Anti-CLSTN1 (Aa 15-42) Polyclonal Antibody (DPABH-01879) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CLSTN1 (aa 15-42) polyclonal antibody (DPABH-01879) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.

Immunogen Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 15-42 of Human CLSTN1 (NP_001009566.1).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 400 μl

Buffer Constituent: 99% PBS

Preservative 0.09% Sodium Azide

Storage Store at 4°C or at -20°C for long term storage.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol CLSTN1

Synonyms CLSTN1; calsyntenin 1; calsyntenin-1; cadherin related family member 12; CDHR12; CSTN1; KIAA0911; alcadein-alpha; alcadein alpha 1; non-classical cadherin XB31alpha; cadherin-related family member 12; non-classical cadherin XB31alpha1; alzheimer-related cadherin-like protein; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2; FLJ32258;

Entrez Gene ID 22883

Protein Refseq NP_001009566

UniProt ID O94985

Chromosome Location 1p36.22

Function calcium ion binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]