Record #1 of 15

ID: CN-00801300

AU: Wu W

AU: Cannon PS

AU: Yan W

AU: Tu Y

AU: Selva D

AU: Qu J

TI: Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryocystorhinostomy for primary chronic dacryocystitis.

SO: Eye (London, England)

YR: 2011

VL: 25

NO: 6

PG: 746-53

PM: PUBMED 21394118

PT: Journal Article; Randomized Controlled Trial

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/300/CN-00801300/frame.html

KY: Chronic Disease; Dacryocystitis [drug therapy] []; Dacryocystorhinostomy [methods]; ; Epithelium [pathology]; Follow-Up Studies; Hyaluronic Acid [therapeutic use]; Metronidazole [pharmacokinetics] [pharmacology]; Nasal Mucosa [pathology]; Wound Healing [drug effects]; Adult; Female; Humans; Male; Middle Aged

AB: PURPOSE: To investigate the effects of Merogel coverage on ostial patency in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic dacryocystitis (PCD).METHODS: In all, 260 patients with unilateral PCD were randomized into two groups: the Merogel group and the control group. All patients underwent EES-DCR. The Merogel group received Merogel covering the wound 1-2 mm around the ostium and the control group received no treatment. Patients were followed up for 9 months. The mucosal epithelialization of the wound, the proliferation of fibrosis tissue, and the success rate of ostial patency were compared.RESULTS: Our study included 112 patients in the Merogel group and 115 patients in the control group. At the 2-week review, intact mucosal epithelium lined the ostia in 96 Merogel patients compared with 80 control patients (ITT analysis: χ(2)=4.502, P=0.034). At the 9- month review, scars were present in 18 patients in the Merogel group compared with 39 patients in the control group (ITT analysis: χ(2)=9.909, P=0.002, ITT analysis). No differences were observed in the granulation formation between the two groups. The success rate of ostial patency reached 94.6% (106/112) in the Merogel group compared with 80% (92/115) in the control group (ITT analysis: χ(2)=4.151, P=0.042).CONCLUSION: Merogel coverage may enhance the success rate of EES-DCR for PCD by promoting mucosal epithelial healing and preventing excessive scarring.

Record #2 of 15

ID: CN-00778619

AU: Tirakunwichcha S

AU: Aeumjaturapat S

AU: Sinprajakphon S

TI: Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy.

SO: The Laryngoscope

YR: 2011

VL: 121

NO: 2

PG: 433-6

PM: PUBMED 21271601

PT: Journal Article; Randomized Controlled Trial

AD: Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/619/CN-00778619/frame.html

KY: Dacryocystorhinostomy [methods]; Endoscopy; Follow-Up Studies; Intraoperative Period; Lacrimal Duct Obstruction [surgery]; Mitomycin [therapeutic use]; Nasolacrimal Duct [surgery]; Adult; Female; Humans; Male

AB: OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of intraoperative mitomycin C (MMC) in endonasal endoscopic dacryocystorhinostomy.STUDY DESIGN: Randomized controlled trial.METHODS: Fifty patients with primary acquired nasolacrimal duct obstruction were enrolled and randomly allocated into the treatment and control group. The patients underwent standard endonasal endoscopic dacryocystorhinostomy with mucosal flaps and mitomycin C or placebo on each group. The ostium size was measured at 3 months, 6 months, and 12 months to evaluate the effect of mitomycin C and placebo, and the patency of the lacrimal drainage system was assessed.RESULTS: There was no statistical significance in the success rate between the MMC group and the control group at 1-year follow-up (84.6% vs.79.2%, respectively, P = .59). At the 6-month and 12-month visits, the mean ostium size in the MMC group was 10.8 mm(2) (SD = 3.17) and 3.0 mm(2) (SD = 1.78), respectively, which were prominently larger than the control group at 7.1 mm(2) (SD = 2.62; P < .001, 95% CI, 0.84-5.45) and 1.6 mm(2) (SD = 1.18; P = .004, 95% CI, 0.49-2.38).CONCLUSIONS: There was no statistically significant difference in the success rates of both groups, but MMC seems to have a conspicuous effect on the healing process at the ostium.

Record #3 of 15

ID: CN-00811598

AU: Ragab SM

AU: el-Koddousy MS

AU: Badr M

TI: Endocanalicular, high-pressure balloon catheter, endoscopic dacryocystorhinostomy: a randomized controlled trial.

SO: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology- Head and Neck Surgery

YR: 2011

VL: 145

NO: 4

PG: 683-8

PM: PUBMED 21613626

PT: Journal Article; Randomized Controlled Trial

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/598/CN-00811598/frame.html

KY: Balloon Dilation [methods]; Dacryocystorhinostomy [methods]; Endoscopes; Endoscopy [instrumentation] [methods]; Equipment Design; Lacrimal Duct Obstruction [therapy]; Nasolacrimal Duct; Prospective Studies; Adult; Female; Humans; Male; Middle Aged; Young Adult AB: OBJECTIVES: To conduct a prospective randomized controlled study to investigate the safety and efficacy of endocanalicular, high-pressure, 5-mm balloon catheter, endoscopic dacryocystorhinostomy (DCR) in adult patients with acquired complete nasolacrimal obstruction.STUDY DESIGN: Prospective randomized controlled study.SETTING: General hospital.SUBJECTS AND METHODS: Sixty-six adult patients with a total of 70 procedures were recruited to undergo endoscopic DCR. They were prospectively, equally randomized into 2 groups: endocanalicular, high-pressure, 5-mm balloon catheter, endoscopic DCR (group I) and conventional endoscopic DCR (group II). Regular follow-up sessions were conducted to document the patient's subjective improvement, judge ostium patency on irrigation, and record any complications.RESULTS: Both groups demonstrated a success rate of 91.4%. There was a shorter mean operative time (25.7 minutes) in group I (P < .001). The number of adverse events was significantly higher in group II (P < .05). Group I showed statistically significantly more comfort during surgery under local anesthesia with minimal sedation (P < .05).CONCLUSION: Endocanalicular balloon catheter endoscopic DCR shares the advantages and success rate of conventional endoscopic DCR. In addition, the former is simpler, requires less manipulation, consumes a shorter operative time, has a better safety profile, and can be conducted under local anesthesia with minimal sedation.

Record #4 of 15

ID: CN-00812568

AU: Basmak H

AU: Cakli H

AU: Sahin A

AU: Gursoy H

AU: Ozer A

AU: Colak E

TI: What is the role of partial middle turbinectomy in endocanalicular laser-assisted endonasal dacryocystorhinostomy?

SO: American journal of rhinology & allergy

YR: 2011

VL: 25

NO: 4

PG: e160-5 PM: PUBMED 21333092

PT: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/568/CN-00812568/frame.html

KY: Dacryocystorhinostomy; Follow-Up Studies; Lacrimal Apparatus [metabolism] [pathology] [surgery]; Lacrimal Apparatus Diseases [diagnosis] [pathology] [physiopathology] [surgery]; Lasers [utilization]; Nasolacrimal Duct [pathology] [surgery]; Prospective Studies; Recovery of Function; Turbinates [pathology] [surgery]; Adult; Aged; Female; Humans; Male; Middle Aged

AB: BACKGROUND: This study was designed to compare outcomes of endocanalicular laser-assisted endonasal dacryocystorhinostomy (DCR) with and without partial anterior middle turbinectomy.METHODS: A prospective randomized comparative study was conducted on 91 subjects with primary acquired nasolacrimal duct obstruction, undergoing endocanalicular (ECL) procedures. Group 1 was composed of 44 (7 bilateral) patients undergoing ECL diode laser-assisted endonasal DCR without partial anterior middle turbinectomy and group 2 was composed of 47 (7 bilateral) patients undergoing partial anterior middle turbinectomy and ECL diode laser-assisted endonasal DCR. Follow-up period was 11.0 (6.0-14.5 months) months for group 1 and 9.2 (5.0-14.2 months) months for group 2. Functional success was defined as absence of epiphora and anatomic success was defined as ability to irrigate the lacrimal system. Anatomic and functional success at the 1st week, 3rd month, and final postoperative examinations of two groups were compared using chi-square tests.RESULTS: Final anatomic successes were 39/51 (76%) cases for group 1 and 51/54 (94%) cases for group 2. Final functional successes were 36/51 (%71) patients in group 1 and 48/54 (88%) patients in group 2. Group 2 had higher success at the final examination and the difference was statistically significant.CONCLUSION: We recommend partial anterior middle turbinectomy in all laser ECL laser-assisted endonasal DCR, but further studies with larger sample sizes are needed to strengthen our hypothesis.

Record #5 of 15

ID: CN-00751534

AU: Kashkouli MB

AU: Pakdel F

AU: Hashemi M

AU: Ghaempanah MJ

AU: Rezaee R

AU: Kaghaz-Kanani R

AU: Ahadian A TI: Comparing anatomical pattern of topical anti-glaucoma medications associated lacrimal obstruction with a control group.

SO: Orbit (Amsterdam, Netherlands)

YR: 2010

VL: 29

NO: 2

PG: 65-9

PM: PUBMED 20394542

PT: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

AD: Iran University Eye Research Center, Rassoul Akram Hospital, Tehran, Iran. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/534/CN-00751534/frame.html

KY: Administration, Topical; Adolescent; Antihypertensive Agents [adverse effects]; Cross-Sectional Studies; Glaucoma [drug therapy]; Lacrimal Duct Obstruction [chemically induced] [diagnosis]; Nasolacrimal Duct [drug effects] [pathology]; Ophthalmic Solutions [adverse effects]; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Young Adult

CC: SR-EYES

AB: PURPOSE: To compare the anatomical pattern of lacrimal drainage system obstruction (LDSO) associated with topical anti-glaucoma medications (AGM) with a control group.METHODS: In a cross- sectional controlled study, case group included patients on topical anti-glaucoma medications and control group included patients with no history of glaucoma, free of ocular disease, and not using topical medications. Data recording, eye examination, and categorization of patients into case and control groups were performed by a senior ophthalmology resident. Diagnostic probing and irrigation test was performed by an oculoplastic surgeon who was masked to the patients' data. Chi-square (X(2)) and tests were used to assess the effect of sex and systemic diseases, as well as logistic regression analysis with intra-cluster correlation for the effect of topical anti-glaucoma medications on lacrimal drainage system, and then independent sample t-tests to compare the mean ages, plus the binary logistic regression test for the effect of increasing age on LDSO.RESULTS: There were 128 eyes of 96 patients in the case and 277 eyes of 172 patients in the control group. Two groups were similar regarding to the age, sex, and associated systemic disorders (0.3

Record #6 of 15

ID: CN-00750498

AU: Komínek P

AU: Cervenka S

AU: Matousek P

TI: Does the length of affect the success of treatment for congenital nasolacrimal duct obstruction?

SO: Ophthalmic plastic and reconstructive surgery

YR: 2010

VL: 26

NO: 2

PG: 103-5

PM: PUBMED 20305509

PT: Comparative Study; Journal Article; Randomized Controlled Trial

AD: Department of Otolaryngology, University Hospital Ostrava, Czech Republic. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/498/CN-00750498/frame.html

KY: Fluorescein [metabolism]; Fluorescent Dyes [metabolism]; Intubation [instrumentation] [methods]; Lacrimal Duct Obstruction [congenital] [metabolism] [therapy]; Nasolacrimal Duct; Prospective Studies; Silicones; Stents; Time Factors; Treatment Outcome; Child, Preschool; Humans; Infant

CC: SR-EYES

AB: PURPOSE: To compare success rates of intubation for 2 versus 5 months in congenital nasolacrimal duct obstruction in children between 15 and 30 months of age.METHODS: This prospective, randomized study evaluated drainage function in 145 eyes of children aged between 15 and 30 months and treated for congenital nasolacrimal duct obstruction using silicone stents with the fluorescein dye disappearance test. The tubes were removed 2 months (group I, 48 eyes) and 5 months (group II, 47 eyes) after stent placement. Thereafter, the children were followed for 6 months after tube removal. Fifty eyes were excluded from the study because of incomplete follow-up.RESULTS: The full resolution of symptoms (fluorescein test 0-1) was 33 of 48 in group I and 33 of 47 in group II at the time of tube removal (2 vs. 5 months). Six months after tube removal, the success rate was 43 of 48 (89.6%) in group I and 43 of 47 (91.5%) in group II. After the stents were removed, no relapses were observed in children having a fluorescein test 0-1 with the tubes remaining in the lacrimal system.CONCLUSIONS: The effects of intubation for 2 versus 5 months on the function of the nasolacrimal duct during and after intubation in children between 15 and 30 months of age are comparable. The fluorescein dye disappearance test is the test of choice for monitoring lacrimal drainage function.

Record #7 of 15

ID: CN-00749084

AU: Naiboglu B

AU: Deveci I

AU: Kalaycik C

AU: Daylan A

AU: Habesoglu TE

AU: Toros SZ

AU: Deveci SE

AU: Egeli E

TI: Effect of nasolacrimal duct obstruction on nasal mucociliary transport.

SO: The Journal of laryngology and otology

YR: 2010

VL: 124

NO: 2

PG: 166-70

PM: PUBMED 19874638

PT: Journal Article; Randomized Controlled Trial

AD: Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/084/CN-00749084/frame.html KY: Fluorescein [diagnostic use]; Lacrimal Duct Obstruction [diagnosis] [etiology] [physiopathology]; Mucociliary Clearance [physiology]; Prospective Studies; Saccharin [diagnostic use]; Time Factors; Adult; Female; Humans; Male; Middle Aged

AB: BACKGROUND: Most patients with nasolacrimal duct obstruction have dry, crusty nasal mucosa. Mucociliary clearance is modulated by the amount and biochemical composition of nasal mucus. Nasolacrimal duct obstruction disturbs the drainage of tears into the nasal cavity.OBJECTIVE: We examined the effect of nasolacrimal duct obstruction on the mucociliary transport of nasal mucosa, by comparing saccharine test results for epiphora patients versus healthy volunteers.STUDY DESIGN: Prospective, randomised, clinical trial.METHODS: Eight patients with bilateral epiphora and 10 patients with unilateral epiphora were included in the study group. Complete nasolacrimal duct obstruction was demonstrated by studying irrigation of the nasolacrimal system, and by fluorescein dye study. The control group comprised 20 healthy volunteers. Mucociliary transport was assessed by the saccharine test in both the study and control groups. The saccharine transit times of 26 impaired nasal cavities were compared with those of 20 healthy nasal cavities of controls. Also, the saccharine transit times of the healthy nasal cavities of the 10 patients with unilateral epiphora were compared with those of their diseased sides, and also with those of healthy volunteers.RESULTS: The saccharine transit times of the epiphora patients were statistically significantly greater than those of the control group. Also, there was a statistically significant difference in saccharine transit times, comparing the healthy and impaired nasal cavities of patients with unilateral epiphora.CONCLUSION: Nasolacrimal duct obstruction has a negative effect on nasal mucociliary clearance. This may be related to changes in the amount and biochemical composition of nasal mucus.

Record #8 of 15

ID: CN-00768035

AU: Javate RM

AU: Pamintuan FG

AU: Cruz RT

TI: Efficacy of endoscopic lacrimal duct recanalization using microendoscope.

SO: Ophthalmic plastic and reconstructive surgery

YR: 2010

VL: 26

NO: 5

PG: 330-3 PM: PUBMED 20592632

PT: Comparative Study; Journal Article; Randomized Controlled Trial

AD: Department of Ophthalmology, University of Santo Tomas Hospital, University of Santo Tomas, Sampaloc, Manila, Philippines. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/035/CN-00768035/frame.html

KY: Dacryocystorhinostomy [methods]; Endoscopes; Endoscopy [instrumentation] [methods]; Follow-Up Studies; Lacrimal Duct Obstruction [metabolism] [physiopathology] [surgery]; Nasolacrimal Duct [physiopathology] [surgery]; Prospective Studies; Tears [secretion]; Treatment Outcome; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged

AB: PURPOSE: To describe a new endoscopic procedure to restore the passage of tears in an obstructed lacrimal drainage system and to compare its efficacy with the standard external dacryocystorhinostomy (SE-DCR).METHODS: Patients with complete and partial primary acquired nasolacrimal duct obstruction (PANDO) were randomly allocated to 2 treatment groups using completely randomized design. The first group was treated using endoscopic lacrimal duct recanalization (ELDR), while the second group was treated using SE-DCR. Follow-up was conducted for at least 6 months and evaluated for anatomical and functional patency. Complications were also noted for both groups.RESULTS: A total of 86 patients underwent ELDR, 60 of whom had complete PANDO, while 26 patients had partial PANDO. Eighty patients underwent SE-DCR; 58 had complete PANDO, and 22 had partial PANDO. The combined success rate in terms of anatomical patency for ELDR was 93.02% (95% confidence interval [CI], 0.88-98) compared with 93.75% (95% CI, 0.87-90) for SE-DCR (p = 0.85). Meanwhile, the combined success rate (functional patency) for ELDR is 84.88% (95% CI, 0.77-93) versus 90.00% (95% CI, 0.83-97) for SE-DCR (p = 0.32).CONCLUSIONS: ELDR using microendoscope is as efficacious as SE-DCR, without its associated major complications.

Record #9 of 15

ID: CN-00772297

AU: Andalib D

AU: Gharabaghi D

AU: Nabai R

AU: Abbaszadeh M

TI: Monocanalicular versus bicanalicular silicone intubation for congenital nasolacrimal duct obstruction.

SO: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus YR: 2010

VL: 14

NO: 5

PG: 421-4

PM: PUBMED 21035069

PT: Comparative Study; Journal Article; Randomized Controlled Trial

AD: Strabismus and Oculoplastic Unit, Nikookary Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/297/CN-00772297/frame.html

KY: Anesthesia; Device Removal; Intubation [instrumentation] [methods]; Lacrimal Duct Obstruction [congenital] [therapy]; Nasolacrimal Duct; Outpatients; Silicones; Stents; Treatment Outcome; Child; Child, Preschool; Humans; Infant

CC: SR-EYES

AB: PURPOSE: To compare the success rate of monocanalicular versus bicanalicular silicone intubation of the nasolacrimal duct for congenital nasolacrimal duct obstruction (CNLDO).METHODS: In a prospective randomized clinical trial, 70 eyes of 57 children with CNLDO underwent either monocanalicular silicone intubation (MCI) (n = 35 eyes) or bicanalicular silicone intubation (BCI) (n = 35 eyes). All procedures were performed by 1 oculoplastic surgeon. Tube removal was planned for 3 months postoperatively. The results were assessed using a Munk score. Treatment success was defined as Munk score 0-1 at 3 months after tube removal.RESULTS: The surgical outcome was assessed in 29 eyes with MCI and 27 eyes with BCI. The mean age of treatment was 34.9 ± 12.7 months for MCI and 38.7 ± 18.6 months for BCI. Treatment success was achieved in 25 of 29 eyes (86.2%; 95% CI, 79%-96%) in the MCI group compared with 24 of 27 eyes (89%; 95% CI, 84%-94%) in the BCI group (RR = 0.96; 95% CI, 0.79-1.18). There were no corneal or canalicular complications in either group.CONCLUSIONS: MCI and BCI were successful in a similar percentage of children with CNLDO. The mainadvantage of the former technique was easy tube removal without sedation in the office.

Record #10 of 15

ID: CN-00803597

AU: Liu H-F

AU: Zheng A-Z AU: Chen Z-L

TI: [Observation on curative effect of double-flap or single-flap anastomosis in two different external dacryocystorhinostomy methods] LA: Chi

SO: International Journal of Ophthalmology

YR: 2010

VL: 10

NO: 5

PG: 1007-8

XR: EMBASE 2010309422

DE: RCT PT: Journal: Article

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/597/CN-00803597/frame.html

KY: *Anastomosis; Article; Comparative Study; *Dacryocystorhinostomy; *Double Flap Anastomosis; Eye; Follow up; Human; Major Clinical Study; Observational Study; *Single Flap Anastomosis; Suturing Method; Therapy Effect; Treatment Outcome

AB: AIM: To compare the curative effect of the external dacryocystorhinostomy (DCR), using two different patterns of flap anastomosis with suturing of two flaps or anterior flap. METHODS: Fifty-six eyes 48 patients were randomized and assigned to two groups on the basis of the pattern of flap anastomosis. In double-flap group with 25 eyes 20 patients, posterior and anterior flaps were separately sutured. In single-flap group with 31 eyes 28 patients, only the anterior flaps were sutured after resecting of both posterior flaps. RESULTS: The time of follow-up was 6-10 months for all patients. The final success rates in double-flap groups were 92% and in single-flap group were 90% respectively. There was no significant statistical difference in success rate between the groups. CONCLUSION: DCR with double-flap anastomosis has no advantage over only anterior flap. Anastomosis by only anterior flap and resected posterior flap is easier to perform and does not appear adversely to affect the outcome of DCR surgery.

Record #11 of 15

ID: CN-00778494

AU: Choontanom R

TI: Probing and syringing with 3% solution of NaCl and/or 0.2 mg/ml mitomycin-C in nasolacrimal duct obstruction patients. SO: Journal of the Medical Association of Thailand = Chotmaihet thangphaet

YR: 2010

VL: 93 Suppl 6

PG: S197-202

PM: PUBMED 21280534

PT: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

AD: Department of Ophthalmology, Phramongkutklao College of Medicine, Bangkok, Thailand. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/494/CN-00778494/frame.html

KY: Antibiotics, Antineoplastic [administration & dosage]; Lacrimal Duct Obstruction [therapy]; Mitomycin [administration & dosage]; Nasolacrimal Duct [surgery]; Pain Measurement; Prospective Studies; Sodium Chloride [therapeutic use]; Syringes; Therapeutic Irrigation [methods]; Treatment Outcome; Adult; Aged; Female; Humans; Male; Middle Aged

CC: SR-EYES

AB: OBJECTIVE: To compare the efficacy of lacrimal probing and syringing among 3% solution of Sodium Chloride and/or 0.2 mg/ ml Mitomycin-C as an adjunctive medication.DESIGN: A prospective, randomized, 2 by 2 factorial design study.MATERIAL AND METHOD: Forty-eight of nasolacrimal duct obstruction patients with epiphora symptom were randomly assigned to receive either Normal Saline Solution or 3% solution of Sodium Chloride or 0.2 mg/ml Mitomycin-C solution or combined 3% solution of Sodium Chloride with 0.2 mg/ml Mitomycin-C solution, during office probing and syringing. The intervention was performed repeatedly at week 0, weeks 2 and 4. An assessment of epiphora with Visual Analogue Scale were evaluated at week 0, weeks 2, 4, 8 and 12.RESULTS: Probing and syringing was successfully reducing epiphora symptom. Mitomycin-C group showed a significant reduction in mean difference of Visual Analogue Scale score compared with Normal Saline Solution group (2.85, 95% CI: 1.164-4.536, p < 0.001) and 3% Sodium Chloride group (2.175, 95% CI: 0.489-3.861, p < 0.01). No complication or adverse event was found.CONCLUSION: 0.2 mg/ml Mitomycin-C solution of was the most effective medication for office probing and syringing in reducing epiphora symptom in nasolacrimal duct obstruction patients.

Record #12 of 15

ID: CN-00803573

AU: Li L-C AU: Ouyang L

AU: Li D-J

AU: Huang Q

TI: [Ring silicone tube implantation combined with mitomycin C for the treatment of upper lacrimal duct obstruction] LA: Chi

SO: International Journal of Ophthalmology

YR: 2010

VL: 10

NO: 1

PG: 187-8

XR: EMBASE 2010094435

DE: RCT PT: Journal: Article

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/573/CN-00803573/frame.html

KY: Article; Controlled Study; Drug Effect; Extubation; ; Human; *Lacrimal Duct Occlusion; Dt [Drug Therapy]; *Lacrimal Duct Occlusion; Su [Surgery]; Major Clinical Study; Silastic Tube; *Mitomycin C; Dt [Drug Therapy]

AB: AIM: To study the effect of ring silicone tube implantation combined with mitomycin C for the treatment of upper lacrimal duct obstruction. METHODS: Eighty-nine cases (116 eyes) with upper lacrimal duct obstruction underwent the procedure of intubation in outpatient clinic: tears points obstruction(14 eyes), lacrimal duct obstruction (38 eyes), tears explorer obstruction (64 eyes). The patients were randomly divided into 2 groups. Group A consisted of 44 cases (58 eyes): tears points obstruction (6 eyes), lacrimal duct obstruction (20 eyes), nasolacrimal duct obstruction (32 eyes). Group B consisted of 45 cases (58 eyes): tears points obstruction(8 eyes), lacrimal duct obstruction(18 eyes), nasolacrimal duct obstruction (32 eyes). The materials were silicone tube, duct expansion wire which was made by myself. Two-canalicular-nasolacri-mal duct were installed ring silicone tube. The time of extubation was after 3-6 months. If the patients were also with nasolacrimal duct obstruction, inverse ball silicone tube implantation in nasolacrimal canal should be performed immediately after the extubation of the ring silicone tube. What group B distinguished from group A was indwelling duct expansion wire which is immersed in 0. 25mg/mL mitomycin C for 3-5 minutes, lacrimal duct was washed regularly after extubation of ring silicone tube, and the patients were followed up for 2 years. RESULTS: The cure rate of group A was 72. 4%, the cure rate of group B was 93. 1%. There were significant differences in recovery rate between the two groups(P < 0. 01). CONCLUSION: The method of installing ring silicone tube under mitomycin C can improve the success rate of surgery and can be a better way to cure upper lacrimal duct obstruction.

Record #13 of 15

ID: CN-00748445

AU: Elmorsy S

AU: Fayek HM

TI: Rubber tube versus silicone tube at the osteotomy site in external dacryocystorhinostomy.

SO: Orbit (Amsterdam, Netherlands)

YR: 2010

VL: 29

NO: 2

PG: 76-82

PM: PUBMED 20394544

PT: Comparative Study; Journal Article; Randomized Controlled Trial

AD: ENT Department, Mansoura University, Egypt. [email protected]

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/445/CN-00748445/frame.html

KY: Dacryocystorhinostomy [instrumentation] [methods]; Intubation; Lacrimal Duct Obstruction [surgery]; Nasolacrimal Duct [surgery]; Osteotomy; Prospective Studies; Rubber; Silicone Elastomers; Stents; Treatment Outcome; Adult; Female; Humans; Male; Middle Aged

CC: SR-EYES

AB: BACKGROUND: In external dacryocystorhinostomy a large bony window is created in the lateral nasal wall and a mucosal anastomosis is created between the lacrimal sac and the nasal cavity. The success of the operation depends on the surgical anastomosis remains patent and converting to a wide enough epithelial-lined passage.OBJECTIVE: To compare the efficacy of using rubber versus silicone tubes at the osteotomy of Dacryocystorhinostomy.DESIGN: Prospective, randomized, hospital-based study.SUBJECTS AND METHODS: 46 patients diagnosed with primary acquired nasolacrimal duct obstruction were assigned randomly to rubber, silicone or control group. The surgical procedures in the three groups were the same except that in patients of rubber and silicone groups, rubber or silicone tubes were placed at osteotomy opening and removed after 3 months. Transnasal endoscopic findings were recorded at the completion of surgery and at 3 months, 6 months and 9 monthes after surgery for the 3 groups. A computer aided digitizer was used to calculate the surface area of the osteotomy site. Results: After removal of their tubes, 3 patients in the rubber group had recurrent epiphora (78.0% success), one patient in silicone group (92.86% success) and 4 patients in control group (77.8% success). The average final surface area of the osteotomy opening of patients with rubber group at the end of follow-up was (9.85 mm(2)) in the silicone group was (17.47 mm(2)), whereas in the control group was (8.56 mm(2)).CONCLUSION: Silicone tube is better than rubber one in maintaining effective larger osteotomy after Dacryocystorhinostomy. This can improve the long-term success of the operation.

Record #14 of 15

ID: CN-00772991

AU: Chen F

AU: Wang J

AU: Chen W

AU: Shen M

AU: Xu S

AU: Lu F

TI: Upper punctal occlusion versus lower punctal occlusion in dry eye.

SO: Investigative ophthalmology & visual science

YR: 2010

VL: 51

NO: 11

PG: 5571-7

PM: PUBMED 20463310

PT: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

AD: School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China.

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/991/CN-00772991/frame.html

KY: Collagen; Cornea [physiology]; Dry Eye Syndromes [physiopathology]; Eyelids [physiopathology]; Fluorophotometry; Lacrimal Duct Obstruction [physiopathology]; Prospective Studies; Prostheses and Implants; Questionnaires; Tears [chemistry]; Tomography, Optical Coherence; Female; Humans; Male; Young Adult

CC: SR-EYES

AB: PURPOSE: To compare the effectiveness of upper punctal occlusion versus that of lower punctal occlusion in dry eye patients.METHODS: One eye's upper punctum and the contralateral eye's lower punctum were occluded with collagen plugs in 20 dry eye patients. The same procedure was performed in 20 normal subjects. The upper and lower tear menisci were imaged simultaneously by real-time OCT before punctal occlusion and repeated on days 1, 4, 7, and 10 afterward. The subjective symptom score, corneal fluorescein staining intensity, Schirmer I test result, and tear breakup time (TBUT) were also determined.RESULTS: In dry eye patients, occlusion of either punctum improved symptom scores, fluorescein staining scores, TBUT, and lower tear meniscus height (LTMH, P < 0.05); however, Schirmer test scores and upper tear meniscus height (UTMH) did not change after occlusion (P > 0.05). There was no significant difference for any of these variables between upper punctum- and lower punctum- occluded eyes, before or after occlusion (P > 0.05). In normal subjects, Schirmer test scores, TBUT, UTMH, and LTMH did not change over time (P > 0.05).CONCLUSIONS: Punctal occlusion with collagen plugs in dry eye patients leads to the relief of subjective symptoms and the improvement of objective signs. The effectiveness of occluding the upper or lower punctum is similar. The LTMH is a valid indicator of the success of punctal occlusion.

Record #15 of 15

ID: CN-00766972

AU: Gock G

TI: Use of mitomycin C to improve endonasal dacryocystorhinostomy (DCR) success rates

SO: ICTRP [accessed 14 Oct 2010]

YR: 2010

PG: ID: ISRCTN15566163

DE: RCT

UF: http://www.controlled-trials.com/ISRCTN15566163

US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/972/CN-00766972/frame.html

CC: SR-ENT; SR-EYES

PMID- 22732136 OWN - NLM

STAT- Publisher

DA - 20120626

IS - 1945-8932 (Electronic)

IS - 1945-8932 (Linking)

DP - 2012 Jun 21

TI - Primary endoscopic dacryocystorhinostomy with or without silicone tubing: A

prospective randomized study.

AB - BACKGROUND: Endoscopic dacryocystorhinostomy (DCR) is an effective surgical

procedure to treat saccal and postsaccal stenosis or nasolacrimal duct

obstruction. The use of silicone tube after endoscopic DCR is still

controversial. A prospective randomized study was conducted to compare the

success rate between the use of silicone stent and no use of silicone stent in

endoscopic DCR.METHODS: A prospective randomized study was conducted at Aseer

Central Hospital and Abha Private Hospital, Abha, Kingdom of Saudi Arabia, on

allpatients undergoing endoscopic DCR between July 1, 2006 and 30 June 30, 2010.

Patients were allocated randomly for endoscopic DCR with or without stent. The

data collection included age, sex, diagnosis, method, and duration of surgery.

Patients were followed up postoperatively at 1 week, 1 month, and then every 3

months for 1 year.RESULTS: During the period of the study a total of 173 cases of

postsaccal stenosis underwent endoscopic DCR (67 male and 106 female subjects).

The meanage was 51.8 years (range, 18-72 years). A stent was used in 92 patients

(53.2%) and not used in 81 patients (46.8%). With silicone tubing the success

rate was 96%, and without silicone tubing it was 91%, an overall success rate of

94%. The odds ratio of failure without a silicone tube was 3.25 but confidence interval was from 0.84 to 12.60 and the difference between these two groups was

statistically not significant (p = 0.117).CONCLUSION: In this study, there was no

statistically significant advantage of using endoscopic DCR with stent over the

endoscopic DCR without stent.

AU - Qahtani AS

LA - ENG

PT - JOURNAL ARTICLE

DEP - 20120621

TA - Am J Rhinol Allergy

JT - American journal of rhinology & allergy

JID - 101490775

EDAT- 2012/06/27 06:00

MHDA- 2012/06/27 06:00

CRDT- 2012/06/27 06:00

AID - 3789 [pii]

AID - 10.2500/ajra.2012.26.3789 [doi]

PST - aheadofprint

SO - Am J Rhinol Allergy. 2012 Jun 21.

PMID- 22384944

OWN - NLM

STAT- In-Process

DA - 20120515

IS - 1651-2251 (Electronic)

IS - 0001-6489 (Linking) VI - 132 Suppl 1

DP - 2012 Jun

TI - Endoscopic dacryocystorhinostomy without silicone stent.

PG - S77-81

AB - CONCLUSION: In nasolacrimal duct (NLD) obstruction patients that undergo

endoscopic dacryocystorhinostomy (DCR), creation of a patent rhinostomy with

adequate epithelialization can be accomplished without a stent. However, in

common canalicular obstruction patients, a silicone stent seems to have a

beneficial role and to bear more favorable results. OBJECTIVES: The aim of this

study was to evaluate the surgical outcome of endoscopic DCR without the use of a

silicone stent. METHODS: In all, 36 patients (41 eyes) who underwent endoscopic

DCR were enrolled in this study. The patients were classified into a DCR with

silicone stent group and a DCR without silicone stent group. Then each of the

groups was subdivided into common canalicular obstruction group and NLD

obstruction group. Surgical outcomes were evaluated by postoperative symptom

improvement and patency of the rhinostomy under nasal endoscopic exam. RESULTS:

The epiphora was improved in 84.2% of the silicone stent group and 81.8% of the

non-silicone stent group. Categorized by the level of obstruction, in common

canalicular obstruction, the success rate was 84.5% (11/13) in the silicone stent

group and 57.1% (4/7) in the no stent group. In NLD obstruction, the success rate

was 83.0% (5/6) in the silicone stent group and 93.3% (14/15) in the no stent

group.

AD - Department of Otorhinolaryngology - Head and Neck Surgery, Chungbuk National

University, Cheongju, Korea.

FAU - Yeon, Je Yeob AU - Yeon JY

FAU - Shim, Woo Sub

AU - Shim WS

LA - eng

PT - Journal Article

PT - Research Support, Non-U.S. Gov't

DEP - 20120304

PL - England

TA - Acta Otolaryngol

JT - Acta oto-laryngologica

JID - 0370354

SB - IM

EDAT- 2012/03/06 06:00

MHDA- 2012/03/06 06:00

CRDT- 2012/03/06 06:00

PHST- 2012/03/04 [aheadofprint]

AID - 10.3109/00016489.2012.659754 [doi]

PST - ppublish

SO - Acta Otolaryngol. 2012 Jun;132 Suppl 1:S77-81. Epub 2012 Mar 4.

PMID- 22551366

OWN - NLM

STAT- MEDLINE

DA - 20120503

DCOM- 20120622 IS - 1744-5108 (Electronic)

IS - 0167-6830 (Linking)

VI - 31

IP - 3

DP - 2012 Jun

TI - A cadaveric study of the morphometric relationships and bony composition of the

caucasian nasolacrimal fossa.

PG - 159-61

AB - AIMS: To describe the morphometric relationships and bony composition of the

nasolacrimal fossa in a Caucasian population with particular reference to the

lacrimo-maxillary suture (LMS). METHODS: Forty-seven orbits from 24 formalin

fixed cadavers were exenterated. Morphometric measurements were taken between

anatomical landmarks forming the lacrimal fossa on the medial orbital wall.

RESULTS: The mean recorded distance from the anterior lacrimal crest (ALC) to the

posterior lacrimal crest (PLC) and the LMS were 8.8 mm (+/- 1.6) and 4.3 mm (+/-

1.1), respectively. In 25.5% of the orbits the LMS was at the mid-vertical line

(MVL), defined as a line equidistant from the ALC and PLC. In 42.5% the LMS was

located anterior to the MVL toward the ALC. In 66% of the orbits the LMS was at

or within one standard deviation (SD) of the MVL. The LMS was >1 SD away from the

MVL toward the ALC and PLC in 19% and 15% of orbits, respectively. CONCLUSIONS:

In a quarter of the orbits in our Caucasian population the nasolacrimal fossa was

formed equally by the maxillary and lacrimal bones. However, in nearly a third of

the cases the LMS was located closer to the PLC, indicating predominance of the

thicker maxillary bone. This may result in greater difficulty in initiating the

surgical osteotomy when performing a dacryocystorhinostomy. These data contribute to our understanding of the variation in lacrimal fossa anatomy and encourage

further studies in different racial groups.

AD - Adnexal Service, Moorfields Eye Hospital, London, UK. [email protected]

FAU - Shams, Pari N

AU - Shams PN

FAU - Abed, Saif F

AU - Abed SF

FAU - Shen, Sunny

AU - Shen S

FAU - Adds, Philip J

AU - Adds PJ

FAU - Uddin, Jimmy M

AU - Uddin JM

LA - eng

PT - Journal Article

PL - England

TA - Orbit

JT - Orbit (Amsterdam, Netherlands)

JID - 8301221

SB - IM

MH - Cadaver

MH - *European Continental Ancestry Group

MH - Female

MH - Humans

MH - Male MH - Maxilla/*anatomy & histology

MH - Nasolacrimal Duct/*anatomy & histology

MH - Orbit/*anatomy & histology

EDAT- 2012/05/04 06:00

MHDA- 2012/06/23 06:00

CRDT- 2012/05/04 06:00

AID - 10.3109/01676830.2011.648809 [doi]

PST - ppublish

SO - Orbit. 2012 Jun;31(3):159-61.

PMID- 22645114

OWN - NLM

STAT- Publisher

DA - 20120530

IS - 1097-6817 (Electronic)

IS - 0194-5998 (Linking)

DP - 2012 May 29

TI - Mitomycin C-Enhanced Revision Endoscopic Dacryocystorhinostomy: A Prospective

Randomized Controlled Trial.

AB - Objectives. (1) To conduct an adequately powered randomized controlled trial

investigating the safety and efficacy of mitomycin C-enhanced revision endoscopic

dacryocystorhinostomy (DCR) and (2) to analyze causes of failure after primary

endoscopic DCR.Study Design. A randomized controlled study.Setting. General

hospital.Subjects and Methods. Seventy-six revision endoscopic DCRs were

randomized into 2 groups: endoscopic DCR with mitomycin (group I), where 0.5 mg/mL mitomycin C was applied for 10 minutes, and endoscopic DCR without

mitomycin (group II). Follow-up settings were done to document the patient's

subjective improvement, to judge ostium patency on irrigation, and to record any

complications.Results. Causes of failure in the original 92 patients included

canalicular obstruction (14%), small misplaced bony window (43%), very small

nasolacrimal stoma due to development of synechia (23%), and complete closure of

nasolacrimal stoma with tough fibrous tissue (63%). There was no significant

difference between the 2 groups in subjective and objective success rates and

adverse events. Group I demonstrated a significantly longer operative time and a

significantly lower number of debridement sessions (mean of 1.2 vs

1.9).Conclusions. Recurrent nasolacrimal duct obstruction after primary

endoscopic DCR is mainly due to reclosure of the nasolacrimal stoma with synechia

and fashioning of the small misplaced bony window. Mitomycin C does not increase

the success rate of revision endoscopic DCR. It is a safe procedure and may be of

value only in patients inaccessible to strict follow-up because it induces a

better healing profile in terms of mucosal recovery, wound healing, and less need

for debridement sessions.

AD - Otolaryngology and Head & Neck Surgery, Tanta University Hospitals, Tanta, Egypt.

AU - Ragab SM

AU - Elsherif HS

AU - Shehata EM

AU - Younes A

AU - Gamea AM

LA - ENG

PT - JOURNAL ARTICLE DEP - 20120529

TA - Otolaryngol Head Neck Surg

JT - Otolaryngology--head and neck surgery : official journal of American Academy of

Otolaryngology-Head and Neck Surgery

JID - 8508176

EDAT- 2012/05/31 06:00

MHDA- 2012/05/31 06:00

CRDT- 2012/05/31 06:00

AID - 0194599812450280 [pii]

AID - 10.1177/0194599812450280 [doi]

PST - aheadofprint

SO - Otolaryngol Head Neck Surg. 2012 May 29.

PMID- 22623114

OWN - NLM

STAT- Publisher

DA - 20120524

IS - 1435-702X (Electronic)

IS - 0721-832X (Linking)

DP - 2012 May 24

TI - Success rate and complications of endonasal dacryocystorhinostomy with

unciformectomy.

AB - BACKGROUND: Endonasal dacryocystorhinostomy (DCR) has been widely used to treat

nasolacrimal duct obstruction. Here, we evaluated the anatomical advantages of

the uncinate process as a landmark and to study the effect of unciformectomy on success rate and complications of endonasal DCR . METHODS: In total, 288 eyes of

265 adult patients who underwent endonasal DCR between January 2003 and February

2010 were reviewed retrospectively. The eyes were classified into two groups,

according to whether unciformectomy was performed or not. All surgical procedures

and surgical indications were the same except unciformectomy and endonasal DCR

was performed by one surgeon. Unciformectomy was performed by resecting the

anterior part of uncinate process. RESULTS: One hundred and eighty-six eyes of

168 patients received endonasal DCR with unciformectomy, and 102 eyes of 97

patients received endonasal DCR alone. The average success rate of endonasal DCR

with unciformectomy was 97.8 % and that of endonasal DCR alone was 90.2 %, with

statistically significant difference (Student's t-test, p-value < 0.05). There

were 14 eyes with post-operative nasolacrimal obstruction, caused by granuloma in

five eyes, intranasal synechia in two eyes, membranous obstruction in six eyes,

and canalicular stenosis in one eye. There were no serious complications such as

orbital fat prolapse, cerebrospinal fluid leak, or delayed hemorrhage.

CONCLUSIONS: Anterior resection of the uncinate process gives improved access to

the lacrimal bone by exposing the medial aspect of the lacrimal fossa and forming

the precise location of the osteotomy on the lacrimal bone during endonasal DCR.

Thus, the uncinate process can be used as an anatomical landmark for endonasal

DCR. The unciformian endonasal DCR improves operation success rate by allowing

access to the large space of the nasal cavity and reducing the synechiae of the

nasal cavity.

AD - Department of Ophthalmology, Busan Paik Hospital, Inje University Medical

College, Gaegum-dong, Busanjin-gu, Busan, 633-165, Korea, [email protected].

AU - Yang JW AU - Oh HN

LA - ENG

PT - JOURNAL ARTICLE

DEP - 20120524

TA - Graefes Arch Clin Exp Ophthalmol

JT - Graefe's archive for clinical and experimental ophthalmology = Albrecht von

Graefes Archiv fur klinische und experimentelle Ophthalmologie

JID - 8205248

EDAT- 2012/05/25 06:00

MHDA- 2012/05/25 06:00

CRDT- 2012/05/25 06:00

PHST- 2011/10/08 [received]

PHST- 2012/02/27 [accepted]

PHST- 2012/02/21 [revised]

PHST- 2012/05/24 [aheadofprint]

AID - 10.1007/s00417-012-1992-x [doi]

PST - aheadofprint

SO - Graefes Arch Clin Exp Ophthalmol. 2012 May 24.

PMID- 22581634

OWN - NLM

STAT- Publisher

DA - 20120514

IS - 1097-6817 (Electronic)

IS - 0194-5998 (Linking) DP - 2012 May 11

TI - Endoscopic Dacryocystorhinostomy with Double Posteriorly Based Nasal and Lacrimal

Flaps: A Prospective Randomized Controlled Trial.

AB - Objectives. To conduct the first prospective randomized controlled trial

assessing and comparing the safety and efficacy of endoscopic

dacryocystorhinostomy (DCR) with double posteriorly based nasal and lacrimal

flaps to conventional endoscopic DCR in adult patients with acquired complete

nasolacrimal obstruction.Study Design. A prospective randomized controlled

study.Setting. General hospital.Subjects and Methods. Seventy-four adult patients

with a total of 80 procedures were recruited to undergo endoscopic DCR. They were

prospectively equally randomized into 2 groups: endoscopic DCR with flaps (group

I) and conventional endoscopic DCR (group II). Regular follow-up settings were

done to document the patient's subjective improvement, judge ostium patency on

irrigation, and record any complications.Results. Endoscopic DCR with flaps had a

higher (92.1%) but nonsignificant difference in success rate when compared with

conventional endoscopic DCR (87.4%). There was no significant difference between

the 2 techniques in operative time, adverse events, and tolerability of the

technique to be done under local anesthesia with minimal sedation. Group I

demonstrated a significantly lower number of debridement sessions than did group

II.Conclusion. Endoscopic DCR with double posteriorly based nasal and lacrimal

flaps provides a viable alternative to conventional endoscopic DCR in managing

acquired nasolacrimal duct obstructions in adults. It has a comparable success

rate, operative time, and safety profile, with a suggestion of a better healing

profile in terms of mucosal recovery, wound healing, and less need for

debridement sessions. AD - Department of Otolaryngology and Head & Neck Surgery, Tanta University Hospitals,

Tanta, Egypt.

AU - Khalifa MA

AU - Ragab SM

AU - Saafan ME

AU - El-Guindy AS

LA - ENG

PT - JOURNAL ARTICLE

DEP - 20120511

TA - Otolaryngol Head Neck Surg

JT - Otolaryngology--head and neck surgery : official journal of American Academy of

Otolaryngology-Head and Neck Surgery

JID - 8508176

EDAT- 2012/05/15 06:00

MHDA- 2012/05/15 06:00

CRDT- 2012/05/15 06:00

AID - 0194599812447759 [pii]

AID - 10.1177/0194599812447759 [doi]

PST - aheadofprint

SO - Otolaryngol Head Neck Surg. 2012 May 11.

PMID- 22566177

OWN - NLM

STAT- Publisher

DA - 20120508 IS - 1434-4726 (Electronic)

IS - 0937-4477 (Linking)

DP - 2012 May 8

TI - Surgical success rate comparison in functional nasolacrimal duct obstruction:

simple lacrimal stent versus endoscopic versus external dacryocystorhinostomy.

AB - Silicone tube intubation (STI) has been known as a standard treatment modality

with functional nasolacrimal duct obstruction (FNDO). Recently,

dacryocystorhinostomy (DCR) is suggested for FNDO treatment. However, there are

no data for comparison according to the surgical types in FNDO patients. This

study aimed to compare success rates of three different lacrimal drainage

in FNDO patients. Consecutive patients (153 eyes) who were treated with

surgical intervention due to FNDO were analyzed. Patients were divided into three

groups according to the type of surgery undertaken: STI, endoscopic DCR

(Endo-DCR), and external DCR (Ext-DCR). Symptomatic improvements in epiphora were

evaluated using the following scoring system: 1, complete resolution (indicative

of success); 2, partial resolution; and 3, no resolution or worsening of the

condition. At months 3 and 6, the Endo-DCR group had the highest success rate

(84.4 and 81.3 %), but there were no statistically significant differences in

epiphora scoring among the patients. Epiphora was significantly improved after

surgery by week 2 in the Endo-DCR group (p = 0.0339) and by week 3 in the STI

group (p = 0.0161). There were no patients in the Endo- or Ext-DCR group with a

score of 3 at month 6, but 4 of 6 (3.7 %) in the STI group had score of 3 at

month 6 and underwent additional DCR for epiphora. Our results suggest that

Endo-DCR offers the highest success rates in FNDO treatments in terms of the

rapid and complete resolution of epiphora. AD - Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The

Catholic University of Korea, #505, Banpo-dong, Seocho-gu, Seoul, 137-701, Korea.

AU - Cho WK

AU - Paik JS

AU - Yang SW

LA - ENG

PT - JOURNAL ARTICLE

DEP - 20120508

TA - Eur Arch Otorhinolaryngol

JT - European archives of oto-rhino-laryngology : official journal of the European

Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the

German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

JID - 9002937

EDAT- 2012/05/09 06:00

MHDA- 2012/05/09 06:00

CRDT- 2012/05/09 06:00

PHST- 2012/01/20 [received]

PHST- 2012/03/26 [accepted]

PHST- 2012/05/08 [aheadofprint]

AID - 10.1007/s00405-012-2014-7 [doi]

PST - aheadofprint

SO - Eur Arch Otorhinolaryngol. 2012 May 8.

PMID- 22247285

OWN - NLM STAT- MEDLINE

DA - 20120417

DCOM- 20120606

IS - 1468-2079 (Electronic)

IS - 0007-1161 (Linking)

VI - 96

IP - 5

DP - 2012 May

TI - A new lacrimal bypass tube fixation method to prevent tube displacement in

conjunctivodacryocystorhinostomy (CDCR).

PG - 674-8

AB - AIMS: To evaluate the efficacy of a new lacrimal bypass tube fixation technique

to the conjunctiva and caruncle, preventing postoperative displacement of the

tube in conjunctivodacryocystorhinostomies (CDCRs). METHODS: The authors

conducted 52 CDCR procedures by a new tube fixation technique using a 6-0 prolene

suture encircling the tube neck (encircling group). The suture was not removed

during the follow-up period. Over the same period, the authors carried out 51

CDCRs with tube fixation using a 5-0 vicryl suture with the purse string

procedure (purse string group) and 71 conventional CDCRs with tube fixation to

the skin using a 6-0 nylon suture (control group). Postoperative complications,

including dislodgement and tube length problems, were recorded. The three groups

were statistically compared. RESULTS: Among the 52 cases using the new fixation

technique, tube malpositions, including extrusions, had developed in only four

cases (7.7%) at 12 months after the operation. In the purse string and control

groups, the same complications developed in 11 (21.6%) and 22 cases (31.0%), respectively. A statistically significant difference between these groups was

detected (p=0.008). Other complications, such as conjunctival granulomas and tube

obstruction, developed postoperatively in four cases (8.0%) in the encircling

group, and this did not differ significantly from that in the other groups

(p=0.193). CONCLUSIONS: The authors believe that this encircling fixation

procedure can help in CDCRs for maintaining the location and orientation of the

tube during the early postoperative period.

AD - Department of Ophthalmology, Guro Hospital, Korea University College of Medicine,

97 Gurodong-gil, Guro-gu, Seoul 152-703, Korea.

FAU - Chang, Minwook

AU - Chang M

FAU - Baek, Sehyun

AU - Baek S

FAU - Lee, Tae Soo

AU - Lee TS

LA - eng

PT - Comparative Study

PT - Journal Article

DEP - 20120112

PL - England

TA - Br J Ophthalmol

JT - The British journal of ophthalmology

JID - 0421041

RN - 0 (Nylons)

RN - 34346-01-5 (Polyglactin 910) SB - IM

MH - Conjunctiva/*surgery

MH - Dacryocystorhinostomy/*methods

MH - Female

MH - Foreign-Body Migration/*prevention & control

MH - Glass

MH - Humans

MH - Intubation/*methods

MH - Lacrimal Duct Obstruction/*surgery

MH - Male

MH - Middle Aged

MH - Nasolacrimal Duct/surgery

MH - Nylons

MH - Polyglactin 910

MH - Postoperative Complications/*prevention & control

MH - Retrospective Studies

MH - *Suture Techniques

MH - Sutures

MH - Treatment Outcome

EDAT- 2012/01/17 06:00

MHDA- 2012/06/07 06:00

CRDT- 2012/01/17 06:00

PHST- 2012/01/12 [aheadofprint]

AID - bjophthalmol-2011-300860 [pii]

AID - 10.1136/bjophthalmol-2011-300860 [doi] PST - ppublish

SO - Br J Ophthalmol. 2012 May;96(5):674-8. Epub 2012 Jan 12.

PMID- 21725935

OWN - NLM

STAT- In-Process

DA - 20120511

IS - 1724-6016 (Electronic)

IS - 1120-6721 (Linking)

VI - 22

IP - 3

DP - 2012 May-Jun

TI - Effect of mitomycin C on success rate in dacryocystorhinostomy with silicone tube

intubation and improper flaps.

PG - 326-9

LID - 10.5301/ejo.5000007 [doi]

AB - PURPOSE: To assess the effect of mitomycin C on surgical success rate of

dacryocystorhinostomy and silicone intubation in patients with improper flaps.

METHODS: The study was a randomized clinical trial. The patients with indication

for dacryocystorhinostomy surgery with silicone intubation (inappropriate

lacrimal sac or nasal mucosal flaps during surgery and/or history of

dacryocystitis in the past 3 months) were randomly assigned to application of

mitomycin C (0.02%) on surgical flaps (group A) or a control group without

mitomycin C application (group B). Main outcome measures were subjective

symptomatic improvement and result of irrigation test at last follow-up visit. RESULTS: The study enrolled 88 patients (88 eyes); there were 42 patients in

group A and 46 patients in group B. There was an average follow-up of 10 months

(range 6-15 months) following surgery. Significant improvement (no tearing with

patent lacrimal system in irrigation) was observed in 31 patients (73.8%) in

group A and 32 patients (69.6%) in group B. There was no statistically

significant difference in no improvement (no change in tearing state and

obstruction in irrigation test), relative improvement (decreased tearing and

passage of fluid with force in irrigation test), and significant improvement rate

between the 2 groups of study (p>0.05). CONCLUSIONS: Application of mitomycin C

on surgical flaps during dacryocystorhinostomy surgery with silicone intubation

in patients with improper flaps has no proven beneficial effect on success rate

of surgery.

AD - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences,

Tehran, Iran.

FAU - Eshraghy, Bahram

AU - Eshraghy B

FAU - Raygan, Firoozeh

AU - Raygan F

FAU - Tabatabaie, Syed Ziaeddin

AU - Tabatabaie SZ

FAU - Tari, Ali Sadeghi

AU - Tari AS

FAU - Kasaee, Abolfazl

AU - Kasaee A

FAU - Rajabi, Mohammad Taher AU - Rajabi MT

LA - eng

PT - Journal Article

PL - Italy

TA - Eur J Ophthalmol

JT - European journal of ophthalmology

JID - 9110772

SB - IM

EDAT- 2011/07/05 06:00

MHDA- 2011/07/05 06:00

CRDT- 2011/07/05 06:00

PHST- 2011/05/15 [accepted]

AID - B323DB12-89DC-424A-B139-E90012BFFA9F [pii]

AID - 10.5301/ejo.5000007 [doi]

PST - ppublish

SO - Eur J Ophthalmol. 2012 May-Jun;22(3):326-9. doi: 10.5301/ejo.5000007.

PMID- 22411166

OWN - NLM

STAT- In-Process

DA - 20120515

IS - 1613-2246 (Electronic)

IS - 0021-5155 (Linking)

VI - 56

IP - 3 DP - 2012 May

TI - Dacryoendoscopic observation and incidence of canalicular obstruction/stenosis

associated with S-1, an oral anticancer drug.

PG - 214-8

AB - PURPOSE: To report dacryoendoscopic observations and the incidence of lacrimal

obstruction/stenosis associated with S-1, an oral anticancer drug. DESIGN:

Retrospective, nonrandomized clinical trial. METHODS: A total of 52 patients (41

men, 11 women; age 42-93 years) who were prescribed the anticancer drug S-1 were

studied. Patients who suffered eye complaints following S-1 treatment underwent

ophthalmic examination, probing and lacrimal irrigation. Patients whose tear

meniscus was high or had abnormal lacrimal irrigation were evaluated by

dacryoendoscopy. RESULTS: Overall, 5 of 52 S-1-treated patients (9.6%)

experienced lacrimal passage stenosis/obstruction. One patient had punctal

stenosis, and four patients had canalicular obstruction/stenosis. The onset of

epiphora ranged from 2 to 8 months (4.4 +/- 2.2 months, mean +/- SD) after the

initiation of chemotherapy. CONCLUSIONS: Patients receiving S-1 treatment should

be evaluated for potential lacrimal disorders, particularly canalicular

obstruction/stenosis. Dacryoendoscopic observation is effective for the diagnosis

of this side effect.

AD - Sasaki Eye Clinic, 5-2-6 Mikuni-higashi, Mikuni, Sakai, 913-0016, Japan.

[email protected]

FAU - Sasaki, Tsugihisa

AU - Sasaki T

FAU - Miyashita, Hiroaki

AU - Miyashita H FAU - Miyanaga, Tamon

AU - Miyanaga T

FAU - Yamamoto, Katsushi

AU - Yamamoto K

FAU - Sugiyama, Kazuhisa

AU - Sugiyama K

LA - eng

PT - Journal Article

DEP - 20120313

PL - Japan

TA - Jpn J Ophthalmol

JT - Japanese journal of ophthalmology

JID - 0044652

SB - IM

EDAT- 2012/03/14 06:00

MHDA- 2012/03/14 06:00

CRDT- 2012/03/14 06:00

PHST- 2011/05/16 [received]

PHST- 2012/01/25 [accepted]

PHST- 2012/03/13 [aheadofprint]

AID - 10.1007/s10384-012-0127-6 [doi]

PST - ppublish

SO - Jpn J Ophthalmol. 2012 May;56(3):214-8. Epub 2012 Mar 13.

PMID- 22534704 OWN - NLM

STAT- In-Process

DA - 20120426

IS - 1643-3750 (Electronic)

IS - 1234-1010 (Linking)

VI - 18

IP - 5

DP - 2012 May

TI - Comparison of postoperative pain and satisfaction after dacryocystorhinostomy in

patients operated on under local and general anesthesia.

PG - CR265-70

AB - BACKGROUND: There has been only 1 study on postoperative pain after external

dacryocystorhinostomy (DCR) that compared pain between 2 groups of patients; 1

group received local anesthesia and the other received general anesthesia. To

further characterize the relationship between these 2 types of anesthesia and

postoperative pain, we designed a study in which a single patient received these

2 different anesthesia modalities for a short interval on 2 different sides.

MATERIAL/METHODS: There were 50 participants in this study. External DCR was

performed on the same participant on both sides using local anesthesia on 1 side

and general anesthesia on the other. Postoperative pain was measured using the

visual analogue scale (VAS), and localization and timing of pain were reported by

the participants. Postoperative nausea and vomiting (PONV) were documented if

present. RESULTS: Pain levels were significantly higher with general anesthesia 3

hours post-surgery, and 6 hours post-surgery the pain remains higher following

general anesthesia but is borderline insignificant (p=0.051). However, 12 hours post-surgery, there is no significant difference in the pain level (p=0.240).

There was no significant difference in the localization of pain with local and

general anesthesia. Postoperative nausea is significantly more frequent after

general anesthesia, and vomiting only occurs with general anesthesia. Local

anesthesia was preferred by 94% of the participants (47 out of 50). CONCLUSIONS:

The vast majority of patients in our study who have undergone both GA and LA DCR

would choose LA again, providing a compelling case for use of the LA technique.

AD - Faculty of Medicine, University of Belgrade, Serbia. [email protected]

FAU - Knezevic, Miroslav M

AU - Knezevic MM

FAU - Vlajkovic, Gordana P

AU - Vlajkovic GP

FAU - Stojkovic, Milenko Z

AU - Stojkovic MZ

FAU - Rasic, Dejan M

AU - Rasic DM

FAU - Stankovic, Branislav R

AU - Stankovic BR

FAU - Bozic, Marija M

AU - Bozic MM

LA - eng

PT - Journal Article

PT - Research Support, Non-U.S. Gov't

PL - Poland

TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and

clinical research

JID - 9609063

SB - IM

EDAT- 2012/04/27 06:00

MHDA- 2012/04/27 06:00

CRDT- 2012/04/27 06:00

AID - 882730 [pii]

PST - ppublish

SO - Med Sci Monit. 2012 May;18(5):CR265-70.

PMID- 22283720

OWN - NLM

STAT- In-Process

DA - 20120323

IS - 1460-2202 (Electronic)

IS - 0271-3683 (Linking)

VI - 37

IP - 4

DP - 2012 Apr

TI - Assessment of patient satisfaction following external versus transcanalicular

dacryocystorhinostomy with a diode laser and evaluation if change in quality of

life after simultaneous bilateral surgery in patients with bilateral nasolacrimal

duct obstruction.

PG - 286-92 AB - AIM: To compare patient satisfaction and experience after external

dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode

laser and to evaluate the change in quality of life following simultaneous

bilateral DCR. METHODS: Prospective evaluation of 38 eyes of 19 patients with

bilateral nasolacrimal duct obstruction (NLDO) who underwent TC-DCR for the right

eye (Group 1) and EX-DCR for the left eye (Group 2) simultaneously. The

subjective outcomes (tearing, irritation, pain, discharge, swelling, and change

in visual acuity) of the patients in the two groups at 1 week, 1 month, and 3

months were compared using a questionnaire. The patients answered the questions

in the Glascow Benefit Inventory (GBI) to evaluate the change in quality of life

after simultaneous bilateral DCR at 1 month and 3 months. The symptom scores were

compared between Group 1 and Group 2 using a Mann-Whitney test. The Wilcoxon test

was used for the comparison of intragroup differences. RESULTS: The overall

symptom scores significantly improved in both groups. The overall symptom score

and six ocular symptom scores did not show a significant difference between the

two groups at 1 week, 1 month, and 3 months. Quality of life of the patients

significantly improved after simultaneous bilateral surgery according to GBI

scoring at 1 month and 3 months. CONCLUSION: The subjective outcomes

significantly improved in similar ways after successful TC-DCR and EX-DCR during

the early postoperative period. Our study shows that simultaneous bilateral DCR

confers a significant quality of life improvement.

AD - Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine,

Istanbul, Turkey. [email protected]

FAU - Yeniad, Baris

AU - Yeniad B FAU - Uludag, Gunay

AU - Uludag G

FAU - Kozer-Bilgin, Lale

AU - Kozer-Bilgin L

LA - eng

PT - Journal Article

DEP - 20120127

PL - England

TA - Curr Eye Res

JT - Current eye research

JID - 8104312

SB - IM

EDAT- 2012/01/31 06:00

MHDA- 2012/01/31 06:00

CRDT- 2012/01/31 06:00

PHST- 2012/01/27 [aheadofprint]

AID - 10.3109/02713683.2012.658488 [doi]

PST - ppublish

SO - Curr Eye Res. 2012 Apr;37(4):286-92. Epub 2012 Jan 27.

PMID- 22496009

OWN - NLM

STAT- In-Process

DA - 20120412

IS - 1439-3999 (Electronic) IS - 0023-2165 (Linking)

VI - 229

IP - 4

DP - 2012 Apr

TI - Mucosal excision instead of fashioning nasolacrimal mucosae flaps during external

dacryocystorhinostomy: a pilot study.

PG - 387-90

AB - BACKGROUND: To report results of a simplified external dacryocytorhinostomy

procedure in which nasal and lacrimal sac mucosal flaps are simply removed

instead of being sutured together. PATIENTS AND METHODS: Design: Retrospective

non-comparative case-series study. Participants: Fourteen consecutive outpatients

patients undergoing external dacryocytorhinostomy. Intervention: Modified and

simplified transcutaneous external dacryocytorhinostomy where basically the

lacrimal sac and the nasal mucosae are widely excised in front of DCR's osteotomy

instead of being used to fashion nasolacrimal flaps. Outcome: Assessment of

dacryocytorhinostomy anatomical patency by syringing and patient's

self-perception of epiphora symptoms improvement about twelve weeks and one year

after surgery, as well as patient's report of ocular air-reflux during Valsalva

maneuver a year after surgery. RESULTS: Syringing showed anatomic patency in 93 %

and 92 % of patients twelve weeks (mean +/- SD: 12 weeks +/- 6 weeks) and one

year (15 months +/- 3 months) after surgery, respectively. One year after

surgery, 62 % of patients reported ocular air-reflux. Twelve weeks and one year

after surgery, mean symptom improvement was 82 % +/- 17 % and 79 % +/- 29 %,

respectively. Furthermore, 79 % and 85 % of patients reported a postoperative

improvement of their symptoms greater or equal to 80 % after twelve weeks and one year, respectively. CONCLUSIONS: Removing lacrimal sac and nasal mucosae in front

of the osteotomy did not appear to have a major negative impact on the outcome of

the external dacryocytorhinostomy. The findings of this pilot study need to be

confirmed by a larger prospective trial.

CI - (c) Georg Thieme Verlag KG Stuttgart . New York.

AD - Leonhard's Praxis-Clinic, Basel, Switzerland. [email protected]

FAU - Haefliger, I O

AU - Haefliger IO

FAU - Tschopp, M

AU - Tschopp M

FAU - Pimentel, A-R

AU - Pimentel AR

LA - eng

PT - Journal Article

DEP - 20120411

PL - Germany

TA - Klin Monbl Augenheilkd

JT - Klinische Monatsblatter fur Augenheilkunde

JID - 0014133

SB - IM

EDAT- 2012/04/13 06:00

MHDA- 2012/04/13 06:00

CRDT- 2012/04/13 06:00

PHST- 2012/04/11 [epublish]

AID - 10.1055/s-0031-1299433 [doi] PST - ppublish

SO - Klin Monbl Augenheilkd. 2012 Apr;229(4):387-90. Epub 2012 Apr 11.

PMID- 22489849

OWN - NLM

STAT- MEDLINE

DA - 20120411

DCOM- 20120615

IS - 1744-5108 (Electronic)

IS - 0167-6830 (Linking)

VI - 31

IP - 2

DP - 2012 Apr

TI - A comparison of external and endonasal dacryocystorhinostomy in regard to patient

satisfaction and cost.

PG - 67-76

AB - BACKGROUND: Definitive treatment of nasolacrimal duct obstruction is with

external or endonasal dacryocystorhinostomy (DCR). Recent trials suggest surgical

equivalency between techniques. We sought to compare alternative outcomes of DCR

techniques in terms of quality of life and cost. METHODS: This study was a

multicentre prospective nonrandomized case series comparing adult patients

treated with external or endonasal DCR. Groups were allocated according to DCR

technique. Participation did not affect treatment choice. The Glasgow Benefit

Inventory (GBI) was utilized to compare postoperative quality of life, and an

activity-based costing (ABC) method used to estimate costs of the two techniques. Surgical data were also collected. A minimum of 3 months follow-up was observed.

RESULTS: Seventy-seven patients were included--37 external and 40 endonasal. Both

techniques resulted in positive health status change, with mean GBI scores of

+16.1 for external DCR and +24.1 for endonasal (p = 0.18). Using an ABC method,

the operative costs of external DCR were less than endonasal at $715.79 AUD and

$932.52 AUD respectively. CONCLUSIONS: This trial suggests that external and

endonasal DCR produce comparable outcomes in terms of postoperative quality of

life, with external DCR resulting in lower operative costs.

AD - Department of Ophthalmology, Alfred Hospital, Prahran, Australia.

[email protected]

FAU - Hii, Belinda W

AU - Hii BW

FAU - McNab, Alan A

AU - McNab AA

FAU - Friebel, Justin D

AU - Friebel JD

LA - eng

PT - Comparative Study

PT - Journal Article

PT - Multicenter Study

PL - England

TA - Orbit

JT - Orbit (Amsterdam, Netherlands)

JID - 8301221

SB - IM MH - Adult

MH - Aged

MH - Aged, 80 and over

MH - Dacryocystorhinostomy/*economics/*methods

MH - Female

MH - *Health Care Costs

MH - Humans

MH - Lacrimal Duct Obstruction/*economics/surgery

MH - Male

MH - Middle Aged

MH - Nasolacrimal Duct/*surgery

MH - *Patient Satisfaction

MH - Prospective Studies

MH - Quality of Life

MH - Questionnaires

MH - Sickness Impact Profile

MH - Treatment Outcome

EDAT- 2012/04/12 06:00

MHDA- 2012/06/16 06:00

CRDT- 2012/04/12 06:00

AID - 10.3109/01676830.2011.648803 [doi]

PST - ppublish

SO - Orbit. 2012 Apr;31(2):67-76.

PMID- 21392851 OWN - NLM

STAT- MEDLINE

DA - 20111129

DCOM- 20120403

IS - 1532-818X (Electronic)

IS - 0196-0709 (Linking)

VI - 33

IP - 1

DP - 2012 Jan-Feb

TI - Significance of adjunctive mitomycin C in endoscopic dacryocystorhinostomy.

PG - 47-50

AB - PURPOSE: The purpose of this study is to observe the effect of intraoperative

topical application of mitomycin C (MMC) on the results of endoscopic

dacryocystorhinostomy. DESIGN: This is a prospective, randomized, controlled,

single-blind study. SETTINGS: Hospitalized treatment was done in a tertiary

medical college hospital and research center that deals with a predominantly

rural population. PATIENTS: Patients with primary acquired postsaccal obstruction

causing chronic dacryocystitis were considered. METHODS: A total of 38 patients

were randomized into either a mitomycin group or a control group. Both of these

groups were subjected to an identical surgical procedure, except that 0.2 mg/dL

of MMC was used in the mitomycin group, whereas normal saline was used in the

control group. The follow-up period was at least 6 months. An asymptomatic

patient with a visible stoma at nasendoscopy and free flow of saline into the

nose with lacrimal syringing after 6 months after surgery was used as criteria

for defining a successful result. RESULTS: The success rate was 82.3% when MMC was used and 85.7% among the controls (P > .05). Granulations, adhesions, and

obliterative sclerosis occurred in a similar number of patients of both groups.

However, granulations and adhesions did not have a bearing on the success rate in

either group. CONCLUSION: Mitomycin C did not appear to influence the occurrence

of granulations, synechiae, or obliterative sclerosis, nor did it alter the

success rate significantly.

CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.

AD - Department of Otorhinolaryngology, R.L. Jalappa Hospital and Research Centre, Sri

Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education, Tamaka,

Kolar, India. [email protected]

FAU - Prasannaraj, Thomas

AU - Prasannaraj T

FAU - Kumar, B Y Praveen

AU - Kumar BY

FAU - Narasimhan, Indira

AU - Narasimhan I

FAU - Shivaprakash, K V

AU - Shivaprakash KV

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

DEP - 20110309

PL - United States

TA - Am J Otolaryngol

JT - American journal of otolaryngology JID - 8000029

RN - 0 (Alkylating Agents)

RN - 50-07-7 (Mitomycin)

SB - IM

MH - Administration, Topical

MH - Adolescent

MH - Adult

MH - Alkylating Agents/*administration & dosage

MH - Combined Modality Therapy

MH - Dacryocystitis/*drug therapy/*surgery

MH - Dacryocystorhinostomy/*methods

MH - Endoscopy/*methods

MH - Female

MH - Humans

MH - Intraoperative Period

MH - Male

MH - Middle Aged

MH - Mitomycin/*administration & dosage

MH - Prospective Studies

MH - Single-Blind Method

MH - Treatment Outcome

EDAT- 2011/03/12 06:00

MHDA- 2012/04/04 06:00

CRDT- 2011/03/12 06:00

PHST- 2010/08/24 [received] PHST- 2010/12/16 [revised]

PHST- 2011/01/24 [accepted]

PHST- 2011/03/09 [aheadofprint]

AID - S0196-0709(11)00023-8 [pii]

AID - 10.1016/j.amjoto.2011.01.001 [doi]

PST - ppublish

SO - Am J Otolaryngol. 2012 Jan-Feb;33(1):47-50. Epub 2011 Mar 9.

PMID- 22082600

OWN - NLM

STAT- MEDLINE

DA - 20120120

DCOM- 20120325

IS - 1537-2677 (Electronic)

IS - 0740-9303 (Linking)

VI - 28

IP - 1

DP - 2012 Jan

TI - External dacryocystorhinostomy outcomes in sarcoidosis patients.

PG - 47-9

AB - PURPOSE: To determine surgical outcomes after external dacryocystorhinostomy

(DCR) surgery in patients with sarcoidosis. METHODS: We retrospectively reviewed

the charts of all patients with sarcoidosis who underwent external DCR surgery

between January 2001 and January 2010. Clinical data reviewed included patient

demographics, immunosuppressive therapies, biopsy results, use of intraoperative triamcinolone, and postoperative outcomes and complications. Success was defined

as resolution of epiphora. RESULTS: External DCR was performed on 13 sides of 9

patients with sarcoidosis. Four patients were systemically immunosuppressed with

methotrexate or plaquenil, and 4 patients used inhaled corticosteroids only.

Intraoperative biopsy in 10 cases (9 patients) revealed non-necrotizing

granulomatous inflammation (8 cases) and chronic inflammation (2 cases). Silicone

stents were removed at a mean of 2.9 months. Initial DCR surgery was successful

in 10 of 13 (87%) surgeries with an average follow up of 31 months (range, 14 to

48 months). None of the 5 surgeries (4 patients) with intralesional triamcinolone

injections failed, compared with 3 of 8 (38%) surgeries without intralesional

triamcinolone. Of the 3 failures, 2 early failures (3 months) were successfully

treated with balloon catheter dilation. In the one patient with a late failure

(47 months), subsequent balloon catheter dilation failed. All 3 patients who

experienced failures used inhaled corticosteroids only. In contrast, 4 of the 6

patients with successful surgery were systemically immunosuppressed.

Complications such as punctal erosion, wound necrosis, or cerebrospinal fluid

leak did not occur. CONCLUSIONS: External DCR surgery successfully treats

nasolacrimal duct obstruction associated with sarcoidosis. Intralesional

triamcinolone may improve the success rate without added complications. Long-term

success may be less in patients not receiving systemic immunosuppressive therapy.

AD - Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

FAU - Lee, Brian J

AU - Lee BJ

FAU - Nelson, Christine C

AU - Nelson CC FAU - Lewis, Craig D

AU - Lewis CD

FAU - Perry, Julian D

AU - Perry JD

LA - eng

PT - Journal Article

PL - United States

TA - Ophthal Plast Reconstr Surg

JT - Ophthalmic plastic and reconstructive surgery

JID - 8508431

RN - 0 (Anti-Inflammatory Agents)

RN - 0 (Immunosuppressive Agents)

RN - 124-94-7 (Triamcinolone)

SB - IM

MH - Adult

MH - Anti-Inflammatory Agents/therapeutic use

MH - Dacryocystorhinostomy/*methods

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Immunosuppressive Agents/therapeutic use

MH - Lacrimal Duct Obstruction/drug therapy/etiology/*surgery

MH - Male

MH - Middle Aged

MH - Nasolacrimal Duct/*surgery MH - Perioperative Care

MH - Postoperative Complications

MH - Retrospective Studies

MH - Sarcoidosis/*complications/drug therapy

MH - Triamcinolone/therapeutic use

EDAT- 2011/11/16 06:00

MHDA- 2012/03/27 06:00

CRDT- 2011/11/16 06:00

AID - 10.1097/IOP.0b013e3182364ad2 [doi]

PST - ppublish

SO - Ophthal Plast Reconstr Surg. 2012 Jan;28(1):47-9.

PMID- 22153640

OWN - NLM

STAT- MEDLINE

DA - 20111213

DCOM- 20120330

IS - 0008-4182 (Print)

IS - 0008-4182 (Linking)

VI - 46

IP - 6

DP - 2011 Dec

TI - A meta-analysis of primary dacryocystorhinostomy with and without silicone

intubation.

PG - 521-7 AB - OBJECTIVE: To examine possible differences in success rates of primary

dacryocystorhinostomy (DCR) with and without silicone intubation, and to find out

whether the use of silicone tubes is beneficial. DESIGN: A literature search was

conducted in the PubMed, EMBASE, and Cochrane Controlled Trials Register to

identify potentially relevant controlled trials. METHODS: Language was restricted

to English. The surgical techniques were categorized into external DCR (EX-DCR),

endonasal laser-assisted DCR (LA-DCR), and nonlaser endoscopic endonasal DCR

techniques (EN-DCR). The main outcome measure was success rates after DCR-with

and DCR-without silicone intubation. The statistical analysis was carried out

using a RevMan 5.0 software. RESULTS: Of 188 retrieved trials from the electronic

database, 9 trials (5 randomized controlled trials and 4 cohort studies)

involving 514 cases met our inclusion criteria. There was no statistically

significant heterogeneity between the studies. The pooled risk ratio was 0.99,

with a 95% confidence interval (0.91-1.08). There was no significant difference

in the success rates between the DCR with and without silicone intubation (p =

0.81). Sensitivity analysis and subgroups analyses suggested that the result was

comparatively reliable. CONCLUSIONS: Based on this meta-analysis that included 5

randomized controlled trials and 4 cohort studies, no benefit was found for

silicone tube intubation in primary DCR. Further well-organized, prospective,

randomized studies involving larger patient numbers are required.

CI - Copyright (c) 2011 Canadian Ophthalmological Society. Published by Elsevier Inc.

All rights reserved.

AD - The Affiliated Eye Hospital of Wenzhou Medical College, Zhejiang, China.

FAU - Feng, Yi-Fan

AU - Feng YF FAU - Cai, Jian-Qiu

AU - Cai JQ

FAU - Zhang, Jia-Yu

AU - Zhang JY

FAU - Han, Xiao-Hui

AU - Han XH

LA - eng

PT - Journal Article

PT - Meta-Analysis

PL - England

TA - Can J Ophthalmol

JT - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

JID - 0045312

RN - 0 (Silicones)

SB - IM

MH - *Dacryocystorhinostomy

MH - Databases, Factual

MH - Humans

MH - *Intubation

MH - Lacrimal Duct Obstruction/*therapy

MH - Nasolacrimal Duct/*surgery

MH - Randomized Controlled Trials as Topic

MH - Silicones

MH - *Stents

MH - Treatment Outcome EDAT- 2011/12/14 06:00

MHDA- 2012/03/31 06:00

CRDT- 2011/12/14 06:00

PHST- 2011/01/29 [received]

PHST- 2011/07/08 [revised]

PHST- 2011/09/07 [accepted]

AID - S0008-4182(11)00218-3 [pii]

AID - 10.1016/j.jcjo.2011.09.008 [doi]

PST - ppublish

SO - Can J Ophthalmol. 2011 Dec;46(6):521-7.

PMID- 22185749

OWN - NLM

STAT- MEDLINE

DA - 20111221

DCOM- 20120509

IS - 1945-8932 (Electronic)

IS - 1945-8932 (Linking)

VI - 25

IP - 6

DP - 2011 Nov-Dec

TI - Mitomycin C in revision endoscopic dacryocystorhinostomy: a prospective

randomized study.

PG - 425-8

AB - BACKGROUND: Endoscopic dacryocystorhinostomy (EN-DCR) is an effective and safe procedure when treating saccal and postsaccal nasolacrimal duct obstruction.

However, sometimes scarring of the rhinostomy site caused by fibrosis may occur,

particularly in revision operations. The application of intraoperative mitomycin

C (MMC), an antiproliferative agent, has been introduced as one possible

technique to improve the outcome. We conducted a prospective, randomized study to

evaluate if the use of MMC improves the success in endonasal revision DCR

procedure. METHODS: Thirty revision EN-DCR procedures were performed during

2004-2010. The patients were randomized into two study groups, according to

whether the intraoperative MMC was used or not. The technique of EN-DCR procedure

in both groups was the same, but in the MMC group, at the end of the procedure a

piece of tampon soaked in MMC (0.4 mg/mL) was placed into the rhinostoma for 5

minutes. No silicone stents were inserted. The surgical outcome at the 6-month

follow-up visit was considered successful if the lacrimal sac irrigation

succeeded and if the patients' symptoms were relieved. RESULTS: The success rate

after revision EN-DCR with MMC was 93% and without MMC was 60%. The overall

success rate was 77%. The difference between the two groups was not statistically

significant (p = 0.08). The relief of the symptoms between groups in both the

Nasolacrimal Duct Obstruction Symptom Score and ocular symptoms was statistically

significant (p = 0.007 and p = 0.02, respectively). CONCLUSION: The results of

our study indicate that the application of intraoperative mitomycin C may improve

the outcome in revision EN-DCR.

AD - Department of Otorhinolaryngology, Institute of Clinical Medicine, Kuopio

University Hospital, and University of Eastern Finland, Finland.

FAU - Penttila, Elina

AU - Penttila E FAU - Smirnov, Grigori

AU - Smirnov G

FAU - Seppa, Juha

AU - Seppa J

FAU - Kaarniranta, Kai

AU - Kaarniranta K

FAU - Tuomilehto, Henri

AU - Tuomilehto H

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

PL - United States

TA - Am J Rhinol Allergy

JT - American journal of rhinology & allergy

JID - 101490775

RN - 0 (Antibiotics, Antineoplastic)

RN - 0 (Growth Inhibitors)

RN - 50-07-7 (Mitomycin)

SB - IM

MH - Aged

MH - Aged, 80 and over

MH - Antibiotics, Antineoplastic/*administration & dosage/adverse effects

MH - Cicatrix/*etiology/prevention & control

MH - *Dacryocystorhinostomy

MH - Endoscopy MH - Female

MH - Follow-Up Studies

MH - Growth Inhibitors/*administration & dosage/adverse effects

MH - Humans

MH - Intraoperative Care

MH - Lacrimal Duct Obstruction/complications/*drug therapy/surgery

MH - Male

MH - Middle Aged

MH - Mitomycin/*administration & dosage/adverse effects

MH - Postoperative Complications/etiology/prevention & control

MH - Prospective Studies

MH - Reoperation

MH - Treatment Outcome

EDAT- 2011/12/22 06:00

MHDA- 2012/05/10 06:00

CRDT- 2011/12/22 06:00

AID - 10.2500/ajra.2011.25.3676 [doi]

PST - ppublish

SO - Am J Rhinol Allergy. 2011 Nov-Dec;25(6):425-8.

PMID- 21681436

OWN - NLM

STAT- MEDLINE

DA - 20111028

DCOM- 20120201 IS - 1435-702X (Electronic)

IS - 0721-832X (Linking)

VI - 249

IP - 11

DP - 2011 Nov

TI - Monocanalicular versus bicanalicular intubation in the treatment of congenital

nasolacrimal duct obstruction.

PG - 1729-33

AB - BACKGROUND: To compare the success rate of monocanalicular intubation (MCI)

compared with bicanalicular silicone intubation (BCI) in congenital nasolacrimal

duct obstruction (CNLDO) in infants and toddlers. METHODS: In a prospective,

nonrandomized, comparative study, MCI (n = 35 eyes) through the inferior

canaliculus or BCI (n = 35 eyes) were performed under general anaesthesia in

children aged 10 to 36 months with CNLDO. The tubes were removed 3-4 months after

tube placement, and the children were followed up for 6 months after the removal

of tubes. Therapeutic success was defined as the fluorescein dye disappearance

test grade 0-1, corresponding with a complete resolution of previous symptoms.

Partial success was defined as improvement with some residual symptoms. RESULTS:

Complete and partial improvement was achieved in 31/35 (88.57%) in the BCI group

and 34/35 (97.14%) in the MCI group. The difference between the two groups was

not significant (p = 0.584). Complications occurred in both groups. Dislodgement

of the tube and premature removal was observed in four BCI cases, and loss of the

tube was observed twice in the MCI group. Canalicular slitting was observed in

five eyes in the BCI group. Granuloma pyogenicum observed in 2 cases with MCI

revealed a few weeks after the tube removal. Corneal erosion in the inferior medial quadrant was observed in one MCI eye and revealed in a few days after the

local treatment without tube removal. CONCLUSIONS: Both MCI and the BCI are

effective methods for treating CNLDO. MCI has the advantage of a lower incidence

of canalicular slit and easy placement.

AD - Department of Otolaryngology, University Hospital Ostrava, Ostrava, Czech

Republic. [email protected]

FAU - Kominek, Pavel

AU - Kominek P

FAU - Cervenka, Stanislav

AU - Cervenka S

FAU - Pniak, Tomas

AU - Pniak T

FAU - Zelenik, Karol

AU - Zelenik K

FAU - Tomaskova, Hana

AU - Tomaskova H

FAU - Matousek, Petr

AU - Matousek P

LA - eng

PT - Comparative Study

PT - Journal Article

DEP - 20110617

PL - Germany

TA - Graefes Arch Clin Exp Ophthalmol

JT - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

JID - 8205248

RN - 0 (Silicone Elastomers)

RN - 2321-07-5 (Fluorescein)

SB - IM

MH - Anesthesia, General

MH - Child, Preschool

MH - Device Removal

MH - Female

MH - Fluorescein/metabolism

MH - Humans

MH - Infant

MH - Intubation/*methods

MH - Lacrimal Duct Obstruction/*congenital/physiopathology/*therapy

MH - Male

MH - Nasolacrimal Duct/*abnormalities/physiopathology

MH - Postoperative Complications

MH - Prospective Studies

MH - *Silicone Elastomers

MH - Treatment Outcome

PMC - PMC3203220

OID - NLM: PMC3203220

EDAT- 2011/06/18 06:00

MHDA- 2012/02/02 06:00

CRDT- 2011/06/18 06:00 PHST- 2010/11/08 [received]

PHST- 2011/04/15 [accepted]

PHST- 2011/02/08 [revised]

PHST- 2011/06/17 [aheadofprint]

AID - 10.1007/s00417-011-1700-2 [doi]

PST - ppublish

SO - Graefes Arch Clin Exp Ophthalmol. 2011 Nov;249(11):1729-33. Epub 2011 Jun 17.

PMID- 21632147

OWN - NLM

STAT- MEDLINE

DA - 20111107

DCOM- 20120305

IS - 1773-0597 (Electronic)

IS - 0181-5512 (Linking)

VI - 34

IP - 9

DP - 2011 Nov

TI - Pushed monocanalicular intubation. Pitfalls, deleterious side effects, and

complications.

PG - 597-607

AB - PURPOSE: To present our experience with pushed monocanalicular nasolacrimal

intubation in the management of 90 consecutive cases of nasolacrimal outflow

obstruction. MATERIALS AND METHOD: This paper reports a non-randomized study of

90 consecutive cases treated with a pushed Monoka intubation system (Masterka). A metal guide is placed inside a silicone tube rather than being attached at the distal end of the tube, as done with traditional pulled . Three probe lengths are available: 30, 35, and 40 mm. SURGICAL PROCEDURE: The silicone stent was pushed into a punctum, canaliculus, and nasolacrimal duct by means of the guide. After passing through the valve of Hasner and reaching the nasal floor, the guide was then delicately withdrawn while remaining oriented along the axis of the lacrimal sac and duct. Throughout this phase, the anchoring plug was held in contact with the punctum. Three study groups were set up chronologically: group 1: endo-DCR procedures done with Masterka insertions under endoscopic observation. Group 2: Masterka insertions done with endoscopic guidance. Group 3: blind Masterka insertions without endoscopic guidance. The patients in groups 2 and 3 were selected on the information obtained by lacrimal probing. Only cases with mucosal nasolacrimal stenoses were included. All patients had surgery under general anesthesia with mechanically assisted ventilation (groups 1 and 2) or spontaneous ventilation (group 3). The anchoring plug was inserted into the punctum and vertical canaliculus, either by pulling on the probe (group 1) or using an inserting instrument. RESULTS: A total of 90 pushed Monoka intubations were done. Endoscopic examination (groups 1 and 2) demonstrated visually that the pushed intubation method was effective. In none of the 28 cases did the silicone bunch up when the guide was withdrawn. DEGREE OF DIFFICULTY: This was dependent upon proper selection for pushed Monoka intubation; the length of the probe and confirmation that there no false passage was created. The pushed intubation technique was only slightly more difficult than a simple lacrimal probing. The average operating time, excluding the anesthetic procedures, was respectively 5 min (group 2) and 4 min (group 3). COMPLICATIONS DURING SURGERY: There were no anesthetic or general problems observed in the three groups. Epistaxis was also

not noted. POSTOPERATIVE COMPLICATIONS: Fifteen percent (13/90). The 13

complications noted were: two cases of canaliculitis, one intracanalicular

migration, eight probes that disappeared, one keratitis, and one case of

involuntary removal by the patient. DELETERIOUS SIDE EFFECTS: Tearing with the

probe was in place was noted in 21.1% of the cases (19/90). This tearing

disappeared as soon as the probe was removed in 50% of these cases (10/19).

FUNCTIONAL RESULTS: Overall, the success rate (absence of epiphora, absence of

mucous discharge) was 90% (81/90) with an average follow-up period of 19 weeks

(Range, 1 day to 60 weeks). Two cases were lost to follow-up at day 1 and day 7.

Group 1: 90.9% (20/22 cases; average age: 65 years, with an average follow-up

period of 24 weeks). Group 2: 100% (6/6 cases; average age: 3.1 years, with an

average follow-up period of 14 weeks). Group 3: 88.3% (53/60 cases excluding the

two cases that were lost to follow-up; mean age: 2.3 years, with an average

follow-up period of 16 weeks). CONCLUSIONS: From a technical perspective, pushed

nasolacrimal intubation is much simpler than the traditional pulled types of

nasolacrimal intubation. The anesthetic procedure required is the same as that

for a late probing procedure, but the functional results are better. The Masterka

is an alternative to simple late probing in the treatment of mucosal nasolacrimal

stenoses in patients of over 12 months of age.

CI - Copyright A(c) 2011 Elsevier Masson SAS. All rights reserved.

AD - Department of Ophthalmology, Hotel-Dieu de Paris, University of Paris VI -

Medical School, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France.

[email protected]

FAU - Fayet, B AU - Fayet B

FAU - Racy, E

AU - Racy E

FAU - Ruban, J-M

AU - Ruban JM

FAU - Katowitz, J

AU - Katowitz J

LA - eng

PT - Clinical Trial

PT - Journal Article

DEP - 20110601

PL - France

TA - J Fr Ophtalmol

JT - Journal francais d'ophtalmologie

JID - 7804128

SB - IM

MH - Adult

MH - Aged

MH - Child

MH - Child, Preschool

MH - Endoscopy/adverse effects/methods

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Infant MH - Intubation/*adverse effects/*methods

MH - Lacrimal Duct Obstruction/epidemiology/etiology/*therapy

MH - Male

MH - Mechanical Processes

MH - Middle Aged

MH - Models, Biological

MH - *Nasolacrimal Duct/pathology

MH - Postoperative Complications/epidemiology/etiology

MH - Stents/adverse effects

EDAT- 2011/06/03 06:00

MHDA- 2012/03/06 06:00

CRDT- 2011/06/03 06:00

PHST- 2010/11/15 [received]

PHST- 2011/02/16 [revised]

PHST- 2011/02/18 [accepted]

PHST- 2011/06/01 [aheadofprint]

AID - S0181-5512(11)00159-8 [pii]

AID - 10.1016/j.jfo.2011.02.008 [doi]

PST - ppublish

SO - J Fr Ophtalmol. 2011 Nov;34(9):597-607. Epub 2011 Jun 1.

PMID- 21353409

OWN - NLM

STAT- MEDLINE

DA - 20110418 DCOM- 20110830

IS - 1879-1476 (Electronic)

IS - 0385-8146 (Linking)

VI - 38

IP - 5

DP - 2011 Oct

TI - Primary diffuse large B-cell lymphoma of the lacrimal sac simulating chronic

dacryocystitis.

PG - 643-5

AB - Primary diffuse large B-cell lymphoma of the lacrimal sac is rare. Herein we

report a 55-year-old female presented with epiphora in the right eye. Distention

of the lacrimal sac secondary to nasolacrimal duct obstruction was observed. She

was scheduled for external dacryocystorinostomy for the next month. When she came

for surgery, a growing mass was recognised over the lacrimal sac region. On

computer tomography scan, a subdermal mass causing nasal bone destruction was

detected. Excisional biopsy of the mass was performed. Histopathologic and

immunohistochemical evaluations revealed primary diffuse large B-cell non-Hodgkin

lymphoma of the lacrimal sac. She was treated with cyclophospamide, vincristine,

adriablastine and prednisone for eight courses combined with rituximab for 6

months. During a follow-up period of 25 months, patient is stable with no

systemic disease. Although rare, lacrimal sac tumors can mimic dacryocystitis and

must be considered in differential diagnosis. In suspicious cases incisional

biopsy is recommended.

CI - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.

AD - Ege University Faculty of Medicine, Department of Ophthalmology, Izmir, Turkey. FAU - Palamar, Melis

AU - Palamar M

FAU - Midilli, Rasit

AU - Midilli R

FAU - Ozsan, Nazan

AU - Ozsan N

FAU - Egrilmez, Sait

AU - Egrilmez S

FAU - Sahin, Fahri

AU - Sahin F

FAU - Yagci, Ayse

AU - Yagci A

LA - eng

PT - Case Reports

PT - Journal Article

DEP - 20110224

PL - Netherlands

TA - Auris Nasus Larynx

JT - Auris, nasus, larynx

JID - 7708170

RN - 0 (Antibodies, Monoclonal, Murine-Derived)

RN - 0 (Antineoplastic Agents)

RN - 0 (rituximab)

SB - IM

MH - Antibodies, Monoclonal, Murine-Derived/administration & dosage MH - Antineoplastic Agents/administration & dosage

MH - Antineoplastic Combined Chemotherapy Protocols/administration & dosage

MH - Chronic Disease

MH - Dacryocystitis/*diagnosis

MH - Diagnosis, Differential

MH - Drug Administration Schedule

MH - Eye Neoplasms/*diagnosis/drug therapy

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Lacrimal Apparatus Diseases/*diagnosis/drug therapy

MH - Lymphoma, Large B-Cell, Diffuse/*diagnosis/drug therapy

MH - Middle Aged

EDAT- 2011/03/01 06:00

MHDA- 2011/08/31 06:00

CRDT- 2011/03/01 06:00

PHST- 2010/09/21 [received]

PHST- 2010/12/08 [revised]

PHST- 2011/01/05 [accepted]

PHST- 2011/02/24 [aheadofprint]

AID - S0385-8146(11)00036-8 [pii]

AID - 10.1016/j.anl.2011.01.012 [doi]

PST - ppublish

SO - Auris Nasus Larynx. 2011 Oct;38(5):643-5. Epub 2011 Feb 24.

PMID- 21957956

OWN - NLM

STAT- MEDLINE

DA - 20110930

DCOM- 20120203

IS - 1744-5108 (Electronic)

IS - 0167-6830 (Linking)

VI - 30

IP - 5

DP - 2011 Oct

TI - Acute dacryocystitis associated with epstein-barr virus infection.

PG - 245-8

AB - Acute dacryocystitis is a rare complication of infectious mononucleosis with only

three previous reports in the English literature. We present two further children

with acute dacryocystitis and clinical and laboratory features of Epstein-Barr

Virus related infectious mononucleosis. Both were treated with systemic

antibiotics and one child additionally required surgical drainage of a lacrimal

sac abscess. Both children made a complete recovery without any lacrimal

symptoms. Acute dacryocystitis is uncommon in children without a history of

congenital nasolacrimal duct obstruction, and an underlying systemic condition

such as infectious mononucleosis should be suspected. In such patients,

dacryocystitis can be expected to resolve without symptoms of nasolacrimal duct

obstruction and dacryocystorhinostomy is seldom required.

AD - Victoria Eye Unit, Hereford County Hospital, Hereford, United Kingdom.

FAU - Ghauri, Abdul-Jabbar AU - Ghauri AJ

FAU - Keane, Pearse A

AU - Keane PA

FAU - Scotcher, Stephen M

AU - Scotcher SM

FAU - Clarke, Jayne L

AU - Clarke JL

FAU - Madge, Simon N

AU - Madge SN

LA - eng

PT - Case Reports

PT - Journal Article

PL - England

TA - Orbit

JT - Orbit (Amsterdam, Netherlands)

JID - 8301221

RN - 443-48-1 (Metronidazole)

RN - 73384-59-5 (Ceftriaxone)

SB - IM

MH - Acute Disease

MH - Ceftriaxone/therapeutic use

MH - Child

MH - Child, Preschool

MH - Combined Modality Therapy

MH - Dacryocystitis/drug therapy/*etiology/physiopathology MH - Drainage/methods

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Infectious Mononucleosis/*complications/diagnosis/drug therapy

MH - Infusions, Intravenous

MH - Lacrimal Duct Obstruction/etiology/physiopathology/*therapy

MH - Male

MH - Metronidazole/therapeutic use

MH - Risk Assessment

MH - Treatment Outcome

EDAT- 2011/10/01 06:00

MHDA- 2012/02/04 06:00

CRDT- 2011/10/01 06:00

AID - 10.3109/01676830.2011.584933 [doi]

PST - ppublish

SO - Orbit. 2011 Oct;30(5):245-8.

PMID- 21613626

OWN - NLM

STAT- MEDLINE

DA - 20110928

DCOM- 20111122

IS - 1097-6817 (Electronic)

IS - 0194-5998 (Linking) VI - 145

IP - 4

DP - 2011 Oct

TI - Endocanalicular, high-pressure balloon catheter, endoscopic

dacryocystorhinostomy: a randomized controlled trial.

PG - 683-8

AB - OBJECTIVES: To conduct a prospective randomized controlled study to investigate

the safety and efficacy of endocanalicular, high-pressure, 5-mm balloon catheter,

endoscopic dacryocystorhinostomy (DCR) in adult patients with acquired complete

nasolacrimal obstruction. STUDY DESIGN: Prospective randomized controlled study.

SETTING: General hospital. SUBJECTS AND METHODS: Sixty-six adult patients with a

total of 70 procedures were recruited to undergo endoscopic DCR. They were

prospectively, equally randomized into 2 groups: endocanalicular, high-pressure,

5-mm balloon catheter, endoscopic DCR (group I) and conventional endoscopic DCR

(group II). Regular follow-up sessions were conducted to document the patient's

subjective improvement, judge ostium patency on irrigation, and record any

complications. RESULTS: Both groups demonstrated a success rate of 91.4%. There

was a shorter mean operative time (25.7 minutes) in group I (P < .001). The

number of adverse events was significantly higher in group II (P < .05). Group I

showed statistically significantly more comfort during surgery under local

anesthesia with minimal sedation (P < .05). CONCLUSION: Endocanalicular balloon

catheter endoscopic DCR shares the advantages and success rate of conventional

endoscopic DCR. In addition, the former is simpler, requires less manipulation,

consumes a shorter operative time, has a better safety profile, and can be

conducted under local anesthesia with minimal sedation. AD - Tanta University Hospitals, Tanta, Egypt. [email protected]

FAU - Ragab, Sameh M

AU - Ragab SM

FAU - el-Koddousy, Mona S

AU - el-Koddousy MS

FAU - Badr, Mohammed

AU - Badr M

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

DEP - 20110525

PL - England

TA - Otolaryngol Head Neck Surg

JT - Otolaryngology--head and neck surgery : official journal of American Academy of

Otolaryngology-Head and Neck Surgery

JID - 8508176

SB - IM

MH - Adult

MH - Balloon Dilation/*methods

MH - Dacryocystorhinostomy/*methods

MH - Endoscopes

MH - Endoscopy/instrumentation/*methods

MH - Equipment Design

MH - Female

MH - Humans MH - Lacrimal Duct Obstruction/*therapy

MH - Male

MH - Middle Aged

MH - *Nasolacrimal Duct

MH - Prospective Studies

MH - Young Adult

EDAT- 2011/05/27 06:00

MHDA- 2011/12/13 00:00

CRDT- 2011/05/27 06:00

PHST- 2011/05/25 [aheadofprint]

AID - 0194599811410534 [pii]

AID - 10.1177/0194599811410534 [doi]

PST - ppublish

SO - Otolaryngol Head Neck Surg. 2011 Oct;145(4):683-8. Epub 2011 May 25.

PMID- 21730837

OWN - NLM

STAT- MEDLINE

DA - 20110811

DCOM- 20120118

IS - 1531-7021 (Electronic)

IS - 1040-8738 (Linking)

VI - 22

IP - 5

DP - 2011 Sep TI - Laser-assisted dacryocystorhinostomy: a viable treatment option?

PG - 413-8

AB - PURPOSE OF REVIEW: Improvements in endoscopic instrumentation and evolving laser

technologies have renewed interest in laser-assisted endonasal applications, and

an increasing number of lacrimal surgeons have focused on laser-assisted

approaches to dacryocystorhinostomy (DCR). The purpose of this review was to

assess the clinical efficacy of laser-assisted DCR techniques with a particular

focus on the endocanalicular approach and to describe various laser systems and

their associated tissue effects. RECENT FINDINGS: Recent studies of

endocanalicular laser DCR suggest favorable success rates that are comparable

with external and endonasal endoscopic DCR, although there is a shortage of

robust, prospective, randomized studies. SUMMARY: Recent evidence suggests that

endocanalicular laser DCR is a well tolerated, viable treatment option for

nasolacrimal duct obstruction in selected patients with favorable results and

shorter operative times. More recent studies seem to suggest improvements in

success rates compared with older studies, although additional, well designed,

comparative studies are needed.

AD - Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine,

Houston, Texas 77030, USA.

FAU - Lee, Seongmu

AU - Lee S

FAU - Yen, Michael T

AU - Yen MT

LA - eng

PT - Journal Article PT - Research Support, Non-U.S. Gov't

PT - Review

PL - United States

TA - Curr Opin Ophthalmol

JT - Current opinion in ophthalmology

JID - 9011108

SB - IM

MH - Dacryocystorhinostomy/*methods

MH - *Endoscopy

MH - Female

MH - Humans

MH - Lacrimal Duct Obstruction/physiopathology/*surgery

MH - Laser Therapy/*methods

MH - Male

MH - Patient Selection

MH - Randomized Controlled Trials as Topic

MH - Treatment Outcome

EDAT- 2011/07/07 06:00

MHDA- 2012/01/19 06:00

CRDT- 2011/07/07 06:00

AID - 10.1097/ICU.0b013e32834994c8 [doi]

PST - ppublish

SO - Curr Opin Ophthalmol. 2011 Sep;22(5):413-8.

PMID- 21779017 OWN - NLM

STAT- MEDLINE

DA - 20110908

DCOM- 20111109

IS - 1476-5454 (Electronic)

IS - 0950-222X (Linking)

VI - 25

IP - 9

DP - 2011 Sep

TI - A clinical trial of endoscopic vs external dacryocystorhinostomy for partial

nasolacrimal duct obstruction.

PG - 1219-24

LID - 10.1038/eye.2011.77 [doi]

AB - OBJECTIVE: A literature review revealed there is no outcome data for endoscopic

endonasal dacryocystorhinostomy (EES-DCR) in the subgroup of patients with

acquired partial nasolacrimal duct obstruction (NDO). This study aimed to compare

the results of EES-DCR vs external DCR (ext-DCR) in the treatment of partial NDO.

DESIGN: This study is designed as a prospective nonrandomised comparative

clinical trial. PARTICIPANTS: In total, 46 adult patients with acquired partial

NDO participated in this study. METHODS: Partial (sometimes called 'functional')

NDO (epiphora in the presence of patent syringing) was confirmed by nuclear

lacrimal scintigraphy or delayed drainage on dacryocystography. Patients with

'functional' epiphora from other causes were excluded. Post-operative outcome was

assessed at 6 months. Overall, 21 (46%) patients had EES-DCR and 25 patients had

(54%) ext-DCR. MAIN OUTCOME MEASURES: Subjective success was based on patient symptoms, objective success on patency with syringing and a functioning

rhinostomy evaluated using the functional endoscopic dye test (FEDT). RESULTS: In

total 18 out of 21 (86%) of EES-DCR patients had marked reduction (n=11) or

complete resolution (n=7) and 25 out of 25 (100%) of ext-DCR had marked reduction

(n=9) or complete resolution (n=16) of epiphora. In total 17 out of 18 (94%) of

the EES-DCR patients with subjective success had a positive FEDT. All 25 out of

25 (100%) ext-DCR patients with subjective success had a positive FEDT. The three

failed EES-DCR patients were all blocked on syringing. Statistically, EES-DCR

does not achieve the same success rate as ext-DCR in this study (P=0.09,

two-tailed Fisher's exact test, 0.045 one-tailed). CONCLUSIONS: Both endoscopic

and external DCRs provide satisfactory outcomes in acquired partial NDO. The

success rate is nevertheless higher in ext-DCR compared with EES-DCR.

AD - Department of Ophthalmology, Charing Cross and Hammersmith Hospitals, London, UK.

[email protected]

FAU - Zaidi, F H

AU - Zaidi FH

FAU - Symanski, S

AU - Symanski S

FAU - Olver, J M

AU - Olver JM

LA - eng

PT - Clinical Trial

PT - Comparative Study

PT - Journal Article

DEP - 20110722 PL - England

TA - Eye (Lond)

JT - Eye (London, England)

JID - 8703986

SB - IM

MH - Adult

MH - Aged

MH - Aged, 80 and over

MH - Dacryocystorhinostomy/*methods

MH - *Endoscopy

MH - Female

MH - Humans

MH - Lacrimal Duct Obstruction/*surgery

MH - Male

MH - Middle Aged

MH - Nasolacrimal Duct/*surgery

MH - Outcome Assessment (Health Care)

MH - Prospective Studies

PMC - PMC3178258

OID - NLM: PMC3178258 [Available on 09/01/12]

EDAT- 2011/07/23 06:00

MHDA- 2011/11/10 06:00

CRDT- 2011/07/23 06:00

PMCR- 2012/09/01 00:00

PHST- 2011/07/22 [aheadofprint] AID - eye201177 [pii]

AID - 10.1038/eye.2011.77 [doi]

PST - ppublish

SO - Eye (Lond). 2011 Sep;25(9):1219-24. doi: 10.1038/eye.2011.77. Epub 2011 Jul 22.

PMID- 21333092

OWN - NLM

STAT- MEDLINE

DA - 20110808

DCOM- 20111202

IS - 1945-8932 (Electronic)

IS - 1945-8932 (Linking)

VI - 25

IP - 4

DP - 2011 Jul-Aug

TI - What is the role of partial middle turbinectomy in endocanalicular laser-assisted

endonasal dacryocystorhinostomy?

PG - e160-5

AB - BACKGROUND: This study was designed to compare outcomes of endocanalicular

laser-assisted endonasal dacryocystorhinostomy (DCR) with and without partial

anterior middle turbinectomy. METHODS: A prospective randomized comparative study

was conducted on 91 subjects with primary acquired nasolacrimal duct obstruction,

undergoing endocanalicular (ECL) procedures. Group 1 was composed of 44 (7

bilateral) patients undergoing ECL diode laser-assisted endonasal DCR without

partial anterior middle turbinectomy and group 2 was composed of 47 (7 bilateral) patients undergoing partial anterior middle turbinectomy and ECL diode

laser-assisted endonasal DCR. Follow-up period was 11.0 (6.0-14.5 months) months

for group 1 and 9.2 (5.0-14.2 months) months for group 2. Functional success was

defined as absence of epiphora and anatomic success was defined as ability to

irrigate the lacrimal system. Anatomic and functional success at the 1st week,

3rd month, and final postoperative examinations of two groups were compared using

chi-square tests. RESULTS: Final anatomic successes were 39/51 (76%) cases for

group 1 and 51/54 (94%) cases for group 2. Final functional successes were 36/51

(%71) patients in group 1 and 48/54 (88%) patients in group 2. Group 2 had higher

success at the final examination and the difference was statistically

significant. CONCLUSION: We recommend partial anterior middle turbinectomy in all

laser ECL laser-assisted endonasal DCR, but further studies with larger sample

sizes are needed to strengthen our hypothesis.

AD - Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty,

Eskisehir, Turkey. [email protected]

FAU - Basmak, Hikmet

AU - Basmak H

FAU - Cakli, Hamdi

AU - Cakli H

FAU - Sahin, Afsun

AU - Sahin A

FAU - Gursoy, Huseyin

AU - Gursoy H

FAU - Ozer, Ahmet

AU - Ozer A FAU - Colak, Ertugrul

AU - Colak E

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

PT - Research Support, Non-U.S. Gov't

DEP - 20110211

PL - United States

TA - Am J Rhinol Allergy

JT - American journal of rhinology & allergy

JID - 101490775

SB - IM

MH - Adult

MH - Aged

MH - *Dacryocystorhinostomy

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Lacrimal Apparatus/*metabolism/pathology/surgery

MH - Lacrimal Apparatus Diseases/diagnosis/pathology/physiopathology/*surgery

MH - Lasers/utilization

MH - Male

MH - Middle Aged

MH - Nasolacrimal Duct/pathology/*surgery

MH - Prospective Studies MH - Recovery of Function

MH - Turbinates/pathology/*surgery

EDAT- 2011/02/22 06:00

MHDA- 2011/12/13 00:00

CRDT- 2011/02/22 06:00

PHST- 2011/02/11 [aheadofprint]

AID - 3598 [pii]

AID - 10.2500/ajra.2011.25.3598 [doi]

PST - ppublish

SO - Am J Rhinol Allergy. 2011 Jul-Aug;25(4):e160-5. Epub 2011 Feb 11.

PMID- 21394118

OWN - NLM

STAT- MEDLINE

DA - 20110609

DCOM- 20110908

LR - 20120619

IS - 1476-5454 (Electronic)

IS - 0950-222X (Linking)

VI - 25

IP - 6

DP - 2011 Jun

TI - Effects of Merogel coverage on wound healing and ostial patency in endonasal

endoscopic dacryocystorhinostomy for primary chronic dacryocystitis.

PG - 746-53 LID - 10.1038/eye.2011.44 [doi]

AB - PURPOSE: To investigate the effects of Merogel coverage on ostial patency in

endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic

dacryocystitis (PCD). METHODS: In all, 260 patients with unilateral PCD were

randomized into two groups: the Merogel group and the control group. All patients

underwent EES-DCR. The Merogel group received Merogel covering the wound 1-2 mm

around the ostium and the control group received no treatment. Patients were

followed up for 9 months. The mucosal epithelialization of the wound, the

proliferation of fibrosis tissue, and the success rate of ostial patency were

compared. RESULTS: Our study included 112 patients in the Merogel group and 115

patients in the control group. At the 2-week review, intact mucosal epithelium

lined the ostia in 96 Merogel patients compared with 80 control patients (ITT

analysis: chi(2)=4.502, P=0.034). At the 9-month review, scars were present in 18

patients in the Merogel group compared with 39 patients in the control group (ITT

analysis: chi(2)=9.909, P=0.002, ITT analysis). No differences were observed in

the granulation formation between the two groups. The success rate of ostial

patency reached 94.6% (106/112) in the Merogel group compared with 80% (92/115)

in the control group (ITT analysis: chi(2)=4.151, P=0.042). CONCLUSION: Merogel

coverage may enhance the success rate of EES-DCR for PCD by promoting mucosal

epithelial healing and preventing excessive scarring.

AD - Department of Orbital and Oculoplasty Surgery, Eye Hospital of Wenzhou Medical

College, Wenzhou, Zhejiang, PR China. [email protected]

FAU - Wu, W

AU - Wu W

FAU - Cannon, P S AU - Cannon PS

FAU - Yan, W

AU - Yan W

FAU - Tu, Y

AU - Tu Y

FAU - Selva, D

AU - Selva D

FAU - Qu, J

AU - Qu J

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

DEP - 20110311

PL - England

TA - Eye (Lond)

JT - Eye (London, England)

JID - 8703986

RN - 443-48-1 (Metronidazole)

RN - 9004-61-9 (Hyaluronic Acid)

SB - IM

MH - Adult

MH - Chronic Disease

MH - Dacryocystitis/*drug therapy/surgery

MH - Dacryocystorhinostomy/*methods

MH - *Endoscopy MH - Epithelium/pathology

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Hyaluronic Acid/*therapeutic use

MH - Male

MH - Metronidazole/pharmacokinetics/*pharmacology

MH - Middle Aged

MH - Nasal Mucosa/pathology

MH - Wound Healing/*drug effects

PMC - PMC3178118

OID - NLM: PMC3178118

EDAT- 2011/03/12 06:00

MHDA- 2011/09/09 06:00

CRDT- 2011/03/12 06:00

PHST- 2011/03/11 [aheadofprint]

AID - eye201144 [pii]

AID - 10.1038/eye.2011.44 [doi]

PST - ppublish

SO - Eye (Lond). 2011 Jun;25(6):746-53. doi: 10.1038/eye.2011.44. Epub 2011 Mar 11.

PMID- 21356145

OWN - NLM

STAT- MEDLINE

DA - 20111206 DCOM- 20120327

IS - 1748-5460 (Electronic)

IS - 0022-2151 (Linking)

VI - 125

IP - 6

DP - 2011 Jun

TI - Efficacy of endonasal dacryocystorhinostomy, using 'cold steel' instruments

without stenting, in treatment of distal nasolacrimal duct obstruction.

PG - 590-4

AB - OBJECTIVE: To assess the efficacy of an endonasal dacryocystorhinostomy technique

using conventional instruments, without the use of any adjunctive techniques.

STUDY DESIGN: Prospective, non-randomised, cohort study. METHODS: Patients

diagnosed with nasolacrimal duct obstruction between January 2006 and December

2008 were included in the study. Seventy-eight endonasal dacryocystorhinostomies

(primary or revision) were performed with conventional 'cold steel' instruments.

The technique involved complete exposure and marsupialisation of the lacrimal

sac. No adjunctive procedures were used. Success was defined as complete

resolution of epiphora and a patent lacrimal system, evaluated by lacrimal

irrigation and endoscopy, one year post-operatively. RESULTS: Seventy-four of the

78 cases were symptom-free after a minimum follow up of 12 months, giving an

overall success rate of 94.9 per cent. The success rates for primary and revision

cases were 95.5 and 90.9 per cent, respectively. CONCLUSION: Meticulous surgical

technique can ensure high success rates with the use of conventional cold steel

instruments, without the use of adjunctive procedures, making endonasal

dacryocystorhinostomy a cost-effective, reliable procedure. AD - Department of Otorhinolaryngology, Sri Siddhartha Medical College Hospital and

Research Center, Siddhartha University, Tumkur, Karnataka, India.

FAU - Ananth, L

AU - Ananth L

FAU - Hosamani, P

AU - Hosamani P

FAU - Chary, G

AU - Chary G

LA - eng

PT - Journal Article

DEP - 20110228

PL - England

TA - J Laryngol Otol

JT - The Journal of laryngology and otology

JID - 8706896

RN - 12597-69-2 (Steel)

SB - AIM

SB - IM

MH - Adolescent

MH - Adult

MH - Aged

MH - Child

MH - Child, Preschool

MH - Cost-Benefit Analysis

MH - Dacryocystorhinostomy/economics/instrumentation/*methods/statistics & numerical data

MH - Female

MH - Humans

MH - Lacrimal Apparatus Diseases/surgery

MH - Lacrimal Duct Obstruction/*surgery

MH - Male

MH - Middle Aged

MH - Nasal Mucosa/surgery

MH - Nasolacrimal Duct/*surgery

MH - *Natural Orifice Endoscopic Surgery

MH - Prospective Studies

MH - Reoperation

MH - Steel

MH - Surgical Flaps

MH - Treatment Outcome

MH - Young Adult

EDAT- 2011/03/02 06:00

MHDA- 2012/03/28 06:00

CRDT- 2011/03/02 06:00

PHST- 2011/02/28 [aheadofprint]

AID - S002221511100017X [pii]

AID - 10.1017/S002221511100017X [doi]

PST - ppublish

SO - J Laryngol Otol. 2011 Jun;125(6):590-4. Epub 2011 Feb 28.

PMID- 21255867

OWN - NLM

STAT- MEDLINE

DA - 20110328

DCOM- 20110719

LR - 20111117

IS - 1773-0597 (Electronic)

IS - 0181-5512 (Linking)

VI - 34

IP - 3

DP - 2011 Mar

TI - [Fusobacterium nucleatum isolated from a patient presenting lachrymal

canaliculitis].

PG - 188.e1-4

AB - A 68-year-old woman presented with a painless inflammation of the right superior

eyelid that had started several weeks before. The clinical diagnosis concluded in

canaliculitis and the solid concretions were surgically extracted from the

superior canalicula. The anaerobic bacteria Fusobacterium nucleatum sp. nucleatum

was isolated. Signs dramatically regressed two weeks after surgery followed by

one course of oral amoxicillin and clavulanic acid associated with topical

tobramycin. The clinical signs had disappeared two months later.

CI - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

AD - Laboratoire de biologie, centre hospitalier national d'ophtalmologie des

Quinze-Vingt, 28, rue de Charenton, 75012 Paris, France.

FAU - Borsali, E AU - Borsali E

FAU - Goldschmidt, P

AU - Goldschmidt P

FAU - Mann, F

AU - Mann F

FAU - Sterkers, M

AU - Sterkers M

FAU - Le Bouter, A

AU - Le Bouter A

FAU - Ailem, N

AU - Ailem N

FAU - Legrand, P

AU - Legrand P

FAU - Gaujoux, T

AU - Gaujoux T

FAU - Batellier, L

AU - Batellier L

FAU - Sullam-Rea, M-L

AU - Sullam-Rea ML

FAU - Bouaziz, T

AU - Bouaziz T

FAU - Sahel, J A

AU - Sahel JA

FAU - Chaumeil, C

AU - Chaumeil C LA - fre

PT - Case Reports

PT - English Abstract

PT - Journal Article

TT - Fusobacterium nucleatum isole chez un patient presentant une canaliculite.

DEP - 20110120

PL - France

TA - J Fr Ophtalmol

JT - Journal francais d'ophtalmologie

JID - 7804128

RN - 0 (Anti-Bacterial Agents)

RN - 32986-56-4 (Tobramycin)

RN - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)

RN - Canaliculitis

SB - IM

MH - Aged

MH - Amoxicillin-Potassium Clavulanate Combination/administration & dosage/therapeutic

use

MH - Anti-Bacterial Agents/administration & dosage/therapeutic use

MH - Combined Modality Therapy

MH - Corneal Ulcer/microbiology

MH - Dacryocystitis

MH - Dacryocystorhinostomy

MH - Drug Therapy, Combination

MH - Emergencies MH - Female

MH - Fusobacterium Infections/complications/drug therapy/*microbiology/surgery

MH - Fusobacterium nucleatum/*isolation & purification

MH - Humans

MH - Lacrimal Apparatus Diseases/complications/drug therapy/*microbiology/surgery

MH - Lacrimal Duct Obstruction/etiology/surgery

MH - Tobramycin/administration & dosage/therapeutic use

EDAT- 2011/01/25 06:00

MHDA- 2011/07/20 06:00

CRDT- 2011/01/25 06:00

PHST- 2010/07/06 [received]

PHST- 2010/10/12 [accepted]

PHST- 2011/01/20 [aheadofprint]

AID - S0181-5512(10)00327-X [pii]

AID - 10.1016/j.jfo.2010.10.012 [doi]

PST - ppublish

SO - J Fr Ophtalmol. 2011 Mar;34(3):188.e1-4. Epub 2011 Jan 20.

PMID- 21224749

OWN - NLM

STAT- MEDLINE

DA - 20110307

DCOM- 20110525

IS - 1537-2677 (Electronic)

IS - 0740-9303 (Linking) VI - 27

IP - 2

DP - 2011 Mar-Apr

TI - Results of lacrimal gland botulinum toxin injection for epiphora in lacrimal

obstruction and gustatory tearing.

PG - 119-21

AB - PURPOSE: To describe the author's experience with the use of botulinum toxin

(Botox, Allergan Inc., Irvine, CA, U.S.A.) injection in the palpebral lobe of the

lacrimal gland for symptomatic epiphora due to lacrimal obstruction or gustatory

tearing. METHODS: This is a retrospective review of 46 patients treated by the

author with botulinum toxin injection in the palpebral lobe of the lacrimal gland

for symptomatic epiphora due to lacrimal obstruction or gustatory tearing from

2001 through 2008. All patients were injected with 2.5 units of botulinum toxin,

and the patients' subjective responses were assessed 1 to 2 weeks later. If there

was insufficient response, they were reinjected with an additional 2.5 units of

botulinum toxin and re-evaluated in 1 to 2 weeks. The response to the treatment

and complications were evaluated. RESULTS: Overall, 74% of patients treated felt

that tearing was mostly or completely improved. The only complication was

temporary ptosis in 11% of the patients. CONCLUSION: Botulinum toxin injection in

the palpebral lobe of the lacrimal gland can be used effectively and safely for

symptomatic epiphora due to lacrimal obstruction and gustatory tearing. Although

the beneficial results are temporary, the patient satisfaction in selected

patients is high.

AD - The Emory Clinic, Atlanta, Georgia 30322, USA. [email protected]

FAU - Wojno, Ted H AU - Wojno TH

LA - eng

PT - Journal Article

PT - Research Support, Non-U.S. Gov't

PL - United States

TA - Ophthal Plast Reconstr Surg

JT - Ophthalmic plastic and reconstructive surgery

JID - 8508431

RN - 0 (Neuromuscular Agents)

RN - 0 (onabotulinumtoxinA)

RN - EC 3.4.24.69 (Botulinum Toxins, Type A)

SB - IM

MH - Adult

MH - Aged

MH - Aged, 80 and over

MH - Botulinum Toxins, Type A/*administration & dosage

MH - Female

MH - Humans

MH - Injections, Intraocular

MH - Lacrimal Apparatus/*drug effects/secretion

MH - Lacrimal Apparatus Diseases/*drug therapy/etiology/metabolism

MH - Lacrimal Duct Obstruction/complications/drug therapy/metabolism

MH - Male

MH - Middle Aged

MH - Neuromuscular Agents/*administration & dosage MH - Patient Satisfaction

MH - Retrospective Studies

MH - Tears/secretion

MH - Treatment Outcome

EDAT- 2011/01/13 06:00

MHDA- 2011/05/26 06:00

CRDT- 2011/01/13 06:00

AID - 10.1097/IOP.0b013e318201d1d3 [doi]

PST - ppublish

SO - Ophthal Plast Reconstr Surg. 2011 Mar-Apr;27(2):119-21.

PMID- 21271601

OWN - NLM

STAT- MEDLINE

DA - 20110128

DCOM- 20110308

IS - 1531-4995 (Electronic)

IS - 0023-852X (Linking)

VI - 121

IP - 2

DP - 2011 Feb

TI - Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy.

PG - 433-6

LID - 10.1002/lary.21292 [doi]

AB - OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of intraoperative mitomycin C (MMC) in endonasal endoscopic dacryocystorhinostomy. STUDY DESIGN: Randomized

controlled trial. METHODS: Fifty patients with primary acquired nasolacrimal duct

obstruction were enrolled and randomly allocated into the treatment and control

group. The patients underwent standard endonasal endoscopic dacryocystorhinostomy

with mucosal flaps and mitomycin C or placebo on each group. The ostium size was

measured at 3 months, 6 months, and 12 months to evaluate the effect of mitomycin

C and placebo, and the patency of the lacrimal drainage system was assessed.

RESULTS: There was no statistical significance in the success rate between the

MMC group and the control group at 1-year follow-up (84.6% vs.79.2%,

respectively, P = .59). At the 6-month and 12-month visits, the mean ostium size

in the MMC group was 10.8 mm(2) (SD = 3.17) and 3.0 mm(2) (SD = 1.78),

respectively, which were prominently larger than the control group at 7.1 mm(2)

(SD = 2.62; P < .001, 95% CI, 0.84-5.45) and 1.6 mm(2) (SD = 1.18; P = .004, 95%

CI, 0.49-2.38). CONCLUSIONS: There was no statistically significant difference in

the success rates of both groups, but MMC seems to have a conspicuous effect on

the healing process at the ostium.

CI - Copyright (c) 2011 The American Laryngological, Rhinological, and Otological

Society, Inc.

AD - Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and

King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

[email protected]

FAU - Tirakunwichcha, Suppapong

AU - Tirakunwichcha S

FAU - Aeumjaturapat, Songklot

AU - Aeumjaturapat S FAU - Sinprajakphon, Siripong

AU - Sinprajakphon S

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

DEP - 20110104

PL - United States

TA - Laryngoscope

JT - The Laryngoscope

JID - 8607378

RN - 50-07-7 (Mitomycin)

SB - IM

MH - Adult

MH - Dacryocystorhinostomy/*methods

MH - *Endoscopy

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Intraoperative Period

MH - Lacrimal Duct Obstruction/surgery

MH - Male

MH - Mitomycin/*therapeutic use

MH - Nasolacrimal Duct/*surgery

EDAT- 2011/01/29 06:00

MHDA- 2011/03/09 06:00 CRDT- 2011/01/29 06:00

PHST- 2010/07/23 [accepted]

PHST- 2011/01/04 [aheadofprint]

AID - 10.1002/lary.21292 [doi]

PST - ppublish

SO - Laryngoscope. 2011 Feb;121(2):433-6. doi: 10.1002/lary.21292. Epub 2011 Jan 4.

PMID- 21249688

OWN - NLM

STAT- MEDLINE

DA - 20110120

DCOM- 20110228

LR - 20110309

IS - 1469-493X (Electronic)

IS - 1361-6137 (Linking)

IP - 1

DP - 2011

TI - Endonasal versus external dacryocystorhinostomy for nasolacrimal duct

obstruction.

PG - CD007097

AB - BACKGROUND: Dacryocystorhinostomy (DCR) procedures can be performed using

external or endonasal approaches. The comparative success rates of these

procedures are unknown. OBJECTIVES: To compare the success rates of external and

endonasal approaches to DCR. SEARCH STRATEGY: We searched CENTRAL (which contains

the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 11), MEDLINE (January 1950 to December 2010), EMBASE (January 1980 to

December 2010), Latin American and Caribbean Literature on Health Sciences

(LILACS) (January 1982 to December 2010), the metaRegister of Controlled Trials

(mRCT) (www.controlled-trials.com) (December 2010), ClinicalTrials.gov

(www.clinicaltrials.gov) (December 2010) and Web of Science Conference

Proceedings Citation Index- Science (CPCI-S) (January 1990 to December 2010).

There were no language or date restrictions in the search for trials. The

electronic databases were last searched on 7 December 2010. We requested or

examined relevant conference proceedings for appropriate trials. SELECTION

CRITERIA: We included all randomised controlled trials (RCTs) comparing external

and endonasal dacryocystorhinostomies. DATA COLLECTION AND ANALYSIS: Two review

authors independently performed data extraction and assessment of quality with a

predefined form. We contacted investigators to clarify the methodological quality

of the studies. MAIN RESULTS: We identified one trial that fulfilled the

inclusion criteria. This trial compared 64 DCR procedures (32 external and 32

endonasal procedures). Endonasal DCR was four times more likely to fail compared

to external DCR. This was statistically significant (95% confidence interval (CI)

1.25 to 12.84). AUTHORS' CONCLUSIONS: The only trial included in the review

provides evidence that endonasal DCR has statistically higher risk of failure

compared to external DCR. However, this conclusion is limited by paucity of RCTs,

small number of participants and lack of clarity of the methodological process.

Well conducted RCTs with sufficient power are required to answer the research

question.

AD - St Paul's Eye Unit, Royal Liverpool and Broadgreen University Hospital,

Liverpool, UK, L7 8XP. FAU - Anijeet, Deepa

AU - Anijeet D

FAU - Dolan, Lynne

AU - Dolan L

FAU - Macewen, Caroline J

AU - Macewen CJ

LA - eng

PT - Journal Article

PT - Review

DEP - 20110119

PL - England

TA - Cochrane Database Syst Rev

JT - Cochrane database of systematic reviews (Online)

JID - 100909747

SB - IM

MH - Dacryocystorhinostomy/*methods

MH - Humans

MH - Lacrimal Duct Obstruction/*surgery

MH - Randomized Controlled Trials as Topic

MH - Treatment Failure

EDAT- 2011/01/21 06:00

MHDA- 2011/03/01 06:00

CRDT- 2011/01/21 06:00

AID - 10.1002/14651858.CD007097.pub2 [doi]

PST - epublish SO - Cochrane Database Syst Rev. 2011 Jan 19;(1):CD007097.

PMID- 21207444

OWN - NLM

STAT- Publisher

DA - 20110105

IS - 1531-4995 (Electronic)

IS - 0023-852X (Linking)

DP - 2011 Jan 4

TI - Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy.

AB - OBJECTIVES/HYPOTHESIS:: To evaluate the efficacy of intraoperative mitomycin C

(MMC) in endonasal endoscopic dacryocystorhinostomy. STUDY DESIGN:: Randomized

controlled trial. METHODS:: Fifty patients with primary acquired nasolacrimal

duct obstruction were enrolled and randomly allocated into the treatment and

control group. The patients underwent standard endonasal endoscopic

dacryocystorhinostomy with mucosal flaps and mitomycin C or placebo on each

group. The ostium size was measured at 3 months, 6 months, and 12 months to

evaluate the effect of mitomycin C and placebo, and the patency of the lacrimal

drainage system was assessed. RESULTS:: There was no statistical significance in

the success rate between the MMC group and the control group at 1-year follow-up

(84.6% vs.79.2%, respectively, P = .59). At the 6-month and 12-month visits, the

mean ostium size in the MMC group was 10.8 mm(2) (SD = 3.17) and 3.0 mm(2) (SD =

1.78), respectively, which were prominently larger than the control group at 7.1

mm(2) (SD = 2.62; P < .001, 95% CI, 0.84-5.45) and 1.6 mm(2) (SD = 1.18; P =

.004, 95% CI, 0.49-2.38). CONCLUSIONS:: There was no statistically significant difference in the success rates of both groups, but MMC seems to have a

conspicuous effect on the healing process at the ostium.

AD - Departments of Ophthalmology , Faculty of Medicine, Chulalongkorn University and

King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

AU - Tirakunwichcha S

AU - Aeumjaturapat S

AU - Sinprajakphon S

LA - ENG

PT - JOURNAL ARTICLE

DEP - 20110104

TA - Laryngoscope

JT - The Laryngoscope

JID - 8607378

EDAT- 2011/01/06 06:00

MHDA- 2011/01/06 06:00

CRDT- 2011/01/06 06:00

AID - 10.1002/lary.21292 [doi]

PST - aheadofprint

SO - Laryngoscope. 2011 Jan 4.

PMID- 22553710

OWN - NLM

STAT- In-Data-Review

DA - 20120503

IS - 2227-4898 (Electronic) IS - 2222-3959 (Linking)

VI - 4

IP - 5

DP - 2011

TI - Aerocyst urethral catheter insertion compared to expansion sponges application in

external dacryocystorhinostomy.

PG - 498-501

AB - AIM: To evaluate the clinical effect and complications of two different filling

materials (aerocyst urethral catheter and expansion sponges) applying in external

dacryocystorhinostomy (EXT-DCR) and compare their advantages and disadvantages.

METHODS: A retrospective study was made in the period from April, 1 2000 to

April, 1 2005. Totally 180 patients (240 eyes) underwent the EX-DCR using

different filling materials and divided into three groups randomly: negative

control groups (group 1), expansion sponges group (group 2) and aerocyst urethral

catheter group (group 3). The gender, etiology, clinical findings, surgical

technique, filling materials, the condition of ocular surface and complications

were analyzed. Filling materials were removed during day 7. Postoperative success

was determined by lacrimal patency to irrigation, a positive dye test, hemorrhage

and errhysis conditions after extubation and subjective resolution of epiphora

and liquor puris. RESULTS: During a mean follow-up of 5.14+/-1.69 years, the

success rate were 73.7% (group 1), 86.5% (group 2), 98.7% (group 3) in three

groups. There was significant statistical difference among three groups in the

surgical success rate and the operative complications (including hemorrhage,

errhysis, periorbital ecchymosis after extubation)(P<0.05). CONCLUSION: EXT-DCR

with aerocyst urethral cathete intraoperatively have higher success rate, fewer operative complications and a high patient satisfaction ,and can be used to

simplify and speed up traditional EXT-DCR.

AD - Department of Ophthalmology, the First Affiliated Hospital of Nanchang

University, Nanchang 330006, Jiangxi Province, China.

FAU - Shao, Yi

AU - Shao Y

FAU - Yu, Yao

AU - Yu Y

FAU - Pei, Chong-Gang

AU - Pei CG

FAU - Zhou, Qiong

AU - Zhou Q

FAU - Dong, Wen-Jia

AU - Dong WJ

FAU - Qu, Yangluowa

AU - Qu Y

FAU - Yang, Lu

AU - Yang L

FAU - Gao, Gui-Ping

AU - Gao GP

LA - eng

PT - Journal Article

DEP - 20111018

PL - China

TA - Int J Ophthalmol JT - International journal of ophthalmology

JID - 101553860

PMC - PMC3340728

OID - NLM: PMC3340728

EDAT- 2011/01/01 00:00

MHDA- 2011/01/01 00:00

CRDT- 2012/05/04 06:00

PHST- 2011/07/27 [received]

PHST- 2011/09/23 [accepted]

PHST- 2011/10/18 [epublish]

AID - 10.3980/j.issn.2222-3959.2011.05.08 [doi]

AID - ijo-04-05-498 [pii]

PST - ppublish

SO - Int J Ophthalmol. 2011;4(5):498-501. Epub 2011 Oct 18.

PMID- 21276064

OWN - NLM

STAT- MEDLINE

DA - 20110131

DCOM- 20110602

LR - 20111117

IS - 1525-1470 (Electronic)

IS - 0736-8046 (Linking)

VI - 28

IP - 1 DP - 2011 Jan-Feb

TI - Case report: Congenital dacryocystocele and dacryocystitis.

PG - 70-2

LID - 10.1111/j.1525-1470.2010.01365.x [doi]

AB - Congenital dacryocystocele is a uncommon type of nasolacrimal duct obstruction.

Differential diagnosis for masses in the medial canthal region of a newborn

include encephalocele, hemangioma, nasal glioma, and dermoid cyst. Because of the

risk of becoming infected (acute dacryocystitis) and potentially lethal due to

septicemia, aggressive management, including admission for intravenous

antibiotics and surgical removal, is now advocated by many pediatric

ophthalmologists if the cyst cannot be decompressed. Because of the commonly

associated nasal cyst, infants with nasolacrimal dacryocyctocele may also

experience respiratory distress especially when breast-feeding. The following

case of dacryocystocele, which had progressed to dacryocystitis, was misdiagnosed

as an infantile hemangioma. It is important to diagnose this entity quickly and

refer for appropriate antibiotic and surgical management to avoid more serious

sequelae of sepsis and possible death.

CI - (c) 2011 Wiley Periodicals, Inc.

AD - Department of Pediatrics, Geisinger Medical Center, Danville, PA 17821, USA.

[email protected]

FAU - Fussell, J Nicole F

AU - Fussell JN

FAU - Wilson, Thomas

AU - Wilson T

FAU - Pride, Howard AU - Pride H

LA - eng

PT - Case Reports

PT - Journal Article

DEP - 20110125

PL - United States

TA - Pediatr Dermatol

JT - Pediatric dermatology

JID - 8406799

RN - 0 (Anti-Bacterial Agents)

RN - Hemangioma, capillary infantile

SB - IM

MH - Anti-Bacterial Agents/therapeutic use

MH - Dacryocystitis/*congenital/*diagnosis/drug therapy/surgery

MH - Diagnosis, Differential

MH - Female

MH - Hemangioma, Capillary/congenital/diagnosis

MH - Humans

MH - Infant, Newborn

MH - Lacrimal Apparatus Diseases/*congenital/*diagnosis/drug therapy/urine

MH - Lacrimal Duct Obstruction/congenital/diagnosis/surgery

MH - Neoplastic Syndromes, Hereditary

MH - Treatment Outcome

EDAT- 2011/02/01 06:00

MHDA- 2011/06/03 06:00 CRDT- 2011/02/01 06:00

PHST- 2011/01/25 [aheadofprint]

AID - 10.1111/j.1525-1470.2010.01365.x [doi]

PST - ppublish

SO - Pediatr Dermatol. 2011 Jan-Feb;28(1):70-2. doi: 10.1111/j.1525-1470.2010.01365.x.

Epub 2011 Jan 25.

PMID- 21194883

OWN - NLM

STAT- MEDLINE

DA - 20110118

DCOM- 20110224

IS - 0755-4982 (Print)

IS - 0755-4982 (Linking)

VI - 40

IP - 1 Pt 2

DP - 2011 Jan

TI - Pulmonary manifestations of Sjogren's syndrome.

PG - e49-64

AB - Sjogren's syndrome is a chronic inflammatory disorder characterized by

lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary

glands. However, extraglandular organ systems may frequently be involved,

including the lungs. Although subclinical pulmonary inflammation exists in more

than 50% of patients, clinically significant pulmonary involvement affects

approximately 10% of patients and may be the first manifestation of the disease. The entire respiratory tract may be involved, with a wide spectrum of

manifestations including xerotrachea and bronchial sicca, obstructive small

airway disease, various patterns of interstitial lung disease, lymphoinfiltrative

or lymphoproliferative lung disease, such as lymphoma (usually of MALT type),

pulmonary hypertension, pleural involvement, lung cysts, and pulmonary

amyloidosis.

CI - Copyright A(c) 2010 Elsevier Masson SAS. All rights reserved.

AD - Service de medecine interne, Centre national de reference des maladies

systemiques et auto-immunes rares (sclerodermie), universite Lille2, CHRU de

Lille, place de Verdun, 59037 Lille, France. [email protected]

FAU - Hatron, Pierre-Yves

AU - Hatron PY

FAU - Tillie-Leblond, Isabelle

AU - Tillie-Leblond I

FAU - Launay, David

AU - Launay D

FAU - Hachulla, Eric

AU - Hachulla E

FAU - Fauchais, Anne Laure

AU - Fauchais AL

FAU - Wallaert, Benoit

AU - Wallaert B

LA - eng

PT - Journal Article

PT - Review DEP - 20101230

PL - France

TA - Presse Med

JT - Presse medicale (Paris, France : 1983)

JID - 8302490

SB - IM

MH - Humans

MH - Lung Diseases/diagnosis/drug therapy/*etiology

MH - Lung Diseases, Interstitial/etiology

MH - Pleural Diseases/etiology

MH - Sjogren's Syndrome/*complications

EDAT- 2011/01/05 06:00

MHDA- 2011/02/25 06:00

CRDT- 2011/01/04 06:00

PHST- 2010/09/22 [received]

PHST- 2010/11/12 [revised]

PHST- 2010/11/15 [accepted]

PHST- 2010/12/30 [aheadofprint]

AID - S0755-4982(10)00645-7 [pii]

AID - 10.1016/j.lpm.2010.11.002 [doi]

PST - ppublish

SO - Presse Med. 2011 Jan;40(1 Pt 2):e49-64. Epub 2010 Dec 30.

PMID- 21442083

OWN - NLM STAT- MEDLINE

DA - 20110407

DCOM- 20110726

IS - 0300-0729 (Print)

IS - 0300-0729 (Linking)

VI - 48

IP - 4

DP - 2010 Dec

TI - Symptom score questionnaire for nasolacrimal duct obstruction in adults--a novel

tool to assess the outcome after endoscopic dacryocystorhinostomy.

PG - 446-51

AB - BACKGROUND: The incidence of nasolacrimal pathway obstruction increases with age,

and dacryocystorhinostomy (DCR) is a commonly applied surgical technique to treat

severe cases. However, no disease-specific tools to assess the symptoms and the

subjective outcome after DCR have been established. We have developed a specific

Nasolacrimal Duct Obstruction Symptom Score (NLDO-SS) questionnaire to evaluate

the outcome, and tested it in a prospective clinical trial. STUDY DESIGN:

Prospective clinical follow-up study. METHODS: Sixty-eight consecutive primary

endoscopic dacryocystorhinostomy (EN-DCR) procedures were performed in 64

patients during 2004-2008. Preoperatively and during the three follow-up visits

(at 1 week, 2 and 6 months), the patients filled in the NLDO-SS, and at the

second and third follow-up visits they also filled in the Glasgow Benefit

Inventory (GBI) questionnaire. At one year after the operation, a GBI

questionnaire was sent to the patients. RESULTS: The surgical success rate of

EN-DCR was 93 %. EN-DCR resulted in a significant reduction in all of the eight symptoms scores of the NLDO-SS (p= 0.001). The GBI scores indicated a significant

benefit at 2 months (+37 (SD; 28) and an even higher benefit at 6 months after

surgery (+52 (SD; 29), p= 0.001), but no further improvement was found between 6

and 12 months (+52 vs +52, p= 1.0). The correlation between the total GBI and

NLDO-SS was significant (p=0.001). CONCLUSIONS: EN-DCR significantly improves the

quality of life as measured by the GBI. The NLDO-SS correlated with the GBI and

gave more information about the benefits after EN-DCR than GBI alone. The NLDO-SS

proved to be an effective tool to evaluate lacrimal obstructions and EN-DCR

benefits. Further studies to validate NLDO-SS are needed.

AD - Department of Otorhinolaryngology, Institute of Clinical Medicine, Kuopio

University Hospital, and University of Eastern Finland, Finland.

FAU - Smirnov, Grigori

AU - Smirnov G

FAU - Tuomilehto, Henri

AU - Tuomilehto H

FAU - Kokki, Hannu

AU - Kokki H

FAU - Kemppainen, Tatu

AU - Kemppainen T

FAU - Kiviniemi, Vesa

AU - Kiviniemi V

FAU - Nuutinen, Juhani

AU - Nuutinen J

FAU - Kaarniranta, Kai

AU - Kaarniranta K FAU - Seppa, Juha

AU - Seppa J

LA - eng

PT - Clinical Trial

PT - Journal Article

PL - Netherlands

TA - Rhinology

JT - Rhinology

JID - 0347242

SB - IM

MH - Age Factors

MH - Aged

MH - *Dacryocystorhinostomy

MH - Endoscopy

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - *Lacrimal Duct Obstruction/diagnosis/pathology/physiopathology/surgery

MH - Male

MH - Middle Aged

MH - Monitoring, Physiologic/*standards

MH - Nasolacrimal Duct/pathology/physiopathology/surgery

MH - Patient Satisfaction/*statistics & numerical data

MH - Perioperative Period/*standards

MH - Prospective Studies MH - Quality Assurance, Health Care/methods

MH - *Questionnaires

MH - Severity of Illness Index

MH - Sickness Impact Profile

MH - Treatment Outcome

EDAT- 2011/03/29 06:00

MHDA- 2011/07/27 06:00

CRDT- 2011/03/29 06:00

AID - 10.4193/Rhin [doi]

PST - ppublish

SO - Rhinology. 2010 Dec;48(4):446-51.

PMID- 21119404

OWN - NLM

STAT- MEDLINE

DA - 20101201

DCOM- 20110602

IS - 1536-3732 (Electronic)

IS - 1049-2275 (Linking)

VI - 21

IP - 6

DP - 2010 Nov

TI - Surgical outcomes of primary and revision endoscopic dacryocystorhinostomy.

PG - 1706-8

AB - OBJECTIVE: In the current study, whereas the results of endoscopic primary and revision endoscopic dacryocystorhinostomies (END-DCR) were evaluated, the success

rates in patients who did or did not undergo nasal surgery were also compared.

METHODS: A retrospective medical record review of 70 patients (with a total of 72

affected cases) who were admitted to our clinic with a primary complaint of

epiphora between January 2002 and July 2009 was performed. Patients who required

additional nasal procedures were also included in the analysis. A successful DCR

was defined as relief of symptoms on testing with irrigation at the last

follow-up visit. RESULTS: The success rates were 82.1% (23/28 DCRs) in the

primary END-DCR group and 84.1% (37/44 DCRs) in the revision END-DCR group. There

were no significant differences between the groups regarding overall surgical

success rates (P = 0.829). The need for additional nasal surgery was

significantly higher in the revision cases (52.3%) than the primary cases (28.6%;

P = 0.048). No significant difference regarding success rates existed between the

patients who required an additional septoplasty or ancillary sinus surgery and

the patients who did not have nasal pathology and underwent END-DCR alone (P =

0.456). The mean follow-up period was 11 months in the revision END-DCR group and

8 months in the primary END-DCR group. CONCLUSIONS: Endoscopic DCR should be

considered as the treatment of choice in cases with intranasal pathologies.

Endoscopic DCR is a safe and effective procedure in revision cases, as well as in

primary cases.

AD - Department of Otorhinolaryngology, Vakif Gureba Training and Research Hospital,

Istanbul, Turkey. [email protected]

FAU - Korkut, Arzu Yasemin

AU - Korkut AY

FAU - Teker, Aysenur Meric AU - Teker AM

FAU - Yazici, Mine Zahide

AU - Yazici MZ

FAU - Kahya, Volkan

AU - Kahya V

FAU - Gedikli, Orhan

AU - Gedikli O

FAU - Kayhan, Fatma Tulin

AU - Kayhan FT

LA - eng

PT - Comparative Study

PT - Journal Article

PL - United States

TA - J Craniofac Surg

JT - The Journal of craniofacial surgery

JID - 9010410

SB - D

MH - Adult

MH - Aged

MH - Dacryocystorhinostomy/*methods

MH - Endoscopy/*methods

MH - Ethmoid Sinus/surgery

MH - Female

MH - Follow-Up Studies

MH - Granulation Tissue/surgery MH - Humans

MH - Lacrimal Apparatus Diseases/surgery

MH - Lacrimal Duct Obstruction/surgery

MH - Male

MH - Middle Aged

MH - Nasal Septum/surgery

MH - Reoperation

MH - Retrospective Studies

MH - Tissue Adhesions/surgery

MH - Treatment Outcome

MH - Turbinates/surgery

MH - Young Adult

EDAT- 2010/12/02 06:00

MHDA- 2011/06/03 06:00

CRDT- 2010/12/02 06:00

AID - 10.1097/SCS.0b013e3181f3c6c1 [doi]

AID - 00001665-201011000-00011 [pii]

PST - ppublish

SO - J Craniofac Surg. 2010 Nov;21(6):1706-8.

PMID- 21280534

OWN - NLM

STAT- MEDLINE

DA - 20110201

DCOM- 20110519 IS - 0125-2208 (Print)

IS - 0125-2208 (Linking)

VI - 93 Suppl 6

DP - 2010 Nov

TI - Probing and syringing with 3% solution of NaCl and/or 0.2 mg/ml mitomycin-C in

nasolacrimal duct obstruction patients.

PG - S197-202

AB - OBJECTIVE: To compare the efficacy of lacrimal probing and syringing among 3%

solution of Sodium Chloride and/or 0.2 mg/ ml Mitomycin-C as an adjunctive

medication. DESIGN: A prospective, randomized, 2 by 2 factorial design study.

MATERIAL AND METHOD: Forty-eight of nasolacrimal duct obstruction patients with

epiphora symptom were randomly assigned to receive either Normal Saline Solution

or 3% solution of Sodium Chloride or 0.2 mg/ml Mitomycin-C solution or combined

3% solution of Sodium Chloride with 0.2 mg/ml Mitomycin-C solution, during office

probing and syringing. The intervention was performed repeatedly at week 0, weeks

2 and 4. An assessment of epiphora with Visual Analogue Scale were evaluated at

week 0, weeks 2, 4, 8 and 12. RESULTS: Probing and syringing was successfully

reducing epiphora symptom. Mitomycin-C group showed a significant reduction in

mean difference of Visual Analogue Scale score compared with Normal Saline

Solution group (2.85, 95% CI: 1.164-4.536, p < 0.001) and 3% Sodium Chloride

group (2.175, 95% CI: 0.489-3.861, p < 0.01). No complication or adverse event

was found. CONCLUSION: 0.2 mg/ml Mitomycin-C solution of was the most effective

medication for office probing and syringing in reducing epiphora symptom in

nasolacrimal duct obstruction patients.

AD - Department of Ophthalmology, Phramongkutklao College of Medicine, Bangkok, Thailand. [email protected]

FAU - Choontanom, Raveewan

AU - Choontanom R

LA - eng

PT - Journal Article

PT - Randomized Controlled Trial

PT - Research Support, Non-U.S. Gov't

PL - Thailand

TA - J Med Assoc Thai

JT - Journal of the Medical Association of Thailand = Chotmaihet thangphaet

JID - 7507216

RN - 0 (Antibiotics, Antineoplastic)

RN - 50-07-7 (Mitomycin)

RN - 7647-14-5 (Sodium Chloride)

SB - IM

MH - Adult

MH - Aged

MH - Antibiotics, Antineoplastic/*administration & dosage

MH - Female

MH - Humans

MH - Lacrimal Duct Obstruction/*therapy

MH - Male

MH - Middle Aged

MH - Mitomycin/*administration & dosage

MH - Nasolacrimal Duct/*surgery MH - Pain Measurement

MH - Prospective Studies

MH - Sodium Chloride/therapeutic use

MH - Syringes

MH - Therapeutic Irrigation/*methods

MH - Treatment Outcome

EDAT- 2011/02/02 06:00

MHDA- 2011/05/20 06:00

CRDT- 2011/02/02 06:00

PST - ppublish

SO - J Med Assoc Thai. 2010 Nov;93 Suppl 6:S197-202.

PMID- 21121125

OWN - NLM

STAT- MEDLINE

DA - 20101201

DCOM- 20110110

IS - 0023-2157 (Print)

IS - 0023-2157 (Linking)

VI - 112

IP - 7-9

DP - 2010

TI - [Treatment of nasolacrimal duct obstruction with probing in children younger than

4 years].

PG - 221-2 AB - PURPOSE: To evaluate the efficacy of nasolacrimal duct probing as the treatment

of nasolacrimal duct obstruction in children younger than 4 years. MATERIAL AND

METHODS: A total amount of 320 eyes in 275 children 4 to 48 months old, receiving

nasolacrimal duct probing were enrolled in a retrospective study. The patients

were divided into 4 groups depends on age: I group--4-12 months, II group--12-24

months, III group--24-36 months and IV group--36-48 months. RESULTS: The

percentage of efficient duct probing was: in I group--84%, in II group--79%, in

III group--78% and in IV group--59%. CONCLUSIONS: In children 4 to 36 months old,

probing is a successful treatment of nasolacrimal duct obstruction with no

decline in treatment success with increasing age.

AD - Z Kliniki Okulistyki Dzieciecej z Osodkiem Leczenia Zeza Uniwersytetu Medycznego

w Bialymstoku. [email protected]

FAU - Mrugacz, Malgorzata

AU - Mrugacz M

FAU - Sielicka, Danuta

AU - Sielicka D

FAU - Bakunowicz-Lazarczyk, Alina

AU - Bakunowicz-Lazarczyk A

LA - pol

PT - Comparative Study

PT - English Abstract

PT - Journal Article

TT - Leczenie niedroznosci drog lzowych za pomoca sondowania drog lzowych u dzieci w

wieku ponizej 4 lat.

PL - Poland TA - Klin Oczna

JT - Klinika oczna

JID - 0376614

SB - IM

MH - Child, Preschool

MH - Female

MH - Follow-Up Studies

MH - Humans

MH - Infant

MH - Lacrimal Duct Obstruction/*congenital/*surgery

MH - Male

MH - Nasolacrimal Duct/*abnormalities/*surgery

MH - Ophthalmologic Surgical Procedures/methods

MH - Poland

MH - Therapeutic Irrigation/*methods

MH - Treatment Outcome

EDAT- 2010/12/03 06:00

MHDA- 2011/01/11 06:00

CRDT- 2010/12/03 06:00

PST - ppublish

SO - Klin Oczna. 2010;112(7-9):221-2.