Seminar Series – Week Commencing 8 October 2018 Seminars and Clinical Rounds for Science and Health Across All WAHTN Partner Institutions

Download the new WAHTN App! A new way to connect and view upcoming Seminar Series – Week Commencing 8 October 2018 seminars and clinical rounds for science and health across all WAHTN partner institutions.

Further Name of Presenter Title of Presentation Date Time Venue Seminar Series Information Professor Akihiro Sleep/wakefulness control using 8 October 2018 1:00pm Room 1.81, Anatomy, School of Human CLICK

Yamanaka optogenetics Physiology & Human Biology Sciences HERE

Building North, UWA

Professor Akihiro Behavioural Control Using 8 October 2018 5:00pm G33 Lecture Theatre, Bayliss CLICK RAINE Lecture Series

Yamanaka Optogenetics Building, University of Western HERE Australia

Professor Wallace Improving cancer treatment by 9 October 2018 12:30pm – 1:30pm McCusker Auditorium, Harry CLICK Dean’s Distinguished Langdon preventing chemotherapy-induced Perkins Institute of Medical HERE Lecture Series myelosuppression Research Professor Akihiro Masterclass 10 October 2018 10:00am – 4:00pm Forrest Hall, The University of RAINE Foundation CLICK Yamanaka and Professor Shedding light on optogenetics Western Australia Limited Audience, HERE Yoichiro Otsuka First come first served

Nikhilesh Bappoo and ‘Engineering the placenta: 11 October 2018 12:00pm – 1:00pm McCusker Auditorium, Harry Perkins Seminar Series CLICK Louis Parker Advances in understanding fetal Perkins Institute of Medical HERE growth restriction’ Research ‘Understanding the complex flow patterns of the diseased aorta: A basis for risk quantification and pre-surgical planning’ Dr Joel Stafford The Use of Research Evidence in 12 October 2018 12:00pm – 1:00pm Level 5 , Telethon Kids Seminar Telethon Kids Research CLICK the Health and Education Services Room, Seminars HERE System – Challenges and Future Perth Children’s Hospital Directions Telethon Kids Institute Using REDCap for your Data 12 October 2018 12:30pm – 1:30pm Perth Children’s Hospital, Level Research Skills CLICK Biometrics Team Capture and Management 5, PCH Auditorium Workshop HERE Contact: researcheducationprog

[email protected]

UPCOMING SEMINARS

Anita Denning How to make a research poster 15 October 2018 12:30pm – 1:30pm Joske Room East CLICK SCGH Research Week

HERE

Lam Yun Wah To mend a broken heart, thou 16 October 2018 1:00pm Room 1.81, Anatomy, CLICK School of Human shalt learn from the ladies Physiology & Human Biology HERE Sciences

Building North, UWA

Dr Gretchen Gierach Breast Density and Hormones: 16 October 2018 4:00pm 5th Floor Seminar Room, MRF RPH Medical Research CLICK

Implications for Breast Cancer Building, Rear 50 Murray Street Forum

HERE Etiology and Progression Professor Christobel Grand Round “How to implement 16 October 2018 12:15pm – 1:30pm Joske Rooms https://scgophcg- CLICK Saunders AO and Dr Angela patient reported outcomes in the healthpoint.hdwa.healt HERE Ives real world: measuring what really h.wa.gov.au/directory/ matters to patients and the Research/Pages/Resear

healthcare system” ch-week.aspx.

Perth Cancer Club Cancer Research at the QEII 17 October 2018 4:00pm Seminar Room G24, Harry Perth Cancer Club CLICK Ruth Ganss, Katie Meehan Medical Precinct Perkins Institute of Medical HERE and Terry Johns Research

Professor Peter Thompson History of Research at SCGH 17 October 2018 12:30pm – 1:30pm Joske Room West https://scgophcg- CLICK healthpoint.hdwa.healt HERE h.wa.gov.au/directory/ Research/Pages/Resear ch-week.aspx.

Various Speakers New Investigators Presentations 17 October 2018 1:30pm - onwards Joske Room West https://scgophcg- CLICK healthpoint.hdwa.healt HERE h.wa.gov.au/directory/ Research/Pages/Resear ch-week.aspx. Various Speakers Engaging Staff in Research 18 October 2018 9:00am – 12:00pm Joske Rooms https://scgophcg- CLICK Presentations healthpoint.hdwa.healt HERE h.wa.gov.au/directory/ Research/Pages/Resear ch-week.aspx. Various Speakers Lunch Time Presentation 18 October 2018 12:00pm – 12:30pm Joske Rooms https://scgophcg- CLICK healthpoint.hdwa.healt HERE h.wa.gov.au/directory/ Research/Pages/Resear ch-week.aspx.

Professor Jacques Miller How the thymus has shaped 18 October 2018 12:00pm – 1:00pm McCusker Auditorium, Harry CLICK Perkins Seminar Series Immunology and beyond Perkins Institute of Medical HERE

Research

Various Speakers Precision Public Health 2018 18 – 19 October 2 Day Symposium Esplanade Hotel Fremantle CLICK http://pph2018.com/re 2018 HERE gister/

Tom McBride Early Intervention: Evidence based 19 October 2018 7:30am – 9:30am Telethon Kids Institute Seminar RSVP ESSENTIAL: CLICK decision making for public services Room, Level 5, Perth Children’s https://colab-early- HERE Hospital intervention- event.eventbrite.com. au

Elder/Co-researchers and The Ngulluk Koolunga Ngulluk 19 October 2018 12:00pm – 1:00pm Telethon Kids Institute Seminar Telethon Kids Research CLICK the project team Koort (Our Children, Our Heart) Room, Level 5, Perth Children’s Seminars HERE

project Hospital

Dr Michael Wright with Involving Aboriginal People in 19 October 2018 12:30pm – 1:30pm PCH Auditorium, Level 5, Perth Research Skills CLICK Glenn Pearson Research Children’s Hospital Seminar Series HERE

Research Education

Program Contact: researcheducationprog [email protected]

Andrea Fuller Busting myths about how 22 October 2018 1:00pm Seminar Room 1.81, Anatomy, CLICK School of Human mammals cope with heat – Physiology & Human Biology HERE Sciences

insights from free-living mammals Building North, UWA

International & National Functional High Throughput 24 – 25 October Must John Curtin School of Medical https://www.fhtta.com CLICK Experts Presenting Technologies Australia Meeting 2018 Register Research, ANU, Canberra HERE 2018

Professor Christobel Making your Cancer Research 25 October 2018 12:00pm – 1:00pm McCusker Auditorium, Harry Perkins Seminar Series CLICK Saunders discoveries into better cancer Perkins Institute of Medical HERE

treatments Research

Dr Julie Marsh Statistical Tips for Interpreting 26 October 2018 12:30pm – 1:30pm Perth Children’s Hospital, Level Research Skills CLICK Scientific Claims 5, PCH Auditorium Seminar Series HERE Research Education Program Contact: researcheducationprog [email protected]

Various National & State of the Science in Post-Stroke 16 – 17 November Must ECU 270 Joondalup Drive Contact: Dr Manonita CLICK International Speakers Motor Recovery Symposium 2018 Register Ghosh HERE [email protected] Ecu.edu.au/conference s/post-stroke-2018

Professor Tambet Teesalu, Australian Society of Molecular 20-21 November 2 Day Symposium Harry Perkins Institute of https://asmi2018.word CLICK Assoc Professor Elizabeth Imaging Perth 2018 Scientific 2018 Medical Research press.com/ HERE New, Professor Joon Jung Meeting

Min

Professor Suzanne Health Economics in Clinical Trials 26, 27,& 28 9am – 4pm Harry Perkins (north) QEII researcheducation@re CLICK Robinson & Professor Liz November 2018 tp.org HERE Geelhoed

Symposium of Western Various – Please see flyer 29 - 30 November Must Various – Please see flyer Abstract Submissions: CLICK Australian Neuroscience 2018 Register lindy.fitzgerald@curtin. HERE (SWAN) (Free Registration) edu.au

https://goo.gl/forms/ Queries: – KKjsew2B80Wi6V602 randi.molgaardangel@ perron.uwa.edu.au

RETP Online Courses “Good Clinical Practice (GCP) V.3; A Practical Guide to Critical Appraisal; An Introduction to Health Research; The CLICK To enroll go to Essential of Writing a Research Protocol; Identifying Grant Opportunities; Literature Searching and HERE www.retp.org Management; Health Economics: Application to Research; An Introduction to Immersive Technologies in Healthcare.” International Meeting European Wnt Meeting 2018 12-14 September Communication Center 2018 German Cancer Research CLICK Center (DKFZ) - Heidelberg, HERE Germany

School of Human Sciences

The Head of School, Professor Shane Maloney, invites you to attend the

2018 SECOND SEMESTER, SPECIAL SEMINAR

Title: Sleep/wakefulness control using optogenetics

Presenter: Akihiro Yamanaka, Raine Visiting Professor Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University

When: Monday 8 October 2018 @ 1pm

Venue: Room 1.81, Anatomy, Physiology & Human Biology Building North The University of Western Australia (off Hackett Entrance No. 2)

The Speaker Professor Akihiro Yamanaka leads a team of researchers at the Department of Neuroscience II, Research Institute of Environmental Medicine (RIEM) at Nagoya University, Japan. Professor Yamanaka is a pharmacologist by training but early in his career he developed a strong interest in neuroscience. He has been at the forefront of research on orexin/hypocretin neurons since their discovery in 1998. Using slice patch clamp recording of orexin neurons, and later using optogenetics to control the activity of orexin neurons and associated neurotransmitter pathways, he has unravelled the nature and functionality of the neural network that is involved in the regulation of sleep/wakefulness.

He has published more than 90 papers since obtaining his PhD in 2000, with more than 40% of his papers in high impact journals such as Nature, Science, and Neuron. He has extensively published about the applications and developments of optogenetics technology in the neurosciences.

Optogenetics enables neuroscientists to manipulate the activity of neurons using light. What is the mechanism of optogenetics? What can a neuroscientist reveal using optogenetics? In this seminar, Professor Yamanaka will discuss the impact of optogenetics on neuroscience research, taking as an example the application to neural circuits that regulate animal behaviour.

Abstract: Sleep/wakefulness is a very familiar and interesting physiological phenomenon. However, little is known about its neural regulatory mechanisms, since it has been difficult to manipulate the activity of neurons in vivo. With the development of optogenetics in 2005, it has become possible to control the activity of targeted neurons in vivo. To do this, light activated proteins, such as channelrhodopsin (ChR), can be expressed in the targeted neurons and the delivery of light at an appropriate wavelength then activates those ChR expressing neurons. In this lecture, Prof Yamanaka will discuss the impact of optogenetics on neuroscience research, taking as an example the application to neural circuits that regulate sleep and wakefulness.

PARKING: Enquiries: Coin operated visitor parking is available between Hackett Entrances 1 and 2 and Parkway Christine Page: Phone 6488 7126 Fax 6488 1051 Entrance 4. City of Subiaco controlled riverside parking is also available. Email: [email protected] www.aphb.uwa.edu.au

Raine Visiting Professor Lecture – 8 October 2018 Professor Akihiro Yamanaka Nagoya University, Japan

will present a Raine Lecture entitled: Behavioural Control Using Optogenetics

on Monday 8 October 2018 at 5.00 pm at G33 Lecture Theatre, Bayliss Building, The University of Western Australia

All welcome

Professor Akihiro Yamanaka leads a team of researchers at the Department of Neuroscience II, Research Institute of Environmental Medicine (RIEM) at Nagoya University, Japan. Professor Yamanaka is a pharmacologist by training but early in his career, he developed a strong interest in neurosciences. Professor Yamanaka has been at the forefront of research on orexin/hypocretin neurons since their discovery in 1998. First, using slice patch clamp recording of orexin neurons and later using optogenetics to control the activity of orexin neurons and associated neurotransmitter pathways, Professor Yamanaka has unravelled the nature and functionality of the neural network that is involved in the regulation of sleep/wakefulness. Professor Yamanaka has published more than 90 papers since obtaining his PhD in 2000, with more than 40% of his papers published in high impact journals such as Nature, Science, and Neuron. Professor Yamanaka has extensively published about the applications and developments of optogenetics technology in the neurosciences. Optogenetics enables neuroscientists to manipulate the activity of neurons using light. What is the mechanism of optogenetics? What can a neuroscientist reveal using optogenetics? In this lecture, Professor Yamanaka will discuss the impact of optogenetics on neuroscience research, taking as an example the application to neural circuits that regulate animal behaviour.

University Host: Professor Shane Maloney School of Human Sciences University of Western Australia Telephone: 6488 3394 Email: [email protected]

Dean's Distinguished Lecture Series

Professor Wallace Langdon

Improving cancer treatment by preventing chemotherapy-induced myelosuppression

Date: Tuesday, 9 October 2018 Time: 12:30pm – 1:30pm Venue: McCusker Auditorium, Harry Perkins Institute, QEII campus

Professor Langdon’s research has mainly focused on the analysis of mouse models of tumorigenesis, a direction that was initiated during postdoctoral fellowships at NIH and WEHI investigating haematopoietic tumours. A key outcome from these studies was the discovery of the Cbl oncogene.

Professor Langdon’s laboratory has been continuously funded by NHMRC project grants for 29 years and he has supported other researchers by providing Cbl reagents and mutant mice to 353 labs in 20 countries. Over the past decade his studies of a knock-in mouse with a mutation in the RING finger domain of Cbl have provided a pre-clinical model for investigating leukaemias that are caused by Cbl mutations. These studies identified an inhibitor to the FLT3 receptor tyrosine kinase called quizartinib as an effective treatment. An additional outcome from dosing mice with quizartinib is that it induces the transient quiescence of haematopoietic progenitors, and that this property protects them from a range of cytotoxic drugs. These studies have evolved into the repurposing of quizartinib to prevent chemotherapy-induced myelosuppression. Masterclass Announcement

“Shedding light on optogenetics”

Prof Akihiro Yamanaka from the University of Nagoya (Japan) is visiting UWA as a Raine Visiting Professor. He and Prof Yoichiro Otsuka from Flinders University (South Australia) (see biographies below) will share their experience and expertise of optogenetics, and discuss techniques and practicalities, in an informal Masterclass.

Where: Forest Hall When: Wednesday October 10 from 10 am to 4 pm (light lunch provided)

Limited audience, first come first served.

Please register your interest by emailing Christine Page ([email protected])

Biographies Professor Akihiro Yamanaka leads a team of researchers at the Department of Neuroscience II, Research Institute of Environmental Medicine (RIEM) at Nagoya University, Japan. Professor Yamanaka is a pharmacologist by training but early in his career, he developed a strong interest in neurosciences. Professor Yamanaka has been at the forefront of research on orexin/hypocretin neurons since their discovery in 1998. First, using slice patch clamp recording of orexin neurons and later using optogenetics to control the activity of orexin neurons and associated neurotransmitter pathways, Professor Yamanaka has unravelled the nature and functionality of the neural network that is involved in the regulation of sleep/wakefulness. Professor Yamanaka has published more than 90 papers since obtaining his PhD in 2000, with more than 40% of his papers published in high impact journals such as Nature, Science, and Neuron. Professor Yamanaka has extensively published about the applications and developments of optogenetics technology in the neurosciences.

Prof Yoichiro Otsuka is in the Mary Overton Neuroscience Research Fellow and the head of the Integrative Neuroscience Lab at Centre for Neuroscience at Flinders University. After two years on an International Society of Hypertension Fellowship at the Howard Florey Institute of Experimental Medicine, he spent four years at Kagoshima University from 2009, then was a Visiting Research Fellow in the Department of Neurosciences, Medical University of South Carolina. His background is in biology, physiology and neuroscience, concentrating on brain circuitry controlling essential bodily functions via the autonomic nervous system.

THURSDAY 11 OCTOBER

Nikhilesh Bappoo

PhD Student, Vascular Engineering Laboratory

Harry Perkins Institute of Medical Research

"Engineering the placenta: Advances in understanding fetal growth

restriction"

Nik Bappoo is a PhD student in the Vascular Engineering Laboratory (VascLab) at the Harry Perkins Institute of Medical Research and the School of Engineering at UWA. In 2016, he graduated with a Bachelor of Philosophy (BPhil) degree with First Class Honours majoring in both Engineering Science and Pathology and in 2017, he graduated with a Master of Professional Engineering in Mechanical Engineering, both at UWA. He completed his Honours research project focusing on fetal-placental blood flow under the supervision of Barry Doyle and Caitlin Wyrwoll, which he published in a leading biomedical engineering journal. This work has been well received by the field and is already being cited. In 2017, Nik won the prestigious international Mimics Innovation Award and in 2018 he came 2nd in the Best Student Paper Award in his category at the World Congress of Biomechanics. Nik is also a founding member of the UWA Biomedical Engineering Society and served as President in 2018.

Louis Parker

PhD Student, Vascular Engineering Laboratory

Harry Perkins Institute of Medical Research

"Understanding the complex flow patterns of the diseased aorta: A

basis for risk quantification and pre-surgical planning"

Louis studied Mechanical Engineering at UWA where he first joined the Vascular Engineering Lab for his final year project in 2015 studying common iliac artery aneurysms. He then commenced a PhD in early 2016, continuing his work in aneurysms and setting up a computational framework to study the haemodynamics of aortic dissection. In 2018 he has shared his work with the two major European societies for vascular surgery at their annual meetings in Strasbourg and Valencia as well as the World Congress of Biomechanics in Dublin where he was awarded the Mimics Innovation Award for his work in using computational fluid dynamics to assist in the planning of complex aortic intervention.

12noon to 1.00pm followed by a light lunch

For more information, please contact Louise Winteringham on [email protected]

MCCUSKER AUDITORIUM, HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH, NORTH CAMPUS

Telethon Kids Research Seminars

Invited Speaker Dr Joel Stafford Data Analyst; Human Capability (Tassie Kids Project) Telethon Kids Institute and Tasmanian Government Dept of Education

The Use of Research Evidence in the Health and Education Services System – Challenges and Future Directions

12 October 2018

12noon – 1.00pm

Institute Seminar Room Lvl 5; PCH

A light lunch will be provided at 11:45 for those attending the seminar Research Skills Workshops 2018 Research Education Program Using REDCap for your Data Capture and Management Friday, 12 October 12:30 – 1:30PM

The Telethon Kids Institute’s Biometric team provides access to REDCap for all Telethon Kids, Child and Adolescent Health Services (CAHS), and PCH based researchers.

In this presentation, you will learn how to access REDCap, and where to go if you need further assistance in this area.

This session is open to all researchers, and clinicians and is available at PCH Auditorium, at Hosted Video‐Conference locations, and through your own personal desktop/device with Scopia.

Presented by Matt Cooper, Ali Hollingsworth, and Rakshya Khadka of the Telethon Kids Institute Biometrics Team

Perth Children’s Hospital *Hosted VC Sites Include: PCH Auditorium, Level 5 Child and Adolescent Community Health (Pink or Yellow lifts) Curtin University 15 Hospital Ave, Nedlands Fiona Stanley Hospital Joondalup Health Campus Register Online Lions Eye Institute Royal Perth Hospital

ResearchEducationProgram For more locations, visit: .eventbrite.com ResearchEducationProgram.org Further information: [email protected] *Online via Scopia App ResearchEducationProgram.org and your own PC or Mobile Device

The Research Skills Seminar Series, workshops, and forums, are part of the Research Education Program, Department of Child Health Research, Perth Children’s Hospital, WA Department of Health. Seminars are hosted by WA Department of Health. Government of Western Australia North Metropolitan Health Service Sir Charles Gairdner Osborne Park Health Care Group

Join us for: for a series of presentations, posters and keynote addresses by leading researchers. 15-20 October 2018 DATE TIME EVENT VENUE

How to make a research

poster 12:30-13:30 Anita Dening Joske Room East MONDAY 15 OCTOBER Research Participant 14:00-16:00 Solaris Garden Afternoon Tea

Grand Round “How to implement patient reported outcomes in the real world: measuring what TUESDAY 12:15-13:30 really matters to patients 16 OCTOBER Joske Rooms and the healthcare system.” Professor Christobel Saunders AO and Dr Angela Ives History of Research at 12:30-13:30 SCGH Joske Room West Professor Peter Thompson

WEDNESDAY New Investigators 13:30-onwards Joske Room West 17 OCTOBER Presentations

17:00-19:30 (17:30 start) Quiz Night Charlies Social Club

Engaging Staff in Research 09:00-12:00 Presentations Joske Rooms

THURSDAY 12:00-12:30 Lunch Time Presentation Joske Rooms 18 OCTOBER

Engaging Staff in Research 12:30-15:00 Joske Rooms Presentations

ProudlyAVPU 2074-18 supported and funded by the Charlies Foundation for Research AVPU 2223-17

School of Human Sciences

The Head of School, Professor Shane Maloney, invites you to attend the

2018 SECOND SEMESTER, SHS SEMINAR SERIES

Title: To mend a broken heart, thou shalt learn from the ladies

Presenter: LAM Yun Wah, Associate Professor Department of Chemistry, City University of Hong Kong

When: Tuesday 16 October, 2018 @ 1pm

Venue: Room 1.81, Anatomy, Physiology & Human Biology Building North, The University of Western Australia (off Hackett Entrance No. 2)

Dr. Yun Wah Lam received his PhD training in the lab of Dr. Davina Opstelten at the University of Hong Kong. After receiving his PhD in 1996, he joined the group of Prof. Angus Lamond in Dundee, Scotland, where he developed an interest in the relationship of the architecture of mammalian cell nucleus and the regulation of gene expression. In 2007, he joined the Department of Biology and Chemistry, City University of Hong Kong. His team uses quantitative mass spectrometry to tackle a variety of biological projects, ranging from environmental sciences to regenerative medicine.

Biography

Zebrafish is one of the most well-established animal models for heart regeneration. Here, we report the sexual dimorphism of zebrafish heart regeneration, with females regenerating their hearts faster than males. Estradiol treatment of males accelerated cardiac regeneration, while tamoxifen treatment of females reduced it. This sexual dimorphism was abolished by oxygen, suggesting the involvement of the Hypoxia-inducible factor 1a (HIF1a) pathway. Remarkably, cardiac damages induced plasma estrogen levels and the expression of estrogen receptor genes in zebrafish, leading to the feminisation of males, as evidenced by the detection of female-specific plasma proteins, including vitellogenins, in males during heart regeneration. Oxygen stimulated estrogen receptor expression in regenerating hearts in males, suggesting an interplay between the estrogen- and HIF1a-related mechanisms in heart regeneration. We show that vitellogenins were expressed in the liver and accumulated in damaged male hearts; but not in other wounds or in regenerating fins. Taken together, our data indicate that in zebrafish females are more efficient in mending broken hearts, and males are spontaneously feminised during heart regeneration. This unexpected phenomenon elucidates a previously unknown aspect of zebrafish tissue regeneration.

RPH MEDICAL RESEARCH FORUM Seminar Series 2018

4th Floor Seminar Room Medical Research Foundation Building Rear 50 Murray St, Perth WA 6000 Wednesday @ 4pm Enquiries: W/Prof Markus Schlaich phone: 9224 0382 email: [email protected]

TIME: TUESDAY, 16 OCTOBER 2018 @ 4pm

VENUE: 5th Floor Seminar Room, MRF Building, Rear 50 Murray Street

PRESENTER: Dr Gretchen Gierach

TITLE: Breast Density and Hormones: Implications for Breast Cancer Etiology and Progression

Dr Gretchen Gierach earned her M.P.H. (2004) and Ph.D. (2006) in epidemiology from the University of Pittsburgh Graduate School of Public Health with concentrations in cancer epidemiology and women’s health. She joined the U.S. National Cancer Institute’s Division of Cancer Epidemiology and Genetics (DCEG) as an NCI Cancer Prevention Fellow in 2006, became a tenure-track investigator in 2010, and was awarded scientific tenure in 2017. Dr Gierach leads an integrative epidemiologic research program aimed at advancing our understanding of breast cancer etiology and progression through focused investigations of two of the strongest risk factors for sporadic breast cancer among women, namely mammographic breast density and hormones. Dr Gierach has been awarded the DCEG Molecular Epidemiology Research Funding Award, the NCI Merit Award in Cancer Prevention Research Training, and an Award to Advance Research on Cancers in Women from the NCI Office of Science Planning and Assessment and the NIH Office of Research on Women’s Health. Dr Gierach serves as chair of the Division’s Breast Cancer Working Group and co-chair of the DCEG Hormone Laboratory Advisory Committee.

LIGHT REFRESHMENTS WILL BE SERVED IMMEDIATELY FOLLOWING THE PRESENTATION PPEERRTTHH CCAANNCCEERR CCLLUUBB ((PPCCCC))

You are invited to our first meeting in 2018

to be held on Wednesday

17th October 2018 at 4:00pm

in the Harry Perkins Institute North, Room G24 (accessible from foyer)

Topic:

“Cancer Research at the QEII Medical Precinct”

Presenters:

Ruth Ganss Scientific Head Cancer Division Harry Perkins Institute

Katie Meehan Head Cancer Biology Division School of Biomedical Sciences, UWA

Terry Johns Program Head, Cancer Centre Telethon Kids Institute

Please note: this is a joint Perkins/TKI event Light refreshments will be provided.

Please send this invitation to other researchers who may be interested. For more information, please contact Ruth Ganss ([email protected])

THURSDAY 18 OCTOBER

Professor Jacques Miller

Emeritus Professor Walter and Eliza Hall Institute of Medical Research

"How the thymus has shaped Immunology and beyond"

Jacques Miller, AC, FRS is an Emeritus Professor at the Walter and Eliza Hall Institute of Medical Research in Melbourne. His long-spanning and highly acclaimed career in immunology has been focused primarily on the thymus. He discovered its function as the source of cellular immunity and also is credited with discovery of the dual nature of adaptive immunity (i.e. T and B lymphocytes), which identified the cellular building blocks of the immune system as we understand it today. He has won many awards including the Copley Medal of the Royal Society in London and most recently the 2018 Japan Prize for Medicine.

12:00noon till 1:00pm Followed by a light lunch For more information, please contact Grant Morahan E: [email protected]

MCCUSKER AUDITORIUM, HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH, NORTH CAMPUS

Program

Day 1 Thursday, 18 October 2018

Registration

Welcome to Country

Opening address

Setting the scene

Plenary: The need

Plenary: Evolution of precision public health

Sania Nishtar (Co-chair of the US National Academies of Sciences, Engineering, and Medicine Committee on Improving Global Quality of Healthcare; Co-chair of the Word Economic Forum’s Global Council on the Future of Health and Healthcare)

Morning tea

Enabling technologies – the engine of change

Plenary: What are enabling technologies?

Concurrent sessions:

 Genomics and other omics

 Personalised technologies

 Big data and real-time analytics

 Spatial technologies and climate change

 Data linkage  Analytics and artificial intelligence

 Translating new knowledge

Session reflection

David Ford (Principal Investigator and Director, Administrative Data Research Centre Wales)

Carolyn McGregor (Research Excellence Chair in Health Informatics, University of Ontario Institute of

Technology)

Este Geraghty (Chief Medical Officer and Health Solutions Director, Esri)

Yutao Du (Chief Technology Officer, BGI)

Jeremy Nicholson (Chair in Biological Chemistry, Imperial College London)

Lunch

Impacts and outcomes – learnings from our region

Plenary: Precision public health in action – Carmencita Padilla (Chancellor of University of the

Philippines)

Case studies:

 Diagnosis

 Surveillance and emergency response

 Treatment interventions

 Health service access and delivery

Panel: The impact of precision public health – past, present and future

Amanda Williamson (Senior Manager in Healthcare Assurance, PricewaterhouseCoopers) Wei Wang (Chief Medical Officer, BGI)

Gareth Baynam (Clinical Geneticist, Genetic Services of Western Australia; Program Director of the

Undiagnosed Diseases Program WA)

Makoto Suematsu (President, Japan Agency of Medical Research and Development)

Terry Slevin (Chief Executive Officer, Public Health Association Australia)

Afternoon tea

Envisioning precision public health

Facilitated workshop:

 Envisioning the future of precision public health in Asia

 Developing strategies to achieve the vision

Session reflection

Closing remarks

Symposium dinner

Day 2 Friday, 19 October 2018

Registration

Welcome to Day 2

Challenges – facing them head on

Talk to the experts about:

 Ethical and social challenges

 Community empowerment

 Privacy considerations and data access

 From research to practice

 Measuring impacts

Mengchun Gong (Executive Director, National Rare Diseases Registry System of China)

Getnet Tadele (Professor in Sociology, Addis Adaba University of Ethiopia)

Karen Carey (Chair of the NHMRC Community and Consumer Advisory Group, Australia)

Louis Niessen (Chair on Health Economics, Liverpool School of Tropical Medicine)

Morning tea

Opportunities – paving the way After having heard from influencers around the world on recent developments and the impact of precision public health on health outcomes, delegates are presented with an opportunity to pitch their own ideas in groups. In this session, we will learn from a diverse range of sectors, identify the areas of greatest need, share tips to adopting change and build international partnerships to create momentum.

Breakout sessions:

 Adopting change

 Aligning with regional objectives

 Learning from other sectors

 International partnerships

Lunch

Advancing precision public health

Having laid the foundations to progress precision public health in the Asia region, this session will have a large focus on participation from delegates to contribute to the development of a critical implementation plan and commit to action as stewards for precision public health

Facilitated workshop:

 Developing a critical implementation plan

 Building commitment, creating momentum

Afternoon tea

Wrapping it up This session will provide a recap of the symposium and summarise key steps moving forward. Delegates will be guided through this reflection and walk out equipped with the knowledge and partnerships to advance precision public health in their region.

Take home messages

Next steps

Closing address

Farewell ceremony

Early Intervention: Evidence based decision making for public services

Tom McBride Director of Evidence at the Early Intervention Foundation The Early Intervention Foundation (EIF) Director of Evidence, Tom McBride, will give an overview of the EIF’s vision, strategy and work, including their Cost of Late Intervention work and their current project in collaboration with CoLab to explore how applicable this approach would be in the Australian context. Tom will also give some thoughts on the UK’s What Works initiative and experiences of trying to embed evidence and research into the design and delivery of children’s policy at a national and local level.

Friday 19 October, 2018 7:30am – 9:30am Seminar Room (Level 5 West Wing), Telethon Kids Institute Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands All welcome – light breakfast included RSVP essential: https://colab-early-intervention-event.eventbrite.com.au

Telethon Kids Research Seminars

Elder/Co-researchers and the project team

The Ngulluk Koolunga Ngulluk Koort (Our Children, Our Heart) project

In this Seminar the Elder/Co-researchers and the project team will discuss the project’s participatory action research methodology along with the findings of the research to date.

19 October 2018

12noon – 1.00pm

Institute Seminar Room; Level 5 Perth Children’s Hospital

A light lunch will be provided at 11:45 for those attending the seminar Research Skills Seminar Series 2018 Research Education Program Involving Aboriginal People in Research Friday, 19 October 12:30 – 1:30PM

Are you currently conducting or planning a research project that could involve Aboriginal people? This seminar provides an overview of important considerations for engaging Aboriginal people in research, including; • Understanding cultural differences, • Ethical considerations, and • The importance of community consultation

Dr Michael Wright Dr Wright is a Yuat Nyoongar man whose family is from the Moora and New Norcia region of Western Australia, north of Perth. He is currently an Early Career Research Fellow with Curtin University and is based at the School of Occupational Therapy, Social Work, and Speech Pathology. Dr Wright has worked across the spectrum of health as manager, social work practitioner, and policy officer. He has extensive experience as a researcher in Aboriginal health and mental health. with Glenn Pearson Head of Aboriginal Research, Telethon Kids Institute and leads the Kulunga Aboriginal Research Development Unit (KARDU).

Perth Children’s Hospital *Hosted VC Sites Include: PCH Auditorium, Level 5 Bunbury Hospital (Pink or Yellow lifts) Child and Adolescent Community Health 15 Hospital Ave, Nedlands Curtin University Fiona Stanley Hospital Register Online Joondalup Health Campus Lions Eye Institute ResearchEducationProgram Midland Community Health Centre .eventbrite.com Royal Perth Hospital For more locations, visit: Further information: ResearchEducationProgram.org [email protected] ResearchEducationProgram.org *Online VC via Scopia App

The Research Skills Seminar Series is part of the Research Education Program, Department of Child Health Research, Perth Children’s Hospital, WA Department of Health. Seminars are hosted by WA Department of Health.

School of Human Sciences

The Head of School, Professor Shane Maloney, invites you to attend the

2018 SECOND SEMESTER, SPECIAL SEMINAR

Title: Busting myths about how mammals cope with heat – insights from free-living mammals

Presenter: Andrea Fuller, School of Physiology, University of the Witwatersrand, South Africa

When: Monday 22 October, 2018 @ 1pm

Venue: Seminar Room 1.81, Anatomy, Physiology & Human Biology Building North The University of Western Australia (off Hackett Entrance No. 2)

Speaker: Andrea Fuller is a Professor in the School of Physiology and Director of the Brain Function Research Group at the University of the Witwatersrand, South Africa. Her primary research focus is in the areas of thermal and conservation physiology, with an emphasis on understanding the physiological plasticity available to mammals to cope with climate change, and methods to improve the physiological welfare of mammals during game management practices. She has published more than 100 peer-reviewed articles, hosted seven postdoctoral fellows, and supervised 10 Doctoral and 13 Masters students to completion. She has served as chair of the Thermal Physiology Commission of the International Union of Physiological Sciences, and is an editorial board member of the journals Conservation Physiology; Temperature; and Koedoe - African Protected Area Conservation and Science.

Abstract: Fundamental to predicting the ecological consequences of climate change is understanding the physiological mechanisms available to mammals to cope with changing environments. Much of what we know about how mammals respond to heat is based on studies of mammals in the laboratory setting. Although this approach identifies what an animal can achieve physiologically, it does not reveal what an animal actually will do in its natural environment, where it is subjected to a complex array of stressors. Indeed, data obtained from free-living mammals reveal that we need to monitor the responses of mammals in their natural habitats if we wish to understand how they will prioritise competing homeostatic systems in changing environments, and the consequences of that prioritisation for their fitness.

Functional High Throughput Technologies AUSTRALIA FHTTA Meeting 2018 Gold Sponsors REGISTRATION NOW OPEN! John Curtin School of Medical Research Australian National University, Canberra

October 24-25th 2018 International and national experts will be presenting in these key areas: Silver Sponsor - High throughput screening - High content imaging and analysis Bronze Sponsors - RNAi screens Information and Registration: - Compound screening - CRISPR screening www.fhtta.com - New screening technologies FHTT_Australia Supported by:

Frank and Bobbie Fenner Trust

THURSDAY 25 OCTOBER

Professor Christobel Saunders AO

Professor of Surgical Oncology University of Western Australia

"Making your Cancer Research discoveries into better cancer treatments"

Professor Christobel Saunders AO MB BS, FRCS, FRACS, FAAHMS is internationally recognised as one of Australia’s most prominent research-orientated cancer surgeons. She has substantially contributed to many clinical aspects of breast cancer research including clinical trials of new treatments, psychosocial, translational and health services research and is active in several areas of surgical oncology cancer research, with a particular emphasis on breast cancer. She has performed research for >25 years and in the past five years, has published over 100 peer-reviewed journal articles (including two in The Lancet).

12:00noon till 1:00pm Followed by a light lunch For more information, please contact Louise Winteringham E: [email protected]

MCCUSKER AUDITORIUM, HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH, NORTH CAMPUS

Research Skills Seminar Series 2018 Research Education Program Statistical Tips for Interpreting Scientific Claims Friday, 26 October 12:30 – 1:30PM

This seminar complements the earlier "Critical Appraisal of Scientific Literature" seminar and uses examples from medical literature to further unpick statistics presented in peer reviewed research papers. It will “help non‐scientists interrogate advisers and grasp the limitations of evidence” and provide guidance on when it is time to consult the statisticians.

These tips are highly relevant for those looking for a refresher in statistical literacy or struggling to understand the seemingly unlimited sources of bias and confounding.

Doctor Julie Marsh Julie is an experienced statistical consultant who has worked in the Pharmaceutical industry for many years before returning to academia. She teaches statistics at UWA and is a Senior Research Fellow at the Telethon Kids Institute.

Perth Children’s Hospital *Hosted VC Sites Include: PCH Auditorium, Level 5 Bunbury Hospital (Pink or Yellow lifts) 15 Hospital Ave, Nedlands Child and Adolescent Community Health Fiona Stanley Hospital Joondalup Health Campus Register Online Lions Eye Institute Midland Community Health Centre ResearchEducationProgram Royal Perth Hospital .eventbrite.com For more locations, visit: Further information: ResearchEducationProgram.org [email protected] ResearchEducationProgram.org *Online VC via Scopia App

Confirmed Speakers Sunghee Cho, PhD Burke Neurological Institute, Andrew Wesseldine, MD NY, USA Western Australian Department of Health, WA, AUS Timothy Murphy, PhD University of British Columbia, Bruno Meloni, PhD, BAPPSCI (HONS) VBC, CAN Perron Institute for Neurological and Translational Science, WA, AUS Session Chairs Cathy Stinear, PhD Janet Taylor, MD University of Auckland, AC, NZ Edith Cowan University, WA Neuroscience Research Australia, David Blacker, MBBS, FRACP Hosted By Perron Institute for Neurological NSW, AUS and Translational Science, WA, AUS Lay Kho, MBBS, FRACP NeuroRehabilitation and Robotics Laboratory Erin Godecke, PhD Royal Perth and Edith Cowan University, WA, AUS St John of God Midland School of Medical and Public and Private Hospitals, WA, AUS Health Sciences, ECU Hermano Krebs, PhD Massachusetts Institute of Tim Bates, FRACP Technology, MA, USA St John of God Midland Venue Public and Private Hospitals, WA, AUS Julie Bernhardt, PhD Edith Cowan University Florey Institute of Neuroscience 270 Joondalup Drive, and Mental Health, VIC, AUS Joondalup WA 6027 Perth Australia Laurel Buxbaum, PsyD Lyn Beazley, AO FTSE Moss Rehabilitation Research (Opening Speaker) Spaces Limited! Institute, PA, USA Murdoch University, WA, AUS Register Here Nick Ward, MD Rajiv R. Ratan, MD, PhD University College London, LDN, UK Contact: Dr Manonita Ghosh (Keynote Speaker) [email protected] Stephen Scott, PhD Burke Neurological Institute, NY, USA Queen’s University, ON, CAN Website: ecu.edu.au/ Dylan Edwards, PhD (Chair) conferences/post-stroke-2018 Steve Cramer, MD, PhD Edith Cowan University, WA, AUS University of California, CA, USA Burke Neurological Institute, NY, USA ASMI2018

Australian Society of Molecular Imaging Perth 2018 Scientific Meeting

20-21 November 2018

This is the fourth in the series of annual scientific symposia hosted by the Australian Society of Molecular Imaging. It brings together researchers from a wide range of disciplines interested in the development and applications of multi-modality molecular imaging. Other topics covered include novel molecular imaging probes and applications of molecular imaging in neuroscience, cardiology, metabolic disorders and cancer, to name a few.