MOLECULAR AND CELLULAR BIOLOGY

Volume 30 February 2010 No. 4

SPOTLIGHT

Articles of Significant Interest Selected from This Issue by 885 the Editors

MINIREVIEW Notch and the Skeleton Stefano Zanotti and Ernesto Canalis 886–896

ARTICLES Recruitment of the ESCRT Machinery to a Putative Seven- Antonio Herrador, Silvia Herranz, 897–907 Transmembrane-Domain Receptor Is Mediated by an David Lara, and Olivier Vincent Arrestin-Related mTORC1-Activated S6K1 Phosphorylates Rictor on Louis-Andre Julien, Audrey 908–921 Threonine 1135 and Regulates mTORC2 Signaling Carriere, Julie Moreau, and Philippe P. Roux MAGUK-Controlled Ubiquitination of CARMA1 Modulates Miguel E. Moreno-García, Karen 922–934 Lymphocyte NF-␬B Activity Sommer, Hisaaki Shinohara, Ashok D. Bandaranayake, Tomohiro Kurosaki, and David J. Rawlings Structure-Specific Recognition Protein 1 Facilitates Shelya X. Zeng, Yanping Li, Yetao 935–947 Microtubule Growth and Bundling Required for Mitosis Jin, Qi Zhang, David M. Keller, Carolyn M. McQuaw, Eric Barklis, Stacie Stone, Maureen Hoatlin, Yingming Zhao, and Hua Lu

AG1 Checkpoint Mediated by the Retinoblastoma Protein Srikanth Talluri, Christian E. Isaac, 948–960 That Is Dispensable in Terminal Differentiation but Mohammad Ahmad, Shauna A. Essential for Senescence Henley, Sarah M. Francis, Alison L. Martens, Rod Bremner, and Frederick A. Dick Structural Insights into Nox4 and Nox2: Motifs Involved in Katharina von Lo¨hneysen, Deborah 961–975 Function and Cellular Localization Noack, Malcolm R. Wood, Jeffrey S. Friedman, and Ulla G. Knaus The Final Step in 5.8S rRNA Processing Is Cytoplasmic in Emma Thomson and David 976–984 Tollervey The Ubiquitin Ligase Hul5 Promotes Proteasomal Sharon Aviram and Daniel 985–994 Processivity Kornitzer The Caenorhabditis elegans Ste20-Related Kinase and Rac- Kota Fujiki, Tomoaki Mizuno, 995–1003 Type Small GTPase Regulate the c-Jun N-Terminal Kinase Naoki Hisamoto, and Kunihiro Signaling Pathway Mediating the Stress Response Matsumoto Formation of the Redox Cofactor Centers during Cox1 Oleh Khalimonchuk, Megan 1004–1017 Maturation in Yeast Cytochrome Oxidase Bestwick, Brigitte Meunier, Talina C. Watts, and Dennis R. Winge Selective Signaling by Akt2 Promotes Bone Morphogenetic Aditi Mukherjee, Elizabeth M. 1018–1027 Protein 2-Mediated Osteoblast Differentiation Wilson, and Peter Rotwein Frequency-Dependent Regulation of Follicle-Stimulating Nick A. Ciccone, Shuyun Xu, 1028–1040 Hormone ␤ by Pulsatile Gonadotropin-Releasing Hormone Charlemagne T. Lacza, Rona S. Is Mediated by Functional Antagonism of bZIP Carroll, and Ursula B. Kaiser Transcription Factors Pirh2 E3 Ubiquitin Ligase Targets DNA Eta for Yong-Sam Jung, Gang Liu, and 1041–1048 20S Proteasomal Degradation Xinbin Chen

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Tor Directly Controls the Atg1 Kinase Complex To Regulate Yoshiaki Kamada, Ken-ichi 1049–1058 Autophagy Yoshino, Chika Kondo, Tomoko Kawamata, Noriko Oshiro, Kazuyoshi Yonezawa, and Yoshinori Ohsumi Telomere Protection by TPP1 Is Mediated by POT1a and Tatsuya Kibe, Gail A. Osawa, 1059–1066 POT1b Catherine E. Keegan, and Titia de Lange Modulation of Chromatin Boundary Activities by Mo Li, Vladimir E. Belozerov, and 1067–1076 Nucleosome-Remodeling Activities in Drosophila melanogaster Haini N. Cai Rab13 Regulates Neurite Outgrowth in PC12 Cells through Ayuko Sakane, Kazufumi Honda, 1077–1087 Its Effector Protein, JRAB/MICAL-L2 and Takuya Sasaki DNA Polymerase POLN Participates in Cross-Link Repair George-Lucian Moldovan, Mahesh 1088–1096 and Homologous Recombination V. Madhavan, Kanchan D. Mirchandani, Ryan M. McCaffrey, Patrizia Vinciguerra, and Alan D. D’Andrea NAD(P)H Quinone-Oxydoreductase 1 Protects Eukaryotic Amandine Alard, Bertrand Fabre, 1097–1105 Translation Initiation Factor 4GI from Degradation by the Rodica Anesia, Catherine Proteasome Marboeuf, Philippe Pierre, Christiane Susini, Corinne Bousquet, and Ste´phane Pyronnet

ERRATUM Regulation of G-Protein Signaling by RKTG via Yuhui Jiang, Xiaoduo Xic, Yixuan 1106 Sequestration of the G␤␥ Subunit to the Golgi Apparatus Zhang, Xiaolin Luo, Xiao Wang, Fengjuan Fan, Dawei Zheng, Zhenzhen Wang, and Yan Chen

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Loss of cytochrome P450 oxidoreductase in the developing mouse limb leads to fusion of joints postnatally as shown in a fast green/safranin O-stained section of an interphalangeal joint of a 3-week-old conditional knockout mouse. (See related article in May 2009, vol. 29, no. 10, p. 2716.)