Supplementary Table 2: Gene Ontology of the Differentially Expressed Genes in the DIO and DR Comparison

Supplementary Table 2: Gene Ontology of the differentially expressed genes in the DIO and DR comparison.

DIO compared to DR Function Type Enrichment Score Enrichment p-value transcription biological process 7.38205 0.000622325 cellular biopolymer biological process 6.69259 0.00124007 biosynthetic process biopolymer biosynthetic biological process 6.68595 0.00124833 process neurotransmitter secretion biological process 5.79275 0.00304958 regulation of transcription, biological process 5.61569 0.00364028 DNA-dependent myeloid leukocyte biological process 5.58211 0.0037646 activation response to mechanical biological process 5.22062 0.00540396 stimulus biopolymer metabolic biological process 5.08884 0.00616517 process macromolecule metabolic biological process 4.90404 0.00741654 process regulation of RNA biological process 4.82885 0.00799574 metabolic process regulation of biological process 4.39054 0.012394 macromolecule metabolic process hyperosmotic response biological process 4.28689 0.0137476 macrophage chemotaxis biological process 4.28689 0.0137476 re-entry into mitotic cell biological process 4.28689 0.0137476 cycle myeloid leukocyte biological process 4.28689 0.0137476 mediated immunity neutrophil mediated biological process 4.28689 0.0137476 immunity gut morphogenesis biological process 4.28689 0.0137476 post-embryonic camera- biological process 4.28689 0.0137476 type eye development choline transport biological process 4.28689 0.0137476 locomotor rhythm biological process 4.28689 0.0137476 saliva secretion biological process 4.28689 0.0137476 circadian behavior biological process 4.28689 0.0137476 smooth muscle contraction biological process 4.28689 0.0137476 involved in micturition cell differentiation biological process 4.13079 0.0160701 macrophage activation biological process 4.00148 0.0182886 during immune response epidermal cell biological process 4.00148 0.0182886 differentiation epidermis morphogenesis biological process 4.00148 0.0182886 spermatid differentiation biological process 4.00148 0.0182886 regulation of action biological process 4.00148 0.0182886 potential in neuron regulation of hormone biological process 4.00148 0.0182886 metabolic process relaxation of vascular biological process 4.00148 0.0182886 smooth muscle cytokine-mediated biological process 3.92342 0.0197734 signaling pathway metabolic process biological process 3.88804 0.0204854 response to abiotic biological process 3.81273 0.0220877 stimulus microtubule bundle biological process 3.7806 0.022809 formation retina morphogenesis in biological process 3.7806 0.022809 camera-type eye ethanolamine and biological process 3.7806 0.022809 derivative metabolic process leukocyte mediated biological process 3.7806 0.022809 immunity enteric nervous system biological process 3.7806 0.022809 development mechanosensory behavior biological process 3.7806 0.022809 organic alcohol transport biological process 3.7806 0.022809 cytoplasm organization biological process 3.7806 0.022809 urinary bladder smooth biological process 3.7806 0.022809 muscle contraction urinary tract smooth biological process 3.7806 0.022809 muscle contraction fat cell differentiation biological process 3.73386 0.0239005 muscle contraction biological process 3.69833 0.0247649 muscle system process biological process 3.62943 0.0265314 lens morphogenesis in biological process 3.60055 0.0273088 camera-type eye anti-apoptosis biological process 3.56321 0.0283476 regulation of metabolic biological process 3.46498 0.0312737 process cilium morphogenesis biological process 3.44866 0.0317882 ER overload response biological process 3.44866 0.0317882 UTP biosynthetic process biological process 3.44866 0.0317882 CTP biosynthetic process biological process 3.44866 0.0317882 cell volume homeostasis biological process 3.44866 0.0317882 negative regulation of biological process 3.44866 0.0317882 smooth muscle contraction morphogenesis of an biological process 3.44866 0.0317882 epithelial sheet branching involved in lung biological process 3.44866 0.0317882 morphogenesis in utero embryonic biological process 3.445 0.0319049 development developmental growth biological process 3.43813 0.0321246 cell maturation biological process 3.40828 0.0330982 negative regulation of biological process 3.37842 0.0341012 apoptosis chordate embryonic biological process 3.37842 0.0341012 development cellular developmental biological process 3.36967 0.0344009 process response to stimulus biological process 3.33099 0.0357576 macrophage activation biological process 3.31739 0.0362472 protein export from biological process 3.31739 0.0362472 nucleus oligodendrocyte biological process 3.31739 0.0362472 differentiation GTP biosynthetic process biological process 3.31739 0.0362472 excretion biological process 3.31739 0.0362472 cellular homeostasis biological process 3.31739 0.0362472 negative regulation of biological process 3.31739 0.0362472 muscle contraction negative regulation of biological process 3.31389 0.0363744 programmed cell death embryonic development biological process 3.31389 0.0363744 ending in birth or egg hatching negative regulation of cell biological process 3.29807 0.0369546 death ATP metabolic process biological process 3.20187 0.040686 detection of mechanical biological process 3.20187 0.040686 stimulus involved in sensory perception of sound nucleoside biosynthetic biological process 3.20187 0.040686 process pyrimidine ribonucleoside biological process 3.20187 0.040686 biosynthetic process pyrimidine nucleoside biological process 3.20187 0.040686 biosynthetic process cardiac muscle contraction biological process 3.20187 0.040686 RNA polyadenylation biological process 3.20187 0.040686 anatomical structure biological process 3.11014 0.0445946 morphogenesis synaptogenesis biological process 3.09877 0.0451046 positive regulation of biological process 3.09877 0.0451046 fibroblast proliferation lipid catabolic process biological process 3.03899 0.0478831 nucleobase, nucleoside and biological process 3.00572 0.0495031 nucleotide biosynthetic process reflex biological process 3.00572 0.0495031 RNA 3'-end processing biological process 3.00572 0.0495031

Function Type Enrichment Score Enrichment p-value synapse part cellular component 6.72089 0.00120546 cytosol cellular component 6.1673 0.00209689 apical plasma cellular component 5.74766 0.00319023 membrane plasma membrane part cellular component 5.26321 0.00517868 intracellular cellular component 4.40039 0.0122725 basolateral plasma cellular component 4.22911 0.0145653 membrane intracellular part cellular component 4.02244 0.0179093 proton-transporting cellular component 4.00148 0.0182886 two-sector ATPase complex membrane-bounded cellular component 4.00148 0.0182886 organelle cell-cell junction cellular component 4.00051 0.0183063 synaptic vesicle cellular component 3.8838 0.0205725 proton-transporting V- cellular component 3.7806 0.022809 type ATPase, V1 domain microtubule associated cellular component 3.73386 0.0239005 complex cell part cellular component 3.69484 0.0248514 terminal button cellular component 3.44866 0.0317882 apical junction cellular component 3.31739 0.0362472 complex dendritic shaft cellular component 3.31739 0.0362472 organelle cellular component 3.31739 0.0362472 tight junction cellular component 3.23965 0.0391776 occluding junction cellular component 3.23965 0.0391776 proton-transporting cellular component 3.09877 0.0451046 two-sector ATPase complex, catalytic domain cell junction cellular component 3.04487 0.0476023

Function Type Enrichment Score Enrichment p-value phosphoric diester molecular function 5.61793 0.00363217 hydrolase activity histone-lysine N- molecular function 5.22062 0.00540396 methyltransferase activity nucleobase, nucleoside, molecular function 4.78348 0.00836685 nucleotide kinase activity histone methyltransferase molecular function 4.65817 0.00948377 activity protein methyltransferase molecular function 4.37826 0.0125472 activity symporter activity molecular function 4.32717 0.0132048 cytoskeletal regulatory molecular function 4.28689 0.0137476 protein binding guanylate kinase activity molecular function 4.28689 0.0137476 calmodulin-dependent molecular function 4.28689 0.0137476 cyclic-nucleotide phosphodiesterase activity calcium- and calmodulin- molecular function 4.28689 0.0137476 regulated 3',5'-cyclic-GMP phosphodiesterase activity nucleotide binding molecular function 4.24472 0.0143397 solute:cation symporter molecular function 4.04797 0.0174578 activity phosphodiesterase I activity molecular function 4.00148 0.0182886 chemokine receptor activity molecular function 4.00148 0.0182886 polynucleotide molecular function 4.00148 0.0182886 adenylyltransferase activity ceramidase activity molecular function 3.7806 0.022809 ribonucleotide binding molecular function 3.64539 0.0261112 purine ribonucleotide molecular function 3.64539 0.0261112 binding p53 binding molecular function 3.44866 0.0317882 cation:chloride symporter molecular function 3.44866 0.0317882 activity nucleoside diphosphate molecular function 3.44866 0.0317882 kinase activity ATP binding molecular function 3.43301 0.0322895 adenyl ribonucleotide molecular function 3.42319 0.0326081 binding secondary active molecular function 3.39487 0.0335449 transmembrane transporter activity active transmembrane molecular function 3.39487 0.0335449 transporter activity calcium channel regulator molecular function 3.31739 0.0362472 activity nucleotide diphosphatase molecular function 3.31739 0.0362472 activity glycerophosphodiester molecular function 3.31739 0.0362472 phosphodiesterase activity inorganic anion exchanger molecular function 3.31739 0.0362472 activity transferase activity, molecular function 3.25589 0.0385466 transferring phosphorus- containing groups binding molecular function 3.25428 0.0386087 pyrophosphatase activity molecular function 3.20508 0.0405555 hydrogen ion transporting molecular function 3.20187 0.040686 ATP synthase activity, rotational mechanism amine transmembrane molecular function 3.20187 0.040686 transporter activity hydrolase activity, acting molecular function 3.18288 0.0414659 on acid anhydrides, in phosphorus-containing anhydrides phosphoric ester hydrolase molecular function 3.18267 0.0414747 activity hydrolase activity, acting molecular function 3.16818 0.0420801 on acid anhydrides 3',5'-cyclic-GMP molecular function 3.00572 0.0495031 phosphodiesterase activity