaka district, and the MoH reports new outbreaks in Rajshahi and Chittagong districts. th 2 Mar Egypt confirms its 56 human case, in a two-year-old boy from Fayoum 2009 governorate (onset date 25 February 2009). th 10 Mar Egypt confirms its 57 human case, 2009 Germany reports H5N1 in a single wild bird in a two and a half-year-old boy from hunted in January, 2009 in Bayern province. Alexandria governorate (onset date 3 March 2009). th 11 Mar Egypt confirms its 58 human case, in a one and a half-year-old girl from 2009 Menofia governorate (onset date 6 March 2009). 18 Mar Egypt reports outbreaks of H5N1 in mostly 2009 backyard poultry in February and March in Alexandria, Assiut, Aswan, Beheira, Fayoum,

Gharbia, Giza, Helwan, Menoufiya; Minya, Sharkia, Sixth of October, and Suez governorates through the SAIDR website.35 th 23 Mar Egypt confirms its 59 human case, in a 38-year-old woman from Assiut 2009 governorate (onset date 14 March 2009). th 30 Mar Egypt confirms its 60 human case, in a 3-year-old girl from Qena 2009 governorate (onset date 23 March 2009). st nd 8 Apr Egypt confirms its 61 and 62 2009 human cases, in two 2-year-old boys from Kom Hamada district, Beheira governorate (onset dates 27 and 31 March 2009). Investigation of close contacts did not reveal any other people with symptoms of the infection. Egypt also confirmed its

63rd human case, in a 6-year-old boy from Qalubiya governorate (onset date 22 March 2009).

Viet Nam confirms its 110th human case, in a 3-year-old boy from Dong Thap province (onset date 12 March 2009). 10 Apr Viet Nam reports new or ongoing H5N1 2009 outbreaks in poultry in Lai Chau and Quang Ninh provinces. 13 Apr Bangladesh reports new or ongoing H5N1 outbreaks in commercial and backyard poultry in 2009 Barisal, Chittagong, Dhaka, and Rajshahi Districts. China Hong Kong SAR reports H5N1 in 16 Apr poultry and a wild bird in Ping Chau. 30 This timeline is periodically updated. The last update was on: 25 January 2012

2009 th 17 Apr Egypt confirms its 64 human case, in a 33-year-old woman from Kefr El 2009 Sheikh governorate (onset date 7 April 2009). 19 Apr China reports H5N1 in birds in a live chicken 2009 market in the Xizang Autonomous Region (Tibet). th 21 Apr Egypt confirms its 65 human case, 2009 in a 25-year-old woman from Cairo (onset date 6 April 2009) and its 66th

human case, in a 18-month-old girl from Kefr El Sheikh governorate (onset date 15 April 2009). th 23 Apr Egypt confirms its 67 human case, in a 4-year-old boy from Sohag 2009 governorate (onset date 18 April 2009). th 6 May Viet Nam confirms its 111 human 2009 case, in a 23-year-old woman from Thanh Hoa province (onset date 16 April 2009).

Egypt confirms its 68th human case, in a 34-year-old woman from Gharbia governorate (onset date 21 April 2009). th 15 May Egypt confirms its 69 human case, 2009 in a 5-year-old girl from Sohag governorate (onset date 7 May 2009) 17 May China reports H5N1 in dead wild birds in

2009 Qinghai province. 21 May Viet Nam reports new or ongoing H5N1 2009 outbreaks in poultry in Dong Thap, Quang Ngai, Thanh Hoa, and Vinh Long provinces. th 22 May Egypt confirms its 70 human case, 2009 in a 4-year-old boy from Sharkia governorate (onset date 10 May 2009), its 71st human case, in a 3- year-old boy from Gharbia governorate (onset date 12 May 2009), its 72nd human case, in a 4- year-old girl from Dakhlia governorate (onset date 9 May 2009), its 73rd human case, in a 4-year-old boy from Dakhlia governorate (onset date 18 May 2009), and its 74th human case, in a 3-year-old boy from Sohag governorate (onset date 17 May 2009). 27 May India reports continuing outbreaks of H5N1 in

2009 rural backyard poultry in West Bengal province. th 28 May Egypt confirms its 75 human case, 2009 in a 4-year-old boy from Hehia Mongolia reports H5N1 in wild migratory swans district (onset date 24 May 2009) and (first report of H5N1 in Mongolia since May its 76th human case, in a 4-year-old 2006). girl from Abo Hammad district (onset date 23 May 2009), both in Sharkia governorate.

31 This timeline is periodically updated. The last update was on: 25 January 2012

th 1 Jun Egypt confirms its 77 human case, in a 1-year-old girl from Dakhlia 2009 governorate (onset date 25 May 2009). th 2 Jun Egypt confirms its 78 human case, in a 4-year-old girl from Kefr El 2009 Sheikh governorate (onset date 30 May 2009). 17 Jun Bangladesh reports new or ongoing H5N1 2009 outbreaks in commercial poultry in Dhaka and Chittagong provinces. 24 Jun Russian Federation reports H5N1 in wild birds 2009 in the Tyva republic (first report of H5N1 from the Russian Federation since April 2008). 26 Jun Viet Nam reports new or ongoing H5N1 2009 outbreaks in household poultry in Quang Ninh province. 30 Jun According to FAO, in Indonesia, HPAI remains endemic on Java, Sumatra, and Sulawesi 2009 Islands with sporadic outbreaks reported from other areas.36 th 1 Jul 2009 Egypt confirms its 79 human case, in a 1-year-old boy from Domiatt Governorate (onset date 1 June 2009), its 80th human case, in a 4-year-old girl from Dakhlia governorate (onset date 5 June 2009), and its 81st human case, in a 1 year old boy from Kefr El Sheikh governorate (onset date 15 June 2009). 14 Jul Bangladesh reports ongoing H5N1 outbreaks in

2009 commercial poultry in Chittagong province. 24 Jul Egypt has reported outbreaks of H5N1, mostly 2009 in household poultry, between April and July in Alexandria, Beheira, Beni Suef, Dakahlia, Damietta, Fayoum, Gharbia, Giza, Kafr el

Sheikh, Luxor, Menoufiya, Minya, Port Said, Qaliyoubia, Sharkia, Sixth of October, Sohag and Suez governorates through the SAIDR website. 37 10 Aug Mongolia reports additional outbreaks of H5N1

2009 in wild birds in Arkhangai. nd 11 Aug Egypt confirms its 82 human case, 2009 in a 8-year-old girl from Kefr El Sheikh governorate (onset date 24

July 2009) and its 83rd human case, in a 18-month-old boy from Menofia governorate (onset date 28 July 2009). th 31 Aug Egypt confirms its 84 human case, 2009 in a 2-year-old girl from Menofia governorate (onset date 23 August 2009) and its 85th human case, in a 14-year-old girl from Damietta governorate (onset date 21 August 2009). 31 Aug FAO reports that 134 (6.8%) of villages under 2009 surveillance in Indonesia were positive for H5N1 in poultry, and confirms the virus to be endemic on the islands of Java, Sumatra and Sulawesi, and probably Bali, with sporadic 32 This timeline is periodically updated. The last update was on: 25 January 2012

outbreaks reported elsewhere. 38 20 Sep Bangladesh reports ongoing H5N1 outbreaks in

2009 commercial poultry in Chittagong province. th 24 Sep Egypt confirms its 86 human case, 2009 in a 13-year-old boy from Alexandria governorate (onset date 13 September 2009) and its 87th human case, in a one-year-old girl from Beheira governorate (onset date 23 September 2009) 29 Oct FAO reports 104 outbreaks of H1N1 in poultry 2009 in Indonesia during September, especially concentrated in provinces on Java Island39 5 Nov The Russian Federation reports H5N1 in a wild 2009 bird in Moskovskaya Oblast.

Viet Nam reports H5N1 in birds in Dien Bien province. This is the first outbreak reported from Viet Nam since June 2009. th 20 Nov Egypt confirms its 88 human case, in a 21-year-old man from Alexandria 2009 governorate (onset date 11 November 2009). th 27 Nov Egypt confirms its 89 human case, in a 3-year-old boy from Menia 2009 governorate (onset date 21 November 2009). th 11 Dec Viet Nam confirms its 112 human 2009 case, in a man from Dien Bien province (onset date 18 November, 2009). This is the first case reported from Viet Nam since April 2009. 13 Dec Viet Nam reports H5N1 in birds in Ca Mau

2009 province. 16 Dec Viet Nam reports H5N1 in birds in Thai Nguyen

2009 province. th 18 Dec Cambodia confirms its 9 human 2009 case, in a 57-year-old man from Kampong Cham Province (onset date

11 December 2009). This is the first human case reported from Cambodia since November 2008. th 21 Dec Egypt confirms its 90 human case, in a 21-year-old woman from Gharbia 2009 governorate (onset date 15 December 2009). 27 Dec Viet Nam reports H5N1 in birds in Cao Bang

2009 province. 28 Dec Cambodia reports H5N1 in backyard poultry in Kampong Cham Province. This is the first 2009 outbreak reported from Cambodia since December 2008. 29 Dec Indonesia confirms 21 human cases 2009 with onset dates in 2009; a 26-year- old woman from West Java (onset date 9 January); a 14-year-old girl from West Java (onset date 13 January); a 21-year-old woman from East Java (onset date 16 January); a 33 This timeline is periodically updated. The last update was on: 25 January 2012

30-year-old man from West Java (onset date 20 January); a 12-year-old boy from DKI Jakarta (onset date 24 January); a 3-year-old girl from Banten (onset date 6 February); a 42- year-old man from West Java (onset date 14 February); a 5-year-old girl from West Java (onset date 18 February); a 8-year-old boy from West Java (onset date 18 February); a 4-year-old girl from DKI Jakarta (onset date 25 February); a 2-year-old boy from Riau (onset date 9 March); a 5 ½-year-old girl from DKI Jakarta (onset date 21 March); a 24-year-old woman from Yogyakarta (onset date 7 April); a 24-year-old woman from DKI Jakarta (onset date 14 May); a 27-year-old woman from DKI Jakarta (onset date 18 May); a 1-year-old girl from DKI Jakarta (onset date 26 May); a 5-year-old boy from DKI Jakarta (onset date 8 June); a 16-year- old girl from DKI Jakarta (onset date 12 June); a 43-year-old woman from East Java (onset date 18 September); a 31-year-old man from DKI Jakarta (onset date 24 September), and a 3- year-old boy from DKI Jakarta (onset date 3 December). 4 Jan Egypt has reported outbreaks of H5N1, mostly 2010 in household poultry, between August and December 2009 in Assuit, Beheira, Beni Suef, Dakahlia, Fayoum, Gharbia, Kafr el Sheikh, Menoufiya, Minya, Port Said, Qaliyoubia, Sharkia, and Suez governorates through the SAIDR website. 37 5 Jan China Hong Kong SAR reports a H5N1- 2010 positive Oriental Magpie Robin (resident species) in Hok Tau. 15 Jan India reports outbreaks of H5N1 in backyard 2010 poultry in West Bengal (first report of H5N1 in India since May of 2009). 20 Jan Bangladesh reports outbreaks of H5N1 in 2010 poultry in Rajshahi (first report of H5N1 in Bangladesh since September of 2009). 21 Jan FAO reports that 135 (7.0%) of villages under 2010 surveillance in Indonesia in December 2009 were positive for H5N1 in poultry. Infected villages were detected in Kalimantan Selatan and Kalimantan Tengah for the first time. 40 24 Jan Viet Nam reports outbreaks of H5N1 in poultry

2010 in Ha Tinh province. 26 Jan Israel reports outbreaks of H5N1 in commercial 2010 poultry in Haifa (first report of H5N1 in Israel since January 2008). st 28 Jan India reports additional outbreaks of H5N1 in Egypt confirms its 91 human case, 2010 backyard poultry in West Bengal. in a 20-year-old woman from Beni Suef Governorate (onset date 6 Viet Nam reports outbreaks of H5N1 in poultry January 2010), its 92nd human case, in

34 This timeline is periodically updated. The last update was on: 25 January 2012

in two additional provinces, Dien Bien and Soc a 1-year-old boy from Dakahlia Trang. Governorate (onset date 7 January 2010), its 93rd human case, in a 3- year-old boy from Assuit Governorate (onset date 21 January 2010), and its 94th human case, in a 45-year-old man from Sharkia Governorate (onset date 19 January 2010). 31 Jan Bangladesh reports additional outbreaks of 2010 H5N1 in commercial poultry in Rajshahi province. 5 Feb Cambodia reports outbreaks of H5N1 in poultry 2010 in Takeo province.

Myanmar reports outbreaks of H5N1 in commercial chickens in Yangon. This is the first outbreak reported from Myanmar since

December 2007.

Nepal reports outbreaks of H5N1 in backyard and commercial chickens and ducks in Gandaki Province. This is the first outbreak reported from Nepal since February 2009. th 8 Feb Egypt confirms its 95 human case, 2010 in a 40-year-old woman from Qalyubiya Governorate (onset date 31 January 2010) and its 96th human case, in a 29-year-old woman from Menoufiya Governorate (onset date 27 January 2010). th 10 Feb Egypt confirms its 97 human case, in a 37-year-old man from Helwan 2010 Governorate (onset date 31 January 2010). 11 Feb India reports additional outbreaks of H5N1 in

2010 backyard poultry in West Bengal. rd 12 Feb Indonesia confirms its 163 human 2010 case, in a 25-year-old woman from DKI Jakarta province. 13 Feb Viet Nam reports H5N1 in poultry in additional 2010 provinces (Ha Tinh, Kon Tum, Nam Dinh, Nge An, and Quang Tri). th 17 Feb Egypt confirms its 98 human case, 2010 in a 32-year-old man from Ashmon district, Menoufiya Governorate and its 99th human case, in a 29-year-old woman from ElSadat district Menoufiya Governorate (both had onset date 6 February 2010). 18 Feb Egypt has reported outbreaks of H5N1, mostly 2010 in household poultry, between 1 January and 10 February 2010 in Alexandria, Beheira, Beni Suef, Dakahlia, Fayoum, Gharbia, Helwan; Kafr el Sheikh, Menoufiya, Minya, Port Said, Qaliyoubia, Sharkia, and 6th October governorates through the SAIDR website. 37 22 Feb Myanmar reports additional outbreaks of H5N1,

2010 now in household poultry, in Yangon. Bhutan reports outbreaks of H5N1 in poultry in 23 Feb two villages in Chhukha. This is the first ever 35 This timeline is periodically updated. The last update was on: 25 January 2012

2010 report of H5N1 in Bhutan. 25 Feb Egypt has reported outbreaks of H5N1, mostly 2010 in household poultry, between 11 and 25 February 2010 in Alexandria, Beheira, Beni Suef, Dakahlia, Damietta, Fayoum, Gharbia,

Giza, Helwan; Ismailia, Kafr el Sheikh, Luxor, Menoufiya, Minya, New Valley, Suez, Qaliyoubia, Sharkia, and 6th October governorates through the SAIDR website. 37 2 Mar Bangladesh reports outbreaks of H5N1 in 2010 poultry in Chittagong, Dhaka, and Rajshahi provinces. 3 Mar Viet Nam reports outbreaks of H5N1 in poultry 2010 in Ca Mau, Ha Giang, Khanh Hoa, Nge An, and Tuyen Quang provinces. th 4 Mar Egypt confirms its 100 human case, 2010 in a 53-year-old man from Shobra Elkhima district, Qaliyoubia governorate (onset date 27 February), its 101st human case, in a 1-year-old boy from Banha district, Qaliyoubia governorate (onset date 22 February), its 102nd human case, in a 10-year-old boy from Meet Ghamr district, Dakahlia Governorate (onset date 10 February), its 103rd human case, in a 30-year-old woman from Kellin District, Kafr el Sheikh Governorate (onset date 10 February), and its 104th human case, in a 13-year-old boy from Kafr el Sheikh District, Kafr el Sheikh Governorate (onset date 10 February).

Viet Nam confirms its 113th human case, in a 3-year-old girl from Ninh Hoa District, Khanh Hoa Province (onset date 27 January), its 114th human case, in a 38-year-old woman from Cai Be District, Tien Giang Province (onset date 13 February), and its 115th human case in a 17-year- old girl from Son Duong District, Tuyen Quang Province (onset date 19 February).

5 Mar Myanmar reports outbreaks of H5N1 in poultry

2010 in a new province, Sagaing. th 12 Mar Egypt confirms its 105 human case, 2010 in a 20-year-old woman from El Khanka district, Qaliyoubia governorate (hospitalization date 5

March) and its 106th human case, in a 1 ½ -year-old boy from El Hamool district, Kafr el Sheikh governorate (hospitalization date 2 March). 14 Mar Nepal reports outbreaks of H5N1 in household

2010 poultry in 3 new provinces (Lumnini, Narayani, 36 This timeline is periodically updated. The last update was on: 25 January 2012

and Rapti). Viet Nam confirms its 116th human 16 Mar Romania reports outbreaks of H5N1 in case, in a 25-year-old woman from 2010 backyard poultry in Tulcea province. (first report Soc Son district, Hanoi (onset date 5 of H5N1 in Romania since November 2007). March). 24 Mar Viet Nam reports outbreaks of H5N1 in poultry 2010 in Bac Ninh, Ben Tre, Nghe An, Quang Ninh, and Tuyen Quang provinces. 25 Mar Bhutan reports additional outbreaks of H5N1 in

2010 poultry in Chhukha. 28 Mar Nepal reports outbreaks of H5N1 in household

2010 poultry in 2 new provinces, Seti and Lumbini. th 29 Mar Viet Nam confirms its 117 human case, in a 3-year-old girl from Thuan 2010 An district, Binh Duong province (onset date 5 March). Egypt confirms its 107th human case, 30 Mar Egypt has reported outbreaks of H5N1, mostly in a 30-year-old woman from 2010 in household poultry, from 26 February through Damietta district, Damietta 30 March 2010 in Alexandria, Aswan, Beni governorate (onset date 28 March) Suef, Dakahlia, Fayoum, Gharbia, Giza, Helwan; and its 108th human case, in a 4-year- Kafr el Sheikh, Menoufiya, Menia, Sharkia, old boy from Beba district, Beni Suef Suez, Qaliyoubia, and 6th of October governorate (hospitalization date 18 governorates through the SAIDR website. 37 March). 1 Apr Bulgaria reports H5N1 in a wild common 2010 buzzard in Varna (first report of H5N1 since 2006, previously also in a wild bird). 7 Apr China Hong Kong SAR reports a H5N1- positive barn swallow (Hirundo rustica) in Yuen 2010 Long (first report of H5N1 in Hong Kong since January 2010, also in a wild bird). th 9 Apr Egypt confirms its 109 human case, in a 18-year-old woman from Etsa 2010 district, Fayoum governorate (onset date 31 March). 10 Apr Viet Nam reports outbreaks of H5N1 in poultry

2010 in Bac Kan and Quang Ninh provinces. th 21 Apr Viet Nam confirms its 118 human 2010 case, in a 22-year-old man from Nhu Co commune (onset date 28 March), and its 119th human case, in a 2-year- old girl from Cho Moi district (onset date 2 April), both in Bac Kan province. 25 Apr Bangladesh reports continued outbreaks of 2010 H5N1 in commercial and backyard poultry in Chittagong, Dhaka, and Rajshahi provinces. 29 Apr Viet Nam reports outbreaks of H5N1 in poultry 2010 in Quang Ngai, Quang Ninh, and Quang Tri provinces. 1 May Cambodia reports outbreaks of H5N1 in village

2010 poultry in Prey Veng province. th 4 May Cambodia confirms its 10 human 2010 case, in a 27-year-old man from Prey Veng province (onset date 13 April).

This is the first human case reported from Cambodia since December 2009.

37 This timeline is periodically updated. The last update was on: 25 January 2012

6 May Egypt has reported outbreaks of H5N1, mostly in household poultry, from 31 March through 6 2010 Indonesia confirms its 164th human May 2010 in Beheira, Beni Suef, Dakahlia, case, in a 45-year-old woman from Damietta, Fayoum, Gharbia, Helwan; Kafr el Malang city in East Java province Sheikh, Luxor, Menoufiya, Menia, Port Said, (onset date 22 February) and its 165th Suez, Qaliyoubia, Qena, and 6th of October human case, in a 4-year-old girl from governorates through the SAIDR website. 37 Pekanbaru city in Riau province

(onset date 19 April). Israel reports H5N1 in a variety of birds, including emus, in a minizoo in Hadarom. 10 May Mongolia reports H5N1 in wild whooper swans Cygnus ٛ ospit) and ٛ ospita geese (Anser) 2010 anser) in Sukhbaatar (first report of H5N1 in Mongolia since August 2009). 14 May Lao PDR reports H5N1 in commercial poultry 2010 in Vientiane (first report of H5N1 from Lao PDR since February 2009). 15 May FAO reports that, during March 2010, the 2010 overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 1.5 newly found infected villages per 1000 villages in the

coverage area, with incidence rates varying widely among provinces. Incidence rates were highest in Kepulauan Bangka Belitung, Yogyakarta, Lampung, and Jambi provinces. 41 20 May Bangladesh reports H5N1 in poultry in Rajshahi

2010 district. 28 May Egypt has reported outbreaks of H5N1, mostly 2010 in household poultry, from 7 May through 28 May 2010 in Beheira, Beni Suef, Cairo, Dakahlia, Fayoum, Gharbia, Helwan; Luxor, Menoufiya, Port Said, Sharkia, and 6th of October governorates through the SAIDR website. 37 4 Jun FAO reports that, during April 2010, the overall 2010 HPAI incidence in Indonesia based on Participatory Disease Surveillance and Response (PDSR) village-level surveillance was 1 newly found infected village per 1000 villages in the

coverage area, with incidence rates continuing to vary widely among provinces. Incidence rates were highest in Kepulauan Bangka Belitung, Yogyakarta, Lampung, and Jawa Tengah provinces. 42 th 8 Jun China confirms its 39 human case, 2010 in a 22-year-old woman from Hubei province (onset date 23 May). This is the first human case reported from China since February 2009. 25 Jun The Russian Federation reports H5N1 in wild birds in the Tyva republic (first report of H5N1 2010 in the Russian Federation since November 2009, also in a wild bird). 1 Jul 2010 FAO reports H5N1 in poultry in Narayanganj district, Bangladesh.43

FAO reports H5N1 in poultry in Thai Nguyen City, Thai Nguyen province, Viet Nam.43 China reports H5N1 in wild birds in Shuanglu 2 Jul 2010 district, Tibet (first report of H5N1 in China 38 This timeline is periodically updated. The last update was on: 25 January 2012

since June 2009, in Qinghai province, also in wild birds). th 5 Jul 2010 Indonesia confirms its 166 human case, in a 34-year-old woman from

South Jakarta district, DKI Jakarta province (onset date 25 May). 8 Jul 2010 FAO reports that, during May 2010, the overall HPAI incidence in Indonesia based on Participatory Disease Surveillance and Response (PDSR) village-level surveillance was 0.6 per 1000 villages under surveillance. This month, there was very little variation in incidence between provinces and few newly infected villages reported. The highest incidence occurred in Yogyakarta. New outbreaks were identified in nine out of 23 provinces visited in Sumatera, Java and Kalimantan Islands. 44 11 Jul Egypt has reported outbreaks of H5N1, mostly 2010 in household poultry, from 30 May through 11 July 2010 in Dakahlia, Damietta, Fayoum,

Gharbia, Menoufiya, Minya, Qaliyoubia, Suez, and 6th of October governorates through the SAIDR website. 37 th 22 Jul Indonesia confirms its 167 human case, in a 13-year-old girl from 2010 Sukoharjo district, Central Java province (onset date 16 June). th 29 Jul Egypt confirms its 110 human case, in a 20-year-old woman from Shobra 2010 FAO reports H5N1 in poultry in Ia Grai district, Elkhima district, Qaliyoubia Gia Lai province, Viet Nam. 45 governorate (Hospitalization date 21 July). th 3 Aug Indonesia confirms its 168 human case, in a 34-year-old woman from 2010 Tangerang district, Banten province (onset date 2 July). th 12 Aug Egypt confirms its 111 human case, 2010 in a 2-year-old girl from El Salam district, Cairo (onset date 2 August). 17 Aug Viet Nam reports H5N1 in poultry in Dak Lak, Quang Nam, and Thai Nguyen provinces (event 2010 dates in May-June 2010), and confirms Gia Lai outbreak reported by FAO in July. 19 Aug FAO reports that, during June 2010, the overall 2010 HPAI incidence in Indonesia based on Participatory Disease Surveillance and Response (PDSR) village-level surveillance was 0.4 per 1000 villages under surveillance. There was very

little variation in incidence between provinces and few newly infected villages reported. The highest incidence occurred in Yogyakarta. New outbreaks were identified in Java, Kalimantan, Sulawesi and Sumatera. 46 27 Aug Egypt has reported outbreaks of H5N1, from 12 July through 27 August 2010, in poultry in Beni 2010 Suef and Menoufiya governorates through the SAIDR website. 37 th 31 Aug Egypt confirms its 112 human case, in a 33-year-old woman from 2010 Qaliyoubia governorate (onset date 17 August). 39 This timeline is periodically updated. The last update was on: 25 January 2012

23 Sept FAO reports that, during July 2010, the overall 2010 HPAI incidence in Indonesia based on PDSR village-level surveillance was 0.5 per 1000 villages under surveillance. The highest

incidence occurred in Bengkulu (Sumatera). New outbreaks were identified in Lampung, Aceh, Sumatera (Barat and Selatan), Java, Kalimantan and Sulawesi. 47 7 Oct FAO reports that, during August 2010, the 2010 overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 0.6 per 1000 villages under surveillance. The highest incidence occurred in Bengkulu (Sumatera). New outbreaks were identified in Java, East and West Kalimantan, South Sulawesi and southern Sumatera. 48

FAO reports that, during September through 3 October, outbreaks of H5N1 have occurred in Egypt in Beni Suef, Dakahlia, Giza, Fayoum, Menoufiya, and Qaliyoubia governorates. 48 th 18 Oct Indonesia confirms its 169 human 2010 case, in a 35-year-old man from West Jakarta, Jakarta province (onset date 16 August) and its 170th human case in a 40-year-old woman from Kota Depok, West Java province (onset date 9 September). 21 Oct FAO reports that outbreaks of H5N1 have 2010 occurred in poultry in Egypt in Alexandria, Beni Suef, Dakahlia, Fayoum, Gharbia, Kafr el Sheikh, Luxor, Menoufiya and 6th of October governorates in October. 49 28 Oct FAO reports that H5N1 virus was found in wild 2010 duck droppings during routine surveillance in Hokkaido prefecture, Japan, in October 2010. 50 4 Nov FAO reports that outbreaks of H5N1 have occurred in poultry in Egypt in Fayoum, 2010 Gharbia, Qena, Menoufiya, and Sharkia governorates in October. 51 18 Nov FAO reports that outbreaks of H5N1 have occurred in poultry in Egypt in Beni Suef, 2010 Gharbia, Menoufiya, Qaliyoubia, Qena, and 6th of October governorates in November. 52 th 19 Nov China confirms its 40 human case, in 59-year-old woman from Hong 2010 Kong SAR (onset date 2 November). Prior to implementing the current WHO system for counting cases of avian influenza H5N1 infections in humans, China Hong Kong SAR had reported 20 human cases (18 in 1997 and 2 in 2003; these 20 cases are not reported in the WHO cumulative table53). 30 Nov Japan reports H5N1 in commercial poultry in 2010 Yasugi city, Shimane prefecture. This is the first outbreak of H5N1 in Japanese poultry since 2007, although wild birds with H5N1 infection were reported in Japan in 2009. 2 Dec FAO reports that outbreaks of H5N1 have 40 This timeline is periodically updated. The last update was on: 25 January 2012

2010 occurred in poultry in Egypt in Alexandria, Gharbia, and Dakahlia governorates in November. 54

FAO reports that, during September 2010, the overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 0.7 per 1000 villages under surveillance. The highest incidence occurred in DI Yogyakarta.54 4 Dec Viet Nam reports H5N1 in poultry in Nam Dinh 2010 and Nghe An provinces (first report of H5N1 from Viet Nam since July 2010). 5 Dec Nepal reports H5N1 in commercial poultry in 2010 Chitwan, Narayani zone (first report of H5N1 from Nepal since March 2010). th 8 Dec Egypt confirms its 113 human case, 2010 FAO reports H5N1 in poultry in Ngoc Hien in a 30-year-old woman from Gharbia District, Ca Mau province, Viet Nam. 55 governorate (onset date 28 November). Indonesia confirms its 171st human 9 Dec Republic of Korea reports H5N1 in a wild bird case, in a 21-year-old woman from 2010 in Iksan City, Jeollabuk-do (first report of H5N1 Bandung City, West Java province from Republic of Korea since May, 2008). (onset date 14 November). 14 Dec Republic of Korea reports H5N1 in a wild bird

2010 in Seosan City, Chungcheongnam-do. 15 Dec Egypt reports H5N1, mostly in household 2010 poultry, between the end of November to mid- December in Dakahlia, Fayoum, Gharbia, Kafr el Sheikh, Menoufiya, Minya, and Qaliyoubia governorates through the SAIDR website 37. 20 Dec Japan reports H5N1 in captive wild birds in a

2010 park zoo in Takaoka City, Toyama prefecture. 21 Dec Japan reports H5N1 in a wild bird in a bird

2010 sanctuary in Tottori prefecture. 22 Dec Japan reports H5N1 in a migratory wild bird in 2010 Izumi City, Kagoshima prefecture.

China Hong Kong SAR reports H5N1in a chicken found on Lantau Island. th 29 Dec Egypt confirms its 114 human case, 2010 in a 28-year-old woman from Beheira governorate (onset date 12 December)

and its 115th human case in an 11- year-old girl from Luxor (onset date 18 December). 2 Jan Republic of Korea reports H5N1 in wild birds 2011 in Sacheon city, Gyeongsangnam-do and Haenam-gun, Jeollanam-do and in poultry in Cheonan City, Chungcheongnam-do and Iksan City, Jeollabuk-do. th 5 Jan Egypt confirms its 116 human case, 2011 in a 56-year-old woman from Sharkia governorate (onset date 22 FAO reports that, during November 2010, the December); its 117th human case in a overall HPAI incidence in Indonesia based on 25- year-old woman from Qena (onset PDSR village-level surveillance was 0.6 per date 19 December); its 118th human 1000 villages under surveillance.56 case, in a 27-year-old man from Ismailia (onset date 23 December); and its 119th case, in a 40-year old 41 This timeline is periodically updated. The last update was on: 25 January 2012

man from Dakahlia (onset date 25 December). 7 Jan Republic of Korea reports H5N1 in poultry in 2011 Yeongam-gum, Jeollanam-do and in a wild bird in in Sacheon city, Gyeongsangnam-do. 10 Jan Bangladesh reports H5N1 in commercial 2011 poultry in Dhaka district (first report of H5N1 in Bangladesh since May, 2010). th 13 Jan Egypt confirms its 120 human case, 2011 in a 10-year-old boy from Giza governorate (onset date 5 January). 16 Jan Egypt reports H5N1, mostly in household 2011 poultry, in the first half of January in Dakahlia, Fayoum, Gharbia, Luxor, Menoufiya, Minya, Qaliyoubia, Qena, Sharkia, and 6th of October governorates through the SAIDR website. 37 17 Jan Republic of Korea reports 23 outbreaks of 2011 H5N1 in poultry in Chungcheongnam-do, Gyeonggi-do, and Jeollanam-do. 18 Jan Myanmar reports H5N1 in poultry in Sittwe, Rakhine state (first report of H5N1 in Myanmar 2011 since March, 2010). FAO reports H5N1 also in a second farm in Rakhine state. 57 19 Jan Japan reports H5N1 in wild birds in Izumi City, 2011 Kagoshima prefecture and Koriyama City, Fukushima prefecture. st 20 Jan Egypt confirms its 121 human case, 2011 in a 1-year-old boy from Alexandria governorate (onset date12 January). 21 Jan China Hong Kong SAR reports H5N1in wild

2011 birds on Lantau Island and in Yuen Long. 23 Jan Japan reports H5N1 in several species of wild 2011 birds in Hokkaido prefecture and 2 outbreaks of H5N1 in poultry in Miyazaki prefecture. 28 Jan China Hong Kong SAR reports additional 2011 H5N1 in wild birds and in chicken carcasses found on Lantau Island.

Myanmar reports H5N1 in poultry on multiple farms and in markets in Sittwe, Rakhine State.

Republic of Korea reports 14 additional outbreaks of H5N1 in poultry in Chungcheongnam-do, Gyeonggi-do, Gyeongsangbuk-do, and Jeollanam-do. 31 Jan Egypt reports H5N1, mostly in household 2011 poultry, in the second half of January in Dakahlia, Fayoum, Gharbia, Kafr el Sheikh, Menoufiya, Minya, Sharkia, and 6th of October governorates through the SAIDR website. 37

China Hong Kong SAR reports H5N1 in additional chicken carcasses found on Lantau Island. Egypt confirms its 122nd human case, 2 Feb Japan reports 5 outbreaks of H5N1 in poultry in in a 7-year-old boy from Gharbia 2011 Aichi, Miyazaki, and Kagoshima prefectures. governorate (onset date 20 January). 3 Feb Bangladesh reports H5N1 in poultry in

2011 Narayangonj, Dhaka District.

42 This timeline is periodically updated. The last update was on: 25 January 2012

4 Feb Japan reports H5N1 in wild birds in Fukushima, 2011 Hokkaido, Hyogo, Kochi, Shimani, and Tottori prefectures.

Myanmar reports H5N1 in poultry in Shwebo, Sagaing State. 7 Feb China Hong Kong SAR reports H5N1 in an 2011 additional poultry carcass found on Lantau Island.

Cambodia reports H5N1 in village poultry in Kandal province (first report of H5N1 in Cambodia since May, 2010). 9 Feb Japan reports 4 outbreaks of H5N1 in poultry in th 2011 Miyazaki and Oita prefectures. Cambodia confirms its 11 human case, in a 5-year-old girl from Phnom FAO reports that, during December 2010, the Penh (onset date 29 January). This is overall HPAI incidence in Indonesia based on the first human case reported from PDSR village-level surveillance in 1662 villages Cambodia since May 2010. was 1.2 per 1000 villages under surveillance.58 11 Feb Republic of Korea reports an additional

2011 outbreak of H5N1 in poultry in Gyeonggi-do. 13 Feb Bangladesh reports outbreaks of H5N1 in commercial poultry in Rangpur district and 2011 additional outbreaks in commercial poultry in Dhaka district. 14 Feb Japan reports H5N1 in wild birds in Hokkaido,

2011 Miyazaki, Nagasaki and Yamaguchi prefectures. 17 Feb India reports H5N1 in poultry in Tripura (first 2011 report of H5N1 in India since February, 2010).

Japan reports 3 additional outbreaks of H5N1 in poultry in Miyazaki prefecture. 18 Feb Republic of Korea reports 2 additional

2011 outbreaks of H5N1 in poultry in Gyeonggi-do. 23 Feb Viet Nam reports H5N1 in poultry in Ca Mau,

2011 Kon Tum, Lang Son and Nam Dinh provinces. 24 Feb Bangladesh reports outbreaks of H5N1 in 2011 commercial poultry in Chittagong, Khulna, and Sylhet districts and additional outbreaks in commercial poultry in Dhaka and Rangpur districts.

Japan reports H5N1 in wild birds in Fukushima, Hokkaido, Hyogo, Kagoshima, Kyoto, Miyazaki, Nagasaki, Oita, Tochigi, Tokushima, and Yamaguchi prefectures, and 4 outbreaks of H5N1 in poultry in Aichi, Mie, Miyazaki, and Wakayama prefectures. th th 25 Feb Cambodia confirms its 12 and 13 2011 human cases, in a 19-year-old woman and her 11-month-old son. The family lived in Banteay Meanchey Province,

but were believed to have been exposed to sick poultry in Prey Veng province. Both had disease onset on 5 February. rd 28 Feb Egypt reports H5N1, mostly in household Egypt confirms its 123 human case, poultry, in February in Beheira, Beni Suef, in a 26-year old woman from 43 This timeline is periodically updated. The last update was on: 25 January 2012

2011 Dakahlia, Fayoum, Gharbia, Kafr el Sheikh, Dakahlia governorate (onset date 18 Menoufiya, Minya, and 6th of October January), its 124th human case, in a governorates through the SAIDR website. 37 45-year-old man from Menoufiya governorate (onset date 20 January), and its 125th human case, in a 4-year- old boy from Damietta governorate (onset date 14 February). nd 2 Mar Indonesia confirms its 172 human case, in a 26-year-old woman from 2011 Karawang district, West Java province (onset date 30 January). 3 Mar West Bank/Gaza Strip reports H5N1 in poultry 2011 in Jenin, West Bank (first report of H5N1 in West Bank since April 2006).

Japan reports H5N1 in wild birds in Hokkaido, Hyogo, Miyazaki, Nagasaki, and Tottori prefectures. 4 Mar Myanmar reports additional outbreaks of H5N1 2011 in poultry in Shwebo, Sagaing State.

China Hong Kong SAR reports H5N1 in an additional poultry carcass found on Lantau

Island.

Republic of Korea reports 5 additional outbreaks of H5N1 in poultry in Gyeonggi-do, Gyeongsangnam-do, and Jeollanam-do. 6 Mar Bangladesh reports 29 outbreaks of H5N1 in 2011 Barisal, Chittagong, Dhaka, Khulna, and Rajshahi districts. th 7 Mar India reports an additional outbreak of H5N1 in Egypt confirms its 126 human case, 2011 poultry in Tripura. in a 32-year old woman from Sharkia governorate (onset date 10 February), Israel reports an outbreak of H5N1 in poultry in and its 127th human case, in a 2-year- Jehuda & Samaria (first report of H5N1 in Israel old boy from Kafr el Sheikh since May 2010) governorate (onset date 18 February). 8 Mar Viet Nam reports H5N1 in poultry in Ha Nam

2011 and Quang Ninh provinces. th 10 Mar Egypt confirms its 128 human case, 2011 in a 17-year old woman from Beheira governorate (onset date 27 February),

and its 129th human case, in a 17- year-old woman from Dakahlia governorate (onset date 24 February). 11 March Japan reports H5N1 in poultry on farms in Mie,

2011 Mayizaki, and Nara prefectures. rd 14 March Indonesia confirms its 173 human 2011 case, in a 2-year-old boy from Depok City, West Java province (onset date 3 February) and its 174th human case, in a 31-year-old woman from Bekasi City, West Java province (onset date 23 February). th 15 March Egypt confirms its 130 human case, 2011 in a 38-year-old woman from Ismailia governorate (onset date 1 March) Bangladesh confirms its 2nd human 16 March Japan reports H5N1 in wild birds in Aomori and case, in a 1-year-old girl from 2011 Shimane prefectures. Kamalapur, Dhaka (onset date 8 44 This timeline is periodically updated. The last update was on: 25 January 2012

March). This is the first human case reported in Bangladesh since May of 2008. 17 March Republic of Korea reports 2 additional 2011 outbreaks of H5N1 in poultry in Chungcheongnam-do and Gyeonggi-do.

FAO reports that, during January 2010, the

overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 1.9 per 1000 villages under surveillance. The highest HPAI incidence occurred in Yogyakarta (29.7 per 1,000 villages).59 23 March Japan reports H5N1 in poultry on farms in 2011 Chiba prefecture.

Myanmar reports an additional outbreak of H5N1 in poultry in Shwebo, Sagaing State. 24 March Bangladesh reports 67 outbreaks of H5N1 in 2011 poultry in Barisal, Chittagong, Dhaka, Khulna, Rajshahi, and Shaka districts. th 25 March Indonesia confirms its 175 human case, in a 2-year-old girl from Bekasi 2011 City, West Java province (onset date 2 March). 28 March Republic of Korea reports an additional 2011 outbreak of H5N1 in poultry in Gyeongsangbuk- do. st 29 March Egypt confirms its 131 human case, 2011 in a 32-year old man from Suez governorate (onset date 8 March), its 132nd human case, in a 28-year-old woman from Giza governorate (onset date 8 March) and its 133rd human case, in a 4-year-old boy from Beheira governorate (onset date 5 March). 30 March Viet Nam reports H5N1 in poultry in Binh Dinh, 2011 Hai Phong, Nam Dinh, Nghe An, Quang Ngai, and Quang Tri provinces. 31 March FAO reports that, during February 2010, the 2011 overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 2.5 per 1000 villages under surveillance. The highest HPAI incidence occurred in Yogyakarta (38.8 per 1000 villages). Over the past 12 months, the overall HPAI incidence was 15.7 per 1,000 villages, with the highest incidence in Yogyakarta (232.9 per 1000), followed by Lampung (66.3 per 1000), Bengkulu (47.5 per 1000), and Kepulauan Bangka Belitung (23.9 per 1000).60

FAO reports 9 outbreaks of H5N1 in poultry in Beni Suef, Fayoum, Gharbia, Menofia, and Qena governorates of Egypt between 20 and 28 March 2011.60 th 1 April Indonesia confirms its 176 human case, in a 28-year-old woman from 2011 Gunung Kidul district, Yogyakarta province (onset date 1 March). 45 This timeline is periodically updated. The last update was on: 25 January 2012

th 6 April Egypt confirms its 134 human case, 2011 in a 1-year-old boy from Beheira governorate (onset date 14 February), its 135th human case, in a 3-year-old girl from Beheira governorate (onset date 10 March), its 136th human case, in a 34-year-old woman from Alexandria governorate (onset date 9 March), and its 137th case, in a 30- year-old woman from Kafr el Sheikh governorate (onset date 7 March). There was no epidemiological link between the two cases from Beheira. 7 April FAO reports 8 outbreaks of H5N1 in poultry in Fayoum, Helwan, Menoufiya, Minya, Qena, 2011 Sixth of October and Sohag governorates of Egypt between 28 March and 2 April 2011.61 8 April Japan reports H5N1 in a wild bird in Aichi

2011 prefecture. th 11 April Cambodia confirms its 14 human 2011 case, in an 11-year-old girl from Kampong Cham province (onset date 22 March).

Egypt confirms its 138th human case, in a 20-year-old woman from Beheira governorate (onset date 14 March), its 139th human case, in a 2-year-old girl from Menofia governorate (onset 26 March), its 140th human case in a 55- Israel reports H5N1 in a wild bird in Jehuda & year-old woman from Beheira Samaria. governorate (onset date 20 March), and its 141st human case, in a 1-year- old boy from Fayoum governorate (onset date 20 March).

Bangladesh confirms its 3rd human case, in a 2-year-old boy from Dhaka district (onset date 1 March). This case had no epidemiological link with the previous case reported from Dhaka on 16 March. 14 April FAO reports 9 outbreaks of H5N1 in poultry in Beheira, Damietta, Kafr el Sheikh, Menofia and 2011 Sixth of October governorates of Egypt between 4 and 11 April 2011.62 18 April Viet Nam reports 7 outbreaks of H5N1 in 2011 village poultry in Bac Kan, Dak Lak, Ha Nam, Quang Ngai and Tien Giang provinces.

Republic of Korea reports an additional outbreak of H5N1 in poultry in Gyeongsangbuk- do. 19 April Mongolia reports H5 in wild swans at Zegst 2011 Lake, Sukhbaatar (first report of H5N1 in Mongolia since May 2010) th 21 April Bangladesh reports 31 outbreaks of H5N1 in Cambodia confirms its 15 human 2011 poultry in Barisal, Chittagong, Dhaka, Rajshahi, case, in a 5-year-old girl from Prey and Rangpur districts. Veng province (onset date 11 April).

46 This timeline is periodically updated. The last update was on: 25 January 2012

Viet Nam reports an outbreak of H5N1 in Egypt confirms its 142nd human case, village poultry in Quang Tri province. in a 29-year-old man (onset date 1 April) and its 143rd human case, in a 1 1/2 –year-old boy (onset date 9 April), both from Fayoum governorate. No epidemiological link between these cases was identified. 26 April Viet Nam reports an outbreak of H5N1 in 2011 village poultry in Vinh Long province.

Indonesia reports 18 outbreaks of H5N1 in

village poultry in Gorontalo province. Although Indonesia is considered endemic for H5N1 in poultry, this is the first report of H5N1 in Gorontalo province since June 2007. 5 May FAO reports 10 outbreaks of H5N1 in poultry in Beheira, Beni Suef, Fayoum, Luxor, Menoufiya, 2011 Sharkia and Sohag governorates of Egypt between 14 and 28 April 2011. 63 12 May Bangladesh reports 3 outbreaks of H5N1 in 2011 commercial poultry in Dhaka district.

FAO reports 8 outbreaks of H5N1 in poultry in Dakahlia, Damietta, Fayoum, Menoufiya and Port Said governorates of Egypt between 2 and 7 May 2011. 64 Indonesia confirms its 177th human 13 May Japan reports H5N1 in wild birds in Shimane case, in a 8-year-old girl from DKI 2011 and Tochigi prefectures. Jakarta province (onset date 4 April). 16 May Viet Nam reports 4 outbreaks of H5N1 in 2011 village poultry in Lang Son, Quang Ngai, and Vinh Long provinces. 26 May FAO reports 14 outbreaks of H5N1 in poultry in Beni Suef, Fayoum, Menoufiya, Qaliyoubia and 2011 Sharkia governorates of Egypt between 9 and 22 May 2011. 65 31 May Republic of Korea reports an outbreak of H5N1

2011 in poultry in Gyeonggi-do. th 1 June Egypt confirms its 144 human case, in a 30-year-old woman from 2011 Alexandria governorate (onset date 26 April). th 3 June Indonesia confirms its 178 human 2011 case, in a 1-year-old girl from DKI Jakarta province (onset date 3 April). 7 June Viet Nam reports an additional outbreak of

2011 H5N1 in village poultry in Lang Son province. th 10 June Cambodia confirms its 16 human 2011 case, in a 7-year-old girl from Prey Vang province (onset date 24 May). th 16 June Egypt confirms its 145 human case, 2011 in a 40-year-old woman from Aswan governorate (onset date 14 May), its FAO reports 24 outbreaks of H5N1 in poultry in 146th human case, in a 21-year-old Alexandria, Beheira, Beni Suef, Dakahlia, woman from Menoufiya (onset date Damietta, Fayoum, Gharbia, Giza, Menoufiya, 21 May), its 147th human case, in a Minya, Qaliyoubia and Sharkia governorates of 31-year-old man from Qaliyoubia Egypt between 21 May and 11 June 2011. 66 governorate (onset date 21 May), its 148th human case, in a 32-year-old man from Cairo governorate (onset 47 This timeline is periodically updated. The last update was on: 25 January 2012

date 23 May), and its 149th human case, in a 16-year-old boy from Menoufiya governorate (onset date 21 May). th 22 June Egypt confirms its 150 human case, 2011 in a 27-year-old man from Qena governorate (onset date 5 June). 23 June FAO reports 13 outbreaks of H5N1 in poultry in Dakahlia, Damietta, Giza, Menoufiya and 2011 Qaliyoubia governorates of Egypt between 13 and 18 June 2011. 67 30 June FAO reports 10 outbreaks of H5N1 in poultry in Beheira, Dakahlia, Damietta, Gharbia, Giza and 2011 Qaliyoubia governorates of Egypt between 12 and 24 June 2011. 68 7 July Bangladesh reports 1 outbreak of H5N1 in 2011 commercial poultry in Khulna district.

FAO reports 8 outbreaks of H5N1 in poultry in Damietta, Gharbia, Giza and Qaliyoubia governorates of Egypt between 26 and 30 June 2011.69

FAO reports that the overall HPAI incidence in

Indonesia based on PDSR village-level surveillance was 2.8 per 1000 villages under surveillance during March 2011 and 3.3 per 1000 during April. Over the past 12 months (from April), the overall HPAI incidence was 19.7 per 1000 villages, with the highest incidence in DI Yogyakarta (237.4 per 1000), followed by Lampung (59.1 per 1000), and Sumatera Barat (57.6 per 1000).69 14 July FAO reports 6 outbreaks of H5N1 in poultry in 2011 Fayoum, Giza, Minya and Sharkia governorates of Egypt between 3 and 6 July 2011.70 18 July Viet Nam reports 2 outbreaks of H5N1 in 2011 village poultry in Phu Tho and Quang Tri provinces. 21 July FAO reports 5 outbreaks of H5N1 in poultry in 2011 Beheira, Fayoum, Gharbia, Giza and Sharkia governorates of Egypt between 12 and 17 July 2011.71

FAO reports that the overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 2.2 per 1000 villages under surveillance during May 2011.71 26 July Cambodia reports an outbreak of H5N1 in wild

2011 birds in a zoo in Takeo Province. 28 July FAO reports 6 outbreaks of H5N1 in poultry in Fayoum, Qaliyoubia, Qena and Sharkia 2011 governorates of Egypt between 4 and 21 July 2011.72 29 July Cambodia reports an outbreak of H5N1 in 2011 backyard poultry in Banteay Meanchey province. th 2 August Cambodia confirms its 17 human 2011 case, in a 4-year-old girl from Banteay Meanchey Province (onset 48 This timeline is periodically updated. The last update was on: 25 January 2012

date 11 July). 4 August Vietnam reports 5 outbreaks of H5N1 in village 2011 poultry in Nghe An province.

FAO reports 10 outbreaks of H5N1 in poultry in Fayoum, Menoufiya, Qaliyoubia, Giza and Sharkia governorates of Egypt between 25 and 30 July 2011.73 st 9 August Egypt confirms its 151 human case, 2011 in a 6-year-old girl from Beheira governorate (onset date 12 July). 11 August FAO reports 4 outbreaks of H5N1 in poultry in Fayoum, Qaliyoubia, Sharkia and Gharbia 2011 governorates of Egypt between 1 and 6 August 2011. 74 18 August FAO reports 2 outbreaks of H5N1 in poultry in 2011 Beni Suef and Qaliyoubia governorates of Egypt between 7 and 13 August 2011. 75 th 19 August Cambodia confirms its 18 human case, in a 6-year-old girl from 2011 Kampong Cham Province (onset date 7 August). 25 August FAO reports 1 outbreak of H5N1 in poultry in 2011 Giza governorate of Egypt on the 15 August 2011. 76

FAO reports that the overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 1.0 per 1000 villages under surveillance during June 2011. Over the past 12 months (from June), the overall HPAI incidence was 20.9 per 1000 villages, with the highest incidence in DI Yogyakarta (210.9 per 1 000), followed by Bengkulu (72.9 per 1000), and Sumatera Barat (69.6 per 1000). 76 5 Viet Nam reports 3 outbreaks of H5N1 in September village poultry in Quang Ngai, Quang Tri, and 2011 Thai Binh provinces. 8 Bangladesh reports 4 outbreaks of H5N1 in September commercial poultry in Dhaka, Khulna, and 2011 Rajshahi districts.

India reports an outbreak of H5N1 in backyard poultry in Assam. This is the first report of H5N1 in India since March 2011.

FAO reports 1 outbreak of H5N1 in poultry in a live bird market in Qaliyoubia governorate of Egypt on the 20 August 2011. 77 12 Cambodia reports an additional outbreak of September H5N1 in backyard poultry in Banteay Meanchey 2011 province. 15 FAO reports 2 outbreaks of H5N1 in poultry in small holder farms in Dakahlia and Giza September 2011 governorates of Egypt between 5 and 7 September 2011. 78 19 India reports an outbreak of H5N1 in backyard September poultry in West Bengal. 2011

49 This timeline is periodically updated. The last update was on: 25 January 2012

22 FAO reports an outbreak of H5N1 HPAI in September poultry in a small holder farm in Menoufia 2011 governorate of Egypt on 17 September 2011.79 29 FAO reports that the overall HPAI incidence in September Indonesia based on PDSR village-level 2011 surveillance was 1.6 per 1000 villages under surveillance during July 2011. Over the past 12 months (from July), the overall HPAI incidence was 21.7 per 1000 villages, with the highest

incidence in DI Yogyakarta (207.8 per 1000), followed by Sumatera Barat (70.4 per 1000), and Bengkulu (68.9 per 1000). In August 2011, the overall number of H5N1 HPAI outbreaks reported in villages under PDSR surveillance was 54.80 th 10 Indonesia confirms its 179 human case, in a 1-year-old girl from West October 2011 Jakarta district, DKI Jakarta province (onset date 8 August). 13 Iran reports 2 outbreaks of H5N1 in backyard October poultry in Mazandaran. This is the first report of 2011 H5N1 in Iran since December 2007.

FAO reports that the overall HPAI incidence in Indonesia based on PDSR village-level

surveillance was 0.9 per 1000 villages under surveillance during August 2011. The highest HPAI incidence occurred in Sulawesi Barat (21.7 per 1000) followed by Sulawesi Selatan (5.3 per 1000), and Kepulauan Bangka Belitung (2.6 per 1000). 80,81 24 Iran reports an additional outbreak of H5N1 in October backyard poultry in Mazandaran. 2011 th 26 Indonesia confirms its 180 human October case, in a 5-year-old girl from Bangli district, Bali province (onset date 27 2011 September), and its 181st human case, in her 10-year-old brother (onset date 30 September). 27 FAO reports 4 outbreaks of H5N1 in poultry in a October commercial farm in Beheira, and in backyard 2011 poultry in Fayoum, Gharbia and Giza governorates of Egypt between 18 and 24 October 2011. 82 nd 2 Egypt confirms its 152 human case, in a 1-year-old boy from Gharbia November 2011 governorate (onset date 17 September). 7 Cambodia reports an outbreak of H5N1 in November commercial poultry in Battambang province. 2011 10 Vietnam reports an outbreak of H5N1 in village November birds in Nghe An province. 2011 nd 15 Indonesia confirms its 182 case, in a 29-year-old female from Bangli November 2011 district, Bali province (onset date 10 October, mother of the 2 cases earlier 50 This timeline is periodically updated. The last update was on: 25 January 2012

reported). 17 FAO reports that the overall HPAI incidence in November Indonesia based on PDSR village-level 2011 surveillance was 0.8 per 1000 villages under surveillance during September 2011. The highest HPAI incidence occurred in Bali (5.6 per 1000) followed by Sulawesi Tengah (4.3 per 1000), and Kalimantan Barat (3.1 per 1000). Two outbreaks were reported in two villages in Flores Timur District, Nusa Tenggara Timur Province by the Disease Investigation Centre Denpasar in September 2011. 83 24 FAO reports an outbreak of H5N1 in backyard November poultry in Menia Governorate of Egypt on 16 2011 November. 84 rd 29 Egypt confirms its 153 human case, in a 31-year-old female from November 2011 Dakahlia governorate (onset date 10 November). 2 Nepal reports an outbreak of H5N1 in backyard December poultry in Bagmati zone. This is the first report 2011 of H5N1 in Nepal since October 2010. 8 FAO reports an outbreak of H5N1 in backyard poultry in Menia Governorate of Egypt on 1 December 85 2011 December.

FAO reports that the overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 1.2 per 1000 villages under surveillance during October 2011. The highest HPAI incidence occurred in Bali (25.1 per 1000) followed by Nusa Tenggara Barat (20.6 per 1000), and Gorontalo (4.5 per 1000). Nineteen outbreaks were reported in 19 villages in Lombok Island, Nusa Tenggara Barat Province by Local Disease Control Centres (LDCC) in October 2011. 85 12 China reports an outbreak of H5N1 in village December birds in Tibet. This is the first report of H5N1 in 2011 China since May 2010. th th 15 Egypt confirms its 154 and its 155 December FAO reports an outbreak of H5 in backyard human cases, in a mother and her 2011 poultry in Giza governorate of Egypt, on 4 young child from Dakahlia 86 December. Governorate (onset dates 26 November). 19 China Hong Kong SAR reports H5N1 in a wild December bird on Yuen Long. 2011 21 th December Bangladesh reports 4 outbreaks of H5N1 in Egypt confirms its 156 human case, 2011 commercial poultry in Dhaka and Khulna in a 29-year-old man from Dakahlia districts. Governorate (onset date 8 December).

22 FAO reports 3 outbreaks of H5 in backyard poultry in Dakahlia, Gharbia and Menoufiya December 2011 governorates of Egypt, between 1 and 13 December. 87 China Hong Kong SAR reports H5N1 from a 23 chicken carcass in Cheung Sha Wan and in a 51 This timeline is periodically updated. The last update was on: 25 January 2012

December wild bird in Tin Shui Wai. 2011 29 FAO reports 2 outbreaks of H5 in backyard December poultry in Dakahlia governorate of Egypt, 2011 between 21 and 25 December. 88 st 5 January China confirms its 41 human case, 2012 in a 39-year-old man from Guangdong Province (onset date 21 FAO reports 4 outbreaks of H5 in backyard December 2011). The last case poultry in Damietta, Gharbia, Kafr el Sheikh, confirmed by China had an onset of Qaliyoubia and Menoufiya governorates of November 2010. Egypt, between 25 December 2011 and 2 January 2012. 89 Egypt confirms its 157th human case, in a 42 year-old man from Menoufiya Governorate (onset date 16 December 2011). 06 China Hong Kong SAR reports H5N1 in wild January birds in Tuen Mun and Lantau. 2012 09 Bhutan reports an outbreak of H5N1 in backyard poultry in Chhukha district. This is the January 2012 first report of H5N1 in Bhutan since March 2010. rd 11 Indonesia confirms its 183 human January India reports an outbreak of H5N1 in backyard case, in a 23 year-old man from 2012 poultry in Orissa state. Jakarta Province (onset date 31 December 2011). 12 FAO reports 4 outbreaks of H5 in backyard January poultry in Gharbia and Menoufiya governorates 90 2012 of Egypt between 3 and 9 January.

FAO reports that the overall HPAI incidence in Indonesia based on PDSR village-level surveillance was 0.6 per 1000 villages under surveillance during November 2011. The highest HPAI incidence occurred in Sulawesi Barat (7.8 per 1000) followed by DI Yogyakarta (4.6 per 1000), and Sulawesi Selatan (3.4 per 1000). 90 13 India reports an additional outbreak of H5N1 in January a poultry farm in Meghalaya state. 2012 15 Bangladesh reports 3 outbreaks of H5N1 in January commercial poultry in Dhaka and Khulna 2012 districts. th 16 Cambodia confirms its 19 human case, in a 2 year-old boy from January 2012 Banteay Meanchey Province (onset date 3 January). 17 Bhutan reports an additional outbreak of H5N1 January in backyard poultry in Thimphu district. 2012 18 Bhutan reports an additional outbreak of H5N1 January in backyard poultry in Chhukha district. 2012 India reports and additional outbreak of H5N1 in backyard poultry in Orissa state. 19 FAO reports an outbreak of H5 in backyard Egypt confirms its 158th human case, January poultry in Menia Governorate of Egypt on 6 in a 2 year-old girl from Cairo 52 This timeline is periodically updated. The last update was on: 25 January 2012

2012 January. 91 Governorate (onset date 30 October 2011), and its 159th human case in a 31 year-old man from Fayoum governorate (onset date 1 January).

Indonesia confirms its 184th human case, in a 5 year-old girl from Jakarta Province (identified by a surveillance team on 7 January, she was a family contact of the case previously reported, with onset date 31 December 2011). th 20 Viet Nam confirms its 120 human case, in an 18-year-old man from January China Hong Kong SAR reports additional Kien Giang Province (onset date 10 2012 H5N1 in a wild bird in Yuen Long. January). The last case confirmed by Viet Nam had an onset of April 2010. 24 China confirms its 42nd human case, January in a 39 year-old man from Guizhou 2012 Province (onset date 6 January).

Note: As of 1 April 2006, reports of influenza infection in animals refer to official OIE reports, as available on http://www.oie.int/wahid-prod/public.php?page=weekly_report_index&admin=0, unless otherwise noted.

References

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53 This timeline is periodically updated. The last update was on: 25 January 2012

14. World Health Organization Global Influenza Program Surveillance Network. Emerg Infect Dis 2005; 11: 1515–21. 15. Taubenberger JK et al. Characterization of the 1918 influenza virus polymerase genes. Nature 2005; 437: 889–93. 16. Tumpey TM et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005; 310: 77–80. 17. Yingst S., et al., Qinghai-like H5N1 from Domestic Cats, Northern Iraq. Letter, Emerging Infectious Diseases 2006, 12(8):1295 18. Chen H et al. Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci USA 2006; 103: 2845–2850. 19. Shinya K et al. Influenza virus receptors in the human airway. Nature 2006; 440: 435–36. 20. van Riel D et al. H5N1 virus attachment to lower respiratory tract. ScienceExpress 23 Mar 2006. Published online at: http://www.sciencemag.org/cgi/content/abstract/1125548 21. World Health Organization. Epidemiology of WHO-confirmed human cases of avian influenza A(H5N1) infection.Weekly Epidemiological Record, 2006, 81:249–260 22. Smith et al. Emergence and predominance of an H5N1 influenza variant in China. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16936-41. Epub 2006 Oct 30 23. World Health Organization. Update: WHO-confirmed human cases of avian influenza A(H5N1) infection, 25 November 2003– 24 November 2006.Weekly Epidemiological Record, 2007, 82:41–48. 24. FAOAIDE News. Situation Update 45, 20 Feb 2007. http://www.fao.org/docs/eims/upload//224260/AIDENews_mar07_no45.pdf. 25. Sedyaningsih, E., Isfandari, S., Setiawaty, V., Rifati, L., Harun, S., Purba, W., Imari, S., Giriputra, S., Blair, P., Putnam, S., Uyeki, T., and Soendoro1, T. 2007. Epidemiology of Cases of H5N1 Virus Infection in Indonesia, July 2005–June 2006. Journal of Infectious Diseases 196:522 - 527. 26. FAO AIDE news. Situation Update 48, 15 October, 2007. Available at http://www.fao.org/docs/eims/upload//234638/AIDEnews_oct07_no48_.pdf 27. FAO AIDE news. Situation Update 49, 17 December, 2007. Available at http://www.fao.org/docs/eims/upload//237459/AIDEnews_dec07_no49.pdf 28. FAO AIDE news. Situation Update 50, 11 February, 2008. Available at http://www.fao.org/docs/eims/upload//239862/AIDEnews_feb08_no50.pdf 29. FAO AIDE news. Situation Update 51, 16 March, 2008. Available at http://www.fao.org/docs/eims/upload//239862/AIDEnews_feb08_no50.pdf 30. Gilbert M, Xiao X, Pfeiffer DU, Epprecht M, Boles S, Czarnecki C, Chaitaweesub P, Kalpravidh W, Minh PQ, Otte MJ, Martin V, Slingenbergh J. 2008. Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia. Proc Natl Acad Sci USA. 105(12):4769-74. Epub 2008 Mar 24. Available online at: http://www.pnas.org/cgi/content/full/105/12/4769 31. FAO AIDE news. Situation Update 54, 16 Jun, 2008. Available at http://www.fao.org/avianflu/documents/AIDEnews_june08_no54.pdf 32. FAO AIDE news. Situation Update 55, 25 Jul, 2008. Available at http://www.fao.org/docs/eims/upload//246457/aj097e00.pdf 33. Bulletin on Avian Influenza in Cambodia, Issue 182, 19 Dec 2008. (prepared by UN system in Cambodia with the Royal Government of Cambodia and Development Partners). 34. FAO AIDE news. Situation Update 57, 15 Jan, 2009. Available at ftp://ftp.fao.org/docrep/fao/011/ai325e/ai325e00.pdf 35. Strengthening Avian Influenza Detection and Response (SAIDR) joint website http://www.saidr.org/en/animals.php#170309 36. FAOAIDE News. Situation Update 60, 30 Jun 2009. ftp://ftp.fao.org/docrep/fao/012/ak132e/ak132e00.pdf 37. Strengthening Avian Influenza Detection and Response (SAIDR) joint website http://www.saidr.org/en/animals.php 38. FAO EMPRES H5N1 HPAI Global overview - August 2009, issue 14. Available at : ftp://ftp.fao.org/docrep/fao/012/ak146e/ak146e00.pdf 54 This timeline is periodically updated. The last update was on: 25 January 2012

39. FAO ECTAD HPAI Situation Update No. 403, 29 Oct 2009. 40. FAO ECTAD HPAI Situation Update No. 415, 21 Jan 2010. 41. FAOAIDE News. Situation Update 66, 15 May 2010. http://www.fao.org/docrep/012/ak756e/ak756e00.pdf 42. FAO ECTAD HPAI Situation Update No. 435, 10 Jun 2010. 43. FAO ECTAD HPAI Situation Update No. 438, 1 Jul 2010. 44. FAO ECTAD HPAI Situation Update No. 439, 8 Jul 2010. 45. FAO ECTAD HPAI Situation Update No. 441, 29 Jul 2010. 46. FAO ECTAD HPAI Situation Update No. 444, 19 Aug 2010. 47. FAO ECTAD HPAI Situation Update No. 448, 23 Sep 2010. 48. FAO ECTAD HPAI Situation Update No. 450, 7 Oct 2010. 49. FAO ECTAD HPAI Situation Update No. 452, 21 Oct 2010. 50. FAO ECTAD HPAI Situation Update No. 453, 28 Oct 2010. 51. FAO ECTAD HPAI Situation Update No. 454, 4 Nov 2010. 52. FAO ECTAD HPAI Situation Update No. 456, 18 Nov 2010. 53. www.who.int/csr/disease/avian_influenza/country/cases_table_2010_11_19 54. FAO ECTAD HPAI Situation Update No. 458, 2 Dec 2010. 55. FAO ECTAD HPAI Situation Update No. 459, 9 Dec 2010. 56. FAO ECTAD HPAI Situation Update No. 463, 6 Jan 2011. 57. FAO ECTAD HPAI Situation Update No. 465, 20 Jan 2011 58. FAO Aide News, Situation Update 74, 9 Feb 2011 59. FAO ECTAD HPAI Situation Update No. 473, 17 Mar 2011 60. FAO ECTAD HPAI Situation Update No. 475, 31 Mar 2011 61. FAO ECTAD HPAI Situation Update No. 476, 7 Apr 2011 62. FAO ECTAD HPAI Situation Update No. 477, 14 Apr 2011 63. FAO ECTAD HPAI Situation Update No. 480, 5 May 2011 64. FAO ECTAD HPAI Situation Update No. 481, 12 May 2011 65. FAO ECTAD HPAI Situation Update No. 483, 26 May 2011 66. FAO ECTAD HPAI Situation Update No. 486, 16 June 2011 67. FAO ECTAD HPAI Situation Update No. 487, 23 June 2011 68. FAO ECTAD HPAI Situation Update No. 488, 30 June 2011 69. FAO ECTAD HPAI Situation Update No. 489, 7 July 2011 70. FAO ECTAD HPAI Situation Update No. 490, 14 July 2011 71. FAO ECTAD HPAI Situation Update No. 491, 21 July 2011 72. FAO ECTAD HPAI Situation Update No. 492, 28 July 2011 73. FAO ECTAD HPAI Situation Update No. 493, 04 August 2011 74. FAO ECTAD HPAI Situation Update No. 494, 11 August 2011 75. FAO ECTAD HPAI Situation Update No. 495, 18 August 2011 76. FAO ECTAD HPAI Situation Update No. 496, 25 August 2011 77. FAO ECTAD HPAI Situation Update No. 498, 8 September 2011 78. FAO ECTAD HPAI Situation Update No. 499, 15 September 2011 79. FAO ECTAD HPAI Situation Update No. 500, 22 September 2011 80. FAO ECTAD HPAI Situation Update No. 501, 29 September 2011 81. FAO ECTAD HPAI Situation Update No. 503, 13 October 2011 82. FAO ECTAD HPAI Situation Update No. 505, 27 October 2011 83. FAO ECTAD HPAI Situation Update No. 508, 17 November 2011 84. FAO ECTAD HPAI Situation Update No. 509, 24 November 2011 85. FAO ECTAD HPAI Situation Update No. 511, 8 December 2011 86. FAO ECTAD HPAI Situation Update No. 512, 15 December 2011 87. FAO ECTAD HPAI Situation Update No. 513, 22 December 2011 88. FAO ECTAD HPAI Situation Update No. 514, 29 December 2011 89. FAO ECTAD HPAI Situation Update No. 515, 5 January 2012 90. FAO ECTAD HPAI Situation Update No. 516, 12 January 2012 91. FAO ECTAD HPAI Situation Update No. 517, 19 January 2012

55 This timeline is periodically updated. The last update was on: 25 January 2012