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INT 0190 Title: Interview with Morton Davidson, MD by Nicholas Webb Date: March 20, 2017 Copyright: Icahn School of Medicine at Mount Sinai
Call #: INT 0190 Title: Interview with Morton Davidson, MD by Nicholas Webb Date: March 20, 2017 Copyright: Icahn School of Medicine at Mount Sinai The Arthur H. Aufses, Jr. MD Archives This document is a transcript of an oral history interview from the collections of The Arthur H. Aufses, Jr. MD Archives. This material is provided to users in order to facilitate research and lessen wear on the original documents. It is made available solely for the personal use of individual researchers. Copies may not be transferred to another individual or organization, deposited at another institution, or reduplicated without prior written permission of the Aufses Archives. Provision of these archival materials in no way transfers either copyright or property right, nor does it constitute permission to publish in excess of "fair use" or to display materials. For questions concerning this document, please contact the Aufses Archives: The Arthur H. Aufses, Jr. MD Archives Box 1102 One Gustave L. Levy Place New York, NY 10029-6574 (212) 241-7239 [email protected] INT 0190 DAVIDSON 2 Interview 0190 with Morton Davidson, MD by Nicholas Webb Mount Sinai Health System Oral History Archive By telephone, March 20, 2017 MORTON DAVIDSON: Hello. NICHOLAS WEBB: Hi. Dr. Davidson? DAVIDSON: Yes! WEBB: Hi! This is Nicholas Webb from the Mount Sinai Archives. DAVIDSON: Oh, hi. A little earlier than I thought. Okay. WEBB: Yes. It’s still a good time to talk? DAVIDSON: Yeah, I’m going to walk inside and do that. Hold on, just one second. WEBB: Yeah. [Pause] DAVIDSON: I was doing my [unclear]. -
White Book on IBD Research
White Book on IBD Research Roadmap on IBD research grants funded by IBD patient associations Front cover: Radoslaw Ptak/Emily Brochocka from the Polish IBD awareness raising campaign “WC out – coming out from the toilet”. Every effort has been made to ensure that the information in this publication is presented accurately. The contents are provided for general information and should not be relied upon for any specific purpose. Descriptions of, or references to, products or publications do not imply endorsement of that product or publication. Patients should consult their doctors if they have any medical concerns. Neither the Officers of the Executive Committee nor the editor can be held responsible for errors or for any other consequences arising from the use of information contained herein. Al rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission of the EFCCA Secretary. 1 TABLE OF CONTENTS 1. INTRODUCTION 3 2. SETTING THE SCENE 4 3. COMPILATION OF IBD RESEARCH PROJECTS FUNDED BY IBD PATIENT ASSOCIATIONS 6 3.1 Argentina 6 3.2 Australia 6 3.3 Belgium, CCV 7 3.4 Belgium, RCUH 8 3.5 Canada 9 3.6 Denmark 11 3.7 Finland 12 3.8 France 12 3.9 Germany 13 3.10 Ireland 15 3.11 Italy 15 3.12 Israel 20 3.13 The Netherlands 21 3.14 Sweden 21 3.15 Switzerland 22 3.16 The United Kingdom 23 3.17 The United States 30 4. IBD RESEARCH FOUNDATION 35 5. -
Randomized, Double Blind, Prospective Trial Investigating The
Randomized, double blind, prospective trial investigating the efficacy of Methotrexate in induction and maintenance of steroid free remission in ulcerative colitis (MEthotrexate Response In Treatment of UC - MERIT-UC) Protocol Version 1.9, July 1, 2014 Sponsor/Principal Investigator: Hans H. Herfarth, MD, PhD Division of Gastroenterology and Hepatology University of North Carolina Phone:919-966-6806 Fax: 919-966-7592 email: [email protected] Co-Investigators: Kim Isaacs, MD, PhD Division of Gastroenterology and Hepatology University of North Carolina James Lewis, MD, MSCE Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Mark Osterman, MD Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Bruce Sands, MD, MS Dr. Henry Janowitz Division of Gastroenterology The Mount Sinai Medical Center, New York Biostatistician Anastasia Ivanova, PhD Gillings School of Global Public Health University of North Carolina at Chapel Hill Lead Study Coordinator Susan Jackson Division of Gastroenterology and Hepatology University of North Carolina Phone: 919-843-9071 Fax: 919-843-6633 Email: [email protected] Data Management Center Center of Gastrointestinal Biology and Disease Biostatistics Core University of North Carolina Christopher Martin Phone: 919-966-9340Fax: 919-966-7592 Email: [email protected] Funding Agent National Institutes of Health (NIH) Methotrexate response in treatment of UC 1 SUMMARY 4 2 INTRODUCTION AND BACKGROUND 10 Clinical pharmacology of MTX 10 Effectiveness of MTX in -
Statistical Analysis Plan
Randomized, double blind, prospective trial investigating the efficacy of Methotrexate in induction and maintenance of steroid free remission in ulcerative colitis (MEthotrexate Response In Treatment of UC - Merit-UC) DATA ANALYSIS PLAN Version 1.4 5/30/2015 Anastasia Ivanova, PhD Gillings School of Global Public Health University of North Carolina at Chapel Hill Christopher F. Martin, MSPH Center of Gastrointestinal Biology and Disease Biostatistics Core University of North Carolina Principal Investigator: Hans H. Herfarth, MD, PhD Division of Gastroenterology and Hepatology University of North Carolina Co-Investigators: Kim Isaacs, MD, PhD Division of Gastroenterology and Hepatology University of North Carolina James Lewis, MD, MSCE Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Mark Osterman, MD Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Bruce Sands, MD, MS Dr. Henry Janowitz Division of Gastroenterology The Mount Sinai Medical Center, New York 1 1 STATISTICAL ANALYSIS 3 1.1 ANALYSIS OF INDUCTION PHASE REMISSION RATES 3 1.2 PRIMARY ANALYSES 4 1.3 DEFINITION OF PRIMARY AND SECONDARY OUTCOMES 4 1.4 PATIENT CHARACTERISTICS OF INTEREST 5 2 ANALYSIS PLAN 5 2.1 DESCRIPTIVE STATISTICS 5 2.2 ANALYSIS OF PRIMARY AND SECONDARY OUTCOMES 6 2.3 EXPLORATORY ANALYSES OF FACTORS ASSOCIATED WITH REMISSION 6 2.4 EXPLORATORY ANALYSES OF FACTORS ASSOCIATED WITH SUCCESSFUL INDUCTION THERAPY 7 3 DSMB INTERIM ANALYSES AND EARLY STOPPING RULES FOR INTERIM ANALYSES 7 4 REFERENCES 8 2 The statistical analyses of the primary and secondary endpoints will be performed with the statistical support of Joseph Galanko, PhD, who is the biostatistician at the Biostatistics Core of the Center for Gastrointestinal Biology and Disease at the University of North Carolina and Christopher Martin, MSPH, who is the director of the Biostatistics Core of the Center for Gastrointestinal Biology and Disease at the University of North Carolina. -
Crohn's Disease
Part II Crohn's disease ORIGINS Inflammatory bowel disease descriptively consistent with Crohn's disease apparently was observed three hundred years ago, possibly earlier in Carson's "Iliac Passion.,,279 Wilhelm Fabry280 (Guilhelmus Fabricius Hildanus) of Hilden-Cologne, Germany (1560-1629), had noted at autopsy in a boy who had experienced persistent "subhepatic pain" that "the cecum (was) contracted and invaginated into the ileum ... such that it was not possible for anything to pass from the proximal intestine into the colon." On extracting the cecum, it was ulcerated and fibrous. J.H. Baron,281 in a review of early instances of possible Crohn's disease, cites J.J. Bernier et al. 282 on La Maladie de Louis XIII. Baron writes "... Louis XIII is known to have been prone to attacks of diarrhea for decades, associated with fever and a rectal abscess that discharged spontaneously. In 1642, he experienced bloody diarrhea, fever, abdominal pain and a perianal abscess or fistula. He died the following year, at age 42. Autopsy revealed ulcerations of small and large bowel, with abscesses and fistulas, compatible with ileocecal tuberculosis or regional enteritis." The noted pathologist G.B. Morgagni283 of Forli. Italy (1682-177l) in his "De Sedibus et Causis Morborum" in 1761, described ulcerations and perfora tion of an inflamed. narrowed distal ileum and enlarged mesenteric lymph nodes in a young man of 20 with a history of diarrhea and fever culminating in death after 14 days. C. Combe and W. Saunders284 (1813) of England. reporting a patient who had experienced abdominal cramps and diarrhea. wrote: "The lower part of the ileum as far as the colon was ulcerated and contracted for three feet to the size of a turkey quill." J.