Pipeline Pilot PKPD

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How Can Pipeline Pilot Help You? Data Pipelining for Pharmacokinetic-Pharmacodynamic Modelling PKPD Modelling Solutions • Help the modeller by giving access to data from different sources allowing – Integration of Data & Applications – In-depth Analysis • Capture & deploy best-practice processes – Data Sharing & Search Queries – Reporting – Process Automation © 2008 Accelrys, Inc. 2 Typical PKPD Modelling Workflow 1. Data Handling 2. 6. Decision Exploratory Analysis 3. Model 5. Simulation Building 4. Diagnostic & Qualification © 2008 Accelrys, Inc. 3 Typical Workflow in Pipeline Pilot 1 Data Handling 6 2 5 3 – From/To multiple disparate sources, Databases or Files 4 – In-House format checking rules, Logging & Archiving Exploratory Analysis, Diagnostics & Decision Tool 1 6 2 – Advanced Reporting capabilities, Interactive Forms, Charts 5 3 4 – Output formats: HTML, PDF, PowerPoint, Word, Excel, etc. – Portlets integration, JavaScript, AJAX, Flash, etc. 1 Model Building & Simulation 6 2 – Application Integration: NONMEM, WinBUGS, Monolix, etc. 5 3 4 – Job Scheduler 1 Plus 6 2 5 3 – Highly Flexible Visual Programming Language 4 – Integrates R, SAS, M ATLAB , Perl, Java, VBScript, etc. © 2008 Accelrys, Inc. 4 Data Integration 1 6 2 • Databases 5 3 4 • Stored in Files • Generated on the fly • Other Data Type © 2008 Accelrys, Inc. 5 Log & Archive 1 6 2 • Data Analysis 5 3 • Interactive Report 4 • Databases • Reports • Archives • Flat Files © 2008 Accelrys, Inc. 6 Visualisation & Reporting 1 6 2 3 2 5 3 4 2 3. File Viewer 1 1. Job Explorer • Run Summary • Sortable Table Select a Run 2 4 4 4 2 4 2. Model Report • Parameter Estimate 4. Patient Report • Goodness of Fit • Individual Plot • Individual Plot • Goodness of Fit Select a File • Patient Data Table Select a Patient Select a Patient © 2008 Accelrys, Inc. 7 Application Integration 1 1 6 2 Modelling & 6 2 Plus 5 3 5 3 4 Simulation 4 • Command Line • NONMEM • ORACLE • WinBUGS • R • Monolix • MATLAB • Xpose • SAS • WinNonLin • Perl • PsN • Java • simCYP • Python • MC Sim • VBScript © 2008 Accelrys, Inc. 8 Summary Data Acquisition & Update Log & Archive Modelling & Simulation © 2008 Accelrys, Inc. 9.

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