How Can Pipeline Pilot Help You? Data Pipelining for Pharmacokinetic-Pharmacodynamic Modelling PKPD Modelling Solutions

• Help the modeller by giving access to data from different sources allowing – Integration of Data & Applications – In-depth Analysis • Capture & deploy best-practice processes – Data Sharing & Search Queries – Reporting – Process Automation

© 2008 Accelrys, Inc. 2 Typical PKPD Modelling Workflow

1. Data Handling

2. 6. Decision Exploratory Analysis

3. Model 5. Simulation Building

4. Diagnostic & Qualification

© 2008 Accelrys, Inc. 3 Typical Workflow in Pipeline Pilot

1 Data Handling 6 2

5 3 – From/To multiple disparate sources, Databases or Files 4 – In-House format checking rules, Logging & Archiving Exploratory Analysis, Diagnostics & Decision Tool 1 6 2 – Advanced Reporting capabilities, Interactive Forms, Charts 5 3 4 – Output formats: HTML, PDF, PowerPoint, Word, Excel, etc. – Portlets integration, JavaScript, AJAX, Flash, etc.

1 Model Building & Simulation 6 2 – Application Integration: NONMEM, WinBUGS, Monolix, etc. 5 3 4 – Job Scheduler

1 Plus 6 2

5 3 – Highly Flexible Visual Programming Language 4 – Integrates , SAS, M ATLAB , , Java, VBScript, etc.

© 2008 Accelrys, Inc. 4 Data Integration

1 6 2 • Databases

5 3 4

• Stored in Files • Generated on the fly

• Other Data Type

© 2008 Accelrys, Inc. 5 Log & Archive

1 6 2 • Data Analysis 5 3 • Interactive Report 4

• Databases • Reports • Archives • Flat Files

© 2008 Accelrys, Inc. 6 Visualisation & Reporting

1 6 2 3 2 5 3 4

2 3. File Viewer 1

1. Job Explorer • Run Summary • Sortable Table Select a Run 2 4 4

4 2 4

2. Model Report • Parameter Estimate 4. Patient Report • Goodness of Fit • Individual Plot • Individual Plot • Goodness of Fit Select a File • Patient Data Table Select a Patient Select a Patient © 2008 Accelrys, Inc. 7 Application Integration

1 1 6 2 Modelling & 6 2 Plus 5 3 5 3 4 Simulation 4 • Command Line • NONMEM • ORACLE • WinBUGS • R • Monolix • MATLAB • Xpose • SAS • WinNonLin • Perl • PsN • Java • simCYP • Python • MC Sim • VBScript

© 2008 Accelrys, Inc. 8 Summary

Data Acquisition & Update

Log & Archive

Modelling & Simulation

© 2008 Accelrys, Inc. 9