FY 2019 Research Annual Report
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UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE RESEARCH ANNUAL REPORT 2019 The UNIVERSITY OF CINCINNATI is classified as anR1: Doctoral University – Very high research activity institution. The COLLEGE OF MEDICINE OFFICE OF RESEARCH has made a commitment to: • Creating impactful and sustainable biomedical research programs. • Developing passionate and innovative research teams. • Becoming a destination for clinical trials. • Harnessing “big data” to be not just evidence-based, but also evidence-gathering. Three institutes—operated jointly with UC Health and focused on cancer, neurosciences and cardiovascular disease—with a center for metabolic health serve as the foundation for these commitments. FROM THE OFFICE OF THE DEAN Andrew T. Filak Jr., MD Melanie T. Cushion, PhD Brett M. Kissela, MD, MS Senior Vice President for Senior Associate Dean Senior Associate Dean Health Affairs and Dean for Research for Clinical Research THROUGHOUT fiscal year (FY) 2019 the investments in the renewal of our research University of Cincinnati College of Medicine commitment, and the deployment of new celebrated 200 years of rich achievements knowledge, therapies, and devices that in research, education, and clinical practice. improve the lives of patients locally and This bicentennial year gave our college an globally. opportunity to reflect on our history. As the FY 2019 was an extraordinary year first medical school in Ohio established by for research at the College of Medicine. Daniel Drake, MD, we have been fortunate Our researchers brought in more awards that our college faculty and graduates (233 total awards) and total award grant have consistently risen to the challenge dollars (with the exception of FY 2016) than of innovating, discovering and improving in years past. The total new grant dollars medicine through research. Our research rose from $95 million in FY 2018 to $143 mission has been a critical component million in FY 2019, contributing significantly of the college since those early days and to the research mission of the University. continues to provide groundbreaking discoveries in a myriad of diverse areas FY 2019 RESEARCH AND CLINICAL TRIAL of medicine from cancer to cardiology to AWARDS Percentage of Revenue by College stroke and infectious diseases. The FY 2019 Research Annual Report • Medicine of the UC College of Medicine tracks our 68% latest research progress, highlights our • Engineering and outstanding researchers, and recognizes Applied Science 10% the successes of our research faculty during Arts and Sciences this past year. The accomplishments of • 8% our faculty reflect our commitment to All Other Colleges the career success of our investigators, • 14% RESEARCH ANNUAL REPORT 2019 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE 3 In fact, our college brought in 68% of the instrumentation and qualified personnel total research dollars the university received to begin to build a core footprint in the last year. Additionally, our percentage critical area of Metabolomics. Finally, our of funded applications increased from Proteomics laboratory was awarded a 23% to 35% which by far exceeds the NIH high-end instrumentation grant from the average success rate (20%). As we applaud NIH ($815,798) at the end of the FY to our College of Medicine annualized grant continue to build on the success they have holdings of $105 million we embrace our had in supporting investigators with protein five year goal of increasing grant holdings characterization and comparative protein to $125 million. profiling studies. The system is expected to Our clinical faculty are sought for their be installed and validated in time to begin expertise in clinical trials. Not only are we supporting research projects in January working with top pharmaceutical sponsors 2020. to help bring new and novel drugs/devices Training and education of graduate to market, many of our clinical trialists are students represents a critical part of leading several large federally funded trial our research and discovery mission networks. This year over twenty clinical as we cultivate the next generation of trialists brought in a revenue of $100,000 research scientists who will provide or more. On average, our clinical trials the vital biomedical breakthroughs revenue has increased 10% each year since of the 21st century. Our master’s and FY 2013. In FY 2019, our clinical trialists certificate programs continue to grow brought in revenue of $14.5 million which in size and popularity, and additional is an impressive $2.4 million increase from opportunities for skill and knowledge last fiscal year. enhancement have been afforded with the Recognizing the vital role that core introduction of a new track in the Clinical facilities and shared equipment play & Translational Research MS program in the success of our researchers, we for clinical research professionals, as well initiated core enhancement opportunities as a brand-new Certificate in Telehealth. beginning in FY 2016. These funds allow Our PhD programs continue their record core directors to validate and offer new of notable successes in both scholarship innovative services to our faculty to keep and national recognition for individual them competitive. Additional investments students. For the third year running, in FY 2019 have included new image a College of Medicine doctoral student analysis systems to support microscopy was recognized with the Presidential core users and the integration of advanced Medal of Graduate Student Excellence, RESEARCH ANNUAL REPORT 2019 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE 4 while another was recognized for current in basic research and clinical sciences excellence and exceptional future promise under the respective leadership of the with the awarding of a prestigious 6-year Senior Associate Dean for Research, National Cancer Institute Predoctoral to Melanie Cushion, PhD, and Senior Associate Postdoctoral Transition Award. Meanwhile Dean for Clinical Research, Brett Kissela, many of our students have continued MD. An aspirational goal of increasing our to garner numerous national level grant holdings by $25 million over the next fellowships from the National Institutes 5 years was suggested by the University. of Health, National Science Foundation, Attaining this goal will initiate many American Heart Association and several changes, including new faculty hires to others. All this recognition represents a enhance our discovery sciences and strong testament to the sustained quality facilitate translation of these discoveries and promise of the students recruited to improve health and clinical care; foster to our doctoral programs. We continue scientific curiosity and investigation for to emphasize student recruitment from students in our new undergraduate underrepresented or disadvantaged program; and create an environment backgrounds, and this year four of these of advanced clinical care that surpasses students were elected to the Yale Ciencia any in the region. • Academy, a national program funded by the NIH offering sustained exposure to professional development, personal growth and career-focused opportunities. IN THIS NEXT YEAR, our goals are to exceed the 2019 funding levels; provide new training opportunities for our research trainees under the direction of the Associate Dean for Graduate Education, Iain Cartwright, PhD and the Director of Medical Student Research Initiatives, Jason Blackard, PhD; continue to invigorate our research core infrastructure under the guidance of the Associate Dean for Research Core Facilities, Kenneth Greis, PhD; and sustain our upward trajectory RESEARCH ANNUAL REPORT 2019 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE 5 COLLEGE OF MEDICINE FY 2019 TOTAL NEW GRANT DOLLARS * $143 million AVERAGE FUNDING SUBMISSION SUCCESS RATE † 35% CLINICAL TRIAL REVENUE $14.5 million CLINICAL TRIALS PATIENT ENROLLMENT 2,657 EXTERNAL GRADUATE STUDENT FELLOWSHIP AWARDS 37 U.S. PATENT FILINGS * 61 * Increased from FY 2018 † Exceeded the national average RESEARCH ANNUAL REPORT 2019 UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE 6 FROM THE OFFICE OF THE DEAN / 3 RESEARCH FINDINGS / 8 WHAT’S NEXT / 36 RESEARCH HONORS / 50 STUDENT HIGHLIGHTS / 58 RESEARCH GRANTS / 66 COLLEGE OF MEDICINE PROFILE / 117 College of Medicine OFFICE OF RESEARCH Melanie T. Cushion, PhD Senior Associate Dean for Research Brett M. Kissela, MD, MS Senior Associate Dean for Clinical Research Ken D. Greis, PhD Associate Dean for Research Core Facilities Iain Cartwright, PhD Associate Dean for Graduate Education Jack Kues, PhD Associate Dean Continuous Professional Development Jason Blackard, PhD Director of Medical Student Research Initiatives Jen Veevers, PhD Scientific Writer Brieanne Sheehan Program Director 7 RESEARCH FINDINGS 8 RESEARCH FINDINGS Study Shows Technique to Be Effective in Identifying Smallest Lung Cancers RESEARCHERSRESEARCHERS at theat theUC UCCollege College of Medicine of haveMedicine found that have radiotracer found that local- radiotracer ization is a local simple- andization effective is a technique simple and identify effective and remove technique small to lung nodules in patients undergoing surgery. identify and remove small lung nodules in patients undergoing surgery. These results, reported in the Journal of Thoracic and Cardiovascular Surgery, provide evidence that this technique may be the best way to locate and remove suspi- cious spots that are detected on a CT scan, leading to better outcomes for patients. Radiotracer localization involves a radioactive material