Supplementary table 1 TNM classification of digestive endocrines tumours by ENETS2,3 and UICC1 Stomach Small Bowel Pancreas Appendix Colo-rectal ENETS
T1 Tumor invades Tumor invades Tumor limited to the Tumor ≤1 cm invading T invades mucosa or lamina propria or mucosa or pancreas and submucosa and submucosa (T1a: <1 submucosa and submucosa and T≤2 cm muscularispropria cm, T1b: 1-2 cm) T≤1 cm T ≤1 cm T2 Tumor invades Tumor invades Tumor limited to the Tumor ≤2 cm invading Tumor invades muscularis propria muscularis propria T pancreas and size 2– submucosa, muscularis propria or or subserosa or or T> 1 cm 4 cm muscularis propria size >2 cm T> 1 cm and/or minimally (up to 3 mm) invading subserosa/mesoappe ndix T3 Tumor penetrates - Tumor invades Tumor limited to the Tumor >2 cm and/or Tumor invades serosa pancreas or pancreas and size >4 extensive (more than subserosa/pericolic/p retroperitoneum cm or invading 3 mm) invasion of erirectal fat (duodenum, duodenum or bile duct subserosa/mesoappe ampoula, proximal ndix jéjunum) - Tumor invades subserosa (ileum, distal jé junum) T4 Tumor invades Tumor invades Tumor invading Tumor invades Tumor directly adjacent structures peritoneum/other adjacent organs peritoneum/other invades other organs (stomach, spleen, organs organs/structures colon, adrenal gland) N-regional lymph and/or or the wall of large nodes perforates visceral vessels (celiac axis or peritoneum superior mesenteric artery) UICC T1 Tumor invades Tumor invades Tumor limited to the T≤2 cm(T1a : ≤1 cm, Tumor invades lamina propria or mucosa or pancreas and T1b : >1-2 cm) mucosa or submucosa and submucosa and T≤2 cm submucosa (T1a: <1 T≤1 cm T≤1 cm cm, T1b: 1-2 cm) T2 Tumor invades Tumor invades Tumor limited to the Tumor invades Tumor invades muscularis propria muscularis propria T pancreas and size> 2 caecum or T >2and muscularis propria or or subserosa or T> or T> 1 cm cm <4 cm size >2 cm 1 cm
T3 Tumor penetrates Tumor invades Tumor beyond the Tumor invades ileum Tumor invades serosa pancreas or pancreas but does not or T >4 cm subserosa/pericolic/p retroperitoneum invade celiac axis or erirectal fat (duodenum, superior mesenteric ampoula, proximal artery jejunum) - Tumor invades subserosa (ileum, distal jejunum) T4 Tumor invades Tumor invades Tumor invades celiac Tumor invades Tumor directly adjacent structures peritoneum/other axis or superior peritoneum invades other organs mesenteric artery organs/structures and/or perforates visceral peritoneum
For both classifications
N—regional lymph nodes NX Regional lymph node cannot be assessed N0 No regional lymph node metastasis N1 Regional lymph node metastasis
M—distant metastases MX Distant metastasis cannot be assessed M0 No distant metastases M1a Distant metastasis
References
1.Sobin LH, Gospodarowicz M, Wittekind Ch, editors. UICC (International Union Against Cancer). TNM classification of malignant tumours. 7th ed. New York: Wiley-Blackwell. 2009
2. Rindi G, Klöppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P et al. TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Archiv 2006 449 395–401. (doi:10.1007/s00428-006-0250-1).
3. Rindi G, Klöppel G, Couvelard A, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Archiv 2007 451 757– 762. (doi:10.1007/s00428-007-0452-1).