TGIF1 Antibody Cat. No.: 56-207
TGIF1 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken
This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 145-174 amino acids from the Central region of human TGIF1.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 43 kDa WEIGHT:
Properties
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by PURIFICATION: dialysis
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
October 1, 2021 1 https://www.prosci-inc.com/tgif1-antibody-56-207.html PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: TGIF1
ALTERNATE NAMES: Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
ACCESSION NO.: Q15583
PROTEIN GI NO.: 215274200
GENE ID: 7050
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR BACKGROUND: alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
REFERENCES: 1) Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)
2) Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)
3) Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
4) Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)
ANTIBODIES FOR RESEARCH USE ONLY.
For additional information, visit ProSci's Terms & Conditions Page.
October 1, 2021 2 https://www.prosci-inc.com/tgif1-antibody-56-207.html