Embracing Evolution Meeting New Challenges for Science and Society

WISTARannual ANNUAL r REPORTeport 2009 2009 1 “survival of the fittest” is a curious As a research institute, we have, in recent way to describe evolution, because it hardly years, augmented our traditional programmatic explains what it takes to survive and what it structure with new centers that foster the means to be fit. Fitness is not always measured “team science” approach, which maximizes in size or dominance. The saber-tooth tiger our strengths while allowing us to remain was an extraordinarily fit beast, for example, nimble enough to adapt to an ever-changing but I have yet to see one padding down research landscape. This flexibility enables us Spruce Street here in Philadelphia. to pursue new funding opportunities and What I do see on Spruce is the edifice of brings our researchers together organically The Wistar Institute, the main entrance of in order to tackle emerging scientific questions. which has scarcely changed since our founder, We currently have six centers, including Isaac Wistar, first stepped inside in the late our NCI-designated Cancer Center, with 1800s. Yet, if he walked these hallways today a seventh, the Melanoma Research Center, he would see profound differences: a 21st getting ready to open even as I write this century biomedical research institute carrying letter in the spring of 2010. out his vision in bold new ways that he As individual investigators, Wistar scientists could hardly have predicted. not only adapt to new science, they change We chose evolution as the central theme for the very research environment through the 2009 Annual Report only in part because their discoveries. Our researchers were at 2009 marked the bicentennial of Charles the forefront of translational science, moving Darwin’s birth and the sesquicentennial of research advances into the clinic long the publication of his groundbreaking treatise before the term “translational science” was “Nothing in biology makes sense except in the light of evolution.” “On the Origin of Species,” which would coined. And, as you will read in these pages, forever change our way of thinking about tumor microenvironment and RNA editing — Theodosius Dobzhansky, Genetics and the Origin of Species, 1937 science and medicine. are two emerging fields that we continue to play a fundamental role in establishing. The Wistar Institute embodies an essential Already, we have begun to see new aspect of evolutionary theory: adaptation, teams at Wistar coalesce naturally to the ability to respond to a changing environ- study these important areas. ment by applying our inherent strengths to new scientific challenges. In that sense, Wistar At Wistar, we are evolution in action. The is indeed a “fit” organization. We do more future holds ever greater promise for bringing than merely survive, however, we flourish. biomedical discoveries from our laboratories to benefit humankind. I invite you to join us As an administration, we have adapted as we continue to adapt to meet the challenges to a challenging fiscal environment through and opportunities that lie ahead. a combination of foresight, strategic planning, and hard work.

Russel E. Kaufman, M.D. President and CEO

Survival of the fittest.

2 WISTAR ANNUAL REPORT 2009 1 Embracing Evolution contents 4 Mission Advances (R)Evolutionary Wistar 4 Today, The Wistar Institute finds new Wistar promotes both technology ways to fulfill Isaac Wistar’s dream transfer and translational medicine, Key Moments 6 of a center for “new and original and has done so since before the terms Making the Most research” in the biological and medical were widely used. From vaccines to of an Unfriendly Environment 8 sciences. We can draw a straight monoclonal antibodies to the current line of progress from the founding exploration of targeted therapeutics, RNA, The Amazing 10 of the Institute over a century ago Wistar demonstrates its motto: today’s to the world-class biomedical research science creates tomorrow’s cures. Year in Review 12 organization it is today. Education Previewing the Science of Tomorrow 18 Leadership in Science Wistar trains outstanding scientists, 8 Message from the Chair 21 Wistar embraces new ideas and and has done so for generations. From technologies to expand the boundaries high school students to postdoctoral Cumulative Giving 22 of science. Investigators meet the researchers, the guidance and nurturing ever-changing nature of biomedical of young investigators remains a vital Annual Giving 24 research head-on and “follow the part of the Wistar mission. science,” rising to the challenge Spotlight 29 of discovery. Outreach In Honor of… 30 Wistar shares its discoveries with the community, through education In Memory of… 32 and public discourse that extend the relevance of the Institute’s new and Staff and Administration 34 exciting research into our daily lives. 10 Board of Trustees 36

Leadership Council 37

2 WISTAR ANNUAL REPORT 2009 3 Indeed, throughout its history, The Wistar Now, The Wistar Institute is a leader in cancer Cancer, Institute has remained at the forefront of research and immunology, as well as the (R)Evolutionary biomedical research, expanding the frontiers genetics underpinning all of modern biology Evolution in of basic science knowledge as well as providing and medicine. And Wistar continues to Real-time the tools, like the Wistar rat, to make define the frontiers of science. Where once further expansion possible. we worked to obliterate German measles, Evolution is a defining we now are making great strides against HIV factor in cancer, one that As the 20th century progressed, the face of contributes to the success and influenza. Where once we helped shape research at Wistar slowly changed as the Institute of tumors — and may the field of cancer genetics, we now push the — as well as the fields its researchers studied hold clues to their defeat. boundaries of epigenetics, an emerging field — matured and evolved. The passing of Populations of cancer that dictates how genes can be altered without cells adapt through natural Greenman and Donaldson led to the appoint- changing the genes themselves, offering selection in ways remark- Wistar ment of Edmond J. Farris, M.D., as director. entirely new paradigms for treating disease. ably similar to populations Farris would become a renowned expert in of animals. In 1905, a meeting took place at The Wistar Institute that would forever change the course the field of human fertility, and his book on How the “One of The Wistar Institute’s greatest strengths “I t is not just a metaphor Nation’s First of basic science research, both at Wistar and in the world at large. Milton Greenman, M.D., human anatomy for art students remains an has been the ability to attract top minds who to say tumor cell popula- the young director of a still-young Institute, sought counsel from ten of the nation’s top art school staple 60 years after it was first are willing to follow the science, to go where tions are evolving,” said published. By mid-century, the Institute was a the evidence leads them,” said Russel E. Kaufman, Carlo C. Maley, Ph.D., Independent anatomists on the direction of basic science research to be explored by Wistar scientists. world-recognized center of American biology. M.D., Wistar president, C.E.O. and director an assistant professor Research of the Wistar Cancer Center. “And the traditional in Wistar’s Molecular and the consensus opinion of the conference In addition to housing the anatomy museum, In 1957, the appointment of Hilary Koprowski, strength of Wistar’s administration has been Cellular Oncogenesis Institution attendees led to the first three basic science The Wistar Institute building, which opened M.D., as director would further move Wistar Program. programs — neurology, comparative anatomy, in 1894, would provide researchers with to support them in their efforts.” Embraces the into the fields of immunology and virology. “When you apply chemo- and embryology — at Wistar, the rippling laboratories and free them to conduct “any This new research emphasis would bear fruit While nobody can predict with certainty what therapy to a population of Evolutionary effects from which are still being felt at other work for the research in, or increase of in the form of vaccines against rubella (German lies in store for scientific progress in the 21st tumor cells, you’re quite the Institute to this day. The early science original scientific knowledge,” as written in measles), rabies, and later, rotavirus — part of century, Wistar has demonstrated a keen likely to have a resistant Nature of of neurology and embryology, in particular, the Institute’s Second Deed of Trust in 1898. an era in vaccinology that would save countless evolutionary ability to embrace emerging mutant somewhere in that provided the very basis of later exploration population of billions or Science The meeting would ensure that Isaac Wistar’s lives and dramatically increase the average science and the resulting tools for understanding into the molecular biology of cancer. even trillions of cells.” vision would persist, and it served as a seminal human life span. that these discoveries offer. New efforts in computational biology, epigenetics, and The Maley laboratory is Also present that day was Isaac J. Wistar, moment in the evolution of Wistar. Only a Perhaps the greatest evolutionary leap in Wistar’s RNA-based gene regulation — combined using the mathematical who took an active role on the Wistar board year after the conference of anatomists, Greenman development occured in 1972, when the Institute tools of population biology with traditional strengths in vaccines, cancer, of managers. It was Isaac who founded the along with Wistar neurologist Henry H. was named a National Cancer Institute Cancer and genetic measurements and immunology — are clear signs that Institute in 1892 to preserve the legacy of his Donaldson, Ph.D., and embryologist Helen Center. The designation allowed Wistar to from tumor samples in The Wistar Institute continues to set the great-uncle, Caspar Wistar, famed anatomist, Dean King, Ph.D., would introduce the albino expand its scientific capabilities as well as its order to understand the physician and public intellectual. After years of Wistar rat, the first standardized laboratory pace in the pursuit of knowledge. effects of current therapies physical footprint, with the construction of and to develop better neglect, Caspar Wistar’s collection of anatomical animal. The animal would be a boon to a cancer research wing in 1975. methods to treat and teaching aids, created for the use of medical neurology research and basic science in general prevent cancer. In particular, In the 1980s, ongoing cancer and immunology students and scientists, were in need of repair. — estimates suggest that nearly half of all Maley is trying to delay The Wistar Institute would restore and, over rats used in research today descended from research at Wistar would result in critical the onset of cancer by the years, expand the collection of these models the initial strain of Wistar rat. (The National advances in the production of monoclonal slowing the pace of evolution and scientific artifacts. The archives, which Library of Medicine “PubMed” database antibodies — mass-produced, human-engi- in cells. One approach, are actively maintained today, remain part cites over 10,000 articles in 2009 alone neered antibodies. As human genetics advanced for example, looks at whether non-steroidal of the Institute’s enduring legacy. that reference Wistar rats.) to the point where scientists could link indi- vidual proteins to specific diseases, monoclonal anti-inflammatory drugs, like aspirin, prevent cancer antibody technology helped usher in the modern by reducing the rate era of targeted therapeutics and personalized of genetic mutations. medicine. Drugs like Herceptin (breast cancer), Cimzia (Crohn’s disease), and Avastin (colorectal cancer) all owe their origins to basic monoclonal antibody research. Above: At only 27 years of age, Dr. Milton Greenman (l) became Isaac Wistar’s choice to lead the Institute’s scientific enterprise, succeeding Dr. Horace Jayne (r).

4 5 key moments…

6 WISTAR ANNUAL REPORT 2009 7 Detail from the facade Electron microscope of The Wistar Institute. image of rotavirus. Evolution of The Wistar Institute

Scientific journals published by The Wistar Institute Press.

The 1905 Conference of Anatomists would be recognized as a seminal moment in Wistar’s evolution to a premier biomedical institute. 1924 1957 1972 1980 Wistar installs printing Hilary Koprowski, M.D., Rabies vaccine, Wistar named a presses on site to arrives as fifth director developed at Wistar, National Cancer support an academic of the Institute, and is licensed for Institute-designated publishing enterprise undertakes efforts to human use in Cancer Center, begun in 1905. Wistar modernize and remodel the United States. one of the first Institute Press was laboratory space. research institutes printing and distributing 1892 1894 1905 1906 1910 1961 1962 1969 to achieve this 1979 1989 1993 2002 2006 2008 internationally eight The Wistar Institute The Wistar Institute The conference of Wistar scientists bred the Shinkishi Hatai, Ph.D., Leonard Hayflick, Ph.D., Hayflick and Paul A vaccine developed distinction. Wistar patents the Giorgio Trinchieri, Wistar patents Bcl-2, Wistar’s recently- The rotavirus vaccine Emmanuel Skordalakes, established. building, designed anatomists convened first standardized animal a Japanese zoologist, scientific journals by discovers that a normal S. Moorhead, Ph.D., by Stanley A. Plotkin, method of producing M.D., discovers the first of a family conserved collection of developed at Wistar was Ph.D., becomes the first to house the museum at Wistar declares “the model of any kind, a becomes the first 1924, helping to make cell population can develop the WI-38 M.D., against rubella monoclonal antibodies interleukin-12, of genes that play rare anatomical models approved for use, helping to decode the structure of and foster research, principal object of the significant advancement international scientist Wistar a center of only divide a limited cell line, which (German measles), a against malignant a cell signaling a significant role in from sculptor William to prevent an infection telomerase, the enzyme opens its doors. Institute to be research.” for modern biomedicine. to join Wistar. Hatai American scientific number of times before became instrumental disease whose spread tumors, technology that protein that helps a number of types Rush, made between 1808 that kills over a half that conserves the ends of Nearly half of all rats used would later be known influence. it stops. A fundamental in creating vaccines. reached pandemic led to a number of regulate the body’s of cancer. and 1820, go on display million children each chromosomes (telomeres) in research today are as the father of Japanese concept in modern biology, proportions earlier targeted therapeutics. resistance to for a limited exhibit. year around the world. and is a factor in limiting descendants of the Wistar biology. Today’s Wistar the Hayflick Limit relates in the decade, becomes infections and the number of times a rat. This statue greets all scientists hail from to genetic instability widely available. cancer. normal cell can divide who pass through the 29 countries. in aging cells and the (the Hayflick Limit). Institute’s atrium, a development of cancer. reminder of this early Electron microscope image of triumph and a symbol of rabies virus. In the 1970s Wistar researchers developed the first the debt humankind owes Circa 1998: An interim logo was put into vaccine that can be administered use. The circular ribbon suggests the this humble creature. via baited food to wild animals. Institute’s modern DNA research.

An early logo features a brain, topped by wisteria with the motto “Hominem Sciendo Medicare” (“by knowing man to heal him”).

A Wistar scientist prepares birds, possibly from Dr. Shinkishi Hatai, pictured here with Dr. Stanley Plotkin (left) administers an early human rabies an 1895 expedition to Borneo, for display wife and child, became the first of many vaccine to Dr. Hilary Koprowski (center) while Dr. Tadeusz in the museum. international scientists at Wistar. Wiktor pretends to restrain him. (1971) recent advances at wistar suggest Researchers in Wistar’s Molecular and Cellular that the tumor microenvironment represents Oncogenesis Program, Joseph Kissil, Ph.D., Making the Most an untapped potential for creating new assistant professor, and Ellen Puré, Ph.D., cancer therapies. professor, approach the tumor microenvironment from a different perspective. They study the In the laboratory of Meenhard Herlyn, role of tumor-associated stromal cells — the D.V.M., D.Sc., professor and leader of Wistar’s cells of the surrounding connective tissue — Molecular and Cellular Oncogenesis Program, of an Unfriendly and inflammation, a crucial part of certain for example, the tumor microenvironment chronic diseases as well as a major contributing has been transformed into a valuable tool factor to certain cancers. for studying melanoma and the cancer stem Environment cells thought to drive the disease. According to Puré, the inflammatory response requires a careful balance. Their studies show The Herlyn group has created its own model Wistar Researchers Hunt for Weakness how the connective tissue can influence tumor microenvironment, a three-dimensional culture growth directly or through the inflammation in the Tumor Microenvironment of growing cells. This synthetic skin consists response of the immune system. In healthy of several types of human skin cells grown tissue, inflammation can help destroy pathogens, together on a framework of collagen, the proteins such as viruses and bacteria. However, research that make up the main structural component has demonstrated that chronic inflammation of connective tissue. According to Herlyn, is more likely to lead to cancer, although this model behaves more like real human the reasons are still not clearly known. “The skin than either animal models or traditional inflammatory response can work like a rheostat,” The truth about tumors is that they are not, as often imagined, lone two-dimensional (i.e., flat) cell cultures. said Puré, “We see that immune cells and other “Cells grown in tissue-like models display malignancies or bundles of cancerous cells gone rogue. Tumors stromal cells, such as fibroblasts, are constantly major changes in gene expression similar are, in fact, the result of a rich network of cancerous and otherwise adjusting the amount of inflammation, tuning to those in human patients making them the rheostat to just the right setting to prevent healthy cells that evolve together to form a tumor microenvironment, superbly suited for studies on cell-cell signaling inflammation from going out of balance.” an ecosystem that nurtures disease. and drug resistance,” Herlyn said. In November, Kissil and Puré published a Herlyn’s 3D model also makes an ideal system study in the Journal of Clinical Investigation TOP: Ellen Puré, Ph.D. for trying to understand the role of stem cells BOTTOM: Team science in the Herlyn showing how the tumor-promoting fibroblast in melanoma. Recently, the Herlyn laboratory (second from left) laboratory. activation protein (FAP) sustains the tumor Opposite: Molecular signaling used synthetic skin to study how stem cells in melanoma cells. microenvironment. They found that disrupting (derived from human skin) can be changed the function of FAP can significantly reduce into melanocytes, the pigment-containing cells tumors in mice with lung and colon cancer whose tendency to become malignant gives by blocking some of the important biological melanoma its name. These stem cells represent processes that support tumor growth. “It’s a sort of reservoir for melanocytes in the skin, like taking away the soil from a seed that and the ability of stem cells to renew themselves wants to grow,” said Puré. may help tumors to survive treatment. Targeting cancer stem cells in combination with other Targeting the entire tumor microenvironment is treatments could be a way to prevent mela- also a new way of thinking for the field of cancer noma from recurring, Herlyn says. medicine, a break from its traditional goal of minimizing damage to seemingly healthy cells. While counterintuitive, an “environmental” approach could greatly improve the effectiveness of standard anti-cancer treatments.

“It’s like taking away the soil from a seed that wants to grow.”— Ellen Puré, Ph.D.

8 WISTAR ANNUAL REPORT 2009 9 RNA Harnessing the Emerging Science The Amazing of RNA-guided Genetic Research

as biology students are taught, a “central detritus. According to Kazuko Nishikura, dogma” of molecular biology is that life is made Ph.D., professor in Wistar’s Gene Expression possible by turning genetic information into and Regulation Program, much of this vast proteins. The DNA sequences that comprise terrain of supposed junk is actually a play- genes are transcribed into messenger RNA, ground for non-coding RNA (ncRNA) — which is then translated into a protein. The RNA transcripts of DNA that are not trans- general goal of “reading” DNA, therefore, is lated into protein, yet still remain biologically to create proteins, those essential enzymes and active. Recent discoveries of microRNAs structures present in every process and pathway (tiny RNA molecules processed from ncRNAs) that occurs in every cell in the body. RNA, and their involvement in gene regulation, you might infer, is merely an intermediary. through a mechanism called RNA interference, present a good example, Nishikura says. But we are beginning to see that this picture is far from complete. The scientific understanding Much as mutations in proteins can lead to (L to R) Kazuko Nishikura, Ph.D.; Ramana Davuluri, Ph.D.; What is RNA? Qihong Huang, M.D., Ph.D.; Ramin Shiekhattar, Ph.D. of RNA’s role in how the cell manipulates genes disease, mutations that affect ncRNA have RNA stands for ribonucleic is evolving in a way that will have a dramatic also been implicated in a number of diseases, acid (RNA). Like deoxyribo- impact on how we treat diseases. Wistar scientists from cancer to autism to Alzheimer’s disease, nucleic acid (DNA), RNA are at the vanguard of this emerging field. Nishikura says. For Wistar scientists, unraveling is comprised of a string RNA, the Enhancer study the properties of RNA in human cells this new layer of complexity to the human of nucleotide groups, which “The basic structure of RNA allows it to interact Research conducted in the laboratories of the Shiekhattar and Nishikura laboratories have genome could uncover clues to the origins serve as the individual intimately with specific sequences of DNA,” Shiekhattar and Qihong Huang, M.D., Ph.D., combined their biochemistry expertise with the — and possible treatment — of many diseases. letters of the gene. Unlike said Ramin Shiekhattar, Ph.D., professor in assistant professor in Wistar’s Molecular and genetics know-how of the Huang laboratory. the double-strand of DNA, Wistar’s Gene Expression and Regulation Nishikura’s laboratory was the first to clone Cellular Oncogenesis Program, has revealed Their efforts are further united through RNA is usually formed of a Program. “The concept that RNA can also alter a protein called ADAR1 that edits messenger a new mechanism for explaining how genes are collaboration with Ramana Davaluri, Ph.D., single strand of nucleotides. or direct how genes are expressed adds a RNA transcripts, creating variants of proteins switched on or off. They have discovered that associate professor in the Molecular and Cellular However, the presence and importance of double- “enhancers” — the parts of DNA that bind Oncogenesis Program, who uses the power of complicating layer to the field of genetics, that, in essence, add many more “new” proteins stranded RNAs are to be sure, but it also opens up new possibilities to the genome. Most significantly, RNA editing so-called proteins that regulate certain genes computational biology to analyze the complex increasingly recognized. for researchers to better understand and frequently occurs to non-coding RNAs derived — also encode active RNA. These enhancer- sets of information the team generates. For instance, RNA interfer- treat genetic diseases, such as cancer.” from “junk” DNA including microRNAs. like RNA (elRNA) molecules constitute a ence and RNA editing Together, their findings will change our “We used to believe there were only a limited new way of thinking in biology, one that offers take place on double- RNA, the Editor understanding of RNA-influenced gene number of RNA editing sites, but now we the opportunity to harmonize some poorly stranded RNAs. RNA is Viewing gene regulation with RNA in mind regulation, and how errors in this system realize there may be as many as 20,000 sites understood aspects of gene regulation and inherently less stable than may also help to explain what is perhaps contribute to human diseases, including cancer. DNA, but seemingly much involving perhaps 3,000 genes of non-coding possibly provide new ways to manipulate genes the biggest mystery to emerge from the Human Their efforts will likely yield new scientific more versatile, sometimes regions,” Nishikura said. “Although the that contribute to disease, says Shiekhattar. Genome Project: how few genes there really tools, which could allow researchers to study with enzyme-like activity. biological significance of editing ncRNAs are. As the first draft of the genome was RNA, the Emerging Wistar Team gene regulation, but more importantly, Evolutionary chemists remains to be established, it is anticipated have posited the “RNA completed, previous estimates of more than In the spirit of team science, Wistar researchers could yield an entirely new class of targets that RNA editing alters the expression and World” scenario, in which 100,000 human genes dropped to a “mere” have already begun to work together to for advanced drugs capable of treating disease functions of ncRNAs such as microRNAs RNA, and the RNA/protein 25,000 or so with the remainder of the understand this new, complicated world of by altering the RNA landscape. and enhancer-like RNAs.” connection evolved genome labeled as “junk” DNA, evolutionary RNA-guided genetics. To comprehensively before DNA.

10 11 year in review

Wistar Scientists ID Gene Interactions between Proteins Ramin Shiekhattar Named First that Prevents Breast Cancer and Telomeres that are Herbert Kean, M.D., Family Professor from Mobilizing Crucial for Chromosome Health 2009 marked the return to Wistar of Ramin “ I have been aware of Wistar’s reputation as one Gatekeeper Gene Keeps TERRA Could Be Key to Slowing Shiekhattar, Ph.D., a leading expert in the of the finest research labs in the world,” said Tumors in Place Cellular Aging and Impairing biochemical mechanisms of gene expression, Kean. “When I had the opportunity to participate Cancer Cells with his appointment to the Herbert Kean, in a significant way,I felt honored to fund and Most patients who die of breast cancer do so as M.D., Family Professorship. Shiekhattar rejoins establish this professorship.” a result of metastasis, the complex, multi-step It is one thing to suspect telomeres — lengths of Wistar’s Gene Expression and Regulation Among his many achievements at Wistar in the process by which cancer spreads and proliferates DNA that serve to protect the tips of chromo- Program faculty full-time after two years in study of cancer genetics and epigenetic modifica- at sites around the body. For the first time, Wistar somes — have a role in diseases related to aging, a prestigious Catalan Institution for Research tions to DNA, Shiekhattar and his team discovered scientists have described the function of KLF17, including cancer, but it is quite another to make and Advanced Studies (ICREA) Professorship the machinery by which small bits of RNA known a gene now thought to have an important role use of this information. Now, however, a team of at the Center for Genomic Regulation in as microRNAs (see “RNA article” page 10) are in containing the spread of tumor cells. Their Wistar researchers led by Paul M. Lieberman, Barcelona, Spain. processed and the mechanism microRNAs use findings first appeared in the October on-line Ph.D., has shown that a large strip of RNA, called Shiekhattar first joined The WistarI nstitute in to block the cellular machinery responsible for issue of Nature Cell Biology. the telomere-repeat-encoding RNA, or TERRA, 1997 as an assistant professor, and was promoted translating messenger RNA into proteins. These plays a central role in sustaining telomeres. “ Identifying the gene that suppresses the spread to associate professor in 2001 and to professor in gene-silencing microRNAs have been implicated of tumor cells and the mechanisms by which this According to the researchers, TERRA facilitates 2006. He maintained his laboratory at Wistar and in many cancers, and defining this mechanism suppression occurs can lead to the discovery of the formation of DNA at telomeres — a process part-time faculty status while an ICREA professor. gave researchers a powerful new tool for medical new markers of metastasis and potential targets that can protect aging cells and destabilize tumor research and the creation of new therapies. The Herbert Kean, M.D., Family Professorship for cancer prevention and treatment,” said Qihong cells — and so manipulating its expression may be was established in 2002 by Kean, a prominent “A s the Kean Family Professor, I look forward Huang, M.D., Ph.D., assistant professor in Wistar’s useful in treating cancer and other diseases. Philadelphia surgeon, businessman, and to extending my laboratory’s experiments to Molecular and Cellular Oncogenesis Program “T ERRA is a major component in helping protect the philanthropist and his wife, the Hon. Joyce Kean, elucidate the role of genomic-repression in and senior author of the study. genome at a very sensitive place, the telomeres,” now retired after presiding over the Court of oncogenesis,” said Shiekhattar. “Coming back to According to Huang and his colleagues, KLF17 said Lieberman, a professor in Wistar’s Gene Common Pleas of Philadelphia County. The Wistar is a wonderful opportunity for us to renew interacts in a sort of balancing act with another Expression and Regulation Program and senior endowed position honors Kean family members, and expand our collaborations with our Wistar gene, called Id1. When human cells produce author of the study. “By managing TERRA levels including the late Jeannette Kean, Kean’s first colleagues in ongoing studies of gene expression an excess of Id1, KLF17 becomes inhibited, we have the potential to regulate cellular aging wife, who died of breast cancer in 1989. and regulation.” allowing metastasis to occur. In fact, the Wistar and to impair the functioning of cancer cells.” researchers found that when they knocked out the In August, in the journal Molecular Cell, the Wistar KLF17 gene, cells produced more Id1. Conversely, scientists described how they discovered the they could also blunt Id1’s pro-metastatic telomere proteins that interact with TERRA and effects by boosting activation of KLF17. the processes by which they do so. The identity of According to Huang, the Wistar team is now these telomeric proteins and the nature of their researching how to boost KLF17 levels for interactions with chromosomes provide important therapeutic effect, and also determining clues that point to strategies for altering the whether KLF17 holds a similar gatekeeper expression of TERRA as a means to treat cancer role in other forms of cancer. and other diseases of aging, Lieberman says.

Qihong Huang, M.D., Ph.D. Paul M. Lieberman, Ph.D. (L to R) The Hon. Joyce Kean; Ramin Shiekhattar, Ph.D.; Herbert Kean, M.D.

12 WISTAR ANNUAL REPORT 2009 13 Changes in Gene Activity Could Predict Lung Cancer Findings Could Lead to Blood Test for Early Detection year in review You would not normally expect to hear it in the doctor’s office, but the phrase R“ oll up your sleeve, please, I’d like to check your lungs for cancer,” could one day be as common as “stick out your tongue and say ahh.” In December, in the journal Cancer Research, Wistar researchers published findings that could lead to the development of a simple blood Wistar Patents Universal Flu Vaccine Technology test to detect lung cancer in its earliest phases, when it can be most successfully treated. Universal Vaccine Could Make Annual Flu Shot History, They identified how changes in gene expression Give Advanced Protection against Influenza Pandemics — that is, a profile of which genes are active — in circulating immune cells could serve as Every year, the U.S. Centers for Disease Control published in 2003 by now-retired Wistar inventor, markers that indicate early-stage lung tumors and Prevention tries to predict which strain of Walter Gerhard, M.D., and Laszlo Otvos, Ph.D., in people at high risk for developing lung cancer. influenza will be most prevalent in the coming which demonstrated the potential of targeting M2 Such a test would be the first screening tool year, and then vaccine manufacturers scramble in mouse models of influenza infection. to produce an annual vaccine against that strain. for lung cancer, a disease that often goes The patented peptide vaccine is one of two It is an educated gamble, and at stake are tens undetected until it reaches later stages. strategies toward a universal vaccine from the of thousands of lives. “People routinely get blood taken at their doctor’s Wistar Vaccine Center, led by Hildegund C. J.

Louise C. Showe, Ph.D. office, for cholesterol levels, diabetes, and other In May, however, The Wistar Institute took a major Ertl, M.D., professor and head of the center. standard tests, so why not utilize this method step to break the annual flu cycle in the form of The second strategy uses a viral carrier to elicit to screen for other conditions such as the risk U.S. Patent 7,527,798: a novel synthetic vaccine an immune response. Both may one day be of developing lung cancer?” said Louise Showe, technology that could one day eliminate the need used in sequence to give the immune system Ph.D., professor in Wistar’s Molecular and for annual flu shots. an added boost against flu. Cellular Oncogenesis and Immunology programs While the influenza virus is constantly evolving, and director of its genomics facility. making an annual vaccine necessary, the Wistar Showe, along with lead author Michael K. Showe vaccine prototype targets a more stable, less Ph.D., and colleagues examined gene expression mutable region of the virus. It contains an profiles in blood samples from more than 200 engineered peptide — a protein fragment — patients. Their findings confirmed the notion that mimics a protein on the “coat” of the virus, that immune cells, which normally function to called M2, which remains largely constant from fight tumors, showed certain changes in the year to year. The patent is based upon work patients with malignant tumors that distinguished them from those of patients with other lung diseases, such as chronic obstructive pulmonary disease or emphysema. Currently, the Wistar researchers are working to simplify the method for collecting and processing blood samples for analysis, a necessary step before a clinical blood test could be practical.

14 WISTAR ANNUAL REPORT 2009 15 Sources of Funds Research Centers Federal grant funding $34,039,000 51% The Albert R. Taxin Brain Number of Number of Number of Tumor Research Center Foundation and other private funding $5,686,000 8% employees postdoctoral fellows predoctoral trainees The Center for State funding (Commonwealth of Pennsylvania) $2,868,000 4% Chemical Biology and Translational Medicine Corporate-sponsored research $501,000 1% The Center for Systems 438 64 31 and Computational Biology Unrestricted contributions $1,207,000 2% The Robert A. Fox Structural Biology Center Technology transfer $9,190,000 14% The Wistar Institute Cancer Center Total return from invested funds $13,790,000 20% The Wistar Institute Total $67,281,000 100% Vaccine Center Number of Number of Number of countries of origin laboratories visiting scientists represented

Uses of Funds Shared Facilities 31 25 Direct research $36,054,000 64% 29* Animal Facility Bioinformatics Facility Administration and laboratory services $9,668,000 17% Flow Cytometry Facility Genomics Facility Operation and maintenance of plant $6,213,000 11% Histotechnology Facility Hybridoma Facility U.S. Patents Issued Library operation $464,000 1% Microscopy Facility Molecular Screening Facility Compositions and Methods for Wound Methods and Compositions for Monitoring Depreciation of capital assets $3,791,000 7% Mouse Genetics Facility Protein Expression Facility Healing, Ellen Heber-Katz, Ph.D., Cell Migration and Identifying Clinically Total $56,190,000 100% Proteomics Facility U.S. Patent No. 7,473,414 Relevant Cytotoxic T-Lymphocyte Activity, Research Supply Facility Dorothee Herlyn, D.V.M., D.Sc., Method for Distinguishing Between Head U.S. Patent No. 7,544,465 and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma, Louise Method of Diagnosis of Cancer Based on Showe, Ph.D., U.S. Patent No. 7,514,219 Gene Expression Profiles in Cells, Louise Showe, Ph.D., U.S. Patent No. 7,640,114 Composition and Method for Preventing or Treating a Virus Infection, Walter Direct research 64% Gerhard, M.D., U.S. Patent No. 7,527,798

Administration and laboratory services 17%

Operation and maintenance of plant 11%

*Algeria, Brazil, Canada, China, Croatia, Cuba, Ireland, France, Germany, Ghana, Greece, Hungary, India, Italy, Japan, Kenya, Korea, Malaysia, Depreciation of capital assets 7% Peru, Poland, Romania, Russia, Singapore, Sri Lanka, Taiwan, Trinidad, United Kingdom, United States, Vietnam Library operation 1%

16 WISTAR ANNUAL REPORT 2009 17 Previewing the Science of Tomorrow

Blood Tests Can HIV Be Controlled by for Ovarian Cancer Immunotherapy Alone? In the quest to detect early-stage ovarian While anti-retroviral therapy (ART) remains the cancer, David W. Speicher, Ph.D., professor standard for halting the progress of HIV/AIDS in and co-leader of the Molecular and Cellular patients, ART does not enlist an immune response Oncogenesis Program, is exploring the ovarian itself but targets the virus directly. Previously, tumor “secretome” — the sum total of all the laboratory of Luis J. Montaner, D.V.M., D. Phil., proteins secreted by ovarian tumors in either professor in Wistar’s Immunology Program, had a laboratory cell culture or mouse model. shown that all patients dependent on highly active Speicher and his colleagues then screen ART dosing experience a rebound of the virus these secreted proteins to determine which if they take a break from their drug regimen. can serve as effective biomarkers, or indicators, In an ongoing clinical trial in the Philadelphia for ovarian cancer that could be detected region, Montaner and his colleagues are testing through a blood test. whether a substance called interferon, which “ Ovarian cancer is the leading cause of death immune cells normally produce at an early stage Wistar Researchers Advance Innovative AIDS Vaccine from gynecological cancers primarily because of viral infection, could sustain HIV suppression if HIV, the virus that causes AIDS, has proven response. Unfortunately, anyone who has ever the disease is usually diagnosed too late,” ART is interrupted. Interferon is already part of difficult to vaccinate against due to a combination had a common cold or upper respiratory infection Speicher said. “We recently discovered hundreds curative treatments for hepatitis infection. of factors that include the tendency of the virus has likely developed immunity to human adenovi- of proteins specifically shed by human ovarian “ If we could use interferon to maintain suppression to mutate and the manner by which the virus ruses. Therefore, they are not appropriate vectors cancer tumors into the blood, and we are now of HIV while stopping ART, it would document attacks the immune system. for delivering an HIV vaccine. using an efficient testing strategy to rapidly for the first time that our immune system might screen these candidate biomarkers in patients.” Now, an HIV vaccine developed by Hildegund The Ertl lab solved this problem by using chimpan- be capable of controlling HIV if it is given support C. J. Ertl, M.D., professor, leader of Wistar’s zee adenovirus strains as vectors. In preclinical According to Speicher, their initial results indicate through immunotherapy,” Montaner said. Immunology Program and director of the Wistar studies, the vaccine induced a vigorous immune that they should be able to develop new diagnostic Vaccine Center, may circumvent some of these response in monkeys, and the researchers are tests for both early cancer detection and clinical barriers by using a chimpanzee virus as a means hopeful it will do the same in humans, Ertl says. management of the disease after diagnosis. of activating the human immune system. Recently, Ertl received grants totaling more than Previous attempts at creating an AIDS vaccine $15 million from the National Institute of Allergy have used engineered human adenoviruses, and Infectious Diseases to further develop the called vectors, to deliver genetic elements from vaccine for testing in humans. HIV into a patient’s cells to stimulate an immune

18 WISTAR ANNUAL REPORT 2009 19 we all have different reasons for It is also a uniquely Philadelphia organization, being involved in the work that goes on at as its history is deeply intertwined with that The Wistar Institute. Maybe someone dear of both the region and its citizenry. In the to you is a cancer survivor. Perhaps you have years before the federal government supported seen the devastation wrought by infectious biomedical research, The Wistar Institute disease and understand the value of vaccine was entirely supported through philanthropy. research. Or maybe you just want to support Isaac J. Wistar, himself, funded the construction “The scientific advances, vaccines, therapeutics and an excellent team of scientists in order to of the original Wistar building with $100,000 technologies Wistar scientists made possible over the years make a lasting difference in this world. of his own money. I think we can all agree that Wistar has As a member of the board of trustees, I am have alleviated suffering in the world and provided made an enduring impression on science and honored to be part of a long line of civic-minded medicine. The scientific advances, vaccines, men and women, who, for more than a millions of people with hope for a healthy future.” therapeutics and technologies Wistar scientists century, have worked in conjunction with — brian h. dovey, Chair, Board of Trustees made possible over the years have alleviated some of the finest scientific minds in the world. suffering in the world and provided millions To me, this is a source of tremendous pride. of people with hope for a healthy future. While my belief in the value of Wistar is Wistar is a remarkably global organization, built on its scientific track record, my support both in terms of the far-reaching impact for it stems from my confidence in its great of its legacy and also in terms of the breadth accomplishments yet to come. I believe of collaborations and partnerships Wistar that your help in furthering the Institute’s scientists continue to foster. mission is indicative of your confidence in the organization, as well. On behalf of the Wistar board of trustees, I would like to thank you for your ongoing support and invite you to encourage others to join us. Brian H. Dovey Chair, Board of Trustees

20 WISTAR ANNUAL REPORT 2009 21 President’s Council – ($1,000,000.00 + ) Noreen O’Neill Foundation for Melanoma Research Guarantor – ($10,000.00 + ) Mr. and Mrs. H. Lewis Klein Mr. and Mrs. Harold M. Davis Mr. Albert Ominsky, Esquire and Ms. Paula Dresnin Mr. and Mrs. Robert S. Adelson Mrs. Lillian S. Kosloff The Ellison Medical Foundation Robert Leet & Clara Guthrie Patterson Trust Mr. and Mrs. William A. Albert Mrs. David Kritchevsky Mr. and Mrs. Robert A. Fox Gustavus & Louise Pfeiffer Research Foundation Mr. and Mrs. Robert M. Alper Mr. and Mrs. Thomas F. Lafferty Dr. Herbert Kean and The Honorable Joyce Kean Mr. and Mrs. Seymour S. Preston, III Ms. Carol A. Ammon and Dr. Marie Pinizzotto Mr. and Mrs. Harvey Lamm F. M. Kirby Foundation, Inc. Mrs. S. Edward Rhoads Mrs. Jane T. Andress Mr. Mitchell G. Leibovitz G. Harold & Leila Y. Mathers Charitable Foundation Mr. and Mrs. Gerald B. Rorer Mr. Robert Angevine Mr. and Mrs. H. F. Lenfest Pennsylvania Department of Community Mr. and Mrs. Lester Rosenfeld Atlantic Real Estate Group Mr. and Mrs. Howard H. Lewis and Economic Development Mrs. Julia Rousso Elaine and Vincent Bell Foundation Harry A. Lieberman Foundation The Pew Charitable Trusts Mr. and Mrs. Ronald Rubin Morris S. Bender and Florence H. Bender Foundation Lisker Foundation Philadelphia Health Care Trust Ms. Emily Brown Shields Mr. John K. Binswanger The Karen and Herbert Lotman Foundation Fannie E. Rippel Foundation Mr. and Mrs. Edward Sickles Mr. and Mrs. Alan D. Bleznak Lupus Foundation of Southeastern Pennsylvania, Inc. Mr. and Mrs. Sylvan M. Tobin The Hoxie Harrison Smith Foundation Mr. and Mrs. Kenneth M. Bleznak Mr. and Mrs. James J. Lynch W. W. Smith Charitable Trust The Mary L. Smith Charitable Lead Trust Mr. and Mrs. Francis X. Bresnan Mr. and Mrs. John A. Lynott Mr. and Mrs. John W. Sullivan Fred J. Brotherton Charitable Foundation Mr. and Mrs. Larry Magid Isaac Wistar Society – ($500,000.00 + ) Mrs. Doris R. Taxin and Mr. Jack Stievelman Dr. and Mrs. T. Wister Brown Samuel P. Mandell Foundation The Breast Cancer Research Foundation Howard S. Turner, Ph.D. Leonard A. Bruno, M.D. Mr. Nicholas V. Martell The Wistar Institute Leadership Council Mr. Ira Brind Mr. and Mrs. David V. Wachs Mr. and Mrs. Ronald L. Caplan Mrs. Donald McDonald hosted a reception to launch the 2009 Nikon CLAWS Foundation Samuel Waxman Cancer Research Foundation Louis N. Cassett Foundation Dr. Susan Schwartz McDonald and Mr. Graham McDonald Small World photomicrography contest. Cumulative Mr. Arthur Dantchik Ms. Amy A. Fox and Mr. Daniel H. Wheeler Dr. and Mrs. James Cavanaugh Merck & Co. Inc. James Hayden (left), manager of Wistar’s Mr. and Mrs. Joseph Kestenbaum The William Penn Foundation Cephalon Merck Research Laboratories microscopy facility, explains his award- Giving Edward Mallinckrodt, Jr. Foundation Mr. C. Cresson Wistar Mr. and Mrs. Robert E. Chappell Mr. Henry S. Miller, Jr. and Mr. Ken Nimblett winning image to a guest. The Elsa U. Pardee Foundation Ms. Stacy Chern and Mr. Ty Wu Morphotek, Inc. for donors active Patron – ($50,000.00 + ) The Philadelphia Foundation Mr. and Mrs. Winston Churchill MSR Imports American-Italian Cancer Foundation in the last 10 years Mr. and Mrs. Harold G. Schaeffer Mr. and Mrs. Alvin H. Clemens National Analysts, Inc. The Annenberg Foundation Sibley Memorial Hospital The Coca-Cola Foundation Joanna M. Nicolay Melanoma Foundation Helen D. Groome Beatty Trust The V Foundation for Cancer Research Comcast Spectacor Novitas Capital Mr. Peter A. Benoliel and Ms. Willo Carey Connelly Foundation Old Original Bookbinder’s Restaurant BNY Mellon Wealth Management Centennial Society – ($100,000.00 + ) Mr. and Mrs. I. Michael Coslov Mr. and Mrs. Robert Oppenheimer Mrs. June H. Chern Accelerate Brain Cancer Cure Cotswold Foundation Oxford Foundation, Inc. Citizens Bank of Pennsylvania Dr. Miriam & Sheldon G. Adelson Charitable Trust Cozen O’Connor Pepper Hamilton, LLP Mr. and Mrs. Stephen Allen Cozen American Association for Cancer Research CRW Graphics Mr. and Mrs. Roy T. Peraino Delaware Valley Innovation Network American Health Assistance Foundation Mr. David Cutler Mr. and Mrs. Timothy P. Pesce Mrs. Stephanie S. Eglin The Arcadia Foundation Robert C. Daniels, Esquire The Philadelphia Coca-Cola Bottling Co. Federation Foundation of Greater Philadelphia Barra Foundation, Inc. Mr. C. Edwin Davis Philadelphia Phillies Mr. and Mrs. Joseph M. Field Arnold and Mabel Beckman Foundation Mr. and Mrs. Rodney D. Day, III Mrs. Glorita Porreca-Maida Mr. and Mrs. Bruce A. Goodman Mr. and Mrs. Vincent G. Bell, Jr. Dolfinger-McMahon Foundation PRWT Services Mr. and Mrs. Daniel B. Green Mrs. Ian J. Berg The Dovey Family Foundation Quaker Chemical Foundation The Honorable and Mrs. Harris N. Hollin Mr. and Mrs. Robert S. Blank Mr. and Mrs. Stanley Druckenmiller Dr. and Mrs. Frank J. Rauscher, III Mr. and Mrs. Richard M. Horowitz Breast Cancer Alliance, Inc. Electric Factory Concerts Realen Properties Mr. and Mrs. Ira M. Ingerman The Campbell Foundation Mr. and Mrs. Stanley Elkman Dr. and Mrs. Donald Vail Rhoads Mr. John Kinderman Cancer Research and Prevention Foundation Mr. Julius W. Erving Mr. and Mrs. William G. Rhoads Mr. and Mrs. Ronald A. Krancer The Children’s Tumor Foundation Mr. and Mrs. Joseph J. Fenkel Mr. and Mrs. George M. Ross John M. Lloyd Foundation The Concern Foundation for Cancer Research Fidelity Charitable Gift Fund Mr. and Mrs. Marvin J. Rounick Mr. and Mrs. Herbert Lotman The Dana Foundation Fisher Scientific Safeguard Scientifics, Inc. Mr. and Mrs. Alan B. Miller Mr. and Mrs. Brian H. Dovey Mr. and Mrs. Mark Fishman Mr. and Mrs. George U. Sauter Mr. and Mrs. I. Wistar Morris, III The Meyer and Stephanie Eglin Foundation Ms. Sara Jane Fitzpatrick Mr. and Mrs. Ernest Scheller, Jr. Pharmaceutical Research The Emerald Foundation Fleet Bank Mr. and Mrs. Paul J. Schmitt and Manufacturers of America Foundation Charlotte Geyer Foundation The Richard J. Fox Foundation Mr. and Mrs. Milton S. Schneider The PNC Financial Services Group GlaxoSmithKline Mr. and Mrs. Richard J. Fox Mr. Richard A. Scott Mr. and Mrs. David B. Pudlin The Horace W. Goldsmith Foundation Mr. and Mrs. Benjamin Frankel SEI Investments Company RAF Industries Mr. and Mrs. John C. Haas Mr. and Mrs. Stanton H. Friedman Mr. and Mrs. Roy Shapiro Mr. and Mrs. Robert H. Rock Phoebe W. Haas Charitable Trust “B” Friedman-French Foundation Franz W. Sichel Foundation Martha W. Rogers Charitable Trust Irving A. Hansen Memorial Foundation GBH Foundation Sovereign Bank Dr. and Mrs. Karl F. Rugart, Jr. The Hassel Foundation Genentech, Inc. Dr. and Mrs. David W. Speicher Mary A. H. Rumsey Foundation Mrs. Beverly Hattersley Mr. Joel Gershman and Ms. Elaine Levitt Mr. and Mrs. Barry E. Tague sanofi pasteur Mr. and Mrs. Roger S. Hillas Mr. and Mrs. Joseph A. Goldblum Mr. and Mrs. Larry Tanenbaum Mr. James R. Schaeffer Innisfree Foundation of Bryn Mawr Viola N. Goodrich Irrevocable Trust Mr. and Mrs. Edward Tawil The Scholler Foundation Jewish Federation of Greater Philadelphia Mr. and Mrs. Irwin Govberg Mrs. Jean M. Taxin The Charles Spear Charitable Trust Max Kade Foundation Mr. Joel K. Greenberg and Ms. Marcy Gringlas Robert M. Taxin, D.O. Susquehanna Foundation Katie’s Kids for the Cure Dr. Jennifer Gross and Mr. Eli A. Gross Mr. and Mrs. Thomas J. Teesdale Mr. James D. Troyer and Ms. Kathleen Callan Mr. Leroy E. Kean Mrs. Samuel M. V. Hamilton Thomas Jefferson University Hospital Vanguard Charitable Endowment Program Mrs. Patricia Kind Mr. and Mrs. Brian G. Harrison Tiaa-Cref Employee Giving Campaign Wawa Inc. Susan G. Komen Breast Cancer Foundation Louise A. Havens Foundation for Diabetes Research & Treatment Mrs. Owen J. Toland Hilary Koprowski, M.D. Ellen Heber-Katz, Ph.D. and David Sarfatti Mr. and Mrs. Gilbert Tucker Mr. and Mrs. Ronald J. Kozich Drs. Meenhard and Dorothee Herlyn Mr. and Mrs. Kevin M. Tucker Mr. Ira M. Lubert Mr. and Mrs. Harold Honickman Rae S. Uber Trust Mrs. Louis C. Madeira, IV Howson & Howson, Ltd. Universal Health Services, Inc. March of Dimes Foundation IBEW/NECA Mr. and Mrs. Richard A. Vermeil Mr. and Mrs. Dan W. Matthias Invitrogen Mr. and Mrs. Morton B. Wapner The McLean Contributionship Mr. and Mrs. Jerry L. Johnson Mrs. Barbara R. Washburn Mrs. Joan Miller Kaplan Pomerantz Schaeffer Foundation Mr. and Mrs. Bryan S. Weingarten The Warren V. Musser Foundation Mr. and Mrs. Harold Katz Mr. and Mrs. Laurence N. Weiss National Brain Tumor Society Dr. and Mrs. Russel E. Kaufman Mr. and Mrs. Mark Wilf National Medical Technology Testbed Mr. Larry A. Keinath and Ms. Rosemary Spingler Ms. Monica Polowy Winter Mrs. Agnes Eckhardt Nixon Lenore and Howard Klein Foundation Mrs. Joan H. Wister

22 WISTAR ANNUAL REPORT 2009 23 Caspar Wistar Society – ($1,000,000.00 + ) Mr. and Mrs. Bruce A. Goodman Wistar Fellows Society – ($1,000.00 + ) Mr. Leroy E. Kean above Left: Ilene and Francis annual The Ellison Medical Foundation The Hassel Foundation Mr. and Mrs. Robert S. Adelson Mr. and Mrs. Leonard M. Klehr Bresnan attended a “friend-raiser” Philadelphia Health Care Trust Mr. and Mrs. Harold Honickman Mr. and Mrs. Dean Adler Mr. and Mrs. Leonard I. Korman in Palm Beach, Florida, hosted by Giving Mr. and Mrs. Sylvan M. Tobin Thomas Jefferson University Hospital Mr. and Mrs. William A. Albert Dr. and Mrs. James F. Korsh Adele and Harold Schaeffer. 2009 Dr. Herbert Kean and The Honorable Joyce Kean Mr. and Mrs. Robert M. Alper Mr. and Mrs. Thomas F. Lafferty above Right: Author Jon Franklin Issac Wistar Society – ($500,000.00 + ) Mr. and Mrs. Ronald A. Krancer Mrs. Jane T. Andress Mrs. Evelyn Lieberman meets and greets friends of Wistar Mr. and Mrs. Joseph Kestenbaum The Karen and Herbert Lotman Foundation Ballinger Architecture & Engineering Mr. and Mrs. Robert E. Linck at a book signing event for his “A Wolf in the Parlor.” Centennial Society – ($100,000.00 + ) Dr. Susan Schwartz McDonald and Mr. Graham McDonald Mr. Scott Barsky Mr. Ed Lovelidge Mr. and Mrs. I. Wistar Morris, III Mr. and Mrs. Seymour G. Mandell Opposite left: Guests enjoy the The Children’s Tumor Foundation Mr. and Mrs. Max M. Berger Joanna M. Nicolay Melanoma Foundation Mr. and Mrs. Alan B. Miller Nikon Small World photomicrography CLAWS Foundation Mr. David R. Binswanger The PNC Financial Services Group Mrs. Joan Miller exhibit at a reception hosted by Mr. Arthur Dantchik Mr. and Mrs. Kenneth M. Bleznak Mrs. Glorita Porreca-Maida Mr. and Mrs. Edward S. Morris Wistar’s Leadership Council. Mr. and Mrs. Harold M. Davis Mr. and Mrs. Fred E. Braemer Mr. and Mrs. Seymour S. Preston, III Mr. and Mrs. Charles Murray Mr. and Mrs. Robert A. Fox Mr. and Mrs. Douglas S. Briggs Opposite right: Fore! At the 2009 Mr. and Mrs. Robert H. Rock Mr. and Mrs. Howard Needleman Albert R. Taxin Golf Classic (l to r) Innisfree Foundation of Bryn Mawr Mr. and Mrs. Robert E. Chappell Martha W. Rogers Charitable Trust Novartis Vaccines and Diagnostics Dick Vermeil, Russel Kaufman, Mr. and Mrs. Dan W. Matthias Dr. Catherine Chern Mr. and Mrs. Gerald B. Rorer Noreen O’Neill Foundation for Melanoma Research Doris Taxin, Jack Stievelman National Brain Tumor Society Chester County Community Foundation Mr. and Mrs. Milton S. Schneider ParenteBeard, LLC Mr. and Mrs. Harold G. Schaeffer Citizens Bank of Pennsylvania The Scholler Foundation Mr. and Mrs. Stuart Peltz Sibley Memorial Hospital CMS Companies Mr. James D. Troyer and Ms. Kathleen Callan Pepper Hamilton, LLP W. W. Smith Charitable Trust Concord Advisory Group Vanguard Charitable Endowment Program Mr. and Mrs. Timothy P. Pesce The V Foundation for Cancer Research Mr. and Mrs. Harry Cook Ms. Amy A. Fox and Mr. Daniel H. Wheeler Ms. E. K. Pomerantz and Mr. Leslie Miller Samuel Waxman Cancer Research Foundation Mr. and Mrs. Peter E. Corrado Mr. and Mrs. I. Michael Coslov PricewaterhouseCoopers, LLP Insurer – ($5,000.00 + ) Patron – ($50,000.00 + ) Samuel D. Cozen Memorial Fund PRWT Services Mr. Robert Angevine American Association for Cancer Research Mrs. Margaret F. Cristofalo Dr. and Mrs. Frank J. Rauscher, III Baer Corwin Insurance Agency Breast Cancer Alliance, Inc. CRW Graphics Realen Properties Mr. and Mrs. Vincent G. Bell, Jr. Mr. Ira Brind Ms. Barbara DeMare Mr. and Mrs. Stanley Reichlin Mrs. Ian J. Berg Dana Foundation Philip Dormitzer, M.D., Ph.D. Dr. and Mrs. Kenneth Scott Resnik Ms. Stacy Chern and Mr. Ty Wu Delaware Valley Innovation Network Ms. Lee Ducat Dr. and Mrs. Donald Vail Rhoads Comcast Spectacor The Emerald Foundation Mr. and Mrs. Brian Effron Mr. Brett Rhode Mr. and Mrs. Stephen Allen Cozen Phoebe W. Haas Charitable Trust “B” Mr. and Mrs. Barry Feinberg Mr. and Mrs. Adam Rosenfarb Mr. M. Gordon Daniels Mr. and Mrs. John C. Haas Mr. and Mrs. Joseph J. Fenkel Mr. and Mrs. Marvin J. Rounick Mr. and Mrs. Rodney D. Day, III Horace W. Goldsmith Foundation Firstrust Bank RSM McGladrey, Inc. The Esselen Family Fund of the Saint Paul Foundation F. M. Kirby Foundation, Inc. Fishman and Tobin Mr. and Mrs. Seymore Rubin Fastrack Construction, Inc. Mrs. Louis C. Madeira, IV Ms. Sara Jane Fitzpatrick Mr. and Mrs. Keith L. Sachs Genentech, Inc. Edward Mallinckrodt, Jr. Foundation Mr. and Mrs. Richard J. Fox Mr. and Mrs. George U. Sauter Mrs. Samuel M. V. Hamilton March of Dimes Foundation Mr. and Mrs. Jeffrey S. French Schnader Harrison Segal & Lewis LLP Mr. and Mrs. Richard M. Horowitz G. Harold & Leila Y. Mathers Charitable Foundation Ms. Gail Kass and Mr. Roy Friedman Mr. and Mrs. K. George Schoeppner Mr. and Mrs. Ira M. Ingerman The Philadelphia Foundation Mr. and Mrs. William J. Friel, Jr. Mr. and Mrs. Roy Shapiro Jefferson Health System Mr. James R. Schaeffer Mr. Joel Gershman and Ms. Elaine Levitt Ms. Judith E. Soltz and Mr. Richard S. Belas Jewish Federation of Greater Philadelphia Mr. and Mrs. Bruce A. Gillespie Mr. and Mrs. John W. Sullivan Mr. and Mrs. Ronald J. Kozich Guarantor – ($10,000.00 + ) Mr. and Mrs. Stanley D. Ginsburg Susquehanna Foundation National Analysts, Inc American-Italian Cancer Foundation Ms. Staci Vernick Goldberg Mr. and Mrs. Barry E. Tague Dr. and Mrs. Paul Allan Offit Ms. Carol A. Ammon and Dr. Marie Pinizzotto Dr. and Mrs. Alfred E. Goldman Mr. and Mrs. Larry Tanenbaum Mr. Albert Ominsky, Esquire and Ms. Paula Dresnin Barra Foundation, Inc. Greater Philadelphia Chamber of Commerce Mr. and Mrs. Edward Tawil Philadelphia Phillies Mr. and Mrs. Robert S. Blank Mr. Joel K. Greenberg and Ms. Marcy Gringlas Mr. and Mrs. Gilbert Tucker Mr. and Mrs. David B. Pudlin BNY Mellon Wealth Management Dr. Jennifer Gross and Mr. Eli A. Gross Mr. and Mrs. Kevin M. Tucker RAF Industries Fred J. Brotherton Charitable Foundation Mr. Joseph F. Grusemeyer Mr. Stephen Tustin Mrs. Elsa Rhoads Mr. and Mrs. Ronald L. Caplan Mr. and Mrs. Norman L. Gutman UBS Financial Services Mr. and Mrs. William G. Rhoads Mrs. June H. Chern Hangley Aronchick Segal & Pudlin Universal Health Services, Inc. Mrs. Julia Rousso Mr. and Mrs. Winston Churchill Drs. Meenhard and Dorothee Herlyn University of the Arts Mr. and Mrs. Ronald Rubin Connelly Foundation Mr. and Mrs. Larry Holbert Mr. and Mrs. Richard A. Vermeil Mr. and Mrs. Paul J. Schmitt Cotswold Foundation Mr. and Mrs. Stephen J. Izzi Mr. and Mrs. Richard L. Weisberg Ms. Emily Brown Shields Mr. and Mrs. Brian H. Dovey Kaplan Pomerantz Schaeffer Foundation Mr. and Mrs. Mark Wilf Mr. and Mrs. Edward Sickles Mr. and Mrs. Stanley Druckenmiller Dr. and Mrs. Russel E. Kaufman Miss Caroline P. Wistar Fidelity Charitable Gift Fund Kristin and David Steinberg Foundation of CFNCR Mr. Gil Wistar Mr. and Mrs. Mark Fishman Mrs. Doris R. Taxin and Mr. Jack Stievelman Mr. Robert C. Wonderling GlaxoSmithKline Mr. and Mrs. Bryan S. Weingarten Mr. and Mrs. Richard D. Wood, Jr. Mr. and Mrs. Joseph A. Goldblum Mr. and Mrs. Laurence N. Weiss Mr. and Mrs. Bernard Zolot Mr. C. Cresson Wistar

24 WISTAR ANNUAL REPORT 2009 25 Associate – ($100.00 + ) Mr. and Mrs. Raymond J. Nolan Glorita Porreca-Maida Mrs. Edith R. Ackerman Mr. and Mrs. Roy T. Peraino Mr. and Mrs. Merrill Alderfer Mr. and Mrs. L. Stephan Perchick Ms. Nancy Allen Ms. Jennifer D. Powers Charitable Mr. Thomas J. Baldoni Mrs. Alberta D. Proietta Mr. and Mrs. Frederic L. Ballard, Jr. Mr. and Mrs. Joseph Ramsay Gift Annuities Mr. Paul Baskowsky Mrs. Robert Reichlin Mr. and Mrs. Robert L. Bast The Honorable Marjorie O. Rendell In this era of financial Charles J. Bauernschmidt, Esquire The Suzanne F. and Ralph J. Roberts Foundation uncertainty, Glorita Mr. James Beck Mrs. Howard H. Roberts Mrs. Murray Belman Mr. and Mrs. Burton Rosen Porreca-Maida, a retired Biohit, Inc. Mr. Donald M. Rosen schoolteacher from Joseph Boardman, Esquire Mr. and Mrs. Richard M. Rosenbleeth Tredyffrin Township, Pa., Mr. Daniel S. Bowerman Mr. and Mrs. Harold S. Rosenbluth Ms. Jo Ann Burke Mr. and Mrs. Joel Sackarowitz knows a sound place to Mr. and Mrs. Edward G. Bussinger Mr. Stanford Schaffer invest her money: The Mr. and Mrs. Robert B. Cahall Mr. Robert Schall Wistar Institute. Mr. and Mrs. Joseph Cahill Mr. Gustave Scheerbaum, III annual Benefactor – ($500.00 + ) Mr. and Mrs. William Schade Mr. and Mrs. Howard M. Casper Mr. and Mrs. Ronald H. Sherr The Charitable Gift Annuity Mr. Jack F. Adler, Jr. and Ms. Adelaide Beacham Franz W. Sichel Foundation Mrs. Curtis P. Chafee Ms. Leola V. Shumar program at Wistar allows Mr. and Mrs. I. Gary Bard Ms. Terri Smith Charitable Flex Fund Mr. and Mrs. Charles H. Silverman Giving Mr. Peter A. Benoliel and Ms. Willo Carey Mr. and Mrs. David L. Spooner Ms. Gwen A. Clendenning Mr. and Mrs. Alan P. Smith people to donate to the 2009 Mr. and Mrs. Edwin J. Berkowitz Mrs. Elise G. Sprunt Mr. and Mrs. Clyde Cutner Mr. and Mrs. S. Ty Steinberg Institute in exchange for Mr. Richard J. Braemer and Ms. Amy Finkel Ms. Bonnie Squires and Mr. Sami Ouahada Ms. Sheri X. De Cristofaro Mr. and Mrs. Samuel S. Stroud, Sr. a partial tax deduction Mr. Richard L. Brown and Ms. Kim D. Sichel Ms. Eunice Trevor Miss Clara S. Deily Ms. Francine Tabas Mrs. Barbara Cantor United Bank of Philadelphia Mrs. Louisa C. Dubin Tasty Baking Company and a lifetime stream Mr. and Mrs. Cummins Catherwood, Jr. Mr. and Mrs. Paul N. Urick Mrs. Virginia Burt Eppinger Mrs. Jean M. Taxin of annual income, an Mr. and Mrs. Robert Hacker Clapham, Sr. Mr. and Mrs. Jerry Wind Mr. Sam Epstein Ms. Georgine Tidmore important consideration Kathryn L. Connelly, Esquire Drs. William H. and Kathleen E. Wunner Ms. Roni L. Feierstein Mr. and Mrs. Philip Tigar Mr. and Mrs. Robert Cooper Ms. Jo-Ann Zoll Dr. and Mrs. Robert M. Fisher TKR Biotech Products, Inc. for an octogenarian. Ms. Joanne Davidow Mr. Barclay Fitzpatrick and Ms. Mary Jane Casavant Dr. Lynne Tobin Porreca-Maida follows Affiliate – ($250.00 + ) Mr. and Mrs. Samuel E. Dennis Mrs. Bernadette L. Foster Ms. Doina Todor Mr. and Mrs. Robert A. Bacine in the footsteps of her Mr. and Mrs. Leonard Dubin Ms. Amanda Freeman Dr. and Mrs. Lawrence W. C. Tom Mrs. Eileen Baird sister, Mathilda P. Fabrizio, Drs. Judith Wolf and Howard Eisen Mr. and Mrs. Joseph H. Friedrich Tosoh Bioscience, LLC Mr. and Mrs. Arthur Berkowitz Mr. and Mrs. Daniel E. Francis Ms. Elizabeth Gabor Howard S. Turner, Ph.D. who took part in a chari- Mrs. Dene K. Bernstein Mr. and Mrs. Benjamin Frankel Mr. and Mrs. Robert Gamberg Mr. and Mrs. James C. Vanderwaal Mr. and Mrs. Howard Bleznak table gift annuity with Mr. Richard L. Freundlich Mr. and Mrs. Henry A. Gladstone Mr. and Mrs. Herbert Victor Mr. and Mrs. Martin Brait Wistar before her death in Mr. and Mrs. P. Richard Frieder Mrs. Ellen Goldberg Wachovia Bank, N.A. Dr. and Mrs. T. Wister Brown Mr. and Mrs. Joseph L. Garde Mr. and Mrs. Anthony F. Goldsmith Mr. and Mrs. Morton B. Wapner 2007 at the age of 104. Kenneth J. Davis, Esquire Mr. and Mrs. Andrew A. Goldman Mr. and Mrs. Irwin Govberg Mrs. Helen B. Warner Mr. and Mrs. Edward Edelstein Mr. and Mrs. Alan Goodman Mr. Kenneth Guerino Mr. and Mrs. Leonard Wasserman “My late husband and Richard E. Fitzpatrick, M.D. Ms. Bonnie Grant Mrs. Patricia Guggenheim Mr. and Mrs. John C. Weidman, Jr. I were always practical with Mr. and Mrs. Stanton H. Friedman Mrs. Carole Haas Gravagno and Mr. Emilio Gravagno Mr. and Mrs. Mark Gushner Mr. Marvin Weinstein Ms. Joan Goldberg our money, and a charitable Harry B. Greenberg, M.D. Mr. and Mrs. Geoffrey Haynes Dr. Alan J. and Mrs. Margaret Ann Weir Mr. and Mrs. Richard H. Gwinn Diane E. Griffin, M.D. Dr. and Mrs. Scott H. Herbert Mr. and Mrs. Raymond H. Welsh gift annuity made sense Ms. Julia H. Hansbarger Mr. and Mrs. Gerald Gushner Ms. Lois Hockman Mr. and Mrs. Charles E. Will to me, especially with Mr. and Mrs. David A. Jenkins Mr. and Mrs. Gerard Hall Mr. Franklin Hoke Mr. and Mrs. Caleb C. Wistar, IV Mr. and Mrs. Jerry L. Johnson interest rates being what Mr. and Mrs. Christian M. Hoechst, Jr. The Honorable and Mrs. Harris N. Hollin Mr. Mayer Wolf Mr. and Mrs. Harvey Kimmel they are right now,” Ms. Anne Humes Miss Anna S. Jeffrey Mrs. Christine Wolosin Mr. and Mrs. Harvey S. Kronfeld Independence Blue Cross Mr. and Mrs. Jackson K. Kao Mr. and Mrs. John B. Wright Porreca-Maida said. “I get Leon Levy Foundation Mr. and Mrs. Alan D. Isen Mr. and Mrs. Ary L. Kaufmann Mr. and Mrs. Robert P. Levy a good rate of return and Dr. Ann Jeglum Mr. and Mrs. Jeffrey M. Knetsch Mr. and Mrs. Sam S. McKeel I take comfort in knowing Ms. Victoria Kaplan and Mr. Peter Dachowski Mr. and Mrs. Robert A. Lagas Mrs. Nikki L. Melso Dr. Judith Katz and Ms. Marilyn Arnott Mr. and Mrs. Emanuel Landau it supports cancer and Mr. Henry S. Miller, Jr. and Mr. Ken Nimblett Dr. Solomon Katz and Ms. Pauline A. Candaux Mr. Mark Latka vaccine research at Wistar.” Mr. and Mrs. Robert A. Miller Mr. Larry A. Keinath and Ms. Rosemary Spingler Mr. and Mrs. Ernest R. Leitenberger Dr. and Mrs. Patrick M. Oates Kimmel Cancer Center Mr. and Mrs. Ed Lipski Ms. Mae O’Neill Mrs. Lillian S. Kosloff Mr. William M. Macdonald Mr. and Mrs. Adolf A. Paier, Jr. Dr. Richard Kuhn Macy’s Foundation Mr. and Mrs. Arthur Pappas Mr. Alan Lerner and Ms. Adelaide Ferguson Mr. and Mrs. Lee Maimon Ms. Ronnie L. Pleet Mr. and Mrs. Jeffrey Scott Levitt Mrs. Pierre E. Martin Mr. and Mrs. Frank Pollera Mr. and Mrs. A. Bruce Mainwaring Ms. Janice K. Marx Mr. Steve Poses and Ms. Christina Sterner Mr. Kevin P. McDermott Merck Partnership For Giving Mr. and Mrs. Lawrence S. Reichlin Mr. and Mrs. Ronald J. Naples Mr. and Mrs. Kurtis L. Meyer Dr. Caroline S. Rhoads Mr. and Mrs. Robert Oppenheimer Mrs. Samuel W. Morris Mr. Samuel Vail Rhoads Mr. and Mrs. Peter F. Pecoraio Mr. and Mrs. Jack D. Moses Mr. Abraham R. Rosenkrantz * Clarence J. Peters, Ph.D. Mrs. Elizabeth Mulligan Mr. Joseph C. Sassa, III Philadelphia Convention & Visitors Bureau Ms. Leigh Murray Left: More than 200 guests honored Mr. and Mrs. Howard A. Silverman Wistar board member Ira Brind at the Mrs. Ann B. Ritt Sandya Narayanswami, Ph.D. Mrs. Betty F. Tomaselli 2009 Wistar Gala at The Rittenhouse. The Rittenhouse Foundation Ms. Dorothy Nicholson-Brown United Concordia (l to r) Lynne Honickman, Russel Mr. and Mrs. Ralph J. Roberts Dr. and Mrs. Leonard Warren Kaufman, Ira Brind, gala chair and Mr. Ed Rogers Reverend Jeff White Wistar board member Adele Schaeffer. Mr. and Mrs. Kevin Ross Mr. and Mrs. Alan B. Worthington Right: Arlene and Harvey Cherner Mr. Louis E. Rousso met Wistar scientists at a dinner Mr. Wayne D. Rowland and Ms. Denise DiPangrazio reception in Palm Beach, Florida. Dr. and Mrs. Karl F. Rugart, Jr. * Deceased

26 27 Wistar Family Gifts Mr. and Mrs. Frederic L. Ballard, Jr. The Charles J. Bauernschmidt, Esquire Mrs. Murray Belman Mr. Richard L. Brown and Ms. Kim D. Sichel Leadership Dr. and Mrs. T. Wister Brown Mr. and Mrs. Robert Hacker Clapham, Sr. Mr. and Mrs. Rodney D. Day, III Dr. and Mrs. Robert M. Fisher Council Mr. and Mrs. Geoffrey Haynes Mr. William M. Macdonald Mrs. Pierre E. Martin “ If your actions inspire others to dream more, Mr. and Mrs. Edward S. Morris Mr. and Mrs. I. Wistar Morris, III learn more, do more and become more, Wistar postdoctoral fellow Chunling Mrs. Samuel W. Morris you are a leader.”– John Quincy Adams Yi, Ph.D. (right), received the 2009 Dr. Caroline S. Rhoads Ching Jer Chen Memorial Award. Dr. and Mrs. Donald Vail Rhoads In 2007, The Wistar Institute board of trustees The award was established in memory Mrs. Elsa Rhoads of Wistar scientist Ching Jer Chen, Mr. Samuel Vail Rhoads brought together a group of volunteers to Ph.D., for the best scientific Mr. and Mrs. William G. Rhoads form the Leadership Council, a collection publication by a postdoctoral fellow Mrs. Howard H. Roberts of regional leaders who bring added vitality in 2009. June H. Chern, wife of Ms. Emily Brown Shields Spotlight on the late Dr. Chern, and Russel Mrs. Elise G. Sprunt to the Institute and strengthen its involvement E. Kaufman, M.D., join Yi for the Mr. and Mrs. Samuel S. Stroud, Sr. in the community. As the council’s chair, ceremony and memorial lecture. Dr. Alan J. and Mrs. Margaret Ann Weir board member Daniel Wheeler explains it, Mr. C. Cresson Wistar the Leaderhip Council is an excellent means Daniel Wheeler Mr. and Mrs. Caleb C. Wistar, IV Mr. Gil Wistar of expanding The Wistar Institute’s network In addition to chairing the Leadership Council, Having left public service, Wheeler is now Miss Caroline P. Wistar of support and raising its profile. Daniel Wheeler has been an integral member a private investor with an emphasis on real “The Leadership Council is a great way to of the Wistar board of trustees for the past ten estate. He lives with his wife and two children Wistar heritage bring in quality people who want to be part years. His commitment to Wistar and dedication in Wynnewood. of the Institute’s family,” Wheeler said. to its growth have driven his deep involvement For all of its other benefits, says Wheeler, serving society “The council allows them to get involved in board activities. He chairs the board’s on the Wistar board is also an act of enlightened immediately and helps us extend our government relations sub-committee, serves The Wistar Heritage Society is comprised self-interest. “I like to be around smart people,” he connection to the community.” on its building committee, and acts as the of individuals who elect to perpetuate their said. “Our board members are incredibly impres- support of biomedical research by including board’s liaison to the Leadership Council, bringing The opportunities for involvement are sive, and I’m in awe of the work our scientists do. the Institute in their wills or estate plans. the ideas and recommendations of that group numerous. Council members serve on It’s humbling.” Wheeler also admires the collegial to the trustees as a whole. Francis X. Bresnan committees of the board of trustees, such atmosphere at Wistar nurtured by its president, Ira Brind as those that offer guidance for government An attorney by profession, Wheeler practiced Russel E. Kaufman, M.D. We’re all here for the June H. Chern Peter E. Corrado relations and fundraising. The council also law in Philadelphia for ten years before joining same reason,” he said. “Cancer touches everyone. Harold M. Davis holds events designed to broaden Wistar’s Pennsylvania Governor Edward G. Rendell’s If it hasn’t touched you yet, it will some day. I sleep Julia A. Felton community engagement, and recently hosted administration in Harrisburg where he served better at night knowing that I am trying to help.” Dr. Jerome I. Flicker a reception for Wistar’s annual Nikon Dr. and Mrs. Alfred E. Goldman for a time as deputy secretary for property Mr. and Mrs. Bruce A. Goodman Small World exhibition of stunning photo- management in the Department of General Meenhard Herlyn, D.V.M., D.Sc. graphs taken through a microscope. Services. Governor Rendell then named Wheeler Dorothee M. Herlyn, D.V.M., D.Sc. The Honorable Harris N. Hollin “ In just a few short years, the Leadership as director of the Governor’s Action Team, Mrs. Constance Jordan Council has become a great asset for Wistar, giving him primary responsibility for job creation Miss Rivka Kaestner and corporate investment in Pennsylvania. Russel E. Kaufman, M.D. enabling us to bring in fresh eyes and new Herbert Kean, M.D. skill sets to help guide and advise,” Wheeler Hilary Koprowski, M.D. said. “The members are true leaders who Kurtis L. Meyer Paula R. Meyer want to help, and have the ability to make Sandya Narayanswami, Ph.D. a real impact.” Elizabeth A. Pesce Timothy P. Pesce Lt. Col. Carolyn Reinbold Karl F. Rugart, Jr., M.D. Emily Brown Shields Family of Stephen M. Shoyer Ann G. Sickles Edward Sickles Howard S. Turner, Ph.D. James B. Wistar Joan H. Wister

28 29 in honor of…

Beanie Blum’s 80th birthday Faye Kozich Mr. and Mrs. Sylvan M. Tobin Mr. and Mrs. Stuart Peltz Mr. and Mrs. Harold Schaeffer Evie Krancer Ira Brind Mrs. Shelley Greenbaum Mr. and Mrs. Leonard Dubin Julian Krinsky’s special birthday Linda Broder’s 60th birthday Mr. and Mrs. Harold Schaeffer Dr. Susan Schwartz McDonald Tina Krinsky’s special birthday and Mr. Graham McDonald Mr. and Mrs. Harold Schaeffer Mr. and Mrs. Harvey Cherner’s Albert Ominsky 50th wedding anniversary Mr. and Mrs. Leonard Dubin Mr. and Mrs. Harold Schaeffer Christopher Pakuris Peter Corrado and family Mr. and Mrs. Edward Edelstein Mr. Wayne D. Rowland and Ms. Denise DiPangrazio Marcia Perlmutter’s 70th birthday Steve Cozen’s 70th birthday Mr. and Mrs. Ronald J. Kozich Mrs. Vera Resnik Tim and Elizabeth Pesce Sara Jane Fitzpatrick’s special birthday Mr. and Mrs. Ed Lipski Mr. and Mrs. Peter E. Corrado Ms. Danielle Corrado Mrs. David Pudlin Philip Corrado Mr. and Mrs. Howard A. Silverman Jaime Corrado Mr. Joel K. Greenberg and Ms. Marcy Gringlas Mr. Barclay Fitzpatrick and Ms. Mary Jane Casavant Shirley Shelman Making a Habit of Giving Joseph Garde’s special birthday Mr. and Mrs. Sylvan M. Tobin Mr. and Mrs. Harold Schaeffer Ed Edelstein’s first encounter with The Wistar Institute goes back 50 years to the day he, then a Mr. and Mrs. Arthur Stotter’s Lenore Gerson’s 75th birthday 60th wedding anniversary University of Pennsylvania law student, paid Wistar a visit that he would remember for the rest of his life. Mr. and Mrs. Irwin Govberg Mr. and Mrs. Robert Gamberg In the days before drugstore pregnancy tests, the pragmatic young Edelstein turned to his campus Michael and Antonia Goldberg’s wedding Doris Taxin’s engagement to Jack Stievelman neighbors — fertility researchers at Wistar — for a prenatal prediction. The news he would be a father, Ms. Jamie Moss Mrs. Julia Rousso he says, “Made my whole day, and I’d never forget what they did for me at Wistar.” Shelly and Irv Govberg’s anniversary Mr. and Mrs. Fred Teece’s Years later, when Herbert Kean, M.D., (see page 13) told him of the fund that he was putting together Mr. Donald M. Rosen 50th wedding anniversary Mr. and Mrs. Harold Schaeffer in honor of Jeannette Kean, he thought back to that first experience and decided to also join him in Todd Holbert’s wedding supporting Wistar. Since then, Edelstein has made it a point to encourage others to donate to the Mr. and Mrs. Laurence Holbert Fran Tobin Dr. and Mrs. Marc H. Holbert Mrs. Shelley Greenbaum Institute. Edelstein himself has made 66 gifts in honor of and in memory of friends and family, including Mr. Michael Holbert a donation in the memory of his daughter, Heidi Augustino, who died of breast cancer in 2001. Mr. Matthew Holbert Sylvan Tobin’s special birthday Mr. and Mrs. Mark Fishman Ira Ingerman Mr. Mark Latka Mr. Marvin Weinstein Mr. and Mrs. Burton Rosen Selma and Terry Katz’s birthdays Mr. and Mrs. Sylvan Tobin Mrs. Jean M. Taxin Ms. Ronnie L. Pleet Herb Kean Mr. and Mrs. Joseph F. Ladzenski Herbert Kean on the occasion of the appointment of the Herbert Kean, M.D., Family Professorship Mr. Leroy E. Kean Mrs. Helene Kendall’s 70th birthday Mr. and Mrs. Irwin Govberg Mr. Philip J. Kendall’s special birthday Mr. and Mrs. Harold Schaeffer Kathy Kerwin Ms. Barbara D. McCarthy

30 30 WISTAR ANNUAL REPORT 2009 31 In Memoriam Abraham in MEMORY of… Rosenkrantz To those who knew him best, Abraham Rosenkrantz was a passionate man. His family describes him as a gifted salesman who loved Eric Abanquah Warren Cheston Norman Hockman Jonathan Leibowitz Larry Shaiman to talk and to share with Meryle J. Melnicoff, Ph.D. Mr. and Mrs. Kurtis L. Meyer Mrs. Eileen Baird Mr. Leroy E. Kean Mr. Albert Ominsky, Esquire and Ms. Paula Dresnin others his passion for work, Mr. and Mrs. Irwin Govberg Dorothy Abrams Howard Cohen Robert E. Leitenberger Khairi Shakur Mr. and Mrs. Sylvan M. Tobin for life, and his passion for Mrs. Eileen Baird Mr. and Mrs. Richard M. Horowitz Mr. and Mrs. Ernest R. Leitenberger Mr. and Mrs. Richard M. Horowitz family. When he died at the Rita Hoffman Alvin S. Ackerman, Esquire Joseph Cooper Alvin Leonard Nicole Siddons Ms. Frances Wenger age of 94, his family knew Mrs. Edith R. Ackerman Mr. and Mrs. John Martino The Honorable and Mrs. Harris N. Hollin Mr. and Mrs. Ronald J. Kozich that, in lieu of flowers, his Mrs. Jean M. Taxin Constance Howe Bernard Adler Gene Lerner Sam Sidewater’s mother Mr. and Mrs. Richard Horowitz friends and family could Mr. and Mrs. Edward Edelstein Vincent J. Cristofalo, Ph.D. Ms. Sandy Taxin Mr. and Mrs. Irwin Govberg best honor him by supporting Mr. and Mrs. Michael Carney Mrs. Margaret F. Cristofalo Susan Schultz Claire Levine Susan Spiegel Mr. and Mrs. Leonard A. Jackowski another of his passions: Peggy Amsterdam Christopher Davis Mr. and Mrs. Richard Schatz Mr. and Mrs. Richard Schatz The Wistar Institute. Mr. and Mrs. Lee Maimon Mr. and Mrs. K. George Schoeppner Sam Jacobs Elizabeth Liburdi Joyce Stone Mr. and Mrs. Irwin Govberg Mr. and Mrs. Richard H. Gwinn Mr. and Mrs. Edward Tepper Mr. and Mrs. Douglas S. Briggs Mr. Albert Ominsky, Esquire and Ms. Paula Dresnin Rosenkrantz and his family Maureen Angevine Jerry Feig Elizabeth Kabler’s mother Salvatore Malvestuto Nancy Tannenbaum had long been friends of Ms. Rhoda Rothcopf Mrs. Jean M. Taxin Mr. and Mrs. Harold Schaeffer Mr. and Mrs. Richard M. Horowitz Mr. and Mrs. John Martino Wistar, an association that Donald Baird Edward Felbin Sonny Kagan’s sister Lillian Mitman Edward Taxin began when his daughter, Mrs. Eileen Baird Mrs. Jean M. Taxin Ms. E. K. Pomerantz and Mr. Leslie Miller Mr. and Mrs. C. Lawrence Rutstein Mrs. Jean M. Taxin Elaine Ominsky, was Lisa Ann Baird Andrew Flicker Arthur Kaplan Larry Murdoch Genevieve Toll’s grandmother diagnosed with breast Mrs. Eileen Baird Dr. and Mrs. Jerome I. Flicker Mr. Leo Snowiss Mr. and Mrs. Peter E. Corrado Mr. and Mrs. Edward Edelstein Ms. Susan Mitnick cancer. The family toured Wilma Banet John F. Ford Carol Murphy’s father Phyllis Weiner the Institute, and soon Mr. and Mrs. Irwin Govberg Mr. and Mrs. Ronald J. Kozich Elizabeth Keator Mr. and Mrs. Edward Edelstein Mr. and Mrs. Robert Gamberg Mr. and Mrs. Dwight L. Beucler became impressed by Stephen Barcus Willie C. Freeman Mr. and Mrs. Joseph Cahill Lillian Nelson’s sister Phyllis Barbara Rose Wheeler Wistar’s history of accom- Ms. Sandy Taxin Amanda Freeman Mrs. Curtis P. Chafee Mrs. Eileen Baird Mr. and Mrs. Richard M. Horowitz plishments and the Lila Batt Lester Fry Sr. Ms. Jane M. Dearnley Paul Panepinto, Sr. Elayne Weisberg’s mother potential of its current Mrs. Eileen Baird Mr. and Mrs. Ronald J. Kozich Charlene Grant and Inell Wilson Mr. and Mrs. John Martino Mr. and Mrs. Harold Schaeffer Ms. E. K. Pomerantz and Mr. Leslie Miller Mr. and Mrs. Robert J. Kyle research programs. Allan Getson Mr. and Mr. Frederick Lenning, III Irv Penner Caesar Williams, Sr. Burton Beifeld Mr. Albert Ominsky, Esquire and Ms. Paula Dresnin Elaine died in 1997, the Ms. Mary E. Spence Mrs. Eileen Baird Dr. and Mrs. Brent Weinerman Mrs. Jean M. Taxin Lee Glazer Mr. and Mrs. Frank Szabo same year as her mother, Leo Roselli Jane Wills Stanton Berger Mr. and Mrs. John Martino Mr. W. Scott Tuttle Mr. and Mrs. Kevin M. Tucker Mr. and Mrs. Sylvan M. Tobin Ruth Rosenkrantz, who Ms. E. K. Pomerantz and Mr. Leslie Miller Toby Goldfarb William Keith also succumbed to breast Hilda Rothberg Jerry Winter Sara Bornstein Mr. and Mrs. Robert Gamberg Ms. E. K. Pomerantz and Mr. Leslie Miller Mrs. Jean M. Taxin Mrs. Eileen Baird cancer. In her name, Mr. and Mrs. Ronald J. Kozich Louis Goldfine Neil Kenyon Elaine’s husband, Albert Richard Rovner Connie Wolf Marty Bosses Mr. and Mrs. Harold S. Rosenbluth Dr. Herbert Kean and The Honorable Joyce Kean Mr. and Mrs. Harold Schaeffer Mrs. Eileen Baird Ominsky, now a member Mr. and Mrs. Irwin Govberg Marilyn Gushner’s brother Stanley Charles King Mr. and Mrs. Bernard Zolot of the Wistar board of Nina Rubinsohn Leonard Boxer Mr. and Mrs. Irwin Govberg Mrs. Vera Resnik Mr. and Mrs. Harold S. Rosenbluth James Woy trustees, established a fund Mr. and Mrs. Irwin Govberg Mr. and Mrs. Nick Lanuti Marion Heine Mrs. Eileen Baird to support Wistar research. Ruth Sacks Burton Burnstein Dr. and Mrs. Jerome I. Flicker Lane King Ms. E. K. Pomerantz and Mr. Leslie Miller Sandra Zaslow Mr. and Mrs. Ronald J. Kozich Mr. and Mrs. Jon S. Kean “We saw Wistar as a place Don Helm Mr. and Mrs. Harold S. Rosenbluth Mrs. Frankie Schultz’s sister Barry Calder Mr. and Mrs. Kevin M. Tucker Mrs. Audrey Kleinfeld’s son where the next clinical trial Mr. and Mrs. Leonard A. Jackowski Mrs. Pierre E. Martin Ms. E. K. Pomerantz and Mr. Leslie Miller could come from, the next Brenda Hewit Leroy Seftel Mary N. Cash Mr. and Mrs. Sylvan M. Tobin Joeanne Kunik’s mother big research development,” Mrs. Vera Resnik Mrs. Elise G. Sprunt Mr. and Mrs. Harold Schaeffer Mrs. Eileen Baird said Eunice Trevor, Angelo Cesarini Emanuel Landau’s brother Rosenkrantz’s daughter. Mr. and Mrs. Richard M. Horowitz Mr. and Mrs. Sylvan M. Tobin “We knew that our donations to Wistar would go directly to research, to support scientists in a way that will allow them to pursue their creativity and passions.”

32 33 Paul V. Cherington, Ph.D. Molecular and Cellular Oncogenesis Ramana Davuluri, Ph.D. Paul A. Offit,M .D. Associate Director for Shared Facilities Associate Director and Director Children’s Hospital of Philadelphia Russel E. Kaufman, M.D. Professors of Computational Biology President and CEO Marianne O’Neill Meenhard Herlyn, D.V.M., D.Sc., Program Leader Reynold A. Panettieri, Jr., M.D. Larry Keinath, C.P.A. Associate Director for Cancer Center David W. Speicher, Ph.D., D.Sc., Co-Program Leader University of Pennsylvania Support Grant Finances Ellen Heber-Katz, Ph.D. The Wistar Institute Center for Chemical Vice President for Finance and Administration George C. Prendergast, Ph.D. Russel E. Kaufman, M.D. Biology and Translational Medicine 2 Lisa Sideras Lankenau Institute for Medical Research John J. Lucas, Ph.D. Ellen Puré, Ph.D. Associate Director for Cancer Center Administration Paul M. Lieberman, Ph.D. Vice President for Academic Affairs Louise C. Showe, Ph.D.1 Thomas D. Stamato, Ph.D. Director Lankenau Institute for Medical Research Elizabeth O’Brien, Esq. The Wistar Institute Cancer Center Associate Professors Vice President for Legal and External Affairs Research Programs Ramana Davuluri, Ph.D. The Wistar Institute Albert R. Taxin Wolfgang Weninger, M.D. Ellen Puré, Ph.D. Philadelphia Healthcare Trust Professor Brain Tumor Research Center University of Sydney Gene Expression and Regulation Professor and Associate Vice President Harold C. Riethman, Ph.D. John H. Wolfe, V.M.D., Ph.D. Members for Academic Affairs Professors Assistant Professors Nadia Dahmane, Ph.D. University of Pennsylvania Ronen Marmorstein, Ph.D., Program Leader Nadia Dahmane, Ph.D. Joseph L. Kissil, Ph.D. Shelley Berger, Ph.D.2 Qihong Huang, M.D., Ph.D. Adjunct Associate Professors Hilary Koprowski, Professor Joseph L. Kissil, Ph.D. The Wistar Institute Robert A. Fox Horace M. DeLisser, M.D. Paul M. Lieberman, Ph.D. Carlton C. Maley, Ph.D. Administrative Staff Gerd Maul, Ph.D. Structural Biology Center University of Pennsylvania Senior Staff Scientists staff Paul V. Cherington, Ph.D. Kazuko Nishikura, Ph.D. K. Ann Jeglum, V.M.D. Kiranmai Gumireddy, Ph.D. Members and Director of Science Administration Frank J. Rauscher, III, Ph.D. Ronen Marmorstein, Ph.D. Veterinary Oncology Services and Research Center Ramin Shiekhattar, Ph.D. Michele Jacob, Ph.D. Peter E. Corrado Michael Showe, Ph.D. Emmanuel Skordalakes, Ph.D. Steven B. McMahon, Ph.D. Herbert Kean, M.D., Family Professor administration Director of Institutional Development Thomas Jefferson University Associate Professors Staff Scientists Professor Laureate Staci Vernick Goldberg Laszlo Otvos, Ph.D., D.Sc., C.B.A. Jumin Zhou, Ph.D. Mizuho Kalabis, Ph.D. Director of Communications Hyunsoo Kim, Ph.D. Hilary Koprowski, M.D. Temple University Assistant Professors Nina Long, M.L.S. John Lee Jr., Ph.D. Susan Janicki, Ph.D. Elena Nikonova, M.D.2 Director of Library Services and Curator Professors Emeriti Adjunct Assistant Professors Ken-ichi Noma, Ph.D. Hsin-Yao Tang, Ph.D. of The Wistar Museum Collections Peter D. Adams, Ph.D. Emmanuel Skordalakes, Ph.D. Tao Wang, M.D., Ph.D. Clayton A. Buck, Ph.D. Meryle J. Melnicoff, Ph.D. Roger M. Burnett, Ph.D. Fox Chase Cancer Center Staff Scientists Associate Staff Scientists Director of Business Development Walter Gerhard, M.D. Devraj Basu, M.D., Ph.D. Zhong Deng, Ph.D. Valerie Baubet, Ph.D. Elliot M. Levine, Ph.D. University of Pennsylvania Jo-Ann Mendel, M.B.A. Dimitri Negorev, Ph.D. Linda Hanlon, Ph.D.2 Stanley A. Plotkin, M.D. 2 Director of Human Resources Brandon Placek, Ph.D. Won-A Joo, Ph.D. Robert Roosa, Ph.D. Michael R. Betts, Ph.D. Hongzhuang Peng, Ph.D. 2 Marianne O’Neill Angelica Santos, Ph.D. Leonard Warren, M.D., Ph.D. University of Pennsylvania Yong Tang, Ph.D. Chunling Yi, Ph.D. Director of Grants and Contracts Administration Zofia Wroblewska, M.D. F. Bradley Johnson, M.D., Ph.D. Associate Staff Scientists Jessie Villanueva, Ph.D. Raymond Preis University of Pennsylvania David Baillat, Ph.D. Adjunct Faculty Director of Information Systems Eric Meggers, Ph.D. Jayaraju Dheekollu, Ph.D. The Wistar Institute Cancer Center Harold C. Riethman, Ph.D. Zhoayuan Hou, Ph.D. Shared Facilities Adjunct Professors Philipps-University of Marburg Associate Director of Training Fang Lu, Ph.D. Steven M. Albelda, M.D. Julia C. Tchou, M.D., Ph.D. Shared Facility Scientific Directors Pu Wang, Ph.D. University of Pennsylvania University of Pennsylvania Kenneth J. Sulkowski Ramana Davuluri, Ph.D. Jing Zhou, Ph.D.2 Director of Facilities Jan Erikson, Ph.D. Richard Assoian, Ph.D. External Scientific Advisory Committee Stephen E. Tustin, C.P.A. Luis J. Montaner, D.V.M., D.Phil. University of Pennsylvania Immunology Louise C. Showe, Ph.D. Director of Finance Shelley Berger, Ph.D. Chair Ellen Heber-Katz, Ph.D. Professors University of Pennsylvania Edward Ziff, Ph.D. William H. Wunner, Ph.D. Hildegund C.J. Ertl, M.D., Program Leader Joseph L. Kissil, Ph.D. New York University School of Medicine Director of Outreach for Education Andrew J. Caton, Ph.D. Paul M. Lieberman, Ph.D. Timothy M. Block, Ph.D. Members and Technology Training Programs Jan Erikson, Ph.D. David W. Speicher, Ph.D. Drexel University Dorothee Herlyn, D.V.M., D. Sc. Riccardo Dalla-Favera, M.D. Shared Facility Directors Anthony Capobianco, Ph.D. The Wistar Institute Cancer Luis J. Montaner, D.V.M., D. Phil. Herbert Irving Comprehensive Cancer Center Celia Chang, Ph.D. University of Miami Center Administration Louise C. Showe, Ph.D. Denise DiFrancesco, A.S., R.L.A.T., I.L.A.M., C.M.A.R. H. Fred Clark, D.V.M., Ph.D. Olivera J. Finn, Ph.D. Russel E. Kaufman, M.D. Assistant Professors Zhiyan Fu, Ph.D. Children’s Hospital of Philadelphia University of Pittsburgh School of Medicine Ping Jiang, M.D. Director Hui Hu, Ph.D. Todd R. Golub, M.D. E. John Wherry, Ph.D. John Rux, Ph.D.2 Dennis E. Discher, Ph.D. Frank J. Rauscher, III, Ph.D. The Broad Institute of MIT and Harvard David Schultz, Ph.D. University of Pennsylvania Deputy Director for Basic Research Senior Staff Scientists Hao Sun, Ph.D.2 Peter E. Lipsky, M.D. Livio Azzoni, M.D., Ph.D. Chaitanya R. Divgi, M.D. Meenhard Herlyn, D.V.M., D.Sc. National Institute of Arthritis and Jihed Chehimi, Ph.D. Shared Facility Managers University of Pennsylvania Deputy Director for Translational Research Musculoskeletal and Skin Diseases Emmanouil Papasavvas, Ph.D. Jeffrey S. Faust, M.B.A. Wafik S. El-Deiry, M.D., Ph.D. Ronen Marmorstein, Ph.D. Rajasekharan Somasundaram, Ph.D. James Hayden, B.A., R.B.P., F.B.C.A. University of Pennsylvania Lynn M. Matrisian, Ph.D. Program Leader – Gene Expression and Regulation Rolf Swoboda, Ph.D. Kaye D. Speicher Vanderbilt University Zhi Quan Xiang, M.D. David E. Elder, M.B., Ch.B., F.R.C.P.A. Hildegund C.J. Ertl, M.D. Joseph S. Pagano, M.D. Tianqian Zhang, Ph.D.2 University of Pennsylvania Program Leader – Immunology The Wistar Institute Vaccine Center University of North Carolina Xiang Yang Zhou, Ph.D. Nigel W. Fraser, Ph.D. Lineberger Comprehensive Cancer Center Meenhard Herlyn, D.V.M., D.Sc. Hildegund C.J. Ertl, M.D. Staff Scientists University of Pennsylvania Program Leader – Director Hidde Ploegh, Ph.D. Marcio Lasaro, Ph.D. Molecular and Cellular Oncogenesis Phyllis A. Gimotty, Ph.D. Whitehead Institute for Biomedical Research Costin Tomescu, Ph.D. The Wistar Institute Center for Systems University of Pennsylvania David W. Speicher, Ph.D. Dongming Zhou, Ph.D. Danny Reinberg, Ph.D. Co-Program Leader – and Computational Biology Mark I. Greene, M.D., Ph.D., F.R.C.P. New York University School of Associate Staff Scientists University of Pennsylvania Molecular and Cellular Oncogenesis David W. Speicher, Ph.D. Medicine Smilow Research Center Hua Li, M.D. Thanos D. Halazonetis, D.D.S., Ph.D. Brian Hondowicz, Ph.D.2 Director Richard A. Young, Ph.D. University of Geneva Louise C. Showe, Ph.D. Whitehead Institute for Biomedical Research Associate Director and Director of Genomics Katherine A. High, M.D. Children’s Hospital of Philadelphia 1 Secondary appointment 2 Departed, 2009

34 WISTAR ANNUAL REPORT 2009 35 OFFICERS Herbert Kean, M.D. Daniel H. Wheeler, Chair Patrick M. Oates, Ph.D. board of The Leadership PRWT Services, Inc./Cherokee Pharmaceuticals Brian H. Dovey Hilary Koprowski, M.D. Max Berger trustees Chair Professor Council MBA Equities, Ltd. Elizabeth A. Pesce Thomas Jefferson University Beco-Designs 1 Eric Bernstein, M.D. Harold M. Davis Professor Laureate Main Line Center for Laser Surgery Kristi M. Poling, Esq. Co-vice chair The Wistar Institute Dilworth Paxson, LLP Erin Murphy Boyle Helen P. Pudlin, Esq. Faye S. Olivieri Kozich Co-vice chair Governor’s Action Team Edward J. Ryan Dan W. Matthias Citizens Bank Doris Taxin Arnon Dreyfuss, M.D. Secretary Susan S. McDonald Jim Schaeffer Elizabeth Gabor CEO Ruby’s of Pennsylvania 2 Philadelphia Industrial Development Corporation Ian J. Berg National Analysts Worldwide Treasurer Paul N. Urick, R.Ph. Keith Gaspard Maida Milone, Esq. Independence Blue Cross/FutureScripts Life Sciences Diversified Search Albert Ominsky, Esq. Aubrey Watkins MEMBERS Joseph A. Goldblum Ominsky and Ominsky, P.C. Merck & Company Ian J. Berg2 G-II Equity Investors, Inc. Seymour S. Preston, III Bryan Weingarten Managing Director Scott H. Herbert, M.D. The Millrace Group WP Realty ETF Venture Funds The Rosenfeld Cancer Center Robert S. Blank Helen P. Pudlin Abington Memorial Hospital Executive Vice President and General Counsel Partner Larry Hollin The PNC Financial Services Group Whitcom Partners Independence Capital Partners Samuel V. Rhoads4 Dani P. Bolognesi, Ph.D. Richard M. Horowitz Senior Vice President Chairman and CEO R.A.F. Industries, Inc. B3Bio, Inc. Philadelphia Industrial Development Corporation Sharon Kestenbaum Robert H. Rock Douglas S. Briggs Fishman & Tobin President Ira Brind MLR Holdings, LLC Kevin P. McDermott, CFP®, RFC President The Philadelphia Group Brind Investments, Inc. Gerald B. Rorer William Y. Brown3 Adele K. Schaeffer President and CEO Paul J. Schmitt Academy of Natural Sciences Managing Director Ronald Caplan Novitas Capital President and CEO Edward Sickles1 Philadelphia Management Corporation Judith E. Soltz, Esq.3 Harold M. Davis Chairman Arthur L. Stokes, M.D. Realen Properties Doris Taxin Brian H. Dovey Kevin M. Tucker General Partner Domain Associates George J. Vergis, Ph.D. Richard E. Fitzpatrick, M.D. David V. Wachs Director of Cosmetic Dermatology Daniel H. Wheeler La Jolla Cosmetic Surgery Centre Robert A. Fox Chairman and CEO 1 Emeritus, effective January 2010 R.A.F. Industries, Inc. 2 Deceased, December 2009 3 Representative of the Academy of Natural Sciences, Richard M. Horowitz elected according to the terms of the Deeds of Trust President 4 Wistar family representative, elected according R.A.F. Industries, Inc. to the terms of the Deeds of Trust

36 Embracing Evolution Meeting New Challenges for Science and Society

3601 Spruce Street Philadelphia, PA 19104-4265 215.898.3700 www.wistar.org The Wistar Institute’s 2009 Annual Report was produced by the Office of Communications. Staci Vernick Goldberg, Director of Communications Greg Lester, Editor Design: GHI Design Principal photography: Tommy Leonardi. Additional photography: The Wistar Institute Archives, James Hayden, Fred Keeney, Janis Bucher, iStock Photo

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© Mixed Sources Product group from well managed forests, controlled sources and recycled wood or fiber 38 www.fsc.org Cert no. SGS-COC-003409 © 1996 Forest Stewardship Council

© Mixed Sources Product group from well managed forests, controlled sources and recycled wood or fiber www.fsc.org Cert no. SGS-COC-003409 © 1996 Forest Stewardship Council