CDH8 Antibody Cat. No.: 57-427

CDH8 Antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDH8 antibody , which was peroxidase- conjugated to the secondary antibody, followed by DAB staining.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This CDH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 33-63 amino acids from the N-terminal region of human CDH8.

TESTED APPLICATIONS: IHC-P, WB

For WB starting dilution is: 1:1000 APPLICATIONS: For IHC-P starting dilution is: 1:10~50

PREDICTED MOLECULAR 88 kDa WEIGHT:

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This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: CDH8

ALTERNATE NAMES: Cadherin-8, CDH8

ACCESSION NO.: P55286

PROTEIN GI NO.: 13432121

GENE ID: 1006

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular BACKGROUND: domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

REFERENCES: 1) Blaschke,S., Int. J. Cancer 101 (4), 327-334 (2002)

2) Shimoyama,Y., Biochem. J. 349 (PT 1), 159-167 (2000)

ANTIBODIES FOR RESEARCH USE ONLY.

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