NYSCF Conference Overview The NYSCF Conference is unique: it focuses on translational stem THE NEW YORK research, demonstrating the potential to advance cures for the CELL FOUNDATION major diseases of our time. It is designed for all professionals with an interest in stem cell research, including physicians, researchers, clinical investigators, professors, F government and health officials, postdoctoral fellows and graduate students. The panels on Tuesday are designed to reach a broader FIFTH ANNUAL audience, including the lay public. TRANSLATIONAL STEM CELL Conference Location The Rockefeller University, Caspary Auditorium RESEARCH CONFERENCE 1230 York Avenue, at 66th Street, New York, NY

Registration Information: Full Conference C Early registration is recommended as space is limited. Full conference registration includes the Tuesday panels and the Wednesday conference sessions. Individuals wishing to attend only Tuesday’s panels may register for those separately (see below).

To Register please visit www.nyscf.org/conference S Lee Goldman, MD, MPh, Columbia University Medical Center Antonio M. Gotto, Jr., MD, DPhil, Weill Cornell Medical College Early registration: $475, on and prior to September 12, 2010. Douglas A. Melton, PhD, Harvard University Registration: $635 as of September 13, 2010. Paul Nurse, PhD, The Rockefeller University Allen M. Spiegel, MD, Albert Einstein College of Medicine Early registration: $245, on and prior to September 12, 2010. Registration: $325 as of September 13, 2010.

Y Zach W. Hall, PhD, The New York Stem Cell Foundation Fee: $175, with no increase. Proof of identification is required. Ihor Lemischka, PhD, Mount Sinai School of Medicine Dan R. Littman, MD, PhD, Skirball Institute of Biomedicine Fee: $35, with no increase. Proof of identification is required Registration Information: Tuesday Panels Only Robertson Foundation $120 to attend both Tuesday panels (free with full conference registration) Road to the Clinic – 1:15 pm Albert Einstein College of Medicine Regulatory Roadblocks – 4:00 pm N Columbia University Medical Center Early registration is recommended, as space is limited.

Helen and Martin Kimmel Center for Stem Cell Biology, Call For Abstracts New York University School of Medicine The NYSCF Conference poster session is open to all scientists The Mount Sinai School of Medicine working in stem cell and translational research fields. This is Tri-Institutional Stem Cell Initiative: a great opportunity to showcase your research to an international audience of leading researchers and clinicians. Memorial Sloan-Kettering Center, The Rockefeller Abstracts must be submitted electronically to [email protected] University, Weill Cornell Medical College by 5:00 pm EST on August 13, 2010 to be considered for selection. Further information is available on our website at www.nyscf.org/ callforabstracts

Further conference information, including hotel pricing and cancellation policies, is also available online. For any further questions, please contact [email protected] or 212.787.4111 x 103 Panel Sessions Conference Sessions 8:15 – 8:45 Registration and Complimentary Breakfast

1:15 - 3:15 pm 8:45 – 8:50 Introduction: Susan L. Solomon Chief Executive Officer, NYSCF Welcome: Susan L. Solomon, Chief Executive Officer, NYSCF Leaders from foundations, venture capital, pharmaceutical, 8:50 – 8:55 Welcome: Allen M. Spiegel, MD biotechnology, and healthcare companies discuss what it will Dean, Albert Einstein College of Medicine take to get stem cell research from lab bench to bedside. There will be a 5-minute question and answer period Chair andM oderator following each presentation. Lee Rubin, PhD Harvard University

Panelists Chair: Robin Goland, MD Robi Blumenstein Naomi Berrie Diabetes Center President, CHDI Management/ CHDI Foundation Columbia University Medical Center Tony Evnin, PhD 9:00 – 9:20 Douglas A. Melton, PhD, Partner, Venrock Harvard University Ian Ratcliffe Degeneration and Regeneration in Type 1 Diabetes Chief Executive Officer, Stemgent Max Wallace 9:25 – 9:45 Camillo Ricordi, MD Chief Executive Officer, Accelerate Brain Cancer Cure University of Miami; Diabetes Research Institute Cellular Therapies and Regenerative Medicine 3:15 - 4:00 pm Break & Poster Session Strategies for Diabetes 9:50 – 10:10 Matthias Hebrok, PhD University of California San Francisco 4:00 – 6:00 pm Understanding Cellular Plasticity in the Pancreas Leading stem cell researchers and policy makers discuss the current regulatory challenges facing emerging regenerative medicine and 10:15 – 10:45 Break & Poster Session stem cell treatments, and examine the changes in policy that will be necessary to accelerate their development, evaluation and approval.

Chair Chair: Gordana Vunjak-Novakovic, PhD Susan L. Solomon Columbia University Medical Center Chief Executive Officer, The New York Stem Cell Foundation 10:45 – 11:05 Thomas A. Rando, MD, PhD Moderator Stanford University School of Medicine Michael Werner, JD Regulation of Quiescence and Activation of Muscle Executive Director, Alliance for Regenerative Medicine Stem Cells Panelists 11:10 – 11:30 Kenneth R. Chien, MD, PhD Arlene Y. Chiu, PhD Harvard University Director and Professor-in-Residence, Office of New Research Directed Differentiation and Reprogramming Towards Initiatives, Beckman Research Institute at City of Hope a Ventricular Heart Muscle Fate in ES and Ventricular Kevin C. Eggan, PhD iPS (ViPS) Cell Lines Chief Scientific Officer, The New York Stem Cell Foundation Associate Professor of Stem Cell and Regenerative Medicine, 11:35 – 11:55 Christine Mummery, PhD Harvard Stem Cell Institute Leiden University, The Netherlands Cardiovascular Derivatives of Human Pluripotent Donald W. Fink, Jr., PhD (Invited) Stem Cells in Disease and Drug Discovery Biologist/Regulatory Review Scientist in the Office of Cellular, Tissue and Gene Therapies, US Food and Drug Administration 12:00 – 1:00 Complimentary Lunch & Poster Session Mahendra Rao, MBBS, PhD Vice President of Research, Life Technologies Johns Hopkins University, Buck Institute on Aging

During breaks, participants are invited to view posters presented by NYSCF - Druckenmiller Fellows and other selected contributors About The New York Stem Cell Foundation The mission of The New York Stem Cell Foundation is to accelerate cures for the major diseases of our time through stem cell research. Our programs include: NYSCF Research Laboratory; Conferences and Symposia; The Fellowship Program; The NYSCF Innovator Awards Program for Early Career Investigators, and The NYSCF - Chair: Shahin Rafii, MD Robertson Prize. Weill Cornell Medical College For more information about The New York Stem Cell Foundation 1:10 – 1:30 Paul S. Frenette, MD and its programs, please visit www.nyscf.org Albert Einstein College of Medicine New Insight in the HSC Niche Board Of Directors Lorenz Studer, MD Roy Geronemus, MD Sally Temple, PhD Chairman Gordana Vunjak-Novakovic, PhD 1:35 – 2:05 John E. Dick, PhD Susan L. Solomon Irving L. Weissman, MD Chief Executive Officer Harold Varmus, MD (Emeritus) University of Toronto, Canada Marilyn G. Breslow *Executive Committee The Role of Stem Cells in Cancer Karen E. Burke, MD, PhD David A. Carmel Business Council Chuck Close Scott Bruder, MD, PhD Alan M. Cohen Eli Casdin John L. Eastman Geoff Duyk, MD, PhD Chair: Steven A. Goldman, MD, PhD Carol B. Einiger Corey Goodman, PhD University of Rochester Paul Goldberger Daniel Marshak, PhD Zach W. Hall, PhD George Scangos, PhD Richard Scheller, PhD 2:10 – 2:30 Thomas M. Jessell, PhD Richard J. Massey, PhD Mary Elizabeth Bunzel (Emeritus) Stephen Sherwin, MD Columbia University Medical Center Janet Felleman (Emeritus) Joop Sistermans Motor Neuron Diversity and its Implications Patrick Vallance, MD, PhD Leadership Council 2:35 – 2:55 Hongjun Song, PhD Russell L. Carson Current NYSCF – Johns Hopkins University School of Medicine Chuck Close Druckenmiller Fellows Fiona Druckenmiller Ting Chen, PhD Application of Neural Stem Cells for Study of Jodie and John Eastman The Rockefeller University Neurological Disorders Marlene Hess Elisa Cimetta, PhD Dorothy Lichtenstein Columbia University 3:00 – 3:30 Break & Poster Session Julian Robertson, Jr. Dieter Egli, PhD Jack Rudin The New York Stem Cell Foundation Stephanie & Fred Shuman Alice Shure Christopher Fasano, PhD Chair: Ruth Lehmann, PhD Noelle & Dick Wolf New York Neural Stem Cell Institute New York University School of Medicine Valentina Fossati, PhD Medical Advisory Board Mount Sinai School of Medicine 3:30 – 3:50 Thomas Graf, PhD Asa Abeliovich, MD, PhD Natalie Kim, PhD Ali H. Brivanlou, PhD Harvard University Center for Genomic Regulation and ICREA, Spain Chi Van Dang, MD, PhD Dung-Fang Lee, PhD Immune Cell Reprogramming Valina Dawson, PhD Mount Sinai School of Medicine Kevin C. Eggan, PhD * 3:55 – 4:15 Dieter Egli, PhD Gerald D. Fischbach, MD Gabsang Lee, PhD The New York Stem Cell Foundation Gordon Fishell, PhD Memorial Sloan-Kettering Cancer Center Reprogramming After Nuclear Transfer Paul S. Frenette, MD Ian Martin, PhD , PhD Johns Hopkins University 4:20 – 4:40 Marius Wernig, MD John D. Gearhart, PhD Marco Seandel, MD, PhD Robin Goland, MD Weill Medical College of Cornell University Stanford University School of Medicine Lee Goldman, MD, MPh Jae-won Shim, PhD Direct Conversion of Fibroblasts into Neurons Antonio M. Gotto, Jr., MD, DPhil Memorial Sloan-Kettering Cancer Center James Grifo, MD, PhD Zach W. Hall, PhD * Chutima Talchai, PhD Thomas M. Jessell, PhD Columbia University Medical Center 4:45 – 5:15 Fiona Watt, DPhil Gordon Keller, PhD Maya Tevlin, PhD Cambridge Research Insititute, UK Ruth Lehmann, PhD The Rockefeller University Rudolph Leibel, MD * Stem Cell-Niche Interactions in Kai Wang, MD, PhD Ihor Lemischka, PhD Columbia University Medical Center Mammalian Haifan Lin, PhD Dan R. Littman, MD, PhD Oren Ziv, PhD Douglas A. Melton, PhD * The Hebrew University, Israel Mark Noble, PhD 5:15 – 7:30 Posters presented by NYSCF - Druckenmiller Paul Nurse, PhD Fellows and other selected contributors Herbert Pardes, MD Shahin Rafii, MD Lee Rubin, PhD * Allen M. Spiegel, MD ww w 163 N e w Amste r Y ork , NY 10023 . n dam yscf.org

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1. NYSCF 2009 Stem Cell Policy Forum: Shifting Ground: (left to right) Celia Witten, MD, PhD; Kevin Eggan, PhD; Susan L. Solomon, JD; Story C. Landis, PhD; Insoo Hyun, PhD; Alice Park 2. Linheng Li, PhD 3. Irving Weissman, MD 4. Justin Ichida, PhD 5. Arturo Alvarez-Buylla, PhD 6. Janet Rossant, PhD, FRS, FRSC (Keynote Speaker) 7. Steven Goldman MD, PhD