Apheresis units UMDNS GMDN 16405, 23134, Apheresis units 16405 Apheresis unit 23135, 23136, 23137, 23139 Other common names: Blood cell processors, blood component separators, plasma blood donor apheresis units, platelet blood donor apheresis units, therapeutic apheresis units
Health problem addressed Apheresis systems collect and separate blood components for donation; they can also remove or exchange substances in therapeutic procedures. Therapeutic apheresis is used on patients with Goodpasture syndrome, preeclampsia and eclampsia in pregnancy, leukostasis cause by elevated white blood count in leukemia, systemic lupus, vasculitis, polymyositis or dermatomyositis, severe rheumatoid arthritis, or to reduce risk of antibody-mediated rejection of organ transplants. Product description Apheresis units incorporate polyvinyl tubing that draws blood from the patient and moves it through centrifuges and/or filters to separate blood products. The blood is then returned to the patient via tubing or is collected in bags, often suspended from perforation, have been reported. Hemolysis a pole, for donation or disposal. A display and control panel is associated with kinked tubing or poorly allow the operator to program the unit and view progress and/ connected sets. Decreased ionized calcium in or alerts. Safety features include pressure sensors, ultrasonic the plasma could lead to cardiac arrhythmia. air-bubble detectors, optical fluid-level detectors, and dry-heat Blood or blood component transfusions pose fluid warmers. The warmers help prevent hypothermia caused a risk of infection such as hepatitis and AIDS. by infusing low-temperature fluids. The unit may have wheels or it may be placed on a cart. Hospital medical equipment - general information Use and maintenance Principles of operation User(s): Nurse or technician Maintenance: Biomedical engineering staff The operator programs the unit to run the desired separation and/or service contract with the manufacturer protocol; the unit automatically controls the centrifuge, pump, or third-party organization and other settings. Rotary peristaltic pumps draw blood from the Training: Manufacturer-provided training, 2012 patient or donor and pump blood through filters or centrifuges. Filters separate blood components based on size; centrifuges manual separate by density. Optical sensors detect plasma-cell Environment of use interfaces to minimize contamination from other components. Settings of use: Hospital; clinic; outpatient Centrifuges have inlet and outlet ports and compartments to clinic keep components separated. Pumps move the blood products Requirements: Line power, biohazard disposal into collection bags, add anticoagulant, and reinfuse fluids. Replacement fluids (e.g., saline, serum albumin, plasma protein Product specifications fraction, fresh frozen plasma) are infused into the patient to Approx. dimensions (mm): 920 x 550 x 700 maintain appropriate intravascular volume and pressure. Approx. weight (kg): 95 Operating steps Consumables: Sets, tubing, anticoagulant & replacement fluids • Apheresis machines are wheeled to the bedside or donor 20,000-157,000; (50,000 chair. Price range (USD): typical); price covers all types and variations • Operator connects the sterile tubing sets, also called pheresis sets, to the patient or donor. Typical product life time: 8 years • As the patient’s blood is pumped into the machine, an Shelf life (consumables): 1-2 months for anticoagulant is automatically added and the blood enters anticoagulant; 2-5 days for platelets the chamber. • Blood components are separated using centrifugation and/ Types and variations • Units designed only for donor collection, or filtration; the method of separation depends on the therapeutic exchange, therapeutic removal, product that is to be removed or collected from the blood. or a combination of these Reported problems • Continuous units that enable simultaneous Air embolism is a risk despite the presence of air-bubble detectors blood removal and return (requires two in most apheresis units. Complications related to double-lumen access sites; contraindicated in some patients) venous catheter placement, such as vascular erosion and
© Copyright ECRI Institute 2012 (not including GMDN codes and device names). UMDNS codes and devices names: © Copyright ECRI Institute 2012. Reproduced with Permission from ECRI Institute’s Healthcare Product Comparison System. http://www.who.int/medical_devices GMDN Codes and Term Names: © Copyright and database rights: GMDN Agency Ltd 2005-2012. All rights reserved.