CERCA conference 2019 Barcelona, 30th May 2019

( ,() RIKEN is a comprehensive research institute RIKEN in a nutshell 3

FLOSS1 SciFi SciFi Sell FLOSS1 Naturale Au Au Naturale 1900+ ~€800M 255 Sell

Scientists Budget International SciFi FLOSS1 Collaborations 2500+ Sell Au Naturale Papers published in 2016 500+ 12 8 5.6% 18 Centres Facilities in top 1% of cited papers A wide range of scientific fields 4

Developmental Mathematics Health and Space Science Genetics Sustainable Artificial Nanoscience Resources Intelligence Computational Brain Science Energy Science

Nuclear Plant Science RIKEN has history and vision RIKEN over time 6

Masatoshi Okochi Shinichiro Tomonaga Hiroshi Matsumoto

Jokichi Takamine

Umetaro Suzuki Ryoji Noyori

2015– 1917– 1948– 1958– 2003– RIKEN Scientific RIKEN RIKEN RIKEN private Research public Independent National Research foundation Institute Ltd. corporation Administrative and (KAKEN) Institution Development Institute

Eiichi Shibusawa RIKEN spirit 7

l Innovation first l Basic/frontier science: curiosity-driven research l Application of research results l Fostering talented researchers

l Tackling global challenges l Vision and scenarios for future society The RIKEN way 8

1 Strategic Research Centers 1 2 Research Infrastructure Centers 2 4 3 Cluster for Pioneering Research (CPR) 3 Innovation designers Cluster for Science, 4 help find ways to Technology, and connect society to Innovation Hub research RIKEN pursues fundamental science Cluster for Pioneering Research (CPR) 10

Chief Scientists

ALL-RIKEN Project ALL-RIKEN Project Integrated Symbiology Epigenome Manipulation RIKEN has 9 Strategic Research Centers 11

Integrative Sustainable Brain Biosystems Medical Sciences Resource Science Dynamics Science Research

Accelerator Emergent Advanced Advanced Theoretical Based Matter Photonics Intelligence and Science Science Project Mathematical (RNC) Science Center for Integrative Medical Sciences (IMS) 12

Neurological Skin Next Generation Allergic Infectious Disease Disorder Cancer Immunology Disease Disease Application to stratified cancer therapy Disease Systems Biology Human Immunology Elucidate the mechanisms of disease onset aAVC Pioneer a new area of human immunology and the functional barrier systems that iPS-NKT RK-20449 Elucidation of immune mechanisms maintain body homeostasis in the face of Humanized mouse environmental stress Germ-free mouse Antibodies Metagenomics Bacterial culture

Genetic diagnosis Integrated data analysis Multi-omics GWAS CAGE Genomic Medicine Epigenomics Elucidation of disease onset and biological functions Cellular function Single cell analysis based on functional genomics analysis conversion Center for Sustainable Resource Science (CSRS) 13

Contributing to achieving a sustainable society through transdisciplinary integration of plant science, chemical biology, and catalytic chemistry Center for Brain Science (CBS) 14

l What makes us uniquely human? l Harnessing the universal biological principles of life Center for Biosystems Dynamics Research (BDR) 15

Unraveling what it means to be alive

A , , , Nishina Center for Accelerator-Based Science (RNC) 16 Unraveling the mysteries of the origin of matter Center for Emergent Matter Science (CEMS) 17

Aiming at the discoveries of new principles/materials towards a forthcoming energy revolution Center for Advanced Photonics (RAP) 18 Making the invisible visible: Expanding the horizon of photon science

300 mm Teraphotonics

10-9 eV Δν/ν = 10-18 Quantum 1 eV ≈ 1 mm Attoscience metrology laser1960 109 eV Δt = 10-18 s

Sub-wavelength ≪ λ/2 photonics Center for Advanced Intelligence Project (AIP) 19

Next generation AI technology beyond current deep learning Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS) 20

. Full-scale utilization of modern mathematics to actively promote interdisciplinary research

RIKEN shares largescale research facilities RIKEN has 3 Research Infrastructure Centers 22

BioResource Research Center

Center for Computational Science

Spring-8 Center BioResource Research Center 23

Foundation for Discoveries and Access to the Future

Global distribution of research materials produced in Japan 69 Countries across the world

Number of Institutions Mice 791 Plants 879 Cells 1,369 DNA 768 Microbes 1,292 Total 4,567 Center for Computational Science (R-CCS) 24

Science of Computing by Computing for Computing

Supercomputer Fugaku - The Game Changer - : Expected to be in operation Guaranteed high performance from 2021 thanks to a superb balance of processor speed, memory & network Spring-8 Center 25 Research and development for the world-leading photon facilities RIKEN hosts world class research infrastructure 26

RIBF The Radioisotope Beam Factory houses the SRC - the world’s largest superconducting ring cyclotron K computer Spring-8 Ranked No. 1 on Third-generation Bioresource the HPCG large-scale Research Center benchmark and One of the world’s the Graph500 radiation largest resources for mice, plants, SACLA cells, genes, and X-ray free electron-laser (XFEL) facilities microbes RIKEN is active and productive in frontier science 27

Discovery of element 113 Genetics of AI used to detect (Nh) dreams fetal heart problems

Press conference after IUPAC Discovery of two Automatic detection of officially announced the name genes that abnormalities in fetal the symbol for element 113 regulate the hearts using artificial length of REM intelligence. (dream) sleep. RIKEN brings new/better technologies Technologies developed by RIKEN 29

World #1 in Graph500 Seeing cells from Tiny self-powered & #3 in HPCG outside the body heart monitor K-computer was ranked 1st in Synthetic bioluminescence Ultra-flexible organic Graph500 and 3rd in High could be used to track sensor powered by Performance Conjugate cancer cells or monitor sunlight can act as a self- Gradients (HPCG) Benchmark, brain activity. powered heart monitor. as of Nov. 2018. RIKEN catalyses Full-scale utilization of modern mathematics to actively promote interdisciplinary research 31 RIKEN innovates Cluster for Science, Technology, and Innovation Hub 33

Preventive medicine and diagnosis Innovation program

Other Medical science innovation hub Research program Institutes Private Corporations Drug discovery and medical technology platform program

Compass to healthy life research- complex program

Industrial co-creation Medical Universities Institutions program

Baton-Zone program RIKEN Labs RIKEN has always contributed to industrialization 34

Companies originated from Commercial products based on RIKEN's research the RIKEN Konzern Ricoh Co., Ltd., Riken Vitamin Co., Ltd., KAKEN Pharmaceutical Co., Ltd., RIKEN Food Co., Ltd., RIKEN Perfumery Co., Riken Electric Wire Co., Ltd., Riken Corp., RIKEN Technos Corp., RIKEN Keiki Co., Ltd. Establishment of RIKEN Innovation Inc. (planned within FY2019) 35

100% equity ROI RIKEN

RIKEN Innovation Inc.

Technology Support for Promotion of Membership-based licensing start-ups Joint research co-creation

VC RIKEN tackles global challenges RIKEN as a hub for research on global challenges and sustainability 37

“There are many critical challenges facing humanity, some of which could potentially lead to our extinction. These problems are not simple ones, and cannot be tackled by a single institute or even institutes in a single country or in any given sector. National research and development institutes like my own organization, RIKEN, are in a special place from where we can potentially play a leading role as Surviving in hubs linking industry, academia, extreme heat and government.” Discovery of a gene that — RIKEN President Hiroshi Matsumoto allows plants to survive (STS Forum, 8 Oct 2018) in extreme heat. RIKEN fosters talent Programmes for junior scientists 39 RIKEN fosters talented young scientists and strengths ties between RIKEN and other institutions

Interns & Student Trainees Special Postdoctoral Researchers (SPDR) RIKEN hosts Bachelor/Master’s Fostering autonomous postdoctoral course students: researchers

International Program Associate (IPA) RIKEN Hakubi Team Leader for non-Japanese PhD students Fostering and training young PIs Junior Research Associate (JRA) for Japanese PhD students RIKEN promotes diversity International diversity at RIKEN 41

1900+ 780+ Scientists International faculty & staff

40% 27% 11% East Asia Europe Southeast Asia

19.5% International 9% 8% 3% 2% The Americas South Asia Middle East Oceania (21% of new hires in 2017) + Africa RIKEN seeks higher visibility through further collaboration with Europe RIKEN Overseas Offices and International Partners 43 RIKEN Facility Office at RAL Research collaborations and MoUs : 255 (UK: Rutherford Appleton Laboratory) as of March 31, 2018 KFU-RIKEN Joint Research Labs (Russia: Kazan Federal University)

RIKEN Europe Office RIKEN-Tsinghua RIKEN-MIT laboratory for Neural Circuit Genetics (Brussels) Research Groups (USA: Massachusetts Institute of Technology) (China: Tsinghua University) RIKEN Beijing Representative Office RIKEN-MPG Joint Research Center (Germany: Max Planck Society) RIKEN-KRIBB Joint Research Center (Korea Institute of Bioscience and Biotechnology) RIKEN-XJTU Joint Research Center (China: Xi’an Jiaotong University) RIKEN-SJTU Joint Research Laboratory (China: Shanghai RIKEN-IMP Joint Research Center Jiao Tong University) (China: Institute of Modern Physics, RIKEN-BNL Research Center (USA: Brookhaven National Laboratory) Chinese Academy of Sciences) SIOM-RIKEN Joint Laboratory (China: Shanghai Institute of Optics and Fine Mechanics, CAS) NCTU-RIKEN Joint Research Laboratory US West Coast Collaboration Office (Taiwan: National Chiao Tung University (USA: Lawrence Berkeley National Laboratory, University of California, Berkeley ) RIKEN-NCBS Joint Research Center RIKEN-NTU Joint Research Centre (IndiaNational Centre for Biological Sciences (Singapore: Nanyang Technological University)

USM-RIKEN International Centre for Aging Science RIKEN Singapore (Malaysia: Universiti Sains Malaysia) Representative Office as of November 1, 2018 RIKEN Europe Office 44 l Contribution to RIKEN’s research capacity l Higher visibility in Europe and around l Access to European programs, increased collaboration partners l Acceleration of brain circulation l Contribution to tackling global challenges

Understand Support Network research European STI Activities trends/policies RIKEN Europe Office Anniversary Symposium 45 Cutting-edge STI to shape the future society - One year since RIKEN came to Europe – Date & time: Monday, 2 December 2019, 14:00 – 20:30 Place: Brussels

l RIKEN presentation and discussion to further promote cooperation with European partners l Networking to seek opportunities for collaborative research and innovation towards higher RIKEN’s visibility in Europe l Exchange of Japanese and European research trends and views Tackling global challenges Fundamental research Innovation…

RIKEN seeks higher visibility through further collaboration with Europe