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Record #1 of 15 ID: CN-00801300 AU: Wu W AU: Cannon PS AU: Yan W AU: Tu Y AU: Selva D AU: Qu J TI: Effects of Merogel Coverage O

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Record #1 of 15 ID: CN-00801300 AU: Wu W AU: Cannon PS AU: Yan W AU: Tu Y AU: Selva D AU: Qu J TI: Effects of Merogel Coverage O Record #1 of 15 ID: CN-00801300 AU: Wu W AU: Cannon PS AU: Yan W AU: Tu Y AU: Selva D AU: Qu J TI: Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryocystorhinostomy for primary chronic dacryocystitis. SO: Eye (London, England) YR: 2011 VL: 25 NO: 6 PG: 746-53 PM: PUBMED 21394118 PT: Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/300/CN-00801300/frame.html KY: Chronic Disease; Dacryocystitis [drug therapy] [surgery]; Dacryocystorhinostomy [methods]; Endoscopy; Epithelium [pathology]; Follow-Up Studies; Hyaluronic Acid [therapeutic use]; Metronidazole [pharmacokinetics] [pharmacology]; Nasal Mucosa [pathology]; Wound Healing [drug effects]; Adult; Female; Humans; Male; Middle Aged AB: PURPOSE: To investigate the effects of Merogel coverage on ostial patency in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic dacryocystitis (PCD).METHODS: In all, 260 patients with unilateral PCD were randomized into two groups: the Merogel group and the control group. All patients underwent EES-DCR. The Merogel group received Merogel covering the wound 1-2&thinsp;mm around the ostium and the control group received no treatment. Patients were followed up for 9 months. The mucosal epithelialization of the wound, the proliferation of fibrosis tissue, and the success rate of ostial patency were compared.RESULTS: Our study included 112 patients in the Merogel group and 115 patients in the control group. At the 2-week review, intact mucosal epithelium lined the ostia in 96 Merogel patients compared with 80 control patients (ITT analysis: &chi;(2)=4.502, P=0.034). At the 9- month review, scars were present in 18 patients in the Merogel group compared with 39 patients in the control group (ITT analysis: &chi;(2)=9.909, P=0.002, ITT analysis). No differences were observed in the granulation formation between the two groups. The success rate of ostial patency reached 94.6% (106/112) in the Merogel group compared with 80% (92/115) in the control group (ITT analysis: &chi;(2)=4.151, P=0.042).CONCLUSION: Merogel coverage may enhance the success rate of EES-DCR for PCD by promoting mucosal epithelial healing and preventing excessive scarring. Record #2 of 15 ID: CN-00778619 AU: Tirakunwichcha S AU: Aeumjaturapat S AU: Sinprajakphon S TI: Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy. SO: The Laryngoscope YR: 2011 VL: 121 NO: 2 PG: 433-6 PM: PUBMED 21271601 PT: Journal Article; Randomized Controlled Trial AD: Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/619/CN-00778619/frame.html KY: Dacryocystorhinostomy [methods]; Endoscopy; Follow-Up Studies; Intraoperative Period; Lacrimal Duct Obstruction [surgery]; Mitomycin [therapeutic use]; Nasolacrimal Duct [surgery]; Adult; Female; Humans; Male AB: OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of intraoperative mitomycin C (MMC) in endonasal endoscopic dacryocystorhinostomy.STUDY DESIGN: Randomized controlled trial.METHODS: Fifty patients with primary acquired nasolacrimal duct obstruction were enrolled and randomly allocated into the treatment and control group. The patients underwent standard endonasal endoscopic dacryocystorhinostomy with mucosal flaps and mitomycin C or placebo on each group. The ostium size was measured at 3 months, 6 months, and 12 months to evaluate the effect of mitomycin C and placebo, and the patency of the lacrimal drainage system was assessed.RESULTS: There was no statistical significance in the success rate between the MMC group and the control group at 1-year follow-up (84.6% vs.79.2%, respectively, P = .59). At the 6-month and 12-month visits, the mean ostium size in the MMC group was 10.8 mm(2) (SD = 3.17) and 3.0 mm(2) (SD = 1.78), respectively, which were prominently larger than the control group at 7.1 mm(2) (SD = 2.62; P < .001, 95% CI, 0.84-5.45) and 1.6 mm(2) (SD = 1.18; P = .004, 95% CI, 0.49-2.38).CONCLUSIONS: There was no statistically significant difference in the success rates of both groups, but MMC seems to have a conspicuous effect on the healing process at the ostium. Record #3 of 15 ID: CN-00811598 AU: Ragab SM AU: el-Koddousy MS AU: Badr M TI: Endocanalicular, high-pressure balloon catheter, endoscopic dacryocystorhinostomy: a randomized controlled trial. SO: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology- Head and Neck Surgery YR: 2011 VL: 145 NO: 4 PG: 683-8 PM: PUBMED 21613626 PT: Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/598/CN-00811598/frame.html KY: Balloon Dilation [methods]; Dacryocystorhinostomy [methods]; Endoscopes; Endoscopy [instrumentation] [methods]; Equipment Design; Lacrimal Duct Obstruction [therapy]; Nasolacrimal Duct; Prospective Studies; Adult; Female; Humans; Male; Middle Aged; Young Adult AB: OBJECTIVES: To conduct a prospective randomized controlled study to investigate the safety and efficacy of endocanalicular, high-pressure, 5-mm balloon catheter, endoscopic dacryocystorhinostomy (DCR) in adult patients with acquired complete nasolacrimal obstruction.STUDY DESIGN: Prospective randomized controlled study.SETTING: General hospital.SUBJECTS AND METHODS: Sixty-six adult patients with a total of 70 procedures were recruited to undergo endoscopic DCR. They were prospectively, equally randomized into 2 groups: endocanalicular, high-pressure, 5-mm balloon catheter, endoscopic DCR (group I) and conventional endoscopic DCR (group II). Regular follow-up sessions were conducted to document the patient's subjective improvement, judge ostium patency on irrigation, and record any complications.RESULTS: Both groups demonstrated a success rate of 91.4%. There was a shorter mean operative time (25.7 minutes) in group I (P < .001). The number of adverse events was significantly higher in group II (P < .05). Group I showed statistically significantly more comfort during surgery under local anesthesia with minimal sedation (P < .05).CONCLUSION: Endocanalicular balloon catheter endoscopic DCR shares the advantages and success rate of conventional endoscopic DCR. In addition, the former is simpler, requires less manipulation, consumes a shorter operative time, has a better safety profile, and can be conducted under local anesthesia with minimal sedation. Record #4 of 15 ID: CN-00812568 AU: Basmak H AU: Cakli H AU: Sahin A AU: Gursoy H AU: Ozer A AU: Colak E TI: What is the role of partial middle turbinectomy in endocanalicular laser-assisted endonasal dacryocystorhinostomy? SO: American journal of rhinology & allergy YR: 2011 VL: 25 NO: 4 PG: e160-5 PM: PUBMED 21333092 PT: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/568/CN-00812568/frame.html KY: Dacryocystorhinostomy; Follow-Up Studies; Lacrimal Apparatus [metabolism] [pathology] [surgery]; Lacrimal Apparatus Diseases [diagnosis] [pathology] [physiopathology] [surgery]; Lasers [utilization]; Nasolacrimal Duct [pathology] [surgery]; Prospective Studies; Recovery of Function; Turbinates [pathology] [surgery]; Adult; Aged; Female; Humans; Male; Middle Aged AB: BACKGROUND: This study was designed to compare outcomes of endocanalicular laser-assisted endonasal dacryocystorhinostomy (DCR) with and without partial anterior middle turbinectomy.METHODS: A prospective randomized comparative study was conducted on 91 subjects with primary acquired nasolacrimal duct obstruction, undergoing endocanalicular (ECL) procedures. Group 1 was composed of 44 (7 bilateral) patients undergoing ECL diode laser-assisted endonasal DCR without partial anterior middle turbinectomy and group 2 was composed of 47 (7 bilateral) patients undergoing partial anterior middle turbinectomy and ECL diode laser-assisted endonasal DCR. Follow-up period was 11.0 (6.0-14.5 months) months for group 1 and 9.2 (5.0-14.2 months) months for group 2. Functional success was defined as absence of epiphora and anatomic success was defined as ability to irrigate the lacrimal system. Anatomic and functional success at the 1st week, 3rd month, and final postoperative examinations of two groups were compared using chi-square tests.RESULTS: Final anatomic successes were 39/51 (76%) cases for group 1 and 51/54 (94%) cases for group 2. Final functional successes were 36/51 (%71) patients in group 1 and 48/54 (88%) patients in group 2. Group 2 had higher success at the final examination and the difference was statistically significant.CONCLUSION: We recommend partial anterior middle turbinectomy in all laser ECL laser-assisted endonasal DCR, but further studies with larger sample sizes are needed to strengthen our hypothesis. Record #5 of 15 ID: CN-00751534 AU: Kashkouli MB AU: Pakdel F AU: Hashemi M AU: Ghaempanah MJ AU: Rezaee R AU: Kaghaz-Kanani R AU: Ahadian A TI: Comparing anatomical pattern of topical anti-glaucoma medications associated lacrimal obstruction with a control group. SO: Orbit (Amsterdam, Netherlands) YR: 2010 VL: 29 NO: 2 PG: 65-9 PM: PUBMED 20394542 PT: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't AD: Iran University Eye Research Center, Rassoul Akram Hospital, Tehran, Iran. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/534/CN-00751534/frame.html
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