Supplementary Materials and Methods Pulmonary fibrosis model in rat A total of 60 SPF male Wistar rats (6-week-old) weighing 190–210 g and have never mated were used in the study. All animals were obtained from Shanghai Super-B&K Animal Laboratory Co., Ltd. (Shanghai, China), with Certification No. SCXK 2013-0016. All animals were housed under specific pathogen-free conditions in accordance with the provision and general recommendation of the Chinese Experimental Animals Administration Legislation. The 6-week-old SPF male Wistar rats were randomly divided into 9 treatment groups with 3 rats. According to the improved method[1,2], modeling method for a dministering BLM in a single dose after one week of adaptive feeding. In the experiments, equal volume of saline was administered as a control group. Rats from the PF model group underwent intranasal instillation of a single dose of 3.5 μg/g and 7 μg/g BLM in saline (100 μl, 150 μl and 200 μl). All groups were sacrificed at the 28th day. The lung tissue of rats were embedded in sections, then treated with H&E staining. Quantitative RT-PCR analysis For RNA isolation, tumors were homogenized and suspended, and RNA was extracted using the RNAspin Mini Kit (GE Healthcare, Waukesha, WI, USA) according to the manufacturer's instructions. For cDNA synthesis, 1μg of total RNA was reverse-transcribed using oligo-dT primers and the Superscript Amplification System (Life Technologies, Carlsbad, CA, USA). Quantitative RT-PCR was carried out using SYBR Green PCR Master Mix (Life Technologies). The PCR amplification program consisted of an initial polymerase activation at 94°C for 5 min, followed by 35 cycles at 94°C for 30 s, 59.5°C for 40 s and 72°C for 30 s. Amplification of GAPDGH, a relatively invariant internal reference RNA, was performed in parallel, and cDNA amounts were standardized to equivalent GAPDGH mRNA levels.

Supplementary Fig. 1 Scheme and process of BLM-induced Pulmonary fibrosis animal experiment.

Supplementary Fig. 2 Effect of different doses of BLM-induced alteration in lung histology of rats. Photomicrograph of sections of lungs of normal (BLM 0 mg/kg); low-dose BLM ( BLM 3.5 mg/kg) groups and high-dose BLM (BLM 7.0 mg/kg) groups. Rats treated with nasal BLM instillation of three dose at 100μL, 150μL, and 200μL. Photographs were taken with a high-resolution microscope, scale bar, 50μm. The data presented were obtained from three independent experiments.

Supplementary Fig. 3 Effect of of XJXBCQ on Smad7 expression in MRC-5 cells. (A and B) Western blot assay was conducted to detect the levels of Smad7 in MRC-5 cells. MRC-5 cells were treated with TGF-β1 for 48 h firstly, Then cells were treated with different reagents as previous methods. Western blot with an antibody to GAPDH was used to ensure equal loading of proteins in each lane. Bolts were photographed and quantified for each sample. The data presented were obtained from three independent experiments. Each value is presented as the mean ± SD of three independent experiments.

Supplementary Fig. 4 The effect of XJXBCQ on smad2 and smad7 mRNA levels in MRC-5 cells.

Real-time quantitative PCR was performed to detect smad2 and smad7 mRNA in vitro. The data represented here were calculated from the means ± SD from triplicate experiments.

Supplementary Fig. 5 Effect of of XJXBCQ and up-smad2 on MRC-5 cells proliferation. Cells were treated with various concentrations of XJXBCQ and analyzed by CCK-8 analyses as previously. Reference

1. Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA . Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem Biol Interact. 2015;237:151-165.

2. Hu J, Liu XL. Establishment and Pathological Evolution of Pulmonary Fibrosis Model in Mice Induced by bleomycin nasal instillation. Chinese Journal of Experimental Animals. 2009;17(5):352-354. Supplementary Table 1

1 2 aloe-emodin Prostaglandin G/H synthase 1 aloe-emodin Prostaglandin G/H synthase 2 aloe-emodin Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate aloe-emodin 3-kinase catalytic subunit, gamma isoform aloe-emodin mRNA of PKA Catalytic Subunit C-alpha aloe-emodin Nuclear receptor coactivator 2 cAMP-dependent protein kinase inhibitor aloe-emodin alpha aloe-emodin Aldose reductase aloe-emodin Ig gamma-1 chain C region aloe-emodin Cyclin-dependent kinase inhibitor 1 aloe-emodin Eukaryotic translation initiation factor 6 aloe-emodin Apoptosis regulator BAX aloe-emodin Tumor necrosis factor aloe-emodin Caspase-3 aloe-emodin Cellular tumor antigen p53 aloe-emodin Fatty acid synthase aloe-emodin Protein kinase C alpha type aloe-emodin Protein kinase C epsilon type aloe-emodin Cell division control protein 2 homolog aloe-emodin Proliferating cell nuclear antigen aloe-emodin Myc proto-oncogene protein aloe-emodin Interleukin-1 beta aloe-emodin Protein kinase C delta type aloe-emodin G2/mitotic-specific cyclin-B1 aloe-emodin Smad aloe-emodin Transforming growth factor beta-1 EUPATIN Nitric oxide synthase, inducible EUPATIN Androgen receptor EUPATIN Coagulation factor Xa EUPATIN Prostaglandin G/H synthase 2 EUPATIN Coagulation factor VII EUPATIN DNA topoisomerase II EUPATIN Estrogen receptor beta EUPATIN Dipeptidyl peptidase IV EUPATIN Heat shock protein HSP 90 EUPATIN Trypsin-1 EUPATIN Nuclear receptor coactivator 2 EUPATIN Calmodulin EUPATIN Thrombin Sodium channel protein type 5 subunit EUPATIN alpha Vascular endothelial growth factor EUPATIN receptor 2 Peroxisome proliferator activated receptor EUPATIN delta (-)-catechin Prostaglandin G/H synthase 1 (-)-catechin Estrogen receptor (-)-catechin Prostaglandin G/H synthase 2 (-)-catechin Heat shock protein HSP 90 (-)-catechin Beta-lactamase (-)-catechin mRNA of PKA Catalytic Subunit C-alpha (-)-catechin Nuclear receptor coactivator 2 (-)-catechin Calmodulin (-)-catechin Fatty acid synthase Peroxisome proliferator-activated receptor (-)-catechin gamma (-)-catechin Krueppel-like factor 7 (-)-catechin Smad (-)-catechin Transforming growth factor beta-1 (-)-catechin farnesoid X receptor (-)-catechin C-X-C motif chemokine ligand 1 (-)-catechin AotanB (-)-catechin Nuclear factor erythroid-2-related factor 2 (-)-catechin caspase-8 (-)-catechin caspase-3 (-)-catechin Filaggrin (-)-catechin Hyaluronan synthase 1 (-)-catechin Hyaluronan synthase 2 (-)-catechin Interleukin-6 (-)-catechin Tumor necrosis factor alpha (-)-catechin Nuclear factor-kappa B (-)-catechin Interleukin-1 beta (-)-catechin Apoptosis regulator BAX (-)-catechin Mitogen activated kinase-like protein (-)-catechin phosphatase 1 Enhancer of zeste 2 polycomb repressive (-)-catechin complex 2 subunit (-)-catechin Nuclear factor erythroid-2-related factor 1 (-)-catechin GA repeat binding protein, alpha (-)-catechin C-X-C motif chemokine ligand 10 (-)-catechin Matrix metallopeptidase 3 (-)-catechin Matrix metallopeptidase 13 (-)-catechin Nitric oxide synthase 2 (-)-catechin Fatty acid binding protein 5 (-)-catechin Apoptosis regulator Bcl-2 (-)-catechin Interleukin-1 (-)-catechin Interleukin-10 (-)-catechin Interleukin-17 (-)-catechin Interleukin-4 (-)-catechin Pancreatic and duodenal homeobox 1 (-)-catechin Solute carrier family 2 member 2 Peroxisome proliferative activated (-)-catechin receptor, gamma, coactivator 1 alpha (-)-catechin Cellular tumor antigen p53 (-)-catechin Catalase (-)-catechin Tumor necrosis factor-alpha (-)-catechin Interleukin-1 beta (-)-catechin COX-2 (-)-catechin Nitric oxide synthase, inducible (-)-catechin AKT serine/threonine kinase 1 (-)-catechin C-Jun N-terminal kinase (-)-catechin Superoxide dismutase 2 (-)-catechin N-myristoyltransferase 1 (-)-catechin N-myristoyltransferase 2 (-)-catechin Tuberous sclerosis 2 (-)-catechin Phytochelatin synthase 2 (-)-catechin Isochorismate synthase 2 (-)-catechin Mucin 2, oligomeric mucus/gel-forming (-)-catechin Mucin 3, intestinal Inhibitor of nuclear factor kappa B kinase (-)-catechin subunit alpha (-)-catechin Cyclin dependent kinase inhibitor 1A (-)-catechin Prominin 1 (-)-catechin ABCG2 (-)-catechin DNA methyltransferase 3 beta (-)-catechin Histone deacetylase 1 (-)-catechin Retinoic acid receptor beta (-)-catechin Cadherin 1 (-)-catechin Death associated protein kinase 1 Signal transducer and activator of (-)-catechin transcription 5 (-)-catechin Forkhead box O1 (-)-catechin Prostaglandin E receptor 3 (-)-catechin Matrix metallopeptidase 2 (-)-catechin Aldehyde dehydrogenase, cytosolic 1-like (-)-catechin Matrix metallopeptidase 9 Kirsten rat sarcoma viral oncogene (-)-catechin homolog (-)-catechin Surfactant protein B (-)-catechin Alpha-Smooth muscle actin (-)-catechin Heme oxygenase-1 (-)-catechin NAD(P)H quinone dehydrogenase 1 (-)-catechin GDP-D-glucose phosphorylase 1 (-)-catechin CD18 protein (-)-catechin Beta-catenin (-)-catechin ERK-family protein kinase, putative (-)-catechin Phospholipase A2 group IIA (-)-catechin Apolipoprotein A1 (-)-catechin Apolipoprotein A4 (-)-catechin Fatty acid binding protein 4 Phosphoinositide-3-kinase regulatory (-)-catechin subunit 5 (-)-catechin Diacylglycerol O-acyltransferase 2 (-)-catechin Prostaglandin-endoperoxide synthase 2 rhein Prostaglandin G/H synthase 1 rhein Prostaglandin G/H synthase 2 rhein Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate rhein 3-kinase catalytic subunit, gamma isoform rhein Nuclear receptor coactivator 2 rhein Aldose reductase rhein Transcription factor AP-1 rhein Transforming growth factor beta-1 rhein Hypoxia-inducible factor 1 rhein C-X-C motif chemokine ligand 1 rhein Interleukin-8 Toralactone Nitric oxide synthase, inducible Toralactone Prostaglandin G/H synthase 1 Toralactone Estrogen receptor Toralactone Prostaglandin G/H synthase 2 Toralactone Estrogen receptor beta Toralactone Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate Toralactone 3-kinase catalytic subunit, gamma isoform Toralactone Serine/threonine-protein kinase Chk1 Toralactone mRNA of PKA Catalytic Subunit C-alpha Peroxisome proliferator activated receptor Toralactone gamma Toralactone Paraoxonase 1 Toralactone Phosphatidylinositol-3-kinase Toralactone Glycogen synthase kinase 3 beta Toralactone Glycolate oxidase Toralactone Caspase-3 Toralactone Apoptosis regulator BAX Toralactone Apoptosis regulator Bcl-2 Toralactone Prostaglandin E receptor 3 Emodin-1-O-beta-D-glucopyranoside DNA topoisomerase II Torachrysone-8-O-beta-D-(6'-oxayl)-gluco DNA topoisomerase II side Physciondiglucoside DNA topoisomerase II Daucosterol_qt Progesterone receptor Daucosterol_qt Nuclear receptor coactivator 2 beta-sitosterol Progesterone receptor beta-sitosterol Nuclear receptor coactivator 2 beta-sitosterol Prostaglandin G/H synthase 1 beta-sitosterol Prostaglandin G/H synthase 2 beta-sitosterol Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate beta-sitosterol 3-kinase catalytic subunit, gamma isoform Potassium voltage-gated channel beta-sitosterol subfamily H member 2 beta-sitosterol mRNA of PKA Catalytic Subunit C-alpha beta-sitosterol Dopamine D1 receptor beta-sitosterol Muscarinic acetylcholine receptor M3 beta-sitosterol Muscarinic acetylcholine receptor M1 Sodium channel protein type 5 subunit beta-sitosterol alpha Gamma-aminobutyric-acid receptor beta-sitosterol alpha-2 subunit beta-sitosterol Muscarinic acetylcholine receptor M4 CGMP-inhibited 3',5'-cyclic beta-sitosterol phosphodiesterase A beta-sitosterol 5-hydroxytryptamine 2A receptor Gamma-aminobutyric-acid receptor beta-sitosterol alpha-5 subunit beta-sitosterol Alpha-1A adrenergic receptor Gamma-aminobutyric-acid receptor beta-sitosterol alpha-3 subunit beta-sitosterol Muscarinic acetylcholine receptor M2 beta-sitosterol Alpha-1B adrenergic receptor beta-sitosterol Beta-2 adrenergic receptor Neuronal acetylcholine receptor subunit beta-sitosterol alpha-2 beta-sitosterol Sodium-dependent serotonin transporter beta-sitosterol Mu-type opioid receptor Gamma-aminobutyric acid receptor beta-sitosterol subunit alpha-1 Neuronal acetylcholine receptor protein, beta-sitosterol alpha-7 chain beta-sitosterol Cytochrome P450-cam beta-sitosterol Apoptosis regulator Bcl-2 beta-sitosterol Apoptosis regulator BAX beta-sitosterol Caspase-9 beta-sitosterol Transcription factor AP-1 beta-sitosterol Caspase-3 beta-sitosterol Caspase-8 beta-sitosterol Protein kinase C alpha type beta-sitosterol Transforming growth factor beta-1 beta-sitosterol Serum paraoxonase/arylesterase 1 beta-sitosterol Microtubule-associated protein 2 beta-sitosterol Smad Glycyrol Nitric oxide synthase, inducible Glycyrol Estrogen receptor Peroxisome proliferator activated receptor Glycyrol gamma Glycyrol Prostaglandin G/H synthase 2 Vascular endothelial growth factor Glycyrol receptor 2 Glycyrol Mitogen-activated protein kinase 14 Glycyrol Glycogen synthase kinase-3 beta Glycyrol Serine/threonine-protein kinase Chk1 Proto-oncogene serine/threonine-protein Glycyrol kinase Pim-1 Glycyrol Cyclin-A2 Glycyrol Thrombin Glycyrol Nuclear factor-kappa B Glycyrol Nuclear factor of activated T-cells Glycyrol I-kappaB l-SPD Prostaglandin G/H synthase 1 l-SPD Dopamine D1 receptor l-SPD Muscarinic acetylcholine receptor M3 Potassium voltage-gated channel l-SPD subfamily H member 2 l-SPD Muscarinic acetylcholine receptor M1 l-SPD D(1B) dopamine receptor Sodium channel protein type 5 subunit l-SPD alpha l-SPD Coagulation factor Xa l-SPD Muscarinic acetylcholine receptor M5 l-SPD Prostaglandin G/H synthase 2 l-SPD Carbonic anhydrase II l-SPD Alpha-2C adrenergic receptor l-SPD Muscarinic acetylcholine receptor M4 l-SPD Retinoic acid receptor RXR-alpha l-SPD Delta-type opioid receptor l-SPD 5-hydroxytryptamine 2A receptor l-SPD Alpha-1A adrenergic receptor l-SPD 5-hydroxytryptamine 2C receptor l-SPD Muscarinic acetylcholine receptor M2 l-SPD Alpha-2B adrenergic receptor l-SPD Alpha-1B adrenergic receptor l-SPD D(3) dopamine receptor l-SPD Sodium-dependent dopamine transporter l-SPD Beta-2 adrenergic receptor l-SPD Alpha-1D adrenergic receptor l-SPD Sodium-dependent serotonin transporter l-SPD Mu-type opioid receptor l-SPD Heat shock protein HSP 90 l-SPD mRNA of PKA Catalytic Subunit C-alpha l-SPD Calmodulin Machiline Prostaglandin G/H synthase 1 Machiline Muscarinic acetylcholine receptor M3 Machiline Muscarinic acetylcholine receptor M1 Machiline Beta-1 adrenergic receptor Sodium channel protein type 5 subunit Machiline alpha Machiline Prostaglandin G/H synthase 2 Machiline Alpha-2A adrenergic receptor Machiline Alpha-2C adrenergic receptor Machiline Muscarinic acetylcholine receptor M4 Machiline Retinoic acid receptor RXR-alpha CGMP-inhibited 3',5'-cyclic Machiline phosphodiesterase A Machiline Alpha-1A adrenergic receptor Machiline Alpha-2B adrenergic receptor Machiline Alpha-1B adrenergic receptor Machiline Sodium-dependent dopamine transporter Machiline Beta-2 adrenergic receptor Machiline Alpha-1D adrenergic receptor Machiline Sodium-dependent serotonin transporter Machiline Heat shock protein HSP 90 Machiline Nuclear receptor coactivator 2 Machiline Calmodulin Phaseol Thrombin Phaseol Estrogen receptor Phaseol Androgen receptor Peroxisome proliferator activated receptor Phaseol gamma Phaseol Prostaglandin G/H synthase 2 Vascular endothelial growth factor Phaseol receptor 2 Phaseol Mitogen-activated protein kinase 14 Phaseol Glycogen synthase kinase-3 beta Phaseol Heat shock protein HSP 90 Phaseol Cell division protein kinase 2 Phaseol Serine/threonine-protein kinase Chk1 Phaseol mRNA of PKA Catalytic Subunit C-alpha Proto-oncogene serine/threonine-protein Phaseol kinase Pim-1 Phaseol Cyclin-A2 Licochalcone B Nitric oxide synthase, inducible Licochalcone B Prostaglandin G/H synthase 1 Licochalcone B Estrogen receptor Licochalcone B Androgen receptor Peroxisome proliferator activated receptor Licochalcone B gamma Licochalcone B Prostaglandin G/H synthase 2 Licochalcone B Carbonic anhydrase II CGMP-inhibited 3',5'-cyclic Licochalcone B phosphodiesterase A Licochalcone B Beta-2 adrenergic receptor Licochalcone B Estrogen receptor beta Licochalcone B Mitogen-activated protein kinase 14 Licochalcone B Glycogen synthase kinase-3 beta Licochalcone B Heat shock protein HSP 90 Licochalcone B Cell division protein kinase 2 Licochalcone B Serine/threonine-protein kinase Chk1 Licochalcone B mRNA of PKA Catalytic Subunit C-alpha Proto-oncogene serine/threonine-protein Licochalcone B kinase Pim-1 Licochalcone B Cyclin-A2 Licochalcone B Calmodulin liquiritin Coagulation factor Xa liquiritin Coagulation factor VII liquiritin Calmodulin liquiritin Prostaglandin G/H synthase 2 Vascular endothelial growth factor liquiritin receptor 2 liquiritin Superoxide dismutase [Cu-Zn] liquiritin Transforming growth factor beta-1 liquiritin Nuclear factor erythroid-2-related factor 2 liquiritin Matrix metallopeptidase 9 liquiritin Squalene synthase 1 liquiritin Dopamine receptor D2 liquiritin Interferon gamma ORMDL sphingolipid biosynthesis liquiritin regulator 3 liquiritin C-X-C motif chemokine ligand 1 UDP glucuronosyltransferase family 1 liquiritin member A1 liquiritin Glyoxylate carboligase liquiritin Multidrug resistance protein 2 liquiritin ABCB11 liquiritin Matrix metallopeptidase 2 liquiritin Nitric oxide synthase, inducible liquiritin COX-2 liquiritin Mitogen activated kinase-like protein liquiritin Interleukin-1 beta liquiritin Interleukin-6 Peroxisome proliferator activated receptor liquiritin gamma liquiritin Connexin 43 liquiritin Cytochrome P450-cam liquiritin Nerve growth factor liquiritin gamma-aminobutyric acid B Mairin Progesterone receptor (+)-catechin Prostaglandin G/H synthase 1 (+)-catechin Estrogen receptor (+)-catechin Prostaglandin G/H synthase 2 (+)-catechin Heat shock protein HSP 90 (+)-catechin Beta-lactamase (+)-catechin mRNA of PKA Catalytic Subunit C-alpha (+)-catechin Nuclear receptor coactivator 2 (+)-catechin Calmodulin (+)-catechin Retinoic acid receptor RXR-alpha (+)-catechin Catalase (+)-catechin Hyaluronan synthase 2 (+)-catechin Smad (+)-catechin Transforming growth factor beta-1 (+)-catechin YTH domain family 2 (+)-catechin Cyclin-A2 (+)-catechin Cyclin-dependent kinase 2 Sterol regulatory element binding (+)-catechin transcription factor 1 3-hydroxy-3-methylglutaryl-coenzyme A (+)-catechin reductase 1 (+)-catechin Immune deficiency (+)-catechin Rhodopsin (+)-catechin Rab7 (+)-catechin Cellular tumor antigen p53 (+)-catechin Tumor necrosis factor alpha (+)-catechin Mitogen activated kinase-like protein (+)-catechin Nitric oxide synthase estrone Dopamine D1 receptor estrone Muscarinic acetylcholine receptor M3 estrone Thrombin estrone Muscarinic acetylcholine receptor M1 estrone Muscarinic acetylcholine receptor M5 estrone Prostaglandin G/H synthase 2 estrone Carbonic anhydrase II estrone Muscarinic acetylcholine receptor M4 estrone Retinoic acid receptor RXR-alpha estrone Delta-type opioid receptor estrone Acetylcholinesterase CGMP-inhibited 3',5'-cyclic estrone phosphodiesterase A estrone 5-hydroxytryptamine 2A receptor Sodium-dependent noradrenaline estrone transporter estrone Alpha-1A adrenergic receptor estrone 5-hydroxytryptamine 2C receptor estrone Progesterone receptor estrone Muscarinic acetylcholine receptor M2 estrone Kappa-type opioid receptor estrone Sodium-dependent dopamine transporter estrone Beta-2 adrenergic receptor estrone Alpha-1D adrenergic receptor estrone Sodium-dependent serotonin transporter estrone D(2) dopamine receptor estrone Mu-type opioid receptor estrone Smad estrone Transforming growth factor beta-1 estrone Hydroxysteroid 17-beta dehydrogenase 1 Glabridin Nitric oxide synthase, inducible Glabridin Muscarinic acetylcholine receptor M1 Glabridin Estrogen receptor Glabridin Androgen receptor Sodium channel protein type 5 subunit Glabridin alpha Peroxisome proliferator activated receptor Glabridin gamma Glabridin Prostaglandin G/H synthase 2 Glabridin Retinoic acid receptor RXR-alpha Glabridin Acetylcholinesterase Glabridin Alpha-1B adrenergic receptor Glabridin Beta-2 adrenergic receptor Glabridin Estrogen receptor beta Glabridin Mitogen-activated protein kinase 14 Glabridin Glycogen synthase kinase-3 beta Glabridin Cell division protein kinase 2 Glabridin Serine/threonine-protein kinase Chk1 Glabridin mRNA of PKA Catalytic Subunit C-alpha Glabridin Retinoic acid receptor RXR-beta Glabridin Ig gamma-1 chain C region Glabridin Trypsin-1 Proto-oncogene serine/threonine-protein Glabridin kinase Pim-1 Glabridin Cyclin-A2 Glabridin Nuclear receptor coactivator 2 Glabridin Nuclear receptor coactivator 1 Glabridin Calmodulin Glabridin Smad Glabridin Transforming growth factor beta-1 Glabridin Organic cation/carnitine transporter 4 Peroxisome proliferator activated receptor Glabridin delta Glabridin Wnt family member 1 Glabridin Interleukin-6 Glabridin Tumor necrosis factor alpha Glabridin Estrogen receptor alpha Glabridin Apoptosis regulator Bcl-2 Glabridin Paraoxonase 2 Glabridin Type-1 fimbrial protein subunit A Glabridin Rhamnosyltransferase Glabridin Focal adhesion kinase ROS proto-oncogene 1, receptor tyrosine Glabridin kinase Glabridin E-cadherin Glabridin Bone morphogenetic protein 2 Glabridin Bone morphogenetic protein 4 Glabridin Bone morphogenetic protein 7 Glabridin Phosphatidylinositol-3-kinase Glabridin AKT serine/threonine kinase 2 Glabridin Glutathione peroxidase 4 Sterol regulatory element binding Glabridin transcription factor 1 Glabridin TNF superfamily member 11 Triiodothyronine receptor auxiliary Glabridin protein Glabridin TNF receptor associated factor 6 Growth factor receptor bound protein Glabridin 2-associated protein 2 Glabridin Mitogen-activated protein kinase 8 Glabridin MAP kinase kinase 7 SRC proto-oncogene, non-receptor Glabridin tyrosine kinase Glabridin Matrix metallopeptidase 9 Glabridin Carbonic anhydrase 2 T cell immune regulator 1, ATPase H+ Glabridin transporting V0 subunit a3 Osteopetrosis associated transmembrane Glabridin protein 1 Glabridin Chloride voltage-gated channel 7 Glabridin C-Jun N-terminal kinase Glabridin Mitogen-activated protein kinase 1 Glabridin Multidrug resistance protein 1 Stigmasterol Progesterone receptor Stigmasterol Mineralocorticoid receptor Stigmasterol Nuclear receptor coactivator 2 Stigmasterol Alcohol dehydrogenase 1C Stigmasterol Ig gamma-1 chain C region Stigmasterol Retinoic acid receptor RXR-alpha Stigmasterol Nuclear receptor coactivator 1 Stigmasterol Prostaglandin G/H synthase 1 Stigmasterol Prostaglandin G/H synthase 2 Stigmasterol Alpha-2A adrenergic receptor Sodium-dependent noradrenaline Stigmasterol transporter Stigmasterol Sodium-dependent dopamine transporter Stigmasterol Beta-2 adrenergic receptor Stigmasterol Aldose reductase Stigmasterol Urokinase-type plasminogen activator Stigmasterol Leukotriene A-4 hydrolase Stigmasterol Amine oxidase [flavin-containing] B Stigmasterol Amine oxidase [flavin-containing] A Stigmasterol mRNA of PKA Catalytic Subunit C-alpha Stigmasterol Chymotrypsinogen B Stigmasterol Muscarinic acetylcholine receptor M3 Stigmasterol Muscarinic acetylcholine receptor M1 Stigmasterol Beta-1 adrenergic receptor Sodium channel protein type 5 subunit Stigmasterol alpha Stigmasterol 5-hydroxytryptamine 2A receptor Stigmasterol Alpha-1A adrenergic receptor Gamma-aminobutyric-acid receptor Stigmasterol alpha-3 subunit Stigmasterol Muscarinic acetylcholine receptor M2 Stigmasterol Alpha-1B adrenergic receptor Gamma-aminobutyric acid receptor Stigmasterol subunit alpha-1 Neuronal acetylcholine receptor protein, Stigmasterol alpha-7 chain Stigmasterol Smad Stigmasterol ABCG5 Stigmasterol ABCG8 Stigmasterol COX-2 Stigmasterol Tumor necrosis factor alpha Stigmasterol Nitric oxide synthase, inducible Stigmasterol Mitogen-activated protein kinase 1 Stigmasterol Nuclear factor-kappa B Stigmasterol liver X receptor Stigmasterol Interleukin-6 Stigmasterol Tumor necrosis factor Stigmasterol Matrix metallopeptidase 9 Stigmasterol Intercellular adhesion molecule 1 Stigmasterol Apoptosis regulator BAX Stigmasterol Tumor necrosis factor alpha Stigmasterol Nuclear factor erythroid-2-related factor 2 11,14-eicosadienoic acid Nuclear receptor coactivator 2 11,14-eicosadienoic acid Carnitine Palmitoyl Transferase 1 11,14-eicosadienoic acid Acetyl-coenzyme A carboxylase 1 11,14-eicosadienoic acid Fatty acid desaturase 2 CLR Progesterone receptor CLR Mineralocorticoid receptor CLR Cytochrome P450-cam CLR Nuclear receptor coactivator 2 CLR Transforming growth factor beta-1 sitosterol Progesterone receptor sitosterol Nuclear receptor coactivator 2 sitosterol Mineralocorticoid receptor sitosterol Smad sitosterol Transforming growth factor beta-1 sitosterol Sterol regulatory element binding factor 2 Proprotein convertase subtilisin/kexin type sitosterol 9 sitosterol DEGs sitosterol ABCG5 sitosterol Methyl-CpG binding protein 2 Small glutamine-rich tetratricopeptide sitosterol containing protein sitosterol Interleukin-8 sitosterol C-X-C motif chemokine ligand 1 Microtubule-associated protein 1 light sitosterol chain 3 beta sitosterol Beclin1 Microtubule-associated protein 1 light sitosterol chain 3 alpha sitosterol Hypothetical protein sitosterol Myc proto-oncogene protein sitosterol Interferon gamma sitosterol Vascular endothelial growth factor sitosterol Nuclear factor erythroid-2-related factor 2 Peroxisome proliferator activated receptor sitosterol gamma sitosterol Proliferating cell nuclear antigen sitosterol Sterol methyltransferase 2 sitosterol Alpha-Smooth muscle actin Sterol regulatory element binding sitosterol transcription factor 1 sitosterol Insulin like growth factor 1 Flagellar class II regulon transcriptional sitosterol activator sitosterol ABCA1 sitosterol ABCG1 sitosterol AMP-activated protein kinase sitosterol C-Jun N-terminal kinase NPC1 like intracellular cholesterol sitosterol transporter 1 sitosterol Glycogen synthase kinase 3 beta sitosterol Peroxisome proliferator activated receptor sitosterol liver X receptor sitosterol Farnesoid X-activated receptor sitosterol ABCA1 gondoic acid Prostaglandin G/H synthase 1 gondoic acid Nuclear receptor coactivator 2 Spinasterol Progesterone receptor Spinasterol Mineralocorticoid receptor Spinasterol Nuclear receptor coactivator 2 Spinasterol ABCA1 Spinasterol ABCG1 Spinasterol C-C motif chemokine ligand 17 Spinasterol Nuclear factor-kappa B Signal transducer and activator of Spinasterol transcription 1 Spinasterol Tumor necrosis factor alpha Spinasterol Interleukin-6 Spinasterol Interleukin-1 beta Inhibitor of nuclear factor kappa B kinase Spinasterol subunit alpha Gibberellin A44 Mineralocorticoid receptor Gamma-aminobutyric acid receptor Gibberellin A44 subunit alpha-1 Gamma-aminobutyric-acid receptor Gibberellin A44 subunit alpha-6 Gamma-aminobutyric-acid receptor GA60 alpha-2 subunit Gamma-aminobutyric-acid receptor GA60 alpha-3 subunit GA60 Muscarinic acetylcholine receptor M2 Gamma-aminobutyric acid receptor GA60 subunit alpha-1 GA60 Glutamate receptor 2 4a-formyl-7alpha-hydroxy-1-methyl-8-me thylidene-4aalpha,4bbeta-gibbane-1alpha, Mineralocorticoid receptor 10beta-dicarboxylic acid 4a-formyl-7alpha-hydroxy-1-methyl-8-me thylidene-4aalpha,4bbeta-gibbane-1alpha, Progesterone receptor 10beta-dicarboxylic acid GA122-isolactone Progesterone receptor 2,3-didehydro GA77 Prostaglandin G/H synthase 2 2,3-didehydro GA77 Carbonic anhydrase II Gamma-aminobutyric acid receptor 2,3-didehydro GA77 subunit alpha-1 2,3-didehydro GA77 Nuclear receptor coactivator 2 Gamma-aminobutyric-acid receptor 2,3-didehydro GA77 subunit alpha-6 Gamma-aminobutyric-acid receptor GA77 alpha-2 subunit Gamma-aminobutyric acid receptor GA77 subunit alpha-1 GA77 Cytochrome P450-cam GA77 Glutamate receptor 2 GA120 Muscarinic acetylcholine receptor M3 GA120 Muscarinic acetylcholine receptor M1 GA120 Prostaglandin G/H synthase 2 Gamma-aminobutyric-acid receptor GA120 alpha-3 subunit GA120 Muscarinic acetylcholine receptor M2 Gamma-aminobutyric acid receptor GA120 subunit alpha-1 Neuronal acetylcholine receptor protein, GA120 alpha-7 chain Gamma-aminobutyric-acid receptor GA120 subunit alpha-6 GA119 Cytochrome P450-cam gibberellin 7 Muscarinic acetylcholine receptor M3 gibberellin 7 Muscarinic acetylcholine receptor M1 gibberellin 7 Prostaglandin G/H synthase 2 CGMP-inhibited 3',5'-cyclic gibberellin 7 phosphodiesterase A gibberellin 7 Sodium-dependent dopamine transporter gibberellin 7 Beta-2 adrenergic receptor gibberellin 7 Sodium-dependent serotonin transporter GA121-isolactone Progesterone receptor GA87 Prostaglandin G/H synthase 2 GA87 Carbonic anhydrase II GA63 Prostaglandin G/H synthase 2 Gamma-aminobutyric acid receptor GA63 subunit alpha-1 Neuronal acetylcholine receptor protein, GA63 alpha-7 chain GA63 Glutamate receptor 2 GA63 Gamma-aminobutyric-acid receptor subunit alpha-6 GA54 Coagulation factor Xa GA54 Prostaglandin G/H synthase 2 mRNA of Protein-tyrosine phosphatase, GA54 non-receptor type 1 GA54 Heat shock protein HSP 90 GA54 Nuclear receptor coactivator 2 GA54 Calmodulin 2,3-didehydro GA70 Prostaglandin G/H synthase 1 2,3-didehydro GA70 Muscarinic acetylcholine receptor M1 2,3-didehydro GA70 Prostaglandin G/H synthase 2 Sodium-dependent noradrenaline 2,3-didehydro GA70 transporter Gamma-aminobutyric acid receptor 2,3-didehydro GA70 subunit alpha-1 2,3-didehydro GA70 Trypsin-1 2,3-didehydro GA70 Glutamate receptor 2 Sitosterol alpha1 Progesterone receptor Sitosterol alpha1 Prostaglandin G/H synthase 2 Gamma-aminobutyric acid receptor Sitosterol alpha1 subunit alpha-1 Sitosterol alpha1 Alcohol dehydrogenase 1C Sitosterol alpha1 Cytochrome P450-cam Sitosterol alpha1 Mineralocorticoid receptor 3-O-p-coumaroylquinic acid Prostaglandin G/H synthase 1 3-O-p-coumaroylquinic acid Prostaglandin G/H synthase 2 mRNA of Protein-tyrosine phosphatase, 3-O-p-coumaroylquinic acid non-receptor type 1 3-O-p-coumaroylquinic acid Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate 3-O-p-coumaroylquinic acid 3-kinase catalytic subunit, gamma isoform 3-O-p-coumaroylquinic acid mRNA of PKA Catalytic Subunit C-alpha 3-O-p-coumaroylquinic acid Nuclear receptor coactivator 2 3-O-p-coumaroylquinic acid Calmodulin campesterol Progesterone receptor campesterol Prostaglandin G/H synthase 1 campesterol Prostaglandin G/H synthase 2 campesterol Heat shock protein HSP 90 Phosphatidylinositol-4,5-bisphosphate campesterol 3-kinase catalytic subunit, gamma isoform campesterol Nuclear receptor coactivator 2 campesterol Interleukin-8 campesterol Nuclear factor erythroid-2-related factor 2 campesterol Sterol regulatory element binding transcription factor 1 hederagenin Progesterone receptor hederagenin Nuclear receptor coactivator 2 hederagenin Muscarinic acetylcholine receptor M3 hederagenin Muscarinic acetylcholine receptor M1 Gamma-aminobutyric-acid receptor hederagenin alpha-2 subunit Gamma-aminobutyric-acid receptor hederagenin alpha-3 subunit hederagenin Muscarinic acetylcholine receptor M2 hederagenin Alpha-1B adrenergic receptor Gamma-aminobutyric acid receptor hederagenin subunit alpha-1 hederagenin Glutamate receptor 2 Gamma-aminobutyric-acid receptor hederagenin subunit alpha-6 Gamma-aminobutyric-acid receptor hederagenin alpha-5 subunit hederagenin Ig gamma-1 chain C region hederagenin Alcohol dehydrogenase 1B hederagenin Alcohol dehydrogenase 1C hederagenin Lysozyme Nicotinate-nucleotide--dimethylbenzimida hederagenin zole phosphoribosyltransferase hederagenin Prostaglandin G/H synthase 1 Sodium channel protein type 5 subunit hederagenin alpha hederagenin Prostaglandin G/H synthase 2 hederagenin Retinoic acid receptor RXR-alpha CGMP-inhibited 3',5'-cyclic hederagenin phosphodiesterase A Sodium-dependent noradrenaline hederagenin transporter hederagenin Cytochrome P450-cam hederagenin Tumor necrosis factor alpha hederagenin 5-hydroxytryptamine 1A receptor hederagenin Apoptosis regulator BAX hederagenin Apoptosis regulator Bcl-2 hederagenin Apoptosis regulator Bcl-xL hederagenin Survivin hederagenin Caspase-9 hederagenin Caspase-3 hederagenin Poly-(ADP-ribose) polymerase hederagenin Beta-amyrin synthase-like hederagenin Nuclear factor-kappa B hederagenin COX-2 hederagenin Nitric oxide synthase, inducible hederagenin Mitogen-activated protein kinase 1 hederagenin C-Jun N-terminal kinase hederagenin AKT serine/threonine kinase 1 hederagenin Formyl peptide receptor 1 hederagenin Phenol oxidase Linolenic acid ethyl ester Prostaglandin G/H synthase 1 Linolenic acid ethyl ester Prostaglandin G/H synthase 2 Linolenic acid ethyl ester Mitogen-activated protein kinase 1 Linolenic acid ethyl ester C-Jun N-terminal kinase Linolenic acid ethyl ester Cyclin-dependent kinase 10α-cucurbita-5,24-diene-3β-ol Progesterone receptor 10α-cucurbita-5,24-diene-3β-ol Mineralocorticoid receptor Mandenol Prostaglandin G/H synthase 1 Mandenol Prostaglandin G/H synthase 2 Mandenol Nuclear receptor coactivator 2 Schottenol Progesterone receptor Schottenol Nuclear receptor coactivator 2 Schottenol liver X receptor-α Schottenol liver X receptor-β Schottenol ABCA1 Schottenol ABCG1 7-oxo-dihydrokaro-unidiol Mineralocorticoid receptor Hydroxygenkwanin Nitric oxide synthase, inducible Hydroxygenkwanin Prostaglandin G/H synthase 1 Hydroxygenkwanin Prostaglandin G/H synthase 2 Hydroxygenkwanin Dipeptidyl peptidase IV Hydroxygenkwanin Heat shock protein HSP 90 Hydroxygenkwanin mRNA of PKA Catalytic Subunit C-alpha Hydroxygenkwanin Trypsin-1 Hydroxygenkwanin Nuclear receptor coactivator 2 Hydroxygenkwanin Calmodulin Phosphatidylinositol-4,5-bisphosphate Hydroxygenkwanin 3-kinase catalytic subunit, gamma isoform vitamin-e Coagulation factor Xa vitamin-e Smad vitamin-e Transforming growth factor beta-1 vitamin-e DNA repair gene MutL homolog 1 vitamin-e DNA methyltransferase 1 vitamin-e Protein Kinase Cα vitamin-e Nuclear factor-kappa B vitamin-e Interleukin-1 vitamin-e Tumor necrosis factor alpha Peroxisome proliferator activated receptor vitamin-e gamma vitamin-e AKT serine/threonine kinase 1 vitamin-e Phosphatase and tensin homolog Cytochrome P450 family 4 subfamily F vitamin-e member 2 Sterol regulatory element binding vitamin-e transcription factor 1 vitamin-e ABCA1 vitamin-e liver X receptor-α vitamin-e CD36 molecule vitamin-e phosphatidylinositol-3-kinase gamma vitamin-e Protein kinase B vitamin-e Vascular endothelial growth factor Vascular endothelial growth factor vitamin-e receptor 2 vitamin-e Caspase-9 vitamin-e Caspase-3 vitamin-e Apoptosis regulator BAX vitamin-e phosphatase 1 vitamin-e phosphatase 2 vitamin-e Mitogen-activated protein kinase 1 Kirsten rat sarcoma viral oncogene vitamin-e homolog vitamin-e Harvey rat sarcoma virus oncogene vitamin-e Phosphatidylinositol-3-kinase vitamin-e Cyclin D1 Diosmetin Nitric oxide synthase, inducible Diosmetin Prostaglandin G/H synthase 1 Diosmetin Prostaglandin G/H synthase 2 Diosmetin Dipeptidyl peptidase IV Diosmetin Heat shock protein HSP 90 Diosmetin mRNA of PKA Catalytic Subunit C-alpha Diosmetin Trypsin-1 Diosmetin Nuclear receptor coactivator 2 Diosmetin Nuclear receptor coactivator 1 Diosmetin Calmodulin Diosmetin Transforming growth factor beta-1 Diosmetin Centrosomal protein 350 Diosmetin Nuclear factor erythroid-2-related factor 2 Diosmetin NLR family pyrin domain containing 3 Diosmetin Heme oxygenase-1 Diosmetin Tumor necrosis factor alpha Diosmetin Interleukin-1 beta Diosmetin Interleukin-6 Diosmetin Cellular tumor antigen p53

Diosmetin Matrix metallopeptidase 2 Diosmetin Matrix metallopeptidase 9 Diosmetin Nuclear factor-kappa B Diosmetin Solute carrier family 2 member 4 Cytochrome P450 family 1 subfamily A Diosmetin member 1 5-dehydrokarounidiol Glucocorticoid receptor

Supplementary Table 2

target t aloe-emodin 1 EUPATIN 1 (-)-catechin 1 rhein 1 Toralactone 1 Emodin-1-O-beta-D-glucopyranoside 1 Torachrysone-8-O-beta-D-(6'-oxayl)-glucoside 1 Physciondiglucoside 1 Daucosterol_qt 1 beta-sitosterol 5 Glycyrol 2 l-SPD 2 Machiline 2 Phaseol 2 Licochalcone B 2 liquiritin 2 Mairin 2 (+)-catechin 2 estrone 2 Glabridin 2 Stigmasterol 2 11,14-eicosadienoic acid 2 CLR 2 sitosterol 2 gondoic acid 2 Spinasterol 6 Gibberellin A44 3 GA60 3 4a-formyl-7alpha-hydroxy-1-methyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10bet 3 a-dicarboxylic acid GA122-isolactone 3 2,3-didehydro GA77 3 GA77 3 GA120 3 GA119 3 gibberellin 7 3 GA121-isolactone 3 GA87 3 GA63 3 GA54 3 2,3-didehydro GA70 3 Sitosterol alpha1 3 3-O-p-coumaroylquinic acid 3 campesterol 3 hederagenin 3 Linolenic acid ethyl ester 4 10α-cucurbita-5,24-diene-3β-ol 4 Mandenol 4 Schottenol 4 7-oxo-dihydrokaro-unidiol 4 Hydroxygenkwanin 4 vitamin-e 4 Diosmetin 4 5-dehydrokarounidiol 4 Prostaglandin G/H synthase 1 7 Prostaglandin G/H synthase 2 7 Heat shock protein HSP 90 7 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform 7 mRNA of PKA Catalytic Subunit C-alpha 7 Nuclear receptor coactivator 2 7 cAMP-dependent protein kinase inhibitor alpha 7 Aldose reductase 7 Ig gamma-1 chain C region 7 Cyclin-dependent kinase inhibitor 1 7 Eukaryotic translation initiation factor 6 7 Apoptosis regulator BAX 7 Tumor necrosis factor 7 Caspase-3 7 Cellular tumor antigen p53 7 Fatty acid synthase 7 Protein kinase C alpha type 7 Protein kinase C epsilon type 7 Cell division control protein 2 homolog 7 Proliferating cell nuclear antigen 7 Myc proto-oncogene protein 7 Interleukin-1 beta 7 Protein kinase C delta type 7 G2/mitotic-specific cyclin-B1 7 Smad 8 Transforming growth factor beta-1 12 Nitric oxide synthase, inducible 7 Androgen receptor 7 Coagulation factor Xa 7 Coagulation factor VII 7 DNA topoisomerase II 7 Estrogen receptor beta 7 Dipeptidyl peptidase IV 7 Trypsin-1 7 Calmodulin 7 Thrombin 7 Sodium channel protein type 5 subunit alpha 7 Vascular endothelial growth factor receptor 2 7 Peroxisome proliferator activated receptor delta 7 Estrogen receptor 7 Beta-lactamase 7 Peroxisome proliferator-activated receptor gamma 7 Krueppel-like factor 7 7 farnesoid X receptor 7 C-X-C motif chemokine ligand 1 7 AotanB 7 Nuclear factor erythroid-2-related factor 2 7 caspase-8 7 Filaggrin 7 Hyaluronan synthase 1 7 Hyaluronan synthase 2 7 Interleukin-6 7 Tumor necrosis factor alpha 7 Nuclear factor-kappa B 7 Mitogen activated kinase-like protein 7 phosphatase 1 7 Enhancer of zeste 2 polycomb repressive complex 2 subunit 7 Nuclear factor erythroid-2-related factor 1 7 GA repeat binding protein, alpha 7 C-X-C motif chemokine ligand 10 7 Matrix metallopeptidase 3 7 Matrix metallopeptidase 13 7 Nitric oxide synthase 2 7 Fatty acid binding protein 5 7 Apoptosis regulator Bcl-2 7 Interleukin-1 7 Interleukin-10 7 Interleukin-17 7 Interleukin-4 7 Pancreatic and duodenal homeobox 1 7 Solute carrier family 2 member 2 7 Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 7 Catalase 7 Tumor necrosis factor-alpha 7 COX-2 7 AKT serine/threonine kinase 1 7 C-Jun N-terminal kinase 7 Superoxide dismutase 2 7 N-myristoyltransferase 1 7 N-myristoyltransferase 2 7 Tuberous sclerosis 2 7 Phytochelatin synthase 2 7 Isochorismate synthase 2 7 Mucin 2, oligomeric mucus/gel-forming 7 Mucin 3, intestinal 7 Inhibitor of nuclear factor kappa B kinase subunit alpha 7 Cyclin dependent kinase inhibitor 1A 7 Prominin 1 7 ABCG2 7 DNA methyltransferase 3 beta 7 Histone deacetylase 1 7 Retinoic acid receptor beta 7 Cadherin 1 7 Death associated protein kinase 1 7 Signal transducer and activator of transcription 5 7 Forkhead box O1 7 Prostaglandin E receptor 3 7 Matrix metallopeptidase 2 7 Aldehyde dehydrogenase, cytosolic 1-like 7 Matrix metallopeptidase 9 7 Kirsten rat sarcoma viral oncogene homolog 7 Surfactant protein B 7 Alpha-Smooth muscle actin 7 Heme oxygenase-1 7 NAD(P)H quinone dehydrogenase 1 7 GDP-D-glucose phosphorylase 1 7 CD18 protein 7 Beta-catenin 7 ERK-family protein kinase, putative 7 Phospholipase A2 group IIA 7 Apolipoprotein A1 7 Apolipoprotein A4 7 Fatty acid binding protein 4 7 Phosphoinositide-3-kinase regulatory subunit 5 7 Diacylglycerol O-acyltransferase 2 7 Prostaglandin-endoperoxide synthase 2 7 Transcription factor AP-1 7 Hypoxia-inducible factor 1 7 Interleukin-8 7 Serine/threonine-protein kinase Chk1 7 Peroxisome proliferator activated receptor gamma 7 Paraoxonase 1 7 Phosphatidylinositol-3-kinase 7 Glycogen synthase kinase 3 beta 7 Glycolate oxidase 7 Progesterone receptor 7 Potassium voltage-gated channel subfamily H member 2 7 Dopamine D1 receptor 7 Muscarinic acetylcholine receptor M3 7 Muscarinic acetylcholine receptor M1 7 Gamma-aminobutyric-acid receptor alpha-2 subunit 7 Muscarinic acetylcholine receptor M4 7 CGMP-inhibited 3',5'-cyclic phosphodiesterase A 7 5-hydroxytryptamine 2A receptor 7 Gamma-aminobutyric-acid receptor alpha-5 subunit 7 Alpha-1A adrenergic receptor 7 Gamma-aminobutyric-acid receptor alpha-3 subunit 7 Muscarinic acetylcholine receptor M2 7 Alpha-1B adrenergic receptor 7 Beta-2 adrenergic receptor 7 Neuronal acetylcholine receptor subunit alpha-2 7 Sodium-dependent serotonin transporter 7 Mu-type opioid receptor 7 Gamma-aminobutyric acid receptor subunit alpha-1 7 Neuronal acetylcholine receptor protein, alpha-7 chain 7 Cytochrome P450-cam 7 Caspase-9 7 Serum paraoxonase/arylesterase 1 7 Microtubule-associated protein 2 7 Mitogen-activated protein kinase 14 7 Glycogen synthase kinase-3 beta 7 Proto-oncogene serine/threonine-protein kinase Pim-1 7 Cyclin-A2 7 Nuclear factor of activated T-cells 7 I-kappaB 7 D(1B) dopamine receptor 7 Muscarinic acetylcholine receptor M5 7 Carbonic anhydrase II 7 Alpha-2C adrenergic receptor 7 Retinoic acid receptor RXR-alpha 7 Delta-type opioid receptor 7 5-hydroxytryptamine 2C receptor 7 Alpha-2B adrenergic receptor 7 D(3) dopamine receptor 7 Sodium-dependent dopamine transporter 7 Alpha-1D adrenergic receptor 7 Beta-1 adrenergic receptor 7 Alpha-2A adrenergic receptor 7 Cell division protein kinase 2 7 Calmodulin 7 Superoxide dismutase [Cu-Zn] 7 Squalene synthase 1 7 Dopamine receptor D2 7 Interferon gamma 7 ORMDL sphingolipid biosynthesis regulator 3 7 UDP glucuronosyltransferase family 1 member A1 7 Glyoxylate carboligase 7 Multidrug resistance protein 2 7 ABCB11 7 Mitogen activated kinase-like protein 7 Connexin 43 7 Nerve growth factor 7 gamma-aminobutyric acid B 7 YTH domain family 2 7 Cyclin-dependent kinase 2 7 Sterol regulatory element binding transcription factor 1 7 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 7 Immune deficiency 7 Rhodopsin 7 Rab7 7 Nitric oxide synthase 7 Acetylcholinesterase 7 Sodium-dependent noradrenaline transporter 7 Kappa-type opioid receptor 7 D(2) dopamine receptor 7 Hydroxysteroid 17-beta dehydrogenase 1 7 Retinoic acid receptor RXR-beta 7 Nuclear receptor coactivator 1 7 Organic cation/carnitine transporter 4 7 Wnt family member 1 7 Estrogen receptor alpha 7 Paraoxonase 2 7 Type-1 fimbrial protein subunit A 7 Rhamnosyltransferase 7 Focal adhesion kinase 7 ROS proto-oncogene 1, receptor tyrosine kinase 7 E-cadherin 7 Bone morphogenetic protein 2 7 Bone morphogenetic protein 4 7 Bone morphogenetic protein 7 7 AKT serine/threonine kinase 2 7 Glutathione peroxidase 4 7 TNF superfamily member 11 7 Triiodothyronine receptor auxiliary protein 7 TNF receptor associated factor 6 7 Growth factor receptor bound protein 2-associated protein 2 7 Mitogen-activated protein kinase 8 7 MAP kinase kinase 7 7 SRC proto-oncogene, non-receptor tyrosine kinase 7 Carbonic anhydrase 2 7 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 7 Osteopetrosis associated transmembrane protein 1 7 Chloride voltage-gated channel 7 7 Mitogen-activated protein kinase 1 7 Multidrug resistance protein 1 7 Mineralocorticoid receptor 7 Alcohol dehydrogenase 1C 7 Urokinase-type plasminogen activator 7 Leukotriene A-4 hydrolase 7 Amine oxidase [flavin-containing] B 7 Amine oxidase [flavin-containing] A 7 Chymotrypsinogen B 7 ABCG5 7 ABCG8 7 liver X receptor 7 Intercellular adhesion molecule 1 7 Carnitine Palmitoyl Transferase 1 7 Acetyl-coenzyme A carboxylase 1 7 Fatty acid desaturase 2 7 Sterol regulatory element binding factor 2 7 Proprotein convertase subtilisin/kexin type 9 7 DEGs 7 Methyl-CpG binding protein 2 7 Small glutamine-rich tetratricopeptide containing protein 7 Microtubule-associated protein 1 light chain 3 beta 7 Beclin1 7 Microtubule-associated protein 1 light chain 3 alpha 7 Hypothetical protein 7 Vascular endothelial growth factor 7 Sterol methyltransferase 2 7 Insulin like growth factor 1 7 Flagellar class II regulon transcriptional activator 7 ABCA1 7 ABCG1 7 AMP-activated protein kinase 7 NPC1 like intracellular cholesterol transporter 1 7 Peroxisome proliferator activated receptor 7 Farnesoid X-activated receptor 7 ABCA1 7 C-C motif chemokine ligand 17 7 Signal transducer and activator of transcription 1 7 Gamma-aminobutyric-acid receptor subunit alpha-6 7 Glutamate receptor 2 7 mRNA of Protein-tyrosine phosphatase, non-receptor type 1 7 Alcohol dehydrogenase 1B 7 Lysozyme 7 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 7 5-hydroxytryptamine 1A receptor 7 Apoptosis regulator Bcl-xL 7 Survivin 7 Poly-(ADP-ribose) polymerase 7 Beta-amyrin synthase-like 7 Formyl peptide receptor 1 7 Phenol oxidase 7 Cyclin-dependent kinase 7 liver X receptor-α 7 liver X receptor-β 7 DNA repair gene MutL homolog 1 7 DNA methyltransferase 1 7 Protein Kinase Cα 7 Phosphatase and tensin homolog 7 Cytochrome P450 family 4 subfamily F member 2 7 CD36 molecule 7 phosphatidylinositol-3-kinase gamma 7 Protein kinase B 7 phosphatase 2 7 Harvey rat sarcoma virus oncogene 7 Cyclin D1 7 Centrosomal protein 350 7 NLR family pyrin domain containing 3 7 Heme oxygenase-1 7 Solute carrier family 2 member 4 7 Cytochrome P450 family 1 subfamily A member 1 7 Glucocorticoid receptor 7