Dr. Irshad Hussain
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Dr. Irshad Hussain PhD Chemistry (Nanotechnology) Senior Scientist & Group Leader – Nanobiotech Group, Biotech Interdisciplinary Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), P.O. Box 577, Jhang Road, Faisalabad, Pakistan. Tel: 0092-(0)41-2651475-9, 041-2553519, Cell: 0092-(0)3016042336 Fax: 0092-(0)412651472, Email: [email protected], [email protected] PERSONAL DATA Date of Birth: 10th October, 1967 Place of Birth: Jhang, Pakistan Nationality: Pakistani Marital Status: Married EDUCATION PhD Chemistry (November 10, 2005), Supervisors: Professor Andrew I. Cooper and Professor Mathias Brust, Centre for Nanoscale Science, Department of Chemistry, The University of Liverpool., UK. Thesis Title: “Synthesis of metal nanoparticles and their applications in advanced materials fabrication”. M.Sc. 1st Division 1993, Organic Chemistry, Quaid-e-Azam University, Islamabad, Pakistan. B.Sc. Ist Division 1990, Chemistry, Zoology & Botany, Bahauddin Zakariya University, Multan, Pakistan. SCHOLARSHIPS/MERITS 1: I was awarded a competitive scholarship by Ministry of Science and Technology, Govt. of Pakistan for PhD studies in Germany in 1994 on the basis of my academic record and GRE (Chemistry score = 710). I completed German language course at NIML, but finally couldn’t avail this scholarship due to a change in the policy of Government. 2: Again, I was awarded scholarship by Ministry of Science and Technology, Govt. of Pakistan, under TROSS scholarship scheme for PhD studies in UK in 2001on the basis of my academic record and GRE (Chemistry score of 750). ACADEMIC AND RESEARCH EXPERIENCE 1 1: I completed my PhD studies in 2005 entitled “Synthesis of metal nanoparticles and their applications in advanced materials fabrication” under the supervision of Professor Andrew I. Cooper and Dr Mathias Brust at department of chemistry, The University of Liverpool, UK. During PhD research, we have developed novel protocols for the synthesis of gold, silver, platinum, palladium and ruthenium nanoparticles (A part of it has been published in Langmuir, rest is pending). These metal nanoparticles have further been used to fabricate advanced materials i.e., emulsion templated gold, palladium, platinum and Cr2O3 beads (A part of it has been published in “Advanced Materials” with front cover picture). We have also developed a simple technique to prepare hierarchically porous metal nanoparticles-silica/titania/zirconia composite materials which may be useful heterogeneous catalysts. This simple technique is easy to upscale and quite versatile i.e., can be used to prepare composites of any metal nanoparticles with any inorganic oxide with a good control on the loading and size of the nanoparticles while retaining the hierarchical porous structure of composite materials. We have also used high throughput screening approach for the discovery of novel nanostructures. Using this approach we have developed novel self-assembly techniques to get ordered 1D (nanowires) and 3D (spherical aggregates) assemblies of gold nanoparticles with interesting optical properties which might have potential applications in electronics. In collaboration with a German group, we are measuring the conductivity of 1D gold nanoparticle assemblies (gold nanochains) and upscale this method to produce gold nanowires in bulk. Recently, we have also developed a freezing based technique which can be used to prepare 2D and 3D micro/nanostructures using polymer/inorganic oxides/metal nanoparticles as building blocks. Since it doesn’t involve any chemical process, it is easy to upscale and can be used to prepare a variety of nanomaterials and biomaterials with several applications in bio-sensing and tissue engineering (published in Nature Materials). We have developed another simple technique (emulsions directed) to assemble metal nanoparticles into mesoporous nanomaterials which might have potential applications to be used as nanoporous membranes. Recently we have made a remarkable development in size-controlled synthesis of near-monodisperse gold nanoparticles in the 1-4 nm regime using polymeric stabilizers. This development is expected to be a landmark in nanotechnology, as most of the envisioned applications of nanotechnology in electronic and other industries are entirely dependent on these monodisperse building blocks in this size regime which were difficult to control before. This work has been published in the Journal of the American Chemical Society (JACS) and Langmuir. During my PhD work at Liverpool, we have also developed useful collaboration with various research groups within/outside Liverpool, which have been highly successful leading to a couple of useful collaborative publications. For example, while collaborating with a group in department of biosciences, the University of Liverpool, we have designed peptides having special amino acid sequences which can be used to coat gold nanoparticles making them quite robust for various protein recognition applications (published in JACS). In collaboration with a Dr Christina Roth in Germany, we explored the use of platinum nanoparticles and their alloys and published one article in Chemical Communications and another in Journal of Electroanalytical Chemistry on the use of Fullerene-linked Pt nanoparticle assemblies for electrochemical oxidation of methanol 2 for fuel cell applications. In collaboration with a research group at Lehigh University, USA, we have already published some basic studies on the sintering of gold nanoparticles (Microscopy and Microanalysis). 2: I was selected in PAEC for 6 months postgraduate computer training course at Computer Training Centre (CTC), Islamabad, in 1996 and joined NIBGE in January 1997 as a scientific officer after the completion of this course. In 2001, I was promoted to senior scientific officer and meanwhile awarded scholarship to proceed for PhD at the University of Liverpool, UK. During my stay at NIBGE, I have been working on several national and international projects to work out biotechnological solutions of environmental pollution especially to develop wastewater treatment plants for industrial (textile, pharmaceutical and tannery) effluents and published several national/international articles. I have also been involved in monitoring airborne particulate matter and development of mutagenicity/genotoxicity assays to evaluate air/water quality before and after treatment. 3: Before joining NIBGE in 1997, I have been teaching as a lecturer in chemistry at a Punjab govt. college during 1995-1996. From 1994-1995, I have also worked as a research fellow at HEJ research institute of chemistry, Karachi, Pakistan on biotransformations. During my MSc studies I have worked on the development of a new protocol for the synthesis of Peniolactol (a coumarine) in an organic synthesis group at Quaid-i-Azam University, Islamabad. NANOBIOTECHNOLOGY PROJECT AT NIBGE Based on my progress and achievements in the field of nanotechnology, a PC-1 (worth Rs. 155 million = 2.6 million USD) has been awarded by Ministry of Science and Technology (MoST), Govt. of Pakistan to initiate a nanobiotechnological research at NIBGE, especially to explore the applications of nanotechnology in health, agriculture, environment, catalysis and advanced materials fabrication. The work is in progress and we have already developed international collaboration with famous research groups in UK, USA and Germany. I am Principal Investigator/Project Director of this project. IMPACT FACTOR AND CITATION Impact factor of my published/accepted articles so far is ~ 79.5. The total ISI citation of my articles so far is more than 180. RESEARCH PUBLICATIONS 3 1: Antonios G. Kanaras, Zhenxin Wang, Irshad Hussain, Mathias Brust, Richard Cosstick, and Andrew D. Bates. “Site-specific Ligation of DNA-Modified Gold Nanoparticles Activated by the Restriction Enzyme StyI”. Small, 2007, 1, 67. 2: Zhenxin Wang, Bien Tan, Irshad Hussain, Nicholas Schaeffer, Mark Wyatt, Mathias Brust and Andrew I. Cooper. “Design of Polymeric Stabilizers for Size-Controlled Synthesis of Mono-disperse Gold Nanoparticles in Water”. Langmuir, 2007, 2, 885. 3: Irshad Hussain, Zhenxin Wang, Andrew I. Cooper and Mathias Brust. Formation of spherical nanostructures by controlled aggregation of gold colloids. Langmuir, 2006, 22, 2941. 4: Haifei Zhang, Irshad Hussain, Mathias Brust, and Andrew I. Cooper. “Synthesis of hierarchically porous inorganic–metal site-isolated nanocomposites”. Chemical Communications, 2006, 24, 2539. 5: Haifei Zhang, Irshad Hussain, Mathias Brust, Micheal F. Butler, Steven P. Rannard and Andrew I. Cooper. “Aligned two and three-dimensional structures by directional freezing of polymers and nanoparticles”. Nature Materials, 2005, 4, 787. 6: Christina Roth, Adam J. Papworth, Irshad Hussain, Richard J. Nichols and David J. Schiffrin. “A new Pt-Ru model system to study the bifunctional mechanism of electrocatalysis”. Journal of Electro-analytical Chemistry, 2005, 581, 79. 7: Irshad Hussain, Susan Graham, Zhenxin Wang, Bien Tan, Steven P. Rannard, David C. Sherrington, Andrew I. Cooper and Mathias Brust. “Size-controlled synthesis of near- monodisperse gold nanoparticles in the 1-4 nm range using polymeric stabilizers”. Journal of the American Chemical Society, 2005, 127, 16398. 8: C. J. Kiely, M. Watanabe, A. Burrows, P. Clasen, M. P. Harmer, B. Rodríguez- González, L. Liz-Marzán, I. Hussain, J. Fink and M. Brust. “What are the limitations in the characterization of self-assembled metamaterials using advanced microscopy techniques?”.