Supplemental table1 Unique in nMPs

N Unused Name Peptides (95%) 3 197 Talin-1 OS=Homo sapiens 134 GN=TLN1 PE=1 SV=3 5 183.57 Filamin-A OS=Homo sapiens 134 GN=FLNA PE=1 SV=4 10 107.97 Vinculin OS=Homo sapiens 71 GN=VCL PE=1 SV=4 12 103.14 Myosin-9 OS=Homo sapiens 58 GN=MYH9 PE=1 SV=4 16 74.54 alpha-IIb OS=Homo 66 sapiens GN=ITGA2B PE=1 SV=3 22 64.89 OS=Homo sapiens 41 GN=GSN PE=1 SV=1 27 55.6 Actin, cytoplasmic 1 OS=Homo 87 sapiens GN=ACTB PE=1 SV=1 29 53.21 Apolipoprotein A-IV OS=Homo 37 sapiens GN=APOA4 PE=1 SV=3 35 46.15 Alpha-actinin-1 OS=Homo 31 sapiens GN=ACTN1 PE=1 SV=2 36 44.39 Heat shock cognate 71 kDa 30 OS=Homo sapiens GN=HSPA8 PE=1 SV=1 43 40.72 78 kDa glucose-regulated protein 26 OS=Homo sapiens GN=HSPA5 PE=1 SV=2 49 36.9 Tropomyosin alpha-4 chain 24 OS=Homo sapiens GN=TPM4 PE=1 SV=3 55 32 ATP synthase subunit beta, 21 mitochondrial OS=Homo sapiens GN=ATP5B PE=1 SV=3 63 28.97 Glyceraldehyde-3-phosphate 20 dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 66 28.19 Thrombospondin-1 OS=Homo 17 sapiens GN=THBS1 PE=1 SV=2 78 26.25 endothelial 17 molecule OS=Homo sapiens GN=PECAM1 PE=1 SV=1 80 25.93 Integrin beta-3 OS=Homo sapiens 19 GN=ITGB3 PE=1 SV=2 82 25.23 14-3-3 protein zeta/delta 20 OS=Homo sapiens GN=YWHAZ PE=1 SV=1 93 22.72 Apolipoprotein C-III OS=Homo 35 sapiens GN=APOC3 PE=1 SV=1 99 21.41 Tropomyosin alpha-3 chain 20 OS=Homo sapiens GN=TPM3 PE=1 SV=1 104 20.65 Ras-related protein Rap-1b 18 OS=Homo sapiens GN=RAP1B PE=1 SV=1 105 20.02 Protein APOC4-APOC2 22 OS=Homo sapiens GN=APOC4-APOC2 PE=4 SV=1 109 19.52 Protein disulfide-isomerase A3 11 OS=Homo sapiens GN=PDIA3 PE=1 SV=4 112 19.06 Fructose-bisphosphate aldolase 15 OS=Homo sapiens GN=ALDOA PE=1 SV=1 114 19.03 Tropomyosin 1 (Alpha), isoform 16 CRA_m OS=Homo sapiens GN=TPM1 PE=1 SV=1 116 18.84 A7 OS=Homo sapiens 9 GN=ANXA7 PE=1 SV=3 119 18.44 Histone H2B type 2-E OS=Homo 17 sapiens GN=HIST2H2BE PE=1 SV=3 121 18.24 Tubulin alpha-4A chain 12 OS=Homo sapiens GN=TUBA4A PE=1 SV=1 122 18.15 Adenylyl cyclase-associated 13 protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=5 123 18.12 Pyruvate kinase PKM OS=Homo 11 sapiens GN=PKM PE=1 SV=4 125 18.08 Endoplasmin OS=Homo sapiens 12 GN=HSP90B1 PE=1 SV=1 139 16.13 Heat shock 70 kDa protein 1B 16 OS=Homo sapiens GN=HSPA1B PE=4 SV=1 142 15.87 L- A chain 10 OS=Homo sapiens GN=LDHA PE=1 SV=2 147 15.51 (Platelet), alpha 13 polypeptide OS=Homo sapiens GN=GP1BA PE=1 SV=1 153 14.99 Ras-related protein Rab-27B 12 OS=Homo sapiens GN=RAB27B PE=1 SV=4 154 14.89 Tubulin beta chain OS=Homo 11 sapiens GN=TUBB PE=1 SV=1 156 14.84 Bridging integrator 2 OS=Homo 8 sapiens GN=BIN2 PE=1 SV=1 162 14.46 Ras-related protein Rab-11A 8 (Fragment) OS=Homo sapiens GN=RAB11A PE=3 SV=1 166 13.84 Myosin polypeptide 6 12 OS=Homo sapiens GN=MYL6 PE=1 SV=1 167 13.72 Actin-related protein 2 OS=Homo 10 sapiens GN=ACTR2 PE=1 SV=1 170 13.44 Pleckstrin OS=Homo sapiens 9 GN=PLEK PE=1 SV=3 175 13.13 Myosin regulatory light chain 12 12A OS=Homo sapiens GN=MYL12A PE=1 SV=1 186 12.51 L-lactate dehydrogenase B chain 8 OS=Homo sapiens GN=LDHB PE=1 SV=2 187 12.36 Peptidyl-prolyl cis-trans 6 isomerase B OS=Homo sapiens GN=PPIB PE=1 SV=2 188 12.36 , 7 mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 190 12.22 Transgelin-2 (Fragment) 9 OS=Homo sapiens GN=TAGLN2 PE=1 SV=1 200 11.43 Platelet glycoprotein V 7 OS=Homo sapiens GN=GP5 PE=1 SV=1 206 11.2 Ras-related protein Rab-1B 9 OS=Homo sapiens GN=RAB1B PE=1 SV=1 207 11.03 PDZ and LIM domain protein 1 8 OS=Homo sapiens GN=PDLIM1 PE=1 SV=4 209 10.87 Neutral alpha-glucosidase AB 6 OS=Homo sapiens GN=GANAB PE=1 SV=3 211 10.76 Voltage-dependent anion-selective 6 channel protein 1 OS=Homo sapiens GN=VDAC1 PE=1 SV=2 215 10.66 OS=Homo sapiens 8 GN=CALR PE=1 SV=1 216 10.57 Guanine nucleotide-binding 5 protein G(q) subunit alpha OS=Homo sapiens GN=GNAQ PE=1 SV=4 218 10.48 Apolipoprotein C-I (Fragment) 13 OS=Homo sapiens GN=APOC1 PE=1 SV=1 219 10.39 Guanine nucleotide-binding 7 protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens GN=GNB1 PE=1 SV=3 220 10.3 OS=Homo sapiens 10 GN=ANXA5 PE=1 SV=2 222 10.3 Apolipoprotein M OS=Homo 5 sapiens GN=APOM PE=1 SV=2 223 10.27 Multimerin-1 OS=Homo sapiens 6 GN=MMRN1 PE=1 SV=3 225 10.2 Platelet basic protein OS=Homo 7 sapiens GN=PPBP PE=1 SV=3 230 10.09 ATP synthase subunit alpha, 7 mitochondrial OS=Homo sapiens GN=ATP5A1 PE=1 SV=1 231 10 Tubulin beta-1 chain OS=Homo 9 sapiens GN=TUBB1 PE=1 SV=1 233 9.82 Ras-related protein Rab-7a 5 OS=Homo sapiens GN=RAB7A PE=1 SV=1 237 9.58 Actin-related protein 2/3 complex 9 subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 240 9.36 Glycogen phosphorylase, brain 5 form OS=Homo sapiens GN=PYGB PE=1 SV=5 244 9.29 Protein ARPC4-TTLL3 5 OS=Homo sapiens GN=ARPC4-TTLL3 PE=1 SV=1 247 9.18 OS=Homo sapiens 8 GN=CANX PE=1 SV=2 251 8.87 Heat shock protein HSP 90-alpha 4 OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 254 8.74 Serum deprivation-response 6 protein OS=Homo sapiens GN=SDPR PE=1 SV=3 255 8.6 Stress-70 protein, mitochondrial 5 OS=Homo sapiens GN=HSPA9 PE=1 SV=2 260 8.47 LIM and senescent cell 6 antigen-like-containing domain protein 1 OS=Homo sapiens GN=LIMS1 PE=1 SV=4 261 8.36 5 [NADP], mitochondrial OS=Homo sapiens GN=IDH2 PE=1 SV=2 263 8.23 Coronin OS=Homo sapiens 7 GN=CORO1C PE=1 SV=1 265 8.22 Thymidine phosphorylase 4 (Fragment) OS=Homo sapiens GN=TYMP PE=1 SV=1 266 8.21 60 kDa heat shock protein, 5 mitochondrial OS=Homo sapiens GN=HSPD1 PE=1 SV=2 270 8.07 Histone H2A type 1-C OS=Homo 9 sapiens GN=HIST1H2AC PE=1 SV=3 272 8.04 -1 catalytic subunit 4 OS=Homo sapiens GN=CAPN1 PE=1 SV=1 277 8 Platelet glycoprotein IX 6 OS=Homo sapiens GN=GP9 PE=1 SV=3 281 7.89 Zyxin OS=Homo sapiens 6 GN=ZYX PE=1 SV=1 296 7.28 Peptidyl-prolyl cis-trans 6 isomerase F, mitochondrial OS=Homo sapiens GN=PPIF PE=1 SV=1 297 7.25 NAD-dependent malic enzyme, 5 mitochondrial OS=Homo sapiens GN=ME2 PE=1 SV=1 303 6.98 Ras-related protein Rab-10 6 OS=Homo sapiens GN=RAB10 PE=1 SV=1 310 6.53 Alpha-actinin-4 OS=Homo 21 sapiens GN=ACTN4 PE=1 SV=2 311 6.53 Clathrin light chain A OS=Homo 4 sapiens GN=CLTA PE=1 SV=1 318 6.31 Myelin basic protein OS=Homo 3 sapiens GN=MBP PE=1 SV=3 325 6.16 Citrate synthase, mitochondrial 3 OS=Homo sapiens GN=CS PE=1 SV=2 326 6.15 Tropomyosin 1 (Alpha), isoform 13 CRA_f OS=Homo sapiens GN=TPM1 PE=1 SV=1 328 6.13 14-3-3 protein eta OS=Homo 8 sapiens GN=YWHAH PE=1 SV=4 329 6.13 Protein disulfide-isomerase A6 4 OS=Homo sapiens GN=PDIA6 PE=1 SV=1 334 6.08 14-3-3 protein gamma OS=Homo 8 sapiens GN=YWHAG PE=1 SV=2 342 6 Platelet factor 4 OS=Homo 5 sapiens GN=PF4 PE=1 SV=2 347 6 Malectin OS=Homo sapiens 3 GN=MLEC PE=1 SV=1 349 6 Septin-2 OS=Homo sapiens 3 GN=SEPT2 PE=1 SV=1 361 5.51 Protein diaphanous homolog 1 7 OS=Homo sapiens GN=DIAPH1 PE=4 SV=1 373 5.2 Hydroxyacyl-coenzyme A 6 dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=1 376 5.14 Platelet glycoprotein Ib beta chain 5 OS=Homo sapiens GN=GP1BB PE=1 SV=1 386 4.92 Actin-related protein 2/3 complex 3 subunit 3 OS=Homo sapiens GN=ARPC3 PE=1 SV=3 392 4.79 Endoplasmic reticulum resident 3 protein 44 OS=Homo sapiens GN=ERP44 PE=1 SV=1 401 4.45 c oxidase subunit 4 3 isoform 1, mitochondrial OS=Homo sapiens GN=COX4I1 PE=1 SV=1 402 4.44 Drebrin OS=Homo sapiens 3 GN=DBN1 PE=1 SV=4 406 4.39 C-type lectin domain family 1 2 member B OS=Homo sapiens GN=CLEC1B PE=1 SV=2 413 4.33 10 kDa heat shock protein, 3 mitochondrial OS=Homo sapiens GN=HSPE1 PE=1 SV=2 429 4.13 CD63 antigen OS=Homo sapiens 3 GN=CD63 PE=1 SV=1 432 4.09 Hexokinase-1 OS=Homo sapiens 6 GN=HK1 PE=1 SV=3 449 4.01 Protein kinase C beta type 2 OS=Homo sapiens GN=PRKCB PE=1 SV=4 453 4 Myosin regulatory light 11 polypeptide 9 OS=Homo sapiens GN=MYL9 PE=1 SV=4 454 4 Ras-related protein Rab-6B 6 OS=Homo sapiens GN=RAB6B PE=1 SV=1 464 4 ATP synthase subunit delta, 3 mitochondrial OS=Homo sapiens GN=ATP5D PE=1 SV=2 484 3.81 Syntaxin-binding protein 2 4 OS=Homo sapiens GN=STXBP2 PE=1 SV=2 485 3.8 HLA class I histocompatibility 8 antigen, B-81 alpha chain OS=Homo sapiens GN=HLA-B PE=1 SV=1 486 3.79 Superoxide dismutase OS=Homo 3 sapiens GN=SOD2 PE=1 SV=1 497 3.58 GTP:AMP phosphotransferase 3 AK3, mitochondrial OS=Homo sapiens GN=AK3 PE=1 SV=4 504 3.45 Actin-related protein 2/3 complex 3 subunit 2 OS=Homo sapiens GN=ARPC2 PE=1 SV=1 506 3.44 Ras GTPase-activating-like 5 protein IQGAP2 OS=Homo sapiens GN=IQGAP2 PE=1 SV=4 512 3.33 ATPase inhibitor, mitochondrial 2 OS=Homo sapiens GN=ATPIF1 PE=1 SV=1 519 3.14 -like protein 5 2 OS=Homo sapiens GN=CALML5 PE=1 SV=2 527 2.97 Guanine nucleotide-binding 5 protein subunit beta-4 OS=Homo sapiens GN=GNB4 PE=1 SV=3 529 2.96 ATP synthase-coupling factor 6, 2 mitochondrial OS=Homo sapiens GN=ATP5J PE=1 SV=1 530 2.92 oxidase subunit 2 5A, mitochondrial OS=Homo sapiens GN=COX5A PE=1 SV=1 534 2.82 Inverted formin-2 OS=Homo 7 sapiens GN=INF2 PE=1 SV=2 539 2.72 14-3-3 protein theta OS=Homo 8 sapiens GN=YWHAQ PE=1 SV=1 554 2.41 ATP synthase subunit e, 1 mitochondrial OS=Homo sapiens GN=ATP5I PE=1 SV=2 572 2.17 Actin-related protein 3B 1 OS=Homo sapiens GN=ACTR3B PE=2 SV=1 576 2.14 Lysosome-associated membrane 4 glycoprotein 1 OS=Homo sapiens GN=LAMP1 PE=1 SV=3 578 2.13 Vesicle-associated membrane 1 protein-associated protein A OS=Homo sapiens GN=VAPA PE=1 SV=3 588 2.09 Solute carrier family 2, facilitated 1 glucose transporter member 3 OS=Homo sapiens GN=SLC2A3 PE=2 SV=1 595 2.06 Actin-related protein 2/3 complex 2 subunit 1B OS=Homo sapiens GN=ARPC1B PE=1 SV=3 596 2.06 Integrin alpha-5 OS=Homo 2 sapiens GN=ITGA5 PE=1 SV=2 597 2.06 Trifunctional enzyme subunit 2 beta, mitochondrial OS=Homo sapiens GN=HADHB PE=1 SV=1 599 2.05 Tenascin OS=Homo sapiens 1 GN=TNC PE=1 SV=1 601 2.05 PRA1 family protein 3 OS=Homo 1 sapiens GN=ARL6IP5 PE=1 SV=1 609 2.04 Amine oxidase 1 [flavin-containing] B OS=Homo sapiens GN=MAOB PE=1 SV=3 610 2.04 -like protein 1 1 OS=Homo sapiens GN=HPCAL1 PE=1 SV=3 631 2.01 Ras GTPase-activating protein 3 1 OS=Homo sapiens GN=RASA3 PE=1 SV=3 632 2.01 Maestro heat-like 3 repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 677 2 Persulfide dioxygenase ETHE1, 5 mitochondrial OS=Homo sapiens GN=ETHE1 PE=1 SV=1 679 2 Trem-like transcript 1 protein 2 OS=Homo sapiens GN=TREML1 PE=1 SV=2 681 2 Leucine-rich repeat-containing 2 protein 59 OS=Homo sapiens GN=LRRC59 PE=1 SV=1 691 2 cGMP-specific 3',5'-cyclic 2 phosphodiesterase OS=Homo sapiens GN=PDE5A PE=1 SV=2 694 2 G2 and S phase-expressed protein 2 1 OS=Homo sapiens GN=GTSE1 PE=1 SV=3 695 2 Destrin OS=Homo sapiens 3 GN=DSTN PE=1 SV=3 697 2 T-complex protein 1 subunit zeta 2 OS=Homo sapiens GN=CCT6A PE=1 SV=3 703 2 Cytosol aminopeptidase 2 OS=Homo sapiens GN=LAP3 PE=1 SV=3 704 2 Serine/threonine-protein kinase 3 TAO1 OS=Homo sapiens GN=TAOK1 PE=1 SV=1 711 2 Serpin B6 OS=Homo sapiens 1 GN=SERPINB6 PE=1 SV=1 726 2 Striatin-4 OS=Homo sapiens 3 GN=STRN4 PE=1 SV=2 727 2 Calcineurin B homologous 2 protein 1 OS=Homo sapiens GN=CHP1 PE=1 SV=3 740 2 Prostaglandin G/H synthase 1 1 OS=Homo sapiens GN=PTGS1 PE=1 SV=2 748 2 Transforming growth factor 1 beta-1 OS=Homo sapiens GN=TGFB1 PE=1 SV=2 753 2 subunit 1 7A2, mitochondrial OS=Homo sapiens GN=COX7A2 PE=1 SV=1 754 2 Uncharacterized protein 1 OS=Homo sapiens PE=4 SV=1 756 2 Caspase-3 OS=Homo sapiens 1 GN=CASP3 PE=1 SV=2 761 2 Cytochrome b5 type B OS=Homo 2 sapiens GN=CYB5B PE=1 SV=1 765 2 Protein tweety homolog 3 1 OS=Homo sapiens GN=TTYH3 PE=1 SV=3 772 2 Tetraspanin OS=Homo sapiens 1 GN=TSPAN9 PE=1 SV=1 773 2 Cytochrome c oxidase assembly 1 factor 3 homolog, mitochondrial OS=Homo sapiens GN=COA3 PE=1 SV=1 776 2 Proteasome subunit beta type-6 1 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 796 1.87 HLA class I histocompatibility 11 antigen, A-24 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=2 815 1.63 Alpha-crystallin B chain 2 (Fragment) OS=Homo sapiens GN=CRYAB PE=1 SV=1 820 1.55 Calumenin OS=Homo sapiens 1 GN=CALU PE=1 SV=2 822 1.54 Twinkle protein, mitochondrial 1 OS=Homo sapiens GN=PEO1 PE=1 SV=1 826 1.52 Transmembrane emp24 1 domain-containing protein 2 OS=Homo sapiens GN=TMED2 PE=1 SV=1 828 1.51 Eukaryotic translation initiation 1 factor 4B OS=Homo sapiens GN=EIF4B PE=1 SV=1 830 1.5 Cytochrome c oxidase subunit 1 NDUFA4 OS=Homo sapiens GN=NDUFA4 PE=1 SV=1 1160.2 8.31 Haptoglobin-related protein 37 OS=Homo sapiens GN=HPR PE=2 SV=2 1160.3 2.01 Basement membrane-specific 4 heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 a), N:order number of the proteins in current study; b), Unused score: a measurement of all the peptide evidence for a protein that is not better explained by a higher ranking protein; c), Peptides (95%): The number of distinct peptides having at least 95% confidence.

Supplemental Table 2 Unique proteins in preo-MPs

N Unused Name Peptides (95%) 6 173.11 alpha chain OS=Homo 321 sapiens GN=FGA PE=1 SV=2 7 169.23 Fibronectin OS=Homo sapiens GN=FN1 198 PE=1 SV=4 13 98.06 OS=Homo sapiens 237 GN=FGB PE=1 SV=2 24 57.21 OS=Homo 132 sapiens GN=FGG PE=1 SV=1 38 43.31 OS=Homo 29 sapiens GN=VWF PE=1 SV=4 40 42.89 subunit beta OS=Homo 142 sapiens GN=HBB PE=1 SV=2 48 37.71 OS=Homo 101 sapiens GN=HBA1 PE=1 SV=2 50 36.8 Catalase OS=Homo sapiens GN=CAT 21 PE=1 SV=3 68 28.09 Transitional endoplasmic reticulum 18 ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 74 27.09 Keratin, type I cytoskeletal 10 15 OS=Homo sapiens GN=KRT10 PE=1 SV=6 88 23.75 Band 3 anion transport protein 17 OS=Homo sapiens GN=SLC4A1 PE=1 SV=3 96 21.93 Apolipoprotein(a) OS=Homo sapiens 13 GN=LPA PE=1 SV=1 98 21.73 Erythrocyte band 7 integral membrane 22 protein OS=Homo sapiens GN=STOM PE=1 SV=3 128 17.75 Peroxiredoxin-2 OS=Homo sapiens 13 GN=PRDX2 PE=1 SV=5 131 16.99 Carbonic anhydrase 1 OS=Homo sapiens 36 GN=CA1 PE=1 SV=2 144 15.85 Peroxiredoxin-6 OS=Homo sapiens 8 GN=PRDX6 PE=1 SV=3 146 15.72 Transthyretin OS=Homo sapiens 16 GN=TTR PE=1 SV=1 160 14.5 Carbonic anhydrase 2 OS=Homo sapiens 11 GN=CA2 PE=1 SV=2 161 14.48 Hemoglobin subunit delta OS=Homo 85 sapiens GN=HBD PE=1 SV=2 191 12.11 Fibulin-1 OS=Homo sapiens 7 GN=FBLN1 PE=1 SV=4 204 11.29 Oncoprotein-induced transcript 3 protein 9 OS=Homo sapiens GN=OIT3 PE=1 SV=2 210 10.83 Ras-related protein Rap-2b OS=Homo 8 sapiens GN=RAP2B PE=1 SV=1 212 10.75 Extracellular matrix protein 1 OS=Homo 6 sapiens GN=ECM1 PE=1 SV=2 228 10.1 HLA class I histocompatibility antigen, 15 A-66 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=1 242 9.3 Ras-related protein Ral-A OS=Homo 7 sapiens GN=RALA PE=1 SV=1 259 8.52 Annexin (Fragment) OS=Homo sapiens 5 GN=ANXA2 PE=1 SV=1 315 6.42 Fibulin 5, isoform CRA_a OS=Homo 4 sapiens GN=FBLN5 PE=1 SV=1 331 6.1 Solute carrier family 2, facilitated 3 glucose transporter member 1 OS=Homo sapiens GN=SLC2A1 PE=1 SV=2 343 6 OS=Homo 7 sapiens GN=HBZ PE=1 SV=2 382 5.01 Disintegrin and metalloproteinase 4 domain-containing protein 10 OS=Homo sapiens GN=ADAM10 PE=1 SV=1 389 4.86 Radixin OS=Homo sapiens GN=RDX 14 PE=1 SV=1 393 4.74 Bisphosphoglycerate mutase OS=Homo 3 sapiens GN=BPGM PE=1 SV=2 403 4.42 Fetuin-B OS=Homo sapiens 2 GN=FETUB PE=1 SV=1 483 3.85 Glycophorin-C OS=Homo sapiens 2 GN=GYPC PE=1 SV=1 494 3.66 Lymphocyte function-associated antigen 2 3 (Fragment) OS=Homo sapiens GN=CD58 PE=1 SV=1 521 3.1 Golgi-associated plant 3 pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 800 1.82 Fibulin-1 OS=Homo sapiens 3 GN=FBLN1 PE=1 SV=1 844 1.36 Pyruvate dehydrogenase phosphatase 1 regulatory subunit, mitochondrial OS=Homo sapiens GN=PDPR PE=1 SV=2 1188 169.23 Fibronectin OS=Homo sapiens GN=FN1 198 PE=1 SV=4 a), N:order number of the proteins in current study; b), Unused score: a measurement of all the peptide evidence for a protein that is not better explained by a higher ranking protein; c), Peptides (95%): The number of distinct peptides having at least 95% confidence. Supplemental table 3 Unique proteins in posto-MPs

N Unused Name Peptides (95%) 2 213.36 Complement C3 OS=Homo sapiens GN=C3 222 PE=1 SV=2 8 152.51 Alpha-2-macroglobulin OS=Homo sapiens 188 GN=A2M PE=1 SV=3 9 119.3 Complement C4-B OS=Homo sapiens 90 GN=C4B PE=1 SV=2 15 84.77 Alpha-1-antitrypsin OS=Homo sapiens 169 GN=SERPINA1 PE=1 SV=3 19 70.71 Ceruloplasmin OS=Homo sapiens GN=CP 72 PE=1 SV=1 20 69.33 Uncharacterized protein OS=Homo sapiens 44 PE=1 SV=1 21 67.71 Inter-alpha-trypsin inhibitor heavy chain H4 66 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 25 56.61 Complement C5 OS=Homo sapiens GN=C5 36 PE=1 SV=4 26 55.85 Alpha-1-antichymotrypsin OS=Homo sapiens 63 GN=SERPINA3 PE=1 SV=2 31 52.27 Haptoglobin OS=Homo sapiens GN=HP PE=1 85 SV=1 33 50.66 -III OS=Homo sapiens 35 GN=SERPINC1 PE=1 SV=1 39 43.08 Hemopexin OS=Homo sapiens GN=HPX 45 PE=1 SV=2 45 40.3 Vitamin D-binding protein OS=Homo sapiens 35 GN=GC PE=1 SV=1 47 39.26 Collagen alpha-1(I) chain OS=Homo sapiens 62 GN=COL1A1 PE=1 SV=5 53 33.19 Myeloperoxidase OS=Homo sapiens 27 GN=MPO PE=1 SV=1 60 30.42 Plasma protease C1 inhibitor OS=Homo 26 sapiens GN=SERPING1 PE=1 SV=2 69 27.71 Ig alpha-1 chain C region OS=Homo sapiens 81 GN=IGHA1 PE=1 SV=2 72 27.34 Alpha-1-acid glycoprotein 1 OS=Homo 43 sapiens GN=ORM1 PE=1 SV=1 73 27.24 Zinc-alpha-2-glycoprotein OS=Homo sapiens 20 GN=AZGP1 PE=1 SV=2 76 26.57 Complement C1s subcomponent OS=Homo 21 sapiens GN=C1S PE=1 SV=1 77 26.44 Leucine-rich alpha-2-glycoprotein OS=Homo 18 sapiens GN=LRG1 PE=1 SV=2 79 26.01 Pigment epithelium-derived factor OS=Homo 14 sapiens GN=SERPINF1 PE=1 SV=4 81 25.88 Inter-alpha-trypsin inhibitor heavy chain H3 17 OS=Homo sapiens GN=ITIH3 PE=1 SV=2 84 25.04 Complement component C9 OS=Homo sapiens 15 GN=C9 PE=1 SV=2 100 21.36 Complement factor I OS=Homo sapiens 16 GN=CFI PE=1 SV=1 101 21.2 Complement component C6 OS=Homo sapiens 14 GN=C6 PE=1 SV=3 106 19.92 Annexin A4 OS=Homo sapiens GN=ANXA4 10 PE=1 SV=4 113 19.04 OS=Homo sapiens GN=ANXA1 12 PE=1 SV=2 132 16.9 protein 1 OS=Homo 11 sapiens GN=TFRC PE=1 SV=2 140 15.94 HLA class I histocompatibility antigen, B-15 14 alpha chain OS=Homo sapiens GN=HLA-B PE=1 SV=2 150 15.21 Angiotensinogen OS=Homo sapiens GN=AGT 9 PE=1 SV=1 151 15.18 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 10 SV=6 155 14.85 Protein S100-A8 OS=Homo sapiens 15 GN=S100A8 PE=1 SV=1 164 14.35 Protein IGHV3-30 (Fragment) OS=Homo 28 sapiens GN=IGHV3-30 PE=1 SV=1 171 13.33 Lactotransferrin OS=Homo sapiens GN=LTF 14 PE=1 SV=1 172 13.27 Complement component C8 beta chain 7 OS=Homo sapiens GN=C8B PE=1 SV=3 176 13.11 Matrix metalloproteinase-9 OS=Homo sapiens 8 GN=MMP9 PE=1 SV=3 177 13.03 Complement component C8 alpha chain 6 OS=Homo sapiens GN=C8A PE=1 SV=2 180 12.91 Protein S100-A9 OS=Homo sapiens 11 GN=S100A9 PE=1 SV=1 183 12.85 Carboxypeptidase N subunit 2 OS=Homo 9 sapiens GN=CPN2 PE=1 SV=3 192 12.09 Complement component C7 OS=Homo sapiens 8 GN=C7 PE=1 SV=2 196 11.94 C-reactive protein OS=Homo sapiens 6 GN=CRP PE=1 SV=1 235 9.78 Alpha-1-acid glycoprotein 2 OS=Homo 21 sapiens GN=ORM2 PE=1 SV=2 238 9.51 Serum amyloid A-1 protein OS=Homo sapiens 26 GN=SAA1 PE=1 SV=1 245 9.27 Uncharacterized protein OS=Homo sapiens 141 PE=4 SV=1 257 8.54 Lipopolysaccharide-binding protein OS=Homo 4 sapiens GN=LBP PE=1 SV=3 271 8.05 Copine-3 OS=Homo sapiens GN=CPNE3 4 PE=1 SV=1 274 8.01 Alkaline phosphatase, tissue-nonspecific 4 isozyme OS=Homo sapiens GN=ALPL PE=1 SV=4 283 7.85 Cathelicidin antimicrobial peptide OS=Homo 8 sapiens GN=CAMP PE=1 SV=1 284 7.85 Brain acid soluble protein 1 OS=Homo sapiens 6 GN=BASP1 PE=1 SV=2 295 7.42 Serum amyloid P-component OS=Homo 6 sapiens GN=APCS PE=1 SV=2 305 6.91 Carboxypeptidase N catalytic chain OS=Homo 4 sapiens GN=CPN1 PE=1 SV=1 306 6.8 Lysozyme C OS=Homo sapiens GN=LYZ 6 PE=1 SV=1 355 5.82 C4b-binding protein beta chain OS=Homo 4 sapiens GN=C4BPB PE=1 SV=1 360 5.68 Complement C1r subcomponent-like protein 6 OS=Homo sapiens GN=C1RL PE=1 SV=2 370 5.26 Neutrophil gelatinase-associated lipocalin 4 OS=Homo sapiens GN=LCN2 PE=1 SV=1 398 4.62 Ig lambda chain V-VI region EB4 OS=Homo 9 sapiens PE=2 SV=1 439 4.03 Protein S100-A11 OS=Homo sapiens 2 GN=S100A11 PE=1 SV=2 452 4 Uncharacterized protein OS=Homo sapiens 50 PE=4 SV=1 479 3.95 Grancalcin (Fragment) OS=Homo sapiens 2 GN=GCA PE=1 SV=1 493 3.68 CD177 antigen OS=Homo sapiens GN=CD177 2 PE=1 SV=1 561 2.28 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 31 575 2.15 Protein S100-A12 OS=Homo sapiens 1 GN=S100A12 PE=1 SV=2 602 2.04 Ig heavy chain V-III region CAM OS=Homo 28 sapiens PE=1 SV=1 639 2 Alpha-1-antitrypsin OS=Homo sapiens 166 GN=SERPINA1 PE=3 SV=1 642 2 Ig heavy chain V-III region 23 OS=Homo 61 sapiens GN=IGHV3-23 PE=1 SV=2 645 2 Protein IGHV3-66 (Fragment) OS=Homo 31 sapiens GN=IGHV3-66 PE=4 SV=1 651 2 Ig lambda chain V-I region VOR OS=Homo 16 sapiens PE=1 SV=1 657 2 Protein IGLV2-11 (Fragment) OS=Homo 6 sapiens GN=IGLV2-11 PE=1 SV=1 665 2 Testis-expressed sequence 9 protein OS=Homo 3 sapiens GN=TEX9 PE=2 SV=1 669 2 Protein IGHV3-38 (Fragment) OS=Homo 4 sapiens GN=IGHV3-38 PE=1 SV=1 696 2 Vasorin OS=Homo sapiens GN=VASN PE=1 1 SV=1 725 2 Meiosis-specific protein MEI4-like OS=Homo 1 sapiens GN=MEI4 PE=3 SV=2 738 2 DnaJ homolog subfamily C member 2 1 OS=Homo sapiens GN=DNAJC2 PE=1 SV=4 741 2 L-seryl-tRNA(Sec) kinase (Fragment) 1 OS=Homo sapiens GN=PSTK PE=1 SV=1 790 2 CD59 glycoprotein OS=Homo sapiens 1 GN=CD59 PE=1 SV=1 805 1.8 family 16 member 1 A1 OS=Homo sapiens GN=ALDH16A1 PE=1 SV=2 839 1.41 Protein IGHV3-64 OS=Homo sapiens 14 GN=IGHV3-64 PE=1 SV=1 1160.1 13.27 Complement component C8 beta chain 7 OS=Homo sapiens GN=C8B PE=1 SV=3 1191 67.71 Inter-alpha-trypsin inhibitor heavy chain H4 66 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 a), N:order number of the proteins in current study; b), Unused score: a measurement of all the peptide evidence for a protein that is not better explained by a higher ranking protein; c), Peptides (95%): The number of distinct peptides having at least 95% confidence.