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Spring 2021 Bulletin
Advancing Access to Civil Justice STEPS TOWARD INTERNATIONAL CLIMATE GOVERNANCE Featuring William Nordhaus, Pinelopi Goldberg, and Scott Barrett HONORING WILLIAM LABOV, RUTH LEHMANN , AND GERTRUD SCHÜPBACH SPRING 2021 SELECT UPCOMING VIRTUAL EVENTS May 6 A Conversation with Architect 27 Reflections on a Full, Consequential, Jeanne Gang and Lucky Life: Science, Leadership, Featuring: Jeanne Gang and Education Featuring: Walter E. Massey (left) in conversation with Don Randel (right) June 14 Lessons Learned from Reckoning with Organizational History Featuring: John J. DeGioia, Brent Leggs, Susan Goldberg, Claudia Rankine, and Ben Vinson 13 Finding a Shared Narrative Hosted by the Library of Congress Featuring: Danielle Allen, winner of the Library’s 2020 Kluge Prize Above: “Our Common Purpose” featuring the Juneteenth flag with one star. Artist: Rodrigo Corral For a full and up-to-date listing of upcoming events, please visit amacad.org/events. SPRING 2021 CONTENTS Flooding beside the Russian River on Westside Road in Healdsburg, Sonoma County, California; February 27, 2019. Features 16 Steps Toward International 38 Honoring Ruth Lehmann and Gertrud Climate Governance Schüpbach with the Francis Amory Prize William Nordhaus, Pinelopi Goldberg, and Scott Barrett Ruth Lehmann and Gertrud Schüpbach 30 Honoring William Labov with the Talcott Parsons Prize William Labov CONTENTS 5 Among the contributors to the Dædalus issue on “Immigration, Nativism & Race” (left to right): Douglas S. Massey (guest editor), Christopher Sebastian Parker, and Cecilia Menjívar Our Work 5 Dædalus Explores Immigration, Nativism & Race in the United States 7 Advancing Civil Justice Access in the 21st Century 7 10 New Reports on the Earnings & Job Outcomes of College Graduates 14 Our Common Purpose in Communities Across the Country Members 53 In Memoriam: Louis W. -
Pipsqueak, an Early Acting Member of the Posterior Group of Genes, Affects Vasa Level and Germ Cell-Somatic Cell Interaction in the Developing Egg Chamber
Development 119, 1187-1202 (1993) 1187 Printed in Great Britain © The Company of Biologists Limited 1993 pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber Vivian Siegel*, Thomas A. Jongens, Lily Yeh Jan and Yuh Nung Jan Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94143-0724, USA *Author for correspondence SUMMARY We have identified a new member of the posterior group through vasa; molecular studies indicate that pipsqueak of genes, which we call pipsqueak. We show that affects vasa level in the ovary. We compare vasa and pipsqueak acts after the establishment of the oskar pipsqueak mutant phenotypes in order to determine posterior anchor but before the localization of vasa whether pipsqueak acts solely through vasa, and present protein during oogenesis. Characterization of multiple a model for the role of pipsqueak in posterior pattern alleles at the pipsqueak locus shows that pipsqueak, like formation. vasa, is required for early stages of oogenesis, including but not limited to formation of the egg chamber and pro- gression through Stage 6 of oogenesis. Genetic interac- Key words: Drosophila, oogenesis, posterior pattern formation, tion studies suggest that pipsqueak acts at least partially pipsqueak, vasa INTRODUCTION known collectively as posterior group genes of the grand- childless class, all seem to affect the formation of electron Pattern formation along the anteroposterior axis of the dense particles called polar granules, which are thought to Drosophila melanogaster embryo is initiated prior to fertil- consist of both protein and RNA, and which are localized to ization. -
Phase Transitioned Nuclear Oskar Promotes Cell Division of Drosophila Primordial Germ Cells
bioRxiv preprint doi: https://doi.org/10.1101/397992; this version posted August 22, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. PHASE TRANSITIONED NUCLEAR OSKAR PROMOTES CELL DIVISION OF DROSOPHILA PRIMORDIAL GERM CELLS Kathryn E. Kistler*1,2, Tatjana Trcek*†1, Thomas R. Hurd1, Ruoyu Chen1, Feng-Xia Liang3, Joseph Sall3, Masato Kato4, Ruth Lehmann†1 1: HHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, NY, USA 2: Department of Molecular and Cellular Biology, University of Washington, WA, USA 3: DART Microscopy Laboratory, NYU Langone Health, NY, USA 4: Department of Biochemistry, University of Texas Southwestern Medical Center, TX, USA ORCID ID Trcek Tatjana: 0000-0003-4405-8733 *: equal contribution †: correspondence ([email protected]; [email protected]) ABSTRACT Germ granules are non-membranous ribonucleoprotein granules deemed the hubs for post-transcriptional gene regulation and functionally linked to germ cell fate across species. Little is known about the physical properties of germ granules and how these relate to germ cell function. Here we study two types of germ granules in the Drosophila embryo: cytoplasmic germ granules that instruct primordial germ cells (PGCs) formation and nuclear germ granules within early PGCs with unknown function. We show that cytoplasmic and nuclear germ granules are phase transitioned condensates nucleated by Oskar protein that display liquid as well as hydrogel-like properties. -
Experimental Investigations of Contact Friction and Transport Properties of Monolayer and Bilayer Graphene
Graduate Theses, Dissertations, and Problem Reports 2021 Experimental Investigations of Contact Friction and Transport Properties of Monolayer and Bilayer Graphene Prakash Gajurel [email protected] Follow this and additional works at: https://researchrepository.wvu.edu/etd Part of the Condensed Matter Physics Commons Recommended Citation Gajurel, Prakash, "Experimental Investigations of Contact Friction and Transport Properties of Monolayer and Bilayer Graphene" (2021). Graduate Theses, Dissertations, and Problem Reports. 7994. https://researchrepository.wvu.edu/etd/7994 This Dissertation is protected by copyright and/or related rights. It has been brought to you by the The Research Repository @ WVU with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you must obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in WVU Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of The Research Repository @ WVU. For more information, please contact [email protected]. Graduate Theses, Dissertations, and Problem Reports 2021 EXPERIMENTAL INVESTIGATIONS OF CONTACT FRICTION AND TRANSPORT PROPERTIES OF MONOLAYER AND BILAYER GRAPHENE Prakash Gajurel Follow this and additional works at: https://researchrepository.wvu.edu/etd Part of the Condensed Matter Physics Commons EXPERIMENTAL INVESTIGATIONS OF CONTACT FRICTION AND TRANSPORT PROPERTIES OF MONOLAYER AND BILAYER GRAPHENE Prakash Gajurel Dissertation submitted to the Eberly College of Arts and Sciences at West Virginia University in partial fulfillment of the requirements for the degree of Doctor of Philosophy In Physics Mikel Holcomb, Ph.D., Chair Wathiq Abdul -Razzaq, Ph.D. -
Friday, September 19
Building the New York Stem Cell Community CUNY Graduate Center PROGRAM COMMITTEE Ira S. Cohen, M.D., Ph.D., Stony Brook University Steven Goldman, M.D., Ph.D., University of Rochester Ruth Lehmann, Ph.D., New York University School of Medicine Ihor Lemischka, Ph.D., Mount Sinai School of Medicine Lorenz Studer, M.D., Sloan-Kettering Institute Gordana Vunjak-Novakovic, Ph.D., Columbia University Scott Noggle, Ph.D., New York Stem Cell Foundation (Facilities Workshop) Sally Temple, Ph.D., New York Neural Stem Cell Institute (Facilities Workshop) ORGANIZING COMMITTEE David Anders, Ph.D., Chair Chief Scientific Officer, NYSTEM Linda Tripoli, R.N., Program Coordinator, NYSTEM Matthew Kohn, Ph.D., Scientific Officer, NYSTEM Kathy Chou, Ph.D., Scientific Officer, NYSTEM Marti McHugh, Director, Clinical Program Development Virginia Reyes The Wadsworth Center Photography and Illustrations Unit Tracy Godfrey PROGRAM-AT-A-GLANCE PROGRAM-AT-A-GLANCE MAY 26 – Elebash Recital Hall 8:00 AM Registration Opens and Continental Breakfast – Recital Hall Lobby 9:00 AM Shared Equipment and Facilities Workshop – Part 1 10:15 AM Break 10:30 AM Shared Equipment and Facilities Workshop – Part 2 12:00 PM Lunch – Concourse Lobby (one floor down) 1:20 PM Opening Remarks 1:30 PM Session I: Neural Stem Cells 3:00 PM Break 3:30 PM Session II: Stem Cells and Cancer 5:00 PM Reception/Poster Session – Concourse Lobby (one floor down) MAY 27 – Elebash Recital Hall 8:00 AM Registration Opens and Continental Breakfast – Recital Hall Lobby 9:00 AM Session III: Stem Cells in Diseases 10:30 AM Break 11:00 AM Session IV: Stem Cell Biology 12:30 PM Lunch – Ninth Floor Conference Room 1:30 PM Session V: Tissue Engineering and Technology 3:00 PM Break 3:30 PM Session VI: Pluripotency and Reprogramming 5:00 PM Adjourn WELCOME STATE OF NEW YORK DEPARTMENT OF HEALTH Wadsworth Center The Governor Nelson A. -
About Whitehead Institute for Biomedical Research Selected
About Whitehead Institute for Biomedical Research Selected Achievements in FOUNDING VISION Biomedical Science Whitehead Institute is a nonprofit, independent biomedical research institute with pioneering programs in cancer research, developmental biology, genetics, and Isolated the first tumor suppressor genomics. It was founded in 1982 through the generosity of Edwin C. "Jack" Whitehead, gene, the retinoblastoma gene, and a businessman and philanthropist who sought to create a new type of research created the first genetically defined institution, one that would exist outside the boundaries of a traditional academic human cancer cells. (Weinberg) institution, and yet, through a teaching affiliation with the Massachusetts Institute of Technology (MIT), offer all the intellectual, collegial, and scientific benefits of a leading Isolated key genes involved in diabetes, research university. hypertension, leukemia, and obesity. (Lodish) WHITEHEAD INSTITUTE TODAY True to its founding vision, the Institute gives outstanding investigators broad freedom Mapped and cloned the male- to pursue new ideas, encourages novel collaborations among investigators, and determining Y chromosome, revealing a accelerates the path of scientific discovery. Research at Whitehead Institute is unique self-repair mechanism. (Page) conducted by 22 principal investigators (Members and Fellows) and approximately 300 visiting scientists, postdoctoral fellows, graduate students, and undergraduate Developed a method for genetically students from around the world. Whitehead Institute is affiliated with MIT in its engineering salt- and drought-tolerant teaching activities but wholly responsible for its own research programs, governance, plants. (Fink) and finance. Developed the first comprehensive cellular LEADERSHIP network describing how the yeast Whitehead Institute is guided by a distinguished Board of Directors, chaired by Sarah genome produces life. -
Phase Separated Assemblies in Cell Biology
MEETING AGENDA Phase Separated Assemblies in Cell Biology The Banbury Center, Cold Spring Harbor Laboratory, New York, USA December 16-19, 2018 This meeting was funded by the Cold Spring Harbor Laboratory Corporate Sponsor Program Organizers: Arup K. Chakraborty, Massachusetts Institute of Technology; Geraldine Seydoux, Johns Hopkins University; Richard Young, Whitehead Institute for Biomedical Research; with Consulting Organizer, Phillip Sharp, Koch Institute for Integrative Cancer Research This Banbury meeting brought together an interdisciplinary group of experts to: review functions and types of phase-separated assemblies in biology; develop a common conceptual framework and nomenclature; identify molecular code characteristics underlying assemblies; consider pathologies caused by aberrant phase-separated assemblies; and examine manipulation of phase- separated assemblies as a novel treatment target. SUNDAY, DECEMBER 16 Afternoon Participant arrivals 6:00 pm Reception, dinner MONDAY, DECEMBER 17 7:15 am Breakfast at Robertson House 8:30 am Welcoming and Introductory Remarks Rebecca Leshan, The Banbury Center, Cold Spring Harbor Laboratory Arup Chakraborty, Massachusetts Institute of Technology, Cambridge, USA Geraldine Seydoux, Johns Hopkins University, Baltimore, USA Rick Young, Whitehead Institute for Biomedical Research, Cambridge, USA December 16-19, 2018 | Phase Separated Assemblies in Cell Biology | 1 8:45 am SESSION 1: Physical Principles Clifford Brangwynne, Princeton University, Princeton, USA Arup Chakraborty, Massachusetts -
Whitehead Faculty and Fellows Members
Whitehead Faculty and Fellows Members Ask a visiting scientist to describe Whitehead Institute and three themes David Bartel studies microRNAs and other small RNAs emerge immediately: the exceptional quality of the scientific staff, the that specify the destruction and/or translational collaborative spirit, and the ethos that encourages researchers at every level repression of mRNAs. He also studies mRNAs, focusing to share new ideas and benefit from the insights and experience of their on their untranslated regions and poly(A) tails, and colleagues. how these regions recruit and mediate regulatory processes. His lab found that microRNAs affect most human protein-coding genes, either by regulating The key to this combination of excellence and accessibility is, of course, the them or by shaping their evolution. Faculty. “From the beginning, we sought researchers who had terrific scientific instincts, but we were also looking for people who would feel comfortable in Iain Cheeseman investigates the process of our open environment,” says Founding Member Gerald Fink. “The exchange chromosome segregation and cell division. In of energy and new ideas never stops, from the formal research retreat, to the particular, he uses proteomics, biochemistry, cell faculty lunches, to the countless informal conversations in hallways and biology, and functional approaches to examine the lounges.” composition, structure, organization and function of the kinetochore — the group of proteins that assemble Whitehead Institute faculty, known as Members, are selected through a joint at the centromere and are required for chromosome appointment process with the Massachusetts Institute of Technology (MIT) segregation and cell division. Department of Biology. Whitehead Institute is solely responsible for their salary and research. -
Never Stop Asking Why
2013 2013 r ese A rch r eport Never Stop aSkiNg Why Research 2013 Report nyu s chool o F m edicine 550 First Avenue, n ew york, ny 10016 nyulmc.org For some, “Why is the sky blue?” is only the beginning. the best explorers never lose the Wonder ofoF youth even as they gain the grit to pursue bold ideas and the Foresight to take in the big picture. the researchers We recently recruited constantly remind us that great Wisdom can come From asking simple questions and From seeking the ansWers together. they love their Work and they love Where they Work. CREDITS Special thanks to Mary Englert and Linda Miller, content coordinators for the Published Research, New Faculty, Funding and Honors sections; to Laura Ahlborn, Ying Yu, Jeff Binder, Susan Digeronimo-Wild, Liz Donathan, Renée Davis, and Nancy Rieger for contributing the content for these sections; and to copy editor Annie Chin. science Images: Page 7, Courtesy of Dr. Dayu Lin; Page 8, Courtesy of Dr. Neils Ringstadt; Page 11, Courtesy of Dr. Victor Torres; Page 14, Courtesy of Dr. Agnel Sfeir; Page 19, Courtesy of Dr. Ilseung Cho; Page 25, Courtesy of Dr. Mayumi Ito; Page 26, Courtesy of Dr. Jeffrey Berger; Page 33, Courtesy of Dr. Kathryn Moore; Page 34, Courtesy of Dr. Evgeny Nudler. Journal cover Images: Page 30, reprinted with permission from Cell, Volume 153, Number 7, June 20 2013, Photograph by Alex Wild, University of Illinois; Page 44, Nature Neuroscience, January 2012, Volume 15, Number 1, reprinted with permission from the Nature Publishing Group; Page 45, Reprinted with permission -
Requirement for Highly Efficient Pre-Mrna Splicing During
RESEARCH ARTICLE elifesciences.org Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development Leonardo Gastón Guilgur1,2,3, Pedro Prudêncio1,2,3, Daniel Sobral1, Denisa Liszekova1, André Rosa1, Rui Gonçalo Martinho1,2,3* 1Instituto Gulbenkian de Ciência, Oeiras, Portugal; 2Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal; 3IBB-Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Faro, Portugal Abstract Drosophila syncytial nuclear divisions limit transcription unit size of early zygotic genes. As mitosis inhibits not only transcription, but also pre-mRNA splicing, we reasoned that constraints on splicing were likely to exist in the early embryo, being splicing avoidance a possible explanation why most early zygotic genes are intronless. We isolated two mutant alleles for a subunit of the NTC/Prp19 complexes, which specifically impaired pre-mRNA splicing of early zygotic but not maternally encoded transcripts. We hypothesized that the requirements for pre-mRNA splicing efficiency were likely to vary during development. Ectopic maternal expression of an early zygotic pre-mRNA was sufficient to suppress its splicing defects in the mutant background. Furthermore, a small early zygotic transcript with multiple introns was poorly spliced in wild-type embryos. Our findings demonstrate for the first time the existence of a developmental pre-requisite for highly efficient splicing during Drosophila early embryonic development and suggest in highly proliferative tissues a need for coordination between cell cycle and gene architecture to ensure correct gene expression and avoid abnormally processed transcripts. DOI: 10.7554/eLife.02181.001 *For correspondence: [email protected] Competing interests: The authors declare that no Introduction competing interests exist. -
Arxiv:2103.08851V2 [Cond-Mat.Mes-Hall] 28 Mar 2021
Macroscopically degenerate localized zero-energy states of quasicrystalline bilayer systems in strong coupling limit 1 1, 2, 3, Hyunsoo Ha and Bohm-Jung Yang ∗ 1Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea 2Center for Correlated Electron Systems, Institute for Basic Science (IBS), Seoul 08826, Korea 3Center for Theoretical Physics (CTP), Seoul National University, Seoul 08826, Korea (Dated: March 30, 2021) When two identical two-dimensional (2D) periodic lattices are stacked in parallel after rotating one layer by a certain angle relative to the other layer, the resulting bilayer system can lose lattice periodicity completely and become a 2D quasicrystal. Twisted bilayer graphene with 30◦ rotation is a representative example. We show that such quasicrystalline bilayer systems generally develop macroscopically degenerate localized zero-energy states (ZESs) in strong coupling limit where the interlayer couplings are overwhelmingly larger than the intralayer couplings. The emergent chiral symmetry in strong coupling limit and aperiodicity of bilayer quasicrystals guarantee the existence of the ZESs. The macroscopically degenerate ZESs are analogous to the flat bands of periodic systems, in that both are composed of localized eigenstates, which give divergent density of states. For monolayers, we consider the triangular, square, and honeycomb lattices, comprised of homogenous tiling of three possible planar regular polygons: the equilateral triangle, square, and regular hexagon. We construct a compact theoretical framework, which we call the quasiband model, that describes the low energy properties of bilayer quasicrystals and counts the number of ZESs using a subset of Bloch states of monolayers. We also propose a simple geometric scheme in real space which can show the spatial localization of ZESs and count their number. -
What Drives Superconductivity in Twisted Bilayer Graphene?
Journal Club for Condensed Matter Physics DOI:10.36471/JCCM_May_2020_03 https://www.condmatjclub.org What drives superconductivity in twisted bilayer graphene? 1. The interplay of insulating and superconducting orders in magic- angle graphene bilayers Authors: Petr Stepanov, Ipsita Das, Xiaobo Lu, Ali Fahimniya, Kenji Watanabe, Takashi Taniguchi, Frank H. L. Koppens, Johannes Lischner, Leonid Levitov, Dmitri K. Efetov https://arxiv.org/abs/1911.09198 2. Decoupling superconductivity and correlated insulators in twisted bilayer graphene Authors: Yu Saito, Jingyuan Ge, Kenji Watanabe, Takashi Taniguchi, and Andrea F. Young https://arxiv.org/abs/1911.13302 3. Tuning electron correlation in magic-angle twisted bilayer graphene using Coulomb screening Authors: Xiaoxue Liu, Zhi Wang, K. Watanabe, T. Taniguchi, Oskar Vafek, J. I. A. Li https://arxiv.org/abs/2003.11072 4. Nematicity and Competing Orders in Superconducting Magic-Angle Graphene Authors: Yuan Cao, Daniel Rodan-Legrain, Jeong Min Park, Fanqi Noah Yuan, Kenji Watanabe, Takashi Taniguchi, Rafael M. Fernandes, Liang Fu, Pablo Jarillo-Herrero https://arxiv.org/abs/2004.04148 Recommended with a Commentary by T. Senthil, Massachusetts Institute of Technology, USA. When two layers of graphene are stacked on top of each other with a small relative twist, a long period moire pattern forms. For the electronic states, this moire superlattice defines a new mini-Brillouin zone determined by the long real space period. Early theory[1] showed that near certain ``magic angles” these reconstructed electronic bands have very narrow bandwidths, comparable or lower than the estimated strength of Coulomb interactions between the electrons. This makes twisted bilayer graphene (TBLG) a possible platform for correlated electron physics in a tunable two dimensional material.