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Cold Spring Harbor Symposia on Quantitative Biology COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LIX COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LIX The Molecular Genetics of Cancer COLD SPRING HARBOR LABORATORY PRESS 1994 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LIX 1994 by The Cold Spring Harbor Laboratory Press International Standard Book Number 0-87969-067-4 (cloth) International Standard Book Number 0-87969-068-2 (paper) International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena XXVIlI (1963) Synthesis and Structure of Macromolecules II (1934) Aspects of Growth XXIX (1964) Human Genetics III (1935) Photochemical Reactions XXX (1965) Sensory Receptors IV (1936) Excitation Phenomena XXXI (1966) The Genetic Code V (1937) Internal Secretions XXXII (1967) Antibodies VI (1938) Protein Chemistry XXXIII (1968) Replication of DNA in Microorganisms VII (1939) Biological Oxidations XXXIV (1969) The Mechanism of Protein Synthesis VII1 (1940) Permeability and the Nature of Cell Membranes XXXV (1970) Transcription of Genetic Material IX (1941) Genes and Chromosomes: Structure and Organiza- XXXVI (1971) Structure and Function of Proteins at the tion Three-dimensional Level X (1942) The Relation of Hormones to Development XXXVII (1972) The Mechanism of Muscle Contraction XI (1946) Heredity and Variation in Microorganisms XXXVIII (1973) Chromosome Structure and Function XII (1947) Nucleic Acids and Nucleoproteins XXXIX (1974) Tumor Viruses XIII (1948) Biological Applications of Tracer Elements XL (1975) The Synapse XIV (1949) Amino Acids and Proteins XLI (1976) Origins of Lymphocyte Diversity XV (1950) Origin and Evolution of Man XLII (1977) Chromatin XVI (1951) Genes and Mutations XLIII (1978) DNA: Replication and Recombination XVII (1952) The Neuron XLIV (1979) Viral Oncogenes XVIII (1953) Viruses XLV (1980) Movable Genetic Elements XIX (1954) The Mammalian Fetus: Physiological Aspects of XLVI (1981) Organization of the Cytoplasm Development XLVII (1982) Structures of DNA XX (1955) Population Genetics: The Nature and Causes of XLVIII (1983) Molecular Neurobiology Genetic Variability in Population XLIX (1984) Recombination at the DNA Level XXI (1956) Genetic Mechanisms: Structure and Function L (1985) Molecular Biology of Development XXll (1957) Population Studies: Animal Ecology and De- LI (1986) Molecular Biology of Homo sapiens mography LII (1987) Evolution of Catalytic Function XXIII (1958) Exchange of Genetic Material: Mechanism and LIII (1988) Molecular Biology of Signal Transduction Consequences LIV (1989) Immunological Recognition XXIV (1959) Genetics and Twentieth Century Darwinism LV (1990) The Brain XXV (1960) Biological Clocks LVI (1991) The Celt Cycle XXVI (1961) Cellular Regulatory Mechanisms LVII (1992) The Cell Surface XXVII (1962) Basic Mechanisms in Animal Virus Biology LVIII (1993) DNA and Chromosomes Front Cover (Paperback): Retinoblastoma protein forms "corrals" in the nucleus. (For details, see W.-H. Lee et al., p. 103, this volume.) Back Cover (Paperback): H & E staining and immunohistochemical staining with antibodies against von Willebrand factor of lungs of mice after removal of the primary tumor. (For details, see O'Reilly et al., p. 479, this volume.) Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Cold Spring Harbor Laboratory for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $5.00 per article is paid directly to CCC, 222 Rosewood Dr., Danvers, MA 01923. [0-87969-067-4/94 $5.00 + .00]. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. All Cold Spring Harbor Laboratory Press publications may be ordered directly from Cold Spring Harbor Laboratory Press, 10 Skyline Drive, Plainview, NY 11803. Phone: 1-800-843-4388 in Continental U.S. and Canada. All other locations (516)349-1930. FAX: (516)349-1946. Symposium Participants ABEL, KENNETH,Dept. of Internal Medicine, Uni- England Medical Center, Boston, Massachu- versity of Michigan, Ann Arbor setts ADYA, NEERAJ, Dept. of Infectious Diseases, Case BARKARDOTTIR, ROSA, Dept. of Pathology and Western Reserve University School of Medi- Cell Biology, University Hospital of Iceland, cine, Cleveland, Ohio Reykjavik AGARWAL, MUNNA, Dept. of Molecular Biology, BARNES, DEBORAH, Journal of NIH Research, Cleveland Clinic Foundation, Cleveland, Washington, D.C. Ohio BARRETT, J. CARL, Lab. of Molecular Carcino- ALBERTS, BRUCE, Dept. of Biochemistry and Bio- genesis, NIH-National Institute of Environ- physics, University of California, San Fran- mental Health Sciences, Research Triangle cisco Park, North Carolina AMARIGLIO, NINET37E, Institute of Hematology, BARTEK, JIRI, Danish Cancer Society, Copen- Chaim Sheba Medical Center, Tel Hash- hagen, Denmark omer, Israel BASlLE, THOMAS, Chadbourne and Parke, New AMFO, KWASI HENRY, Dept. of Medical Genetics, York, New York Free University of Brussels, Belgium BEACH, DAVID, Cold Spring Harbor Laboratory, ANDERS, ROBERT, Dept. of Biochemistry, Mayo Cold Spring Harbor, New York Clinic, Rochester, Minnesota BENFIELD, PAM, Dept. of Molecular Biology, Du ANDO, KIYOSHI,Tokai University School of Med- Pont Merck Pharmaceutical Co., Wilming- icine, Kanagawa, Japan ton, Delaware BENZOW, KELLIE,Virginia Piper Cancer Institute, ANDRULIS, IRENE, Dept. of Molecular and Medi- Abbott Northwestern Hospital, Minne- cal Genetics, Samuel Lunenfeld Research apolis, Minnesota Institute, Mount Sinai Hospital, Toronto, BEPLER, GEROLD, Dept. of Medicine and Molecu- Ontario, Canada lar Cancer Biology, Duke University Medical APLAN, PETER, Dept. of Pediatrics and Molecular Center, Durham, North Carolina Medicine, Roswell Park Cancer Institute, BERNDT, NORBERT, Dept. of Pediatrics, Childrens Buffalo, New York Hospital of Los Angeles, California ARASON, ADALGEIR, Dept. of Pathology and Cell BERNS, ANTON, Dept. of Molecular Genetics, The Biology, University Hospital of Iceland, Netherlands Cancer Institute, Amsterdam Reykjavik BI, WANLI, Dept. of Anatomy and Cell Biology, ARIGA, HIROYOSHI, Dept. of Molecular Biology, University of Cincinnati, Ohio Hokkaido University, Sapporo, Japan BIRAN, HAIM, Familial Cancer Program, Sheibe AURIGEMMA, ROSEMARIE, Dept. of Molecular Institute of Oncology, Kaplan Hospital, Re- Oncology, National Cancer Institute, Fred- hovot, Israel erick Cancer Research Facility, Frederick, BISHOP, J. MICHAEL, Dept. of Microbiology, Uni- Maryland versity of California, San Francisco AXELROD, AMY, Cell, Cambridge, Massachusetts BEACH, JAROMIR, Swiss Institute for Experimental AYTAY, SAIKA, Applied Genetics Laboratories, Cancer Research, Epalinges, Lausanne, Swit- Melbourne, Florida zerland BADE, ERNESTO, Dept. of Biology, University of BLAESE, MICHAEL, Dept. of Cell Immunology, Konstanz, Konstanz, Germany National Institutes of Health, Bethesda, BALMAIN, ALLAN, Dept. of Medical Oncology, Maryland Beatson Institute for Cancer Research, Glas- BLOOM, THEODORA, Current Biology, London, gow, Scotland, United Kingdom United Kingdom BAND,VIMLA, Dept. of Radiation Oncology, New BODRUG, SHARON,Div. of Oncogene and Tumor vi SYMPOSIUM PARTICIPANTS Suppressor Gene Research, La Jolla Re- land Clinic Research Institute, Cleveland, search Foundation, La Jolla, California Ohio BOISE, LAWRENCE,Howard Hughes Medical Insti- CASTILLA, LUCIO, Dept. of Biology, University of tute, University of Chicago, Chicago, Illinois Michigan, Ann Arbor BOON, THIERRV, Ludwig Institute for Cancer Re- CERNI, CHRISTA, Dept. of Tumor Virology, Insti- search, Brussels, Belgium tute of Tumorbiology and Cancer Research, BORG,/~KE, Dept. of Oncology, University Hospi- University of Vienna, Austria tal, Lurid, Sweden CHAGNOVICH, DANIEL, Robert H. Lurie Cancer BOSSELUT, REMu Lab. of Viral and Cellular On- Center, Northwestern University, Chicago, cology, Institut Curie-Biology, Centre Uni- Illinois versitaire, Orsay, France CHANG, HENRY, Dept. of Molecular and Cell BOUCK, NOEL, Dept. of Microbiology and Immu- Biology, University of California, Berkeley nology, Northwestern University, Chicago, CHANG, KAI-HSUAN, Institute of Biotechnology, Illinois University of Texas Health Sciences Center, BOYLAN, JOHN, Du Pont Merck Pharmaceutical San Antonio Co., Wilmington, Delaware CHANG, SHENC-YUNG, Roche Molecular Systems, Alameda, California BRASH, DOUGLAS,Lab. of Radiobiology, Yale Uni- versity School of Medicine, New Haven, CHANG, ZEE-FEN, Dept. of Biochemistry, Chang Gung Medical College, Tao-Yuan, Taiwan Connecticut CHAPMAN, CAROLINE, Beatson Institute for Can- BRENNER, MALCOLM, Dept. of Bone Marrow cer Research, Glasgow, Scotland, United Transplantation, St. Jude Children's Re- Kingdom search Hospital, Memphis, Tennessee CHAY, CHRISTOPHER, Lab. of Human Carcino- Dept. of Biology, Massachu- BRISKEN, CATHERINE, genesis, National Cancer Institute, National setts Institute of Technology, Whitehead In- Institutes of Health, Bethesda, Maryland stitute for Biomedical Research, Cambridge, CHEN, CHANG-YAN, Cancer Research Center, Massachusetts Boston University School of Medicine, Bos- BROK-SIMONI, FRIDA, Institute
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