What Psychiatry Left out of the DSM-5
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Treatment, Adherence, and Disability in Bipolar Disorder
Petri Arvilommi Treatment, Adherence, and Disability in Bipolar Disorder ACADEMIC DISSERTATION To be presented with the permission of the Faculty of Medicine, University of Helsinki, for public examination at the HUCH Psychiatry Centre, Christian Sibelius Auditorium, Välskärinkatu 12, on 10th June 2016, at 12 noon. Department of Psychiatry University of Helsinki Helsinki, Finland Helsinki 2016 Supervisors Professor Erkki Isometsä, M.D., Ph.D. Department of Psychiatry, Faculty of Medicine University of Helsinki Helsinki, Finland and Docent Kirsi Suominen, M.D., Ph.D. Department of Mental Health and Substance Abuse, City of Helsinki, Social Services and Health Care Helsinki, Finland Reviewers Professor Jyrki Korkeila, M.D., Ph.D. Faculty of Medicine, University of Turku, Turku, Finland and Associate professor Olli Kampman, M.D., Ph.D. School of Medicine, University of Tampere Seinäjoki Hospital District, Department of Psychiatry Tampere, Finland Opponent Professor Esa Leinonen, M.D., Ph.D. School of Medicine, University of Tampere Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis ISBN 978-951-51-2205-6 (pbk.) ISBN 978-951-51-2206-3 (PDF) ISSN 2342-3161 (print) ISSN 2342-317X (online) http://ethesis.helsinki.fi T a m p e r e , F i n l a n d “The endless questioning finally ended. My psychiatrist looked at me, there was no uncertainty in his voice. “Manic-depressive illness.” I admired his bluntness. I wished him locusts on his lands and a pox upon his house. Silent, unbelievable rage. I smiled pleasantly. He smiled back. The war had just begun.” Kay Redfield Jamison “An Unquiet Mind” (1995) Abstract Petri Arvilommi. -
Bipolar Disorder
Bipolar Disorder D E P A R T M E N T O F H E A L T H A N D H U M A N S E R V I C E S P U B L I C H E A L T H S E R V I C E N A T I O N A L I N S T I T U T E S O F H E A L T H National Institute of Mental Health ipolar disorder, also known as manic- depressive illness, is a brain disorder that causes unusual shifts in a person�s mood, energy, and ability to function. Different from the normal ups and downs that everyone goes through, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and even suicide. But there is good news: bipolar disorder can be treated, and people with this illness can lead full and productive lives. More than 2 million American adults,1 or about 1 percent of the population age 18 and older in any given year,2 have bipolar disorder. Bipolar disorder typically develops in late adolescence or early adulthood. However, some people have their first symptoms during childhood, and some develop them late in life. It is often not recognized as an illness, and people may suffer for years before it is properly diagnosed and treated. Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person�s life. -
‗DEFINED NOT by TIME, but by MOOD': FIRST-PERSON NARRATIVES of BIPOLAR DISORDER by CHRISTINE ANDREA MUERI Submitted in Parti
‗DEFINED NOT BY TIME, BUT BY MOOD‘: FIRST-PERSON NARRATIVES OF BIPOLAR DISORDER by CHRISTINE ANDREA MUERI Submitted in partial fulfillment of the requirements For the degree of Doctor of Philosophy Dissertation Adviser: Dr. Kimberly Emmons Department of English CASE WESTERN RESERVE UNIVERSITY August 2011 2 CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the thesis/dissertation of Christine Andrea Mueri candidate for the Doctor of Philosophy degree *. (signed) Kimberly K. Emmons (chair of the committee) Kurt Koenigsberger Todd Oakley Jonathan Sadowsky May 20, 2011 *We also certify that written approval has been obtained for any proprietary material contained therein. 3 I dedicate this dissertation to Isabelle, Genevieve, and Little Man for their encouragement, unconditional love, and constant companionship, without which none of this would have been achieved. To Angie, Levi, and my parents: some small piece of this belongs to you as well. 4 Table of Contents Dedication 3 List of tables 5 List of figures 6 Acknowledgements 7 Abstract 8 Chapter 1: Introduction 9 Chapter 2: The Bipolar Story 28 Chapter 3: The Lay of the Bipolar Land 64 Chapter 4: Containing the Chaos 103 Chapter 5: Incorporating Order 136 Chapter 6: Conclusion 173 Appendix 1 191 Works Cited 194 5 List of Tables 1. Diagnostic Criteria for Manic and Depressive Episodes 28 2. Therapeutic Approaches for Treating Bipolar Disorder 30 3. List of chapters from table of contents 134 6 List of Figures 1. Bipolar narratives published by year, 2000-2010 20 2. Graph from Gene Leboy, Bipolar Expeditions 132 7 Acknowledgements I gratefully acknowledge my advisor, Kimberly Emmons, for her ongoing guidance and infinite patience. -
The Syndrome of Karl Ludwig Kahlbaum
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.49.9.991 on 1 September 1986. Downloaded from Journal of Neurology, Neurosurgery, and Psychiatry 1986;49:991-996 The syndrome of Karl Ludwig Kahlbaum MP BARNES, M SAUNDERS, TJ WALLS, I SAUNDERS, CA KIRK From the Department of Neurology, Middlesbrough General Hospital, Middlesbrough, UK SUMMARY Karl Ludwig Kahlbaum was the first to describe catatonia in 1868. There has been a tendency to consider catatonia as a psychiatric disease despite many case reports demonstrating a wide range of medical and neurological as well as psychiatric causes. We present our accumulated experience of the catatonic syndrome. Most cases (36%) were associated with affective illness but five cases (20%) had a defined organic disorder. A significant minority had no identifiable cause and there was only one case of schizophrenia. The idiopathic and affective groups had a high incidence of recurrent catatonic episodes and many had a family history of a similar problem. The prognosis was excellent, except for the few patients who presented with the acute and rapidly progressive form of the syndrome which led to acute renal failure. Karl Ludwig Kahlbaum first described catatonia Case reports during a lecture in Innsbruck in 1868 and published his work on the subject 6 years later in a small A total of 25 cases of catatonia have been seen by the Protected by copyright. monograph entitled "Die Katatonie oder das Department of Neurology at Middlesbrough General Hos- that catatonia is pital during the period 1972 to 1984. The series may under- Spannungsirresein".'1 2 He stressed represent cases with a psychiatric cause although we believe strongly associated with affective illness, both depres- that most instances of catatonia have been referred to the sion and mania. -
FROM MELANCHOLIA to DEPRESSION a HISTORY of DIAGNOSIS and TREATMENT Thomas A
1 FROM MELANCHOLIA TO DEPRESSION A HISTORY OF DIAGNOSIS AND TREATMENT Thomas A. Ban International Network for the History of Neuropsychopharmacology 2014 2 From Melancholia to Depression A History of Diagnosis and Treatment1 TABLE OF CONTENTS Introduction 2 Diagnosis and classifications of melancholia and depression 7 From Galen to Robert Burton 7 From Boissier de Sauvages to Karl Kahlbaum 8 From Emil Kraepelin to Karl Leonhard 12 From Adolf Meyer to the DSM-IV 17 Treatment of melancholia and depression 20 From opium to chlorpromazine 21 Monoamine Oxidase Inhibitors 22 Monoamine Re-uptake Inhibitors 24 Antidepressants in clinical use 26 Clinical psychopharmacology of antidepressants 30 Composite Diagnostic Evaluation of Depressive Disorders 32 The CODE System 32 CODE –DD 33 Genetics, neuropsychopharmacology and CODE-DD 36 Conclusions 37 References 37 INTRODUCTION Descriptions of what we now call melancholia or depression can be found in many ancient documents including The Old Testament, The Book of Job, and Homer's Iliad, but there is virtually 1 The text of this E-Book was prepared in 2002 for a presentation in Mexico City. The manuscript was not updated. 3 no reliable information on the frequency of “melancholia” until the mid-20th century (Kaplan and Saddock 1988). Between 1938 and 1955 several reports indicated that the prevalence of depression in the general population was below 1%. Comparing these figures, as shown in table 1, with figures in the 1960s and ‘70s reveals that even the lowest figures in the psychopharmacological era (from the 1960s) are 7 to 10 times greater than the highest figures before the introduction of antidepressant drugs (Silverman 1968). -
Kay Redfield Jamison
The Rhoda and Bernard Sarnat International Prize in Mental Health 2015 Honoree Kay Redfield Jamison, PhD Dalio Family Professor in Mood Disorders and Professor of Psychiatry, Johns Hopkins University School of Medicine Co-Director, Johns Hopkins Mood Disorders Center The 2015 Rhoda and Bernard Sarnat International Prize in Mental Health is awarded to Kay Jamison for her profound insights into affective disorders and suicide that have not only advanced the field, but also transformed public understanding. Her work combines cutting-edge research with deeply humanistic and often personal narratives—an approach that has cut through stigma to become a cornerstone of the field and a beacon for sufferers of mood disorders. Dr. Jamison is the co-author of Manic-Depressive Illness, the standard medical textbook in the field, and has written more than 125 scientific and clinical articles about mood disorders, suicide, creativity, and lithium. However, her greatest impact may lie in her works of narrative nonfiction, which probe links between creativity and mental illness, trace the natural history of affective disorders, and explore the suicidal mind. An Unquiet Mind: A Memoir of Moods and Madness, which chronicles Dr. Jamison’s own experience with manic-depressive illness, marked a major milestone in combating stigma in the psychiatric profession. It remained on the New York Times best-seller list for 5 months and has been translated into 25 languages. Johns Hopkins Hospital, where Dr. Jamison co-directs the Mood Disorders Center, praises the book on its website as a kind of “bibliotherapy” that does “what pills can’t: It lets patients read for themselves how destructive not taking their medicine can be, it tells of the healing power of structure, psychotherapy and a social network. -
Collated Document Thomas A. Ban
1 THOMAS A. BAN: THE WERNICKE-KLEIST-LEONHARD TRADITION WITH SPECIAL REFERENCE TO MANIA, MELANCHOLIA AND MANIC-DEPRESSIVE PSYCHOSIS Collated Document Thomas A. Ban This document includes Thomas A. Ban’s five essays on the Wernicke-Kleist-Leonhard tradition with special reference to mania, melancholia and manic-depressive psychosis. It also includes Ernst Franzek’s comment and Ban’s reply to the last essay. The document is now open for a final comment to all INHN members. Thomas A. Ban August 6, 2015 Fundamentals of the Wernicke-Kleist-Leonhard tradition Thomas A. Ban October 22, 2015 Carl Wernicke’s classification of psychoses with special reference to mania, melancholia and manic-depressive psychosis Thomas A. Ban November 12, 2015 Karl Kleist and the deconstruction of Kraepelin’s diagnostic concept of manic- depressive psychosis Thomas A. Ban November 26, 2015 Karl Leonhard and the diagnostic re-evaluation of Emil Kraepelin’s diagnostic concept of manic- depressive psychosis Thomas A. Ban December 3, 2015 Psychopathology, Leonhard’s classification and the deconstruction of Kraepelin’s diagnostic concept of manic-depressive psychosis 2 Ernst Franzek February 18, 2016 Comment on Ban’s Psychopathology, Leonhard’s classification and the deconstruction of Kraepelin’s diagnostic concept of manic- depressive psychosis Thomas A. Ban August 6, 2015 Reply to Franzek’s comment Fundamentals of the Wernicke-Kleist-Leonhard Tradition Thomas A Ban In 1956, Fritz Freyhan, a German born American pioneer of neuropsychopharmacology focused attention on the heterogeneity in responsiveness to neuroleptics in patients with the diagnosis of schizophrenia and called for a pharmacological re-evaluation of Kraepelin’s diagnostic concepts (Bleuler 1911; Freyhan 1956; Kraepelin 1899). -
The Kraepelinian Dichotomy – Going, Going . . . but Still Not Gone Nick Craddock and Michael J
The British Journal of Psychiatry (2010) 196, 92–95. doi: 10.1192/bjp.bp.109.073429 Reappraisal The Kraepelinian dichotomy – going, going . but still not gone Nick Craddock and Michael J. Owen Summary Recent genetic studies reinforce the view that current psychiatry will need to move from using traditional approaches to the diagnosis and classification of major descriptive diagnoses to clinical entities (categories and/or psychiatric illness are inadequate. These findings challenge dimensions) that relate more closely to the underlying the distinction between schizophrenia and bipolar disorder, workings of the brain. and suggest that more attention should be given to the relationship between the functional psychoses and neurodevelopmental disorders such as autism. We are Declaration of interest entering a transitional period of several years during which None. The Kraepelinian dichotomy – the broad division of major mood risk gene for schizophrenia,4 and CACNA1C,5 which was strongly and psychotic illness of adulthood into schizophrenia and ‘manic– implicated initially in GWAS of bipolar disorder.6 It is of interest depressive’ (bipolar) illness – has been enshrined in Western that there is evidence that variation at CACNA1C also influences psychiatry for over a century and continues to influence clinical risk of recurrent unipolar depression.5 More broadly, there is practice, research and public perceptions of mental illness. Nearly evidence for overlap in the identity of genes showing gene-wide 5 years ago, we published an editorial1 in which we summarised association signals in GWAS of schizophrenia and bipolar emerging evidence undermining the dichotomy, and argued that disorder.7 Perhaps most compellingly, there is strong evidence that continued adherence to this approach is hampering research and the aggregate polygenic contribution of many alleles of small effect clinical care. -
EPILEPSY and Eegs in BOSTON, BEGINNING at BOSTON CITY HOSPITAL
EPILEPSY AND EEGs IN BOSTON, BEGINNING AT BOSTON CITY HOSPITAL Frank W. Drislane, MD Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA Early Neurology at Harvard Medical School: In the 1920s and 1930s: Neurology and Psychiatry were largely one field. “All practitioners of the specialty [Neurology] were neuropsychiatrists” -- Merritt: History of Neurology (1975) 1923: David Edsall, first full-time Dean at Harvard Medical School “creates a Department of Neurology to build on the fame of James Jackson Putnam” [1] 1928: Harvard, Penn, and Montefiore-Columbia were the only Neurology departments in the US. 1930: The Harvard Medical School Neurology service at Boston City Hospital, one of the first training centers in the US, founded by Stanley Cobb 1935: American Board of Psychiatry and Neurology 1936: “There were only 16 hospitals listed in the United States a having approved training for residency in Neurology.” [1] 1947: There are 32 Neurology residency positions in the US 1948: Founding of the American Academy of Neurology Stanley Cobb (1887 – 1968) 1887: Brahmin, born in Boston. Speech impediment. 1914: Harvard Medical School grad, after Harvard College Studied Physiology at Hopkins 1919: Physiology research with Walter B Cannon and Alexander Forbes at Harvard 1925: Appointed Bullard Professor of Neuropathology at Harvard Medical School {Successors: Raymond Adams, E Pierson Richardson, Joseph Martin} Interested in Neurology and Psychiatry, and particularly, epilepsy and its relation to cerebral blood flow 1925: Starts the Neurology program at Boston City Hospital (with financial support from Abraham Flexner) Faculty include: Harold Wolff (headaches; cerebral circulation; founder of Cornell Neurology Department), Paul Yakovlev, Sam Epstein Cobb’s Neuropathology group at the HMS medical school campus includes William Lennox 1928: Cobb hires Tracy Putnam for a research position in the Neurosurgery division; Houston Merritt arrives as a resident © 2017 The American Academy of Neurology Institute. -
Bipolar Disorders 100 Years After Manic-Depressive Insanity
Bipolar Disorders 100 years after manic-depressive insanity Edited by Andreas Marneros Martin-Luther-University Halle-Wittenberg, Halle, Germany and Jules Angst University Zürich, Zürich, Switzerland KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: 0-306-47521-9 Print ISBN: 0-7923-6588-7 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©2000 Kluwer Academic Publishers Dordrecht All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: http://kluweronline.com and Kluwer's eBookstore at: http://ebooks.kluweronline.com Contents List of contributors ix Acknowledgements xiii Preface xv 1 Bipolar disorders: roots and evolution Andreas Marneros and Jules Angst 1 2 The soft bipolar spectrum: footnotes to Kraepelin on the interface of hypomania, temperament and depression Hagop S. Akiskal and Olavo Pinto 37 3 The mixed bipolar disorders Susan L. McElroy, Marlene P. Freeman and Hagop S. Akiskal 63 4 Rapid-cycling bipolar disorder Joseph R. Calabrese, Daniel J. Rapport, Robert L. Findling, Melvin D. Shelton and Susan E. Kimmel 89 5 Bipolar schizoaffective disorders Andreas Marneros, Arno Deister and Anke Rohde 111 6 Bipolar disorders during pregnancy, post partum and in menopause Anke Rohde and Andreas Marneros 127 7 Adolescent-onset bipolar illness Stan Kutcher 139 8 Bipolar disorder in old age Kenneth I. Shulman and Nathan Herrmann 153 9 Temperament and personality types in bipolar patients: a historical review Jules Angst 175 viii Contents 10 Interactional styles in bipolar disorder Christoph Mundt, Klaus T. -
Patient with Major Endogenous Depressive Episode with Suicide Attempt
Original Article International Journal of Research - GRANTHAALAYAH ISSN (Online): 2350-0530 May 2021 9(5), 137–144 ISSN (Print): 2394-3629 PATIENT WITH MAJOR ENDOGENOUS DEPRESSIVE EPISODE WITH SUICIDE ATTEMPT 1 1 1 2 3 Mariana Andrut, a Voicu , Adriana Mavlea , Ilinca Vlaicu , Florin Mititelu and Simona Trifu 1Faculty of Psychology and Educational Science, University of Bucharest, Romania 2Alex Obregia” Clinical Hospital for Psychiatry, Bucharest, Romania 3”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania ABSTRACT Motivation: Suicide is a major psychiatric emergency, men being more inclined to successful suicide, not to attempts and to approach it by abrupt and aggressive means. Objectives: To present a male patient who developed a major depressive episode, in which the reactive component had a signiicant contribution in return for endogeny. The suicide attempt quickly escalated changes in thymic function over several days. Results: The patient corresponds to the age at which major depressive dis- order begins. There remains a clinical discussion between a genuine suicide Received 28 April 2021 attempt, carried out with a plan, internal turmoil, rumination or a parasuicide, Accepted 18 May 2021 in which the person in question needed a change in the ield of consciousness Published 31 May 2021 to try to throw himself in front of the subway. Note the high internal tension, Corresponding Author the absence of the search for alternative solutions, the narcissistic wound, the Simona Trifu, simona.trifu@umfcd .ro endo-psychic vulnerability, the elements of correctness such as structural men- tal rigidity. DOI 10.29121/ granthaalayah.v9.i5.2021.3925 Conclusions: Early responsiveness to medication emphasizes the endoge- Funding: This research received nous potential and the potential of vulnerability, after the approach through no speciic grant from any funding a combination of antidepressants and antipsychotics, the latter developing a agency in the public, commercial, clearer perspective on reality and decisions. -
Journal Book 1 to Last.Cdr
www.odishajp.com The Odisha Journal of Psychiatry - 2016 Editorial CONCEPTUAL ISSUES IN MOOD DISORDER: AN UPDATE Dr. Amrit Pattojoshi1; Dr. Sandip Motichand Abstract Introduction The concept of mood disorders dates back to Disorders of mood are one the most devastating eternity. This long history of the emotions and their illnesses in psychiatry. They often lead to disability and disorders has a fascinating journey. As with any history significant functional impairment with considerable concerned with disease concepts,the conceptual consequences on the quality of life.[1,2] The concept of history of mood disorders must be scrutinised through affective disorder and mania dates back to the antiquity. close attention to nosological texts in tracing how For example, more than 3,000 years ago, Jewish categories were created how they evolved over the writings reported extreme mood swings in King Saul, time. This article covers the evolution of the concept of consistent with a bipolar illness.[3] The very first word mood disorders and its journey from the Hippocratic of Homer's most celebrated epic, The Iliad, is mania, era to the Kraepelin's dichotomization between where it is used to describe the uncontrollable rage of dementia praecox (schizophrenia) and manic- Achilles against Agammemnon. Descriptions of both depressive insanity (bipolar and unipolar disorders) mania and depression also appear elsewhere in the epic, and its culmination into the contemporary for example in the description of 'Bellerophontes' classifications of mood disorders. It also addresses the depression and of Ajax's condition that resembles problem of boundaries between the different mood psychotic mania and great sadness ending to disorders in terms of their conceptualisation and suicide.[4] The medical compendia of ancient India classification.