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Case Study Report BRAIN INITIATIVE Mission-oriented R&I policies: In-depth case studies Case Study Report BRAIN INITIATIVE (US) Eva Arrilucea, Hanna Kuittinen February 2018 Case Study Report: Brain Initiative (United States) European Commission Directorate-General for Research and Innovation Directorate A — Policy Development and Coordination Unit A.6 — Open Data Policy and Science Cloud Contact Arnold Weiszenbacher E-mail [email protected] [email protected] European Commission B-1049 Brussels Manuscript completed in February 2018. This document has been prepared for the European Commission however it reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein. More information on the European Union is available on the internet (http://europa.eu). Luxembourg: Publications Office of the European Union, 2017 PDF ISBN 978-92-79-80162-4 doi:10.2777/1986 KI-01-18-153-EN-N © European Union, 2018. Reuse is authorised provided the source is acknowledged. The reuse policy of European Commission documents is regulated by Decision 2011/833/EU (OJ L 330, 14.12.2011, p. 39). For any use or reproduction of photos or other material that is not under the EU copyright, permission must be sought directly from the copyright holders. Brain Initiative 2 EUROPEAN COMMISSION Mission-oriented R&I policies: In-depth case studies Case Study Report Brain Initiative (United States) Eva Arrilucea Hanna Kuittinen A Study coordinated by the Joint Institute for Innovation Policy February 2018 Directorate-General for Research and Innovation Table of Contents 1 Summary of the case study ................................................................................... 1 2 Context and objectives of the initiative ................................................................... 4 2.1 Contextual factors and origins of initiative ....................................................... 4 2.2 Strategic and operative objectives and milestones of the initiative ..................... 7 3 Resources and management .................................................................................. 9 3.1 Governance and management model .............................................................. 9 3.2 Financing model ......................................................................................... 10 3.3 Key actors and key technologies and platforms involved in the initiative ........... 13 3.4 Monitoring system and evaluation of the initiatives ........................................ 16 3.5 Level and type of citizen engagement in the initiative ..................................... 16 4 Policy instruments and wider policy-mix used for implementing the initiative ............. 17 4.1 Description of the R&I policy instruments used for implementing of the initiative ............................................................................................................... 17 4.2 Connection with other policies ..................................................................... 21 4.3 Key turning points of the initiative and policy adaptation measures .................. 24 5 Realised or expected outputs, outcomes and impacts ............................................. 26 5.1 Outputs and New Instruments ..................................................................... 26 5.2 Outcomes ................................................................................................. 26 5.3 Impacts .................................................................................................... 26 5.4 Summary of the key indicators. ................................................................... 27 6 Conclusions and lessons learned .......................................................................... 29 6.1 Identification and assessment of key strengths and weaknesses of the initiative 29 6.2 Lessons learned and key messages for European R&I policy ............................ 29 References ................................................................................................................. 31 1 Summary of the case study This document analyses the case study of mission-oriented R&I policy initiatives in the field of BRAIN studies and more concretely, the US BRAIN Initiative. The following table describes the main components of the case study: BRAIN INITIATIVE Title: The Brain Initiative Country: USA Thematic area: Health Objective(s): The Brain Initiative seeks to deepen understanding of the inner workings of the human mind and to improve how we treat, prevent, and cure disorders of the brain. Main Governing Body Private-Public Partnership Timeline: 2013-2025 Budget: USD 1.36 billion (public and private funding from 2013 to 2016) and USD 1.5 billion (part of public funding estimated from 2017 to 2025). Brief description of the On April 2, 2013, President Obama launched the BRAIN Initiative as case (250 words) part of a broader White House Neuroscience Initiative to “accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought.” The challenge is to map the circuits of the brain, measure the fluctuating patterns of electrical and chemical activity flowing within those circuits, and understand how their interplay creates our unique cognitive and behavioural capabilities Implementation and The BRAIN Initiative is a public-private partnership including organisation (a brief National Institutes of Health NIH, National Science Foundation NSF, description of the Defense Advanced Research Projects Agency DARPA, Intelligence governance and policy Advanced Research Projects Activity IARPA, Food and Drug instruments used) Administration FDA and several private foundations, institutes, universities, companies and international partners. Observed / expected • Since the beginning of BRAIN Initiative, there are almost 300 outputs, outcomes, and publications classified in seven research categories: cell types, circuit impacts diagrams, monitor neural activity, interventional tools, theory and data analysis tools, human neuroscience and integrated approaches. • New tools and technologies. In general, technologies that are emerging from BRAIN Initiative are diverse and range from transgenic animals to sophisticated instrumentation to computational tools. Some examples are: DREADD (Designer Receptor Exclusively Activated by a Designer Drug) technology, to experimentally control circuits in animal’s brains in order to understand their function; optogenetics, a technique that allows researchers to control neuronal activity with light; miniature fluorescence microscopes, a new technology to record from thousands of neurons simultaneously; a neuroprosthetic device that translates “thoughts” into movement; diagrams ranging in scale; Brainbow, to colour neurons with fluorescent dye; CLARITY, a tissue- preservation method; photoacoustic imaging, a technique that blends the speed of precision of light with the penetrating ability of sound to interrogate neural activity; Z-brain, an open-source anatomical atlas of the entire zebrafish brain; miniaturised and highly sensitive electrophysiology and optical imaging instruments; improvements in functional magnetic resonance imaging (fMRI) • New platforms. The International Brain Station, a virtual platform for collaboration and data sharing for neuroscientists worldwide, Neurodata Without Borders, another platform to share physiological data, NeuroNex, a National Research Infrastructure for Neuroscience. • 306 publications Brain Initiative 1 BRAIN INITIATIVE • BRAIN Initiative has inspired similar large-scale brain research projects around the world, including Japan, Australia, Canada, China, South Korea and Israel. Main elements of mission-oriented R&I initiative: 1 Directionality: YES. Neurological disorders are one of the main causes of death over the world and entails a substantial and increased cost in the US. Intentionality: YES. The initiative has specific and well-articulated targets: • Accelerate the development and application of new neurotechnologies; • Enable researchers to produce a dynamic picture of the brain functioning in real time; • Explore how the brain records, processes, uses, stores, and retrieves vast quantities of information; • Shed light on the complex links between brain function and behaviour, incorporating new theories and computational models; • Help bring safe and effective products to patients and consumers. Clearly set timeline and YES. The initiative has defined scientific milestones with clear milestones: horizons: • Discovering diversity; • Maps at multiple scales; • The brain in action; • Demonstrating causality; • Identifying fundamental principles; • Advancing human neuroscience; • From BRAIN Initiative to the brain. Mobilises public and YES. The BRAIN Initiative is a public-private partnership including private investments: National Institutes of Health NIH, National Science Foundation NSF, Defense Advanced Research Projects Agency DARPA, Intelligence Advanced Research Projects Activity IARPA, Food and Drug Administration FDA and several private foundations, institutes, universities, companies and international partners. Focused on new YES. the BRAIN Initiative has a primary focus on technology knowledge creation development in the first five years (2016-2020), (basic research, TRLs 1- 4): Focused on knowledge YES.
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