June 6, 2017 u vol. 114 u no. 23

From the Cover

5782 regulatory networks E4549 Focal adhesions on fibrous matrices 6056 Tropical forest disturbance and biodiversity loss 6110 Bacterial endosymbiont in coconut beetle

Contents

THIS WEEK IN PNAS 5761 In This Issue Cover image: Pictured is a light microscope image of a larval eye LETTERS (ONLINE ONLY) disc from a fruit fly (Drosophila melanogaster), showing expression of E4524 Inhibitors of hepatitis C virus entry may be potent ingredients of optimal eyg (orange) and loss of ey and toy drug combinations (blue) , which regulate eye Pranesh Padmanabhan and Narendra M. Dixit development. The articles in the Sackler E4527 Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally Colloquium on Gene Regulatory boosting direct-acting antiviral-based treatments Networks and Network Models in Hirofumi Ohashi, Yoshiki Koizumi, Kento Fukano, Takaji Wakita, Alan S. Perelson, Shingo Development and Evolution explore the Iwami, and Koichi Watashi impact of gene networks on topics such as cell differentiation, immunology, INNER WORKINGS—An over-the-shoulder look at scientists at work paleontology, and behavior. See the Introduction to the Sackler Colloquium 5763 Listening in on the deep sea by Neil Shubin on pages 5782–5783. Beans Image courtesy of Jinjin Zhu and Justin P. Kumar. CORE CONCEPTS—A brief introduction to emerging topics in science 5766 How Bose–Einstein condensates keep revealing weird physics Stephen Ornes

QNAS 5769 QnAs with Alta Charo and George Church Prashant Nair

COMMENTARIES 5772 The fibrous cellular microenvironment, and how cells make sense of a tangled web Delaram Shakiba, Behzad Babaei, Fatemeh Saadat, Stavros Thomopoulos, and Guy M. Genin See companion article on page E4549 5775 Global biodiversity loss from tropical deforestation Xingli Giam See companion article on page 6056

PNAS PLUS 5778 Significance Statements Brief statements written by the authors about the significance of their papers.

Free online through the PNAS open access option. PNAS u June 6, 2017 u vol. 114 u no. 23 u iii–viii Downloaded by guest on September 25, 2021 5878 Whole-organism cellular gene-expression atlas reveals ARTHUR M. SACKLER COLLOQUIUM ON GENE conserved cell types in the ventral nerve cord of REGULATORY NETWORKS AND NETWORK MODELS IN Platynereis dumerilii DEVELOPMENT AND EVOLUTION Hernando Martı´nez Vergara, Paola Yanina Bertucci, Peter Hantz, Maria Antonietta Tosches, Kaia Achim, Pavel INTRODUCTION Vopalensky, and Detlev Arendt 5782 Gene regulatory networks and network models in 5886 Applying gene regulatory network logic to the development and evolution evolution of social behavior Neil Shubin Nicole M. Baran, Patrick T. McGrath, and J. Todd Streelman

COLLOQUIUM PAPERS PHYSICAL SCIENCES 5784 Causes and evolutionary consequences of primordial germ-cell specification mode in metazoans APPLIED MATHEMATICS Carrie A. Whittle and Cassandra G. Extavour 6046 Spatial evolutionary games with weak selection 5792 Logical modeling of lymphoid and myeloid cell Mridu Nanda and Richard Durrett specification and transdifferentiation Samuel Collombet, Chris van Oevelen, Jose Luis APPLIED PHYSICAL SCIENCES Sardina Ortega, Wassim Abou-Jaoude´, Bruno Di 5894 Syringe-injectable mesh electronics integrate seamlessly Stefano, Morgane Thomas-Chollier, Thomas Graf, with minimal chronic immune response in the brain and Denis Thieffry Tao Zhou, Guosong Hong, Tian-Ming Fu, Xiao Yang, Thomas G. 5800 Bcl11b and combinatorial resolution of cell fate in the Schuhmann, Robert D. Viveros, and M. Lieber T-cell gene regulatory network 5900 Bio-inspired self-healing structural color hydrogel William J. R. Longabaugh, Weihua Zeng, Jingli A. Zhang, Fanfan Fu, Zhuoyue Chen, Ze Zhao, Huan Wang, Luoran Shang, Hiroyuki Hosokawa, Camden S. Jansen, Long Li, Maile Zhongze Gu, and Yuanjin Zhao Romero-Wolf, Pentao Liu, Hao Yuan Kueh, Ali Mortazavi, and Ellen V. Rothenberg BIOPHYSICS AND COMPUTATIONAL BIOLOGY 5808 Gene regulation during Drosophila 5906 Mechanosensing of shear by Pseudomonas aeruginosa eggshell patterning leads to increased levels of the cyclic-di-GMP George Pyrowolakis, Ville Veikkolainen, Nir Yakoby, and Stanislav Y. Shvartsman signal initiating biofilm development Christopher A. Rodesney, Brian Roman, Numa Dhamani, 5814 Dissecting BMP signaling input into the gene Benjamin J. Cooley, Ahmed Touhami, and Vernita D. Gordon regulatory networks driving specification of the blood stem cell lineage CHEMISTRY Arif Kirmizitas, Stuart Meiklejohn, Aldo Ciau-Uitz, Rachel Stephenson, and Roger Patient 5912 B12-dependent photoresponsive protein hydrogels for controlled stem cell/protein release 5822 Reconstructing blood stem cell regulatory network Ri Wang, Zhongguang Yang, Jiren Luo, I-Ming Hsing, models from single-cell molecular profiles and Fei Sun Fiona K. Hamey, Sonia Nestorowa, Sarah J. Kinston, David G. 5918 Engineering Cu surfaces for the electrocatalytic Kent, Nicola K. Wilson, and Berthold Go¨ttgens conversion of CO2: Controlling selectivity 5830 Gene regulatory networks and cell lineages that toward oxygenates and hydrocarbons underlie the formation of Christopher Hahn, Toru Hatsukade, Youn-Geun Kim, Arturas Margaret Buckingham Vailionis, Jack H. Baricuatro, Drew C. Higgins, Stephanie A. 5838 Dynamic regulation of Nanog and stem cell-signaling Nitopi, Manuel P. Soriaga, and Thomas F. Jaramillo pathways by Hoxa1 during early neuro-ectodermal 5924 Understanding the essential proton-pumping kinetic differentiation of ES cells gates and decoupling mutations in cytochrome Bony De Kumar, Hugo J. Parker, Mark E. Parrish, Jeffrey J. c oxidase Lange, Brian D. Slaughter, Jay R. Unruh, Ariel Paulson, Ruibin Liang, Jessica M. J. Swanson, Ma˚rten Wikstro¨m, and Robb Krumlauf and Gregory A. Voth 5846 Drosophila Pax6 promotes development of the entire 5930 Confined catalysis under two-dimensional materials eye-antennal disc, thereby ensuring proper adult Haobo Li, Jianping Xiao, Qiang Fu, and Xinhe Bao head formation Jinjin Zhu, Sneha Palliyil, Chen Ran, and Justin P. Kumar 5935 Melting dynamics of ice in the mesoscopic regime 5854 Genome-wide use of high- and low-affinity Tbrain Margherita Citroni, Samuele Fanetti, Naomi Falsini, Paolo transcription factor binding sites during Foggi, and Roberto Bini echinoderm development EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Gregory A. , Alys M. Cheatle Jarvela, Rene D. Francolini, − and Veronica F. Hinman 5941 Pyrite sulfur isotopes reveal glacial interglacial environmental changes 5862 Assessing regulatory information in developmental Virgil Pasquier, Pierre Sansjofre, Marina Rabineau, Sidonie gene regulatory networks Revillon, Jennifer Houghton, and David A. Fike Isabelle S. Peter and Eric H. Davidson 5870 Paleogenomics of echinoids reveals an ancient origin ENVIRONMENTAL SCIENCES for the double-negative specification of micromeres 5946 Reassessment of 20th century global mean sea in sea urchins level rise Jeffrey R. Thompson, Eric M. Erkenbrack, Veronica F. Hinman, So¨nke Dangendorf, Marta Marcos, Guy Wo¨ppelmann, Brenna S. McCauley, Elizabeth Petsios, and David J. Bottjer Clinton P. Conrad, Thomas Frederikse, and Riccardo Riva

iv u www.pnas.org Contents Downloaded by guest on September 25, 2021 5952 High Arctic Holocene temperature record from the ANTHROPOLOGY Agassiz ice cap and Greenland ice sheet evolution 6000 Thoracic vertebral count and thoracolumbar transition Benoit S. Lecavalier, David A. Fisher, Glenn A. Milne, Bo M. in Australopithecus afarensis Vinther, Lev Tarasov, Philippe Huybrechts, Denis Lacelle, Carol V. Ward, Thierra K. Nalley, Fred Spoor, Paul Tafforeau, Brittany Main, James Zheng, Jocelyne Bourgeois, and Zeresenay Alemseged and Arthur S. Dyke

APPLIED BIOLOGICAL SCIENCES PHYSICS 6005 Blue fluorescent amino acid for biological 5958 Active depinning of bacterial droplets: The collective spectroscopy and microscopy surfing of Bacillus subtilis Mary Rose Hilaire, Ismail A. Ahmed, Chun-Wei Lin, Hyunil Jo, Marc Hennes, Julien Tailleur, Gae¨lle Charron, and Adrian Daerr William F. DeGrado, and Feng Gai

SOCIAL SCIENCES E4539 Mechanistic insight into the nucleus–vacuole junction ANTHROPOLOGY based on the Vac8p–Nvj1p crystal structure 6068 Collective action and the evolution of social Hanbin Jeong, Jumi Park, Hye-In Kim, Miriam Lee, Young-Joon norm internalization Ko, Sanghwa Lee, Youngsoo Jun, and Changwook Lee Sergey Gavrilets and Peter J. Richerson 5912 B12-dependent photoresponsive protein hydrogels for controlled stem cell/protein release PSYCHOLOGICAL AND COGNITIVE SCIENCES Ri Wang, Zhongguang Yang, Jiren Luo, I-Ming Hsing, E4530 Spatiotemporal dynamics of word retrieval in speech and Fei Sun production revealed by cortical high-frequency 6010 Interplay of catalysis, fidelity, threading, and band activity processivity in the exo- and endonucleolytic Stephanie K. Rie`s, Rummit K. Dhillon, Alex Clarke, David reactions of human exonuclease I King-Stephens, Kenneth D. Laxer, Peter B. Weber, Rachel A. Yuqian Shi, Homme W. Hellinga, and Lorena S. Beese Kuperman, Kurtis I. Auguste, Peter Brunner, Gerwin Schalk, Jack J. Lin, Josef Parvizi, Nathan E. Crone, Nina F. Dronkers, 6016 Histone-binding of DPF2 mediates its repressive role and Robert T. Knight in myeloid differentiation 5964 Female peer mentors early in college increase women’s Ferdinand M. Huber, Sarah M. Greenblatt, Andrew M. positive academic experiences and retention Davenport, Concepcion Martinez, Ye Xu, Ly P. Vu, in engineering Stephen D. Nimer, and Andre´ Hoelz Tara C. Dennehy and Nilanjana Dasgupta 6022 Mechanism of H2S-mediated protection against oxidative stress in Escherichia coli 5970 Facial appearance affects science communication Ana I. Gheorghiu, Mitchell J. Callan, and William J. Skylark Alexander Mironov, Tatyana Seregina, Maxim Nagornykh, Lyly G. Luhachack, Natalya Korolkova, Liubov Errais Lopes, 5976 Perceived social presence reduces fact-checking Vera Kotova, Gennady Zavilgelsky, Rustem Shakulov, Konstantin Shatalin, and Evgeny Nudler Youjung Jun, Rachel Meng, and Gita Venkataramani Johar 6028 Evolutionary steps involving counterion displacement 5982 Mental models accurately predict emotion transitions in a tunicate opsin Mark A. Thornton and Diana I. Tamir Keiichi Kojima, Takahiro Yamashita, Yasushi Imamoto, Takehiro G. Kusakabe, Motoyuki Tsuda, and Yoshinori Shichida SUSTAINABILITY SCIENCE 5946 Reassessment of 20th century global mean sea BIOPHYSICS AND COMPUTATIONAL BIOLOGY level rise E4549 Multiscale model predicts increasing focal adhesion So¨nke Dangendorf, Marta Marcos, Guy Wo¨ppelmann, size with decreasing stiffness in fibrous matrices Clinton P. Conrad, Thomas Frederikse, and Riccardo Riva Xuan Cao, Ehsan Ban, Brendon M. Baker, Yuan Lin, Jason A. 6052 Exceptional and rapid accumulation of anthropogenic Burdick, Christopher S. Chen, and Vivek B. Shenoy debris on one of the world’s most remote and See Commentary on page 5772 pristine islands E4556 Physicochemical code for quinary protein interactions Jennifer L. Lavers and Alexander L. Bond in Escherichia coli Xin Mu, Seongil Choi, Lisa Lang, David Mowray, Nikolay V. Dokholyan, Jens Danielsson, and Mikael Oliveberg BIOLOGICAL SCIENCES E4564 Angular measurements of the dynein ring reveal AGRICULTURAL SCIENCES a stepping mechanism dependent on a flexible stalk 5988 Healthy offspring from freeze-dried mouse Lisa G. Lippert, Tali Dadosh, Jodi A. Hadden, Vishakha spermatozoa held on the International Space Karnawat, Benjamin T. Diroll, Christopher B. Murray, Erika L. F. Holzbaur, Klaus Schulten, Samara L. Station for 9 months Reck-Peterson, and Yale E. Goldman Sayaka Wakayama, Yuko Kamada, Kaori Yamanaka, Takashi Kohda, Hiromi Suzuki, Toru Shimazu, Motoki N. Tada, Ikuko Osada, Aiko 5822 Reconstructing blood stem cell regulatory network Nagamatsu, Satoshi Kamimura, Hiroaki Nagatomo, Eiji Mizutani, models from single-cell molecular profiles Fumitoshi Ishino, Sachiko Yano, and Teruhiko Wakayama Fiona K. Hamey, Sonia Nestorowa, Sarah J. Kinston, David G. 5994 Insect pathogenic fungus interacts with the gut Kent, Nicola K. Wilson, and Berthold Go¨ttgens microbiota to accelerate mosquito mortality 5958 Active depinning of bacterial droplets: The collective Ge Wei, Yiling Lai, Guandong Wang, Huan Chen, Fang Li, surfing of Bacillus subtilis and Sibao Wang Marc Hennes, Julien Tailleur, Gae¨lle Charron, and Adrian Daerr

Contents PNAS u June 6, 2017 u vol. 114 u no. 23 u v Downloaded by guest on September 25, 2021 6034 Changes in conformational equilibria regulate the 5878 Whole-organism cellular gene-expression atlas reveals activity of the Dcp2 decapping enzyme conserved cell types in the ventral nerve cord of Jan Philip Wurm, Iris Holdermann, Jan H. Overbeck, Platynereis dumerilii Philipp H. O. Mayer, and Remco Sprangers Hernando Martı´nez Vergara, Paola Yanina Bertucci, Peter 6040 Nanomechanics of the substrate binding domain of Hantz, Maria Antonietta Tosches, Kaia Achim, Pavel Hsp70 determine its allosteric ATP-induced Vopalensky, and Detlev Arendt conformational change Soumit Sankar Mandal, Dale R. Merz, Maximilian Buchsteiner, ECOLOGY Ruxandra I. Dima, Matthias Rief, and Gabriel Zˇolda´k 6046 Spatial evolutionary games with weak selection Mridu Nanda and Richard Durrett CELL BIOLOGY 6052 Exceptional and rapid accumulation of anthropogenic E4574 Selective regulation of Notch ligands during debris on one of the world’s most remote and angiogenesis is mediated by vimentin pristine islands Daniel Antfolk, Marika Sjo¨qvist, Fang Cheng, Kimmo Jennifer L. Lavers and Alexander L. Bond Isoniemi, Camille L. Duran, Adolfo Rivero-Muller, Christian 6056 Effects of habitat disturbance on tropical Antila, Rasmus Niemi, Sebastian Landor, Carlijn V. C. Bouten, Kayla J. Bayless, John E. Eriksson, forest biodiversity and Cecilia M. Sahlgren John Alroy See Commentary on page 5775 E4582 Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries ENVIRONMENTAL SCIENCES Xiju He, Shoutian Li, Benju Liu, Sebastian Susperreguy, Karina 6062 Discovery of a widespread metabolic pathway within Formoso, Jinghong Yao, Jinsong Kang, Anbing Shi, Lutz and among phenolic xenobiotics Birnbaumer, and Yanhong Liao Pahriya Ashrap, Guomao Zheng, Yi Wan, Tong Li, Wenxin Hu, Wenjuan Li, Hong Zhang, Zhaobin Zhang, and Jianying Hu E4592 Data-driven modeling reveals cell behaviors EVOLUTION controlling self-organization during Myxococcus E4602 Integrative modeling of gene and genome evolution xanthus development roots the archaeal tree of life Christopher R. Cotter, Heinz-Bernd Schu¨ttler, Oleg A. Igoshin, Tom A. Williams, Gergely J. Szo¨llosi,} Anja Spang, Peter G. and Lawrence J. Shimkets Foster, Sarah E. Heaps, Bastien Boussau, Thijs J. G. Ettema, 5800 Bcl11b and combinatorial resolution of cell fate in the and T. Martin Embley T-cell gene regulatory network 5784 Causes and evolutionary consequences of primordial William J. R. Longabaugh, Weihua Zeng, Jingli A. Zhang, germ-cell specification mode in metazoans Hiroyuki Hosokawa, Camden S. Jansen, Long Li, Maile Carrie A. Whittle and Cassandra G. Extavour Romero-Wolf, Pentao Liu, Hao Yuan Kueh, Ali Mortazavi, and Ellen V. Rothenberg 5870 Paleogenomics of echinoids reveals an ancient origin 5808 Gene regulation during Drosophila for the double-negative specification of micromeres eggshell patterning in sea urchins Jeffrey R. Thompson, Eric M. Erkenbrack, Veronica F. Hinman, George Pyrowolakis, Ville Veikkolainen, Nir Yakoby, Brenna S. McCauley, Elizabeth Petsios, and David J. Bottjer and Stanislav Y. Shvartsman 5814 Dissecting BMP signaling input into the gene 6068 Collective action and the evolution of social regulatory networks driving specification of norm internalization the blood stem cell lineage Sergey Gavrilets and Peter J. Richerson Arif Kirmizitas, Stuart Meiklejohn, Aldo Ciau-Uitz, Rachel 6074 Extraordinarily rapid speciation in a marine fish Stephenson, and Roger Patient Paolo Momigliano, Henri Jokinen, Antoine Fraimout, Ann-Britt 5830 Gene regulatory networks and cell lineages that Florin, Alf Norkko, and Juha Merila¨ underlie the formation of skeletal muscle Margaret Buckingham GENETICS 5838 Dynamic regulation of Nanog and stem cell-signaling 6080 Repression of phosphatidylinositol transfer protein pathways by Hoxa1 during early neuro-ectodermal α ameliorates the pathology of Duchenne differentiation of ES cells muscular dystrophy Bony De Kumar, Hugo J. Parker, Mark E. Parrish, Jeffrey J. Natassia M. Vieira, Janelle M. Spinazzola, Matthew S. Alexander, Lange, Brian D. Slaughter, Jay R. Unruh, Ariel Paulson, Yuri B. Moreira, Genri Kawahara, Devin E. Gibbs, Lillian C. Mead, and Robb Krumlauf Sergio Verjovski-Almeida, Mayana Zatz, and Louis M. Kunkel 5846 Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult IMMUNOLOGY AND INFLAMMATION head formation E4612 cGAS is essential for cellular senescence Jinjin Zhu, Sneha Palliyil, Chen Ran, and Justin P. Kumar Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, 5854 Genome-wide use of high- and low-affinity Tbrain and Zhijian J. Chen + + transcription factor binding sites during 6086 CCR8 FOXp3 Treg cells as master drivers of echinoderm development immune regulation Gregory A. Cary, Alys M. Cheatle Jarvela, Rene D. Francolini, Yiftah Barsheshet, Gizi Wildbaum, Eran Levy, Alon Vitenshtein, and Veronica F. Hinman Chika Akinseye, Jeremy Griggs, Sergio A. Lira, and Nathan Karin

vi u www.pnas.org Contents Downloaded by guest on September 25, 2021 6092 Inducible CTCF insulator delays the IgH 3′ regulatory E4658 Modulation of sensory information processing by region-mediated activation of germline promoters a neuroglobin in Caenorhabditis elegans and alters class switching Shigekazu Oda, Yu Toyoshima, and Mario de Bono Fatima-Zohra Braikia, Chloe´ Oudinet, Dania Haddad, Zeliha E4666 Parallel memory traces are built after an experience Oruc, Domenico Orlando, Audrey Dauba, Marc Le Bert, containing aversive and appetitive components in and Ahmed Amine Khamlichi the crab Neohelice MEDICAL SCIENCES Martı´n Klappenbach, Ayele´n Nally, and Fernando Federico Locatelli E4621 The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to E4676 KEAP1-modifying small molecule reveals muted NRF2 maintain the kidney filtration barrier signaling responses in neural stem cells from ’ Christoph Schell, Manuel Rogg, Martina Suhm, Martin Huntington s disease patients Helmsta¨dter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Luisa Quinti, Sharadha Dayalan Naidu, Ulrike Tra¨ger, Xiqun Kretz, Victoria Ku¨ttner, Hani Suleiman, Laxmikanth Kollipara, Chen, Kimberly Kegel-Gleason, David Lle`res, Colu´m Rene´ P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Connolly, Vanita Chopra, Cho Low, Se´bastien Moniot, Ellen Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Sapp, Adelaide R. Tousley, Petr Vodicka, Michael J. Van Takaya Abe, Shinichi Aizawa, Florian Grahammer, Bjo¨rn Kanegan, Linda S. Kaltenbach, Lisa A. Crawford, Matthew Hartleben, Jo¨rn Dengjel, and Tobias B. Huber Fuszard, Maureen Higgins, James R. C. Miller, Ruth E. Farmer, Vijay Potluri, Susanta Samajdar, Lisa Meisel, Ningzhe E4631 RNA editing of SLC22A3 drives early tumor invasion Zhang, Andrew Snyder, Ross Stein, Steven M. Hersch, Lisa M. and metastasis in familial esophageal cancer Ellerby, Eranthie Weerapana, Michael A. Schwarzschild, Li Fu, Yan-Ru Qin, Xiao-Yan Ming, Xian-Bo Zuo, Yu-Wen Diao, Clemens Steegborn, Blair R. Leavitt, Alexei Degterev, Li-Yi Zhang, Jiaoyu Ai, Bei-Lei Liu, Tu-Xiong Huang, Ting-Ting Sarah J. Tabrizi, Donald C. Lo, Marian DiFiglia, Leslie M. Cao, Bin-Bin Tan, Di Xiang, Chui-Mian Zeng, Jing Gong, Thompson, Albena T. Dinkova-Kostova, Qiangfeng Zhang, Sui-Sui Dong, Juan Chen, Haibo Liu, Jian-Lin and Aleksey G. Kazantsev Wu, Robert Z. Qi, Dan Xie, Li-Dong Wang, and Xin-Yuan Guan E4686 HDAC1 links early life stress to E4641 Prognostic and biological significance of the schizophrenia-like phenotypes proangiogenic factor EGFL7 in acute Sanaz Bahari-Javan, Hristo Varbanov, Rashi Halder, Eva Benito, myeloid leukemia Lalit Kaurani, Susanne Burkhardt, Heike Anderson-Schmidt, Ion Dimitrios Papaioannou, Changxian Shen, Deedra Nicolet, Anghelescu, Monika Budde, Roman M. Stilling, Joan Costa, Betina McNeil, Marius Bill, Malith Karunasiri, Matthew H. Burke, Juan Medina, Detlef E. Dietrich, Christian Figge, Here Folkerts, Hatice Gulcin Ozer, Selen A. Yilmaz, Nina Zitzer, Gregory K. Katrin Gade, Urs Heilbronner, Manfred Koller, Carsten Behbehani, Christopher C. Oakes, Damian J. Steiner, Guido Konrad, Sara Y. Nussbeck, Harald Scherk, Carsten Spitzer, Marcucci, Bayard L. Powell, Jonathan E. Kolitz, Thomas H. Sebastian Stierl, Judith Sto¨ckel, Andreas Thiel, Martin von Carter, Eunice S. Wang, Krzysztof Mro´zek, Carlo M. Croce, Hagen, Jo¨rg Zimmermann, Antje Zitzelsberger, Sybille Michael A. Caligiuri, Clara D. Bloomfield, Ramiro Garzon, Schulz, Andrea Schmitt, Ivana Delalle, Peter Falkai, Thomas G. and Adrienne M. Dorrance Schulze, Alexander Dityatev, Farahnaz Sananbenesi, and Andre´ Fischer MICROBIOLOGY 5886 Applying gene regulatory network logic to the 5906 Mechanosensing of shear by Pseudomonas aeruginosa evolution of social behavior leads to increased levels of the cyclic-di-GMP Nicole M. Baran, Patrick T. McGrath, and J. Todd Streelman signal initiating biofilm development 5894 Syringe-injectable mesh electronics integrate seamlessly Christopher A. Rodesney, Brian Roman, Numa Dhamani, with minimal chronic immune response in the brain Benjamin J. Cooley, Ahmed Touhami, and Vernita D. Gordon Tao Zhou, Guosong Hong, Tian-Ming Fu, Xiao Yang, Thomas G. 6098 Visualization and characterization of individual type III Schuhmann, Robert D. Viveros, and Charles M. Lieber protein secretion machines in live bacteria 6116 Prediction of disease activity in models of multiple 章永登 Yongdeng Zhang ( ), Marı´a Lara-Tejero, Jo¨rg Bewersdorf, sclerosis by molecular magnetic resonance imaging and Jorge E. Gala´n of P-selectin 6104 The pentameric complex drives immunologically Antoine Philippe Fournier, Aure´lien Quenault, Sara Martinez de covert cell–cell transmission of wild-type Lizarrondo, Maxime Gauberti, Gilles Defer, Denis Vivien, human cytomegalovirus Fabian Docagne, and Richard Macrez Isa Murrell, Carmen Bedford, Kristin Ladell, Kelly L. Miners, 6122 Changes in perceptual sensitivity related to spatial David A. Price, Peter Tomasec, Gavin W. G. Wilkinson, cues depends on subcortical activity and Richard J. Stanton Lee P. Lovejoy and Richard J. Krauzlis 6110 Unique clade of alphaproteobacterial endosymbionts 6127 Learned response sequences in cerebellar induces complete cytoplasmic incompatibility in the Purkinje cells coconut beetle Dan-Anders Jirenhed, Anders Rasmussen, Fredrik Johansson, Shun-ichiro Takano, Midori Tuda, Keiji Takasu, Naruto Furuya, and Germund Hesslow Yuya Imamura, Sangwan Kim, Kosuke Tashiro, Kazuhiro Iiyama, Matias Tavares, and Acacio Cardoso Amaral PLANT BIOLOGY NEUROSCIENCE 6133 Wild tobacco genomes reveal the evolution of E4648 Selective lowering of synapsins induced by oligomeric nicotine biosynthesis α-synuclein exacerbates memory deficits Shuqing Xu, Thomas Brockmo¨ller, Aura Navarro-Quezada, Megan E. Larson, Susan J. Greimel, Fatou Amar, Michael Heiner Kuhl, Klaus Gase, Zhihao Ling, Wenwu Zhou, Christoph LaCroix, Gabriel Boyle, Mathew A. Sherman, Hallie Schley, Kreitzer, Mario Stanke, Haibao Tang, Eric Lyons, Priyanka Camille Miel, Julie A. Schneider, Rakez Kayed, Fabio Benfenati, Pandey, Shree P. Pandey, Bernd Timmermann, Emmanuel Michael K. Lee, David A. Bennett, and Sylvain E. Lesne´ Gaquerel, and Ian T. Baldwin

Contents PNAS u June 6, 2017 u vol. 114 u no. 23 u vii Downloaded by guest on September 25, 2021 PSYCHOLOGICAL AND COGNITIVE SCIENCES CORRECTIONS (ONLINE ONLY) 6139 Emergence of categorical face perception after extended early-onset blindness APPLIED PHYSICAL SCIENCES Tapan K. Gandhi, Amy Kalia Singh, Piyush Swami, Suma Ganesh, E4695 Structure and mechanics of aegagropilae and Pawan Sinha fiber network Gautier Verhille, Se´bastien Moulinet, Nicolas Vandenberghe, Mokhtar Adda-Bedia, and Patrice Le Gal SYSTEMS BIOLOGY 5792 Logical modeling of lymphoid and myeloid cell PHYSIOLOGY, BIOPHYSICS AND COMPUTATIONAL BIOLOGY specification and transdifferentiation E4696 Direct visualization of the arterial wall water Samuel Collombet, Chris van Oevelen, Jose Luis permeability barrier using CARS microscopy Sardina Ortega, Wassim Abou-Jaoude´, Bruno Di Bertrand M. Lucotte, Chloe Powell, Jay R. Knutson, Christian A. Stefano, Morgane Thomas-Chollier, Thomas Graf, Combs, Daniela Malide, Zu-Xi Yu, Mark Knepper, Keval D. Patel, and Denis Thieffry Anna Pielach, Errin Johnson, Lyudmyla Borysova, Kim A. Dora, 5862 Assessing regulatory information in developmental and Robert S. Balaban gene regulatory networks Isabelle S. Peter and Eric H. Davidson ix Subscription Form

viii u www.pnas.org Contents Downloaded by guest on September 25, 2021