Supplementary Table 19. Pathway enrichment analysis (IPA pathways) for genes differentially expressed in histologically normal (LTG) and tumor (TCGA, PAAD) derived pancreatic tissue samples. Canonical Pathways -log(P-value) Ratio* Genes in pathway Atherosclerosis Signaling 4.65 0.21 PLA2G16,ALOX12B,IL1A,LPA,MMP3,PLA2G10,CD36,PLA2G1B,CXCL12,COL10A1,ALOXE3,SELPLG,APOL1,IL18,ALB,LYZ,ORM1,IL1RN,APOC1,RARRES3,PNPLA3,SERPINA1,PLA2G4F,PDGFD,MMP1,PLA2G12A Agranulocyte Adhesion and Diapedesis 4.38 0.18 IL1A,MMP7,FN1,MMP3,MMP14,CXCL12,CCL20,CCL17,CCL22,CXCL5,HRH1,ITGA3,CLDN4,EZR,CXCL14,MMP11,MMP12,CCL15,MMP1,MMP28,ACTB,MYH14,CLDN18,ITGA2,CKLF,MMP10,MYH7,SELPLG,C5,IL18,CLDN23,IL1RN,CLDN2,CCL26 Bladder Cancer Signaling 4.31 0.23 CDKN2A,MMP7,MMP3,MMP28,RRAS,MMP14,EGF,MMP10,MYC,FGF17,FGFR3,FGF10,MAPK3,FGF12,E2F1,FGF20,MMP11,MMP12,MMP1,FGF19 Granulocyte Adhesion and Diapedesis 4.21 0.18 IL1A,MMP7,MMP3,MMP14,CXCL12,CCL20,CCL17,CCL22,CXCL5,IL1R2,HRH1,ITGA3,CLDN4,EZR,CXCL14,MMP11,MMP12,CCL15,MMP1,SDC1,MMP28,CLDN18,ITGA2,CKLF,MMP10,SELPLG,C5,IL18,CLDN23,IL1RN,CLDN2,CCL26 Glycolysis I 3.78 0.36 ENO1,PKM,ENO2,ALDOA,GAPDH,PGAM4,PFKP,ALDOC,FBP2 SHH,RAC2,BMP4,UNC5B,CXCL12,ADAM8,PLCD3,ITGA3,SEMA6D,PLCE1,GNA15,ECE2,ADAM28,MAPK3,WNT7B,ABLIM3,BAIAP2,PLCB1,TUBA1C,GDF7,TUBB3,CFL1,RRAS,FZD9,MET,PLCB3,PAK7,PDGFD,EPHA2,ADAMTS7,MMP7,ARPC1B,EGF,EPHA4,PLXNA2,WNT8B,WNT2,EFNB2,WNT7A,EPHA8,MYSM1,GLIS1,EFNA5,EFNB Axonal Guidance Signaling 3.57 0.14 1,MKNK1,ADAM19,MMP11,VASP,NRP2,ITGA2,TUBA4A,EFNA3,MMP10,EFNA4,PRKAR2B,NTRK2,WNT10A,PAK3,BMP7,SEMA7A Cell Cycle: G2/M DNA Damage Checkpoint Regulation 3.07 0.25 CDKN2A,CDC25C,KAT2B,CKS2,CKS1B,TOP2A,CCNB2,PKMYT1,PLK1,SFN,CDK1,CCNB1 Regulation of Cellular Mechanics by Calpain Protease 2.97 0.23 CAPN5,CCNA2,CAPN8,CCNE1,ITGA3,RRAS,MAPK3,EZR,ACTN2,ITGA2,EGF,CAPN9,CDK1 Aryl Hydrocarbon Receptor Signaling 2.97 0.17 CDKN2A,GSTA2,IL1A,NFIC,TFF1,GSTA4,NQO1,BAX,RARG,MYC,TGM2,CCNA2,CCNE1,ALDH1A1,GSTM2,ALDH1L2,MAPK3,E2F1,GSTA1,ALDH3B1,ALDH3B2,ALDH3A1,GSTP1,ALDH6A1 Mitotic Roles of Polo-Like Kinase 2.83 0.21 KIF23,CDC25C,ESPL1,CDC20,PTTG1,PRC1,CCNB2,PLK1,CDK1,CCNB1,PKMYT1,PPP2R2C,PPP2R1B,KIF11 Inhibition of Matrix Metalloproteases 2.81 0.26 MMP7,SDC1,MMP28,MMP3,TIMP1,MMP14,MMP10,MMP11,MMP12,MMP1 Acetone Degradation I (to Methylglyoxal) 2.78 0.30 FAM213B,CYP2E1,CYP2C18,CYP2C9,CYP2J2,CYP2B6,CYP2S1,CYP2C19 Glioblastoma Multiforme Signaling 2.71 0.16 CDKN2A,RHOC,RRAS,DIRAS3,EGF,FZD9,WNT8B,WNT2,MYC,PLCD3,CCNE1,WNT7A,PLCE1,WNT10A,WNT7B,MAPK3,E2F1,ITPR3,PLCB3,PLCB1,LEF1,PDGFD,RHOF,E2F2 Coagulation System 2.59 0.26 F11,F12,F8,F5,PROC,PLAUR,SERPINA1,PLAU,PLAT LPS/IL-1 Mediated Inhibition of RXR Function 2.55 0.15 IL1A,CYP2C9,HS3ST3A1,CYP2C19,IL1R2,GSTM2,ALDH1A1,UST,NR1I2,ACSL5,HS6ST2,HS3ST1,HS6ST3,GSTA1,ALDH3A1,ALDH6A1,GSTA2,SULT1C2,GSTA4,ACSL6,SULT2B1,IL18,SULT1E1,ALDH1L2,IL1RN,APOC1,NR5A2,ALDH3B1,CYP2B6,ALDH3B2,SULT1B1,GSTP1 Eicosanoid Signaling 2.49 0.20 PLA2G16,PTGES,ALOX12B,DPEP1,AKR1C3,PTGER3,PLA2G10,PLA2G1B,RARRES3,PNPLA3,PLA2G4F,PTGER4,PLA2G12A Bupropion Degradation 2.34 0.28 CYP2E1,CYP2C18,CYP2C9,CYP2J2,CYP2B6,CYP2S1,CYP2C19 Gluconeogenesis I 2.34 0.28 ENO1,ENO2,ALDOA,GAPDH,PGAM4,ALDOC,FBP2 Actin Cytoskeleton Signaling 2.34 0.14 RAC2,FN1,ARPC1B,DIAPH3,MYLK2,PIKFYVE,EGF,SLC9A1,ITGA3,FGF10,EZR,MAPK3,BAIAP2,FGF12,TMSB10/TMSB4X,IQGAP3,FGF19,CFL1,RRAS,ACTB,ACTN2,MYH14,ITGA2,MYH7,TTN,FGF17,PAK3,VAV3,FGF20,PAK7,PDGFD PXR/RXR Activation 2.31 0.19 GSTA2,PRKAR2B,ALDH1A1,GSTM2,NR1I2,FOXO3,CYP2C9,GSTA1,INSR,CYP2B6,IGFBP1,UGT1A7 (includes others),CYP2C19 Synaptic Long Term Depression 2.22 0.16 PLA2G16,NOS1,GUCY2C,RRAS,GRIA1,PLA2G10,RYR2,PLA2G1B,GRM5,PLCD3,PLCE1,GNA15,MAPK3,ITPR3,PLCB3,PLCB1,RARRES3,PPP2R2C,PLA2G4F,PNPLA3,PPP2R1B,PLA2G12A β-alanine Degradation I 2.12 1.00 ABAT,ALDH6A1 Glycine Degradation (Creatine Biosynthesis) 2.12 1.00 GAMT,GATM Cysteine Biosynthesis/Homocysteine Degradation 2.12 1.00 CBS/CBSL,CTH Caveolar-mediated Endocytosis Signaling 2.09 0.18 ITGA3,CD55,ALB,ITGA11,HLA-A,ACTB,HLA-B,ITGA2,EGF,INSR,ITGB4,ITGB6,ITGB5 Cellular Effects of Sildenafil (Viagra) 2.07 0.16 KCNN4,PDE4C,GUCY2C,CACNG4,ACTB,MYH14,SLC4A11,PDE3A,MYH7,KCNN2,PDE1C,PLCD3,PLCE1,PRKAR2B,PDE3B,PABPC4,ADCY1,ITPR3,PLCB3,PLCB1 Sperm Motility 2.05 0.16 PLA2G16,SLC16A10,PDE4C,PLA2G10,PLA2G1B,PDE1C,PLCD3,PRKAR2B,PLCE1,ITPR3,PTK6,PLCB3,PLCB1,RARRES3,PLA2G4F,PNPLA3,MST1R,CATSPER1,PLA2G12A Triacylglycerol Biosynthesis 2.03 0.23 PPAPDC1A,PPAPDC1B,PPP2R2D,LPCAT4,ELOVL2,MBOAT2,PPAP2C,ELOVL6 Methylglyoxal Degradation III 2.01 0.31 AKR7A3,FAM213B,AKR1C3,CYP2E1,AKR1B10 Intrinsic Prothrombin Activation Pathway 1.96 0.24 F11,F12,F8,F5,PROC,COL10A1,KLK1 Phospholipases 1.96 0.19 PLA2G16,PLCD3,PLCE1,PLA2G10,PLA2G1B,RARRES3,PLCB1,PLCB3,PLA2G4F,PNPLA3,PLA2G12A Interferon Signaling 1.95 0.22 OAS1,MX1,IFI35,IFI6,PSMB8,BAX,IFITM1,ISG15 Dermatan Sulfate Biosynthesis (Late Stages) 1.90 0.21 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 Xenobiotic Metabolism Signaling 1.89 0.13 IL1A,CAMK1D,UGT1A6,CYP2C9,HS3ST3A1,CYP2C19,GSTM2,ALDH1A1,UST,NR1I2,MAPK3,HS6ST2,PPP2R2C,HS3ST1,HS6ST3,GSTA1,ALDH3A1,CITED2,ALDH6A1,GSTA2,SULT1C2,RRAS,GSTA4,NQO1,SULT2B1,SULT1E1,ALDH1L2,ALDH3B1,CYP2B6,ALDH3B2,PPP2R1B,EIF2AK3,UGT1A7 (includes others),GSTP1,SULT1B1 Antigen Presentation Pathway 1.88 0.22 HLA-G,PSMB9,HLA-DQB2,HLA-A,HLA-B,PSMB8,HLA-F,TAPBP Estrogen-mediated S-phase Entry 1.82 0.25 MYC,CCNA2,CCNE1,E2F1,CDK1,E2F2 Triacylglycerol Degradation 1.82 0.25 PNLIPRP2,CEL,PNLIPRP1,MGLL,PNPLA3,PNLIP Estrogen Biosynthesis 1.81 0.21 AKR1C3,CYP2E1,CYP2C18,CYP2C9,CYP2J2,CYP2B6,CYP2S1,CYP2C19 Agrin Interactions at Neuromuscular Junction 1.80 0.17 RAC2,ITGA3,NRG2,PAK3,NRG3,RRAS,ERBB4,MAPK3,ACTB,ITGA2,NRG4,PAK7 Chondroitin Sulfate Biosynthesis (Late Stages) 1.77 0.20 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 Nicotine Degradation III 1.76 0.19 UGT1A6,CYP2E1,CYP2C18,CYP2C9,CYP2J2,AOX1,CYP2B6,UGT1A7 (includes others),CYP2S1,CYP2C19 Unfolded protein response 1.76 0.19 PPARG,SEL1L,PDIA2,P4HB,ERN1,ERO1B,XBP1,CD82,DNAJB9,EIF2AK3 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell 1.71 0.17 PLCD3,GRPR,PLCE1,PRKAR2B,GNA15,GLP1R,ADCY1,ITPR3,PLCB1,PLCB3,GRP,CCK Fatty Acid α-oxidation 1.68 0.26 ALOX12B,ALDH1A1,ALDH3B1,ALDH3A1,ALOXE3 DNA damage-induced 14-3-3σ Signaling 1.68 0.26 CCNE1,CCNB2,SFN,CDK1,CCNB1 S-adenosyl-L-methionine Biosynthesis 1.66 0.67 MAT1A,MAT2A Retinol Biosynthesis 1.66 0.21 PNLIPRP2,CEL,DHRS9,PNLIPRP1,BCO1,PNPLA3,PNLIP Guanosine Nucleotides Degradation III 1.66 0.31 GDA,NT5E,XDH,AOX1 Glioma Invasiveness Signaling 1.60 0.18 RRAS,TIMP1,RHOC,HMMR,DIRAS3,MAPK3,PLAUR,PLAU,RHOF,ITGB5 Melatonin Degradation I 1.60 0.18 UGT1A6,CYP2E1,CYP2C18,CYP2C9,CYP2J2,CYP2B6,SULT1B1,UGT1A7 (includes others),CYP2S1,CYP2C19 Glucose and Glucose-1-phosphate Degradation 1.57 0.38 HK1,PGM3,RGN Heparan Sulfate Biosynthesis (Late Stages) 1.55 0.18 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 Cell Cycle Regulation by BTG Family Proteins 1.53 0.20 CCNE1,E2F1,BTG2,HOXB9,PPP2R2C,PPP2R1B,E2F2 Regulation of the Epithelial-Mesenchymal Transition Pathway 1.50 0.13 RRAS,FGFR1,TWIST1,EGF,FZD9,PARD6A,WNT8B,WNT2,MET,FGF17,FGFR3,FOXC2,CDH2,WNT7A,FGF10,WNT10A,WNT7B,MAPK3,FGF12,FGF20,LEF1,PDGFD,HMGA2,FGF19 HIF1α Signaling 1.50 0.15 EPO,NOS1,MMP7,MMP28,SLC2A1,MMP3,RRAS,MMP14,MMP10,LDHB,MAPK3,EGLN3,MMP11,MMP12,MMP1 Stearate Biosynthesis I (Animals) 1.47 0.19 FAM213B,CYP2E1,ACSL6,ACSL5,ELOVL2,ACOT7,ELOVL6 Signaling by Rho Family GTPases 1.44 0.12 SEPT9,ARPC1B,CDC42EP5,DIAPH3,DIRAS3,PIKFYVE,PARD6A,SLC9A1,NOX1,STMN1,ITGA3,GNA15,CDH3,EZR,MAPK3,CIT,BAIAP2,RHOF,NOX4,CFL1,RHOC,ACTB,ITGA2,KIAA1804,CDH2,PAK3,ARHGEF16,CDH17,PAK7 nNOS Signaling in Skeletal Muscle Cells 1.44 0.27 NOS1,RYR2,SNTB1,DMD Glutathione-mediated Detoxification 1.43 0.21 GSTA2,GSTM2,GSTA4,GSTA1,ANPEP,GSTP1 Rac Signaling 1.43 0.14 NOX4,ARPC1B,CFL1,RRAS,ITGA2,PIKFYVE,PARD6A,NOX1,ANK1,ITGA3,PAK3,MAPK3,BAIAP2,PAK7,IQGAP3 Leucine Degradation I 1.42 0.33 BCAT1,MCCC1,ACADM UDP-N-acetyl-D-galactosamine Biosynthesis II 1.42 0.33 HK1,PGM3,GALE Cyclins and Cell Cycle Regulation 1.42 0.15 CDKN2A,CCNA2,CDKN2D,CCNE1,E2F1,CCNB2,PPP2R2C,PPP2R1B,CDKN2B,CDK1,E2F2,CCNB1 Semaphorin Signaling in Neurons 1.41 0.17 MET,CFL1,PAK3,RHOC,DIRAS3,MAPK3,PAK7,RHOF,SEMA7A Colorectal Cancer Metastasis Signaling 1.40 0.12 MMP7,MMP3,PTGER3,MMP14,DIRAS3,EGF,WNT8B,WNT2,MYC,APPL1,WNT7A,WNT7B,MAPK3,MMP11,MMP12,RHOF,PTGER4,MMP1,MMP28,RHOC,RRAS,MMP10,FZD9,BAX,BIRC5,PRKAR2B,WNT10A,ADCY1,LEF1 α-tocopherol Degradation 1.39 0.50 CYP4F3,CYP4F12 Superpathway of Melatonin Degradation 1.38 0.16 UGT1A6,CYP2E1,CYP2C18,CYP2C9,CYP2J2,CYP2B6,SULT1B1,UGT1A7 (includes others),CYP2S1,CYP2C19 Chondroitin Sulfate Biosynthesis 1.36 0.17 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 Histamine Degradation 1.34 0.25 ALDH1A1,ALDH3B1,AOC1,ALDH3A1 Endothelin-1 Signaling 1.34 0.13 PLA2G16,NOS1,EDNRB,GUCY2C,RRAS,PLA2G10,PLA2G1B,SHC3,MYC,PLCD3,PLCE1,GNA15,ECE2,MAPK3,ADCY1,ITPR3,PLCB3,PLCB1,RARRES3,PNPLA3,PLA2G4F,PLA2G12A p53 Signaling 1.34 0.14 CDKN2A,TP53INP1,TP63,JMY,BAX,BIRC5,CCNG1,KAT2B,ADCK3,E2F1,SERPINB5,SFN,PML,TRIM29 Nicotine Degradation II 1.34 0.16 UGT1A6,CYP2E1,CYP2C18,CYP2C9,CYP2J2,AOX1,CYP2B6,UGT1A7 (includes others),CYP2S1,CYP2C19 PCP pathway 1.34 0.16 CELSR1,WNT7A,SDC1,WNT10A,WNT7B,EFNB1,FZD9,WNT8B,LGR4,WNT2 Integrin Signaling 1.33 0.12 RAC2,ARPC1B,DIRAS3,MYLK2,ITGA3,ITGA11,MAPK3,ITGB4,RHOF,ITGB5,VASP,CAPN5,RRAS,RHOC,ACTN2,ACTB,ITGA2,BCAR3,TTN,CAPN8,PAK3,TSPAN1,PAK7,CAPN9,ITGB6 Basal Cell Carcinoma Signaling 1.32 0.15 SHH,BMP4,WNT7A,WNT10A,GLIS1,WNT7B,FZD9,LEF1,BMP7,WNT8B,WNT2 Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.30 0.13 COL8A2,IL1A,FN1,EDNRB,COL4A3,FGFR1,MYH14,COL10A1,EGF,MYH7,BAX,COL17A1,MET,IL1R2,CYP2E1,TIMP1,IGFBP3,COL22A1,COL11A1,PDGFD,COL25A1,MMP1,COL7A1 Ephrin Receptor Signaling 1.29 0.13 RAC2,CFL1,ARPC1B,RRAS,GRIN2D,ITGA2,EFNA3,CXCL12,EGF,EPHA4,EFNA4,EFNB2,ITGA3,EPHA8,PAK3,GNA15,MAPK3,EFNB1,EFNA5,PAK7,PDGFD,EPHA2 Actin Nucleation by ARP-WASP Complex 1.28 0.16 ITGA3,ARPC1B,RRAS,RHOC,DIRAS3,ITGA2,BAIAP2,RHOF,VASP Neuropathic Pain Signaling In Dorsal Horn Neurons 1.27 0.14 KCNN4,CAMK1D,GRIN2D,GRIA1,KCNN2,GRM5,PLCD3,PLCE1,NTRK2,PRKAR2B,MAPK3,ITPR3,PLCB3,PLCB1 Regulation of Actin-based Motility by Rho 1.27 0.14 RAC2,ITGA3,PAK3,CFL1,ARPC1B,RHOC,ACTB,DIRAS3,BAIAP2,ITGA2,PIKFYVE,PAK7,RHOF Clathrin-mediated Endocytosis Signaling 1.26 0.12 STON2,LPA,ARPC1B,ACTB,CLTB,EGF,MET,APOL1,FGF17,ALB,LYZ,FGF10,ORM1,TF,FGF12,APOC1,FGF20,SERPINA1,ITGB4,PDGFD,ITGB6,ITGB5,FGF19 Ephrin A Signaling 1.26 0.17 EPHA8,CFL1,EFNA5,VAV3,EFNA3,EPHA4,EPHA2,EFNA4 Cholecystokinin/Gastrin-mediated Signaling 1.24 0.14 IL18,IL1A,IL1RN,RRAS,RHOC,MAPK3,DIRAS3,ITPR3,PLCB3,PLCB1,EPHA4,CCK,RHOF,CCKBR Heparan Sulfate Biosynthesis 1.23 0.16 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 Dermatan Sulfate Biosynthesis 1.23 0.16 SULT1E1,UST,SULT1C2,HS6ST2,HS3ST1,HS6ST3,HS3ST3A1,SULT1B1,SULT2B1 ERK/MAPK Signaling 1.22 0.12 PPARG,MYCN,RAC2,PPP1R14C,RRAS,PLA2G10,ITGA2,PLA2G1B,KSR1,MYC,ELF4,ITGA3,PRKAR2B,PAK3,PPP1R14D,MAPK3,MKNK1,RPS6KA4,PAK7,PPP2R2C,PLA2G4F,PPP2R1B,PLA2G12A Protein Citrullination 1.19 0.40 PADI4,PADI1 Serine Biosynthesis 1.19 0.40 PSAT1,PHGDH Citrulline-Nitric Oxide Cycle 1.19 0.40 NOS1,ASS1 Glutamate Degradation III (via 4-aminobutyrate) 1.19 0.40 ABAT,GAD1 Leukocyte Extravasation Signaling 1.19 0.12 RAC2,MMP7,MMP3,MMP28,ACTB,MMP14,ACTN2,CLDN18,ITGA2,CXCL12,MMP10,NOX1,SELPLG,ITGA3,CLDN23,CLDN4,TIMP1,VAV3,EZR,MMP11,CLDN2,MMP12,VASP,MMP1 FAK Signaling 1.12 0.14 CAPN5,CAPN8,ITGA3,PAK3,RRAS,HMMR,MAPK3,ACTB,ITGA2,EGF,PAK7,CAPN9 Role of MAPK Signaling in the Pathogenesis of Influenza 1.11 0.15 PLA2G16,RRAS,PLA2G10,MAPK3,PLA2G1B,RARRES3,PLA2G4F,PNPLA3,BAX,PLA2G12A Cysteine Biosynthesis III (mammalia) 1.10 0.21 CBS/CBSL,MAT1A,MAT2A,CTH Neuregulin Signaling 1.09 0.14 MYC,ITGA3,NRG2,NRG3,RRAS,ERBB4,MAPK3,ITGA2,NRG4,EGF,ERRFI1,EREG D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis 1.09 0.19 PLCD3,PLCE1,PIKFYVE,PLCB1,PLCB3 Virus Entry via Endocytic Pathways 1.06 0.14 RAC2,CD55,ITGA3,RRAS,HLA-A,ACTB,CLTB,ITGA2,HLA-B,ITGB4,ITGB6,ITGB5 Epithelial Adherens Junction Signaling 1.06 0.12 DLL1,TUBB3,LMO7,ARPC1B,RRAS,ACTB,ACTN2,FGFR1,MYH14,TUBA4A,EGF,MYH7,MET,CDH2,BAIAP2,LEF1,TUBA1C,JUP Thio-molybdenum Cofactor Biosynthesis 1.06 1.00 MOCOS L-cysteine Degradation II 1.06 1.00 CTH Asparagine Biosynthesis I 1.06 1.00 ASNS UDP-N-acetyl-D-galactosamine Biosynthesis I 1.06 1.00 GALE FXR/RXR Activation 1.05 0.13 APOL1,PPARG,IL18,ALB,IL1A,SDC1,ORM1,TF,NR1I2,IL1RN,FOXA1,APOC1,NR5A2,SERPINA1,VLDLR,FGF19 Antioxidant Action of Vitamin C 1.04 0.13 PLA2G16,PLCD3,PLCE1,SLC2A1,MAPK3,PLA2G10,PLA2G1B,PLCB3,PLCB1,RARRES3,PNPLA3,PLA2G4F,PLA2G12A Cardiomyocyte Differentiation via BMP Receptors 1.04 0.20 BMP4,MYH7,BMP7,GATA4 Purine Nucleotides Degradation II (Aerobic) 1.04 0.20 GDA,NT5E,XDH,AOX1 Synaptic Long Term Potentiation 1.02 0.13 PPP1R14C,RRAS,GRIN2D,GRIA1,GRM5,PLCD3,PLCE1,PRKAR2B,GNA15,PPP1R14D,MAPK3,ADCY1,ITPR3,PLCB3,PLCB1 Wnt/β-catenin Signaling 0.99 0.12 CDKN2A,MMP7,FZD9,SOX11,RARG,WNT8B,WNT2,MYC,APPL1,CDH2,WNT7A,WNT10A,CDH3,WNT7B,NR5A2,LEF1,PPP2R2C,KREMEN2,DKK1,PPP2R1B Role of CHK Proteins in Cell Cycle Checkpoint Control 0.98 0.15 CDC25C,E2F1,PPP2R2C,CLSPN,PLK1,PPP2R1B,CDK1,E2F2 Factors Promoting Cardiogenesis in Vertebrates 0.98 0.13 CCNE1,NOX4,BMP4,CDC6,TDGF1,FZD9,LEF1,MYH7,BMP7,DKK1,GATA4,NOG Ovarian Cancer Signaling 0.96 0.12 CDKN2A,MMP7,RRAS,EGF,FZD9,WNT8B,LHB,WNT2,RAD51,WNT7A,PRKAR2B,WNT10A,WNT7B,MAPK3,E2F1,LEF1 Leptin Signaling in Obesity 0.96 0.14 PLCD3,PLCE1,PRKAR2B,PDE3B,PDE3A,MAPK3,ADCY1,PLCB1,PLCB3,POMC RhoA Signaling 0.95 0.12 CFL1,SEPT9,NRP2,ARPC1B,ANLN,ACTB,CDC42EP5,MYLK2,PIKFYVE,TTN,LPAR3,EZR,BAIAP2,CIT,LPAR5 Sonic Hedgehog Signaling 0.93 0.17 SHH,PRKAR2B,GLIS1,CDK1,CCNB1 Superpathway of Citrulline Metabolism 0.93 0.21 NOS1,ASS1,GLS2 Urate Biosynthesis/Inosine 5'-phosphate Degradation 0.93 0.21 NT5E,XDH,AOX1 Superpathway of Serine and Glycine Biosynthesis I 0.92 0.29 PSAT1,PHGDH GDP-glucose Biosynthesis 0.92 0.29 HK1,PGM3 Ethanol Degradation IV 0.92 0.18 TYRP1,ALDH1A1,ALDH3B1,ALDH3A1 Graft-versus-Host Disease Signaling 0.91 0.15 HLA-G,IL1A,IL18,HLA-A,IL1RN,HLA-B,HLA-F BMP signaling pathway 0.90 0.13 SOSTDC1,BMP4,PRKAR2B,RRAS,MAPK3,BMP7,HOXC9,PITX2,NOG,CHRD Thyroid Cancer Signaling 0.88 0.15 PPARG,MYC,NTRK2,RRAS,MAPK3,LEF1 Neuroprotective Role of THOP1 in Alzheimer's Disease 0.88 0.15 HLA-G,PRKAR2B,ECE2,HLA-A,HLA-B,HLA-F ILK Signaling 0.86 0.11 FN1,CFL1,RHOC,ACTB,ACTN2,DIRAS3,MYH14,MUC1,MYH7,MYC,TGFB1I1,MAPK3,RPS6KA4,LEF1,PPP2R2C,ITGB4,ITGB6,RHOF,TMSB10/TMSB4X,PPP2R1B,ITGB5 TGF-β Signaling 0.86 0.13 INHA,BMP4,RRAS,FOXH1,MAPK3,BMP7,HOXC9,VDR,PITX2,AMHR2,PMEPA1 NAD biosynthesis II (from tryptophan) 0.86 0.20 HAAO,NMNAT3,KYNU Airway Pathology in Chronic Obstructive Pulmonary Disease 0.82 0.25 CELA2A,MMP1 Superoxide Radicals Degradation 0.82 0.25 TYRP1,NQO1 Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde 0.82 0.25 HAAO,KYNU Salvage Pathways of Pyrimidine Deoxyribonucleotides 0.82 0.25 CDA,TK1 Acute Phase Response Signaling 0.81 0.11 HAMP,IL1A,C4BPB,FN1,RRAS,C5,HP,IL18,ALB,ORM1,TF,F8,ITIH2,IL1RN,APCS,MAPK3,SERPINA1,SOCS7,CRABP2 MIF-mediated Glucocorticoid Regulation 0.80 0.15 PLA2G10,MAPK3,PLA2G1B,PLA2G4F,PLA2G12A Retinoate Biosynthesis I 0.80 0.15 ALDH1A1,AKR1C3,DHRS9,SDR16C5,AKR1B10 Extrinsic Prothrombin Activation Pathway 0.80 0.19 F12,F5,PROC Germ Cell-Sertoli Cell Junction Signaling 0.79 0.11 RAC2,TUBB3,CFL1,RHOC,RRAS,ACTB,ACTN2,DIRAS3,ITGA2,TUBA4A,CDH2,ITGA3,PAK3,MAPK3,TUBA1C,PAK7,JUP,RHOF Breast Cancer Regulation by Stathmin1 0.78 0.11 PPP1R14C,TUBB3,CAMK1D,RRAS,TUBA4A,CDK1,STMN1,CCNE1,PRKAR2B,PPP1R14D,ARHGEF16,MAPK3,E2F1,ADCY1,ITPR3,PLCB3,PLCB1,PPP2R2C,TUBA1C,PPP2R1B,E2F2 Epoxysqualene Biosynthesis 0.78 0.50 SQLE Alanine Degradation III 0.78 0.50 GPT2 Alanine Biosynthesis II 0.78 0.50 GPT2 4-hydroxyproline Degradation I 0.78 0.50 HOGA1 Threonine Degradation II 0.78 0.50 GCAT Glutamine Degradation I 0.78 0.50 GLS2 Glutamate Dependent Acid Resistance 0.78 0.50 GAD1 Oncostatin M Signaling 0.76 0.15 MMP3,RRAS,MAPK3,PLAU,MMP1 γ-linolenate Biosynthesis II (Animals) 0.74 0.18 ACSL6,ACSL5,CYB5A Adenosine Nucleotides Degradation II 0.74 0.18 NT5E,XDH,AOX1 Sucrose Degradation V (Mammalian) 0.74 0.22 ALDOA,ALDOC STAT3 Pathway 0.73 0.12 FGFR3,MYC,NTRK2,RRAS,FGFR1,MAPK3,INSR,SOCS7,KIAA1804 Cardiac β-adrenergic Signaling 0.73 0.11 PPP1R14C,PDE4C,PDE3A,RYR2,SLC8A2,AKAP3,AKAP7,PDE1C,PRKAR2B,PPP1R14D,PDE3B,ADCY1,PPP2R2C,PDE8B,PPP2R1B tRNA Splicing 0.73 0.14 PDE4C,PDE3B,PDE3A,PDE8B,PDE1C Ethanol Degradation II 0.73 0.14 ALDH1A1,DHRS9,ALDH3B1,ADHFE1,ALDH3A1 Human Embryonic Stem Cell Pluripotency 0.71 0.11 BMP4,FGFR1,TDGF1,FZD9,WNT8B,WNT2,NOG,FGFR3,WNT7A,NTRK2,WNT10A,WNT7B,LEF1,BMP7,PDGFD Pyridoxal 5'-phosphate Salvage Pathway 0.71 0.13 PAK3,SGK1,MAPK3,PAK7,PLK1,TTK,NEK2,CDK1 GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells 0.70 0.12 PLCD3,PLCE1,PRKAR2B,GNA15,ADCY1,ITPR3,LPAR5,PLCB1,PLCB3,CCK Valine Degradation I 0.69 0.17 BCAT1,ABAT,ALDH6A1 Oxidative Ethanol Degradation III 0.69 0.17 ALDH1A1,ALDH3B1,ALDH3A1 Cell Cycle Control of Chromosomal Replication 0.68 0.15 CDC45,CDT1,CDC6,ORC1 Dopamine Degradation 0.68 0.15 ALDH1A1,ALDH3B1,ALDH3A1,SULT1B1 Embryonic Stem Cell Differentiation into Cardiac Lineages 0.67 0.20 HOXB5,GATA4 Glycogen Degradation II 0.67 0.20 PGM3,PYGB Histidine Degradation VI 0.67 0.20 CYP2E1,AMDHD1 Glycine Betaine Degradation 0.67 0.20 SARDH,DMGDH ErbB Signaling 0.66 0.12 NRG2,PAK3,NRG3,RRAS,ERBB4,MAPK3,NRG4,EGF,PAK7,EREG Complement System 0.66 0.14 CD55,MASP2,C4BPB,C8G,C5 CCR3 Signaling in Eosinophils 0.65 0.11 PAK3,CFL1,RRAS,MAPK3,PLA2G10,ITPR3,PLA2G1B,PLCB3,PLCB1,PAK7,PLA2G4F,CCL26,PLA2G12A p38 MAPK Signaling 0.65 0.11 IL1A,TIFA,PLA2G10,PLA2G1B,IL1R2,MYC,IL18,IL1RN,MKNK1,PLA2G4F,RPS6KA4,IRAK2,PLA2G12A NRF2-mediated Oxidative Stress Response 0.64 0.11 AKR7A3,GSTA2,PRDX1,DNAJB4,RRAS,ACTB,GSTA4,NQO1,HERPUD1,DNAJB9,DNAJB13,GSTM2,MAPK3,GPX2,GSTA1,AOX1,EIF2AK3,GSTP1,EPHX1 GADD45 Signaling 0.64 0.16 CCNE1,CDK1,CCNB1 ErbB2-ErbB3 Signaling 0.64 0.12 MYC,NRG2,NRG3,RRAS,ETV4,MAPK3,NRG4 Glutamate Receptor Signaling 0.64 0.12 GRM5,SLC1A4,HOMER2,GRIN2D,GRIA1,SLC1A2,SLC1A1 Serotonin Degradation 0.64 0.12 ALDH1A1,DHRS9,UGT1A6,ALDH3B1,ADHFE1,ALDH3A1,SULT1B1,UGT1A7 (includes others) Noradrenaline and Adrenaline Degradation 0.63 0.13 ALDH1A1,DHRS9,ALDH3B1,ADHFE1,ALDH3A1 Trehalose Degradation II (Trehalase) 0.62 0.33 HK1 NADH Repair 0.62 0.33 GAPDH Methylglyoxal Degradation I 0.62 0.33 HAGHL Biotin-carboxyl Carrier Protein Assembly 0.62 0.33 ACACB Thyroid Hormone Biosynthesis 0.62 0.33 IYD 4-aminobutyrate Degradation I 0.62 0.33 ABAT G-Protein Coupled Receptor Signaling 0.62 0.10 VIPR2,PTGER3,PDE3A,HTR1D,AVPR1A,CHRM3,HRH1,HTR1B,GNA15,PDE3B,MAPK3,PLCB1,ADORA2B,PTGER4,RGS2,PDE4C,NPY1R,RRAS,PDE1C,GRM5,PRKAR2B,NPR3,GLP1R,ADCY1,PLCB3,PDE8B Macropinocytosis Signaling 0.62 0.12 MET,RRAS,EGF,ITGB4,RAB34,PDGFD,ITGB6,ITGB5 CDK5 Signaling 0.61 0.11 PPP1R14C,ITGA3,NTRK2,PRKAR2B,PPP1R14D,RRAS,MAPK3,ITGA2,ADCY1,PPP2R2C,PPP2R1B Molecular Mechanisms of Cancer 0.60 0.10 CDKN2A,RAC2,SHH,BMP4,DIRAS3,CDKN2B,WNT8B,WNT2,MYC,ITGA3,WNT7A,GNA15,MAPK3,WNT7B,PLCB1,RHOF,E2F2,CDC25C,RHOC,RRAS,ITGA2,FZD9,BAX,CDKN2D,CCNE1,PRKAR2B,WNT10A,PAK3,ARHGEF16,E2F1,ADCY1,PLCB3,IHH,LEF1,PAK7,BMP7 Putrescine Degradation III 0.60 0.15 ALDH1A1,ALDH3B1,ALDH3A1 Canonical Pathways -log(P-value) Ratio* Genes in pathway Netrin Signaling 0.60 0.13 RAC2,PRKAR2B,ABLIM3,RYR2,UNC5B Role of Tissue Factor in Cancer 0.59 0.11 PDIA2,P4HB,ITGA3,CFL1,GNA15,RRAS,MAPK3,PLAUR,PLCB1,RPS6KA4,ITGB5,MMP1 RhoGDI Signaling 0.59 0.10 ARPC1B,CFL1,RHOC,ARHGDIG,ACTB,DIRAS3,ITGA2,PIKFYVE,CDH2,ITGA3,GNA15,PAK3,CDH3,EZR,ARHGEF16,CDH17,PAK7,RHOF LXR/RXR Activation 0.59 0.11 IL1R2,APOL1,IL18,LYZ,ALB,IL1A,LPA,ORM1,TF,IL1RN,CD36,APOC1,SERPINA1 Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 0.58 0.11 LIFR,BMP4,WNT7A,WNT10A,RRAS,WNT7B,MAPK3,FZD9,BMP7,WNT8B,WNT2,GATA4 Melatonin Signaling 0.57 0.11 PLCD3,PLCE1,PRKAR2B,RORA,MAPK3,PLCB1,PLCB3,RORC Paxillin Signaling 0.57 0.11 ITGA3,PAK3,RRAS,ITGA11,ACTN2,ACTB,ITGA2,PAK7,ITGB4,ITGB6,ITGB5 Tryptophan Degradation III (Eukaryotic) 0.56 0.14 HAAO,ACAT1,KYNU Endoplasmic Reticulum Stress Pathway 0.56 0.14 ERN1,XBP1,EIF2AK3 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 0.55 0.10 TNFSF11,IL1A,BMP4,MMP3,MMP14,DLX5,ITGA2,FZD9,WNT8B,WNT2,IL1R2,IL18,ITGA3,WNT7A,WNT10A,IL1RN,WNT7B,MAPK3,LEF1,BMP7,DKK1,MMP1 cAMP-mediated signaling 0.55 0.10 RGS2,PDE4C,CAMK1D,VIPR2,PTGER3,NPY1R,PDE3A,HTR1D,AKAP3,CHRM3,AKAP7,PDE1C,HTR1B,PRKAR2B,NPR3,PDE3B,MAPK3,GLP1R,ADCY1,PDE8B,ADORA2B,PTGER4 Chemokine Signaling 0.55 0.11 CAMK1D,CFL1,RRAS,MAPK3,CXCL12,PLCB1,PLCB3,NOX1 Glycogen Degradation III 0.55 0.17 PGM3,PYGB Amyloid Processing 0.54 0.12 CAPN5,CAPN8,PRKAR2B,MAPK3,BACE1,CAPN9 MIF Regulation of Innate Immunity 0.54 0.12 PLA2G10,MAPK3,PLA2G1B,PLA2G4F,PLA2G12A Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 0.54 0.10 IL1A,FN1,MMP3,CXCL12,WNT8B,WNT2,IL1R2,MYC,PLCD3,PLCE1,WNT7A,WNT7B,MAPK3,PLCB1,PRSS3,MMP1,TNFSF11,RRAS,FZD9,PRSS1,C5,IL18,WNT10A,IL1RN,PLCB3,LEF1,DKK1,PDGFD,IRAK2 Salvage Pathways of Pyrimidine Ribonucleotides 0.53 0.11 PAK3,SGK1,MAPK3,AK4,PAK7,PLK1,TTK,NEK2,CDA,CDK1 Tryptophan Degradation X (Mammalian, via Tryptamine) 0.52 0.14 ALDH1A1,ALDH3B1,ALDH3A1 PPARα/RXRα Activation 0.52 0.10 PRKAB2,RRAS,CD36,CYP2C18,CYP2C9,CYP2C19,IL1R2,PLCD3,ACADL,PLCE1,PRKAR2B,GNA15,MAPK3,ADCY1,PLCB3,PLCB1,INSR,ITGB5 Fatty Acid β-oxidation I 0.51 0.13 ECI2,ACSL6,ACSL5,ACADM Superpathway of Methionine Degradation 0.51 0.13 CBS/CBSL,MAT1A,MAT2A,CTH Arsenate Detoxification I (Glutaredoxin) 0.51 0.25 AS3MT Catecholamine Biosynthesis 0.51 0.25 DBH Myo-inositol Biosynthesis 0.51 0.25 IMPA2 Fatty Acid β-oxidation III (Unsaturated, Odd Number) 0.51 0.25 ECI2 Ephrin B Signaling 0.51 0.11 RAC2,EFNB2,CFL1,GNA15,VAV3,EFNB1,MAPK3,CXCL12 PPAR Signaling 0.51 0.11 PPARG,IL1R2,IL1A,IL18,RRAS,IL1RN,MAPK3,INSR,PDGFD,CITED2 ERK5 Signaling 0.51 0.11 MYC,RRAS,SGK1,FOXO3,EGF,RPS6KA4,SFN Role of IL-17A in Psoriasis 0.50 0.15 CCL20,CXCL5 Fatty Acid Activation 0.50 0.15 ACSL6,ACSL5 Oleate Biosynthesis II (Animals) 0.50 0.15 CYB5A,ALDH6A1 Cholesterol Biosynthesis I 0.50 0.15 SQLE,EBP Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) 0.50 0.15 SQLE,EBP Cholesterol Biosynthesis III (via Desmosterol) 0.50 0.15 SQLE,EBP Glioma Signaling 0.50 0.11 CDKN2A,CDKN2D,CAMK1D,RRAS,MAPK3,E2F1,EGF,PDGFD,CDKN2B,E2F2 TR/RXR Activation 0.49 0.11 KLF9,ENO1,SLC16A3,HP,AKR1C3,SLC2A1,PDE3B,PFKP,SYT12 FGF Signaling 0.49 0.11 FGF17,FGFR3,MET,FGF10,FGFR1,MAPK3,FGF12,FGF20,FGF19 Cell Cycle: G1/S Checkpoint Regulation 0.49 0.11 CDKN2A,MYC,CDKN2D,CCNE1,E2F1,CDKN2B,E2F2 Dopamine-DARPP32 Feedback in cAMP Signaling 0.48 0.10 NOS1,KCNJ8,PPP1R14C,GRIN2D,KCNJ16,PLCD3,PLCE1,PRKAR2B,PPP1R14D,KCNJ5,ITPR3,ADCY1,PLCB3,PLCB1,PPP2R2C,PPP2R1B Non-Small Cell Lung Cancer Signaling 0.47 0.11 CDKN2A,RRAS,MAPK3,E2F1,FOXO3,ITPR3,EGF IGF-1 Signaling 0.47 0.10 PRKAR2B,RRAS,MAPK3,FOXO3,IGFBP3,IGFBP1,SOCS7,SFN,IGFBP2,GRB10 Isoleucine Degradation I 0.46 0.14 BCAT1,ACAT1 Androgen Biosynthesis 0.46 0.14 EBP,AKR1C3 Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism 0.45 0.13 INPP5J,IMPA2,ITPKA Sphingosine-1-phosphate Signaling 0.45 0.10 PLCD3,PLCE1,RHOC,DIRAS3,MAPK3,ADCY1,PLCB1,PLCB3,PDGFD,RHOF,SMPD3 phagosome formation 0.45 0.10 PLCD3,ITGA3,FN1,PLCE1,RHOC,DIRAS3,ITGA2,PLCB1,PLCB3,RHOF,MARCO UVA-Induced MAPK Signaling 0.44 0.10 PLCD3,PLCE1,RRAS,MAPK3,PLCB1,PLCB3,RPS6KA4,PARP3,SMPD3 Creatine-phosphate Biosynthesis 0.44 0.20 CKMT1A/CKMT1B Lysine Degradation II 0.44 0.20 AASS Galactose Degradation I (Leloir Pathway) 0.44 0.20 GALE Tyrosine Degradation I 0.44 0.20 HPD IL-17A Signaling in Fibroblasts 0.44 0.11 MAPK3,LCN2,CXCL5,MMP1 GABA Receptor Signaling 0.43 0.10 KCNN4,ABAT,GAD1,ADCY1,KCNN2,GABRD,GABRP MSP-RON Signaling Pathway 0.42 0.11 F11,F12,ACTB,MST1R,KLK1 Crosstalk between Dendritic Cells and Natural Killer Cells 0.42 0.10 HLA-G,IL2RG,IL18,HLA-A,FSCN1,ACTB,HLA-B,FSCN2,HLA-F Dendritic Cell Maturation 0.42 0.10 IL1A,HLA-A,HLA-B,COL10A1,CD58,PLCD3,IL18,PLCE1,CD1A,IL1RN,MAPK3,FSCN1,FSCN2,PLCB3,PLCB1,LY75,IL23A Gap Junction Signaling 0.42 0.10 TUBB3,GUCY2C,RRAS,ACTB,TUBA4A,EGF,PLCD3,PLCE1,PRKAR2B,MAPK3,ITPR3,ADCY1,PLCB3,PLCB1,TUBA1C γ-glutamyl Cycle 0.42 0.13 ANPEP,GGACT Remodeling of Epithelial Adherens Junctions 0.41 0.10 MET,TUBB3,ARPC1B,ACTN2,ACTB,TUBA4A,TUBA1C Sertoli Cell-Sertoli Cell Junction Signaling 0.41 0.10 NOS1,TUBB3,RRAS,ACTB,ACTN2,CLDN18,ITGA2,TUBA4A,TJP3,ITGA3,CLDN23,PRKAR2B,CLDN4,MAPK3,TUBA1C,CLDN2,JUP Calcium Signaling 0.41 0.10 TP63,CAMK1D,TNNI2,TNNC2,GRIN2D,GRIA1,MYH14,TNNT2,RYR2,MYH7,MCU,SLC8A2,PNCK,RCAN1,PRKAR2B,MAPK3,ITPR3 IL-12 Signaling and Production in Macrophages 0.41 0.10 APOL1,PPARG,IL18,LYZ,ALB,LPA,ORM1,MAPK3,APOC1,SERPINA1,IL12RB2,MST1R,IL23A Autoimmune Thyroid Disease Signaling 0.40 0.11 HLA-G,HLA-A,HLA-B,HLA-F,TG nNOS Signaling in Neurons 0.40 0.11 CAPN5,NOS1,CAPN8,GRIN2D,CAPN9 Antiproliferative Role of TOB in T Cell Signaling 0.40 0.12 CCNA2,CCNE1,PABPC4 CDP-diacylglycerol Biosynthesis I 0.38 0.13 LPCAT4,MBOAT2 Arginine Biosynthesis IV 0.37 0.17 ASS1 Proline Biosynthesis II (from Arginine) 0.37 0.17 PADI4 Pyruvate Fermentation to Lactate 0.37 0.17 LDHB Urea Cycle 0.37 0.17 ASS1 UDP-N-acetyl-D-glucosamine Biosynthesis II 0.37 0.17 PGM3 NAD Biosynthesis III 0.37 0.17 NMNAT3 Renal Cell Carcinoma Signaling 0.37 0.10 MET,SLC2A1,PAK3,RRAS,MAPK3,EGLN3,PAK7 ErbB4 Signaling 0.37 0.10 NRG2,NRG3,RRAS,ERBB4,MAPK3,NRG4 Mitochondrial L-carnitine Shuttle Pathway 0.35 0.12 ACSL6,ACSL5 Methionine Degradation I (to Homocysteine) 0.35 0.12 MAT1A,MAT2A 14-3-3-mediated Signaling 0.35 0.09 PLCD3,TUBB3,PLCE1,RRAS,MAPK3,TUBA4A,PLCB1,PLCB3,TUBA1C,BAX,SFN Superpathway of Cholesterol Biosynthesis 0.35 0.11 SQLE,EBP,ACAT1 Pancreatic Adenocarcinoma Signaling 0.35 0.09 RAD51,CDKN2A,CCNE1,CYP2E1,MAPK3,E2F1,EGF,CDKN2B,BIRC5,E2F2 Mouse Embryonic Stem Cell Pluripotency 0.34 0.09 LIFR,MYC,ID1,BMP4,RRAS,MAPK3,FZD9,LEF1,ID4 GNRH Signaling 0.34 0.09 PRKAR2B,PAK3,GNA15,RRAS,MAPK3,ADCY1,ITPR3,PLCB1,PLCB3,EGF,PAK7,LHB PTEN Signaling 0.34 0.09 FGFR3,RAC2,ITGA3,NTRK2,RRAS,FGFR1,MAPK3,ITGA2,FOXO3,INSR,CNKSR3 NAD Biosynthesis from 2-amino-3-carboxymuconate Semialdehyde 0.33 0.14 NMNAT3 Phosphatidylcholine Biosynthesis I 0.33 0.14 PCYT1B NAD Salvage Pathway III 0.33 0.14 NMNAT3 Pregnenolone Biosynthesis 0.33 0.14 CYP2E1 Phosphatidylglycerol Biosynthesis II (Non-plastidic) 0.32 0.11 LPCAT4,MBOAT2 D-myo-inositol (1,4,5)-trisphosphate Degradation 0.32 0.11 INPP5J,IMPA2 Endometrial Cancer Signaling 0.32 0.10 MYC,RRAS,MAPK3,FOXO3,LEF1 Gαs Signaling 0.31 0.09 RGS2,PRKAR2B,VIPR2,MAPK3,GLP1R,RYR2,ADCY1,ADORA2B,CHRM3,PTGER4 Amyotrophic Lateral Sclerosis Signaling 0.31 0.09 CAPN5,NOS1,CAPN8,GRIN2D,GRIA1,SLC1A2,CAPN9,BAX,SSR4 Cdc42 Signaling 0.30 0.09 ARPC1B,CFL1,HLA-A,CDC42EP5,DIAPH3,HLA-B,ITGA2,PARD6A,HLA-G,ITGA3,HLA-DQB2,PAK3,BAIAP2,HLA-F,IQGAP3 HER-2 Signaling in Breast Cancer 0.30 0.09 CCNE1,RRAS,EGF,ITGB4,ITGB6,PARD6A,ITGB5 VEGF Family Ligand-Receptor Interactions 0.30 0.09 NRP2,RRAS,PLA2G10,MAPK3,PLA2G1B,PLA2G4F,PLA2G12A AMPK Signaling 0.30 0.09 ULK1,ACACB,PRKAB2,SLC2A1,PFKFB1,ACTB,CFTR,PFKP,CCNA2,PRKAR2B,KAT2B,FOXO3,AK4,PPP2R2C,INSR,PPP2R1B Telomerase Signaling 0.30 0.09 MYC,ELF4,IL2RG,RRAS,MAPK3,E2F1,EGF,PPP2R2C,PPP2R1B 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian) 0.30 0.11 INPP5J,ITPKA D-myo-inositol (1,3,4)-trisphosphate Biosynthesis 0.30 0.11 INPP5J,ITPKA Melanoma Signaling 0.29 0.10 CDKN2A,RRAS,MAPK3,E2F1 Thrombin Signaling 0.29 0.09 CAMK1D,RHOC,RRAS,DIRAS3,EGF,PLCD3,PLCE1,GNA15,ARHGEF16,MAPK3,ITPR3,ADCY1,PLCB3,PLCB1,GATA3,RHOF,GATA4 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 0.29 0.09 PPP1R14C,LPA,RHOC,DIRAS3,APOL1,ALB,LYZ,ORM1,PPP1R14D,MAPK3,HOXA10,APOC1,SERPINA1,PPP2R2C,RHOF,PPP2R1B Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza 0.29 0.09 WNT7A,WNT10A,WNT7B,FZD9,LEF1,WNT8B,WNT2 Sphingosine and Sphingosine-1-phosphate Metabolism 0.28 0.13 SGPP2 Histidine Degradation III 0.28 0.13 AMDHD1 Citrulline Biosynthesis 0.28 0.13 GLS2 Sphingomyelin Metabolism 0.28 0.13 SMPD3 Communication between Innate and Adaptive Immune Cells 0.28 0.09 HLA-G,IL1A,IL18,HLA-A,IL1RN,HLA-B,HLA-F,CCL15 PAK Signaling 0.28 0.09 ITGA3,CFL1,PAK3,RRAS,MAPK3,ITGA2,PAK7,PDGFD Apoptosis Signaling 0.28 0.09 GAS2,CAPN5,CAPN8,RRAS,MAPK3,CAPN9,BAX,CDK1 Angiopoietin Signaling 0.28 0.09 ANGPTL1,GRB14,PAK3,RRAS,PAK7,BIRC5 Gαq Signaling 0.28 0.09 GRM5,HRH1,RGS2,GNA15,RHOC,MAPK3,DIRAS3,ITPR3,PLCB3,PLCB1,RHOF,CHRM3,AVPR1A VDR/RXR Activation 0.28 0.09 TNFSF11,HOXA10,IGFBP3,IGFBP1,VDR,CST6,HR Reelin Signaling in Neurons 0.26 0.09 ITGA3,ARHGEF16,ITGA2,LRP8,VLDLR,MAPK8IP1,PAFAH1B3 Acute Myeloid Leukemia Signaling 0.26 0.09 MYC,RRAS,MAPK3,FLT3,LEF1,JUP,PML Wnt/Ca+ pathway 0.26 0.09 PLCD3,PLCE1,PLCB1,PLCB3,FZD9 GDNF Family Ligand-Receptor Interactions 0.26 0.09 PDLIM7,NRTN,DOK4,RRAS,MAPK3,ITPR3 Circadian Rhythm Signaling 0.25 0.09 ADCYAP1R1,VIPR2,GRIN2D G Protein Signaling Mediated by Tubby 0.25 0.09 PLCB1,PLCB3,INSR Prostanoid Biosynthesis 0.25 0.11 PTGES Ketolysis 0.25 0.11 ACAT1 Maturity Onset Diabetes of Young (MODY) Signaling 0.23 0.09 GAPDH,INSR Polyamine Regulation in Colon Cancer 0.23 0.09 PPARG,MYC Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I 0.23 0.09 RRM2,AK4 Ketogenesis 0.22 0.10 ACAT1 Calcium Transport I 0.22 0.10 ATP2C2 Mineralocorticoid Biosynthesis 0.20 0.09 EBP *The percentage of genes in a pathway that were differentially expressed. P values presented are genearted using a right tailed Fisher's exact test.