(KRT6B) Rabbit Polyclonal Antibody – TA322591

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TA322591

Cytokeratin 6B (KRT6B) Rabbit Polyclonal Antibody Product data:

Product Type: Primary Antibodies Applications: IHC Recommended Dilution: ELISA: 1:2000-5000, IHC: 1:50-200 Reactivity: Human, Mouse, Rat Host: Rabbit Isotype: IgG Clonality: Polyclonal Immunogen: Synthetic peptide corresponding to a region derived from 73-87 amino acids of human keratin 6B Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol Concentration: lot specific Purification: Antigen affinity purification Conjugation: Unconjugated Storage: Store at -20°C as received. Stability: Stable for 12 months from date of receipt. Gene Name: keratin 6B Database Link: NP_005546 Entrez Gene 16688 MouseEntrez Gene 3854 Human P04259 Background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue; the stratified epithelial lining of oral mucosa and esophagus; the outer root sheath of hair follicles; and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 Cytokeratin 6B (KRT6B) Rabbit Polyclonal Antibody – TA322591

Synonyms: CK-6B; CK6B; K6B; KRTL1; PC2; PC4

Product images:

Predicted cell location: Cytoplasm. Positive control: Human ovarian and breast cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin- embedded human ovarian cancer tissue using KRT6B antibody at dilution 1/, on the right is treated with the synthetic peptide. (Original magnification:x 200)

Predicted cell location: Cytoplasm. Positive control: Human ovarian and breast cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin- embedded human breast cancer tissue using KRT6B antibody at dilution 1/, on the right is treated with the synthetic peptide. (Original magnification:x200)