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Ingredients for Pet Nutrition

Product catalogue 2012 DNP Pets_Products_Tabellen-2012_Layout 1 21.03.12 14:37 Seite 3 DNP Pets_Products_Tabellen-2012_Layout 1 21.03.12 14:37 Seite 4

Table of Content

History of DSM 4

Nutritional ingredient production 6

Premixes and blending 8

Nutritional ingredients 10

Formulation 14

Innovation 17

Pet Nutrition Concepts 18

Application 20

Table of Products 22

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History of DSM Re-invention of a successful company 1963 DSM’s first Steam-cracking installation opened.

DSM 1920 1940 Bituminous quality Construction of of coal leads to Central 1902 diversification into Laboratory in DSM founded as fertilizers, utilizing Geleen. Netherlands state the ammonium from owned mining coking gas company “DSM – resulting in De Staats Mijnen”. production of 1950’s Mining activities first ammonia In response to global decline in coal use focus on the based fertilizer. and increasing importance of Limburg region in polymers, DSM focuses on the South of the providing industrial chemicals Netherlands. and raw materials for synthetic fibers and yarns based on oil and natural gas. 1938 1933 Establishment of industrial Commences industrial production of 1950 synthesis of C , B1, based on the Development of the chemical B2, E and K. process of Nobel synthesis of ß-carotene. prize winner Tadeusz Reichstein.

Hoffmann-La Roche

Industrial The world’s Clean antibiotics biocatalysis: strongest fiber: production: In the early 1970’s In the 1990’s DSM In 1996 DSM DSM implemented developed pioneered the first the first industrial Dyneema®,the commercial biocatalytic process. world’s strongest production of semi- Chiral amino acids are produced using fiber. Initially developed for cut resistant synthetic antibiotics based on microbial specific , able to synthesize fabrics and bullet proof vests it is 40 fermentation instead of chemical target enantiomers with exceptional times stronger than steel. Now used in synthesis. Identifying new enzymes and purity. A whole toolbox of enzymes and numerous applications ranging from constructing new biosynthetic pathways chemical catalysts is now available for fishing lines to ropes in offshore by modern genetic technologies allowed producing chiral ingredients for the applications, high performing fabrics or a dramatic decrease in the pharmaceutical industry. reinforced and durable materials for environmental impact of antibiotic vehicles and power plants. Latest focus production. is on the use of Dyneema in invasive medical applications.

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1970’s – 1980’s DSM diversifies into high performing plastics and fine chemicals. 2008 New regional headquarter inaugurated in Shanghai (China). 1975 Dutch Prime Minister officially closed the country's last mine. 1990’s DSM moves into products for the food 1989 and pharmaceutical industries as well as performance materials for DSM shares floated at the Dutch the automotive and stock exchange (today Euronext). electronics sector.

2011 DSM acquires Martek 1996 2005 Biosciences DSM acquires biotech and World’s largest fermentation company Gist- production plant for Brocades, a global leader in opens yeast, yeast extracts, antibiotic in Sisseln production and enzymes, Switzerland. broadening DSM into a life science company. 2011 Rebranding 2006 of One DSM Global premix strategy 2003 initiated to grow the DSM acquires Roche's and Fine global premix network Chemicals Division, forming DSM for high-quality mixes. Nutritional Products, providing the full range of fat-soluble and water-soluble vitamins, carotenoids, long chain polyunsaturated fatty acids, enzymes and nutraceuticals to the feed, pet food, food, pharmaceutical and personal care industry.

High yielding Sustainability Bio-based cell culture through en- performance technology: zymes: materials: Since 2002 DSM, in 40 years experience In 2010 DSM started collaboration with in application to introduce a series Crucell (NL), has has resulted in a of bio-based resins developed a leading technology for large range of enzymes based solutions. for the automotive industry, proven to the production of antibodies applying DSM’s global alliance with Novozymes match the high performance and speed human cell lines. The technology (DK) provides a wide range of feed of traditional chemical products. allows human cells to be cultivated in enzymes which, together with enzyme Palapreg® ECO and EcoPaXX® are high density resulting in an efficient solutions for second generation biofuel composed of more than 50% renewable biosynthesis at high quality. DSM is and biogas processes, makes a resources helping the industry to meet licensing out this technology to its tremendous impact on a sustainable sustainability targets. They are used in customers and acts as development development of global food production. bodyworks, engine compartments and and manufacturing partner. transparent casings for head lamps.

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Nutritional ingredient production Reliability through backward integration

DSM Nutritional Products operates ten bulk manufacturing and formulation sites across Europe, the United States and China. These sites produce the majority of DSM’s nutritional ingredients sold as straight products or in premixes and concentrates.

Quality is at the heart of all our operations, integration concept which gives unrivalled main distribution centres in Venlo (NL), and we work to a global quality standard, control over our supply chain. DSM has a Belvidere (USA) and Singapore. backed by our unique backward dedicated logistics network based on three

Kingstree, USA The Kingstree plant is dedicated to the Dalry, UK production of nutritional Located in Ayrshire, Scotland the lipids by algal and site is involved in the production of fungal fermentation. and related derivatives. It also harbors the production of Panthenol and Ca-Panthothenate.

Freeport, USA Freeport, Texas is the location of a site specialising in the production of ß-carotene and intermediates for other carotenoids. Leon, Spain DSM´s Leon site is dedicated to the production of natural carotenoids, Belvidere, USA such as β-carotene and lycopene. Located adjacent to the Delaware River in New Jersey this is the production site for arachidonic acid and formulations of various vitamins including vitamin E for feed appli- cations. The site also includes a premix facility for food applications. Village Neuf, France Formulations of several vitamins and carotenoids are produced at Village Neuf which is also the production site for STAY-C stable vitamin C forms for feed applications. The site also includes a premix unit for food applications and the DSM Research Center for animal nutrition.

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Grenzach, Germany Located adjacent to the Rhine in Southern Germany, this site primarily focuses on the production water soluble , and vitamin C derivatives. In addition, intermediates used in the production of caretenoids are produced.

Sisseln, Switzerland Sisseln is the production site for several carotenoids and vitamin A. Other operations include the purification and formulation of Ω3 fatty acids, the formulation of several vitamins for various applications and the custom synthesis of pharmaceutical intermediates. Sisseln is also home to our pilot plant and process development center.

Xinghuo, China The Xinghuo site is located close to Shanghai. It is specialised in the formulation of vitamin E for feed applications and also includes a premix production facility for food and feed applications.

Lalden, Switzerland Located high in the Swiss Alps, Lalden is a production facility for intermediates used in the syntheses of vitamin E and A at Sisseln. The site also specialises in the manufacture of aroma intermediates.

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Premixes and blending Product services where customers need them

DSM has a comprehensive global network of premix plants with close to 40 plants dedicated to the production of pet food and feed premixes and another six plants for human food premixes. This network helps ensure high levels of customer service and delivery, backed by the highest levels of traceability, quality and food safety. Being close to our markets allows us to respond quickly to changing customer demands.

USA Belgium

Spain

USA

Mexico Brasil

South Africa

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Europe/EMEA North America Latin America DSM’s comprehensive network of All five North American plants are DSM is represented in most Latin premix plants in Europe comprises medication-free with one facility American countries with appropriate 12 plants, each of which operates having advanced capabilities for the pet food production with a total of 11 specific clean lines. In Belgium production of blends for pet food plants. The design of most plants additionally a fully separated and production. These facilities assure allow the operation of clean lines dedicated plant for the production customers of outstanding experience while the plant in Chile is operated as of pet food premixes is located. in the supply of pet food premixes. clean, mediation-free plant.

China DSM has production capabilities in all the major pet food producing and China exporting countries in the region. In Thailand a clean plant is operated while all other locations include clean Russia lines. Recently the premix network was expanded in India.

Asia Pacific DSM is expanding its premix network in China and today serves most areas of the country from five sites, all operating a clean line. Advanced segregation control is implemented in the newest plant meeting latest requirements of the pet industry.

Korea

Thailand

Australia

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Nutritional ingredients A brief guide to vitamins

DSM produces an extensive portfolio of nutritional ingredients for use in pet food products and supplements including minerals, vitamins, carotenoids, nutraceuticals and long chain polyunsaturated fatty acids. These products deliver a wide range of health benefits to all pet species. Vital for the efficiency of a broad array of functions in the body, the DSM vitamin range contains all the vitamins crucial for healthy, thriving, long-living pets.

Vitamin A Vitamin D Vitamin E Necessary for vision, growth, and Helps the body maintain and utilize Helps protect cell membranes. tissue differentiation. Is important the levels of calcium and Helps maintain the immune system, for keeping the skin, eyes, and phosphorus needed to build strong prolong the life of red blood cells, inner linings of the body healthy bones and teeth. Recent studies maintain a healthy circulatory and resistant to infection. Vitamin A have shown additional benefits system, and improve vitamin A use. is also needed for the maintenance such as supporting immune health, Important for the health and proper and growth of teeth, nails, hair, weight management, and cancer functioning of body tissues. An bones and glands. prevention. antioxidant, neutralizing free radicals.

Vitamin K Vitamin B1, Vitamin B2, Essential for the clotting of blood Helps the body use its major source Helps the body transform proteins, and may help maintain bone of energy, carbohydrates. Thiamine fats, and carbohydrates into health. is also essential for proper muscle energy. Helps maintain healthy skin coordination, the maintenance of and eyes and is also necessary for peripheral nerve tissue, and for building and maintaining body normal growth. tissues.

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Vitamin H, Necessary for synthesizing fatty acids and breaking down protein and carbohydrate molecules. Helps in the maintenance of the thyroid and adrenal glands, nervous system, reproductive tracts, and skin.

Vitamin B3, Vitamin B5, , Niacin and niacinamide are Necessary for energy metabolism, essential for fat synthesis, protein the formation of certain proteins, Essential for the formation of metabolism, and the conversion of and the use of amino acids. certain nerve-regulating substances food to energy. It also helps the nervous system to and hormones. It is also required function properly and is essential to for metabolism of proteins, fats, a healthy immune system. B6 is and carbohydrates. essential to heart health.

Vitamin B9, Folic Acid , Vitamin C, Ascorbic Acid Required for the formation of red Cyanocobalamine Aids the production of collagen, which provides support to muscles, blood cells, certain body proteins, Necessary for the formation of DNA vascular tissues, bones, and cartilage. and genetic materials for the cell and the production of healthy red Aids the absorption of iron and nucleus. Emerging science blood cells. Helps maintain the suggests it may play an important improves teeth and gum health. Is nervous system and is essential to an important water soluble antioxidant. role in reducing risk of maintaining mental function. Enhances the immune response cardiovascular disease, dementia, Vitamin B12, along with B6 and and plays a protective role against and certain cancers. , is essential to heart health. cardiovascular disease, cataracts, and certain cancers.

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Nutritional ingredients Delivering healthier pets

DSM’s portfolio of nutritional ingredients includes a broad range of carotenoids used as antioxidants, functional ingredients or colorants. Additionaly nutraceuticals developed for the human food market are made available to the pet food industry.

Carotenoids

β-Carotene Zeaxanthin (Optisharp™) Lycopene (redivivo™) β-carotene is an important source and Lutein Lycopene is the carotenoid of vitamin A, converted Zeaxanthin and Lutein are the responsible for the red color in into vitamin A as required. carotenoids found in the retina and tomatoes. It has been associated The additional health-promoting lutein in the tissue of the lens. They with a healthy prostate, lung, effects of β-carotene include act as antioxidants and absorb stomach, and cardiovascular antioxidant functionality protecting near-to-UV blue light. Higher function. cells, tissues, and organs from free dietary intake of foods rich in lutein radical damage and as a contributor and zeaxanthin has been to the robustness of the pet’s associated with a reduced risk immune system. retinal degeneration and cataracts.

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Minerals and Nutritional lipids Nutraceuticals trace elements Coenzyme Q10 (All-Q™) Coenzyme Q10 (CoQ10) is an antioxidant Selenium (Se) involved in energy metabolism in all Selenium is an antioxidant and helps cells. Cells that benefit the most from protect cell membranes, especially those CoQ10 are those that have a more rapid of the muscle cells. turnover, including heart, gingiva, Iodine (I) mucosal cells of the intestine, and immune system cells. Iodine is an essential nutrient for the proper functioning of the thyroid gland. Protein hydrolysate (PeptoPro®) Copper (Cu) PeptoPro® is a casein hydrolysate, a source of amino acids in the form of di- Copper is an anti-anemic factor and is a Omega-3 from algae vital trace element. It facilitates the peptides and tripeptides, that does not Dried DHA omega-3 derived by algal intestinal absorption of iron and is an need further digestion in the body and fermentation, specifically suitable active part in enzymes promoting can be delivered straight to the muscles. for pet nutrition products. ® cellular oxidation. It is essential in the Human trials have shown PeptoPro synthesis of collagen in the cells of the improves endurance and performance, nervous system. stimulates muscle growth, accelerates recovery and reduces muscle soreness. Manganese (Mn) Manganese contributes to the quality of Epigallocatechin gallate, ™ the bones and cartilage and must be EGCG (TEAVIGO ) especially monitored in growing animals, EGCG is the most abundant catechin as well as aging animals suffering from found in green tea, and has been osteoarthritis. Plays an active role in the associated with reducing the risk of functioning of the mitochondria and is various chronic diseases such as cancer important in the formation of bone and and cardio vascular diseases. Animal joint cartilages. model studies suggest that green tea rich in EGCG and pure EGCG decreases Zinc (Zn) fat absorption and increases fat burning Zinc is a crucial trace element for Omega-3 from fish to reduce body fat. collagen and keratin synthesis. It is a Contain eicosapentaenoic acid (EPA) ™ coenzyme in many metabolic systems. Resveratrol (resVida ) and/or docosahexaenoic acid (DHA) It is essential to the transport of vitamin Resveratrol has anti-oxidant activity and which are associated with A in the blood and plays an important is best known as the component in red cardiovascular health, eye health, role in reproduction. Zinc is also a wine that may confer heart health brain health (including improved fundamental element for skin integrity benefits in the French population despite puppy trainability), limit excessive and coat quality. It helps the their high fat intake, i.e. the French inflammatory reactions and support elimination of lactates produced Paradox. Recent studies demonstrate joint, skin, and coat health. during short, intense muscle effort. resveratrol mimics the effect of caloric restriction, the only known intervention to extend lifespan in mammals. It also has been shown to preserve the health of aging mice through maintenance of cardiac function, muscle function, and blood sugar control.

Fabuless™ vegetable oil emulsion Fabuless™ is a patent-protected combination of vegetable oils that is formulated in an emulsion. It avoids early Omega-6 digestion and triggers an “appetite Rich source of γ-linolenic acid (GLA) satisfied” signal to the brain, helping to or arachidonic acid (ARA) being manage calorie intake. Fabuless can be helpful in modulating inflammation incorporated in food products or and the restoration of the natural marketed as a weight management barrier of the skin. supplement.

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Formulation Effective products for food, pet food and feed applications

The pet food sector is becoming increasingly sophisticated with the demand for a wide range of ingredients with different matrices, textures, colours, shapes and nutritional functionality as suppliers look to differentiate their products on the retailers' shelves.

External factors influencing vitamin stability

VITAMIN Temperature Oxygen Humidity Light pH Acid pH Alkaline

Vitamin A XX XX X XX X 0

Vitamin D3 X XX X X 0 X Vitamin E - Acetate 0 X 0 0 0 X

Vitamin K3 XXX X XX X XX XX Vitamin B1 XXX00X X X 0 0 XX Vitamin B2 000 0 XX0XX X 0 X Vitamin B6 XX 0X0000 X 0 0 0 Vitamin B12 XX XXX00X X X 0 0 Pantothenic acid X0X0XXX 0 X 0 X X Nicotinic acid 0000000 0 0 0 0 0 Biotin X00000X 0 0 0 0 0 Folic acid XX 0X0 X XX XX 0 Vitamin C XX XX XX X0XX 0 X

0 = Stable X=Sligthly sensitive to sensitive XX=Very sensitive

Product form requirements mall particle size Heat stable Moisture stable Shear tolerant Resistant to oxidation Not adversely effected by enzyme activity Low coloration and/or s Compression tolerant Resistance to UV light Proper solubility or miscibility

Extrusion ••• • Baking ••••• Retorting / Steaming •••••• Fresh / Frozen •••• Injection molding ••••• Dry mixing / Powder •••• Tableting / Compression ••••• High fat liquid • • • • • • • • Low fat liquid / Milk • • • • • • • • Clear water • • • • • • •

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Form requirements Certain basic characteristics are required if the ingredient form is to achieve the envisioned nutritional value of the pet food product: Bioavailability: The nutrient should have a chemical structure which is fully metabolized and the product formulation should provide protection but release the nutrient upon ingestion. Stability: The ingredient must remain stable “as is” or in blends and premixes. Therefore the ingredient must be adequately stabilized in a chemical and/or product form which when stored, transported, milled, or mixed, maintains its activity. The product form must be resistant to activity loss due to environmental factors such as temperature, moisture, and oxygen. Uniformity: The particle size and size distribution determines how well the nutrient is dispersed throughout the finished product, impacting the nutrient activity per serving. A uniform product minimizes the tendency for nutrients to segregate when mixed and transported with other micro-ingredients, allows adequate flow through equipment during production and reduces dust formation when handled. Consistency in potency: For reliable dosing of a nutrient in production, potency must be consistent both particle-to-particle and lot-to-lot. Production of ingredient forms The availability of appropriate dilutions supports the accuracy of dosing during Production: Functional ingredients such as vitamins or carotenoids are produced production. either by chemical synthesis, by fermentation, by extraction (often from a natural source) or by a combination of these technologies. Dissolution behaviour: Modification: Once the basic functional compound is produced it may be further The form of the nutrient dictates its processed to develop a more stable chemical form, using processes such as aqueous (water) or non-aqueous (fats or oils) solubility or miscibility. These crystallisation of an organic salt, esterification and phosphorylation. physical characteristics influence the Formulation: To achieve specific product characteristics the ingredients then distribution of the functional ingredient in undergo a formulation process. Such formulation creates highly specified nutrient the final pet product, its colour, texture forms optimally equipped to meet the specifications within a pet food, food or feed and/or shelf life. product.

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Formulation technologies

Crystalline grades Nutrient compounds are chemically modified to form organic salt which after drying are not further formulated but used “as is”. Optionally crystalline material can be coated with ethyl cellulose which slows any possible detrimental influence of other ingredients present in the formula.

Vitamin in crystalline form

Adsorbates Suitable carriers such as silica particles are prepared for absorbing mainly fat Silicic acid soluble nutrients. Adsorption has the advantage of delivering an economically attractive dry form of an intrinsically stable nutrient, and results in a free-flowing powder with good mixability, flowability and dust characteristics.

Vitamin adsorbed on silicic acid

Matrix (lignosulfonate) Spray-dried powders Spray-drying is applied for many of the water soluble nutrients to enhance Silicic acid stability, handling and distribution. The nutrient compound is added into a dextrin (silica flow aide) solution. The solution is spray dried into a powder, which offers a variety of advantages including stabilizing the nutrients and delivering it in a digestible matrix. Vitamin droplets

Matrix (gelatine/carbohydrates or vegetable) Beadlets In beadlet technology nutrient compounds are emulsified in a gelatine, starch and Maize starch glycerine matrix, with an antioxidant sometimes added to increase stability. The emulsion is then sprayed to form beadlets which are coated with corn starch to absorb excess moisture. Moist beadlets are dried to produce the finished beadlet. Micronization of the often oily functional ingredient allows the production of stable, Carotenoid yet dispersable beadlets for clear liquids. emulsified with antioxidants

Matrix (gelatine, glycerine and carbohydrates)

Cross-linked Beadlet Calcium silicate/ Additional chemical bonds are introduced to create a hardened Maize starch beadlet most commonly referred to as a cross-linked beadlet. A chemical reaction occurs which creates cross-linked bonds thereby creating a more rigid structure. This technology provides Vitamin/ excellent stability and is used to protect nutrients in high Carotenoid temperature applications. emulsified Cross-linked gelatine with antioxidants

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In n New ingredients for pet nutrition

At DSM, our aim is to provide innovative nutritional solutions to meet current and future nutritional requirements and health concerns. Our R&D centers specialize in the development of nutritional ingredients and related applications. Close customer integration is provided through our regional food application laboratories while our involvement in the human food sector allows us to leverage knowledge which can be beneficial for pet food developments.

Nutritional concepts In a rapidly developing market place, it is important that new opportunities are fast tracked to meet demand from customers. Our novel nutritional concepts approach ensures this happens while fostering customer involvement in our innovation and targeting R&D investment.

Market Customer Ingredient trends needs portfolio

Literature Animal Trials In-house data Concept Stability Development Product forms Patents Applications

Nutritional concepts

Building meaningful customer relationships Our customers are the reason we exist and our goal is to work closely with them throughout all stages of the innovation process from ingredient development through to new product development and product re-launches. We value customer feedback and strive to incorporate their views on areas such as premix and product formulation, product marketing and brand characteristics.

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Pet Nutrition C epts Supplying solutions for health concerns

Effective pet nutrition is about preserving the health and vitality of companion animals and this means providing a tailored package to meet specific needs.

With our unrivalled track record in animal nutrition and health, backed by our broad ingredient base DSM is the leader in pet nutrition concepts. We are at the forefront of the development of new ingredients, often drawing from our expertise in human nutrition to create innovative solutions.

Working in close collaboration with our customers we can tailor nutritional concepts to help develop differentiated products which deliver effective solutions to the needs of customers, pet owners and pets.

Defying age Nourishing the coat Nutritional support for Nutrition for skin and fur longevity

Shaping the body Freshening breath Weight management and Oral care based on Vitamin C calorie control

Protecting the paws Encouraging attention Resistance to outdoor Cognitive performance through challenges all life stages

Safeguarding vision Enhancing mobility Proactive nutrition for Nutrition for healthy joints maintaining eye heath and strong bones

Stimulating the defence Living an active life Stronger immune support for Pet companionship at its best every day’s challenges

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Applications for pet nutriti A variety of technologies for shape, size, texture, moisture and form

The pet food market is characterized by a wide variety of different product forms. This occurred because ingredient forms were developed to support changes in formulation, process conditions, and packaging. Specially formulated nutritive and functional ingredients are often the key to the successful development of foods, treats, and supplement products. As a leader in nutritional ingredient form development, DSM offers a comprehensive range of ingredients suitable for the full range of manufacturing processes and formulation options our customers use to create products with distinct points of differentiation.

Extruded products Baked products Extrusion, one of the harshest processing technologies, is used to produce food and treat Food, treat, and flaked products are products. This process typically requires ingredients to be exposed to high temperatures, manufactured using baking. Initially, pressure, moisture, sheer, rapid expansion, and a drying step. dough is formed exposing the ingredients to moisture and sometimes For this application, nutritive ingredients need to be resistant to rapid changes in enzymes. The formed dough is heated to temperature, pressure and moisture heat, sheer, and oxidation throughout manufacturing the desired degree of cook and dryness. plus remain shelf stable for 18-24 months. For this application, nutritive ingredients need to be resistant to heat, moisture, enzymes, and oxidation throughout manufacturing plus remain shelf stable for 18-24 months.

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Wet products Injection molding Dry mixes and powders Wet food styles include loaf (pate) and This process is used to manufacture Dry mixture products range from chunk-in gravy foods and treats. treats and chews where appearance, supplements to milk replacers. Dry Initially, meat and other ingredients are structure and actual product design are blends require ingredients that can be mixed with or without heat for various major challenges. This process usually dispersed readily throughout the periods of time. This mixture is either involves high temperatures with a low mixture, not prone to particle segre- placed in a container, sealed and cooked sheer and moisture. gation/separation and are chemically at a high temperature or cooked using a For this application, nutritive ingredients stable. Some are designed to be added need to be resistant to high and to liquids and must be readily soluble or changing temperatures, and oxidation. miscible. The finished product color and hardness For this application, nutritive ingredients must not be adversely affected and usually need to be uniform in particle remain shelf stable for 24 months. size and density, chemically and heat stable, have a low propensity to create an electrostatic charge, not attract steam tunnel, formed into chunks, moisture plus resist oxidation through sealed in a container with gravy, and manufacturing and storage. The finished cooked again at a high temperature. product color must also not be adversely For this application, nutritive ingredients affected. need to be resistant to moisture, oxi- dation, enzymes, and extreme changes in temperature throughout manufac- turing. Finally the finished product color must not be adversely affected plus Milk and fatty liquids remain shelf stable for 24 months. High fat(oil) paste and liquid products range from infant food to lubricants for Compressed tablets the gastro-intestinal tract to aid mobility Clear solutions and control hairballs. During manufac- Bottled waters are sometimes used to Tablets are swallowed, chewed or turing these types of fatty liquids often deliver functional ingredients. Unlike dissolved to deliver their functional experience high shear during mixing and other liquid products, formulating while ingredients. During manufacturing the homogenisation, high temperatures maintaining clarity is the challenge. ingredients may be ground and screened during sterilization, and unwanted to obtain a uniform particle size. The final enzyme activity. In addition to the attributes associated blend experiences pressure and sheer with manufactured liquid products, while forming the tablets. Depending on nutritive ingredients for this application the packaging, the tablets may be ex- must not react to other ingredients, UV posed to moisture and oxygen. light or oxidation causing a loss of Some tablets are formulated to effervesce nutritive value, colouration or when added to water subsequently ex- sedimentation. posing the ingredients to moisture, changes in pH, and further oxidation for an undefined period of time. For this application, nutritive ingredients need to be resistant to pressure, shear, oxidation, and possibly reduction in For this application, nutritive ingredients particle size, changes in pH and moisture. may need to be resistant to UV light, oxidation, sheer, high and rapidly changing temperatures, enzyme activity, display high miscibility and emulsification properties during manufacturing plus remain shelf stable for 3 to 24 months without causing sedimentation or other negative product attributes.

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Table of Products

Carotenoids ␤-Carotene 24 Canthaxantin Astaxanthin Lutein 25 Lycopene Zeaxanthin

Fat soluble Vitamins Vitamin A 26 Vitamin D3 Vitamin E 27 Vitamin K3,

Water soluble Vitamins Vitamin B1, Thiamine 28 Vitamin B2, Riboflavin Vitamin B3, Niacin Vitamin B5, Pantothenate 29 Vitamin B6, Pyridoxine Vitamin B9, Folic acid Vitamin B12, Cobalamin Vitamin H, Biotin VitaminC,Ascorbicacid

Nutritional lipids Omega-3 Fatty Acids from algae 31 Omega-3 fatty acids from fish Omega-6 fatty acids

Nutraceuticals Coenzyme Q10 32 Protein Hydrolysate EGCG, Green Tea extract Resveratrol Fabuless

Minerals Mineral Preparations 34 Mineral Chelates

Ingredient forms: Application: : Feed ingredient Dry: Dry pet food and treats : Food ingredient Wet: Wet pet food and treats Inject.: Injection molded chews Sales region: Tabl.: Tablet supplements EUR: Europe, Middle, East & Africa Pow.: Powder supplements NA: North America Milk: Milk and low fat liquid products LA: Latin America Water: Water based liquid products APA: Asia Pacific, Australia CN: China

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Carotenoids

β-CAROTENE Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX® β-Carotene 10% stabilized beadlet 5, 20 04 43077 France

ROVIMIX β-Carotene 10% P cross-linked beadlet 20 50 02761 France

β-Carotene 10% CWS beadlet, cold water dispersible 1, 5, 20 50 10152 Switzerland

β-Carotene 10% CWS/S beadlet, cold water dispersible 5, 25 04 89999 Switzerland

β-Carotene 10% B cross-linked beadlet 5, 25 04 34833 Switzerland

BetaTab® 20% S beadlet, tablet grade 5, 25 50 04004 Switzerland

CaroCare® Nat. beadlet, cold water dispersible 25 50 04713 Ireland β-Carotene 1% CWS

Betanat® 30% OS oily suspension 20 5014015 Spain

Betanat® 10% CWD beadlet, cold water dispersible 10 5014005 Spain

Canthaxantin Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Dry Wet Inject. Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Carophyll® Red 10% (Canthaxanthin) beadlet 5, 20 50 02885 France

Canthaxanthin 10% CWS/S beadlet, cold water dispersible 5, 25 50 05256 France

Astaxanthin Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Carophyll Pink 10% CWS (Astaxanthin) beadlet, cold water dispersible 5, 20 50 01080 France

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Lutein Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Lutein 20 % FS fluid suspension 5, 20 50 00742 France

Lutein 5% CWS/S-TG beadlet, tablet grade, 5, 25 50 05213 Switzerland cold water dispersible

Lycopene Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Dry Wet Inject. Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Redivivo® 10% FS (Lycopene) fluid suspension 5, 20 50 00203 France

Redivivo 10% CWS/S-TG (Lycopene) beadlet, tablet grade, 5, 25 50 03792 Switzerland cold water dispersible

Lycomat® Lycopene 10% OS oily suspension 5 50 14025 Spain

Lyconat® Lycopene 10% CWD beadlet, cold water dispersible 5 50 14020 Spain

Zeaxanthin Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

OPTISHARP® 20% FS (Zeaxanthin) fluid suspension 5, 25 50 02001 France

OPTISHARP 5% CWS/S-TG beadlet, tablet grade, 5, 20 50 03563 Switzerland (Zeaxanthin) cold water dispersible

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Fat soluble Vitamins

VITAMIN A Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX A 1000 (1000 kIU/g) cross-linked beadlet 20, 500 50 12805 Switzerland

ROVIMIX AD3 1000/200 cross-linked beadlet 20, 500 50 12813 Switzerland (1000 kIU A/g) (200 kIU D3/g)

ROVIMIX A-500 WS (500 kIU/g) spray-dried, water dispersible 20 50 02486 France powder

Vitamin A Palmitate 1.0 mIU/g oily solution, stabilized 5 50 08530 Switzerland with

Vitamin A Palmitate 1.7 mIU/g stabilized with tocopherol 5 04 18579 Switzerland

Dry Vitamin A Acetate 500 (500 kIU/g) beadlet, tablet grade 5, 25 04 83818 USA

Dry Vitamin Acetate + D3 500/50 beadlet, tablet grade 5 04 83826 USA (500 kIU A/g, 50 kIU D3/g)

Dry Vitamin A Palmitate, spray dried, starch based 20 50 00718 Switzerland Type 250 S/N (250 kIU/g)

VITAMIN D 3 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Dry Wet Inject. Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX D3 500 (500 kIU/g) spray-dried, water dispersible, 20 04 40140 France stabilized powder

ROVIMIX AD3 1000/200 cross-linked beadlet 20, 500 04 89735 Switzerland (1000 kIU A/g) (200 kIU D3/g)

Vitamin D3 1.0 mIU/g oily solution, stabilized 5 50 11574 Switzerland with tocopherol

Dry Vitamin D3 100 SD/S spray dried, cold water 5, 20, 50 50 10950 Switzerland (100 kIU D3/g) dispersible, stabilized with tocopherol

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VITAMIN E Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Tocopheryl Acetate Technical Grade clear viscous oil 190 04 25621 Switzerland (100% Basis)

ROVIMIX E 50% Ads (500 IU/g) oil adsorbate 25, 900 04 34604 Switzerland on silicic acid 25, 700, 900 50 08808 USA 25, 500 50 08816 China

ROVIMIX E 50% SD (500 IU/gm) spray-dried, powder 20, 600 50 02575 France water dispersible

Dry Vitamin E 15% CC spray-dried, powder, 15 50 01285 Switzerland starch based, crystal clear

Dry Vitamin E 50% CWS/S spray-dried, powder, 20 50 01129 Switzerland cold water dispersible

Dry Vitamin E 50%, Type SD spray-dried, powder 50 04 39622 Switzerland

Dry Vitamin E 75 HP beadlet, high potency 20 04 83567 USA

d,l-␣-Tocopherol liquid antioxidant 5, 20, 50 04 10276 Switzerland

Mixed 95 liquid antioxidant, 20, 190 50 02893 USA natural source

Dry Mixed Tocopherol 30% dry antioxidant, natural source 20 50 00149 USA

VITAMIN K, MENADIONE Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

MSBC fine crystalline powder 25 04 37271 Turkey (Sodium bisulfite complex, 33%)

K3 Stab (MNB, 43.7% menadione) fine crystalline powder 25 04 30498 Italy

Rovimix K3 MNB fine crystalline powder 25 50 09197 Italy 50 09014 Uruguay 50 06155 China

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Water soluble Vitamins

VITAMIN B , THIAMINE 1 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX B1 (Thiamine Mononitrate) fine crystalline powder 25 04 21863 Germany

Thiamine HCl fine crystalline powder 20 04 13038 Germany (Thiamine Hydrochloride)

Thiamine Mononitrate powder 20 04 18943 Germany

ROCOAT® Thiamine Mononitrate 33% coated powder 5 04 29473 USA

VITAMIN B , RIBOFLAVIN 2 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX B2 80 SD spray-dried, powder 20 04 70392 Germany water dispersible

Riboflavin tablet Grade 10 04 70295 Germany

Riboflavin Universal powder 10 04 70406 Germany

ROCOAT Riboflavin 33% coated powder 5 04 29465 USA

VITAMIN B , NIACIN 3 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX Niacin fine crystalline powder 25, 900 04 10160 Switzerland

ROVIMIX Niacinamide fine crystalline powder 25, 500, 1000 50 08654 Belgium

Niacinamide FG fine crystalline powder 25 04 30528 USA

Niacin powder 20, 50 04 10837 Switzerland

ROCOAT Niacinamide 33% coated powder 5 04 29449 USA

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VITAMIN B , PANTOTHENATE 5 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX CalPan spray-dried, powder 25 04 42305 Great Britain (Calcium Pantothenate) water dispersible

Calcium D-Pantothenate spray-dried powder 25 04 12678 Great Britain

VITAMIN B , PYRIDOXINE 6 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX B6 fine crystalline powder 25 04 23831 Germany

Pyridoxine Hydrochloride crystaline powder 20 04 11604 Germany

Pyridoxine Hydrochloride 98% DC direct compression powder 20 04 11663 Switzerland

ROCOAT Pyridoxine coated powder 5 04 29457 USA Hydrochoride 33%

VITAMIN B , FOLIC ACID 9 Sales region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code origin Tabl. Pow. Milk Water

ROVIMIX Folic 80 SD spray-dried, powder, 20 04 17831 France water dispersible

Folic Acid powder 1, 25 04 18723 Switzerland

FolicAcid10% triturate, powder 10, 50 468363 USA

VITAMIN B , COBALAMIN 12 Sales region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code origin Tabl. Pow. Milk Water

Vitamin B12 1% crystalline powder dilution 25 04 42291 France

Vitamin B12 Crystalline crystalline powder 0.01, 0.1, 1 04 29155 France

Vitamin B12 0.1% Type SD spray-dried 50 04 10136 USA

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VITAMIN H, BIOTIN Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX Biotin 2% spray-dried powder, water dispersible 20 50 04284 France

ROVIMIX Biotin HP 10% spray-dried powder, water dispersible 20 50 05582 France

D-Biotin white cystaline powder 0.05, 1 04 17459 France

Bitrit-1 Type A 1% (D-Biotin) triturate, powder 10, 50 50 06244 USA

VITAMIN C, ASCORBIC ACID Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Dry Wet Inject. Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROVIMIX Stay-C® 35% spray-dried powder, heat stable 25, 800 04 83044 France (L-ascorbyl-2-phosphate)

ROVIMIX C-EC ethylcellulose coated powder 25 04 82978 Great Britain

ROVIMIX Stay-C 50% spray-dried fine powder, heat stable 5, 20 50 00858 France (L-ascorbyl-2-phosphate)

Ascorbic Acid crystaline powder 25 04 08050 Great Britain

Ascorbic Acid Fine Powder fine powder 25 04 22460 Great Britain

Ascorbic Acid Fine Granulation granular 25 04 08093 Great Britain

Ascorbic Acid 95% Granulation granular 25 56 07747 Great Britain

Calcium Ascorbate powder 25 04 19443 USA

Ascorbyl Palmitate powder 5, 25 04 18595 Germany

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Nutritional Lipids

OMEGA-3 FATTY ACIDS FROM ALGAE Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

DHAgold S17-B Dried flakes from algae 15 50 13771 USA Min. 17% DHA 15 50 13798 USA

DHA Powder KSF35 powder, derived from algae 12.5 50 13836 USA Min. 10% DHA

DHA Powder KSF58 powder, derived from algae 12.5 50 13712 USA Min. 20% DHA

DHA-S Food Oil oil, derived from algae 1, 5, 23, 50 13755 USA Min. 35% DHA 180

OMEGA-3 FATTY ACIDS FROM FISH Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ROPUFA® ‘75’ n-3 EE n-3 refined marine fish oil 5, 20, 190 50 08441 Switzerland Min. 75% total n-3 PUFA in form of 5, 190 50 11671 Switzerland ethyl esters, Min. 43% EPA + 22% DHA

ROPUFA ‘30’ n-3 INF Oil n-3 refined marine fish oil 25 50 09537 Switzerland Min. 30% total n-3 PUFA, Min. 23% DHA, DHA:EPA min. 4.5

ROPUFA ‘10’ n-3 INF powder S/SD spray-dried powder, 2,5 50 06392 Switzerland Min.7%totaln-3PUFA n-3 refined marine fish oil

OMEGA-6 FATTY ACIDS Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

Vevodar® clear yellowish oil 1, 10 50 12872 USA Min. 35% Arachidonic acid (ARA)

ROPUFA ‘10’ n-6 Oil n-6 refined evening primrose oil 25 04 22398 Germany Min. 9% g-linolenic acid (GLA)

ROPUFA ‘25’ n-6 Oil n-6 refined borage and 5, 25 50 09596 Germany Min. 23% ␥-linolenic acid (GLA) starflower oil

ROPUFA ‘10’ n-6 Powder encapsulated powder, 2,5 04 28981 Switzerland Min. 9% ␥-linolenic acid (GLA) n-6 refined borage oil

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Nutraceuticals

COENZYME Q10 Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

ALL-Q® 10% CWS/S (Coenzyme Q10) beadlet, cold water dispersible 5, 25 50 04160 Switzerland

ALL-Q 10% TG/P (Coenzyme Q10) beadlet, tablet grade 5, 25 50 03040 Switzerland

PROTEIN HYDROLYSATE Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

PeptoPro® (Hydrolysed casein) crystalline powder 15 50 07143 Germany

EGCG, GREEN TEA EXTRACT Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

TEAVIGO™ (90% EGCG from crystalline powder 1 50 09227 Germany natural green tea extract)

RESVERATROL Sales Region Application Product Product Package Product Country of EUR NA LA APA CN Dry Wet Inject. Name Description Size (KG) Code origin Ingredients for Pet NutritionTabl. Pow. Milk 15 Water

resVida™ (99% trans-resveratrol) crystalline powder 1, 5 50 11108 Switzerland

resVida TG (90% trans-resveratrol) powder tablet grade 1, 5 50 11647 Switzerland

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FUNCTIONAL EMULSIONS Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

FabulessTM 28 – natural taste liquid emulsion 7.5 ml cups 51 12100 Sweden (28% functional lipid emulsion of palm oil, oat oil and water)

Fabuless 42 liquid emulsion 15 50 10896 Sweden (42% functional lipid emulsion of palm oil, oat oil and water)

Fabuless DE fine powder, dry emulsion 15 50 14000 Germany (33% functional lipids from palm and oat oil)

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Minerals

MINERAL PREPARATIONS Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

MicrogranTM Co 5%, BMP free-flowing, micro granules 25, 500 50 01684 Italy (Preparation of cobalt carbonate)

Microgran Se 1%, BMP free-flowing, micro granules 25, 500 50 01668 Italy (Preparation of sodium selenite)

Microgran Se 4.5%, BMP free-flowing, micro granules 25, 500 50 01676 Italy (Preparation of sodium selenite)

Microgran I 10%, BMP free-flowing, micro granules 25, 500 50 01692 Italy (Preparation of calcium iodate)

MINERAL CHELATES Sales Region Application

Product Product Package Product Country of EUR NA LA APA CN Inject. Dry Wet Name Description Size (KG) Code Origin Tabl. Pow. Milk Water

VevominTM Cu 13% free-flowing powder 25 50 06430 Canada (Cupric chelate of amino acids, hydrate)

Vevomin Fe 13% free-flowing powder 25 50 06449 Canada (Ferrous chelate of amino acids, hydrate)

VevominMn11% free-flowing powder 25 50 06422 Canada (Manganese chelate of amino acids, hydrate)

Vevomin Zn 13% free-flowing powder 25 50 06414 Canada (Zinc chelate of amino acids, hydrate)

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Notices DNP Pets_Products_Tabellen-2012_Layout 1 21.03.12 14:37 Seite 1

DSM Nutritional Products

For further information, please visit: www.dsmnutritionalproducts.com or contact:

Headquarters North America DSM Nutritional Products AG DSM Nutritional Products P.O. Box 2676 45 Waterview Boulevard 4002 Basel Parsippany, NJ 07054-1298 Switzerland United States Tel. + 973 257 8504 Fax + 973-257-8650 E-mail: [email protected] Europe, Middle East & Africa Latin America DSM Nutritional Products Europe AG DSM Nutritional Products Latin America P.O. Box 2676 Av. Eng. Billings, 1729-Prédio 9 CH-4002 Basel 05321-900 São Paulo - SP Switzerland Brasil Tel. +41 61 815 7777 Tel.+551137194601 Fax: +41 61 815 7770 Fax + 55 11 3766 4684 E-mail: [email protected] E-mail: [email protected] Asia Pacific China DSM Nutritional Products Asia Pacific Pte Ltd DSM (China) Limited 2 Havelock Road #04-01 No.476,LiBingRoad Singapore 059763 Zhangjiang High-Tech Park Singapore Pudong Area, Shanghai 201203 Tel. +65 6325 6200 China Fax:+65 6220 1976 Tel.+862133104988 E-mail: [email protected] Fax + 86 21 6352 5511 E-mail: [email protected]

Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. The information provided herein is for informational purposes and is intended for business to business use only. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, either expressly or implied. In no event shall DSM be liable for any damages arising from the reader's reliance upon, or use of, these materials. The reader shall be solely responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contact your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlands and/or other countries.

® ® ® ® ® TM ® ® ® ® ® ® ® ROVIMIX , BetaTab , CaroCare , Carophyll Red , Carophyll Pink , DHAgold , Redivivo , Optisharp , ROCOAT ,STAY-C , ROPUFA , Vevodar , ALL-Q , and PeptoPro® are registered trademarks of DSM NV. TEAVIGOTM, ResVidaTM, FabulessTM, MicrogranTM and VevominTM are trademarks of DSM NV.

© DSM Nutritional Products Ltd 2012

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