Assessment of Use of Combined Dextromethorphan and Quinidine In

Supplementary Online Content

Fralick M, Sacks CA, Kesselheim AS. Assessment of use of combined dextromethorphan and quinidine in patients with dementia or Parkinson disease after US Food and Drug Administration approval for pseudobulbar affect. JAMA Intern Med. Published online January 7, 2018. doi:10.1001/jamainternmed.2018.6112

eTable 1. Covariate Definitions: Diagnosis Codes

eTable 2. Covariate Definitions: Medications Used and Indications

eReferences.

This supplementary material has been provided by the authors to give readers additional information about their work.

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eTable 1. Covariate Definitions: Diagnosis Codes Code ICD-9 ICD-10 (Inpatient & Outpatient) (Inpatient & Outpatient) Identified up to 1000 days before index date and up to 30 days after ALS1 335.2* G12.2* MS2 340 G35 Dementia or 290.0, 290.1, 290.10, 290.11, F01.*, F02.*, F03.*, Parkinson 290.12, 290.13, 290.2, 290.20, G30.*, G20.*, G31.0, Disease3 290.21, 290.3, 290.4, 290.40, G31.01, G31.09, G31.1, 290.41, 290.42, 290.43, 290.8, G31.8, G31.83, G31.89, 290.9, 294.0, 294.1, 294.10, G31.9 294.11, 294.2, 294.20, 294.21, 294.8, 294.9, 330.0, 330.1, 330.2, 330.3, 330.8, 330.9, 331.0, 331.1, 331.11, 331.19, 331.2, 331.3, 331.4, 331.5, 331.6, 331.7, 331.8, 331.81, 331.82, 331.89, 331.9, 332, 332.1 Identified up to 365 days before the index date Stroke 430*, 431*, 433*, 434*, 436* I60*, I61*, I63* I65*, I66* Ischemic heart 411.0, 411.81, 412, 429.7, 410, I20.*, I21.*, I22.*, I23.*, disease 410.0, 410.00, 410.01, 410.02, I24.*, I25.* 410.1, 410.10, 410.11, 410.12, 410.2, 410.20, 410.21, 410.22, 410.3, 410.30, 410.31, 410.32, 410.4, 410.40, 410.41, 410.42, 410.5, 410.50, 410.51, 410.52, 410.6, 410.60, 410.61, 410.62, 410.7, 410.70, 410.71, 410.72, 410.8, 410.80, 410.81, 410.82, 410.9, 410.90, 410.91, 410.92, 414, 414.0, 414.00, 414.01, 414.02, 414.03, 414.04, 414.05, 414.06, 414.07, 414.1, 414.10, 414.11, 414.12, 414.19, 414.2, 414.3, 414.4, 414.8, 414.9 Hypertension 401.*- 405.* I10*, I11.*, I12.*, I13.*, I15.* Heart failure 428.*, 398.91, 402.01, 402.11, I50.* 402.91, 404.01, 404.11, 404.91, 404.03, 404.13, 404.93

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Downloaded From: https://jamanetwork.com/ on 09/29/2021 eTable 2. Covariate Definitions: Medications Used and Indications Indication Medication identified within 30 days of index date) Dementia or donepezil, ergoloid mesylates, galantamine, memantine, Parkinson related memantine/donepezil, rivastigmine, rivastigmine tartrate, tacrine, amantadine, benztropine mesylate, biperiden, carbidopa, carbidopa/levodopa, levodopa, pergolide mesylate, pramipexole, procyclidine, rasagiline mesylate, ropinirole, rotigotine, selegiline, tolcapone, trihexyphenidyl Benzodiazepines alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, estazolam, flurazepam, halazepam, lorazepam, midazolam, oxazepam, quazepam, temazepam, triazolam Anxiolytic/hypnotic buspirone, chloral hydrate, diphenhydramine, diphenhydramine, doxylamine, dextromethorphan, eszopiclone, hydroxyzine, meprobamate, zaleplon, zolpidem Antipsychotics aripiprazole, asenapine maleate, chlorpromazine, clozapine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine, haloperidol, iloperidone, loxapine, lurasidone, mesoridazine besylate, molindone, olanzapine, paliperidone, perphenazine, pimozide, promazine, propiomazine, quetiapine fumarate, risperidone, thioridazine, thiothixene, trifluoperazine, triflupromazine, ziprasidone, ziprasidone mesylate Antidepressants amitriptyline, amoxapine, bupropion, citalopram hydrobromide, clomipramine, desipramine, desvenlafaxine, desvenlafaxine fumarate, desvenlafaxine succinate, doxepin, duloxetine, escitalopram oxalate, fluoxetine, fluvoxamine, imipramine, isocarboxazid, levomilnacipran, maprotiline, mirtazapine, nefazodone, nortriptyline, paroxetine, paroxetine, phenelzine, protriptyline, sertraline, tranylcypromine sulfate, trazodone, trazodone, trimipramine maleate, venlafaxine, vilazodone hydrochloride, vortioxetine hydrobromide QT-prolonging ciprofloxacin, clarithromycin, clozapine, dofetilide, medications droperidol, fluoxetine, gatifloxacin, haloperidol, itraconazole, ketoconazole, levofloxacin, risperidone, sumatriptan, zolmitriptan, amiodarone, amitriptyline, amitriptyline, cisapride monohydrate, desipramine, imipramine, imipramine pamoate, moxifloxacin, procainamide, quetiapine fumarate, quinidine sotalol, dolasetron mesylate, doxepin, erythromycin, ibutilide fumarate, methadone, sertraline, thioridazine , venlafaxine, ziprasidone, ziprasidone mesylate, aripiprazole

Downloaded From: https://jamanetwork.com/ on 09/29/2021 References

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