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ACTR1A polyclonal antibody

Catalog: BS6315 Host: Rabbit Reactivity: Human,Mouse,Rat

BackGround: P61163 The complex is a macromolecular complex that Purification&Purity: consists of 10-11 distinct subunits. This complex is criti- The antibody was affinity-purified from rabbit antiserum cal for the function of , a molecular motor . by affinity-chromatography using epitope-specific im- Dynactin plays a role in ER to Golgi transport, spindle munogen and the purity is > 95% (by SDS-PAGE). formation, movement, axon guidance, nu- Applications: clear positioning and the centripetal movement of lyso- WB 1:500 - 1:2000 somes and endosomes. Centractin is a subunit of the Storage&Stability: dynactin complex that exists in multiple isoforms. The α Store at 4°C short term. Aliquot and store at -20°C long isoform, also known as -related protein 1 homolog A term. Avoid freeze-thaw cycles. (Arp1) and previously referred to as centractin, is the Specificity: most abundant isoform in the dynactin complex. The β ACTR1A polyclonal antibody detects endogenous levels isoform, also known as actin-related protein 1 homolog of ACTR1A protein. B, shares 90% identity with the α isoform. The two DATA: isoforms, α and β, are expressed at a ratio of 15:1 respec- tively. The backbone filament structure of the dynactin complex (important for the arrangement of other complex ) is composed of 9-11 subunits of α/β-centractin. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,

50% glycerol, pH7.2 Molecular Weight: WesternBlot (WB) analysis of ACTR1A polyclonal antibody ~ 43 kDa Note: Swiss-Prot: For research use only, not for use in diagnostic procedure.

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