Anti-MAPK1 Monoclonal Antibody, Clone 4G9 (DCABH-12287) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-MAPK1 monoclonal antibody, clone 4G9 (DCABH-12287) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Immunogen Recombinant protein corresponding to human MAPK1.

Source/Host Mouse

Species Reactivity Human, Mouse

Clone 4G9

Conjugate Unconjugated

Applications Western Blot (Cell lysate); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections); ELISA; Flow Cytometry

Format Liquid

Size 1 ea

Buffer In ascites (0.03% sodium azide)

Preservative 0.03% Sodium Azide

Storage Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

Warnings This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol MAPK1

Synonyms MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK;

Entrez Gene ID 5594

Protein Refseq NP_002736

UniProt ID P28482

Chromosome Location 22q11.2

Pathway ALK1 signaling events, organism-specific biosystem; ARMS-mediated activation, organism- specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem;

Function ATP binding; DNA binding; MAP kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphatase binding; phosphotyrosine binding; protein binding; protein se

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]