Anti-Clcn4 [N222/6] Bulk Size, 1 Mg, Ab02155-10.3-BT View Online

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Anti-Clcn4 [N222/6] Bulk Size Ab02155-10.3-BT

This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Isotype and Format: Human IgG1, Fc Silent™, Kappa Clone Number: N222/6 Alternative Name(s) of Target: N222/6R; H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4 UniProt Accession Number of Target Protein: P51793 Published Application(s): ICC, WB, IHC Published Species Reactivity: Rat, Human, Mouse Immunogen: This antibody was raised by immunising BALB/c mice with a synthetic peptide amino acids 30-51 (TDRHRKITSKSKESIWEFIKSL, cytoplasmic N-terminus) of rat Clcn4. Specificity: This antibody is specific for the CLCN4 protein. It does not cross react with CLCN5. CLCN4 is a strongly outwardly rectifying, electrogenic H+/Cl-exchanger which mediates the exchange of chloride ions against protons. Application Notes: This antibody could be useful for immunocytochemistry, immunohistochemistry and western blot Antibody First Published in: Andrews et al. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain eLife. 2019; 8: e43322. PMID:30667360 Note on publication: This article describes the generation of a library of recombinant monoclonal antibodies (R-mAbs) from a pool of mAb-producing hybridomas for neuroscience research.

Product Form

Size: 1 mg Purified antibody in bulk size. Purification: Protein A affinity purified Supplied In: PBS only. Storage Recommendation: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer

Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.