ROSLINREPORTER
Issue 24 December 2011
Roslin and SAC Take to the Stage by Robbie Dalgetty s 2011 draws to a close we Afind ourselves reflecting on a busy but successful year at The Roslin Institute. The move to the new building seems to have been a trigger for a surge of activity and we’ll be riding that wave far into 2012. From the Communications Team, we wish you a jolly festive season.
Inside this issue: inderella hit the (auditorium) stage at The nice to see the Scientists and the Office staff CRoslin Institute this year, with tremendous take a break from the business of Roslin and Director’s Message Page 3 success and unbelievable reviews! SAC and be a little less serious in the lead up The place was packed out with staff from to Christmas. Reflecting On 2011 Page 4 all over the institute, ready to get a giggle at Watching the staff come together and laugh the production staring their co-workers. The at Cinderella was really nice to see, and it Events Page 5 performers did a fabulous job at giving the carried on the The Roslin Institute Building’s classic fairy tale a Roslin Institute Building ethos of co-operation and interactivity. The Roslin In The News Page 7 twist, and even though the production was enjoyment we all got out of watching the only 30 minutes long it didn’t stop them production, no matter how silly or funny it Publications Page 25 throwing in original songs, theatrical rivalries was, showed a clear message - “We are The and even men dressed as women! It was Roslin Institute Building, and we are fun!” Recent Publications 2 Directors Message ell, a lot has happened since the last Wnewsletter, much of which is reported separately so I won’t labour the points. That said I do just want to highlight one or two key items. In a couple of months we will have been in the building for a full year. The snagging jobs are being completed and the new ways of working are starting to bed in and become second nature. I am grateful to everyone who works in The Roslin Institute Building for their patience throughout and I hope everyone agrees that it really is a fabulous place to work. The interest in The Roslin Institute seems to be increasing and we have had a huge number of groups visit from various different areas in terms of discipline and geography. Of these a recent group were the Institute Assessment Panel (IAP) who visited as part of the Biotechnology and Biological Sciences Research Council (BBSRC) assessment of The Roslin Institute. The IAP makes recommendations to the BBSRC in relation to the Institute’s strategic funding and we trust that they enjoyed their visit and were impressed by our science. The paperwork related to the IAP visit has been voluminous and I want to again thank Helen, John, David, Steve, Tony, Andy, Jean, Pete, Mick, Val, Cat, Sonja and Tricia for their work in pulling it together. We’ll know the outcome in March. developing plans for new avian facilities at Our recruitment strategy continues to bear Easter Bush and off-site that will provide state- fruits and we have recently welcomed Peter of-the-art facilities for us and our partners, Simmonds and Tom Wishart (both ex of including the Institute for Animal Health. The University of Edinburgh) to The Roslin Institute campus development will be overseen by Val with Paul Digard (currently Cambridge) set to White whose role has progressed from being join us in January 2012. Peter and Paul both The Roslin Institute’s Director of Operations bring strengths to the virology work of the to being the Campus Operating Officer. Val Institute while Tom is bringing new insights will be undertaking a thorough review of all into neuronal development, stability and campus operations with a view to optimising degeneration. With recruitment to group leader the service support to The Roslin Institute, roles still underway in Quantitative Genetics vet school, SAC and all other tenants on the and Pathology, opportunities for expanding campus. our research capacity are showing no signs of There is much more to report and I encourage slow-down. you to read on to see what we have achieved. With scientific strategy under control and All that remains for my contribution to this the new building up and running I am happy newsletter is for me to wish you all well over to consider 2011 a success. Looking forward the festive period and to say that we’ll see you to 2012, the focus switches to capacity and again in 2012 ready to take on the next grand campus development. The Roslin Institute is challenges.
3 site, introducing a new mentoring scheme, and trialling a new on-line appraisal system. Despite all of this work they still found time to apply for Athena SWAN Silver award, and are looking forward to commencing nominations for the new staff awards in the coming months. Reflecting Colin Miller and the Procurement Team have introduced Sciquest to Roslin users On 2011 this year and they are continuing to work by Val White, with the University to seek improvements to Director of Operations the procurement system. The team continue to interact with a wide variety of suppliers in t’s hard to believe that a year has passed Jane Mitchell has been dealing with the order to achieve some exceptional money Isince I first arrived at The Roslin Institute, complexities of space allocation in a constantly savings deals both on regular orders and one- snow shovel at the ready! A lot has taken moving environment, as well as coordinating off equipment tenders. place and I would like to take this opportunity the decommissioning of the old roslin site. No Tricia Hart and the Communications Team to reflect on the work of the Operations and mean feat, especially while also undertaking a produced a pack of new marketing material early Services Team: new part-time public engagement role for the in the year. These have been used to full effect Tim King with the Small Animal Unit, Poultry College. for the many activities that have taken place Unit and Farms. The farms have been kept The IT Team have been through a difficult (and been coordinated by this team) during busy this past year, with further exciting year with many of their roles being reviewed, the year; Official opening, visit from Chinese research planned over the coming months. despite these changes they have continued to Academy of Sciences, Midlothian Open day, The Small Animal Unit has been focussed work hard on maintaining a fully functioning IT Institutional Review by BBSRC, Highland on rederiving lines into the new facility and service for all in Roslin. Show, Midlothian Council Business Awards the poultry unit has continued to provide an Dawn Law and the Quality Management team, to name but a few. Our public engagement exceptional service, and is looking forward to now including Colin Simpson, have seen their strategy was presented to the BBSRC in the seeing the development of their new facilities, remit encompass electronic data. The team year, highlighting the many new initiatives we which will see them relocating to Easter Bush have been busy relocating the archive store will be focussing upon in the future. There in due course. from the old site to the Alexander Robertson have been ongoing improvements made to the Brian McTeir and his Estates Services Team Building, as well as electronically scanning Intranet and Internet sites throughout the year, have been exemplary in keeping both sites the lab notebooks into an easily referable and along with data gathering and preparation for operational. There have been numerous searchable format. the introduction of the new PURE system (the building snags and other difficulties to Erol and the Finance and Contracts Team University’s research information management overcome in the past year, but as usual their have seen changes within the Team, with system for the next REF). dedication to maintaining services has allowed Margaret retiring this month after 20 years Legal & Business Development again have them to overcome all obstacles in their path. of service and Nicola joining the team as her undertaken fantastic work throughout the Iris O’Neill & Dawn Windsor have worked hard replacement. In addition they have employed year in maintaining business relationships to ensure the labs are maintained to a high an apprentice, Jade. They have been working and managing the contractual relationships standard, allowing us to successfully pass the hard on the development of new financial accordingly. The Industry day was myriad of H&S audits and other inspections reports which will be introduced in the New tremendously successful; the significant with a high standard being maintained. Both Year, as well as maintaining their usual high increase in Industrial partnership awards and Iris and Dawn rely heavily on cooperation of quality contract and finance service. CASE studentships are closely linked to the all laboratory staff in order to successfully Cat and the HR Team have been busy with follow up activities from this event. maintain the standards achieved, and are a wide variety of recruitment campaigns this Last, but by no means least, the DA Team of grateful to all for their contribution. year, as well as introducing a new look intranet Gila, Sheelagh, Liz, Val, Anne and Joan who have been working tirelessly in the background ensuring that our post, travel & diary management, events, seminars, publication lists, committees etc. are all maintained for the divisions. Overall a big THANK YOU for everyone in the Team for their ongoing commitment and dedication to Roslin Operations, it has been a pleasure to work with you all. As many of you are aware, I have just undertaken a new role as Easter Bush Campus Operations Officer. This role will allow both The Roslin Institute and the Vet School to maximise the benefits of a merged campus, and create a collective sense of purpose across the campus for the Operations Team. I will still continue to have operational oversight for The Roslin Institute in this role and I shall look forward to leading you through the many challenges of 2012 in due course. 4 Events
any seminars, workshops, conferences and other events are now listed on The Roslin MInstitute web site (http://www.roslin.ed.ac.uk/events).
Please check the site for updates and if you would like to have your event posted, please contact Tricia Hart ([email protected]).
he seminar programme is organised Tby a committee of volunteers: Neil Mabbott (Neuropathogenesis, Chair) Mark Bronsvoort (Genetics and Genomics) Andrea Wilson (Genetics and Genomics) Neil Anne French (Veterinary Clinical Sciences) Vicky MacRae (Developmental Biology)
Bob Dalziel (Infection and Immunity) Andreas Lengeling (Infection and Immunity) For full listings please visit http://www.roslin. ed.ac.uk/events.
Jan 11th Dr Piero Carninci Omics Science Center, RIKEN Yokohama Institute, Japan Host: Geoff Faulkner “The complexity of mammalian transcription”
Jan 18th Dr Alexander Medvinsky Inst. Stem Cell Res., Univ. Edinburgh, UK Host: Adam Balic “Tracking development of haematopoietic stem cells in the mammalian embryo”
th EBRC SEMINAR SERIES Jan 25 Dr Tim Bull St. George’s Univ. London, UK Host: Jayne Hope “TBC”
Feb 1s t Dr Duncan Maskell Univ. Cambridge, UK Host: Ross Fitzgerald “TBC”
Feb 8th Dr Peter Carlsson Univ. Gothenburgh, Sweden Host: Jeanette Johansson “TBC”
Feb 22nd Dr Ian Deary Univ. Edinburgh, UK Host: Jean Manson “Cognitive ageing and cognitive epidemiology in the Lothian Birth Cohorts of 1921 and 1936”
Feb 29th Dr Phil Jones Univ. Cambridge, UK Host: Denis Headon “TBC”
Mar 7t h Dr David Brough Univ. Manchester, UK Host: Barry McColl “TBC”
Mar 14th Dr Laura Green Univ. Warwick, UK Host: Steve Bishop “TBC”
Mar 21st Dr Mathias Gunzer University Duisburg/Essen, Germany Host: Andreas Lengeling “TBC”
5 his seminar programme is organised Tby Sionagh Smith, Lecturer in Veterinary Pathology at the R(D)SVS. These monthly seminars are attended by pathologists from the Vet School, Medical School, Mordeun Research Institute, Scottish Agricultural College, Veterinary Laboratories Agency, members of local Biomedical/ Pharmaceutical industry in addition to researchers and clinicians. They cover both naturally-occurring disease in domestic species (diagnostic pathology) as well as experimental pathology in laboratory animals (including animal Sionagh models of human disease). The series is hosted by the R(D) SVS Veterinary Pathology Unit in association with the British Society of Veterinary Pathology. The seminars are accredited by the Royal College of Pathologists and attendees receive 1 CPD credit per seminar. This seminar series will take place in The Roslin Institute Building and all Pathology Seminar Series are welcome. If you would like further Veterinary and Comparative information please contact Sionagh ([email protected])
Edinburgh Mouse Club he Edinburgh Mouse Club meetings take place at George Square. For more Tinformation, please contact Andreas Lengeling ([email protected]) or check for news at www.roslin.ed.ac.uk/emc/
Andreas
6 Roslin in the News
his is a selection of the press releases to Thave been issued from The Roslin Institute in 2011. To discuss any of these with the Institute’s Press Officer, please contact Tara Womersley on 0131 650 9836
The Roslin and Professor Bruce Whitelaw NewVectys join forces to generate breakthrough innovations for Human and he Roslin Institute and NewVectys are agreement will reinforce the links between Tpleased to announce that they have The Roslin Institute and NewVectys, and will Animal Health signed a general collaboration agreement facilitate new projects addressing human with the objective of generating breakthrough and animal health issues, such as infectious innovations to address major challenges in diseases and regenerative medicine. “ human and animal health. Both parties will NewVectys is a French biotech company join their forces and complementary skills in developing leading-edge genetic engineering the fields of vectorology, genetic engineering technologies. The company offers advanced and animal biotechnology. customized tools for biomedical research The Roslin Institute and NewVectys already including bio-safe vectors and large animal cooperate on designing and developing models. NewVectys also develops advanced new technologies for biomedical research, therapies, taking advantage of its proprietary providing advanced solutions to accelerate technologies and leveraging its unique development of new and effective disease network of research partners and 2 decades of therapies. research experience in genetic engineering. Professor Bruce Whitelaw, Head of the Institute’s Division of Developmental Biology said of the agreement, “This collaboration
7 Hong Kong Visit delegation led by Donald Tsang, Chief Sir Ian Wilmut agreed that the visit highlighted AExecutive of the Government of Hong the strong links between the two countries. Kong, visited The Roslin Institute in September ‘Degenerative and genetic diseases are not 2011. The visitors learned about stem cell and Scottish problems or Chinese problems. regenerative medicine research in Edinburgh They are global problems that will require and discussed a proposal for a joint research collaborative solutions. The Hong Kong institute based in China. Government is clearly taking proactive steps to After being greeted by the University of ensure that Hong Kong remains at the forefront Edinburgh’s Principal, Sir Timothy O’Shea, of innovation and commercialisation of research The Roslin Institute Director David Hume, in the coming years.’ and Chairman of the Scottish Centre for Regenerative Medicine, Sir Ian Wilmut, the delegation toured the new Roslin Institute building. The group also viewed plans to create a joint stem cell and regenerative medicine research institute based in China. The Chief Executive noted that Hong Kong has a long history of innovation and is renowned for its favourable business climate. He was ‘impressed with the cutting edge research in Edinburgh’ and hoped ‘that collaborative projects will emerge between Edinburgh and universities in Hong Kong.’
Roslin Scientists Report Genetic Resistance to TB esearchers at The Roslin Institute have stream as well as Defra funding and together Ridentified the potential to breed cattle with they have been studying the Holstein breed of an increased resistance to bovine tuberculosis dairy cattle to assess the variation between (bovine TB). individuals of resistance to bovine TB. Bovine tuberculosis is just one of the many Liz Glass’s team, in collaboration with endemic diseases that persist in UK farm colleagues from Queen’s University Belfast animals and it is estimated to have cost the and the Agri Food and Biosciences Institute in UK economy £90 million in 2010 and is on the Northern Ireland, has found that some degree rise. Like many endemic diseases of farmed of resistance to bovine TB is inherited and animals – those that are always present in the team has also identified genetic markers a region – TB is a serious drain on farming, associated with resistance. These results mean undermining attempts to ensure food security that it might be possible to selectively breed as well as significantly affecting the welfare of cows that are more resistant to the disease. farmed animals. The group is now working with an industrial Funders including the Biotechnology and partner, DairyCo, to explore the possibility of Biological Sciences Research Council implementing selection for increased resistance and the Scottish Government launched an in commercial dairy cattle. Liz John Steve initiative called CEDFAS (Combating Endemic For more information about this work, see the Diseases of Farmed Animals for Sustainability) publication: Bermingham ML, Brotherstone in 2007 in order to enable scientific research S, Berry DP, More SJ, Good M, Cromie AR, that could improve our ability to manage some White IM, Higgins IM, Coffey M, Downs SH, of the most costly diseases of UK livestock, Glass EJ, Bishop SC, Mitchell AP, Clifton- among them bovine TB. Hadley RS, Woolliams JA. 2011. Evidence for Scientists at The Roslin Institute, including genetic variance in resistance to tuberculosis Professors Liz Glass, Steve Bishop and John in Great Britain and Irish Holstein-Friesian Woolliams have benefited from this funding populations. BMC Proc. 5 Suppl 4:S15.
8 DNA find sheds light on the Human Brain rain cells alter their genetic make-up during provides us with new information about how the Ba person’s lifetime, scientists have found in brain works. If we can understand better how a discovery that could shed light on neurological these subtle genetic changes occur we could diseases. shed light on how brain cells regenerate, how Researchers from The Roslin Institute, at the processes like memory formation may have a University of Edinburgh, have identified genes genetic basis and possibly link the activity of – known as retrotransposons – responsible for these genes to brain diseases.” thousands of tiny changes in the DNA of brain The study shows for the first time that brain tissue. cells are genetically different to other cells in Researchers, whose work is published in the body and are also genetically distinct from the journal Nature, found that the genes were each other. particularly active in areas of the brain linked to Scientists are now researching whether brain cell renewal. tumour formation and neurodegenerative By mapping the locations of these diseases such as Alzheimer’s are associated retrotransposons in the human genome, with a change in retrotransposon activity. scientists could identify mutations that impact The research was carried out in collaboration on brain function and that may cause diseases with scientists from Holland, Italy, Australia, to develop. Japan and America. It was funded by the Dr Geoff Faulkner (left), of Wellcome Trust, the Biotechnology and The Roslin Institute at the Biological Sciences Research Council and University of Edinburgh, the Australian National Health and Medical said: “This research Research Council. Images completely overturns the For more information about this work, see the courtsey of Welcome belief that the genetic make- publication: Baillie JK et al. Nature. 2011 Oct up of brain cells remains 30;479(7374):534-7 static throughout life and
Study could help battle against Superbugs to high fever, toxic shock and potentially fatal the National Institutes of Health, USA, the US lung infections. The study, published in the Department of Agriculture and Pfizer Animal journal PLoS Pathogens, will help research to Health. find drugs that could target SElX and prevent Gill Wilson, of The Roslin Institute and first damage to healthy cells. author on the paper, said: “MRSA continues to The research, carried out by the Universities of be a global problem. This research could help Edinburgh, Iowa and Mississippi State, looked us find a new way to target the infection.” at a strain of MRSA known as USA300 that can For more information about this work, see cause severe infections in otherwise healthy the publication: Wilson, GJ et al. (2011). “A argeting a toxin released by virtually all individuals. Novel Core Genome-Encoded Superantigen Tstrains of MRSA could help scientists MRSA strains are known to produce different Contributes to Lethality of Community- develop new drugs that can fight the superbug, types of toxins but scientists found that SElX is Associated MRSA Necrotizing Pneumonia.” research suggests. made by virtually all strains of the superbug. PLoS Pathogens 7(10): e1002271. A study led by the University of Edinburgh has It belongs to a family of toxins known as discovered the toxin – SElX – which leads the superantigens, which can invoke an extreme body’s immune system to go into overdrive and immune response. damage healthy cells. Dr Ross Fitzgerald, from The Roslin Institute The toxin SElX is made by 95 per cent of at the University of Edinburgh, said: “If we can Staphylococcus aureus bacteria, including find ways to target this toxin, we can stop it MRSA strains linked with hospital-acquired from triggering an over-reaction of the body’s infections. immune system and prevent severe infections” When it is released it triggers an over The research was funded by the Biotechnology multiplication of immune cells, which can lead and Biological Sciences Research Council, Ross
9 Chicken Virus sheds light on how Human Cancers Develop Sciences Research Council (BBSRC), identified a gene – called IRG1 – that makes chickens more susceptible to the disease. The gene is thought to cause the death of cells, which can in turn lead to diseases including cancer. Researchers also found how the Marek’s disease virus may also encourage tumour growth. Chickens and mammals, including humans, have anti-tumour mechanisms, one of which is controlled by a gene called HIC1. HIC1 switches on lots of other genes which have anti-tumour effects. resh discoveries about a disease commonly Marek’s disease virus switches off the genes increases the risk of Marek’s disease could help Ffound in chickens could improve our controlled by HIC1 – in other words, it turns off us breed chickens that are less susceptible to understanding of some types of cancers in key genes that would normally work to block infection.” people. tumours. “Also, learning about how chickens affected The study into Marek’s disease could also These genes are also linked to fighting tumours by Marek’s disease fail to combat the onset of have major implications for the poultry industry, in humans and the study could help research tumours will help us learn more about how certain making it possible to breed birds with greater into preventing of some types of cancers in viruses can trigger cancer in humans.” resistance to the disease. people, which like Marek’s disease, are caused The research, funded by the Biotechnology Scientists analysed thousands of genes to by viruses. and Biological Sciences Research Council, is pinpoint those that play a role in Marek’s disease Such viruses include the human papilloma virus, published in the Journal of Virology. – a viral infection that costs the global poultry which can lead to cervical cancer, and Kaposi’s For more information about this work, see the industry more than £1.4 billion a year. sarcoma, which affects patients with HIV. publication: Smith J et al.2011. Systems analysis The research from The Roslin Institute at the Professor Pete Kaiser, of The Roslin Institute of immune responses in Marek’s disease virus- University of Edinburgh and the Institute for who led the research, said: “Marek’s disease infected chickens identifies a gene involved in Animal Health, both of which receive strategic is highly contagious in chickens and creates a susceptibility and highlights a possible novel funding from the Biotechnology and Biological heavy economic burden. Identifying a gene that pathogenicity mechanism. J Virol 85(21):11146-58
Neil Mabbott, of The Roslin Institute, who led the study, said: “If we can find a way of stopping Protein provides this protein from being expressed by specific immune cells then we could potentially block the spread of the disease to the brain. We also want insight into to understand how cells are infected with vCJD in the first place, so that we can look at ways of spread of vCJD stopping this from happening and find ways to diagnose the disease at its early stages.” The study, funded by the Biotechnology and to the Brain Biological Sciences, looked at production of the For more information about this work, see the protein – called PrPC – in specific immune cells. publication: McCulloch L et al. 2011.Follicular These cells – follicular dendritic cells – act like Dendritic Cell-Specific Prion Protein (PrP) protein linked to the immune system could spider’s webs, attracting foreign particles, which Expression Alone Is Sufficient to Sustain Aplay a key role in helping scientists understand can then be disposed of by the body’s immune Prion Infection in the Spleen. PLoS Pathog. how vCJD spreads throughout the body. system. 7(12):e1002402 Researchers found that they could thwart the The researchers found that when the cells spread of vCJD by preventing production of the expressed PrPC, corrupted proteins responsible protein in just one type of immune cell. for vCJD, known as prions, were able to replicate The study by The Roslin Institute at the University and spread throughout the body. However, when of Edinburgh could lead to treatments to stop the cells were prevented from producing PrPC, vCJD spreading from the spleen, the original the prions were not able to multiply and were site of infection, to the brain where the disease destroyed by other cells. destroys nerve cells. Stopping these cells from expressing this protein However, any treatments would be viable only if did not affect the regular function of the immune scientists are able to find a way to diagnose the system. The study is published in the journal Neil condition in its early stages. PLoS Pathogens.
10 Dissecting Molecular Pathways Involved in Ovulation by Xavier Donadeu ver the past few decades there has The next step was to investigate whether Obeen a persistent decrease in livestock this novel finding indicated a role of PLCβ3 fertility in western countries. This has been in mediating ovulation. To do this we used associated with the derivation and use of a primary bovine follicular cell culture genetically improved breeds as well as with initially developed at The Roslin Institute to the consolidation of livestock industries into specifically downregulate PLCβ3 levels in fewer, larger, intensively managed production those cells using RNA interference (RNAi). units. Through this approach we wanted to ascertain A clear example is the dairy cattle industry, specifically whether PLCβ3 was indeed where conception rates are currently at an all- essential for follicular cells to respond to LH time low of about 40% resulting in extended during ovulation. Our results demonstrated calving intervals and premature culling. Poor that different ovulatory responses to LH were fertility in dairy herds is estimated to cost to indeed partially or totally impaired in cells with the UK industry over £300 million a year, in an induced deficiency in PLCβ3. addition to being a major welfare issue. The results of this study provide a new A major underlying cause of low fertility in cattle molecular target for strategies aimed at is the absence of cyclic ovulatory activity after increasing fertility in livestock. In future parturition which delays conception and overall studies we would like to better characterise the productivity. Therefore, an understanding of specific roles of PLCβ3 during the ovulatory the physiological mechanisms involved in process and to confirm such mechanism in ovulation will be essential to develop strategies other species. to increase fertility in livestock. For more information: Donadeu FX et al. 2011. Our laboratory is interested in characterising Phospholipase Cβ3 mediates LH-induced the cell signalling pathways involved in granulosa cell differentiation. Endocrinology. ovulation, as this may allow identification of 152(7):2857-69. potential molecular targets to manipulate fertility. It was believed for a long time that the only trigger for ovulation in most species was activation of cyclic AMP release by luteinising Photomicrographs(magnification,x400)showing hormone (LH) in ovarian follicle cells. We immunostaining of PLCβ3 (Top panel) and PLCβ1 and other laboratories had shown earlier that (Bottom panel) in ovarian follicular cells showing another major signalling pathway involving the differential localisation of these two different enzyme isoforms in cytoplasm and nucleus, phospholipase Cβ family of enzymes may also be involved although this had so far not been respectively. Our results indicated that an increase Xavier in PLCβ3 levels in the membrane of follicular cells proven in a physiological context. Therefore, is necessary for ovulation. we decided to carry out gene expression analyses of bovine tissues to ascertain whether specific cell signalling pathways other than the cAMP pathway were upregulated during terminal different ovarian follicles leading up to ovulation. We found that among different PLCβ isoforms, PLCβ3 was specifically and dramatically (about 20-fold) upregulated in bovine follicular cells before ovulation.
11 Other News
he Roslin Institute’s new £60 million Tbuilding was officially opened in June by The Rt. Hon. Alex Salmond MSP, First Minister of Scotland. The First Minister was joined by Professor David Hume (Director of The Roslin Institute), Professor Bill McKelvey (CEO of the Scottish Agricultural College), Professor Douglas Kell (CEO of the Biotechnology First Minister and Biological Sciences Research Council (BBSRC)) and Professor Sir Tim O’Shea (Principal of the University of Edinburgh) Attends Official in hailing the building as providing a huge opportunity in Scottish Animal Biosciences. Opening of The Professor David Hume, the Director of The Roslin Institute said: “The new building is Roslin Institute designed to maximise cooperation amongst our experts. Our new home will help us tackle complex problems ranging from fertility and Building reproduction through the threats of diseases by the shape of a pair of chromosomes, with such as avian flu and tuberculosis to animal a rainbow progression of coloured panels that welfare and greenhouse gas emissions. We link offices with research laboratories. now have an iconic building that is instantly The three-storey building covers 14,000 recognisable.” square metres. Open-plan working spaces, Alex Salmond, Scotland’s First Minister with break-out areas, are designed to said: “Scottish science has an international encourage collaboration between scientists reputation for quality, and the ground-breaking from different disciplines. The building also work of The Roslin Institute is already famous contains an auditorium and meeting facilities. worldwide. This new home here at the Professor Bill McKelvey said: “This builds University’s Easter Bush campus gives an on a long track record of cooperation and opportunity for further advances.” collaboration between SAC, The Roslin The Institute, sited at the University of Institute and the University of Edinburgh and Edinburgh’s Easter Bush Campus, replaces opens up opportunities for even greater things the former home of The Roslin Institute, where to come. The kinds of research that are needed Dolly the Sheep was cloned, in the nearby to address today’s ‘Grand Challenges’ span the village of Roslin. range from new fundamental understanding of Professor Douglas Kell, Chief Executive biology to practical innovation. That is what of the BBSRC, which provided a significant is so appealing about the combination of component of the funding for The Roslin scientists from SAC and the University cheek Institute Building said: “This new building, by jowl in the same building.” constructed with significant support from Prof McKelvey gratefully acknowledged the BBSRC, will house world-class science that financial assistance of the Scottish Government tackles some of the most important challenges Rural and Environmental Science Directorate we face. These high-quality facilities will in supporting SAC’s investment. enable scientists to do research that supports The new building forms part of a £100 million and enhances human and animal health, food development at the University of Edinburgh’s security, and social and economic well being Easter Bush campus, which includes a new in the UK and beyond.” teaching building for the Royal (Dick) School The design of The Roslin Institute was inspired of Veterinary Studies.
12 EBRC Team Funded to Develop New Vaccines by Maggie Bennett, Communications Manager, Moredun Research Institute cientists at The Roslin Institute are of an industrial partner, AbD Serotec. This Scollaborating with partners at the Moredun will ensure that the techniques and reagents Research Institute to learn more about the developed in the project will be widely available immune systems of livestock and develop to the scientific community in order to support sheep and cattle vaccines. The project, led future vaccine research. by Moredun’s Professor Gary Entrican and Liz Glass said of the funding, “Jayne Hope involving Roslin’s Professor Liz Glass and Dr and myself are delighted to be collaborating Jayne Hope, is funded by a grant of nearly with Prof Entrican at the Moredun Research £1 million from the BBSRC and the Scottish Institute on this prestigious project. The impact Government. of pathogens on the livestock industry remains With the global population continuing to grow, a barrier to greater productivity. Understanding food security is becoming a real challenge. There how the ruminant innate and acquired immune is a pressing need to apply new technologies systems interact is essential for the development and knowledge to help ensure sustainable, safe of effective vaccines targeted to both endemic and healthy food supplies, while reducing the and exotic infectious diseases of livestock. We impact on the environment. Effective vaccines consider that focusing on immune components are the most efficient way of preventing the of both cattle and sheep together will be transmission and spread of infectious diseases synergistic and fantastic value for money”. in cattle and sheep. However there are still The Roslin Institute and the Moredun Research many diseases for which no effective vaccines Institute are partners in the Easter Bush exist and the lack of knowledge of the immune Research Consortium (EBRC) along with the systems of these animals is considered to be a Scottish Agricultural College and Royal (Dick) major block to strategic vaccine development. School of Veterinary Studies. Professor David This major funding will enable the Moredun Hume, Director of The Roslin Institute said of and Roslin Institutes’ researchers to undertake the project, “The partnerships of the EBRC detailed investigations of the immune responses have been very effective in the past and this of sheep and cattle, vitally underpinning the is another excellent example of the strength Liz Jayne Garry development of vaccines in the future. The work the consortium brings in building the Animal will be done in conjunction and with the support Sciences sector in Scotland and the UK.”
Visit by Chinese Academy of Sciences delegation of Senior academics and ADirectors from the Chinese Academy of Sciences (CAS) visited The Roslin Institute in June. The purpose of the visit was to gain an understanding into how the research activities of our Institute are supported Operationally. A series of lectures were presented by Val White, Cat Eastwood, Sonja Vujovic and Patricia Hart providing an overview of the operations within the Institute. The lectures were well received by CAS, with animated debate taking place over our HR and Public Engagement activities. The delegation ended their visit with a tour of the building.
13 n Saturday 10th September The Roslin OInstitute threw open its doors to give Roslin Opens people in the local area a unique chance to engage with the scientists working in the new by state-of-the-art building. its Doors to Mike The event provided an opportunity for Davies researchers to explain their science and the Public (BBSRC) how it benefits people by contributing to the UK society and to economic growth. It also provided a forum for local people to talk to scientists to express their views on the research undertaken in the Institute. The Roslin Institute opened its doors as part of the Midlothian Doors Open Days programme. Over 550 people of all ages visited the institute where 70 of Roslin’s scientists were on hand to talk about their role in helping to improve the health and welfare of livestock animals and the sustainability of the livestock sector. Visitors were able to engage with Roslin’s science at 21 interactive exhibits spread throughout the building which covered subjects as diverse as the science of healthy bones and the life of a PhD student. A series of talks ran during the day which finished with an interactive discussion on the ethics of producing genetically modified animals. Professor Helen Sang, a research leader at Roslin who helped to organise the day, said “I think it’s really important that we find occasions like this to explain our science to the public and get their opinions on it. There was a great buzz around the Institute today with researchers engaged in really interesting and constructive conversations about their research with local people and I think everyone involved really enjoyed it.”
14 15 Student Day By Liz Archibald he annual Royal (Dick) School of Veterinary surroundings. The high quality of both oral TStudies (R(D)SVS) research student day and poster presentations certainly posed a took place on 12th May 2011 at the new Roslin hard task for the various session judges all Institute Building. of whom commented on the quality of the The R(D)SVS postgraduate convenor, Dr students’ work and the difficulty of choosing Bernadette Dutia welcomed everyone to the winners. As one of the judges commented, the event and introduced the day. Students took standard of posters was higher than at some part from across the Easter Bush Research international meetings. Consortium (EBRC), which is made up of The day’s presentations were concluded by The Roslin Institute, the Scottish Agricultural Professor Russell Foster (Nuffield Laboratory College, the Moredun Research Institute of Ophthalmology, University of Oxford) who as well as R(D)SVS. Their presentations gave an inspiring and entertaining keynote highlighted the diverse range of research lecture entitled “Light, Clocks and the within the School and the wider EBRC. Regulation of Rhythmic Physiology in Birds Seventeen final year PhD students gave and Mammals”. oral presentations and a further 70 students, After the formalities of a full day’s programme, made up of PhD, MSc and Clinical Scholars, an informal reception and prize giving presented posters detailing their research. ceremony took place. Professor David Hume The event showcased the excellent research and Professor Bruce McGorum congratulated that our students undertake and provided the students on the high quality of the an opportunity for students to present their presentations and presented the certificates work to staff and fellow students in familiar and prizes to the winners.
Prizes were awarded for: First year poster winner: Rachel Huddart First year poster runner up: Edward Johnson Second year poster winner: James Vincenti Second year poster runner up: Paul McAdam Third year poster winner: Kayleigh Iremonger MSc/Clinical Scholar poster winner: Russell Parker Oral presentation winner: Rachael Baker Oral presentation runner up: Joni Macdonald Oral presentation runner up: Julio Rodriguez-Andres 16 Roslin Director welcomes new Head of Vet School rofessor David Argyle, whose research Pgroup is part of The Roslin Institute’s Division of Developmental Biology, has been appointed as the new head of the Royal (Dick) School of Veterinary Studies at the University of Edinburgh. Professor David Hume, Director of The Roslin Institute, was among the first to congratulate David on his appointment saying, “This is great news for the vet school and for The Roslin Institute. David Argyle has been a key member of Institute’s research team since 2008 and has been instrumental in bringing the clinical research of the vet school into close contact with that of the Institute. I look forward to developing the Institute-Vet School relationship further with David.” David Argyle told staff across the Easter Bush Veterinary Campus that he is “absolutely delighted to accept the post of head of school“. He also thanked his predecessor, Professor Professor Argyle is a Royal College of Oncology. He has held the William Dick Chair Elaine Watson, for doing an “outstanding job Veterinary Studies and European Specialist of Clinical Studies at the University since 2005 in establishing an incredible infrastructure on in Veterinary Oncology and Diplomat of the and headed up the University’s Veterinary the campus.” European College of Internal Medicine in Cancer Care Centre since it opened in 2009.
New Proteomics Facility at Roslin By Andy Gill spectrometers, sophisticated instruments altered under specific circumstances, such that can measure the molecular mass of as disease. A key part of the methodology small peptides and proteins, carbohydrates, of both proteomics and metabolomics is to lipids and other biomolecules. We now have be able to separate out complex mixtures of two mass spectrometers, one that will be molecules and this typically involves HPLC optimised for proteomics work and one that is separations – doing this ‘online’, such that the set aside for the analysis of small molecules output from the HPLC goes straight into the and metabolomics. Implementing the new mass spectrometer, provides a streamlined facility represents an exciting new journey for workflow. protein research at The Roslin Institute and As with all sophisticated instrumentation, a n May 2011, The Roslin Institute took receipt we hope to provide expertise that all scientists dedicated person is necessary to run it and Iof several rather large cardboard boxes. can use.” provide technical expertise. Dr Dominic Kurian Although they were inconspicuous - plain For those not familiar with the terminology was recruited in October 2011 and has been brown, with few markings - this was a very used, proteomics is essentially the analysis of hard at work ensuring that all equipment is exciting and significant delivery. This delivery the entire protein repertoire of a organism, in working at its optimum. Andy Gill says, “We marked the beginnings of a new, fledgling the same way that genomics is the study of have been particularly fortunate to recruit a facility to provide expertise in protein and small organisms’ genes, transcriptomics is the study scientist of Dominic’s calibre to The Roslin molecule analysis at the Easter Bush Campus. of the transcripts etc. However, rather than Institute to oversee the new PMR facility. The investment represents a strategic move to simply define the total protein complement, I personally am excited to be working with enhance protein analysis at Roslin. Now the a typical proteomics experiment involves Dominic and I know that he will bring significant equipment is in place we are full steam ahead detecting and identifying those proteins that expertise in many aspects of proteomics. I with all instrumentation undergoing testing may be differentially expressed under specific would encourage any scientists at the Easter for QC purposes ahead of throwing open the conditions, or those that localise specifically to Bush campus who would like to discuss the doors. The new facility will be Proteomics and particular sub cellular organelles, or those that new facility to get in touch with Dominic. We Metabolomics at Roslin (PMR) and is located associate in a complex with another specific will also be running a series of presentation in the first floor, west wing of the new Roslin protein etc. ‘roadshows’ in the new year to highlight the Institute Building. There are many possible experiments that kind of information that our new facility will be Providing scientific oversight to the new facility can be performed. Metabolomics is similar, able to provide. is Andy Gill, who said recently “The funding but deals predominately with small molecule For more details, staff should contact Dr Andy has been spent predominately on mass metabolites, the levels of which may be Gill or Dr Dominic Kurian
17 Family Day aving talked constantly about the new HRoslin Institute Building for many months, once we were settled we thought it might be fun to invite our nearest and dearest to visit The Roslin Institute’s new home. So in May we did just that. It was an opportunity for folks to take their families on a tour of the building and to show them their places of work. There were also some fun opportunities to encourage younger family members to follow in the footsteps of parents and catch the science bug. Many thanks to Jane Mitchell and all those involved in the organisation of this event. “Dr Poo” of the SAC (aka Jos Houdijk) ran a competition for young visitors to colour in the nematodes he had on show. The winner of his prize for best picture was Isla Penny.
18 19 Girl Guides By Pip Beard
n October 24th twelve members of 1st diagnosing diseases using microscopy, OGorebridge Guides were given a behind and spoke to Jo Stevens about a career as the scenes visit to The Roslin Institute and a research scientist and life at The Roslin Royal (Dick) School of Veterinary Studies in Institute. Edinburgh. They had a tour of the veterinary The girls were fascinated by all that they learnt hospitals in the morning, enjoyed lunch in and were surprised to see so many young Dolly’s, and then walked around The Roslin women scientists among the Roslin staff. One Institute Building before spending the afternoon commented, “They don’t look like scientists”. learning about science. The Guides would like to thank The Roslin The girls were taught by Clare Pridans and Institute and in particular Claire, Maggie, Jo and Maggie Davis how to extract DNA from a Tricia for the opportunity to visit and learn about kiwifruit, tried their hand at pathology by the varied careers open to women in science.
Bone Society he Bone Research Society (BRS) is (BORS) conference was held at the University Staines, Dongxing Zhu, Ross Dobie and Tthe largest scientific society in Europe of Cambridge in June and it had a high Neil Mackenzie) were selected to be oral dedicated to clinical and basic research into representation of Roslin Institute scientists. presentations. This is highly significant as no mineralised tissues, and is the oldest such More than 230 abstracts were submitted other University/Institute received as many oral society in the world. This year’s joint BRS to this meeting and all five abstracts from presentations and highlights the quality of the and British Orthopaedic Research Society Roslin scientists (Carmen Huesa, Katherine Bone and Calcification research ongoing within The Roslin Institute. Dongxing Zhu and Neil Mackenzie, both working in Vicky MacRae’s Vascular Calcification group, have been awarded BRS New Investigator Awards for particularly high scoring abstracts, as voted for by the BRS committee. Two weeks after this conference the BRS also organised a Young Investigators’ Workshop which was run by young researchers who have recently been awarded fellowships/ lectureships. The aim was to help post- docs and final year students to carve out a successful career in the bone/cartilage arena. This workshop was attended by Katherine Staines, Dongxing Zhu and Neil Mackenzie and discussed vital skills such as grant writing, data presentation and how to market one’s self effectively, as well as providing an excellent opportunity for networking.
20 The Roslin Institute at the
pril was the month of the Edinburgh AInternational Science Festival (www. sciencefestival.co.uk/). More than 200 events took place at 38 venues throughout the city of Edinburgh. Activities ranged from lectures to scientific demonstrations as well as many hands on activities. Gwen Wathne, a PhD student in The Roslin Institute’s Neurobiology Division, reports on her involvement and that of other Roslin staff.
Roslin Director meets public in the middle By Gwen Wathne uring the Edinburgh International Science sold in the UK is imported. In many parts of DFestival I attended a talk by, Professor the world the food production is nowhere near David Hume, not the famous philosopher but enough to sustain the population living in those the director of The Roslin Institute (although areas, and this problem will continue to grow Roslin’s David Hume enjoyed the idea that and become more widespread as the world’s there was already a statute of him when he population increases. moved to Edinburgh from Australia in 2007). One of the main aims of The Roslin Institute The talk was entitled “Meat me in the middle”, is to breed animals to be healthier and more covering the issue of food security and productive. This also takes into account generally informing the audience about the improving animal welfare; happy animals work The Roslin Institute is doing in this area produce more milk or meat and therefore fewer and what the industry is aiming to achieve by animals are used to produce greater quantities carrying out this type of research. of food. This also decreases the environmental Many people may well be wondering why, impact of using animals for food production. when public opinion is still divided over the While many people might be against the idea acceptability of genetically modified food of eating genetically modified food products, products, so much money has been spent most of what we eat has already been modified on developing these products, and more or selected in some way, at some point, and importantly, why this research and development Professor Hume, finished off the talk by asking is being carried out. The answer, Professor everyone to think about what they would be Hume says, is in the fact that even today there prepared to eat, if they were starving? It is is not enough food being produced in the UK to a question that we are all going to have to feed all the people living here, much of the food consider in the years to come.
21 Flu Fighters By Gwen Wathne charming volunteers to answer any questions the public might have. Build a virus was available for the younger visitors and was a resounding hit. Yet, while there were other activities and games available for the older kids and adults such as the epitope puzzle, word searches and crossword puzzles, the sight of Play-Doh re-ignited the inner child, and there were frequently as many adults and teenagers as children making the viruses. This The University of Edinburgh organised did provide us with some very rather ‘different’ ‘Discover Science’, which incorporated 13 looking viruses than one might expect to see in different activities from nine different schools a textbook or down a microscope, but proved or centres in the College of Science and educational and entertaining nonetheless. Engineering and drop-in activities contributed Another great draw were the giant microbes by five different centres from the CMVM. http://www.giantmicrobes.com/uk/
Gwen Stands up for Science By Gwen Wathne ast month I attended the ‘Standing Up their ‘ask for evidence’, encouraging scientists LFor Science’ media workshop run by to request proof of scientific claims for a wide Voice of Young Science (VoYS) http://www. range of products like ‘detox’ solutions. senseaboutscience.org/pages/voys.html. The VoYS is an expanding network of young workshop was aimed at raising awareness of scientists who are passionate about their field how young scientists could better communicate and want to make it easier to set the record their science and I was surprised to find straight about common myths and encouraging out that a surprising number of people are people to speak up about science. This was not even aware that their University has a an opportunity for young researchers to voice dedicated Press Office. their fears or concerns about talking about their The day was split into three sessions chaired research or science in general, engendering by scientists from the Universities of Glasgow some very interesting discussions with the and Edinburgh, journalists from the BBC, panellists. Daily Mail, and the Herald, Sunday Herald, VoYS is always looking for volunteers or new and Evening Times, as well as The Roslin members for their network. Lindsay Hogg is Institute’s very own press and PR officer, Tara going to be the Scottish coordinator for Sense Womersley. about Science, which is just starting up, and she VoYS is a programme run by Sense about will also be involved in coordinating the Scottish Science:http://www.senseaboutscience. VoYS. If you feel this may be something for org/, a charitable trust with the main aim of you, or simply curious to know more, feel free ‘equipping people to make sense of science to browse the websites, contact the main office and evidence on issues that matter to society’. [email protected] or contact Images courtsey of Tom Donald They run a number of campaigns, such as Lindsay directly [email protected]
22 My week as a
Scientist by Robbie Dalgetty obbie is a work experience student from RBeeslack High School, Penicuik and he is working with the Institute Communications Group to learn more about public relations. Here he interviews a fellow work experience student. Look out for other articles from Robbie in this newsletter.
During my second week of work experience at The Roslin Institute, another High School student - Kirsty Lees - was taking part in a week long placement with the Scientists of The Roslin Institute. I sat down with Kirsty and asked her about her week as a Scientist.
Q) Why did you decide to come to The Roslin biology, Neurobiology and Neuropathogenesis, the reception they can go to or, they can just Institute to do your work experience? which have both been really cool. I have been turn round and look out to the Pentlands for a extracting and examining DNA from a Labrador moment of calm. I was really lucky actually! I knew I wanted to do and looking at it under a microscope. We something involving science, but last year when looked at different genes and then we looked at Q) How has the work made you feel? I was supposed to have my work experience, I astrocytes from a mouse brain and put them on Intelligent! I actually understand what I’m didn’t know anyone who could get me on such the computer in the bioimaging suit which was doing. There is a lot of overlap between this a placement. I found The Roslin Institute on the amazing. Also I’ve done a lot of walking up and and the studying I do in Biology, I just want database, kept the details of the placement and down stairs! to learn more and more! Some of the stuff I’m put in for it this year; luckily I got it! doing is very complicated, but not in a bad way, Q) Talking about walking around the building, instead of making me feel down because I don’t Q) You said you knew you wanted to something what do you think about it? understand it, it makes me more ambitious to with a scientific basis, is that with a particular learn about it. It has been a great experience. career in mind? It’s lovely, really beautiful. They have done a really good job with it. Everyone thinks of labs Q) Would you recommend coming here to other I have thought about various careers in and scientists in isolation and away in dark people and if so, who? science; Veterinary, GP, forensic scientist, but little rooms, and then you come here, with its I really have no idea yet! I know that I definitely massive, open plan labs and huge windows, it Defiantly, I would recommend it to everyone! want to go to university and study either Biology totally alters they way you think about science. Especially those who know they want to have or Chemistry, it sounds strange but Chemistry It isn’t really what I expected, I was thinking it a scientific career, but don’t yet know which really is my passion. would be really serious and plane, but it’s not! I science they want to do. The people here couldn’t believe how bright the place looks with are so friendly; they have given me so much Q) So what have you been learning over the the windows and brightly coloured walls. When advice and are so easy to get along with. They last week? I first came in to the reception area, I didn’t think have made me feel more like a worker than a I was in a research facility. student. I’ve learned so much! I had no idea how advanced the technology was. I’ve worked I explained to Kirsty how the designers of the Q) Finally, would you like to one day work here with machines and tools which are so cool, new Roslin Institute building where given a brief at Roslin Institute? and I had no idea they existed. I used to think to make the place as practical, interactive and that most of the experiments where done by co operative as possible. I asked her if she I would happily work here! I have loved every hand, but in actual fact they are carried out by thought the building achieved this brief, and if minute of it! I’m not sure just now which area these unbelievably clever machines. There is she thought it reflected the work done in The of science I want to study at university, but if I so much paper work too! A lot more than my Roslin Institute decided to do with Biology, and then yes Roslin classroom experiments at school, but I love would be a really brilliant place to work. it and everything I have done here has made Yes, defiantly! I love the open plan layout and realise just how much I want to do something the windows really make it a more attractive After her week at Roslin Institute, Kirsty returns like this as a career. place to work. I think it defiantly reflects the to school with a wider knowledge of the world work done here because the work is practically of science. She has a better idea of what she Q) What have you been doing this week? and in many cases artistic like in the bio wants to study at university, and hopes to imaging suit. I also think it helps the workers, one day become a PhD in either Biology or This week I have been focusing on two areas of if they get stressed out there is a lovely cafe in Chemistry.
23 Studying Overseas at The Roslin Institute by Robbie Dalgetty Wilfred had said he wanted to find something producing in a very short period results that I for her to get actively involved in; he did not will use alongside my own research was very want her to come over to stand and watch interesting. I am very pleased to have seen her other scientists do their research. So he and develop, get interested and find a direction in his team let her investigate which genes which to take her career.” control susceptibility or resistance in sheep to Magdalena gained a lot from her time in the a disease called scrapie. institute, but what she gave back is equally Magdalena wrote a report on her research, important. She gained experience working in and her results can be used by Wilfred in a a lab, and a report she submitted as part of future publication. The report she wrote gained her Bachelors degree, but the institute got a her the highest grade she could have achieved, student who understood what she was doing, an A+ and from what Wilfred could gather she and enjoyed it. must have been one of the first to hand in a Bachelors degree so early. In addition to her scientific success, she impressed Wilfred in Magdalena her approach to learning . “What I find interesting was her initiative, to n the summer months this year Dr Wilfred come to me and ask for an opportunity” IGoldmann took under his wing a Biology He could not express enough how good it Bachelors degree student from Vienna, was to see a student reaching out to others Magdalena Teufl. Magdalena sent a request to benefit herself. From working with her from to Wilfred asking if he would give her the July to September, and seeing what she is opportunity to do proper laboratory work, to capable of, Wilfred very confidently told me “I aid her degree. With Wilfred’s support and expect her to start a PhD” with her own funding Magdalena came to the What was particularly enjoyable for Wilfred institute and began work. PhD student Lauren was the teaching aspect Magdalena with Campbell and research assistant Paula Stewart “I like to teach, and watching Magdalena Goldman Lab collegues Paula from his group- gave Magdalena the laboratory develop from someone who has had very and Lauren experience she had requested. little experience in a lab, to someone who was
PG Student BBQ By Neil McDerment
hortly after the Official Opening of the Snew Roslin Institute Building the Roslin Postgraduate Social Committee held a more informal opening of its own, holding the first annual Postgraduate BBQ. It was the first major organisational challenge for the new committee which, although a trial by fire in more ways than one, was a great success. Despite competing with the Edinburgh Taste Festival, over a dozen research groups, including Scottish Agricultural College (SAC), were represented. The committee were pleased it was such a successful evening and it could not have happened without the support and participation of the students and post-docs who attended. We are especially thankful to those who brought the volleyball kit which distracted many of us from the disappointing tennis result! For those who unfortunately did not make it, hopefully we will see you at the next event. To find out more and for regular updates join us on Facebook at http://www.facebook.com/ home.php#!/groups/RPGSC
24 Recent Roslin Institute Publications
Acosta-Jamett, G., W. S. K. Chalmers, et al. stimulating factor 1 receptor (Csf1r, CD115) Eaglen, S. A., M. P. Coffey, et al. (2011). (2011). “Urban domestic dog populations as expression fails to discriminate dendritic cells “Phenotypic effects of calving ease on the a source of canine distemper virus for wild from macrophages.” Immunobiology 216(11): subsequent fertility and milk production of dam carnivores in the Coquimbo region of Chile.” 1228-1237. and calf in UK Holstein-Friesian heifers.” Journal Veterinary Microbiology 152(3-4): 247-257. of Dairy Science 94(11): 5413-23. Brown, K. L., A. Gossner, et al. (2011). “The Ali, M., P. M. Hocking, et al. (2011). “Mpdz Effects of Host Age on the Transport of Gates, H., A.-M. Mallon, et al. (2011). “High-throughput null allele in an avian model of retinal Complement-Bound Complexes to the Spleen mouse phenotyping.” Methods 53(4): 394-404. degeneration and mutations in human leber and the Pathogenesis of Intravenous Scrapie congenital amaurosis and retinitis pigmentosa.” Infection.” Journal of Virology E-pub 26 October. Gattegno-Ho, D., S. A. Argyle, et al. (2011). Investigative Ophthalmology & Visual Science “Stem cells and veterinary medicine: Tools 52(10): 7432-40. Brunton, P. J. and M. C. Holmes (2011). to understand disease and enable tissue “Stress, brains and bairns: Reviews from the 4th regeneration and drug discovery.” Veterinary Ashworth, C. J., C. M. Dwyer, et al. (2011). International Conference on the Parental Brain.” Journal E-pub 1 October. “Breed differences in fetal and placental Stress-the International Journal on the Biology of development and feto-maternal amino acid Stress 14(6): 577-580. Glass, E. J. and S. Crutchley (2011). “Living status following nutrient restriction during early with the enemy or univited guests: functional and mid pregnancy in Scottish Blackface and Buckley, L. A., P. M. Hocking, et al. (2011). genomics approaches to investigating host Suffolk sheep.” Reproduction, Fertility and “Can conditioned place preference be used resistance or tolerance traits to a protozoan Development 23(8): 1024-1033. to determine hungry broiler preferences for parasite in cattle.” Veterinary Immunology and qualitative or quantitative feed restriction?” British Immunopathology In Press. Ashworth, C. J., C. O. Hogg, et al. (2011). “Pre- Poultry Abstracts 7: 11-13. natal social stress and post-natal pain affect the Goldmann, W., K. Ryan, et al. (2011). “Caprine developing pig reproductive axis.” Reproduction Cabrera, C. P., I. C. Dunn, et al. (2011). prion gene polymorphisms are associated with E-pub 7 October. “Complex traits analysis of chicken growth using decreased incidence of classical scrapie in targeted genetical genomics.” Animal Genetics goat herds in the United Kingdom.” Veterinary Baillie, J. K., M. W. Barnett, et al. (2011). E-pub 7 July. Research 42(110). “Somatic retrotransposition alters the genetic landscape of the human brain.” Nature advance Caughey, S. D., S. M. Klampfl, et al. (2011). Gow, A. G., L. D. Fairbanks, et al. (2011). online publication. “Changes in the Intensity of Maternal Aggression “Xanthine urolithiasis in a Cavalier King Charles and Central Oxytocin and Vasopressin V1a spaniel.” Veterinary Record 169(8): 209. Banda, L. J., L. A. Kamwanja, et al. (2011). Receptors Across the Peripartum Period in the “Status of dairy cow management and fertility Rat.” Journal of Neuroendocrinology 23(11): Graham, J. F., D. Kurian, et al. (2011). “Na+/K+ in smallholder farms in Malawi.” Tropical Animal 1113-1124. -ATPase Is Present in Scrapie-Associated Fibrils, Health and Production In Press. Modulates PrP Misfolding
If you have any articles you would like to submit for the next Roslin Reporter, please contact: Patricia Hart, Scientific Administrator (email:[email protected] or phone: 0131 651 9192) or require imagery to accompany articles, please contact: Design and Print Department, The Roslin Institute (email:[email protected] or phone: 0131 651 9197)
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