CAPNS1 Antibody Cat. No.: 22-296

CAPNS1 Antibody

Immunohistochemistry of paraffin-embedded human liver Immunohistochemistry of paraffin-embedded human colon using CAPNS1 antibody cancer using CAPNS1 antibody (22-296) at dilution of 1:100 (40x lens). (22-296) at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human esophageal cancer using CAPNS1 antibody (22-296) at dilution of 1:100 (40x lens).

Specifications

September 30, 2021 1 https://www.prosci-inc.com/capns1-antibody-22-296.html HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion containing a sequence corresponding to amino acids 69-268 IMMUNOGEN: of human CAPNS1 (NP_001740.1).

TESTED APPLICATIONS: IF, IHC, WB

WB: ,1:500 - 1:2000

APPLICATIONS: IHC: ,1:50 - 1:100

IF: ,1:50 - 1:100

POSITIVE CONTROL: 1) BT-474

2) U-251MG

3) SKOV3

4) Mouse lung

5) Mouse heart

6) Mouse spleen

PREDICTED MOLECULAR Observed: 28kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: CAPNS1

CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, small subunit 1, CANP small subunit, calcium-activated neutral proteinase small subunit, calcium-dependent ALTERNATE NAMES: small subunit 1, calcium-dependent protease, small subunit, calpain 4, small subunit (30K), calpain regulatory subunit, calpain, small polypeptide, epididymis secretory sperm binding protein

GENE ID: 826

September 30, 2021 2 https://www.prosci-inc.com/capns1-antibody-22-296.html USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This is a member of the calpain small subunit family. are calcium- dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of BACKGROUND: both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on 1. Alternative splicing results in multiple transcript variants.

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 30, 2021 3 https://www.prosci-inc.com/capns1-antibody-22-296.html