TGIF1 Antibody Cat. No.: 56-207

TGIF1 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken

This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 145-174 amino acids from the Central region of human TGIF1.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 43 kDa WEIGHT:

Properties

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by PURIFICATION: dialysis

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

October 1, 2021 1 https://www.prosci-inc.com/tgif1-antibody-56-207.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: TGIF1

ALTERNATE NAMES: TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF

ACCESSION NO.: Q15583

PROTEIN GI NO.: 215274200

GENE ID: 7050

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR BACKGROUND: alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.

REFERENCES: 1) Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)

2) Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)

3) Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :

4) Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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