PROGRAM
MONDAY, May 17—7:30 PM
SESSION 1 OVERVIEW OF EPIGENETICS, CHROMATIN AND TRANSCRIPTION
Welcoming Remarks
Yi Zhang Howard Hughes Medical Institute University of North Carolina
KEYNOTE SPEAKERS
Robert Roeder [35’] The Rockefeller University New York, New York
“Transcriptional regulatory mechanisms in animal cells”
Danny Reinberg [35’] Howard Hughes Medical Institute, NYU School of Medicine, New York, New York.
“A molecular understanding of epigenetics” 1
v TUESDAY, May 18—9:00 AM
SESSION 2 HISTONE MODIFICATIONS
Chairperson: T. Kouzarides, University of Cambridge, Cambridge, United Kingdom
Genome-wide profiling of Suv39h targets Inti A. De La Rosa-Velázquez, Borbala Gerle, Ido M. Tamir, Roderick J. O'Sullivan, Andreas Sommer, Carlos F. Pereira, Tatiana Borodina, Hans Lehrach, Amanda G. Fisher, Joost H. Martens, Thomas Jenuwein [25’] Presenter affiliation: Max-Planck-Institute of Immunobiology, Freiburg, Germany; Research Institute of Molecular Pathology, Vienna, Austria. 2
Histone covalent modifications in epigenetic regulation Shelley L. Berger [25’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 3
Gene silencing by an intrinsic inter-assembly of Polycomb-group protein complexes Kyoichi Isono, Haruhiko Koseki [10’] Presenter affiliation: RIKEN, Yokohama, Japan. 4
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1 complex (DotCom) Man Mohan, Hans-Martin Herz, Yoh-Hei Takahashi, Chengqi Lin, Ka Chun Lai, Ying Zhang, Michael P. Washburn, Laurence Florens, Ali Shilatifard [10’] Presenter affiliation: Stowers Institute for Medical Research, Kansas City, Missouri. 5
Signaling to and through chromatin Kenneth E. Lee, Tamaki Suganuma, Selene Swanson, Laurence Florens, Michael P. Washburn, Jerry L. Workman [25’] Presenter affiliation: Stowers Institute, Kansas City, Missouri. 6
Histone demethylases—Mechanism of action and connection to mental retardation Yang Shi [25’] Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 7
vi Polycomb and Thrithorax regulate MADS-family transcription factor genes to ensure plant reproduction Alexandre Berr, Rozenn Ménard, Emily J. McCallum, Sarfraz Shafiq, Juan Gao, Denise Meyer, Aiwu Dong, Wen-Hui Shen [10’] Presenter affiliation: IBMP-CNRS, Strasbourg, France. 8
TDRD3 is an effector molecule for Arginine methylated histone marks Yanzhong Yang, Mark T. Bedford [10’] Presenter affiliation: M.D. Anderson Cancer Center, Smithville, Texas. 9
TUESDAY, May 18—2:00 PM
SESSION 3 POSTER SESSION I
Cell-to-cell variation in the aging transcriptome Pauline Abdallah, Brent Calder, Masako Suzuki, John M. Greally, Jan Vijg Presenter affiliation: Albert Einstein College of Medicine, Bronx, New York. 10
Epigenetic regulation of microRNAs in embryonic stem cells Monther Abu-Remaileh, Shari Orlanski, Yoichi Shinkai, Carlo Croce, Howard Cedar, Yehudit Bergman Presenter affiliation: Hebrew University of Jerusalem, Israel. 11
True methylation analysis of promoters using novel assays for detection of methylated and non-methylated DNA Luis G. Acevedo, Ana Sanz Presenter affiliation: Active Motif, Inc., Carlsbad, California. 12
How is epigenetic control of the Plasmodium falciparum malaria parasite erythrocyte adhesion antigens exerted? David E. Arnot, Louise Joergensen, Dominique C. Bengtsson, Elena Ronander, Anja T. Jensen Presenter affiliation: University of Copenhagen, Copenhagen, Denmark. 13
An oncogenic chromosomal translocation subverts the activity of the Tip60 complex and mistargets its HAT activity to normally repressed genes Nikita Avvakumov, Jacques Côté Presenter affiliation: Université Laval, Québec, Canada. 14
vii The transcriptional intermediary factor TIF1γ controls erythroid cell fate by regulating transcriptional elongation Xiaoying Bai, Jonghwan Kim, Zhongan Yang, Michael J. Jurynec, Joseph Lee, Jocelyn LeBlanc, Anna Sessa, Thomas E. Akie, Alan B. Cantor, Shuo Lin, Stuart H. Orkin, Leonard I. Zon Presenter affiliation: HHMI/Children's Hospital Boston, Boston, Massachusetts; Children's Hospital Boston, Boston, Massachusetts. 15
Regulation of Mec1/ATR activity through a chromatin remodeling complex Yunhe Bao, Xuetong Shen Presenter affiliation: MD Anderson Cancer Center, Smithville, Texas. 16
The role of REST as a transcriptional and epigenetic regulator Angela Bithell, Chiara Soldati, Jasmine De Cock, Noel J. Buckley Presenter affiliation: King's College London, Institute of Psychiatry, London, United Kingdom. 17
AF4 is a critical regulator of the IGF-1 signalling pathway for maintenance of mature Purkinje cell function and survival Emmanuelle Bitoun, Mattea Finelli, Peter L. Oliver, Sheena Lee, Kay E. Davies Presenter affiliation: MRC Functional Genomics Unit, Oxford, United Kingdom. 18
Transcriptional and epigenetic signatures of multipotent neural stem cells and astrocytes Alessandro Michelucci, Angela Bithell, Caroline E. Johnston, Kee-Yew Wong, Lawrence W. Stanton, Noel J. Buckley Presenter affiliation: King's Colllege London, London, United Kingdom. 19
NRIP enhances HPV-E2 transcription activity in a Ca+2/CaM- dependent pathway Szu-Wei Chang, Show-Li Chen Presenter affiliation: Graduate Institute of Microbiology, Taipei, Taiwan. 20
Coordinated regulation of active and repressive histone methylations by a dual specificity histone demethylase ceKDM7A from C. elegans Hanqing Lin, Charlie Degui Chen Presenter affiliation: Shanghai Institutes for Biological Sciences, Shanghai, China. 21
viii Autophagy potentiates the anticancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma Ching-Chow Chen Presenter affiliation: College of Medicine, National Taiwan University, Taipei, Taiwan. 22
The dynamics of Pol II stalling in Drosophila development Kai Chen, Yu Jiang, Jeffrey Johnston, Björn Gärtner, Qiye He, Julia Zeitlinger Presenter affiliation: Stowers Institute for Medical Research, Kansas City, Missouri. 23
Yeast Rpd3S exhibits nucleosome assembly activity Xiao-Fen Chen, Benjamin Kuryan, Bing Li, Michael Carey Presenter affiliation: University of California, Los Angeles, Los Angeles, California. 24
The histone chaperone Nap1 mediates nucleosome assembly through disassembly of non-nucleosomal chromatin in yeast Xu Chen, Karolin Luger, Laurie A. Stargell Presenter affiliation: Colorado State University, Fort Collins, Colorado. 25
Functional elements in the regulation of IGF1 expression Holly Y. Chen, Wei Huang Presenter affiliation: The Chinese University of Hong Kong, Shatin, Hong Kong. 26
Structure and function of the specificity of a novel histone demethylase PHF8 Lin Yu, Yang Wang, Shuo Huang, Weimin Gong, Pinchao Mei, Zhongzhou Chen Presenter affiliation: State Key Laboratory of Agrobiotechnology, Beijing, China. 27
BEADS—A bias elimination algorithm for deep sequencing data Ming-Sin Cheung, Thomas Down, Julie Ahringer Presenter affiliation: The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, United Kingdom. 28
Epigenetic inactivation of the miR-34a in hematological malignancies CS Chim, KY Wong Presenter affiliation: Queen Mary Hospital, Hong Kong, China. 29
ix TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT Jee-Hye Choi, Na Young Min, Young Jong Ko, Jae Oh Song, Ae Ja Park, Kwang-Ho Lee Presenter affiliation: Chung-Ang University, Seoul, South Korea. 30
Genome-wide mapping of interacting sequences of long non- coding RNAs with chromatin modifying complexes Ci Chu, Howard Chang Presenter affiliation: Stanford University, Stanford, California. 31
Chromosome instability and epigenetic changes in drug acquired resistance Llorenç Coll-Mulet, Cristina Morales, Miguel A. Peinado Presenter affiliation: IMPPC, Badalona, Spain. 32
BAF Chromatin-remodeling complex Kairong Cui, Daniel Northrup, Dustin E. Schones, Keji Zhao Presenter affiliation: Laboratory of Molecular Immunology, Bethesda, Maryland. 33
The role of Alu repeats embedded in active chromatin domains Joaquin Custodio, Berta Martín, Sergio Lois, Victor Barrera, Miguel Angel Peinado, Mireia Jordà Presenter affiliation: IMPPC, Badalona, Spain. 34
The plant Trithorax-like Factor ATX1 is required for dehydration tolerance and interacts with RNA polymerase II Yong Ding, Zoya Avramova, Michael Fromm Presenter affiliation: University of Nebraska-Lincoln, Lincoln, Nebraska. 35
NAP1-Related Protein (NRP) activates gene transcription by nucleosome disassembly in Arabidopsis thaliana Yan Zhu, Aiwu Dong Presenter affiliation: Fudan University, Shanghai, China. 36
Global epigenetic profiling in bladder cancer Ewa Dudziec, Wei Chen, Freddie C. Hamdy, James W. Catto Presenter affiliation: The University of Sheffield, Sheffield, United Kingdom. 37
x Casein kinase 2 dependent phosphorylation of Histone deacetylase 2 mediates cardiac hypertrophy Gwang Hyeon Eom, Jeong Hyeon Ko, Young Kuk Cho, Nakwon Choe, Hae Jin Kee, Hyun Kook Presenter affiliation: Chonnam National University Medical School, Gwangju, South Korea. 38
Nucleosome depletion in yeast terminator regions is limited and not intrinsically determined Xiaochun Fan, Zarmik Moqtaderi, Yi Jin, Yong Zhang, Shirley X. Liu, Kevin Struhl Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 39
New factors in chromatin replication Yunpeng Feng, Jakob Mejlvang, Xiaobei Zhao, Constance Alabert, Albin Sandelin, Anja Groth Presenter affiliation: Biotech Research & Innovation Centre (BRIC), Copenhagen University, Copenhagen, Denmark. 40
Studying the DNA repair pathways involved in DNA demethylation Don-Marc Franchini, Svend K. Petersen-Mahrt Presenter affiliation: Cancer Research UK, South Mimms, United Kingdom. 41
H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis Lifeng Wang, Kai Ge Presenter affiliation: NIDDK, National Institutes of Health, Bethesda, Maryland. 42
Nutritional impact of folic acid on the human epigenome Qiaoning Guan, Jasper Rine Presenter affiliation: University of California, Berkeley, Berkeley, California. 43
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells Matthew G. Guenther, Garrett M. Frampton, Frank Soldner, Dirk Hockemeyer, Rudolf Jaenisch, Richard A. Young Presenter affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts. 44
xi Using ChIP-chip and ChIP-seq to analyze epigenetic regulation of transcription, development and aging Jing-Dong J. Han Presenter affiliation: Chinese Academy of Sciences, Beijing, China. 45
Evolution of cis-regulation in Arabidopsis Fei He, Xu Zhang, Jinyong Hu, Tina Hu, Magnus Nordborg, Ulrike Goebel, Justin Borevitz, Juliette de Meaux Presenter affiliation: Max Planck Institute for Plant Breeding Research, Cologne, Germany. 46
Ras-mediated regional silencing around Fas gene locus Masaki Hosogane, Ryo Funayama, Keiko Nakayama Presenter affiliation: Tohoku University Graduate School of Medicine, Sendai, Japan; CREST, Kawaguchi, Japan. 47
HPV E6 represses p53 transcriptional activity and stability via inhibition of distinct histone methyltransferases Chih-Hung Hsu, Kai-Lin Peng, Hua-Ci Jhang, Chia-Hui Lin, Shwu-Yuan Wu, Cheng-Ming Chian, Sheng-Chung Lee, Cheng-Wen Wu, Li-Jung Juan Presenter affiliation: Academia Sinica, Taipei, Taiwan. 48
MeCP2 Ser80 phosphorylation is regulated in mitosis checkpoint Keping Hu, Weidong Wang Presenter affiliation: CAMS/PUMC, Beijing, China; NIA, National Institutes of Health, Baltimore, Maryland. 49
The role of a double-bromodomain protein in deciphering a novel subcellular code Der-Hwa Huang Presenter affiliation: Institute of Molecular Biology, Taipei, Taiwan. 50
An intragenic non-coding RNA modulates expression of ASP3 in budding yeast Yu-Ching Huang, Hung-Ta Chen, Shu-Chun Teng Presenter affiliation: College of Medicine, National Taiwan University, Taipei, Taiwan. 51
Interaction of de novo DNA methyltransferase with chromatin determines the methylation specificity Zheng Huang, Bin-Zhong Li, Xue-Hui Song, Guo-Liang Xu Presenter affiliation: The State Key Laboratory of Molecular Biology, Shanghai, China. 52
xii New insights from an ex vivo model of Pit-1-mediated chromatin modification and cofactor recruitment in the activation of the human growth hormone gene by a distal locus control region Tamra L. Hunsaker, Brian M. Shewchuk Presenter affiliation: Brody School of Medicine at East Carolina University, Greenville, North Carolina. 53
Epigenetic regulation of neuronal genes expression in mesenchymal stem cells Praewphan Ingrungruanglert, Nipan Israsena Presenter affiliation: Chulalongkorn University, Bangkok, Thailand. 54
Tip60 increases transcriptional activity of NF-kappaB/p65 through protein-protein interaction Sang-Min Jang, Jung-Woong Kim, Chul-Hong Kim, Young-Dae Park, Kyung-Hee Choi Presenter affiliation: Chung-Ang University, Seoul, South Korea. 55
A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome Cizhong Jiang, Frank Pugh Presenter affiliation: Tongji University, Shanghai, China. 56
A plant-specific histone H3 lysine-4 demethylase represses the developmental switch from a vegetative to a reproductive phase Wannian Yang, Danhua Jiang, Jiafu Jiang, Yuehui He Presenter affiliation: National University of Singapore, Singapore. 57
HP1-mediated formation of alternative lengthening of telomeres- associated PML bodies requires HIRA Wei-Qin Jiang, Akira Nguyen, Andy Chang, Roger Reddel Presenter affiliation: Children's Medical Research Institute, Westmead, Sydney, Australia. 58
Elk-1-mediated RBP2 overexpression contributes to lung tumorigenesis and invasiveness Li-Jung Juan Presenter affiliation: Genomics Research Center, Taipei, Taiwan. 59
Epigenetic regulation of embryonic stem cell proliferation and lineage specific differentiation Felix Lohmann, Joseph Loureiro, Hong Lei, Yi Yang, Peter Finan, En Li, Taiping Chen, Shilpa Kadam Presenter affiliation: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts. 60
xiii The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity Ferdinand Kappes, Tanja Waldmann, Veena Mathew, Jindan Yu, Michael S. Khodadoust, Arul M. Chinnaiyan, Sylvia Erhardt, Robert Schneider, David M. Markovitz Presenter affiliation: University of Michigan Medical School, Ann Arbor, Michigan. 61
Placental defects in embryos following paternal tamoxifen treatment Neelam A. Kedia Mokashi, Shilpa G. Pathak, Nafisa H. Balasinor Presenter affiliation: National Institute for Research in Reproductive Health, Mumbai, India. 62
Identification and characterization of the MMTR/DMAP1 target genes in the mouse embryonic stem cells Jinseon Jeon, Dae Hyun Ha, Won Kim, Ji Hyung Chae, Tae-Young Roh, Chul Geun Kim Presenter affiliation: Hanyang University, Seoul, South Korea. 63
Lysine methylation-dependent ubiquitination of orphan nuclear receptor Ik Soo Kim, Ji Min Lee, Keun Il Kim, Sung Hee Baek Presenter affiliation: Seoul National University, Seoul, South Korea. 64
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS Jaehoon Kim, Mohamed Guermah, Robert G. Roeder Presenter affiliation: The Rockefeller University, New York, New York. 65
The putative role of JMJD1B in leukemia which demethylates histone H3K9 mono- and di-methylation Ji-Young Kim, Nak-Won Choe, Kee-Beom Kim, Jin-Ee Seol, Sul-Ji Choi, Hae Jin Kee, Yoonsoo Hahn, Hyun Kook, Sang-Beom Seo Presenter affiliation: Chung-Ang University, Seoul, South Korea. 66
Tip60 regulates the transcriptional activity of neural retina leucine-zipper (Nrl) via JNK1-mediated phosphorylation in mouse retinogenesis Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Young-Dae Park, Kyung-Hee Choi Presenter affiliation: Chung-Ang University, Seoul, South Korea. 67
xiv Genome-wide localization of histone H3 methylation reveals molecular crosstalk between histone H3K79 di-methylation and transcription elongation in human stem cells Seung-Kyoon Kim, Inkyung Jung, Mirang Kim, Daeyoup Lee Presenter affiliation: Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 68
G9a methyltransferase-mediated methylation of a Reptin Chromatin-remodeling complex in cancer Yunho Kim, Jason S. Lee, Sung Hee Baek Presenter affiliation: Seoul National University, Seoul, South Korea. 69
Shared function between the NuA4 and SWR1 complexes Nancy Lévesque, Michael S. Kobor Presenter affiliation: University of British Columbia, CMMT, Vancouver, Canada. 70
Inhibition of class IIb histone deacetylase leads the significant improvement of cloning efficiency in mice Tetsuo Ono, Chong Li, Eiji Mizutani, Teruhiko Wakayama Presenter affiliation: RIKEN, Center for Developmental Biology, Kobe, Japan; Kwansei Gakuin University, Sanda, Japan. 71
Long- and short-range transcriptional repressors induce distinct chromatin states on repressed genes Li Li, David N. Arnosti Presenter affiliation: Michigan State University, East Lansing, Michigan. 72
Epigenome sequencing comes of age in development, differentiation and diseases mechanism researches Ning Li Presenter affiliation: Beijing Genomics Institute, Shenzhen, China. 73
PAD4 coordinates with HDAC2 in the regulation of p53-target gene expression and is a promising drug target for cancer therapy Pingxin Li, Yuji Wang, Shu Wang, Jing Hu, Gong Chen, Yanming Wang Presenter affiliation: Pennsylvania State University, University Park, Pennsylvania. 74
xv Rtt106 binds and deposits (H3-H4)2 tetramers onto replicating DNA Qing Li, A. M. Fazly, Dan Su, Qi Hu, Georges Mer, Zhiguo Zhang Presenter affiliation: Mayo Clinic College of Medicine, Rochester, Minnesota. 75
KAP1/Trim28/TIF1β facilitates the interaction between ZFP57 and DNA methyltransferases Jipo Sheng, Xiaopan Zuo, Monica Andrade, Michelina Iacovino, Michael Kyba, Guoliang Xu, Xiajun Li Presenter affiliation: Mount Sinai School of Medicine, New York, New York. 76
Locus-specific control of DNA methylation at mouse SINE B1 elements by the Dnmt3 family during male germ cell development Yufeng Li, Kenji Ichiyanagi, Junko Kitayama, Hiroyuki Sasaki Presenter affiliation: National Institute of Genetics, Mishima, Japan. 77
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1 Chung-Yi Liang, Dai-Fang Chou, Chao-Yu Pan, Wan-Sheng Lo Presenter affiliation: Institute of Plant and Microbial Biology, Taipei, Taiwan; Institute of Biochemistry and Molecular Biology, Taipei, Taiwan. 78
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the Met oncogene in bladders with cancer Gangning Liang, Erika M. Wolff, Hyany-Min Byun, Han F. Han, Shikhar Sharma, Peter A. Jones Presenter affiliation: USC/Norris Comprehensive Cancer Center, Los Angeles, California. 79
A tryptophan-rich transcription activation domain functioning in yeast Chen-Huan Lin, Yu-Ju Cheng, Chih-Chi Liao, Chien-Chia Wang Presenter affiliation: National Central University, Jung-li, Taiwan. 80
Genome-wide association of O-Acetyl-ADP-ribose with chromatin Shu-Yun Tung, Danesh Moazed, Gunn-Guang Liou Presenter affiliation: National Health Research Institutes, Miaoli, Taiwan. 81
xvi Arabidopsis protein arginine methyltransferase AtPRMT5 is involved in regulating pre-mRNA splicing Xian Deng, Lianfeng Gu, Chunyan Liu, Xiaofeng Cao Presenter affiliation: State Key Laboratory of Plant Genomics and Center for Genome Biology, Beijing, China. 82
Whether a valid assumption—The same total amount of gene expressions between cells/individuals/species under the same condition Fu-Guo R. Liu, Tzi-Yuan Wang, Huang-Mo Sung, Wen-Hsiung Li Presenter affiliation: National Central University, Jhongli City, Taiwan. 83
A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length Ning-Ning Liu, Tian-Xu Han, Jin-Qiu Zhou, Li-Lin Du Presenter affiliation: The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai, China. 84
The elevated ambient temperatures trigger significant epigenetic responses in Arabidopsis thaliana Qiong A. Liu, Will Liao, Patrick May, Michael Q. Zhang Presenter affiliation: Brookhaven National Lab, New York, New York. 85
Up-regulation of SIRT1 stabilizes N-Myc protein and promotes N- Myc oncogenesis Tao Liu, Glenn M. Marshall, Pei Y. Liu, Samuele Gherardi, Christopher J. Scarlett, Antionio Bedalov, Murray D. Norris, Michelle Haber, Andrew V. Biankin, Giovanni Perini Presenter affiliation: University of New South Wales, Kensington, Australia. 86
TUESDAY, May 18—4:30 PM
Chinese Tea and Beer Tasting
xvii TUESDAY, May 18—7:30 PM
SESSION 4 DNA METHYLATION AND TRANSCRIPTION REGULATION
Chairperson: J. Workman, Stowers Institute for Medical Research, Kansas City, Missouri, USA
Control of DNA methylation through chromatin in Neurospora Eric U. Selker, Shinji Honda, Keyur K. Adhvaryu, Zachary A. Lewis [25’] Presenter affiliation: University of Oregon, Eugene, Oregon. 87
En Li [25’] Presenter affiliation: Novartis Institutes for Biomedical Research, Shanghai, China.
Short RNAs are transcribed from repressed Polycomb target genes and interact with Polycomb Repressive Complex-2 Aditi Kanhere, Keijo Viiri, Carla C. Araujo, Jane Rasaiyaah, Russell D. Bouwman, Warren A. Whyte, Filipe Pereira, Emily Brookes, Ana Pombo, Amanda G. Fisher, Richard A. Young, Richard G. Jenner [10’] Presenter affiliation: University College London, United Kingdom. 88
Single-cell epigenomics Silvia Gravina, John Greally, Masako Suzuki, Jan Vijg [10’] Presenter affiliation: Albert Einstein College of Medicine, Bronx, New York. 89
Could the DNA demethylase please stand up? Yi Zhang [25’] Presenter affiliation: I/University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 90
Active DNA demethylation in Arabidopsis Jian-Kang Zhu [25’] Presenter affiliation: King Abdullah University of Science and Technology, Thuwal, Saudi Arabia; University of California, Riverside, California. 91
xviii Epigenetic regulation of imprinting, reprogramming, and lineage commitment in mammals W. Reik, C. Popp, G. Ficz, M. Branco, C. Krueger, S. Andrews, M. Hemberger, W. Dean [25’] Presenter affiliation: The Babraham Institute, Cambridge, United Kingdom; University of Cambridge, Cambridge, United Kingdom. 92
WEDNESDAY, May 19—9:00 AM
SESSION 5 HETEROCHROMATIN AND sncRNAs
Chairperson: R. Shiekhattar, Wistar Institute, Philadelphia, Pennsylvania, USA
Copying and reprogramming of heterochromatin with RNAi Keith Slotkin, Milos Tanurdzic, Matt Vaughn, Mikel Zaratiegui, Danielle Irvine, Anna Kloc, J-P Vielle Calzada, R. W. Doerge, Rob Martienssen [25’] Presenter affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. 93
Three RNA polymerases in small RNA-based epigenetic regulation in Arabidopsis Xuemei Chen [25’] Presenter affiliation: University of California, Riverside, Riverside, California. 94
Epigenetic genome control by heterochromatin and RNAi machinery Shiv I. Grewal [25’] Presenter affiliation: National Institutes of Health, Bethesda, Maryland. 95
Epigenetic inheritance in fission yeast Fei Li, Rob Martienssen, W. Zacheus Cande [10’] Presenter affiliation: University of California at Berkeley, Berkeley, California. 96
A novel epigenetic mechanism in Drosophila somatic cells mediated by PIWI and piRNAs Haifan Lin [25’] Presenter affiliation: Yale University, New Haven, Connecticut. 97
xix Role for PIWI-interacting RNA and a novel noncoding RNA in de novo DNA methylation of the imprinted mouse RasGRF1 locus in the mouse germline Hiroyuki Sasaki, Toshiaki Watanabe [25’] Presenter affiliation: Kyushu University Medical Institute of Bioregulation, Fukuoka, Japan; Research Organization of Information and Systems, Mishima, Japan. 98
RNAi by the numbers—Explaining biology through enzymology Liang Meng Wee, Phillip D. Zamore [10’] Presenter affiliation: Howard Hughes Medical Institute and UMASS Medical School, Worcester, Massachusetts. 99
WEDNESDAY, May 19—1:30 PM
SESSION 6 POSTER SESSION II
Arginine methylation activity is essential for AtPRMT10 in flowering time regulation Falong Lu, Lifang Niu, Taolan Zhao, Chunyan Liu, Xiaofeng Cao Presenter affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. 100
The regulation of muscle miRNAs by YY1 in skeletal myogenesis leina Lu, Eric Z. Chen, Hao Sun, Huating Wang Presenter affiliation: Chinese University of Hong Kong, Hong Kong, China. 101
Genome-wide analysis of gamma H2X upon cellular senescence of human adult mesenchymal stem cells Glenn Geesman, Sirkka L. Hostikka, Benjamin Blackwell, Michelle Atallah, Victoria V. Lunyak Presenter affiliation: The Buck Institute for Age Research, Novato, California. 102
Investigating the role of heterochromatin protein1α in signalling events mediated by perturbations on the tail of core histone H3 Shashwath K. Malli, Shabir A. Ganai, Sowdhamini Ramanathan, Vijayalakshmi Mahadevan Presenter affiliation: SASTRA University, Thanjavur, India. 103
xx MLL histone methylases in estrogen-mediated HOX gene expression and disease Subhrangsu S. Mandal, Khairul I. Ansari, Sahba Kasiri, Imran Hussain, Bishakha Shrestha Presenter affiliation: The University of Texas at Arlington, Arlington, Texas. 104
The dual H3 K79me3/pT80 modification is a novel mitosis- associated histone mark Danielle R. Martinez, Hunter Richards, Jonathan Curry, Estela E. Medrano Presenter affiliation: Baylor College of Medicine, Houston, Texas. 105
Expression of Aire, a histone-binding module for H3K4me0, in ES cell Mitsuru Matsumoto, Yumiko Nishikawa Presenter affiliation: Institute for Enzyme Research, Tokushima, Japan. 106
Translocation of p53 into nucleus is modulated by dynamic change of vimentin against EGCG treatment in human cancer cells Na Young Min, Jee-Hye Choi, Jin Hong Kim, Lkhagvasuren Gavaachimed, Ae Ja Park, Kwang-Ho Lee Presenter affiliation: Chung-Ang University, Seoul, South Korea. 107
DNA demethylation regulates primordial germ cell-specific gene expression in mouse Kentaro Mochizuki, Yasuhisa Matsui Presenter affiliation: Tohoku University, Aoba-ku, Sendai, Japan. 108
CTCF and Cohesin form a primary chromatin conformation scaffold and a docking station for transcription factors Adele Murrell, Raffaella Nativio, Yoko Ito Presenter affiliation: University of Cambridge, Cambridge, United Kingdom. 109
LINE-1 retrotransposon hypomethylation in cancer represses transcription Apiwat Mutirangura, Chatchawit Aporntewan, Chupong Ittiwut, Chureerat Phokaew, Jittima Piriyapongsa, Sissades Tongsima Presenter affiliation: Chulalongkorn University, Bangkok, Thailand. 110
xxi Histone H2A variant dynamics during preimplantation development in mice Buhe Nashun, Masashi Yukawa, Honglin Liu, Tomohiko Akiyama, Fugaku Aoki Presenter affiliation: University of Tokyo, Kashiwa, Japan. 111
Deciphering and reconstructing the embryonic stem cell transcriptional regulatory network Huck-Hui Ng Presenter affiliation: Genome Institute of Singapore, Singapore. 112
A role of histone methylation by ASH1L in the establishment of transcriptional memory Ken Higashimoto, Yukari Yada, Toshiharu Komori, Masashi Matsuda, Yoko Koseki, Manabu Nakayama, Hidenobu Soejima, Hiroshi Handa, Haruhiko Koseki, Susumu Hirose, Kenichi Nishioka Presenter affiliation: Saga University, Saga City, Japan; National Institute of Genetics, Mishima City, Japan; Japan Science and Technology Agency, Kawaguchi City, Japan. 113
Both the insulator and essential functions of Cp190 require the BTB/POZ domain and two acidic regions, but not the zinc fingers or centrosomal association domains Chi-Yun Pai, Daniel Oliver, Heather South, Brian Sheehan Presenter affiliation: University of Nevada, Reno, Nevada. 114
The YY1 REPO domain needed for PcG function is necessary for B cell development and interacts with condensin proteins to regulate Ig rearrangement. Xuan Pan, Yi Hao, William Quinn, Marco Calamito, Fang Wei, Junwen Wang, Yang Shi, David Allman, Michael Cancro, Michael Atchison Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 115
Yeast Mediator complex plays a role in telomere chromatin regulation Jing Peng, Ping-Li Mo, Jin-Qiu Zhou Presenter affiliation: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. 116
Structure of NSD1 reveals an autoregulatory mechanism of the H3K36 histone methyltransferase Qi Qiao, Yan Li, Mingzhu Wang, Zhi Chen, Danny Reinberg, Rui-ming Xu Presenter affiliation: National Laboratory of Biomacromolecules, Beijing, China. 117
xxii Re-activation of Vault RNA2-1 by DNA methyation inhibitors in human cancer cells Xiangning Qiu, Marianne B. Treppendahl, Qianjin Lu, Peter A. Jones, Kirsten Grønbæk, Gangning Liang Presenter affiliation: USC/Norris Comprehensive Cancer Center, Los Angeles, California; Epigenetic Research Center, Changsha, China. 118
Genome-wide analysis of epigenome in cell reprogramming Tae-Young Roh Presenter affiliation: POSTECH, Pohang, South Korea. 119
Structural nasis of Sgf29 tandem tudor domain recognizing methylated histone H3K4 to regulate the enzymatic activity of SAGA complex responding to carbon stress Jianbin Ruan, Jing Li, Xiaojiao Xue, Minhao Wu, Zhiqiang Zhu, Jianye Zang Presenter affiliation: University of Science and Technology of China, Hefei, China. 120
HDAC inhibitors regulate the expression of Fgf4 in ESCs and during differentiation Guilai Shi, Furong Gao, Ying Jin Presenter affiliation: Institute of Health Sciences, Shanghai, China. 121
Application of next-generation sequencing to cancer epigenomics Huidong Shi Presenter affiliation: Medical College of Georgia, Augusta, Georgia. 122
Recognition of histone H3K4 trimethylation by the PHD finger of PHF2 modulates histone demethylation Hong Wen, Jingzhi Li, Tanjing Song, Xiaobing Shi Presenter affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 123
Global mapping of Arabidopsis heterochromatin Huan Shu, Wilhelm Gruissem, Lars Hennig Presenter affiliation: ETH Zurich, Zürich, Switzerland. 124
Methylation-unrestricted wide-spread dynamic expression of a rat genomic Long Interspersed Nuclear Element (LINE) under in vivo conditions Deepak K. Singh, Pramod C. Rath Presenter affiliation: Jawaharlal Nehru University, New Delhi, India. 125
xxiii The ATAC histone acetyltransferase complex is a novel Jun transcription coactivator that regulates JNK signaling by a negative feed back loop Tamaki Suganuma, Arcady Mushegian, Selene K. Swanson, Laurence Florens, Michael P. Washburn, Jerry L. Workman Presenter affiliation: Stowers Institute for Medical Research, Kansas City, Missouri. 126
KRAB/KAP1-mediated transcriptional tuning is a master regulator of mammalian homeostasis Didier Trono, Isabelle Barde, Francesca Santoni de Sio, Helen Rowe, Simon Quenneville, Andrea Corsinotti Presenter affiliation: Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. 127
Straightforward finding the transcription factor binding sites Tsang Chieh Ling, Huang Hsiao Ting, Liu Fu Guo Presenter affiliation: National Central University, Jhongli City, Taiwan. 128
KDM7 is a dual demethylase for histone H3 lysines 9 and 27 and functions in brain development Yu-ichi Tsukada, Tohru Ishitani, Keiichi I. Nakayama Presenter affiliation: Medical Institute of Bioregulation, Fukuoka, Japan. 129
Negative regulation of a stress-responsive gene Lydia Miller, Chad Foradori, Avin Lalmansingh, Dharmendra Sharma, Elaine Gregg, Robert Handa, Rosalie Uht Presenter affiliation: Health Institutes of Texas, Fort Worth, Texas. 130
The novel histone deacetylase inhibitor 4-Me2N-BAVAH enhances functional differentiation in cultures of primary hepatocytes Mathieu Vinken, Sarah Snykers, Joanna Fraczek, Tom Henkens, Vera Rogiers, Tamara Vanhaecke Presenter affiliation: Vrije Universiteit Brussel, Brussels, Belgium. 131
The MYST histone acetyltransferase HBO1 is required for H3K14 acetylation and the expression of key patterning genes during embryonic development Andrew J. Kueh, Mathew P. Dixon, Tim Thomas, Anne K. Voss Presenter affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. 132
xxiv The C-terminus of histone variant H2A.Z is important for its deposition and function Alice Y. Wang, Michael S. Kobor Presenter affiliation: University of British Columbia, Vancouver, British Columbia, Canada. 133
Set1-dependent Rpd3L recruitment attenuates gene activation by both deacetylating histones and disassociating NuA4 complex Shan-Shan Wang, Bo O. Zhou, Yao-Ji Xuan, Jin-Qiu Zhou Presenter affiliation: Institute of Biochemistry and Cell Biology, Shanghai, China. 134
Germline PIWI functions downstream of piRNA production in transposon repression through an HP1a mediated mechanism Sidney H. Wang, Sarah C. Elgin Presenter affiliation: Washington University, St Louis, Missouri. 135
ZBP1, a H2A.Z specific binding protein Weixiang Wang, Jian Sun, Xiaojun Ding, She Chen, Bing Zhu Presenter affiliation: National Institute of Biological Sciences, Beijing, China. 136
Using ChIP-Seq to profile senescence-induced changes in histone marks Xiaowo Wang, Chicas Agustin, Michael Q. Zhang, Scott Lowe Presenter affiliation: Tsinghua University, Beijing, China. 137
MicroRNA-224 is up-regulated in hepatocellular carcinoma likely through epigenetic mechanisms Yu Wang, Caroline G. Lee Presenter affiliation: National University of Singapore, Singapore. 138
RPB5-Mediating Protein (RMP) is oncogenic for hepatoma cell SMMC-7721 Huicui Yang, Jingting Jiang, Ming Li, Xiaoning Lian, Jingcheng Miao, Wenxiang Wei Presenter affiliation: Suzhou University, Suzhou, China. 139
Genome-wide CHIP-Seq analysis of histone methylation reveals modulators of NF-kB signaling and the histone demethylase JMJD3 as implicated in disease progression in myelodysplastic syndrome (MDS) Yue Wei, Rui Chen, Carlos Bueso-Ramos, Hui Yang, Guillermo Garcia-Manero Presenter affiliation: University of Texas M. D. Anderson Cancer Center, Houston, Texas. 140
xxv Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex Hong Wen, Joseph S. Lipsick Presenter affiliation: University of Texas M.D. Anderson Cancer Center, Houston, Texas. 141
AID interacts with PCNA Katharina L. Willmann, Heather Coker, Don-Marc Franchini, Maria Simon, Svend K. Petersen-Mahrt Presenter affiliation: Cancer Research UK Clare Hall Laboratories, South Mimms, United Kingdom. 142
The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation Jiemin Wong Presenter affiliation: East China Normal University, Shanghai, China. 143
The Tup1/Cyc8 complex represses transcription by preventing activator function in Saccharomyces cerevisiae. Koon Ho Wong, Kevin Struhl Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 144
To study NRIP –up and –down regulated genes Hsiao-Hui Wu, Show-Li Chen Presenter affiliation: Gradent Insittute of Microbiology, Taipei, Taiwan. 145
Histone methyltransferases KMT1c and KMT1d possess intrinsic chromatin methylation propagating activities Hui Wu, Xiuzhen Chen, Jun Xiong, Yingfeng Li, Hong Li, Xiaojun Ding, Sheng Liu, She Chen, Shaorong Gao, Yoichi Shinkai, Bing Zhu Presenter affiliation: Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; National Institute of Biological Sciences, Beijing, China. 146
The role of N-terminal tails of histone H3 in de novo DNA methylation Guo-Liang Xu, Jia-Lei Hu, Bo O. Zhou, Run-rui Zhang, Kang-Ling Zhang, Jin-Qiu Zhou Presenter affiliation: The State Key Laboratory of Molecular Biology, Shanghai, China. 147
xxvi Object recognition is affected by Jarid1c-induced chromatin remodeling and transcriptional repression of GABAergic neurotransmission Jun Xu, Megan Andreassi, Sam Chang, Gavin Baxter-King, Kelsey Graham, Alex Newbury Presenter affiliation: Tufts University, North Grafton, Massachusetts. 148
Structural study of the C. elegans Arginine symmetric dimethylase PRMT5 Litao Sun, Shlilai Bao, Weimin Gong, Ruiming Xu Presenter affiliation: Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 149
Loss of the H3K4me3 demethylase RBP2 suppresses tumorigenesis Jian Cao, Jiayun Liu, Elizaveta Benevolenskaya, William Kaelin, Qin Yan Presenter affiliation: Yale University School of Medicine, New Haven, Connecticut. 150
Non-canonical function of Cohesin in Drosophila Jingping Yang, Victor Corces Presenter affiliation: Emory University, Atlanta, Georgia. 151
Is it possible wiping out most trans effects during evolution? Shu-Wei Yang, Yun-Yu Lu, Fu-Guo Liu Presenter affiliation: National Central University, Jhongli, Taiwan. 152
Requirement of mammalian TFIIH kinase in efficient general transcription and gene-specific capping Katja Helenius, Ying Yang, Timofey V. Tselykh, Heli K. Pessa, Mikko J. Frilander, Tomi P. Mäkelä Presenter affiliation: University of Helsinki, Helsinki, Finland. 153
Tumor suppressor Menin as a chromatin remodeling Mediator Yong-Jin Yang, Yu-Na Kim, Eun-Jung Cho Presenter affiliation: Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea. 154
Myogenic activation of MyoD with variant histone H3.3 Jae-Hyun Yang, Yunkyoung Song, Eun-Jung Cho Presenter affiliation: Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea. 155
xxvii Genome-wide DNA methylome analysis based on new high throughput sequencing technology Ning Li, Mingzhi Ye, Yingrui Li Presenter affiliation: Beijing Genomics Institute, Shenzhen, China. 156
The roles of Mediator Med23 subunit in transcription control and cell fate determination Jing-wen Yin, Yan Liang, Yan Huang, Wei Wang, Gang Wang Presenter affiliation: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai, China. 157
Suppression of cell cycle progression by jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2 Yu-Chang Huang, Jianzhi Pan, Koji Nakade, Kazunari K. Yokoyama Presenter affiliation: Kaohsiung Medical University, Kaohsiung, Taiwan; RIKEN BioResource Center, Tsukuba, Japan. 158
TMPRSS2-ERG gene fusion, Polycomb, epigenetic changes and cell de-differentiation in prostate cancer Jindan Yu, Jianjun Yu, Cao Qi, Ming Hu, Zhaohui S. Qin, Arul M. Chinnaiyan Presenter affiliation: Northwestern Univeresity, Chicago, Illinois. 159
Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo Wen Yuan, Jingwei Xie, Chengzu Long, Hediye Erdjument-Bromage, Xiaojun Ding, Yong Zheng, Paul Tempst, She Chen, Bing Zhu, Danny Reinberg Presenter affiliation: National Institute of Biological Sciences, Beijing, China; State Key Laboratory of Plant Physiology and Biochemistry, Beijing, China. 160
Epigenetic regulation of circadian gene expression by chemopreventive methylselenocysteine in vivo—Effects on the circadian expression of genes essential to normal mammary cell growth and differentiation Helmut Zarbl, Ming Z. Fang Presenter affiliation: Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey. 161
xxviii Intrinsically disordered protein interactions in chromatin structure Wei Zhang, Marek Tyl, Sara Lejon, Andal S. Murthy, Stephen H. McLaughlin, Nikki Royle, Natalia V. Murzina, Ernest D. Laue Presenter affiliation: University of Cambridge, Cambridge, United Kingdom. 162
A novel hSNF5 interacting protein activates rDNA transcription Niu Zhai, Zhong-liang Zhao, Ye Zhang, Yu-fei Shen Presenter affiliation: Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 163
A PRMT5-dependent repressor complex silences human fetal globin gene expression Quan Zhao, Gerhard Rank, Loretta Cerruti, Stephen M. Jane Presenter affiliation: Nanjing University, Nanjing, China. 164
Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species Dan Xie, Chieh-Chun Chen, Leon Ptaszek, Shu Xiao, Xiaoyi Cao, Harris Lewin, Chad Cowan, Sheng Zhong Presenter affiliation: University of Illinois at Urbana-Champaign, Urbana, Illinois. 165
SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation Bo O. Zhou, Shanshan Wang, Jin-Qiu Zhou Presenter affiliation: Chinese Academy of Sciences, Shanghai, China. 166
Histone H4 lysine 12 acetylation regulates telomere dynamics in Saccharomyces cerevisiae Bo O. Zhou, Shan-Shan Wang, Xiao-Hong Fu, Wei Dang, Yang Zhang, Jin-Qiu Zhou Presenter affiliation: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai, China. 167
In vivo study of HP1α function using lentivirus-mediated shRNA transgenesis Quan Zhu, Gerald Pao, Nina Tonnu, Eugene Ke, Nien Hoong, Oded Singer, Inder M. Verma Presenter affiliation: The Salk Institute for Biological Studies, La Jolla, California. 168
xxix The Mediator component Med5 influences telomeric silencing and cellular lifespan Xuefeng Zhu, Beidong Liu, Jonas O. Carlsten, Thomas Nyström, Lawrence C. Myers, Claes M. Gustafsson Presenter affiliation: University of Gothenburg, Göteborg, Sweden. 169
Cm5CWGG specific BstNI mutant Shengxi Guan, Aine Blanchard, Zhenyu Zhu Presenter affiliation: New England Biolabs, Inc., Ipswich, Massachusetts. 170
The status of rhadinoviral epigenomes in latently infected T cells Katrin Zielke, Barbara Alberter, Florian Full, Armin Ensser Presenter affiliation: University Erlangen-Nuremberg, Erlangen, Germany. 171
WEDNESDAY, May 19—4:00 PM
Jinji Lake Tour
WEDNESDAY, May 19—7:30 PM
SESSION 7 CHROMATIN DOMAINS AND STRUCTURES
Chairperson: R. Martienssen, Cold Spring Harbor Laboratory, New York, USA
Cell-type specific nuclear organization in C. elegans development and its perturbation by lamin mutation Susan M. Gasser, Benjamin D. Towbin, Brietta L. Pike, Anna Mattout, Peter Meister [25’] Presenter affiliation: Friedrich Miescher Institute, Basel, Switzerland. 172
EM studies of eukaryotic transcription complexes—Structural insights into regulation of transcription initiation Gang Cai, Tsuyoshi Imasaki, Ju Huck Lee, Yuichiro Takagi, Arthur Günzl, Francisco J. Asturias [10’] Presenter affiliation: The Scripps Research Institute, La Jolla, California. 173
xxx Structure of the WDR5-RbBP5-Ash2L complex—A flexible platform for MLL1 H3K4 methyltransferase activity Yong Chen, Fang Cao, Ke Wan, Yali Dou, Ming Lei [10’] Presenter affiliation: Howard Hughes Medical Institute and University of Michigan, Ann Arbor, Michigan. 174
Nucleosome thermodynamics, histone modifications, and histone chaperone function Andrew J. Andrews, Xu Chen, Alexander Zevin, Katie Benson, Laurie A. Stargell, Karolin Luger [25’] Presenter affiliation: HHMI/Colorado State University, Fort Collins, Colorado. 175
Adding a lysine or methyllysine mimic in the design of potent inhibitors of histone lysine methyltransferases and demethylases Xiaodong Cheng, Yanqi Chang, Anup K. Upadhyay, John R. Horton, Xing Zhang [25’] Presenter affiliation: Emory University School of Medicine, Atlanta, Georgia. 176
Structural basis for recognition of symmetrically dimethylated Arginine Haiping Liu, Ju-Yu Wang, Ying Huang, Zhizhong Li, Weimin Gong, Ruth Lehmann, Rui-Ming Xu [25’] Presenter affiliation: Institute of Biophysics, Beijing, China. 177
THURSDAY, May 20—9:00 AM
SESSION 8 INTERESTING STUFF
Chairperson: S. Berger, University of Pennsylvania, Philadelphia, USA
KEYNOTE SPEAKER
Richard Young [35’] Whitehead Institute and Massachusetts Institute of Technology Cambridge, Massachusetts
“Connecting transcriptional control to chromosome structure and human disease” 178
xxxi β-arrestin-mediated epigenetic regulation of gene transcription Gang Pei [25’] Presenter affiliation: Institute of Biochemistry and Cell Biology, Shanghai, China; School of Life Science and Technology, Shanghai, China. 179
Widespread transcription at thousands of enhancers during activity-dependent gene expression in neurons Tae-Kyung Kim, Martin Hemberg, Jesse M. Gray, Daniel M. Bear, Jing Wu, Allen M. Costa, David A. Harmin, Kellie Barbara-Haley, Paul Worley, Gabriel Kreiman, Michael E. Greenberg [10’] Presenter affiliation: UT Southwestern Medical Center, Dallas, Texas; Harvard Medical School, Boston, Massachusetts. 180
Differential partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly Mo Xu, Chengzu Long, Xiuzhen Chen, Chang Huang, She Chen, Bing Zhu [10’] Presenter affiliation: National Institute of Biological Sciences, Beijing, Beijing, China. 181
Long non-coding RNAs with enhancer-like functions in human Ulf Andersson Orom, Ramin Shiekhattar [25’] Presenter affiliation: The Wistar Institute, Philadelphia, Pennsylvania. 182
FACT maintains nucleosome stability and couples nucleosome assembly to DNA replication Qing Li, Hui Zhou, Tim Formosa, Zhiguo Zhang [10’] Presenter affiliation: Mayo Clinic, Rochester, Minnesota. 183
Mediator complex mediates the coupling of transcription and alternative splicing Yan Huang, Xiao Yao, Jingwen Yin, Jingyi Hui, Gang Wang [10’] Presenter affiliation: Institute of Biochemistry and Cell Biology, Shanghai, China. 184
Chd1 disassembles nucleosomes on native templates in a promoter-specific and activator-dependent fashion Andreas H. Ehrensberger, Roger D. Kornberg [10’] Presenter affiliation: Stanford University, Stanford, California. 185
Histone 3 variants dynamics during sexual reproduction in Arabidopsis Frederic Berger, Mathieu Ingouff, Sze Jet Aw [10’] Presenter affiliation: Temasek LifeScience Laboratory, Singapore, Singapore. 186
xxxii THURSDAY, May 20—2:00 PM
SESSION 9 EPIGENETICS, STEM CELLS AND REPROGRAMMING
Chairperson: E. Selker, University of Oregon, Eugene, USA
Resetting the epigenome during development and in the germ line Azim M. Surani [25’] Presenter affiliation: University of Cambridge, Cambridge, United Kingdom. 187
Features of the germline epigenome in zebrafish and humans Brad R. Cairns, Shan-Fu Wu, Sue Hammoud, Douglas Carrell, Haiying Zhang [25’] Presenter affiliation: University of Utah, Salt Lake City, Utah. 188
Nuclear transfer as a new tool for study of reproduction and genome preservation Teruhiko Wakayama [25’] Presenter affiliation: RKEN Center for Developmental Biology, Kobe, Japan. 189
Regulation of PRC2 and cell pluripotency by JARID2/MTF2/esPRC2p48 in ES cells Zhuo Zhang, Amanda Jones, Chiao-Wang Sun, Heui-Yun Joo, Dian Dai, Hediye Erdjument-Bromage, Paul Tempst, Tim Townes, Hengbin Wang [10’] Presenter affiliation: University of Alabama at Birmingham, Birmingham, Alabama. 190
A specialized chromatin remodeling complex coordinates LIF signaling with the transcriptional circuitry of pluripotency Gerald R. Crabtree [25’] Presenter affiliation: Stanford University/HHMI, Stanford, California. 191
Diverse functional, epigenetic states of chromatin in multipotent progenitor cells Ken Zaret, Cheng-Ran Xu [25’] Presenter affiliation: University of Pennsylvania, Philadelphia, Pennsylvania. 192
xxxiii A requirement for protein arginine methyltransferase 1 for the development of vertebrate adult intestinal stem cells Yun-Bo Shi [10’] Presenter affiliation: NICHD, National Institutes of Health, Bethesda, Maryland. 193
Chromatin responses to DNA damage Yunhe Bao, Xuetong Shen [10’] Presenter affiliation: MD Anderson Cancer Center, Smithville, Texas. 194
THURSDAY, May 20—6:00 PM
BANQUET
FRIDAY, May 21—9:00 AM
SESSION 10 EPIGENETICS AND DISEASE
Chairperson: K. Luger, Colorado State University, Fort Collins, USA
KEYNOTE SPEAKER
Michael G. Rosenfeld [35’] Howard Hughes Medical Institute, University of California-San Diego La Jolla, California
“Transcription, growth and translocation—A synchrony of movement, DNA repeats, and ncRNAs” 195
The cancer epigenome and epigenetic therapy Peter A. Jones [25’] Presenter affiliation: University of Southern California Norris Cancer Center, Los Angeles, California. 196
xxxiv Chromatin modifying enzymes—Their function and role in cancer Tony Kouzarides [25’] Presenter affiliation: University of Cambridge, Cambridge, United Kingdom. 197
An epigenetic switch that links inflammation and Polycomb complexes to cancer Kevin Struhl [25’] Presenter affiliation: Harvard Medical School, Boston, Massachusetts. 198
Epigenetic regulation of Reptin and Pontin Chromatin-remodeling complexes Sung Hee Baek [25’] Presenter affiliation: Seoul National University, Seoul, South Korea. 199
Activation of HDAC3 by HIF-1alpha regulates epithelial- mesenchymal transition Kou-Juey Wu, Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang, Shu-Chun Teng [10’] Presenter affiliation: National Yang-Ming University, Taipei, Taiwan. 200
Concluding Remarks
Rui-Ming Xu Institute of Biophysics Chinese Academy of Sciences
xxxv