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V PROGRAM MONDAY, May 17—7:30 PM SESSION 1 OVERVIEW PROGRAM MONDAY, May 17—7:30 PM SESSION 1 OVERVIEW OF EPIGENETICS, CHROMATIN AND TRANSCRIPTION Welcoming Remarks Yi Zhang Howard Hughes Medical Institute University of North Carolina KEYNOTE SPEAKERS Robert Roeder [35’] The Rockefeller University New York, New York “Transcriptional regulatory mechanisms in animal cells” Danny Reinberg [35’] Howard Hughes Medical Institute, NYU School of Medicine, New York, New York. “A molecular understanding of epigenetics” 1 v TUESDAY, May 18—9:00 AM SESSION 2 HISTONE MODIFICATIONS Chairperson: T. Kouzarides, University of Cambridge, Cambridge, United Kingdom Genome-wide profiling of Suv39h targets Inti A. De La Rosa-Velázquez, Borbala Gerle, Ido M. Tamir, Roderick J. O'Sullivan, Andreas Sommer, Carlos F. Pereira, Tatiana Borodina, Hans Lehrach, Amanda G. Fisher, Joost H. Martens, Thomas Jenuwein [25’] Presenter affiliation: Max-Planck-Institute of Immunobiology, Freiburg, Germany; Research Institute of Molecular Pathology, Vienna, Austria. 2 Histone covalent modifications in epigenetic regulation Shelley L. Berger [25’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 3 Gene silencing by an intrinsic inter-assembly of Polycomb-group protein complexes Kyoichi Isono, Haruhiko Koseki [10’] Presenter affiliation: RIKEN, Yokohama, Japan. 4 Linking H3K79 trimethylation to Wnt signaling through a novel Dot1 complex (DotCom) Man Mohan, Hans-Martin Herz, Yoh-Hei Takahashi, Chengqi Lin, Ka Chun Lai, Ying Zhang, Michael P. Washburn, Laurence Florens, Ali Shilatifard [10’] Presenter affiliation: Stowers Institute for Medical Research, Kansas City, Missouri. 5 Signaling to and through chromatin Kenneth E. Lee, Tamaki Suganuma, Selene Swanson, Laurence Florens, Michael P. Washburn, Jerry L. Workman [25’] Presenter affiliation: Stowers Institute, Kansas City, Missouri. 6 Histone demethylases—Mechanism of action and connection to mental retardation Yang Shi [25’] Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 7 vi Polycomb and Thrithorax regulate MADS-family transcription factor genes to ensure plant reproduction Alexandre Berr, Rozenn Ménard, Emily J. McCallum, Sarfraz Shafiq, Juan Gao, Denise Meyer, Aiwu Dong, Wen-Hui Shen [10’] Presenter affiliation: IBMP-CNRS, Strasbourg, France. 8 TDRD3 is an effector molecule for Arginine methylated histone marks Yanzhong Yang, Mark T. Bedford [10’] Presenter affiliation: M.D. Anderson Cancer Center, Smithville, Texas. 9 TUESDAY, May 18—2:00 PM SESSION 3 POSTER SESSION I Cell-to-cell variation in the aging transcriptome Pauline Abdallah, Brent Calder, Masako Suzuki, John M. Greally, Jan Vijg Presenter affiliation: Albert Einstein College of Medicine, Bronx, New York. 10 Epigenetic regulation of microRNAs in embryonic stem cells Monther Abu-Remaileh, Shari Orlanski, Yoichi Shinkai, Carlo Croce, Howard Cedar, Yehudit Bergman Presenter affiliation: Hebrew University of Jerusalem, Israel. 11 True methylation analysis of promoters using novel assays for detection of methylated and non-methylated DNA Luis G. Acevedo, Ana Sanz Presenter affiliation: Active Motif, Inc., Carlsbad, California. 12 How is epigenetic control of the Plasmodium falciparum malaria parasite erythrocyte adhesion antigens exerted? David E. Arnot, Louise Joergensen, Dominique C. Bengtsson, Elena Ronander, Anja T. Jensen Presenter affiliation: University of Copenhagen, Copenhagen, Denmark. 13 An oncogenic chromosomal translocation subverts the activity of the Tip60 complex and mistargets its HAT activity to normally repressed genes Nikita Avvakumov, Jacques Côté Presenter affiliation: Université Laval, Québec, Canada. 14 vii The transcriptional intermediary factor TIF1γ controls erythroid cell fate by regulating transcriptional elongation Xiaoying Bai, Jonghwan Kim, Zhongan Yang, Michael J. Jurynec, Joseph Lee, Jocelyn LeBlanc, Anna Sessa, Thomas E. Akie, Alan B. Cantor, Shuo Lin, Stuart H. Orkin, Leonard I. Zon Presenter affiliation: HHMI/Children's Hospital Boston, Boston, Massachusetts; Children's Hospital Boston, Boston, Massachusetts. 15 Regulation of Mec1/ATR activity through a chromatin remodeling complex Yunhe Bao, Xuetong Shen Presenter affiliation: MD Anderson Cancer Center, Smithville, Texas. 16 The role of REST as a transcriptional and epigenetic regulator Angela Bithell, Chiara Soldati, Jasmine De Cock, Noel J. Buckley Presenter affiliation: King's College London, Institute of Psychiatry, London, United Kingdom. 17 AF4 is a critical regulator of the IGF-1 signalling pathway for maintenance of mature Purkinje cell function and survival Emmanuelle Bitoun, Mattea Finelli, Peter L. Oliver, Sheena Lee, Kay E. Davies Presenter affiliation: MRC Functional Genomics Unit, Oxford, United Kingdom. 18 Transcriptional and epigenetic signatures of multipotent neural stem cells and astrocytes Alessandro Michelucci, Angela Bithell, Caroline E. Johnston, Kee-Yew Wong, Lawrence W. Stanton, Noel J. Buckley Presenter affiliation: King's Colllege London, London, United Kingdom. 19 NRIP enhances HPV-E2 transcription activity in a Ca+2/CaM- dependent pathway Szu-Wei Chang, Show-Li Chen Presenter affiliation: Graduate Institute of Microbiology, Taipei, Taiwan. 20 Coordinated regulation of active and repressive histone methylations by a dual specificity histone demethylase ceKDM7A from C. elegans Hanqing Lin, Charlie Degui Chen Presenter affiliation: Shanghai Institutes for Biological Sciences, Shanghai, China. 21 viii Autophagy potentiates the anticancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma Ching-Chow Chen Presenter affiliation: College of Medicine, National Taiwan University, Taipei, Taiwan. 22 The dynamics of Pol II stalling in Drosophila development Kai Chen, Yu Jiang, Jeffrey Johnston, Björn Gärtner, Qiye He, Julia Zeitlinger Presenter affiliation: Stowers Institute for Medical Research, Kansas City, Missouri. 23 Yeast Rpd3S exhibits nucleosome assembly activity Xiao-Fen Chen, Benjamin Kuryan, Bing Li, Michael Carey Presenter affiliation: University of California, Los Angeles, Los Angeles, California. 24 The histone chaperone Nap1 mediates nucleosome assembly through disassembly of non-nucleosomal chromatin in yeast Xu Chen, Karolin Luger, Laurie A. Stargell Presenter affiliation: Colorado State University, Fort Collins, Colorado. 25 Functional elements in the regulation of IGF1 expression Holly Y. Chen, Wei Huang Presenter affiliation: The Chinese University of Hong Kong, Shatin, Hong Kong. 26 Structure and function of the specificity of a novel histone demethylase PHF8 Lin Yu, Yang Wang, Shuo Huang, Weimin Gong, Pinchao Mei, Zhongzhou Chen Presenter affiliation: State Key Laboratory of Agrobiotechnology, Beijing, China. 27 BEADS—A bias elimination algorithm for deep sequencing data Ming-Sin Cheung, Thomas Down, Julie Ahringer Presenter affiliation: The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, United Kingdom. 28 Epigenetic inactivation of the miR-34a in hematological malignancies CS Chim, KY Wong Presenter affiliation: Queen Mary Hospital, Hong Kong, China. 29 ix TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT Jee-Hye Choi, Na Young Min, Young Jong Ko, Jae Oh Song, Ae Ja Park, Kwang-Ho Lee Presenter affiliation: Chung-Ang University, Seoul, South Korea. 30 Genome-wide mapping of interacting sequences of long non- coding RNAs with chromatin modifying complexes Ci Chu, Howard Chang Presenter affiliation: Stanford University, Stanford, California. 31 Chromosome instability and epigenetic changes in drug acquired resistance Llorenç Coll-Mulet, Cristina Morales, Miguel A. Peinado Presenter affiliation: IMPPC, Badalona, Spain. 32 BAF Chromatin-remodeling complex Kairong Cui, Daniel Northrup, Dustin E. Schones, Keji Zhao Presenter affiliation: Laboratory of Molecular Immunology, Bethesda, Maryland. 33 The role of Alu repeats embedded in active chromatin domains Joaquin Custodio, Berta Martín, Sergio Lois, Victor Barrera, Miguel Angel Peinado, Mireia Jordà Presenter affiliation: IMPPC, Badalona, Spain. 34 The plant Trithorax-like Factor ATX1 is required for dehydration tolerance and interacts with RNA polymerase II Yong Ding, Zoya Avramova, Michael Fromm Presenter affiliation: University of Nebraska-Lincoln, Lincoln, Nebraska. 35 NAP1-Related Protein (NRP) activates gene transcription by nucleosome disassembly in Arabidopsis thaliana Yan Zhu, Aiwu Dong Presenter affiliation: Fudan University, Shanghai, China. 36 Global epigenetic profiling in bladder cancer Ewa Dudziec, Wei Chen, Freddie C. Hamdy, James W. Catto Presenter affiliation: The University of Sheffield, Sheffield, United Kingdom. 37 x Casein kinase 2 dependent phosphorylation of Histone deacetylase 2 mediates cardiac hypertrophy Gwang Hyeon Eom, Jeong Hyeon Ko, Young Kuk Cho, Nakwon Choe, Hae Jin Kee, Hyun Kook Presenter affiliation: Chonnam National University Medical School, Gwangju, South Korea. 38 Nucleosome depletion in yeast terminator regions is limited and not intrinsically determined Xiaochun Fan, Zarmik Moqtaderi, Yi Jin, Yong Zhang, Shirley X. Liu, Kevin Struhl Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 39 New factors in chromatin replication Yunpeng Feng, Jakob Mejlvang, Xiaobei Zhao, Constance Alabert, Albin Sandelin, Anja Groth Presenter affiliation: Biotech Research & Innovation Centre (BRIC), Copenhagen University, Copenhagen, Denmark. 40 Studying the DNA repair pathways involved in DNA demethylation Don-Marc Franchini,
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