1 UPLC PEER-REVIEWED JOURNAL PUBLICATIONS (2004 – Present

UPLC PEER-REVIEWED JOURNAL PUBLICATIONS (2004 – Present) The publications below have been generated by Waters customers and Waters scientists and collaborators. Each Waters® ACQUITY UPLC® System reference listed below, where available, has its own unique DOI (Digital Object Identifier) tag. The DOI System is used to uniquely identify digital publications by providing current information about where they can be found on the Internet. Click on each link, or go to http://dx.doi.org/ and type in the DOI tag below to get more information about these publications. The articles have been assigned one of the following subject headings: CLINICAL, DRUGS IN PLASMA & URINE, ENVIRONMENTAL, FOOD, LIFE SCIENCES, METABOLISM, NATURAL PRODUCTS, PHARMACEUTICALS and THEORETICAL. The articles are filed by publication date and first author’s last name.

CHEMICALS Zhao Y, Jia L, Yang H, Wang J, Zhang P, Li R, Gong M, Luo S, 2013 Liu S, Xiao X. Influence of nonpolar substances on the extraction efficiency Isella F, Canellas E, Bosetti O, Nerin C. of six alkaloids in zoagumhwan investigated by ultra Migration of non intentionally added substances from performance liquid chromatography and photodiode array adhesives by UPLC-Q-TOF/MS and the role of EVOH to avoid detection. migration in multilayer packaging materials. Molecules. 2012 Nov 22;17(12):13844-55. J Mass Spectrom. 2013 Apr;48(4):430-7. DOI: 10.3390/molecules171213844 DOI: 10.1002/jms.3165

Miyoshi N, Yonemochi T, Tomono S, Fukutomi R, Nakamura Y, Ohshima H. Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells. Anal Biochem. 2012 Oct 15;429(2):124-31. DOI: 10.1016/j.ab.2012.07.018

Zhou SS, Ma ZC, Liang QD, Wang YG, Tan HL, Xiao CR, Sun H, Wang M, Zhang A, Ni B, Dong H, Wang X. Zhang BL, Gao Y. UPLC-Q-TOF-HDMS Analysis of Constituents in the Root of UPLC/Q-TOF-MS-based chemical profiling approach to Two Kinds of Aconitum Using a Metabolomics Approach. evaluate the chemical constitution of Radix Aconiti Lateralis Phytochem Anal. 2012 Dec 6. Preparata in the process of decoction. DOI: 10.1002/pca.2407 Zhong Xi Yi Jie He Xue Bao. 2012 Aug;10(8):894-900. Chinese.

DOI: 10.3736/jcim20120810 Willison SA.

Wipe selection for the analysis of surface materials containing chemical warfare agent nitrogen mustard degradation Aznar M, Rodriguez-Lafuente A, Alfaro P, Nerin C. products by ultra-high pressure liquid chromatography- UPLC-Q-TOF-MS analysis of non-volatile migrants from new tandem mass spectrometry. active packaging materials. J Chromatogr A. 2012 Nov 14. pii: S0021-9673(12)01713-X. Anal Bioanal Chem. 2012 Jul 27 DOI: 10.1016/j.chroma.2012.11.013 DOI: 10.1007/s00216-012-6247-5

Shang E, Zhu Z, Liu L, Tang Y, Duan JA.

UPLC-QTOF-MS with chemical profiling approach for rapidly Yoon KD, Yamamoto K, Ueda K, Zhou J, Sparrow JR. evaluating chemical consistency between traditional and A novel source of methylglyoxal and glyoxal in retina: dispensing granule decoctions of Tao-Hong-Si-Wu decoction. implications for age-related macular degeneration. Chem Cent J. 2012 Nov 24;6(1):143. PLoS One. 2012;7(7):e41309. Epub 2012 Jul 19 DOI: 10.1186/1752-153X-6-143 DOI:10.1371/journal.pone.0041309

CLINICAL 2013

Yu B, Ruan M, Cui XB, Guo JM, Xu L, Dong XP. Effects of borneol on the pharmacokinetics of geniposide in cortex, hippocampus, hypothalamus and striatum of conscious rat by simultaneous brain microdialysis coupled with UPLC-MS. J Pharm Biomed Anal. 2013 Apr 15;77:128-32. DOI: 10.1016/j.jpba.2013.01.017

2011 Tummala M, Chacon A, Chess EK, Lee SM, Hu P. Pertussis toxoid structure: A collaboration and comparison of Potenza M, Sabatino G, Giambi F, Rosi L, Papini AM, Dei L. two-dimensional liquid chromatography-tandem mass Analysis of egg-based model wall paintings by use of an spectrometry, ultraperformance liquid chromatography-mass innovative combined dot-ELISA and UPLC-based approach. spectrometry(E), and capillary liquid chromatography-matrix- Anal Bioanal Chem. 2012 May 22. assisted laser desorption ionization-tandem mass DOI: 10.1007/s00216-012-6049-9 spectrometry. Anal Biochem. 2013 Jun 1;437(1):40-2. DOI: 10.1016/j.ab.2013.03.006 Zhu N, Gu L, Yuan H, Lou Z, Wang L, Zhang X.

Degradation pathway of the naphthalene azo dye intermediate 1-diazo-2- naphthol-4-sulfonic acid using

Fenton's reagent.

Water Res. 2012 Aug;46(12):3859-67.

DOI: 10.1016/j.watres.2012.04.038

Kuhn J, Vollmer T, Martin C, Hendig D, Knabbe C. Fast and sample cleanup-free measurement of nicotine and cotinine by stable isotope dilution ultra-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2012 May 3. DOI: 10.1016/j.jpba.2012.04.036

Noguerol-Cal R, López-Vilariño JM, González-Rodríguez MV, 2012 Barral-Losada L. Effect of several variables in the polymer toys additive Gold H, Mirzaian M, Dekker N, et al migration to saliva. Quantification of Globotriaosylsphingosine in Plasma and Talanta. 2011 Sep 30;85(4):2080-8. Urine of Fabry Patients by Stable Isotope Ultraperformance DOI: 10.1016/j.talanta.2011.07.035 Liquid Chromatography-Tandem Mass Spectrometry. Clin Chem. 2012 Dec 12. DOI: 10.1373/clinchem.2012.192138

Irving GR, Howells LM, Sale S et al Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration - a clinical pilot study including assessment of patient acceptability. Cancer Prev Res (Phila). 2012 Dec 11. DOI: 10.1158/1940-6207.CAPR-12-0281

Fang W, Lv P, Geng X, Shang E, Yang Q, Sha L, Li Y. Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation. Neurochem Int. 2012 Nov 8. pii: S0197-0186(12)00349-X. DOI: 10.1016/j.neuint.2012.10.012

Di Gangi IM, Pirillo P, Carraro S, Gucciardi A, Naturale M, Ayciriex S, Regazzetti A, Gaudin M, Prost E, Dargère D, Baraldi E, Giordano G. Massicot F, Auzeil N, Laprévote O. Online trapping and enrichment ultra performance liquid Development of a novel method for quantification of sterols chromatography-tandem mass spectrometry method for and oxysterols by UPLC-ESI-HRMS: application to a sensitive measurement of "arginine-asymmetric neuroinflammation rat model. dimethylarginine cycle" biomarkers in human exhaled breath Anal Bioanal Chem. 2012 Sep 27. condensate. DOI: 10.1007/s00216-012-6396-6 Anal Chim Acta. 2012 Nov 19;754:67-74. DOI: 10.1016/j.aca.2012.09.032 Arellano C, Gandia P, Lafont T, Jongejan R, Chatelut E.

Determination of unbound fraction of imatinib and N- Owen LJ, Keevil BG. desmethyl imatinib, validation of an UPLC-MS/MS assay and Testosterone measurement by liquid chromatography tandem ultrafiltration method. mass spectrometry: the importance of internal standard J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct choice. 15;907:94-100. Ann Clin Biochem. 2012 Nov;49(Pt 6):600-2. DOI: 10.1016/j.jchromb.2012.09.007 DOI: 10.1258/acb.2012.012037

Cataldi TR, Bianco G, Fonseca J, Schmitt-Kopplin P.

Perceiving the chemical language of Gram-negative bacteria: Pruthi S, Yang L, Sandhu NP, Ingle JN, Beseler CL, Suman listening by high-resolution mass spectrometry. VJ, Cavalieri EL, Rogan EG. Anal Bioanal Chem. 2012 Sep 18. Evaluation of serum estrogen-DNA adducts as potential DOI: 10.1007/s00216-012-6371-2 biomarkers for breast cancer risk.

J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):73-9. Owen LJ, Keevil BG. DOI: 10.1016/j.jsbmb.2012.02.002 Testosterone measurement by liquid chromatography tandem mass spectrometry: the importance of internal standard choice. Petteys BJ, Graham KS, Parnás ML, Holt C, Frank EL. Ann Clin Biochem. 2012 Sep 4. Performance characteristics of an LC-MS/MS method for the DOI: 10.1258/acb.2012.012037 determination of plasma metanephrines. Clin Chim Acta. 2012 Oct 9;413(19-20):1459-65. DOI: 10.1016/j.cca.2012.06.006 Fung FH, Tang JC, Hopkins JP, Dutton JJ, Bailey LM, Davison AS. Lostia AM, Vicente JL, Cowan DA. Measurement of teicoplanin by liquid chromatography-tandem Measurement of Ethyl Glucuronide, Ethyl Sulphate and Their mass spectrometry: development of a novel method. Ratio in the Urine and Serum of Healthy Volunteers after Two Ann Clin Biochem. 2012 Sep;49(Pt 5):475-81. Doses of Alcohol. DOI: 10.1258/acb.2012.011257 Alcohol Alcohol. 2012. DOI: 10.1093/alcalc/ags108 Fung FH, Tang JC, Hopkins JP, Dutton JJ, Bailey LM, Davison

AS. Sun L, Li H, Willson K, Breidinger S, Rizk ML, Wenning L, Measurement of teicoplanin by liquid chromatography-tandem Woolf EJ. mass spectrometry: development of a novel method. Ultrasensitive Liquid Chromatography-Tandem Mass Ann Clin Biochem. 2012 Aug 8. Spectrometric Methodologies for Quantification of Five HIV-1 DOI: 10.1258/acb.2012.011257 Integrase Inhibitors in Plasma for a Microdose Clinical Trial. Anal Chem. 2012 Oct 16;84(20):8614-21. DOI: 10.1021/ac301581h Miyoshi N, Yonemochi T, Tomono S, Fukutomi R, Nakamura

Y, Ohshima H. Arellano C, Gandia P, Lafont T, Jongejan R, Chatelut E. Development and application of a method for identification of Determination of unbound fraction of imatinib and N- isothiocyanate-targeted molecules in colon cancer cells. desmethyl imatinib, validation of an UPLC-MS/MS assay and Anal Biochem. 2012 Jul 24. ultrafiltration method. DOI: 10.1016/j.ab.2012.07.018 J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:94-100. DOI: 10.1016/j.jchromb.2012.09.007 Gucciardi A, Pirillo P, Di Gangi IM, Naturale M, Giordano G. A rapid UPLC-MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening. Anal Bioanal Chem. 2012 Aug;404(3):741-51. DOI: 10.1007/s00216-012-6194-1

Sluiter W, van den Bosch JC, Goudriaan DA, van Gelder CM, de Vries JM, Huijmans JG, Reuser AJ, van der Ploeg AT, Ruijter GJ. Graça G, Goodfellow BJ, Barros AS, Diaz S, Duarte IF, Rapid ultraperformance liquid chromatography-tandem mass Spagou K, Veselkov K, Want EJ, Lindon JC, Carreira spectrometry assay for a characteristic glycogen-derived tetrasaccharide in pompe disease and other glycogen storage IM, Galhano E, Pita C, Gil AM. diseases. UPLC-MS metabolic profiling of second trimester Clin Chem. 2012 Jul;58(7):1139-47. amniotic fluid and maternal urine and comparison with DOI: 10.1373/clinchem.2011.17831 NMR spectral profiling for the identification of pregnancy disorder biomarkers. Mol Biosyst. 2012. Gottas A, Oiestad EL, Boix F, Ripel A, Thaulow CH, Pettersen DOI: 10.1039/C2MB05424H BS, Vindenes V, Morland J. Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass spectrometry. J Pharmacol Toxicol Methods. 2012 Jul;66(1):14-21. DOI: 10.1016/j.vascn.2012.04.009

Borude P, Edwards G, Walesky C, Li F, Ma X, Kong B,

Guo GL, Apte U. Hepatocyte specific deletion of farnesoid X receptor delays, but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology. 2012 Jun 22. DOI: 10.1002/hep.25918

Karim L, Vashishth D.

Heterogeneous glycation of cancellous bone and its association with bone quality and fragility. PLoS One. 2012;7(4):e35047. 2011 DOI: 10.1371/journal.pone.0035047

Kozakai K, Yamada Y, Oshikata M, Kawase T, Suzuki Devenport NA, Reynolds JC, Parkash V, Cook J, E, Haramaki Y, Taniguchi H. Weston DJ, Creaser CS. Reliable High-Throughput Method for Inhibition Assay Determination of free desmosine and isodesmosine as of 8 Cytochrome P450 Isoforms Using Cocktail of Probe urinary biomarkers of lung disorder using ultra Substrates and Stable Isotope-Labeled Internal performance liquid chromatography-ion mobility-mass Standards. spectrometry. Drug Metab Pharmacokinet. 2012 Apr 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 DOI: 10.1002/rcm.6224 Dec 15;879(32):3797-801. DOI: 10.1016/j.chromb.2011.10.016

van der Ham M, Albersen M, de Koning TJ, et al. Schloms L, Storbeck KH, Swart P, Gelderblom WC, Swart AC. Quantification of vitamin B6 vitamers in human The influence of Aspalathus linearis (Rooibos) and cerebrospinal fluid by ultra performance liquid dihydrochalcones on adrenal steroidogenesis: Quantification chromatography-tandem mass spectrometry. of steroid intermediates and end products in H295R cells. Anal Chim Acta. 2012 Jan 27;712:108-14. J Steroid Biochem Mol Biol. 2011 Nov 12. DOI: 10.1016/j.aca.2011.11.018 DOI: 10.1016/j.jsbmb.2011.11.003

Xue C, Jiang S, Guo J, Qian D, Duan JA, Shang E. Screening for in vitro metabolites of Abelmoschus manihot extract in intestinal bacteria by ultra-performance liquid

chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Dec 15;879(32):3901-8. DOI: 10.1016/j.jchromb.2011.10.043 4

Bouchet S, Chauzit E, Ducint D, Castaing N, Canal-Raffin M, Moore N, Titier K, Molimard M. Zvejniece L, Svalbe B, Veinberg G, Grinberga S, Vorona M, Simultaneous determination of nine tyrosine kinase inhibitors Kalvinsh I, Dambrova M. by 96-well solid-phase extraction and ultra performance Investigation into stereoselective pharmacological activity of LC/MS-MS. phenotropil. Clin Chim Acta. 2011 Feb 21. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12. doi: DOI: 10.1016/j.cca.2011.02.023 10.1111/j.1742-7843.2011.00742.x. DOI: 10.1111/j.1742-7843.2011.00742.x

Jamey C, Tracqui A, Ludes B. King CL, Ramachandran S, Chaney SG, et al Sexual abuse and anti-wrinkle cream: Evidence from Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) octocrylene. and -d(ApG) DNA adducts in HCT116 cells. Forensic Sci Int. 2011 Mar 1. Cancer Chemother Pharmacol. 2011 Oct 4. DOI: 10. 1016/j.forsciint.2011.02.012 DOI: 10.1007/s00280-011-1744-3 Kronstrand R, Brinkhagen L, Nyström FH Ethyl glucuronide in human hair after daily consumption of 16 Dalsgaard PW, Rasmussen BS, Müller IB, Linnet K. or 32g of ethanol for 3 months. Toxicological screening of basic drugs in whole blood Forensic Sci Int. 2011 Feb 28. using UPLC-TOF-MS. DOI: 10.1016/j.forsciint.2011.01.044 Drug Test Anal. 2011 Sep 13. DOI: 10.1002/dta.303 Min JZ, Hatanaka S, Yu HF, Higashi T, Inagaki S, Toyo'oka T Determination of dl-amino acids, derivatized with R(-)-4-(3- Horvath TD, Matthews NI, Stratton SL, Mock DM, Boysen G. isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)- Measurement of 3-hydroxyisovaleric acid in urine from 2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC- marginally biotin-deficient humans by UPLC-MS/MS. ESI-TOF-MS. Anal Bioanal Chem. 2011 Sep 3. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Feb 13. DOI: N/A DOI: 10.1016/j.jchromb.2011.02.016

Stepman HC, Vanderroost A, Stöckl D, Thienpont LM. Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin LW, Bonkovsky HL. D(3) in serum of infants and adults. Effects of a single dose of oral iron on hepcidin concentrations Clin Chem Lab Med. 2011 Feb;49(2):253-6. in human urine and serum analyzed by a robust LC-MS/MS DOI: 10.1515/CCLM.2011.050 method. Clin Chim Acta. 2011 Aug 16. DOI: 10.1016/j.cca.2011.08.014

Alodaib A, Carpenter K, Wiley V, Sim K, Christodoulou J,

Wilcken B.

An improved ultra performance liquid chromatography- tandem mass spectrometry method for the determination of alloisoleucine and branched chain amino acids in dried blood samples.

Ann Clin Biochem. 2011 Jul 20. [Epub ahead of print]

DOI: N/A

2010 Strathmann FG, Laha TJ, Hoofnagle AN. Quantification of 1{alpha},25-Dihydroxy Vitamin D by Blonk MI, van der Nagel BC, Smit LS, Mathot RA. Immunoextraction and Liquid Chromatography/Tandem Mass Quantification of levetiracetam in plasma of neonates by ultra Spectrometry. performance liquid chromatography-tandem mass Clin Chem. 2011 Jul 18. [Epub ahead of print] spectrometry. DOI: N/A J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 1;878(7-8):675-681. König S. DOI: 10.1016/j.jchromb.2010.01.037 Urine molecular profiling distinguishes health and disease: new methods in diagnostics? Focus on UPLC-MS. Expert Rev Mol Diagn. 2011 May;11(4):383-91. DOI: 10.1586/erm.11.13 5

Guo L, Wu H, Yue H, Lin S, Lai Y, Cai Z. A novel and specific method for the determination of 2009 aristolochic acid-derived DNA adducts in exfoliated urothelial Elens L, Veriter S, Di Fazio V, Vanbinst R, Boesmans D, cells by using ultra performance liquid chromatography-triple Wallemacq P, Haufroid V quadrupole mass spectrometry. Quantification of 8 HIV-protease inhibitors and 2 J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 4. nonnucleoside reverse transcriptase inhibitors by ultra- DOI: 10.1016/j.jchromb.2010.11.035 performance liquid chromatography with diode array detection. Ko Dae-Hyun; Jun Sun-Hee; Park Hyung-Doo; Song Sang Clin Chem. 2009 Jan;55(1):170-4. Epub 2008 Nov 21. Hoon; Park Kyoung Un; Kim Jin Q; Song Young-Han; Song DOI: 10.1373/clinchem.2008.108647 Junghan Multiplex enzyme assay for galactosemia using ultraperformance liquid chromatography-tandem mass spectrometry. Ming DS, Heathcote J. Clinical chemistry May 2010, 56 (5) p764-71. Therapeutic drug monitoring of clozapine and norclozapine in DOI: N/A human serum using ultra-performance liquid chromatography- tandem mass spectrometry J Anal Toxicol. 2009 May;33(4):198-203 Krüger R, Vogeser M, Burghardt S, Vogelsberger R, Lackner DOI: N/A KJ.

Impact of glucuronide interferences on therapeutic drug Ozalp A, Barroso B. monitoring of posaconazole by tandem mass spectrometry. Simultaneous quantitative analysis of N-acylethanolamides in Clin Chem Lab Med. 2010 Dec;48(12):1723-31. Epub 2010 clinical samples. Aug 13. Anal Biochem. 2009 Dec 1;395(1):68-76. DOI: 10.1515/CCLM.2010.333 DOI: 10.1016/j.ab.2009.08.005

Schwarz E, Liu A, Randall H, Haslip C, Keune F, Murray M, Shimada K, Kawase M, Shibahara N, Nakamura Y, Saito T, Longo N, Pasquali M Takahashi K. Use of Steroid Profiling by UPLC-MS/MS as a Second Tier Test in Newborn Screening for Congenital Adrenal Hyperplasia: the The relation between clinical effects of Tokishakuyakusan and Utah experience. the identity of Paeonia lactiflora materials. Pediatr Res. 2009 Apr 22. J Ethnopharmacol. 2010 Aug 14. DOI: N/A DOI: 10.1016/j.jep.2010.08.023

Stepman HC, Vanderroost A, Stöckl D, Thienpont LM. Waterval WA, Scheijen JL, Ortmans-Ploemen MM, Habets- Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin van der Poel CD, Bierau J. D(3) in serum of infants and adults. Quantitative UPLC-MS/MS analysis of underivatised amino Clin Chem Lab Med. 2010 Dec 14. [Epub ahead of print] acids in body fluids is a reliable tool for the diagnosis and DOI: N/A follow-up of patients with inborn errors of metabolism. Clin Chim Acta. 2009 Jun 24. Van Schooneveld T, Swindells S, Nelson SR, Robbins BL, DOI: 10.1016/j.cca.2009.06.023 Moore R, Fletcher CV.

Clinical evaluation of a dried blood spot assay for atazanavir.

Antimicrob Agents Chemother. 2010 Oct;54(10):4124-8.

DOI: N/A

Zahid M, Saeed M, Ali MF, Rogan EG, Cavalieri EL.N- acetylcysteine blocks formation of cancer-initiating estrogen-

DNA adducts in cells.

Free Radic Biol Med. 2010 Aug 1;49(3):392-400.

DOI: 10.1016/j.freeradbiomed.2010.04.028

2008

Licea-Perez H, Wang S, Szapacs ME, Yang E.

Development of a highly sensitive and selective UPLC/MS/MS

method for the simultaneous determination of testosterone

and 5 alpha-dihydrotestosterone in human serum to support

testosterone replacement therapy for hypogonadism.

Steroids. 2008 Jul ; 73(6):601-10. Epub 2008 Feb 2

DOI: 10.1016/j.steroids.2008.01.018

Stephanson N, Helander A, Beck O. Alcohol biomarker analysis: simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatography-tandem mass spectrometry. J Mass Spectrom. 2007 Jun 12;42(7):940-949 [Epub ahead of print] DOI: 10.1002/jms.1231

Wang D, Zhang M. Rapid quantitation of testosterone hydroxyl metabolites by ultra-performance liquid chromatography and mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 29; [Epub ahead of print] DOI: 10.1016/j.jchromb.2007.05.022

2007 2006 Bendroth P, Kronstrand R, Helander A, Greby J, Stephanson Apollonio LG, Pianca DJ, Whittall IR, Maher WA, Kyd JM. N, Krantz P. A demonstration of the use of ultra-performance liquid Comparison of ethyl glucuronide in hair with chromatography-mass spectrometry [UPLC/MS] in the phosphatidylethanol in whole blood as post-mortem markers determination of amphetamine-type substances and ketamine of alcohol abuse. Forensic Sci Int. 2007 Nov 13; [Epub ahead for forensic and toxicological analysis. of print] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May DOI: 10.1016/j.forsciint.2007.09.012 19;836(1-2):111-5. DOI: 10.1016/j.jchromb.2006.03.045 Englmann M, Fekete A, Gebefugi I, Schmitt-Kopplin P. The dosage of small volumes for chromatographic Apollonio LG, Whittall IR, Pianca DJ, Kyd JM, Maher WA. quantifications using a drop-on-demand dispenser system. Product ion mass spectra of amphetamine-type substances, Anal Bioanal Chem. 2007 Jun 5; [Epub ahead of print] designer analogues, and ketamine using ultra-performance DOI: 10.1007/s00216-007-1335-7 liquid chromatography/tandem mass spectrometry. Li L, Pabbisetty D, Carvalho P, Avery MA, Avery BA. Rapid Commun Mass Spectrom. 2006 Jun 29;20(15):2259- Analysis of CoQ(10) in rat serum by ultra-performance liquid 64. chromatography mass spectrometry after oral administration. DOI: 10.1002/rcm.2589 J Pharm Biomed Anal. 2008 Jan 7;46(1):137-42. Epub 2007 Oct 23. DOI: 10.1016/j.jpba.2007.10.019

Lindeman NI, Freeto SM, Jarolim PA. Immunosuppressant monitoring can be performed by UPLC- tandem mass spectrometry in half the time needed for conventional HPLC-Tandem Mass Spectrometry, with comparable analytical performance. Clin Chim Acta. 2008 Feb;388(1-2):207-10. Epub 2007 Oct 30. DOI: 10.1016/j.cca.2007.10.025

Kaufmann A, Butcher P, Maden K, Widmer M. Ultra-performance liquid chromatography coupled to time of flight mass spectrometry (UPLC-TOF): a novel tool for multiresidue screening of veterinary drugs in urine. Anal Chim Acta. 2007 Mar 14;586(1-2):13-21. Epub 2006 Oct 26. DOI: 10.1016/j.aca.2006.10.026

Kawanishi H, Toyo'oka T, Ito K, Maeda M, Hamada T, Fukushima T, Kato M, Inagaki S. Rapid determination of histamine and its metabolites in mice hair by ultra-performance liquid chromatography with time- DRUGS IN PLASMA AND URINE of-flight mass spectrometry. 2013 J Chromatogr A. 2006 Nov 3;1132(1-2):148-56. DOI: 10.1016/j.chroma.2006.07.086 Liu P, Li Z, Qian D, Li W, Shang EX, Duan JA. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma Nielen MW, Bovee TF, van Engelen MC, Rutgers P, Hamers by UPLC-MS/MS and its application to pharmacokinetics. AR, van Rhijn JH, Hoogenboom LR. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr Urine testing for designer steroids by liquid chromatography 20;929C:63-69. with androgen bioassay detection and electrospray DOI: 10.1016/j.jchromb.2013.04.022 quadrupole time-of-flight mass spectrometry identification. Anal Chem. 2006 Jan 15;78(2):424-31. DOI: 10.1021/ac051317q Juenke JM, Brown PI, Urry FM, Johnson-Davis KL, McMillin GA. Touber ME, van Engelen MC, Georgakopoulus C, van Rhijn Simultaneous UPLC-MS/MS assay for the detection of the JA, Nielen MW. traditional antipsychotics haloperidol, fluphenazine, Multi-detection of corticosteroids in sports doping and perphenazine, and thiothixene in serum and plasma. veterinary control using high-resolution liquid Clin Chim Acta. 2013 Apr 23;423C:32-34. chromatography/time-of-flight mass spectrometry. DOI: 10.1016/j.cca.2013.04.014 Anal Chim Acta. 2007 Mar 14;586(1-2):137-46. Epub 2006 Oct 5. DOI: 10.1016/j.aca.2006.09.058 Jamalapuram S, Vuppala PK, Abdelazeem AH, McCurdy CR, Avery BA. Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics. Biomed Chromatogr. 2013 Apr 5. DOI: 10.1002/bmc.2901

Zhu Y, Feng Y, Shen L, Xu D, Wang B, Ruan K, Cong W. Effect of metformin on the urinary metabolites of diet- induced-obese mice studied by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-TOF/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr 15;925:110-6. DOI: 10.1016/j.jchromb.2013.02.040

Patel DP, Sharma P, Sanyal M, Shrivastav PS. SPE-UPLC-MS/MS method for sensitive and rapid 2005 determination of aripiprazole in human plasma to support a Lurie IS. bioequivalence study. High-performance liquid chromatography of seized drugs at J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr elevated pressure with 1.7 µm hybrid C18 stationary phase 15;925:20-5. columns. DOI: 10.1016/j.jchromb.2013.02.022 J Chromatogr A. 2005 Dec 30;1100(2):168-75. DOI: 10.1016/j.chroma.2005.09.054

Kaabia Z, Dervilly-Pinel G, Hanganu F, Cesbron N, Bichon E, Popot MA, Bonnaire Y, Le Bizec B. Ultra high performance liquid chromatography/tandem mass Kim TK, Kim IS, Hong SH, Choi YK, Kim H, Yoo HH. spectrometry based identification of steroid esters in serum Determination of dapoxetine in rat plasma by ultra- and plasma: an efficient strategy to detect natural steroids performance liquid chromatography-tandem mass abuse in breeding and racing animals. spectrometry. J Chromatogr A. 2013 Apr 5;1284:126-40. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May DOI: 10.1016/j.chroma.2013.02.010 1;926:42-6. DOI: 10.1016/j.jchromb.2013.03.002

Berg T, Jørgenrud B, Strand DH. Determination of buprenorphine, fentanyl and LSD in whole Xia B, Liu X, Gu YC, Zhang ZH, Wang HY, Ding LS, Zhou Y. blood by UPLC-MS-MS. Non-Target Screening of Veterinary Drugs Using Tandem J Anal Toxicol. 2013 Apr;37(3):159-65. Mass Spectrometry on SmartMass. DOI: 10.1093/jat/bkt005 J Am Soc Mass Spectrom. 2013 May;24(5):789-93. DOI: 10.1007/s13361-013-0578-0

Qi W, Zhao Q, Liu H, Jiang J, Chen X, Hu P. Janzen N, Steuerwald U, Sander S, Terhardt M, Peter M, Determination of nicousamide in human plasma by liquid Sander J. chromatography-tandem mass spectrometry. UPLC-MS/MS analysis of C5-acylcarnitines in dried blood J Pharm Biomed Anal. 2013 Apr 15;77:158-62. spots. DOI: 10.1016/j.jpba.2013.01.025 Clin Chim Acta. 2013 Jun 5;421:41-5. DOI: 10.1016/j.cca.2013.03.001

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Yu Z, Han C, Yan X, Li X, Jiang G, Yan Y. Rapid Characterization of Wheat Low Molecular Weight Glutenin Subunits by Ultraperformance Liquid Chromatography (UPLC). J Agric Food Chem. 2013 Apr 17. DOI: N/A

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Cui L, Sun E, Zhang Z, Qian Q, Tan X, Xu F, Jia X.

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Gasperotti Mattia; Masuero Domenico; Vrhovsek Urska; Guella Graziano; Mattivi Fulvio Profiling and accurate quantification of Rubus ellagitannins and ellagic acid conjugates using direct UPLC -Q-TOF HDMS and HPLC-DAD analysis. Kim M, Kim SC, Song KJ, Kim HB, Kim IJ, Song EY, Chun SJ. Journal of agricultural and food chemistry Apr 28 2010, 58 (8) Transformation of carotenoid biosynthetic genes using a p4602-16. micro-cross section method in kiwifruit (Actinidia deliciosa cv. DOI: N/A Hayward).

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Development of a rapid method for the analysis of synthetic

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Kiss B, Bogdan C, Pop A, Loghin F.

A rapid UPLC-MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and

EDDP in human, rat and rabbit plasma.

Talanta. 2012 Sep 15;99:649-59.

DOI: 10.1016/j.talanta.2012.06.070

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